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Regenerative Medicine Market 2026: Product Approvals and Growing Pipeline of Regenerative Medicine P – PharmiWeb.com

By Stem Cell Medicine

Future Trends, Drivers & Opportunity: Rising Demand for Organ Transplantation, Implementation of the 21st Century Cures Act, Rising Government Investments in Regenerative Medicine Research, Rising Prevalence of Chronic Diseases and Genetic Disorders

Regenerative Medicine Market Analysis:

Global Regenerative Medicine Market was valued at USD 19.10 Billion in 2018 and is expected to witness a growth of 22.72% from 2019-2026 and reach USD 98.10 Billion by 2026.

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What is Regenerative Medicine Market?

The field of regenerative medicine comprises of abundant strategies, which mainly includes use of materials and de novo generated cells, as well as various amalgamations thereof, to substitute the lost tissue, efficiently replacing it both anatomically and functionally, or to contribute to tissue restoration. The main objective of regenerative medicine is to propagate replacement tissue or organs for patients who have sustained an injury or have had a disease that permanently damaged their tissue. National Institutes of Health defines regenerative medicine as a process of creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects.

Regenerative Medicine can be perceived as an interdisciplinary field of research and clinical applications which mainly focuses on the repair, replacement or regeneration of cells, tissues or organs. Regenerative Medicine mainly restores impaired function resulting from any cause. Regenerative medicine has the ability to rectify or substitute tissues and organs impaired by age, disease, or trauma, as well as to normalize congenital defects.

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Regenerative Medicine Market Outlook

Over the last decade, stem cell biology has experienced a breakthrough in scientific and technological developments that will together have foremost and continuing influence on regenerative medicine. These entails capability to produce pluripotent stem cells from adult body cells and to cultivate mini-organs from these or from adult stem cells in well-defined culture conditions. Both methodologies offer ways to develop functional cells of human tissue that could be used for transplantation and tissue repair.

Government policies favoring regenerative medicine is one of the major reasons which has been driving the market growth. The European Union (EU) and Dutch government have prioritized regenerative medicine as an area of key strategic relevance. Apart from this, rapid increase in aged population has also boomed the market in North American region. The North Carolina Tissue Engineering and Regenerative Medicine Society is an organization in the U.S. working to improve and advance basic research, commercial development and education in the field of regenerative medicine. In the U.S., two major government agencies NIH and CIRM gather funds for academic translational stem cell research and regenerative medicine development. Increasing global healthcare expenditure is also expected to fuel the market.

Lack of awareness and ethical issues regarding the use of Embryonic Stem Cell for R&D is expected to hinder the market for regenerative medicine. The market growth rate is highly influenced by the adoption rate of cell therapy in the market, as it is an integral part of regenerative medicine. After conducting a survey, following statistics were fetched in terms of major hindrances in stem cell research.

A survey was conducted and the respondents had above rating on a scale of 1-5, where 1 stands for not limiting and 5 stands for major limitation. Respondents rated Expense as the most limiting hindrance in stem cell research. Thus, high cost of investment could be one of the major restraints of the market followed by issues of assay sensitivity, robustness and reproducibility; difficulty of culture/propagation; and then difficulty of handling.

Global Regenerative Medicine Market Segmentation

The Global Regenerative Medicine Market is classified on the basis of Therapy, Product, Application and Region. The gist of breaking down the market into various segments is to gather the information about various aspects of the market. On the basis of Therapy, the market is bifurcated on the basis of Cell Therapy, Immunotherapy, Tissue Engineering, and Gene Therapy. The Cell Therapy is expected to be dominating in the market. The reason for this could be growing stem cell research and development.

In terms of Product, the market study encompasses various aspects such cell-based products and acellular products. Growing funding for new stem cell lines is boosting the growth of cell-based products in the global market. With growing R&D work occurring in Asian countries, the Asia Pacific region will grow at the fastest pace. Another reason for the growth rate could be rising awareness and establishments of bio-banks/stem cell banks.

Regenerative Medicine Market Competitive Landscape

The Regenerative Medicine Market study report offers a valuable insight with an emphasis on global market including some of the major players such as Organogenesis Inc., Osiris Therapeutics, Inc., Vericel Corporation, Stryker Corporation and NuVasive, Inc. Our market analysis also entails a section solely dedicated for such major players wherein our analysts provide an insight to the financial statements of all the major players, along with its product benchmarking and SWOT analysis. The competitive landscape section also includes key development strategies, market share and market ranking analysis of the above mentioned players globally.

Analyst View:

Since tissue engineering and regenerative medicine arose as an industry about two decades ago, a wide range of therapies have received Food and Drug Administration (FDA) authorization of commercial availability. Advent of stem cells have boomed the market for regenerative medicine. Geopolitical policies have increased the scope for regenerative medicine.

The case of Japan justifies the attention it has been getting lately. The Japans initiative that included the reform of law based on regenerative medicine is attracting business toward the country. The creation of the Forum for Innovative Regenerative Medicine (FIRM) in 2014, comprising 185 firms as of January 2016, and the participation of an increasing number of organizations from the United States, Canada, the United Kingdom, Sweden, and Australia, represented a significant breakthrough.

The field of regenerative medicine is expected to provide new opportunities bring numerous opportunities across. Various key industry players have come ahead to invest in regenerative medicine. The concept of regenerative medicine is actively being implemented in across various applications such as Oncology, Cardiology, Orthopedic & Musculoskeletal Disorders, etc.

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Regenerative Medicine Market 2026: Product Approvals and Growing Pipeline of Regenerative Medicine P - PharmiWeb.com

Mutations in donors’ stem cells may cause problems for cancer patients – Washington University School of Medicine in St. Louis

By Stem Cell Medicine

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Heart problems, graft-versus-host disease are concerns

A new study from Washington University School of Medicine in St. Louis suggests that bone marrow or blood stem cells from healthy donors can harbor extremely rare mutations that can cause health problems for the cancer patients who receive them. Such stem cell transplants are important for treating blood cancers, including acute myeloid leukemia. In the healthy bone marrow pictured, mature red blood cells are shown as small brownish-pink discs; red blood cells that are still developing are in deep blue; and developing white blood cells are in lighter blue.

A stem cell transplant also called a bone marrow transplant is a common treatment for blood cancers, such as acute myeloid leukemia (AML). Such treatment can cure blood cancers but also can lead to life-threatening complications, including heart problems and graft-versus-host disease, in which new immune cells from the donor attack a patients healthy tissues.

A new study from Washington University School of Medicine in St. Louis suggests that extremely rare, harmful genetic mutations present in healthy donors stem cells though not causing health problems in the donors may be passed on to cancer patients receiving stem cell transplants. The intense chemo- and radiation therapy prior to transplant and the immunosuppression given after allow cells with these rare mutations the opportunity to quickly replicate, potentially creating health problems for the patients who receive them, suggests the research, published Jan. 15 in the journal Science Translational Medicine.

Among the concerns are heart damage, graft-versus-host disease and possible new leukemias.

The study, involving samples from patients with AML and their stem cell donors, suggests such rare, harmful mutations are present in surprisingly young donors and can cause problems for recipients even if the mutations are so rare as to be undetectable in the donor by typical genome sequencing techniques. The research opens the door to a larger study that will investigate these rare mutations in many more healthy donors, potentially leading to ways to prevent or mitigate the health effects of such genetic errors in patients receiving stem cell transplants.

There have been suspicions that genetic errors in donor stem cells may be causing problems in cancer patients, but until now we didnt have a way to identify them because they are so rare, said senior author Todd E. Druley, MD, PhD, an associate professor of pediatrics. This study raises concerns that even young, healthy donors blood stem cells may have harmful mutations and provides strong evidence that we need to explore the potential effects of these mutations further.

Added co-author Sima T. Bhatt, MD, an assistant professor of pediatrics who treats pediatric patients with blood cancers at Siteman Kids at St. Louis Childrens Hospital and Washington University School of Medicine: Transplant physicians tend to seek younger donors because we assume this will lead to fewer complications. But we now see evidence that even young and healthy donors can have mutations that will have consequences for our patients. We need to understand what those consequences are if we are to find ways to modify them.

The study analyzed bone marrow from 25 adult patients with AML whose samples had been stored in a repository at Washington University. Samples from their healthy matched donors, who were unrelated to the patients, also were sequenced. The donors samples were provided by the Center for International Blood and Marrow Transplant Research in Milwaukee.

The 25 AML patients were chosen because they each had had samples banked at four separate times: before the transplant, at 30 days post-transplant, at 100 days post-transplant, and one year post-transplant.

Druley co-invented a technique called error-corrected sequencing, to identify extremely rare DNA mutations that would be missed by conventional genome sequencing. Typical next-generation sequencing techniques can correctly identify a mutation that is present in one in 100 cells. The new method, which can distinguish between true mutations and mistakes introduced by the sequencing machine, allows the researchers to find true mutations that are extremely rare those present in as few as one in 10,000 cells.

The healthy donors ranged in age from 20 to 58, with an average age of 26. The researchers sequenced 80 genes known to be associated with AML, and they identified at least one harmful genetic mutation in 11 of the 25 donors, or 44%. They further showed that 84% of all the various mutations identified in the donors samples were potentially harmful, and that 100% of the harmful mutations present in the donors later were found in the recipients. These harmful mutations also persisted over time, and many increased in frequency. Such data suggest the harmful mutations from the donor confer a survival advantage to the cells that harbor them.

We didnt expect this many young, healthy donors to have these types of mutations, Druley said. We also didnt expect 100% of the harmful mutations to be engrafted into the recipients. That was striking.

According to the researchers, the study raises questions about the origins of some of the well-known side effects of stem cell transplantation.

We see a trend between mutations from the donor that persist over time and the development of chronic graft-versus-host disease, said first author Wing Hing Wong, a doctoral student in Druleys lab. We plan to examine this more closely in a larger study.

Though the study was not large enough to establish a causal link, the researchers found that 75% of the patients who received at least one harmful mutation in the 80 genes that persisted over time developed chronic graft-versus-host disease. Among patients who did not receive mutations in the 80 genes, about 50% developed the condition. Because the study was small, this difference was not statistically significant, but it is evidence that the association should be studied more closely. In general, about half of all patients who receive a stem cell transplant go on to develop some form of graft-versus-host disease.

The most common mutation seen in the donors and the cancer patients studied is in a gene associated with heart disease. Healthy people with mutations in this gene are at higher risk of heart attack due to plaque buildup in the arteries.

We know that cardiac dysfunction is a major complication after a bone marrow transplant, but its always been attributed to toxicity from radiation or chemotherapy, Druley said. Its never been linked to mutations in the blood-forming cells. We cant make this claim definitively, but we have data to suggest we should study that in much more detail.

Added Bhatt: Now that weve also linked these mutations to graft-versus-host disease and cardiovascular problems, we have a larger study planned that we hope will answer some of the questions posed by this one.

This work was supported by the National Cancer Institute (NCI) of the National Institutes of Health (NIH), grant number R01CA211711; the Hyundai Quantum Award; the Leukemia and Lymphoma Society Scholar Award; the Eli Seth Matthews Leukemia Foundation; and the Kellsies Hope Foundation. The Center for International Blood and Marrow Transplant Research is supported by a Public Health Service Grant/Cooperative Agreement from the NCI, the National Heart, Lung and Blood Institute (NHLBI), and the National Institute of Allergy and Infectious Diseases (NIAID), grant number 5U24CA076518; a Grant/Cooperative Agreement from NHLBI and NCI, grant number 1U24HL138660; a contract with Health Resources and Services Administration (HRSA/DHHS), number HHSH250201700006C; and the Office of Naval Research, grant numbers N00014-17-1-2388, N00014-17-1-2850 and N00014-18-1-2045. Support also was provided by a UKRI future leaders fellowship and by a CRUK Cambridge Centre Early Detection Programme group leader grant.

The Washington University Office of Technology Management has filed a patent application for Ultra-rare Variant Detection from Next-generation Sequencing, which has been licensed by Canopy Biosciences as RareSeq. Druley is a coinventor on this patent. Canopy Biosciences was not involved in the generation of the data presented.

Wong WH, Bhatt S, Trinkaus K, Pusic I, Elliott K, Mahajan N, Wan F, Switzer GE, Confer DL, DiPersio J, Pulsipher MA, Shah NN, Sees J, Bystry A, Blundell JR, Shaw BE, Druley TE. Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation. Science Translational Medicine. Jan. 15, 2020.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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Mutations in donors' stem cells may cause problems for cancer patients - Washington University School of Medicine in St. Louis

Global Cell Expansion Market by Type, Share Analysis, Top Players Eyeing to Penetrate Into Emerging Nations with Untapped Opportunities 2024 …

By Stem Cell Medicine

Executive Summary

A comprehensive research report created through extensive primary research (inputs from industry experts, companies, stakeholders) and secondary research, the report aims to present the analysis of cell expansion market. The report analyses the Global Cell Expansion Market: Analysis By Product Type (Instruments, Consumables, Disposables), By Cell Type (Human Cell and Animal Cell), By Application (Regenerative Medicine and Stem Cell Research and Cancer and Cell Based Research), By Region (North America, Europe, Asia Pacific, South America, and Middle East and Africa), (U.S, Canada, Germany, France, U.K., Japan, China, India): Opportunities and Forecast (2019 Edition): Forecast to 2024, for the historical period of 2018-2019 and the forecast period of 2019-2024.

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According to research report Global Cell Expansion Market: Analysis By Product Type (Instruments, Consumables, Disposables), By Cell Type (Human Cell and Animal Cell), By Application (Regenerative Medicine and Stem Cell Research and Cancer and Cell Based Research), By Region (North America, Europe, Asia Pacific, South America, and Middle East and Africa), (U.S, Canada, Germany, France, U.K., Japan, China, India): Opportunities and Forecast (2019 Edition): Forecast to 2024-, the cell expansion market is projected to display a robust growth represented by a CAGR of 17.33% during 2019 2024.

Over the recent years, cell expansion market has been witnessing considerable growth directly on the back of increasing prevalence of chronic diseases such as cancer, diabetes, osteoarthritis, etc. Moreover, factors such as increasing investment in healthcare research, growing government initiatives, increasing adoption rate of new and technically instruments, rapidly evolving applicable segment market has been providing momentum to the overall market growth of cell expansion.

In addition, increasing demand for technically advanced products such as automated cell expansion systems and increasing number of cell GMP-certified cell expansion facilities are anticipated to fuel the market growth in forecasted period. However, recalls due to product failures have been hindering the market growth.

The report titled Global Cell Expansion Market: Analysis By Product Type (Instruments, Consumables, Disposables), By Cell Type (Human Cell and Animal Cell), By Application (Regenerative Medicine and Stem Cell Research and Cancer and Cell Based Research), By Region (North America, Europe, Asia Pacific, South America, and Middle East and Africa), (U.S, Canada, Germany, France, U.K., Japan, China, India): Opportunities and Forecast (2019 Edition): Forecast to 2024:-has covered and analysed the potential of cell expansion market and provides statistics and information on market size, shares and growth factors. The report intends to provide cutting-edge market intelligence and help decision makers take sound investment evaluation. Besides, the report also identifies and analyses the emerging trends along with major drivers, challenges and opportunities. Additionally, the report also highlights market entry strategies for various companies.

More about Report:https://www.marketwatch.com/press-release/global-cell-expansion-market-by-type-industry-size-share-analysis-top-players-eyeing-to-penetrate-into-emerging-nations-with-untapped-opportunities-2024-2020-01-07

Scope of the ReportGlobal Cell Expansion Market (actual period:2014-2018)(forecast period:2019-2024)Cell Expansion Market Size, Growth, Forecast Analysis By Product Type: Instruments, Consumables, Disposables. Analysis By Cell Type: Human Cells and Animal Cells. Analysis By Application Type: Regenerative Medicine and Stem Cell Research and Cancer and Cell Based Research.

Regional Cell Expansion Market North America, Europe, Asia Pacific, South America, and Middle East and Africa (actual period:2014-2018)(forecast period:2019-2024)Cell Expansion Market Size, Growth, Forecast Analysis By Product Type: Instruments, Consumables, Disposables. Analysis By Cell Type: Human Cells and Animal Cells. Analysis By Application Type: Regenerative Medicine and Stem Cell Research and Cancer and Cell Based Research.

Country Cell Expansion Market U.S., Canada, Germany, U.K, France, China, Japan, India (actual period:2014-2018)(forecast period:2019-2024)Cell Expansion Market Size, Growth, Forecast Analysis By Product Type: Instruments, Consumables, Disposables. Analysis By Cell Type: Human Cells and Animal Cells. Analysis By Application Type: Regenerative Medicine and Stem Cell Research and Cancer and Cell Based Research.

Browse Full report @https://www.orbisresearch.com/reports/index/global-cell-expansion-market-analysis-by-product-type-instruments-consumables-disposables-cell-type-by-application-by-region-by-country-2019-edition-opportunities-and-forecast-2014-2024-by-application-by-region-by-country

Other Report HighlightsMarket Dynamics Drivers and Restraints.Market Trends.Porter Five Forces Analysis.SWOT Analysis.Company Analysis Merck Millipore, Eppendorf, ThermoFisher Scientific, Becton Dickinson, Danaher Corporation, Corning Inc., Terumo Medical Corporation, CellGenix Technologie Transfer GmbH, Synthecon Inc., Stem Cell Technologies Inc.

Customization of the Report

The report could be customized according to the clients specific research requirements. No additional cost will be required to pay for limited additional research.

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Global Cell Expansion Market by Type, Share Analysis, Top Players Eyeing to Penetrate Into Emerging Nations with Untapped Opportunities 2024 ...

Introducing Generate Life Sciences – A First-Of-Its-Kind Company Focused On Helping Grow And Protect Healthy Families – PRNewswire

By Stem Cell Medicine

Generate serves families from preconception to post-birth throughout the significant and highly personalized journey of building a family and protecting their children's health. Built upon the pillars of innovation, access, and connection, Generate has already helped grow and protect nearly 1 million families around the world.

Our legacy brands CBR, California Cryobank, and Donor Egg Bank USA are pioneering leaders in their respective fields and continue to set industry standards for innovation, scientific excellence, and customer focus. Generate is furthering the impact of this life sciences platform with the addition of advanced pediatric genetic testing, US distribution of reproductive medical devices and proprietary healthcare technology through the respective brands ReadyGen (pediatric genetic screening powered by Sema4), Kitazato USA (medical device distribution), and Donor Application (proprietary software for reproductive clinics).

"Our brands are leaders in each of their categories; as a life sciences platform, we are uniquely positioned to give clients access to the full range of expertise and services needed to create and support healthy families," said Richard Jennings, Chief Executive Officer. "Generate helps its clients realize their dreams of having a baby and provides access to scientific innovations in stem cells and genetic services that improve the lives of families around the world."

With the substantial growth in single parenting by choice and LGBTQ+ family building, as well as a trend towards having children later in life, Generate's reproductive health services have never been in higher demand. Similarly, advances in stem cell therapies and research into regenerative medicine have emphasized the importance and increased the awareness and interest in storing newborn stem cells with CBR.

"Generate Life Sciences is positioned to play an increasingly important role in protecting families as regenerative medicine and new genetic testing platforms open the door to the future of personalized medical treatments," said Jaime Shamonki, MD, Chief Medical Officer. "Uniting key elements of the family-building experience under Generate will give our clients peace of mind, convenient access, and exceptional support throughout this significant time in their lives. This organization has collectively helped create nearly 100,000 families and provides access to invaluable long-term health benefits to almost a million more. For us, Generate represents more than just good business; it is advancing scientific innovations that help the future of humanity."

"The journey to parenthood has evolved over the years, but the end goal is the same people want to have children and they want to keep them safe and healthy. In the modern age, we have advanced the science and technology available to help individuals grow their families and be more proactive in planning for their future health," said Michael J. Levy, MD, IVF Director and Co-Founder, Shady Grove Fertility. "That is where Generate Life Sciences becomes a trusted partner for clients from pre-conception through post-birth. From donor egg and donor sperm to newborn stem cell services and genetic testing, Generate is there every step of the way. And the possibilities are endless."

"Generate Life Sciences made our dream of becoming parents a reality. From helping us choose our amazing California Cryobank sperm donor for our twin girls, to rushing a CBR cord blood collection kit for our son when my wife went into early labor, they have always gone above and beyond to help. We look to Generate as a trustworthy partner we can rely on for these very personal and private moments in our lives," said Sharon Kochlany & Vanessa Colimorio, customers of Generate.

Generate Life Sciences BrandsGenerate Life Sciences is a company of established, trustworthy brands founded and grown over 40 years by experts in reproductive medicine, newborn stem cell services, and genetics. Those brands include:

Newborn Stem Cell Services CBR (Cord Blood Registry): CBR has stored newborn stem cells (stem cells collected from cord blood and cord tissue) for almost 30 years.

Reproductive ServicesCalifornia Cryobank Donor Sperm Bank:California Cryobank is a pioneer and industry leader in donor sperm banking, offering the most rigorously screened donors, largest selection, and scientific expertise for more than 40 years.

Donor Egg Bank USA:Donor Egg Bank is a true leader in its category, maintaining the highest clinical pregnancy rate in the industry, while growing the largest frozen donor egg program in the United States.

NW Cryobank:For over 30 years, NW Cryobank has been helping couples, single women, and the LGBTQ+ community create happy, healthy families.

Genetic Services ReadyGen:Powered by Sema4, ReadyGen is an innovative and advanced pediatric screening test that empowers parents to further protect their children by delivering clinically actionable and personalized health insights.

Medical Devices and Healthcare TechnologyKitazato USA:Kitazato USA by California Cryobank is the exclusive distributor of Kitazato products in the US, offering devices for human assisted reproductive medicine from the innovator of the Cryotop Method vitrification technique.

Donor Application: Proprietary software providingdonor screening and recipient matching services on a HIPAA compliant platform.

About Generate Life SciencesGenerate Life Sciences (Generate)is a life sciences company helping to grow and protect families through reproductive, newborn stem cell, genetic screening, medical device, and healthcare technology services. We serve families from preconception to post-birth. Our brands - CBR (Cord Blood Registry), California Cryobank Donor Sperm Bank, Donor Egg Bank USA, NW Cryobank, ReadyGen, Kitazato USA, and Donor Application are pioneering leaders, helping to grow and protect nearly 1 million families. Headquartered in Los Angeles, Generate operates facilities in Tucson, New York, Boston, Palo Alto, and Rockville, MD. Generate is a portfolio company of GI Partners, a private investment firm based in San Francisco.

Media ContactsMonica Rohledermedia@generatelifesciences.com847-606-1973

SOURCE Generate Life Sciences

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Introducing Generate Life Sciences - A First-Of-Its-Kind Company Focused On Helping Grow And Protect Healthy Families - PRNewswire

Botox, medical drips and more offered at NVY Center – SILive.com

By Stem Cell Medical Center

STATN ISLAND, N.Y. -- As a Manhattan-based attorney, Chris Cardillo has overseen his share of medical management over the years.

Paperwork involved with being a doctor is so overwhelming these days, he said, noting that many physicians turn to attorneys to help manage their practices.

So with a wide knowledge of the medical industry, he sought to open a business that would house different physicians, as well as spa services, in a medical spa setting under one roof.

The result is NVY Center, a medical management company that opened in Richmond Valley more than one year ago.

As a Manhattan-based attorney, Chris Cardillo has completed his share of medical management over the years. Paperwork involved with being a doctor is so overwhelming these days, he said, noting that many physicians turn to attorneys to help manage their practices. (Staten Island Advance/Tracey Porpora)

I became very interested in the concept because I think its the wave of the future, said Cardillo, who has several partners in the business. Almost every medical office has a medical manager. ...When you go to a hospital, like New York University Medical Center, the hospital does all the management for doctors with affiliated practices. What hospitals do for their doctors, we do on a private level.

MEDICAL, SPA SERVICES UNDER ONE ROOF

NVY Center rents a clean, white expansive space to various medical professionals, and aestheticians, who provide spa services.

We are hoping to be a national brand. What we do is solicit doctors to lease space for us and we manage them. That means when a doctor comes in here the only thing the doctor has to worry about is taking care of the patient, said Cardillo. We take care of the billing. They dont have to do any of the paperwork. Everything they need to do their job is here for them already.

Under the NVY Center roof are an array of spa services -- from stem cell therapy and IV drips to facials and aesthetic injections. (Staten Island Advance/Tracey Porpora)

MEDICAL SPA SERVICES

Under the NVY Center roof are also an array of medical spa services, from stem cell therapy and IV drips, to facials and aesthetic injections.

Included in the facilitys design are individual medical offices, rooms where different procedures, such as facials, can take place, and an IV drip chair area. And the facility always has a medical professional on the premises, said Cardillo.

We do everything from anti-hangover to anti-flu drip. ... Soon, well be able to come to your house and do an IV drip, explained Cardillo. We want this to be a one-stop-shop for modern services."

He noted the IV drips often include vitamins and are used for various purposes, including by those people who desire to lose weight.

We have fast-drips that are 15 minutes long, where we can fill you with fluids if youre not feeling good, said Cardillo. Depending on what were trying to treat, we will mix vitamins and other medicines into the IV drip. But the fluid helps no matter what.

He said the company also hosts IV drip and Botox parties.

Other services include Trusculpting," a fat reduction procedure to lose weight, and laser hair removal, said Cardillo.

NVY CENTER AT A GLANCE

Address: 236 Richmond Valley Rd.

Website: http://www.nvycenter.com

Facebook: http://www.facebook.com/nvycenter/

New Businesses in Focus is a weekly column that relates the stories of new Staten Island businesses owners.

If you have a new business on Staten Island, e-mail porpora@siadvance.com.

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Botox, medical drips and more offered at NVY Center - SILive.com

Walter named Edward P. Evans Endowed Professor – Washington University School of Medicine in St. Louis

By Stem Cell Medical Center

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Oncologist honored for research, patient care in myelodysplastic syndromes

Medical oncologist Matthew Walter, MD, presents his research after being installed as the inaugural Edward P. Evans Endowed Professor of Myelodysplastic Syndromes at Washington University School of Medicine in St. Louis.

Matthew J. Walter, MD, has been named the inaugural Edward P. Evans Endowed Professor of Myelodysplastic Syndromes at Washington University School of Medicine in St. Louis. These syndromes make up a group of rare blood disorders that prevents the body from making sufficient healthy blood cells.

Walter, an international leader in the study and treatment of myelodysplastic syndromes (MDS), is a professor of medicine and director of the Edward P. Evans Center for Myelodysplastic Syndromes at the School of Medicine. The endowed professorship and the center are supported by funding from the Edward P. Evans Foundation, established in 1984 by Edward Parker Evans, a businessman and philanthropist whose foundation supports MDS research nationwide. He died in 2010 from a blood cancer related to MDS.

Walter treats patients with MDS and related blood disorders at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine. His new professorship was announced by Chancellor Andrew D. Martin and David H. Perlmutter, MD, executive vice chancellor for medical affairs, the George and Carol Bauer Dean of the School of Medicine, and the Spencer T. and Ann W. Olin Distinguished Professor.

Matthew Walter has devoted his career to the study and treatment of myelodysplastic syndromes, and it is a great pleasure to be able to honor his work and commitment to his patients in this way, Martin said. There is no one better suited to lead this center. This endowed professorship will help support his work to understand the genetic and environmental underpinnings of this disease so that researchers can understand how it develops and work toward developing improved precision therapies to prevent or treat MDS.

Some 40,000 Americans are diagnosed with MDS each year. The symptoms can be vague, including shortness of breath and fatigue, which makes it difficult to diagnose. Low blood cell counts are among the first signs of the disease, and patients are diagnosed based on the appearance of abnormal blood cells. MDS can be fatal, but some patients with low-risk MDS live for many years with the disease and never know they have it. About one-third of patients with MDS develop an aggressive form of the disease that progresses to acute myeloid leukemia (AML), which is a fast-growing blood cancer. Without a successful stem cell transplant, AML is fatal.

Walter is interested in studying patients at risk of developing MDS but who dont yet have the disease. Such patients have mutations in a few important genes linked to MDS but dont yet have symptoms. This condition is called age-related clonal hematopoiesis. Even though relatively few of these patients go on to develop MDS, studying this group of patients could help doctors understand the differences between those who develop MDS and those who dont.

The work that Matthew Walter is leading at the new Edward P. Evans MDS Center, including his work with patients, is the epitome of precision medicine, Perlmutter said. This research will help illuminate what leads patients to progress to MDS or more aggressive blood disorders. His vision includes developing ways to prevent this progression, as well as novel therapies, including immunotherapy strategies. It is a great pleasure to recognize the innovative work Matthew Walter is doing to better care for these patients.

Said Victoria J. Fraser, MD, the Adolphus Busch Professor of Medicine and head of the Department of Medicine: Matthew Walter is a leader in the field in harnessing his labs research discoveries for the benefit of his patients. This professorship will help him continue his important research into the origins of this disease and potential ways to prevent and treat it.

Walter earned his bachelors degree in 1990 from American University in Washington and his medical degree in 1995 from Saint Louis University School of Medicine. He was a research scholar at the Howard Hughes Medical Institute and later completed his internship and residency at Johns Hopkins Hospital. He came to Washington University as a hematology-oncology fellow and joined the faculty in 2004.

Matthew Walter, MD, (center) shakes hands with Washington University Chancellor Andrew D. Martin as Victoria J. Fraser, MD, head of the Department of Medicine, applauds Walters installation as the inaugural Edward P. Evans Endowed Professor of Myelodysplastic Syndromes.

He has been honored with numerous awards, including the Leukemia and Lymphoma Society Scholar Award, the MDS Foundation Young Investigator Award, and the American Society of Hematology Scholar Award. He is an elected member of the American Society for Clinical Investigation, and he serves on the National MDS Steering Committee of the National Institutes of Health (NIH), and on the American Society of Hematology Task Force on Precision Medicine. He is the 2019 chair of the American Society of Hematology Scientific Committee on Myeloid Neoplasia.

Edward Parker Evans ran Spring Hill Farm, the largest thoroughbred breeding farm in Virginia. Since his death, the Edward P. Evans Foundation has supported cutting-edge translational research on MDS at leading institutions across the country, including Washington University, which is noted for its innovative research and leadership in developing new therapies for patients with cancerous disorders of the blood.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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Walter named Edward P. Evans Endowed Professor - Washington University School of Medicine in St. Louis

Who are the 10 Most Innovative Biopharma Companies? – BioSpace

By Stem Cell Medical Center

As the annual JP Morgan Healthcare Conference draws to a close, lets celebrate the remarkable innovation that drives the biopharma industry. Heres a look at the top 10 companies noted in the BioSpace Ideal Employer 2019 survey for being the most innovative and what theyve been up to recently.

Regeneron Pharmaceuticals. Ranked as the top innovator in the survey, Regeneron has long had a reputation for innovation, and is often cited as Sanofis innovation engine because of its numerous collaborations with the French-based company. Regeneron has seven marketed products, including Arcalyst for rare autoinflammatory disease, Eylea for a common cause of blindness, Praluent for high cholesterol, and Dupixent for atopic dermatitis. It also has REGN-EB3, a three-antibody therapy used to treat Ebola.

On January 9, Regeneron announced results from LUMINA-1, a Phase II trial of garetosmab in patients with fibrodysplasia ossificans progressive (FOP), an ultra-rare genetic disorder that leads to abnormal bone formation. After 28 weeks, the drug decreased total lesion activity compared to placebo by 25%.

Verily Life Sciences. Formerly known as Google Life Sciences, Verily is Alphabets life science research company. It was originally a division of Google X. At this point, the company doesnt have any marketed products and its not completely clear on the companys overall focus. It has numerous partnerships, such as one with Sanofi to develop products for managing diabetes, a disease-detecting nanoparticle platform called project Tricorder, and a partnership with Johnson & Johnson on surgical robotics. It also has partnerships with Alon, 3M, Allergan, Biogen, Dexcon, GlaxoSmithKline, Mayo Clinic, Brigham and Womens Hospital and many others.

On December 23, 2019, Verily partnered with Emory Healthcare to deploy new solutions to help improve cost-effectiveness, operational efficiency and quality. This deal with utilize Emorys academic medical center and partner with Verilys expertise in data science, analytics, user experience and product development. The initial focus is a deep analysis of existing drugs and lab-ordering patterns at Emory.

Illumina. Illumina develops, manufactures, and markets laboratory devices, with particular emphasis on DNA sequencing, genotyping, gene expression and proteomics. On January 4, 2020, Illumina announced a 15-year, non-exclusive deal with Roche. Not only will that increase the availability of next-generation sequencing-based in vitro diagnostic (IVD) tests on Illuminas systems, but the two companies will collaborate to complement Illuminas pan-cancer assay TruSight Oncology 500 (TSO 500) with new companion diagnostic (CDx) claims.

That deal came only a short time after Illumina canceled a $1.2 billion merger with another next-generation sequencing company, Pacific Biosciences (PacBio). Illumina decided the deal was not likely to be approved by antitrust regulators in the U.S. and UK. Illumina holds about 80% of the global DNA sequencing market.

bluebird bio. Bluebird bio focuses on the nascent field of gene therapy. Currently its sole approved product is Zynteglo. It was approved by the European Commission (EC) on June 14, 2019 for patients 12 years or older with transfusion-dependent beta-thalassemia who did not have a 0/0 genotype and for patients where hematopoietic stem cell (HSC) transplantation wasnt appropriate, but a human leukocyte antigen (HLA-matched related HSC donor isnt available. Its a little difficult to mention bluebird without mentioning the price of Zynteglo, which is $1.8 million in Europe. In addition to its scientific innovation, bluebird bio is innovative in terms of pricing structure. Zynteglos price is spread out over five years, with an initial upfront price of 315,000 euros with the four additional yearly payments due only if the treatment continues to work.

The product launched in Germany on Jan. 13, 2020. Bluebird initiated the rolling Biologics Licensing Application for Zynteglo in the U.S. and is currently in discussions with the U.S. Food and Drug Administration (FDA) on the timing and various components of the submission. They hope to complete the BLA submission in the first half of this year.

Biogen. Biogen specializes in therapies for central nervous system disorders. Some of its most well-known products are Alprolix for hemophilia B, Avonex, Fampyra, Tecfidera and Tysabri for multiple sclerosis, and Spinraza for spinal muscular atrophy (SMA). However, most recently, the company has been in the headlines for its aducanumab for Alzheimers disease. The drug was declared a failure in March 2019, but was resurrected this year after some of the later trial data showed effectiveness at the highest dose. Still, its not a slam dunk to be approved by the FDA and there are plenty of skeptics.

Analysts expect Biogen to submit aducanumab to the FDA in a matter of weeks, although the company is being tight-lipped about the timetable.

Bayer. Based in Germany, Bayer is one of the largest pharma companies in the world. In 2018, Bayer acquired U.S.-based Monsanto, which no longer exists under the Monsanto name. The companys business units include Bayer Crop Science, Consumer Health, Pharmaceuticals, Animal Health and Business Services.

On Jan. 16, 2020, Bayer sold one of its last Germany-based manufacturing facilities to Shanghai, China-based WuXi Biologics. The plant will be run by WuXi Biologics and act as a backup site for the manufacture of Bayers Kovaltry (antihemophilic factor). The primary site for Kovaltry product is Bayers facility in Berkeley, California.

Novartis. Based in Switzerland, Novartis has a well-known portfolio of drugs, including Clozaril, Voltaren, Tegretol, Diovan, Gleevec, and Ritalin. Its Sandoz Division is a global leader in generic drugs and biosimilars.

Last year, the FDA approved Zolgensma, a gene therapy for SMA, which was developed by its subsidiary, AveXis. Although there was some controversy over data manipulation in preclinical studies, it was determined not to affect the safety or efficacy of the therapy.

In late November 2019, Novartis acquired The Medicines Company for $9.7 billion, only a week after The Medicines Company announced positive data from its ORION-10 Phase III trial for inclisiran for lowering cholesterol.

GlaxoSmithKline. Headquartered in London, GSK markets drugs for numerous major diseases, such as asthma, cancer, infections, diabetes and mental health. Its best-known drugs include Advair, Augmentin, Flovent, Lamictal and others.

At the recent JP Morgan Healthcare Conference, Emma Walmsley, GSKs chief executive officer, predicted it will have six regulatory approvals in the U.S. this year.

I am pleased with the progress and the momentum that weve been able to make over the past couple years, she told CNBCs Jim Cramer.

Walmsley noted positive data for a number of programs, including ones gained from its $5.1 billion acquisition of Tesaro Oncology in 2018. She also noted a two-drug regimen for HIV that the companys subsidiary ViiV Healthcare has been developing.

Genentech. Generally viewed as the first modern biotechnology company, Genentech is a subsidiary of Swiss-based Roche, although Genentech is based in South San Francisco. It has a laundry list of successful drugs, often in the oncology market, such as Avastin, Tarceva, Zelboraf, Kadcyla, Alecansa, Venclexta and Tecentriq. It also has antivirals, such as Xofluza, Hemlibra for hemophilia A, and Esbriet for idiopathic pulmonary fibrosis.

On Dec. 12, 2019, Genentech announced that its Phase III IMspire150 trial in patients with previously untreated BRAF V600 mutation-positive advanced melanoma, hit its primary endpoint of progression-free survival (PFS). It showed adding Tecentriq to Cotellic and Zeleboraf decreased the risk of the disease getting worse or death, compared to placebo plus Cotellic and Zelboraf.

Amgen. Based in Thousand Oaks, California, Amgens best-selling products are Neulasta, an immunostimulatory for patients undergoing chemotherapy, and Enbrel, used to treat rheumatoid arthritis and other autoimmune diseases. Other products include Epogen, Aranesp, Prolia and XGeva.

On Nov. 1, 2019, the company expanded its presence in China by taking a 20.5% stake in China-based BeiGene Co. Amgen paid $2.7 billion in cash for the stake. As a result of the deal, BeiGene will commercialize Xgeva, Kyprolis and Blincyto in China.

On Jan. 13, 2020, the company inked strategic collaborations with Guardant Health and QIAGEN to develop blood- and tissue-based companion diagnostics for investigational cancer treatment AMG 510. AMG 510 is the first KRASG12C inhibitor to advance to the clinic for multiple cancer types.

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Who are the 10 Most Innovative Biopharma Companies? - BioSpace

HEALTH WATCH: What to know about, and how to treat, alopecia – Lexington Dispatch

By Platelet Rich Plasma Injections

Alopecia, or the loss of hair, can be triggered by various causes, including age, stress and an unhealthy lifestyle. [SHUTTERSTOCK]

The loss or thinning of hair can be a very traumatic experience for many, but there are ways to treat it

If one's hair begins to significantly thin out or fall out, it can be quite distressing for many. Alopecia, or hair loss, is a common condition that impacts men, women and even children.

Dr. Rosalyn George, a dermatologist and the founder of Wilmington Dermatology Center, 710 Military Cutoff Road, Suite 320, said alopecia is a daily complaint in her office and is a huge problem for many. She recommends that anyone who experiences significant hair loss get evaluated by a board-certified dermatologist.

1) Alopecia can appear as one or more circular bald patches, shedding of hair and gradual hair loss

"Alopecia is the technical term for hair loss, and it can present in many different ways depending on what's causing it," George said. "There are some autoimmune diseases where it will show up as a circular patch where all of your hair is gone. Most commonly people will notice a thinning or shedding of their hair, so they'll notice their hair is not quite as thick or that they're losing a lot more of their hair."

2) Alopecia types can be placed into two categories -- scarring alopecia and non-scarring alopecia

According to the National Institute or Arthritis and Musculoskeletal and Skin Diseases, scarring alopecia, also called cicatricial alopecia, is a group of rare disorders that destroy hair follicles, the part of the skin from which hair grows. Scar tissue replaces the follicles, causing permanent hair loss.

"It's very important to get that diagnosed early cause we (can) treat them before people have permanent hair loss," George said. "And then there are the non-scarring alopecias, which are the vast majority of alopecia that we see ...

"If someone's noticing significant hair loss, or if someone is having symptoms -- like some of the scarring hair loss will be itchy or have redness around the hair follicles, so there may be other things going on with that type of hair loss, so it's important to have a dermatologist evaluate you."

3) Telogen effluvium, androgenetic alopecia and alopecia areata are common types of alopecia

Non-scarring alopecia is the most common type of alopecia and include telogen effluvium, androgenetic alopecia and alopecia areata.

"The telogen effluvium happens in times of stress -- a good stress or a bad stress," George said. "For example, during pregnancy you kind of keep all of your hair, and then once you have the baby all of that hair will shed. That can happen after someone has surgery; I see it after someone has gastric bypass surgery, where their nutrition isn't great ..."

George calls androgenetic alopecia "extraordinarily widespread." It includes hair loss caused by aging. "That's the type of hair loss that men notice when they're starting to get the widow's peak, or they are going bald on the crown of their heads. It's very terrible for women when this happens because their hair starts to thin, and it can be very distressing psychologically to people.

"The third one is alopecia areata -- that's where people lose very well demarcated areas of hair or they can lose all of their hair on their scalp, or their body. There's different variations," she said. "Most of the times it's very localized, but there are more severe cases, where people can lose all of their hair on their body or just all of the hair on their head and face."

4) Alopecia can have various causes

According to the National Library of Medicine, many men and some women lose their hair as they get older. Hair loss can also be caused by underlying diseases, such as thyroid problems, diabetes, or lupus. Certain medications, types of chemotherapy, a stressful experience, diet, family history, and poor nutrition are some other causes.

"It's a mixture of genes, hormone changes, and environmental influences that cause hair loss over time and that is very, very common," George said about androgenetic alopecia.

Alopecia areata is an autoimmune condition, in which one's immune system basically attacks the hair follicles, which causes hair loss.

5) Treatment for alopecia depends on the cause

In some cases, treating the underlying cause can correct the problem. Other forms of treatment include medication and hair restoration techniques. One treatment for androgenetic alopecia includes Minoxidil, also known by brand name Rogaine. George said some vitamins can be helpful and some hair supplements have been linked to helping hair growth. However, she cautioned use of biotin, as excessive use of it can affect important lab work. A new therapy being used for hair loss is platelet-rich plasma injections, or PRP, where a person's blood is drawn, processed, and then injected into the scalp to help stimulate new hair growth.

George said, reducing stress, having a good diet, and getting enough sleep can all be helpful. Though trials are underway for oral medicines for people with alopecia areata, currently there are no approved medications for it.

As for telogen effluvium, George said, "all that takes is time. The hair recovers, and it grows back. It's not anything permanent, but it can be very stressful for people because you're shedding a lot of hair."

Contact the newsroom at 910-343-2384 or Breakingnews@StarNewsOnline.com.

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HEALTH WATCH: What to know about, and how to treat, alopecia - Lexington Dispatch

SVHI PRP Therapy Announces New Website Focused on PRP for Hair Loss in the San Francisco Bay Area – PR Web

By Platelet Rich Plasma Injections

PRP for Hair Loss Bay Area

FOSTER CITY, Calif. (PRWEB) January 17, 2020

SHVI PRP Therapy, the leader in innovative hair loss treatments based on PRP (Platelet Rich Plasma) at https://svhi-prp.com/, is proud to announce a new website. The new website is a "microsite," focused specifically at the use of PRP to mitigate hair loss. Many Bay Area consumers are open to cutting edge technologies, and PRP is one option in their hair loss journey.

"PRP therapy for hair loss is an innovative option for many Bay Area patients," explained Miguel Canales, surgeon and founder of SVHI PRP therapy. "Even more important, a patient who seeks out a consultation with me on hair loss will be able to review the entire range of options from PRP therapy to hair loss to hair transplantation. I will work with each patient to create the best treatment program for their hair loss needs."

Persons who would like to learn more about the company can visit the new website. In particular, they can focus on the page specific to PRP therapy can visit https://svhi-prp.com/prp-therapy/. Another option is to read the FAQ (Frequently Asked Questions) document at https://svhi-prp.com/faq/. That document explains as follows. Hair thinning in women, which affects nearly 40 million American women, is mainly due to heredity and can start any time after puberty. However, we also know that female pattern hair loss can be strongly influenced by age, nutrition, stress, surgery, medications, illness, social/lifestyle factors, hair care and more. As hair follicles weaken and stop producing hair, hair loss occurs. Remarkably, PRP for hair loss can impact the hair itself, often resulting in hair rejuvenation.

PRP or Platelet Rich Plasma for hair loss is an in-office, non-surgical, treatment derived from the patients own blood that can be performed in about an hour. After the area of concern is identified, evaluated and measured, standardized medical photos are taken in the photo suite. Special gentle and sterile techniques and equipment are used to separate and concentrate the platelets and plasma from a small sample of peripheral blood. PRP contains growth factors and cytokines that have been shown to be responsible for stimulating and enhancing hair follicle function. The scalp is prepared with antiseptic solution and anesthetic (a ring block, not simply local anesthetic gel) is used to completely numb the scalp. Small injections of the PRP deliver the powerful platelet-derived growth factors into the skin at the level of the weak follicles. Electronic, mechanical microneedling is performed.

ABOUT SVHI PRP THERAPY

SVHI PRP Therapy is a Bay Area company based in Foster City, California, that offers PRP for hair loss to clients from San Francisco to San Mateo, Palo Alto to Redwood City, Redwood City to Burlingame and beyond. Clients who are suffering from hair loss and are seeking innovative therapy come to SVHI PRP Therapy to explore their options, including PRP therapy for hair loss. The company offers a no obligation consultation on hair loss with Dr. Miguel Canales, a recognized specialist in the hair loss industry including hair transplantation.

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SVHI PRP Therapy Announces New Website Focused on PRP for Hair Loss in the San Francisco Bay Area - PR Web

Global Stem Cell and Platelet Rich Plasma (PRP) Alopecia Therapies Market 2019 Valuable Growth Prospects and Upcoming Trends till 2024 Dagoretti News…

By Stell Cell Research

Industry Research Report On GlobalStem Cell and Platelet Rich Plasma (PRP) Alopecia TherapiesMarket Quantitative And Qualitative Analysis

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Crucial leading players of industry:Orange County Hair Restoration Center, Colorado Surgical Center & Hair Institute, Evolution Hair Loss Institute, Hair Sciences Center of Colorado, Hair Transplant Institute of Miami, Anderson Center for Hair, Virginia Surgical Center, Savola Aesthetic Dermatology Center,

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