DUBLIN, April 15, 2021 /PRNewswire/ -- The "Global Induced Pluripotent Stem Cell (iPS Cell) Industry Report 2021" report has been added to ResearchAndMarkets.com's offering.

The main objectives of this report are to describe the current status of iPSC research, patents, funding events, industry partnerships, biomedical applications, technologies, and clinical trials for the development of iPSC-based therapeutics.

Since the discovery of induced pluripotent stem cells (iPSCs) a large and thriving research product market has grown into existence, largely because the cells are non-controversial and can be generated directly from adult cells. It is clear that iPSCs represent a lucrative market segment because methods for commercializing this cell type are expanding every year and clinical studies investigating iPSCs are swelling in number.

Therapeutic applications of iPSCs have surged in recent years. 2013 was a landmark year in Japan because it saw the first cellular therapy involving the transplant of iPSCs into humans initiated at the RIKEN Center in Kobe, Japan. Led by Masayo Takahashi of the RIKEN Center for Developmental Biology (CDB), it investigated the safety of iPSC-derived cell sheets in patients with macular degeneration.

In another world-first, Cynata Therapeutics received approval in 2016 to launch the world's first formal clinical trial of an allogeneic iPSC-derived cell product (CYP-001) for the treatment of GvHD.

Riding the momentum within the CAR-T field, Fate Therapeutics is developing FT819, its "off-the-shelf" iPSC-derived CAR-T cell product candidate. Numerous physician-led studies using iPSCs are also underway in Japan, a leading country for basic and applied iPSC applications.

iPS Cell Market Competitors

Today, FUJIFILM CDI has emerged as one of the largest commercial players within the iPSC sector. FUJIFILM CDI was founded in 2004 by Dr. James Thomson at the University of Wisconsin-Madison, who in 2007 derived iPSC lines from human somatic cells for the first time ever. The feat was accomplished simultaneously by Dr. Shinya Yamanaka's lab in Japan.

In 2009, ReproCELL, a company established as a venture company originating from the University of Tokyo and Kyoto University, made iPSC products commercially available for the first time with the launch of its human iPSC-derived cardiomyocytes, which it called ReproCario.

A European leader within the iPSC market is Ncardia, formed through the merger of Axiogenesis and Pluriomics. Founded in 2001, Axiogenesis initially focused on generating mouse embryonic stem cell-derived cells and assays, but after Yamanaka's iPSC technology became available, it became the first European company to license it in 2010. Ncardia's focus is on preclinical drug discovery and drug safety through the development of functional assays using human neuronal and cardiac cells.

In total, at least 68 distinct market competitors now offer various types of iPSC products, services, technologies and therapies.

iPS Cell Commercialization

Methods of commercializing induced pluripotent stem cells (iPSCs) are diverse and continue to expand. iPSC cell applications include, but are not limited to:

Since the discovery of iPSC technology in 2006, significant progress has been made in stem cell biology and regenerative medicine. New pathological mechanisms have been identified and explained, new drugs identified by iPSC screens are in the pipeline, and the first clinical trials employing human iPSC-derived cell types have been initiated.

Key Topics Covered:

1. REPORT OVERVIEW 1.1 Statement of the Report 1.2 Executive Summary

2. INTRODUCTION 2.1 Discovery of iPSCs 2.2 Barriers in iPSC Application 2.3 Timeline and Cost of iPSC Development 2.4 Current Status of iPSCs Industry 2.4.1 Share of iPSC-based Research within the Overall Stem Cell Industry 2.4.2 Major Focuses of iPSC Companies 2.4.3 Commercially Available iPSC-Derived Cell Types 2.4.4 Relative Use of iPSC-Derived Cell Types in Toxicology Testing Assays 2.4.5 Toxicology/Safety Testing Assays using iPSC-Derived Cell Types 2.5 Currently Available iPSC Technologies 2.6 Advantages and Limitations of iPSCs Technology

3. HISTORY OF INDUCED PLURIPOTENT STEM CELLS (IPSCS) 3.1 First iPSC generation from Mouse Fibroblasts, 2006 3.2 First Human iPSC Generation, 2007 3.3 Creation of CiRA, 2010 3.4 First High-Throughput screening using iPSCs, 2012 3.5 First iPSCs Clinical Trial Approved in Japan, 2013 3.6 The First iPSC-RPE Cell Sheet Transplantation for AMD, 2014 3.7 EBiSC Founded, 2014 3.8 First Clinical Trial using Allogeneic iPSCs for AMD, 2017 3.9 Clinical Trials for Parkinson's disease using Allogeneic iPSCs, 2018 3.10 Commercial iPSC Plant SMaRT Established, 2018 3.11 First iPSC Therapy Center in Japan, 2019

4. RESEARCH PUBLICATIONS ON iPSCS 4.1 Categories of Research Publications 4.2 Percent Share of Published Articles by Disease Type 4.3 Number of Articles by Country

5. IPSCS: PATENT LANDSCAPE 5.1 Timeline and Status of Patents 5.2 Patent Filing Destinations 5.2.1 Patent Applicant's Origin 5.2.2 Top Ten Global Patent Applicants 5.2.3 Collaborating Applicants of Patents 5.3 Patent Application Trends iPSC Preparation Technologies 5.4 Patent Application Trends in iPSC Differentiation Technologies 5.5 Patent Application Trends in Disease-Specific Cell Technologies

6. CLINICAL TRIALS INVOLVING iPSCS 6.1 Current Clinical Trials Landscape 6.1.1 Clinical Trials Involving iPSCs by Major Diseases 6.1.2 Clinical Trials Involving iPSCs by Country

7. FUNDING FOR iPSCs 7.1 Value of NIH Funding for iPSCs 7.1.1 NHI's Intended Funding Through its Component Organizations in 2020 7.1.2 NIH Funding for Select Universities for iPSC Studies 7.2 CIRM Funding for iPSCs

8. GENERATION OF INDUCED PLURIPOTENT STEM CELLS: AN OVERVIEW 8.1 Reprogramming Factors 8.2 Overview of Four Key Methods of Gene Delivery 8.3 Comparative Effectiveness of Different Vector Types 8.4 Genome Editing Technologies in iPSCs Generation

9. HUMAN iPSC BANKING 9.1 Cell Sources for iPSCs Banking 9.2 Reprogramming methods used in iPSC Banking 9.3 Workflow in iPSC Banks 9.4 Existing iPSC Banks

10. BIOMEDICAL APPLICATIONS OF iPSCS 10.1 iPSCs in Basic Research 10.2 iPSCs in Drug Discovery 10.3 iPSCs in Toxicology Studies 10.4 iPSCs in Disease Modeling 10.5 iPSCs within Cell-Based Therapies

11. OTHER NOVEL APPLICATIONS OF iPSCS 11.1 iPSCs in Tissue Engineering 11.2 iPSCs in Animal Conservation 11.3 iPSCs and Cultured Meat

12. DEAL-MAKING WITHIN THE iPSC SECTOR 12.1 License Agreement between FUJIFILM Cellular Dynamics and Sana 12.2 Century Therapeutics Closes $160 Million Series C Financing 12.3 Bluerock Gains Access to Ncardia's iPSCs-derived Cardiomyocytes 12.4 Fate Therapeutics' Deal with Janssen Biotech 12.5 Century Therapeutics Acquires Empirica Therapeutics 12.6 $250 Million Raised by Century Theraputics 12.7 BlueRock Therapeutics Launched with $225 Million 12.8 Collaboration between Allogene Therapeutics and Notch Therapeutics 12.9 Acquisition of Semma Therapeutics by Vertex Therapeutics 12.10 Evotec's Extended Collaboration with BMS 12.11 Licensing Agreement between Allele Biotechnology and Astellas 12.12 Codevelopment Agreement between Allele & SCM Lifesciences 12.13 Fate Therapeutics Signs $100 Million Deal with Janssen 12.14 Allele's Deal with Alpine Biotherapeutics 12.15 Editas and BlueRock's Development Agreement

13. MARKET OVERVIEW 13.1 Global Market for iPSCs by Geography 13.2 Global Market for iPSCs by Technology 13.3 Global Market for iPSCs by Biomedical Application 13.4 Global Market for iPSCs by Cell Types 3.5 Market Drivers 13.6 Market Restraints

14. COMPANY PROFILES

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Global Induced Pluripotent Stem Cell (iPS Cell) Market Report 2021: In Total, At Least 68 Distinct Market Competitors Now Offer Various Types of iPSC...