Poor patient-reported outcomes insurvivors of childhood hematologic malignancies are associated with thepresence of chronic health conditions, regardless of whether patients had receivedhematopoietic stem cell transplantation (HSCT) or conventional therapy,according to a study published in Blood.

Investigators compared symptomprevalence, health-related quality of life (HRQoL), and risk factors in adultsurvivors. In multivariate logistic regression analyses, these patient-reportedoutcomes were compared with results of surveys and medical assessments given tomembers of a noncancer control group (242 patients). Survivors of hematologicmalignancies were organized by treatment type to either HSCT group (112patients) or conventional treatment group (1106 patients).

Compared with individuals in the noncancer group, survivors who had received HSCT reported substantially higher rates of symptom prevalence across memory (adjusted odds ratio [aOR], 4.8), sensation (aOR, 4.7), pulmonary (aOR, 4.6), and motor/movement domains (aOR, 4.3). Physical HRQoL was also significantly worse for survivors who received HSCT, compared with patients who did not have cancer (aOR, 6.9).

The investigators found nosignificant difference between survivors from each treatment group in terms ofHRQoL and symptom prevalence by domain. Organ-specific chronic healthconditions were a greater indicator of the prevalence of most symptom domainsthan treatment type.

Some ocular symptoms showedhigher cumulative prevalence among those who received HSCT compared withconventional treatment. These related to eye dryness (P <.0001),difficulty seeing while aided by glasses (P <.0001), and doublevision (P =.04).

The goal of cancersurvivorship care is not merely to identify and manage medical complications,but also to improve daily functional status and HRQOL, the investigators wrote.

The researchers also indicatedthat clinicians should consider proactively screening survivors of pediatrichematologic malignancies, particularly those treated with HSCT who have chronichealth conditions, for symptoms phenotypes to aid in the early identificationof adverse events.

Reference

Yen HJ, Eissa H, Bhatt NS, et al. Patient-reported outcomes in survivors of childhood hematologic malignancies with hematopoietic stem cell transplant [published online April 2, 2020]. Blood. doi: 10.1182/blood.2019003858

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Chronic Health Conditions, Not Transplant Receipt, Linked to Symptom Prevalence in Survivors of Childhood Hematologic Malignancies - Hematology...