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The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut – EurekAlert

image:

Figure 6.Inhibitory effect of VitD on age- and oxidative stress-related accumulation of supernumerary centrosomes in midgut ISCs.

Credit: 2024 Park et al.

Our study demonstrated that the VitD/VDR [vitamin D/vitamin D receptor] pathway is required for intestinal homeostasis during normal differentiation and aging.

BUFFALO, NY- February 27, 2024 A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut.

Adult stem cells are pivotal for maintaining tissue homeostasis, and their functional decline is linked to aging and its associated diseases, influenced by the niche cells environment. Age- and cancer-related reduction of vitamin D and its receptor levels are well documented in human clinical studies. However, the mechanisms through which the vitamin D/vitamin D receptor (VitD/VDR) pathway contributes to anti-aging and extends life expectancy are not well understood. In this new study, researchers Joung-Sun Park, Hyun-Jin Na and Yung-Jin Kim from Pusan National University and Korea Food Research Institute aimed to determine the protective role of the vitamin D/vitamin D receptor pathway in differentiated enterocytes (ECs) during intestinal stem cell (ISC) aging.

This study aimed to determine the protective role of VitD/VDR in differentiated ECs during ISC aging using the adult Drosophila intestine model.

By utilizing a well-established Drosophila midgut model for stem cell aging biology, the researchers revealed that vitamin D receptor knockdown in ECs induced ISC proliferation, EC death, ISC aging, and enteroendocrine cell differentiation. Additionally, age- and oxidative stress-induced increases in ISC proliferation and centrosome amplification were reduced by vitamin D treatment. In conclusion, this study provides direct evidence of the anti-aging role of the VitD/VDR pathway, involving protecting ECs during aging, and provides valuable insights for exploring the molecular mechanisms underlying enhanced healthy aging in Drosophila.

Our findings suggest a direct evidence of the anti-aging role of the vitamin D/vitamin D receptor pathway and provides insights into the molecular mechanisms underlying healthy aging in Drosophila.

Read the full paper: DOI: https://doi.org/10.18632/aging.205518

Corresponding Author: Joung-Sun Park

Corresponding Email: dreamjs78@pusan.ac.kr

Keywords: Drosophila, vitamin D, vitamin D receptor, anti-aging, intestinal stem cell

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About Aging:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancerand now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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Observational study

Animals

The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut

7-Feb-2024

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut - EurekAlert

Dr. Tsambarlis on platelet-rich plasma and shock wave therapy for erectile dysfunction – Urology Times

In this video, Peter N. Tsambarlis, MD, discusses regenerative therapies for erectile dysfunction. Tsambarlis is a urologist with Northwestern Medicine in Chicago, Illinois.

The 2 main regenerative therapies are platelet-rich plasma [PRP] and shock wave therapy. But regenerative therapies is a much bigger group than that; it includes things like stem cell therapy, there are some studies with amniotics, but the 2 that are getting the most energy and the most momentum are PRP and shock wave therapy.

These are extremely popular. Obviously, we practice in Chicago, which is a really big city, and you have a subset of people who do a ton of research, by the looser definition, certainly, and want to know more about these therapies. They usually come in with a specific goal, in my experience. "I want to know about shock wave." "I want to know about PRP and if it's good for me." I try to cater the response to who it is. For example, I don't think there's anyone for whom we have good data that PRP is efficacious. But we know it's safe. But those are 2 important but very different things. Just because something is safe doesn't mean it's the best treatment option. There are just no good data that say that this is going to work for erectile dysfunction. I think that's what we want to focus on here. But certainly, there are wonderful data for PRP in the orthopedic literature. But we're not seeing it in erectile dysfunction, and even less so in things like Peyronie disease, which fall under the sexual health umbrella, but in reality are not what people are coming in for on a regular basis in my clinic. Now, the shock wave, on the other hand is really different. Shock wave has some emerging data that are getting stronger and stronger. It may not be a perfect therapy right now for everybody. And as we start to cater, who are the best candidates? What are the appropriate settings? What are the best machines? We're finding out that there are a subset of ED patients who are benefiting from shock wave, and it is more of a call to research. How do we identify the proper protocol? How do we optimize patient selection to get these things to work? But since we don't exactly know, I don't think it's wrong to offer it in patients for whom you have a reasonable expectation of success, but you have to be really transparent about it. You can't promise the world if you don't have the world to give.

PRP is not ready to be utilized as a treatment. It can be utilized as an experimental, but do it in the setting of an experiment, of a trial, something that's controlled. Shock wave is way further down the road, in my opinion. I think it's a reasonable option, as long as you're transparent about it. But you still have to make sure as a patient that you're getting that therapy from somewhere that has, for example, focal shock waves. A lot of these outside clinics are using radial waves, and we have excellent trade of them that is not useful. Not all shock wave is created equal, and it underscores the importance of going somewhere that you can trust. I think even if this is offered as a therapy, which maybe is associated with some sort of reimbursement, it needs to be somewhere where the data can be tracked. I think there's kind of a gray area - are we at the point where this is ready for primetime and this can be offered? "I'm not sure," is the answer. But there are enough encouraging data that say it is definitely safe and might be efficacious, that I think at least if we're tracking the data, we can provide benefit to some people and then utilize what we learn to help a larger portion.

This transcription was edited for clarity.

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Dr. Tsambarlis on platelet-rich plasma and shock wave therapy for erectile dysfunction - Urology Times

U.S. Senators Introduce Bill to Protect Aborted Babies from Medical Experimentation – Daily Citizen

In late January, pro-life senators introduced legislation to protect the human remains of aborted babies from medical experimentation for research purposes.

The bill,S. 3713, is titledProtecting Life and Integrity in Research Act of 2024.

If passed, the measure would prohibit the federal government from funding, approving, or in any way supporting research on aborted babies.

The language of S. 3713 expressly forbids medical research organization to solicit or accept aborted fetal human remains as a research donation.

Senator Cindy Hyde-Smith, chair of theSenate Pro-Life Caucus, is the bills primary sponsor. Seventeen other senators join her ascosponsors.

The law regulating human fetal tissue research is complex. Over the years, federal policy has changed significantly based on the views of each presidential administration.

Currentfederal lawpermits research on fetal human tissue if human embryos are not intentionally created or destroyed for the explicit purpose of research.

According to those statutory stipulations, it is still lawful for taxpayer dollars to fund research on aborted babies if the aborting mothers consent.

Opponents of this practice contend that taxpayers money should not be used to promote unethical research on children.

In apress release, Senator Hyde-Smith called the harvesting and trafficking of aborted babies body parts heinous and unethical.

Proponents tout the possibility of discovering medical advancements by using human fetal tissue, but recentanalysisby the Charlotte Lozier Institute calls that assumption into question.

The reportconcludesthat medical research using ethically non-controversial adult and induced pluripotent stem cells continues to advance in the pursuit of cures and treatments, while embryonic stem cells have largely fallen by the wayside, proving that science does not need to kill in order to cure.

Since 2015, the National Institutes of Healths funding for human fetal tissue research has been as high as $115 million annually. Spending for 2024 isprojectedto be approximately $61 million.

Source: National Institutes of Health

Focus on the Family, asreportedby the Daily Citizen, believes human fetal tissue research requiring the destruction of human beings is a violation of the sanctity of life.

Every human, in every condition from the single cell stage of development to natural death, is made in Gods image and possesses inestimable worth. Our human nature not our size, level of development, environment or functional capacity gives us worth and dignity as human beings. Therefore, devaluing and destroying the life of a human embryo opens the door to the devaluing and destroying any human life.

According to supporters of the legislation, the bill is endorsed by Susan B. Anthony Pro-Life America, Americans United for Life, Catholic Vote, March for Life Action, U.S. Conference of Catholic Bishops Committee on Pro-Life Activities, Students for Life Action, and Concerned Women for America LAC.

A companion measure was introduced in the U.S. House of Representatives last year,H.R. 398, but no action has been taken to advance the legislation.

The Senate bill was referred to the Senate Committee on Health, Education, Labor, and Pensions, where it awaits further action. The Daily Citizen will keep you updated on its progress.

Image from Shutterstock.

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U.S. Senators Introduce Bill to Protect Aborted Babies from Medical Experimentation - Daily Citizen

Stem-Cell Penis Enlargement: Biohackers Increasing the Size of Their Penis – Men’s Health UK

'You might feel a bee sting' was the warning neurosurgeon Marcella Madera gave Shawn Wells as she made the first of six injections deep into the base of his penis.

The biochemist and entrepreneur soon began to breathe heavily from the extreme discomfort, while Madera continued pumping embryonic stem cells extracted from his legs into his manhood. Is it pain or pressure? Madera asked. Both, was the gritted-teeth response from Wells, who had come to the Restorative Medicine Center in Austin, Texas, for the Adonis Experience, a suite of cutting edge, experimental rejuvenation treatments for men that promise penis enhancement and sexual optimisation.

The desire to enhance the look and feel of ones penis

More recently, doctors have been injecting fat so-called penile fillers from patients stomachs into their penises. There have been apparent successes, but many have been left with wonky, deformed cocks rather than the handsome truncheons they craved. Penile implants and lengthening surgeries, equally, have left some men fulfilled and proud, and others flabbergasted and dismayed. In Sweden, in 2017, a 30-year-old man had a heart attack and died just after having fat cells injected into his penis.

But cutting-edge technological advancements are changing whats possible. Stem-cell injections and shock therapy are becoming the means du jour for men seeking to become more content with their penises, and increasing numbers of men claim they help reverse the inevitable effects of ageing while also improving performance.

It's no wonder people are so excited about it all. Half of all men above 40 are affected by erectile dysfunction, or impotence, and as testosterone levels decline, erections lose strength and orgasms become less intense. Im approaching 50; it's important for it to work just as well as it ever has done, says Wells.

Shawn Wells with Dr Marcella Madera.

A year-and-a-half after his own procedure, Wells says his erections are back to full strength, after having softened with age. Sometimes he hadnt even been able to get an erection or would lose it halfway through sex. That's no longer the case. I gained as much as 20% (in length and strength). It literally looks and feels bigger. Enjoyment levels have increased too. When it's more erect, not only are you giving her more pleasure, youre getting more pleasure too, because the more blood flow there is, the more sensation. And certainly, it lasts longer.

According to Wells account, it appears that he has reversed the symptoms of erectile dysfunction that creep up on men as they grey. He has decreased his penile age, after finally getting stem-cell injections in his dick following almost a decade getting them elsewhere in his body to biohack his biological clock back to age 33. After all, what kind of longevity regimen doesn't also make you 'last longer'?

But Wells isnt the only biohacker taking on penile ageing. Bryan Johnson, the tech entrepreneur and poster boy of the longevity movement, uses a wand-like instrument to shock his penis through acoustic technology in an attempt to reverse his aging dick and get the erections of an 18-year-old.

On a Zoom call at the end of January, Johnson told Mens Health that just the week before he had received Botox injections in his penis after reading that it could be beneficial. It increased blood flow, he says. It increased penile length [and gave me] stronger erections.

Johnson, who says he already had ideal penis health when he embarked on this journey, has previously been lampooned by some for sharing how he straps a small sensor device to his penis several nights a month to measure the strength of his erections and ensure his penile age is decreasing. But night time erections are really important indicators of sexual, physiological and cardiovascular health, he says. When I shared this publicly, several of my friends messaged me to say they think they have none. Theyre all signed up with grind culture, Johnson says, and not prioritising sleep, and therefore their cocks arent working properly.

At his last erection-strength reading, the 46-year-old, who famously spends $2m a year to ward off ageing through various means, was erect for about two hours, 12 minutes on average per night, giving him a penile age of just over 30. To reach the level of a late-teen, he would have to be hard for three-and-a-half hours during sleep.

Unfortunately, the contraption Johnson has been using got a bug preventing fresh data capture over the past two months. A new device is on its way, but for him, the jury has already given its verdict. I perform better sexually than I have in my entire life, he says. In terms of penile health, readiness, and desire. Im probably at peak ability.

Johnson believes the unpleasant extracorporeal sound-wave shocks (in pain terms a 7/10 on the shaft, but 9/10 at the tip, he says) that are said to strengthen the pelvic floor where some of the muscles attached to the base of the penis originate were therefore worth it.

But whats the deeper reason behind the drive to de-age the dick? Johnson and Wells have a history of obesity and depression in common and today theyre hungry to make up for time spent not living their current baller lifestyles and to achieve eternal youth. It took me years to remove that internal demon, Johnson has said. I spent most of my life with PTSD, feeling suicidal, and depressed, says Wells.

Both Wells and Johnson spoke at the longevity and psychedelics conference Wonderland, held by the company Microdose, in Miami, at the end of last year. Another of the attendees, Dave Asprey, author and self-proclaimed father of biohacking, gave a talk on the secrets of brain longevity and declared that he intended to live until at least 180. Id like to have a really active sex life as part of that, he says to Men's Health.

Asprey first received stem-cell injections in his penis in 2015, and has since done the treatment several further times. He also has a shockwave machine at home. Doing those and shockwaves three times, I grew about an inch and a half, he reveals.

Asprey says it was not his goal to change the size of his penis, it was more that he routinely tests new biohacking technologies, but he believes he was the first person to talk publicly about biohacking his penis. It's tough to talk about because bragging about your dick size is the douchiest thing you could do So youd have to ask my girlfriend, thats the kind of results you get from it.

Dave Asprey, the so-called father of biohacking, uses a shockwave machine at home. He says it's enabled him to grow about an inch and a half.

The 50-year-old is content with his role spearheading the wave of penile health consciousness, though he is yet to wear the FirmTech ring at night to measure his erectile health and fitness. But Asprey claims that thousands of men have followed his lead and undergone restorative therapies for erectile dysfunction. I would guess that as a result of my podcast, at least 50,000 guys have gone out and done this, he says. I remember one time I told a group of friends at dinner, guys in their 40s to 60s. All of them went out and got it done. A couple of them came back and were like, Damn, yeah, that worked. One of them had the Peyronie's [disease] where it tilts to one side, and it got straightened out.

Dr Shirin Lakhani, the founder of Elite Aesthetics, started offering penis enhancements with blood plasma back in 2014. Stem-cell treatments are far harder to access in the UK due to medical guidelines, and, it has to be said, the greater propensity of British doctors to act in line with the clinical evidence base. Hundreds of clinics across the US offer a variety of stem-cell therapies, while only about 17 places in the UK provide the so-called P-shots. I'd get a handful of enquiries every week to start with, she recalls. Now we're absolutely inundated.

Dr Shirin Lakhani with a P-shot.

About one-in-five of patients that undergo the procedure dont get any improvements, but some get a 25% increase in girth and 20% increase in length for up to a year on average, and sometimes longer, she says. A great deal of importance has been placed on men by society in being able to have intercourse and perform, she says. I find it incredibly rewarding to be able to help. Giving people back their confidence, improving their lives and their wellbeing. It's just part of being a doctor.

However, many experts are concerned that there is not yet enough robust clinical data to support the growing use of these penile revamp therapies. As of January last year, the published papers on stem-cell therapy for erectile dysfunction included studies performed on fewer than 120 men. In a study on 17 men with perpetually flaccid penises, just under half recovered their erectile function thanks to stem cell injections. Subsequently, they were able to accomplish sexual intercourse. A study with 60 men had similar results, while a meta analysis including 12 human studies found that no major complications were reported in any of the trials.

There is also only preliminary research to prove the efficacy of shockwave therapy, which is a common treatment to dislodge kidney stones. A study in the Scandinavian Journal of Urology had 112 male participants, all of whom had erectile dysfunction and were unable to have sex without Viagra which many men do not respond to and even when it works can cause headaches and nausea. After five weekly low-intensity soundwave shocks along their penises, more than half of the test group were having sex again unaided. That compares to 9% of the placebo group. The treatment was christened as a shocking Viagra alternative.

In its most recent position paper on restorative therapies for erectile dysfunction, the Sexual Medicine Society of North America (SMSNA) acknowledged the treatments represent a promising technology, but warned the current published studies are limited and underpowered. Until larger, higher-quality studies are complete, restorative therapies should be reserved for clinical trials and not offered in routine clinical practice, SMSNA said.

Dr Leigh Turner, a bioethics expert from the University of California, says outfits are persistently making bold marketing claims to attract clients without the clinical evidence to back them up, which is a recipe for patients spending considerable amounts of money for little or no chance of clinical benefits beyond potentially transient placebo effects. Im worried about clinics exploiting the hopes, fears, and anxieties of patients, he says. Its very easy to take advantage of vulnerable individuals who are looking for help.

He warns that US businesses currently marketing stem-cell treatments for erectile dysfunction are often not staffed by urologists or other trained specialists. Rather, many such clinics are staffed by individuals that have no meaningful expertise in erectile dysfunction, urology or mens health.

Still, the desire to enhance the look and feel of ones penis has always been a male obsession. Despite the limited data, anecdotal reports of positive benefits make them a worthwhile risk for many. Thats buttressed by the fact that many athletes, including Tiger Woods and Rafael Nadal, have undergone stem-cell treatments on other parts of their body.

UFC bantamweight champion, Sean OMalley.

UFC bantamweight champion Sean OMalley was at a clinic in Mexico in 2022 to get stem-cell therapy to treat a recurring knee injury when he decided on a whim to get the injections in his penis, too. There's one guy there, and he's like, Yeah I'm getting my dick done, he recalled on his podcast. I think he had erectile dysfunction or something, and I'm like, Well, my wiener works perfectly fine. Is there any cons or is it just pros? The doctors told him it could help with girth, performance, explosive orgasms. So I'm like "Well, it ain't the first time I've had a needle in my wiener, hit me up doc." It was painful and there was serious bruising, but he claims his erect penis is now about four-inches bigger.

It was $5,000 well invested for Wells to ensure he could always get a healthy boner, too. His occasional inability to maintain an erection previously would, naturally, disrupt intimate moments and lead to frustration. It impacts your confidence, he says. I really feel Im living my best and most useful life now.

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Stem-Cell Penis Enlargement: Biohackers Increasing the Size of Their Penis - Men's Health UK

FDA approves Xolair as first and only medicine for children and adults with one or more food allergies

Basel, 16 February 2024 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that the U.S. Food and Drug Administration (FDA) has approved Xolair® (omalizumab) for the reduction of allergic reactions, including anaphylaxis, that may occur with accidental exposure to one or more foods in adult and paediatric patients aged 1 year and older with IgE-mediated food allergy. People taking Xolair for food allergies should continue to avoid all foods they are allergic to (commonly referred to as “food allergen avoidance”). Xolair should not be used for the emergency treatment of any allergic reactions, including anaphylaxis. Immunoglobulin E (IgE)-mediated food allergies are the most common type and are typically characterised by the rapid onset of symptoms following exposure to certain food allergens.3 Xolair is the first and only FDA-approved medicine to reduce allergic reactions in people with one or more food allergies. Xolair is widely available and can now be prescribed for appropriate patients with IgE-mediated food allergy in the U.S.

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FDA approves Xolair as first and only medicine for children and adults with one or more food allergies

Iovance Biotherapeutics to Host Conference Call and Webcast on Friday, February 16, 2024

SAN CARLOS, Calif., Feb. 16, 2024 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a biotechnology company focused on innovating, developing, and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer, will host a conference call and live audio webcast to discuss the FDA approval announced earlier today at 4:15 p.m. ET, February 16, 2024.

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Iovance Biotherapeutics to Host Conference Call and Webcast on Friday, February 16, 2024

Motus GI Holdings, Inc. Announces Adjournment of the February 16, 2024 Special Meeting of Stockholders

FORT LAUDERDALE, Fla., Feb. 16, 2024 (GLOBE NEWSWIRE) -- Motus GI Holdings, Inc. (“the Company”) (NASDAQ: MOTS), today announced that its special meeting of stockholders held on February 16, 2024 (the “Special Meeting”) was convened and then adjourned, without conducting any business, in order to provide stockholders additional time within which to vote on the proposal described in the Company’s definitive proxy statement filed with the Securities and Exchange Commission (the “SEC”) on January 24, 2024 (the “Proxy Statement”).

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Motus GI Holdings, Inc. Announces Adjournment of the February 16, 2024 Special Meeting of Stockholders