Starzl TE. The early days of transplantation. JAMA. 1994;272(21):1705.

Article CAS PubMed PubMed Central Google Scholar

Vanholder R, Dominguez-Gil B, Busic M, Cortez-Pinto H, Craig JC, Jager KJ, et al. Organ donation and transplantation: a multi-stakeholder call to action. Nat Rev Nephrol. 2021;17(8):55468.

Article PubMed PubMed Central Google Scholar

Aubert O, Yoo D, Zielinski D, Cozzi E, Cardillo M, Durr M, et al. COVID-19 pandemic and worldwide organ transplantation: a population-based study. Lancet Public Health. 2021;6(10):e709e19.

Article PubMed PubMed Central Google Scholar

Zhang Y, Klassen HJ, Tucker BA, Perez MT, Young MJ. CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism. J Neurosci. 2007;27(17):4499506.

Article CAS PubMed PubMed Central Google Scholar

Luo J, Baranov P, Patel S, Ouyang H, Quach J, Wu F, et al. Human retinal progenitor cell transplantation preserves vision. J Biol Chem. 2014;289(10):636271.

Article CAS PubMed PubMed Central Google Scholar

Han IC, Bohrer LR, Gibson-Corley KN, Wiley LA, Shrestha A, Harman BE, et al. Biocompatibility of Human Induced Pluripotent Stem cell-derived retinal progenitor cell grafts in immunocompromised rats. Cell Transpl. 2022;31:9636897221104451.

Article Google Scholar

Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, et al. Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS ONE. 2011;6(4):e18992.

Article CAS PubMed PubMed Central Google Scholar

Mandai M, Fujii M, Hashiguchi T, Sunagawa GA, Ito SI, Sun J, et al. iPSC-Derived retina transplants improve vision in rd1 end-stage retinal-degeneration mice. Stem Cell Reports. 2017;8(1):6983.

Article PubMed PubMed Central Google Scholar

Lin B, McLelland BT, Aramant RB, Thomas BB, Nistor G, Keirstead HS, et al. Retina organoid transplants develop photoreceptors and improve visual function in RCS rats with RPE dysfunction. Invest Ophthalmol Vis Sci. 2020;61(11):34.

Article CAS PubMed PubMed Central Google Scholar

McLelland BT, Lin B, Mathur A, Aramant RB, Thomas BB, Nistor G, et al. Transplanted hESC-Derived retina organoid sheets differentiate, integrate, and improve visual function in retinal degenerate rats. Invest Ophthalmol Vis Sci. 2018;59(6):2586603.

Article CAS PubMed PubMed Central Google Scholar

Zerti D, Hilgen G, Dorgau B, Collin J, Ader M, Armstrong L, et al. Transplanted pluripotent stem cell-derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration. Stem Cells. 2021;39(7):88296.

Article CAS PubMed Google Scholar

Santos-Ferreira T, Volkner M, Borsch O, Haas J, Cimalla P, Vasudevan P, et al. Stem cell-derived photoreceptor transplants differentially integrate into mouse models of cone-rod dystrophy. Invest Ophthalmol Vis Sci. 2016;57(7):350920.

Article CAS PubMed Google Scholar

Gagliardi G, Ben M, Barek K, Chaffiol A, Slembrouck-Brec A, Conart JB, Nanteau C, et al. Characterization and transplantation of CD73-Positive photoreceptors isolated from human iPSC-Derived retinal organoids. Stem Cell Reports. 2018;11(3):66580.

Article CAS PubMed PubMed Central Google Scholar

Chao JR, Lamba DA, Klesert TR, Torre A, Hoshino A, Taylor RJ, et al. Transplantation of human embryonic stem cell-derived retinal cells into the Subretinal Space of a non-human primate. Transl Vis Sci Technol. 2017;6(3):4.

Article PubMed PubMed Central Google Scholar

Zhu J, Cifuentes H, Reynolds J, Lamba DA. Immunosuppression via loss of IL2rgamma enhances long-term functional integration of hESC-Derived photoreceptors in the mouse retina. Cell Stem Cell. 2017;20(3):37484. e5.

Article CAS PubMed Google Scholar

Lamba DA, McUsic A, Hirata RK, Wang PR, Russell D, Reh TA. Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS ONE. 2010;5(1):e8763.

Article PubMed PubMed Central Google Scholar

Lamba DA, Gust J, Reh TA. Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in crx-deficient mice. Cell Stem Cell. 2009;4(1):739.

Article CAS PubMed PubMed Central Google Scholar

Lingam S, Liu Z, Yang B, Wong W, Parikh BH, Ong JY, et al. cGMP-grade human iPSC-derived retinal photoreceptor precursor cells rescue cone photoreceptor damage in non-human primates. Stem Cell Res Ther. 2021;12(1):464.

Article CAS PubMed PubMed Central Google Scholar

Aboualizadeh E, Phillips MJ, McGregor JE, DiLoreto DA Jr, Strazzeri JM, Dhakal KR, et al. Imaging transplanted photoreceptors in living Nonhuman Primates with single-cell resolution. Stem Cell Reports. 2020;15(2):48297.

Article CAS PubMed PubMed Central Google Scholar

Kruczek K, Gonzalez-Cordero A, Goh D, Naeem A, Jonikas M, Blackford SJI, et al. Differentiation and transplantation of embryonic stem cell-derived cone photoreceptors into a mouse model of end-stage retinal degeneration. Stem Cell Reports. 2017;8(6):165974.

Article CAS PubMed PubMed Central Google Scholar

Gonzalez-Cordero A, West EL, Pearson RA, Duran Y, Carvalho LS, Chu CJ, et al. Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina. Nat Biotechnol. 2013;31(8):7417.

Article CAS PubMed Google Scholar

Ballios BG, Cooke MJ, Donaldson L, Coles BL, Morshead CM, van der Kooy D, et al. A Hyaluronan-Based Injectable Hydrogel improves the survival and integration of stem cell progeny following transplantation. Stem Cell Reports. 2015;4(6):103145.

Article CAS PubMed PubMed Central Google Scholar

Klassen H, Sakaguchi DS, Young MJ. Stem cells and retinal repair. Prog Retin Eye Res. 2004;23(2):14981.

Article CAS PubMed Google Scholar

Eberle D, Santos-Ferreira T, Grahl S, Ader M. Subretinal transplantation of MACS purified photoreceptor precursor cells into the adult mouse retina.J Vis Exp. 2014(84):e50932.

Lakowski J, Gonzalez-Cordero A, West EL, Han YT, Welby E, Naeem A, et al. Transplantation of photoreceptor precursors isolated via a cell surface Biomarker Panel from embryonic stem cell-derived self-forming retina. Stem Cells. 2015;33(8):246982.

Article CAS PubMed Google Scholar

Semo M, Haamedi N, Stevanato L, Carter D, Brooke G, Young M, et al. Efficacy and safety of human retinal progenitor cells. Transl Vis Sci Technol. 2016;5(4):6.

Article PubMed PubMed Central Google Scholar

Aftab U, Jiang C, Tucker B, Kim JY, Klassen H, Miljan E, et al. Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res. 2009;89(3):30110.

Article CAS PubMed Google Scholar

Meyer JS, Shearer RL, Capowski EE, Wright LS, Wallace KA, McMillan EL, et al. Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2009;106(39):16698703.

Article CAS PubMed PubMed Central Google Scholar

Meyer JS, Howden SE, Wallace KA, Verhoeven AD, Wright LS, Capowski EE, et al. Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Stem Cells. 2011;29(8):120618.

Article CAS PubMed Google Scholar

Nakano T, Ando S, Takata N, Kawada M, Muguruma K, Sekiguchi K, et al. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell. 2012;10(6):77185.

Article CAS PubMed Google Scholar

Capowski EE, Samimi K, Mayerl SJ, Phillips MJ, Pinilla I, Howden SE, et al. Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines. Development. 2019. https://doi.org/10.1242/dev.171686.

Article PubMed PubMed Central Google Scholar

Phillips MJ, Perez ET, Martin JM, Reshel ST, Wallace KA, Capowski EE, et al. Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2. Stem Cells. 2014;32(6):148092.

Article CAS PubMed Google Scholar

Wiley LA, Burnight ER, DeLuca AP, Anfinson KR, Cranston CM, Kaalberg EE, et al. cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness. Sci Rep. 2016;6:30742.

Article CAS PubMed PubMed Central Google Scholar

Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, et al. From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium. Proc Natl Acad Sci U S A. 2014;111(23):851823.

Article CAS PubMed PubMed Central Google Scholar

Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Cao LH, et al. Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat Commun. 2014;5:4047.

Article CAS PubMed Google Scholar

Kuwahara A, Ozone C, Nakano T, Saito K, Eiraku M, Sasai Y. Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue. Nat Commun. 2015;6:6286.

Article CAS PubMed Google Scholar

Mellough CB, Collin J, Khazim M, White K, Sernagor E, Steel DH, et al. IGF-1 signaling plays an important role in the formation of Three-Dimensional laminated neural retina and other ocular structures from human embryonic stem cells. Stem Cells. 2015;33(8):241630.

Article PubMed Google Scholar

Singh RK, Mallela RK, Cornuet PK, Reifler AN, Chervenak AP, West MD, et al. Characterization of three-dimensional retinal tissue derived from human embryonic stem cells in adherent monolayer cultures. Stem Cells Dev. 2015;24(23):277895.

Article CAS PubMed PubMed Central Google Scholar

Lowe A, Harris R, Bhansali P, Cvekl A, Liu W. Intercellular adhesion-dependent cell survival and ROCK-Regulated actomyosin-driven forces mediate self-formation of a retinal organoid. Stem Cell Reports. 2016;6(5):74356.

Article CAS PubMed PubMed Central Google Scholar

Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro J, et al. Recapitulation of human Retinal Development from Human pluripotent stem cells generates transplantable populations of cone photoreceptors. Stem Cell Reports. 2017;9(3):82037.

Article PubMed PubMed Central Google Scholar

Wahlin KJ, Maruotti JA, Sripathi SR, Ball J, Angueyra JM, Kim C, et al. Photoreceptor outer segment-like structures in long-term 3D retinas from human pluripotent stem cells. Sci Rep. 2017;7(1):766.

Article PubMed PubMed Central Google Scholar

Ovando-Roche P, West EL, Branch MJ, Sampson RD, Fernando M, Munro P, et al. Use of bioreactors for culturing human retinal organoids improves photoreceptor yields. Stem Cell Res Ther. 2018;9(1):156.

Article CAS PubMed PubMed Central Google Scholar

Hallam D, Hilgen G, Dorgau B, Zhu L, Yu M, Bojic S, et al. Human-Induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient-dependent efficiency. Stem Cells. 2018;36(10):153551.

Article CAS PubMed Google Scholar

Luo Z, Zhong X, Li K, Xie B, Liu Y, Ye M, et al. An optimized system for effective derivation of three-dimensional retinal tissue via wnt signaling regulation. Stem Cells. 2018;36(11):170922.

Article CAS PubMed Google Scholar

NIH human embryonic stem cell registry. https://grants.nih.gov/stem_cells/registry/current.htm. Accessed 27 Feb 2023.

Guha P, Morgan JW, Mostoslavsky G, Rodrigues NP, Boyd AS. Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells. Cell Stem Cell. 2013;12(4):40712.

Article CAS PubMed Google Scholar

Singh VK, Kalsan M, Kumar N, Saini A, Chandra R. Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery. Front Cell Dev Biol. 2015;3:2.

Article PubMed PubMed Central Google Scholar

Mantripragada VP, Luangphakdy V, Hittle B, Powell K, Muschler GF. Automated in-process characterization and selection of cell-clones for quality and efficient cell manufacturing. Cytotechnology. 2020;72(5):61527.

Article CAS PubMed PubMed Central Google Scholar

Wiley LA, Anfinson KR, Cranston CM, Kaalberg EE, Collins MM, Mullins RF, et al. Generation of Xeno-Free, cGMP-compliant patient-specific iPSCs from skin biopsy. Curr Protoc Stem Cell Biol. 2017. https://doi.org/10.1002/cpsc.30.

Article PubMed PubMed Central Google Scholar

Bohrer LR, Wiley LA, Burnight ER, Cooke JA, Giacalone JC, Anfinson KR, et al. Correction of NR2E3 associated enhanced s-cone syndrome patient-specific iPSCs using CRISPR-Cas9. Genes (Basel). 2019. https://doi.org/10.3390/genes10040278.

Article PubMed PubMed Central Google Scholar

Hao Y, Hao S, Andersen-Nissen E, Mauck WM, Zheng S, Butler A, et al. Integrated analysis of multimodal single-cell data. Cell. 2021;184(13):3573-87e29.

Article CAS PubMed PubMed Central Google Scholar

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