Lpez-Otn, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: an expanding universe. Cell 186, 243278 (2023).
Article PubMed Google Scholar
Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell. Res. 25, 585621 (1961).
Article CAS PubMed Google Scholar
Harley, C. B., Vaziri, H., Counter, C. M. & Allsopp, R. C. The telomere hypothesis of cellular aging. Exp. Gerontol. 27, 375382 (1992).
Article CAS PubMed Google Scholar
Gorgoulis, V. et al. Cellular senescence: defining a path forward. Cell 179, 813827 (2019).
Article CAS PubMed Google Scholar
Copp, J. P., Desprez, P. Y., Krtolica, A. & Campisi, J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 5, 99118 (2010).
Article PubMed PubMed Central Google Scholar
Herdy, J. R. et al. Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimers disease. Cell Stem Cell 29, 16371652 (2022).
Article Google Scholar
Ng, P. Y., McNeely, T. L. & Baker, D. J. Untangling senescent and damage-associated microglia in the aging and diseased brain. FEBS J. 290, 13261339 (2023).
Article CAS PubMed Google Scholar
van Deursen, J. M. The role of senescent cells in ageing. Nature 509, 439446 (2014).
Article ADS PubMed PubMed Central Google Scholar
Crouch, J., Shvedova, M., Thanapaul, R., Botchkarev, V. & Roh, D. Epigenetic regulation of cellular senescence. Cells 11, 672 (2022).
Article CAS PubMed PubMed Central Google Scholar
Kowald, A., Passos, J. F. & Kirkwood, T. B. L. On the evolution of cellular senescence. Aging Cell 19, e13270 (2020).
Article CAS PubMed PubMed Central Google Scholar
Miwa, S., Kashyap, S., Chini, E. & von Zglinicki, T. Mitochondrial dysfunction in cell senescence and aging. J. Clin. Invest. 132, e158447 (2022).
Article CAS PubMed PubMed Central Google Scholar
Muoz-Espn, D. et al. Programmed cell senescence during mammalian embryonic development. Cell 155, 11041118 (2013).
Article PubMed Google Scholar
Gibaja, A. et al. TGF2-induced senescence during early inner ear development. Sci. Rep. 9, 5912 (2019).
Article ADS PubMed PubMed Central Google Scholar
Reichel, W., Hollander, J., Clark, J. H. & Strehler, B. L. Lipofuscin pigment accumulation as a function of age and distribution in rodent brain. J. Gerontol. 23, 7178 (1968).
Article CAS PubMed Google Scholar
Moreno-Garca, A., Kun, A., Calero, O., Medina, M. & Calero, M. An overview of the role of lipofuscin in age-related neurodegeneration. Front. Neurosci. 12, 464 (2018).
Article PubMed PubMed Central Google Scholar
Xu, P. et al. The landscape of human tissue and cell type specific expression and co-regulation of senescence genes. Mol. Neurodegener. 17, 5 (2022).
Article CAS PubMed PubMed Central Google Scholar
Saul, D. et al. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat. Commun. 13, 4827 (2022).
Article ADS CAS PubMed PubMed Central Google Scholar
Ogrodnik, M. et al. Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice. Aging Cell 20, e13296 (2021).
Article CAS PubMed PubMed Central Google Scholar
Bussian, T. J. et al. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature 562, 578582 (2018).
Article ADS CAS PubMed PubMed Central Google Scholar
Musi, N. et al. Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17, e12840 (2018).
Article PubMed PubMed Central Google Scholar
Rocha, L. R. et al. Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension. Aging Cell 19, e13089 (2020).
Article CAS PubMed Google Scholar
Zhang, P. et al. Senolytic therapy alleviates A-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimers disease model. Nat. Neurosci. 22, 719728 (2019).
Article CAS PubMed PubMed Central Google Scholar
Chinta, S. J. et al. Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinsons disease. Cell Rep. 22, 930940 (2018).
Article CAS PubMed PubMed Central Google Scholar
Gonzales, M. M. et al. Senolytic therapy to modulate the progression of Alzheimers disease (SToMP-AD): a pilot clinical trial. J. Prev. Alzheimers Dis. 9, 2229 (2022).
CAS PubMed Google Scholar
Dehkordi, S. K. et al. Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology. Nat. Aging 1, 11071116 (2021).
Article PubMed PubMed Central Google Scholar
Langfelder, P. & Horvath, S. Eigengene networks for studying the relationships between co-expression modules. BMC Syst. Biol. 1, 54 (2007).
Article PubMed PubMed Central Google Scholar
Geng, Y. Q., Guan, J. T., Xu, X. H. & Fu, Y. C. Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons. Biochem. Biophys. Res. Commun. 396, 866869 (2010).
Article CAS PubMed Google Scholar
Bhanu, M. U., Mandraju, R. K., Bhaskar, C. & Kondapi, A. K. Cultured cerebellar granule neurons as an in vitro aging model: topoisomerase II as an additional biomarker in DNA repair and aging. Toxicol. In Vitro 24, 19351945 (2010).
Article PubMed Google Scholar
de Mera-Rodrguez, J. A. et al. Endogenous pH 6.0 -galactosidase activity is linked to neuronal differentiation in the olfactory epithelium. Cells 11, 298 (2022).
Article PubMed PubMed Central Google Scholar
Piechota, M. et al. Is senescence-associated -galactosidase a marker of neuronal senescence? Oncotarget 7, 8109981109 (2016).
Article PubMed PubMed Central Google Scholar
Jurk, D. et al. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 11, 9961004 (2012).
Article CAS PubMed Google Scholar
Moreno-Blas, D. et al. Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy. Aging 11, 61756198 (2019).
Article CAS PubMed PubMed Central Google Scholar
Bigagli, E. et al. Long-term neuroglial cocultures as a brain aging model: hallmarks of senescence, microRNA expression profiles, and comparison with in vivo models. J. Gerontol. A Biol. Sci. Med. Sci. 71, 5060 (2016).
Article CAS PubMed Google Scholar
Kang, H. T., Lee, K. B., Kim, S. Y., Choi, H. R. & Park, S. C. Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS ONE 6, e23367 (2011).
Article ADS CAS PubMed PubMed Central Google Scholar
Wong, A., Kieu, T. & Robbins, P. D. The Ercc1/ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions. Aging 12, 2448124483 (2020).
Article CAS PubMed PubMed Central Google Scholar
Yousefzadeh, M. J. et al. Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. Aging Cell 19, e13094 (2020).
Article CAS PubMed PubMed Central Google Scholar
de Waard, M. C. et al. Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice. Acta Neuropathol. 120, 461475 (2010).
Article CAS PubMed PubMed Central Google Scholar
Doll, M. E. et al. Broad segmental progeroid changes in short-lived Ercc1/7 mice. Pathobiol. Aging Age Relat. Dis. 1, 10.3402/pba.v1i0.7219(2011).
Sepe, S. et al. Inefficient DNA repair Is an aging-related modifier of Parkinsons disease. Cell Rep. 15, 18661875 (2016).
Article CAS PubMed PubMed Central Google Scholar
Pachajoa, H. et al. HutchinsonGilford progeria syndrome: clinical and molecular characterization. Appl. Clin. Genet. 13, 159164 (2020).
Article CAS PubMed PubMed Central Google Scholar
Machiela, E. et al. The interaction of aging and cellular stress contributes to pathogenesis in mouse and human huntington disease neurons. Front Aging Neurosci. 12, 524369 (2020).
Article CAS PubMed PubMed Central Google Scholar
Baek, J. H. et al. Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior. Hum. Mol. Genet. 24, 13051321 (2015).
Article CAS PubMed Google Scholar
Arendt, T., Rdel, L., Grtner, U. & Holzer, M. Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimers disease. Neuroreport 7, 30473049 (1996).
Article CAS PubMed Google Scholar
McShea, A., Harris, P. L., Webster, K. R., Wahl, A. F. & Smith, M. A. Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimers disease. Am. J. Pathol. 150, 19331939 (1997).
CAS PubMed PubMed Central Google Scholar
Wang, B. et al. An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Nat. Aging 1, 962973 (2021).
Article PubMed PubMed Central Google Scholar
Hu, W. et al. Direct conversion of normal and Alzheimers disease human fibroblasts into neuronal cells by small molecules. Cell Stem Cell 17, 204212 (2015).
Article CAS PubMed Google Scholar
Mertens, J. et al. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell 17, 705718 (2015).
Article CAS PubMed PubMed Central Google Scholar
Yoo, A. S. et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 476, 228231 (2011).
Article ADS CAS PubMed PubMed Central Google Scholar
Capano, L. S. et al. Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons. Cell Stem Cell 29, 918932 (2022).
Article CAS PubMed PubMed Central Google Scholar
Zhang, C. et al. Establishing RNAge to score cellular aging and rejuvenation paradigms and identify novel age-modulating compounds. Preprint at bioRxiv https://doi.org/10.1101/2023.07.03.547539 (2023).
Sun, Z. et al. Endogenous recapitulation of Alzheimers disease neuropathology through human 3D direct neuronal reprogramming. Preprint at bioRxiv https://doi.org/10.1101/2023.05.24.542155 (2023).
Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 11451147 (1998).
See original here:
Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration - Nature.com
- 10. The Promise of Induced Pluripotent Stem Cells (iPSCs ... [Last Updated On: May 5th, 2015] [Originally Added On: May 5th, 2015]
- What are induced pluripotent stem cells? [Stem Cell ... [Last Updated On: May 5th, 2015] [Originally Added On: May 5th, 2015]
- Embryonic and induced pluripotent stem cells Part 6 - Video [Last Updated On: May 5th, 2015] [Originally Added On: May 5th, 2015]
- Embryonic and induced pluripotent stem cells Part 2 - Video [Last Updated On: May 5th, 2015] [Originally Added On: May 5th, 2015]
- Embryonic and induced pluripotent stem cells Part 5 - Video [Last Updated On: May 5th, 2015] [Originally Added On: May 5th, 2015]
- Embryonic and induced pluripotent stem cells Part 3 - Video [Last Updated On: May 5th, 2015] [Originally Added On: May 5th, 2015]
- Embryonic and induced pluripotent stem cells Part 4 - Video [Last Updated On: May 5th, 2015] [Originally Added On: May 5th, 2015]
- Embryonic and induced pluripotent stem cells Part 1 - Video [Last Updated On: May 5th, 2015] [Originally Added On: May 5th, 2015]
- piggyBac transposition reprograms fibroblasts to induced ... [Last Updated On: May 8th, 2015] [Originally Added On: May 8th, 2015]
- Induced Pluripotent Stem Cells (IPSCs) - HowStuffWorks [Last Updated On: May 27th, 2015] [Originally Added On: May 27th, 2015]
- Pluripotency of Induced Pluripotent Stem Cells [Last Updated On: May 27th, 2015] [Originally Added On: May 27th, 2015]
- Induced stem cells - Wikipedia, the free encyclopedia [Last Updated On: May 27th, 2015] [Originally Added On: May 27th, 2015]
- Induced Pluripotent Stem Cells (iPS) | UCLA Broad Stem ... [Last Updated On: May 27th, 2015] [Originally Added On: May 27th, 2015]
- iPS cells and reprogramming: turn any cell of the body ... [Last Updated On: June 2nd, 2015] [Originally Added On: June 2nd, 2015]
- induced pluripotent stem cells - RCN Corporation [Last Updated On: July 3rd, 2015] [Originally Added On: July 3rd, 2015]
- Generating Mice from Induced Pluripotent Stem Cells | Protocol [Last Updated On: July 3rd, 2015] [Originally Added On: July 3rd, 2015]
- Stem Cell Key Terms | California's Stem Cell Agency [Last Updated On: July 31st, 2015] [Originally Added On: July 31st, 2015]
- Cell potency - Wikipedia, the free encyclopedia [Last Updated On: July 31st, 2015] [Originally Added On: July 31st, 2015]
- Induced pluripotent stem cell therapy - Wikipedia, the ... [Last Updated On: August 3rd, 2015] [Originally Added On: August 3rd, 2015]
- Glossary [Stem Cell Information] [Last Updated On: August 15th, 2015] [Originally Added On: August 15th, 2015]
- STEMCELL Technologies Inc. Enters a Licensing Agreement ... [Last Updated On: August 29th, 2015] [Originally Added On: August 29th, 2015]
- Pluripotent Stem Cells 101 | Boston Children's Hospital [Last Updated On: September 10th, 2015] [Originally Added On: September 10th, 2015]
- COMPLETE 2015-16 INDUCED PLURIPOTENT STEM CELL INDUSTRY REPORT [Last Updated On: October 20th, 2015] [Originally Added On: October 20th, 2015]
- Complete 2015-16 Induced Pluripotent Stem Cell Industry ... [Last Updated On: October 20th, 2015] [Originally Added On: October 20th, 2015]
- Derivation of Ethnically Diverse Human Induced Pluripotent ... [Last Updated On: October 21st, 2015] [Originally Added On: October 21st, 2015]
- Purest yet liver-like cells generated from induced ... [Last Updated On: August 30th, 2016] [Originally Added On: August 30th, 2016]
- World Induced Pluripotent Stem Cells Market - Opportunities ... [Last Updated On: September 18th, 2016] [Originally Added On: September 18th, 2016]
- Induced Pluripotent Stem Cells Market 2016: Hepatocytes ... [Last Updated On: September 18th, 2016] [Originally Added On: September 18th, 2016]
- The Promise of Induced Pluripotent Stem Cells (iPSCs ... [Last Updated On: September 23rd, 2016] [Originally Added On: September 23rd, 2016]
- Induced Pluripotent Stem Cells: 10 Years After the ... [Last Updated On: September 28th, 2016] [Originally Added On: September 28th, 2016]
- Induced Pluripotent Stem Cell Initiative | California's ... [Last Updated On: October 7th, 2016] [Originally Added On: October 7th, 2016]
- Stem Cell Basics VI. | stemcells.nih.gov [Last Updated On: October 12th, 2016] [Originally Added On: October 12th, 2016]
- Induced stem cells - Wikipedia [Last Updated On: October 18th, 2016] [Originally Added On: October 18th, 2016]
- Induced Pluripotent Stem Cells (iPS) - UCLA Broad Stem Cell [Last Updated On: October 21st, 2016] [Originally Added On: October 21st, 2016]
- Induced Pluripotent Stem Cells: A New Frontier for Stem ... [Last Updated On: October 27th, 2016] [Originally Added On: October 27th, 2016]
- Induced pluripotent stem cells and Parkinson's disease ... [Last Updated On: October 27th, 2016] [Originally Added On: October 27th, 2016]
- Generation of Induced Pluripotent Stem Cells with ... [Last Updated On: November 3rd, 2016] [Originally Added On: November 3rd, 2016]
- Generation of Neural Crest-Like Cells From Human ... [Last Updated On: November 14th, 2016] [Originally Added On: November 14th, 2016]
- Induced pluripotent stem-cell therapy - Wikipedia [Last Updated On: November 18th, 2016] [Originally Added On: November 18th, 2016]
- Generation of germline-competent induced pluripotent stem ... [Last Updated On: November 22nd, 2016] [Originally Added On: November 22nd, 2016]
- Induced pluripotent stem cell models from X-linked ... [Last Updated On: November 23rd, 2016] [Originally Added On: November 23rd, 2016]
- Live Cell Imaging of Induced Pluripotent Stem Cell ... [Last Updated On: November 23rd, 2016] [Originally Added On: November 23rd, 2016]
- Induced Pluripotent Stem Cells - cellapplications.com [Last Updated On: November 23rd, 2016] [Originally Added On: November 23rd, 2016]
- Why Induced Pluripotent Stem Cells Are Vital for Glaucoma ... [Last Updated On: December 3rd, 2016] [Originally Added On: December 3rd, 2016]
- Stem Cell Glossary - stemcells.nih.gov [Last Updated On: December 5th, 2016] [Originally Added On: December 5th, 2016]
- Clinical potential of human-induced pluripotent stem cells ... [Last Updated On: December 5th, 2016] [Originally Added On: December 5th, 2016]
- Induced stem cells - Wikiversity [Last Updated On: December 17th, 2016] [Originally Added On: December 17th, 2016]
- Induced pluripotent stem cell Wikipedia StemCell Therapy [Last Updated On: December 17th, 2016] [Originally Added On: December 17th, 2016]
- Embryonic stem (ES) cells and induced pluripotent stem ... [Last Updated On: January 17th, 2017] [Originally Added On: January 17th, 2017]
- Induced Pluripotent Stem Cell Repository | California's ... [Last Updated On: January 23rd, 2017] [Originally Added On: January 23rd, 2017]
- induced pluripotent stem cells - eurostemcell.org [Last Updated On: January 27th, 2017] [Originally Added On: January 27th, 2017]
- When C9ORF72 Silences U2, Spliceosomes Can't Find What They ... - Alzforum [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- The Stem Cell Revolution - Seeking Alpha [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- Evotec in neurology iPSC drug discovery collaboration with stem-cell specialist Censo - FierceBiotech [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- Treating Asthma with Stem Cells | Technology Networks - Technology Networks [Last Updated On: July 1st, 2017] [Originally Added On: July 1st, 2017]
- Embryonic stem cells to be available for medical use in Japan by next March - The Japan Times [Last Updated On: July 5th, 2017] [Originally Added On: July 5th, 2017]
- This Study Could Help Extend the Human Lifespan - Futurism [Last Updated On: July 8th, 2017] [Originally Added On: July 8th, 2017]
- Grnenthal Group: Launch of the Project - Modelling Neuron-glia Networks Into a Drug Discovery Platform for Pain ... - PR Newswire (press release) [Last Updated On: July 8th, 2017] [Originally Added On: July 8th, 2017]
- The Global Market for Induced Pluripotent Stem Cells (iPSCs) should reach $3.6 Billion in 2021, Increasing at a CAGR ... - Business Wire (press... [Last Updated On: July 8th, 2017] [Originally Added On: July 8th, 2017]
- SBP Scientist Receives Prestigious WM Keck Foundation Grant - Newswise (press release) [Last Updated On: July 11th, 2017] [Originally Added On: July 11th, 2017]
- Is it time to start worrying about conscious human mini-brains? - PLoS Blogs (blog) [Last Updated On: August 2nd, 2017] [Originally Added On: August 2nd, 2017]
- A New Epigenetic Barrier to Induced Pluripotent Stem Cells - WhatIsEpigenetics.com [Last Updated On: August 2nd, 2017] [Originally Added On: August 2nd, 2017]
- What are induced pluripotent stem cells or iPS cells? - Stem ... [Last Updated On: August 2nd, 2017] [Originally Added On: August 2nd, 2017]
- Stem Cell Glossary - Closer Look at Stem Cells [Last Updated On: August 2nd, 2017] [Originally Added On: August 2nd, 2017]
- CRISPR Corrects Disease Mutation in Human Embryos - Genetic Engineering & Biotechnology News (blog) [Last Updated On: August 3rd, 2017] [Originally Added On: August 3rd, 2017]
- World's 1st trial of drug developed from iPS cells to begin - Japan ... - Japan Today [Last Updated On: August 3rd, 2017] [Originally Added On: August 3rd, 2017]
- ASU grad students' lab skills help earn funding for cutting-edge biomedical research - Arizona State University [Last Updated On: August 10th, 2017] [Originally Added On: August 10th, 2017]
- How Food Preservatives May Disrupt Human Hormones - Laboratory Equipment [Last Updated On: August 10th, 2017] [Originally Added On: August 10th, 2017]
- Dopaminergic neurons derived from iPSCs in non-human primate model - Phys.Org [Last Updated On: August 12th, 2017] [Originally Added On: August 12th, 2017]
- Artificial Blood Vessels Mimic Rare Accelerated Aging Disease - Duke Today [Last Updated On: August 15th, 2017] [Originally Added On: August 15th, 2017]
- Induced Pluripotent Stem Cells Market Demands, Trends, Growth ... - MilTech [Last Updated On: August 15th, 2017] [Originally Added On: August 15th, 2017]
- induced pluripotent stem cell (iPS cell) | biology ... [Last Updated On: August 15th, 2017] [Originally Added On: August 15th, 2017]
- Induced Pluripotent Stem Cells: Global Markets Report 2017-2021 [Last Updated On: August 15th, 2017] [Originally Added On: August 15th, 2017]
- MESO-BRAIN initiative receives 3.3million to replicate brain's neural networks through 3D nanoprinting - Cordis News [Last Updated On: August 15th, 2017] [Originally Added On: August 15th, 2017]
- Global Induced Pluripotent Stem Cells Market: HTF Market [Last Updated On: August 15th, 2017] [Originally Added On: August 15th, 2017]
- Induced Pluripotent Stem Cells in Global Effort to ... [Last Updated On: August 15th, 2017] [Originally Added On: August 15th, 2017]
- How Do We Get Pluripotent Stem Cells? | Boston Children's ... [Last Updated On: August 15th, 2017] [Originally Added On: August 15th, 2017]
- Fertile offspring produced from sterile mice using iPS cells - Kyodo News Plus [Last Updated On: August 20th, 2017] [Originally Added On: August 20th, 2017]
- Brain Spheroids Hatch Mature Astrocytes | ALZFORUM - Alzforum [Last Updated On: August 20th, 2017] [Originally Added On: August 20th, 2017]
- Breakthrough in Gene Editing Comes as Scientists Correct Disease-Causing Mutation in Human Embryo - TrendinTech [Last Updated On: August 20th, 2017] [Originally Added On: August 20th, 2017]