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A 2015 study in the journal PLOS Biology estimated that $28 billion is spent annually in the U.S. on preclinical research that is not reproducible.

One reason for what some researchers have called a crisis in reproducibility is that in certain types of laboratories, some scientists still track their day-to-day research activities in paper notebooksor, worse yet, in their heads. Thats according to Scott Fulton, CEO of Madison, WI-based Cellara. The startup is developing software designed for researchers in stem cell labs that it says can improve reproducibility of experiments and collaboration among groups around the world.

Formed in 2012, Cellara has been working with several organizations in Wisconsin to develop and test its digital tools. The company plans to formally launch its CultureTrax software to the market later this month in Boston at the annual meeting of the International Society for Stem Cell Research.

Stem cells are undifferentiated cells that can be programmed to turn into specific cell types. Fulton says there are about 25,000 stem cell culture labs worldwide. Some of them have computerized systems for tracking cell cultures, he says, but many still use paper.

We interviewed more than 200 stem cell scientists over the last several years, he says. We found that [many] plan, track, and document all of their cell culture work using paper lab notebooks, just like Louis Pasteur did.

The name CultureTrax comes from culture track, which according to company materials refers to a combination of a cell line, container, and protocolthe predefined steps that make up a scientific experiment. Researchers who are growing stem cells can use Cellaras software to document the contents of containersand their individual compartmentsas well as what actions theyve taken within a given protocol. Users can also record observations and upload images to monitor whether cells are morphing or proliferating.

Many researchers who work with stem cells do so while standing or sitting in front of biosafety cabinets. Cellara provides customers with an iPad mount that can be attached to cabinets, so that users can more easily switch between logging information and hands-on work with the cells. The startups Web-based software is designed to run on both mobile devices and computers. Fulton says that stem cell scientists do the bulk of their documentation while sitting at their desks.

Multiple labs at both the Medical College of Wisconsin, which is located in the Milwaukee area, and the University of Wisconsin-Madison are currently using CultureTrax. Another recently signed customer is Kings College London, which has a stem cell and regenerative medicine department.

Alex Vodenlich, vice president of business development at Cellara, says the functions and ease of use of his companys software also makes it a useful tool for training aspiring stem cell technicians.

Cellara has formed a partnership with Madison Collegea nearby school that offers a variety of associate degree programs and certificates, including one in stem cell technologiesto train students using a version of the startups software. The program is supported in part by a $661,000 grant the National Science Foundation awarded the schoolin 2015.

Thats a whole other adjacent markettrying to educate the next generation of stem cell scientists, Vodenlich says.

Cellara has worked with Acumium, another software company based in Madison, to write the code for CultureTrax. Dan Costello, founder and CEO of Acumium, is one of Cellaras larger investors, Fulton says.

The startup has raised about $1.8 million in debt and equity funding to date, Fulton says. He says Cellara has spent about $1.5 million building CultureTrax, and is about 90 percent Next Page

Jeff Buchanan is the editor of Xconomy Wisconsin. Email: jbuchanan@xconomy.com

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