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Girl, 3, dies in her parents arms on New Years Day after leukaemia battle – The Sun

A LITTLE girl who won the backing of thousands of strangers online died of leukaemia on New Year's Day.

Esme Handley was just three years old when she passed away.

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The adorable tot was diagnosed with blood cancer at just 22 months, after developing a bruise while she was on a family holiday in Greece.

Her parents Rebecca and Will broke the heartbreaking news on their daughter's Facebook Page, named Esme Lionheart after her love of lions.

They said: If you look to the sky tonight you will see a star shining brighter than any other.

Our darling girl went onwards with her journey at midday today.

"She was peaceful and in our arms and knew how ridiculously adored she was.

Esme Grace Angela Handley 13.08.2016 - 01.01.2020.

Rebecca, 38, and Will, 43, faced a battle to try and save their only daughter following her diagnosis.

They discovered she had the high risk acute myeloid leukaemia during a family trip to Greece before which Esme fell.

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When a bruise that developed shortly afterwards failed to disappear, the couple Googled Esme's symptoms and became concerned.

She was taken to hospital in Greece where the diagnosis was confirmed.

Esme was given a stem cell transplant in September 2018 alongside three rounds of chemotherapy but after six months the leukaemia returned in the tots bone marrow.

If you look to the sky tonight you will see a star shining brighter than any other. Our darling girl went onwards with her journey at midday today.

The family were not eligible for a second transplant on the NHS and were faced with raising 500,000 privately for the urgent treatment.

In November, her parents admitted that Esme could no longer expect to be cured and said their baby had simply had enough.

They said: Since diagnosis we have often spoken about a metaphorical 'sealed envelope' that contains Esme's fate.

"Yesterday we got to open that envelope and it was not what we had hoped.

The leukaemia is out of control and there is nothing more which can be done.

We have spoken with every single, leading paediatric consultant globally, tried all available drugs (some of which arent even licensed in kids), explored a ridiculous amount of supplements and complementary medicines, had healing circles far and wide sending prayers.....

But its not been enough. We dont get to keep our baby.

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And to be perfectly honest, even if there was something else they could come up with, right now, Im not sure we would be able to pursue it.

"Its very clear to see that Esme has simply had enough....and who could blame her?

Esme thrives when shes outdoors but all she has known for 18 months is hospitals. The treatment she has had wouldnt be tolerated by most adults.

She has been continually pumped full of drugs; had hundreds of blood transfusions; successfully come through one stem cell transplant; had surgery for three Hickman lines into her heart; had numerous tubes shoved up her nose and drops in her eyes, suffered countless horrendous infections including a type of pneumonia three times; lost her hair; lost her fingernails; vomited daily, had her skin break down, crack, be burnt from chemo; nearly died from sepsis; almost died from anaphylaxis; been blue-lighted to PICU after having a seizure which temporarily left her in a vegetative state thanks to a fungal brain infection....and it goes on.

Whilst we would do absolutely anything for her, ANYTHING, Im also not sure how much more we can tolerate either.

A month later, they described the heartbreaking cocktail of pain management Esme had to bear to soften her ever-increasing suffering".

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At the time, her parents posted: It's now three weeks to the day that we learnt that Esme's story will not have the happy ending we've all prayed for, three long weeks in which we've had to contemplate the unthinkable and bear witness to Esme's ever-increasing suffering.

In the first couple of weeks one of the biggest difficulties was accepting that the team's goal was no longer to cure but just to manage pain.

This sounds obvious but you suddenly find yourself inexplicably sad that the nurses are no longer asking you for Esme's heart rate or temperature every few hours.

At one point I even found myself crying when I bumped into another child being wheeled to theatre and realised Esme will never have another general anaesthetic.

Instead, getting ahead of Esme's pain has become a full-time occupation for us and the team, and Ezzie is now on an ever-escalating daily mix of paracetamol, topical morphine, oxycodone, ketamine and, most recently, methadone.

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The psychology team here warn against reading adult meanings into our children's innocent words but it's difficult not to tear up when Esme tells us repeatedly I don't think my bottom's ever gonna get better, it's the hurtiest bottom in the whole world ....or My arm/leg/back/headache is killing me.

They also described how Esme had been bedridden for three months and would never walk again.

But the tot had her own Christmas tree and was even taken out of the Royal Marsden Hospital over the festive period to see Christmas lights in Morden before a screening of Frozen 2 at Everyman Esher.

SIGNS OF LEUKAEMIA EVERY PARENT NEEDS TO KNOW

LEUKAEMIA is a type of blood cancer, some forms of which are more common in children.

There are no specific signs or symptoms which would allow for a doctor to make a diagnosis without lab tests.

In all types of leukaemia symptoms are more commonly caused by a lack of normal blood cells than by the presence of abnormal white cells.

As the bone marrow becomes full of leukaemia cells, it is unable to produce the large numbers of normal blood cells which the body needs.

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Now Will and Rebecca, of West Norwood, south London, hope to donate money in Esmes name.

They have already raised 425,000 on GoFundMe.

Rebecca said in November: When we began fundraising we were punchy with our target to ensure we had enough for a self-funded transplant and said that whatever remained would go to the CCLG, the UK's leading kids cancer charity.

Given how desperately poor the funding is into paediatric AML research, we feel even more strongly about this now.

So a large chunk of the cash we have remaining (after spending some on novel drugs and supportive care) will be donated to AML research to try and spare future families the pain and anguish we have experienced.

To donate in memory of Esme, visit her GoFundMe page here.

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Girl, 3, dies in her parents arms on New Years Day after leukaemia battle - The Sun

International peace prize awarded to FNI executive director | Saginaw – Browncitybanner

By ohtadmin | on January 01, 2020

SAGINAW Gary L. Dunbar, PhD, executive director of the Field Neurosciences Institute (FNI), part of Ascension St. Marys, was recently presented with the Gusi Peace Prize International Award. Dr. Dunbar traveled to Manila, Philippines to accept this honor at the Gusi Peace Prize International 20th Annual Awards Night.

The Gusi Peace Prize award is given by the Gusi Peace Prize Foundation to recognize individuals and organizations who contribute to global peace and progress through a wide variety of fields. Dr. Dunbar was one of 18 international recipients selected for the award and chosen because of his global contributions in both the educational and the research domains of neuroscience. Similarly, his outstanding contributions in research, especially for developing new strategies for treating damage to the nervous system, including transplantation of genetically altered adult stem cells as a potential therapy for injury to the brain and spinal cord as well as neurological deficits in Huntingtons, Parkinsons and Alzheimers diseases, has earned international recognition and a prominent leadership role in the American Society for Neural Therapy and Repair.

I felt both honored and humbled to be selected for the Gusi Peace Prize, especially after meeting and hearing, first-hand, what the other 2019 Gusi Laureates have accomplished in the context of helping others, which was humbling to me, said Dr. Dunbar. The prize is given to those whose efforts have provided significant improvements to the lives of others through education, research, politics, and/or the arts, along with a strong commitment to humanitarian commitments, so I felt deeply honored to be included in this group of people.

Dr. Dunbar has been the executive director for FNI since 2008.

The Gusi Peace Prize was founded by the Honorable Ambassador Barry Gusi, to honor and continue the work of his late father, Captain Gemeniano Javier Gusi, who fought against Japanese oppression during World War II and later championed human rights in the Philippines. For 20 years, the Gusi Peace Prize Award has been awarded to prominent individuals from all over the world who have made significant contributions to the betterment of humankind.

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International peace prize awarded to FNI executive director | Saginaw - Browncitybanner

Red Shamrock: Fight never over, even when kids beat cancer – Iowa City Press-Citizen

Dick Hakes, Taking Liberties Published 10:13 a.m. CT Jan. 2, 2020 | Updated 11:21 a.m. CT Jan. 2, 2020

Finn is shown with his father, John Hall, during the nearly 18-month period about ten years ago in which the boy battled cancer through chemotherapy, radiation and immunotherapy.(Photo: Special to the Press-Citizen)

John Hall of Iowa City recalls how it all started in early 2009.

Before his son Finns third birthday, the boy started spiking fevers. Then he complained of stiff legs. Then a black eye showed up that would not go away.

A CT scan eventually produced what John said was the worst call I ever received.

A tumor on Finns cheek was traced to another on his adrenal gland. It was stage four neuroblastoma. He had about a 35% to 40% chance to survive it.

What followed was almost 18 months of aggressive treatment at University of Iowa Hospitals and Clinics (UIHC) chemotherapy sessions, two surgeries, two stem cell transplants, radiation and finally immunotherapy, which had just been green-lighted for broader use nationwide.

Those months became a heartbreakingly painful, sleepless, worrisome and all-encompassing ordeal for the entire family especially for Finn.

A recent photo of Finn Hall shows a smiling, cancer-free kid wearing a T-shirt promoting the Red Shamrock Foundation started by his father, John Hall.(Photo: Special to the Press-Citizen)

It worked, however, and the cancer disappeared.

We threw the cancer playbook at him, John said. I give the immunotherapy regiment credit for saving his life. It took care of the remaining cancer cells in the end. He was the first patient to complete that regiment at the U.

But it wasnt long after Finn came home and the family worked to return to a normal life that a new troubling reality emerged that led John to form the Red Shamrock Foundation.

Our only focus was getting past the cancer, he said. But now, because he had received so many harsh treatments at such a young age, we realized Finn would need some type of specialized care for the rest of his life.

Finn is 13 now and leading a pretty normal life, but because chemotherapy killed the seeds of his adult teeth, he still has all of his baby teeth, which will have to be replaced when he becomes an adult. He also has some minor hearing loss, kidney damage and must take growth hormones.

But it could have been a lot worse, John said. After cancer, kids sometimes have serious cognitive issues or chronic heart disease or secondary cancers due to the chemo and radiation. Some lose a limb or an organ.

He says he was amazed to learn that 95% of young cancer survivors can expect some type of serious chronic health condition by the time they reach age 45.

It hit me that people need to know about this, he said. I wanted to raise awareness that youre not done just because you have left the hospital.

John formed his nonprofit in 2011 with the help of friends who could handle obtaining legal status and help design a professional logo and web pages. A shamrock logo with a red heart seemed appropriate, given the familys Irish heritage.

The Red Shamrock Foundation mission is simple: Raise public awareness of the unique needs of kids who survive cancer, plus support survivorship programs and post-cancer research in Iowa.

As detailed on its website at http://www.redshamrock.org, the group sponsors three large fundraising events each year: A trail race at Regina High School in the spring, a golf outing in Mount Vernon in June and a Red Tie Gala during Childhood Cancer Awareness Month in September. Other money comes from donations and an online store operated through One Mission Fund Raising of Mount Vernon.

John Hall of Iowa City founded the Red Shamrock Foundation to raise public awareness that children who survive cancer will often face other medical challenges related to their treatment for the rest of their lives.(Photo: Dick Hakes/Special to the Press-Citizen)

As its director, John meets monthly with his board and often promotes the cause by speaking to civic groups. He says securing about $25,000 from the local 100 Men Who Careorganization a few years ago helped raise our profile in the community. All involved with Red Shamrock are unpaid volunteers.

In the past few years, the nonprofit has donated $110,000 for research projects at the university and through Passport for Care to assemble data on the health and needs of post-cancer patients.

Red Shamrock also provides educational materials for parents and teachers on how to explain cancer to kids and what to expect when a cancer survivor returns to class.

Finn was out of preschool for a year and a half, going through all he went through, then suddenly found himself back at preschool surrounded by 30 active, screaming kids, John said. The teachers were good, but Id drop him off and hed just sit in the middle of the room and cry. It took maybe six months for him to get comfortable again.

Dick Hakes(Photo: Special to the Press-Citizen)

The next step for Red Shamrock, John says, is to try to find a national partner and increase its scope beyond Iowa. A dedicated Team Red Shamrock group that participates in running events in other locations may be the catalyst for this, he said.

He has high praise for UIHC and points out that it now operates a survivorship clinic directed by Dr. Bill Terry, a pediatric oncologist.

The bottom line is to raise awareness of what pediatric cancer patients must face after theyve already fought the battle of their lives,John said. People need to understand that their fight is never over.

John is an Elkader native, a University of Iowa graduate in anthropology and a 30-year resident of Iowa City who works for Coldwell Banker in real estate. His wife Monica is a nurse at UIHC. Finn has an older brother, Sully.

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Conway supports man fighting rare double diagnosis of MS, ALS – THV11.com KTHV

CONWAY, Ark. A Conway man has spent many years living with Multiple Sclerosis, but this year he was also diagnosed with ALS, or Lou Gherigs Disease.

For the Nobles family, every day with their father, Greg, is a treasured moment.

"I was first diagnosed 16 years ago with MS," said Greg Nobles.

Life has been a challenge since, but it was this January when his health began to decline severely.

Greg lost all mobility. After getting treated for his symptoms and not seeing a difference is when neurologists confirmed Greg also suffers from ALS, a nervous system disease weakening muscles with no cure.

"Doctors have never seen a patient with both before, said Bailey Smith, Gregs daughter. Being diagnosed MS first, we got 15 good years with him versus the ALS now.

RELATED: A final fundraiser for the man who boosted the ice bucket challenge

Once active and known as one of the best hairstylist in town, Gregs now homebound hoping for relief from the pain he endures.

"My husband passed away from ALS in 2004, so I know the journey they are going on, said Diana Kirkland, a hair client of Gregs.

Kirkland knew she needed to do something for the Nobles.

She owns Legacy Acres in Conway.

This week shes preparing her space for a fundraising event Friday night to raise money so Greg can receive stem cell therapy, an expensive procedure done in Mexico, but one that will reduce his discomfort.

"If I could just get some mobility back, it's worth it, said Greg.

Greg has already received two rounds of stem cell therapy.

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Fortunately, hes starting to notice relief in his left leg.

But with ALS, hes given 3 to 5 years to live, but with a community coming together to help, his family hopes that love and support will give them more time with him.

"It means everything to us, said Smith. To continue to get stem cells for us, my babies to see my dad keep fighting.

Greg Nobles Fundraising Dinner is at Legacy Acres, 100 Legacy Acres Drive, in Conway on Friday night beginning at 6 p.m.

Everyone is invited. The event will have live music, a silent auction, catered food provided by Catering By S and I.

There will also be a donation table set up for a stem cell therapy fund.

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Conway supports man fighting rare double diagnosis of MS, ALS - THV11.com KTHV

None of these four beaming children would be alive today if a stranger had not given blood – The Sun

HERE are four beaming children none of whom would be alive today if a stranger had not given blood.

Each of their lives was saved by a transfusion, yet many of us never find the time to sign up to become a donor.

NHS Blood and Transplant is encouraging readers to make giving blood one of their New Year resolutions.

It is particularly calling on men to donate because their blood can be more suitable for treating patients. The families of these four survivors tell Lynsey Hope their stories.

'We worry every day he might suffer a serious bleed'

GEORGE CLAXTON lives with mum Faye, 36, a salon owner, dad Luke, 34, an electrical engineer, and sister Ella, six, in Huntingdon, Cambridgeshire. Faye says:

"When George was 14 months old he was diagnosed with a rare platelet disorder.

"The condition doesnt have a name but it means his blood cant clot properly.

"Tiny blood cells called platelets in his blood are the wrong shape and size and he has to take medication daily.

"We found out he had it after he suffered a virus and came out with a rash.

"Its called petechiae but can look similar to meningitis.

"We took George to A&E at Hinchingbrooke Hospital near Huntington. Blood tests came back negative and we were sent home.

"But two weeks later, we were back again.

"We were referred to specialists at Addenbrookes Hospital in Cambridge, who discovered George was bleeding under the skin.

"Its been hard to accept its a lifelong condition and not something that can be cured.

"There have been two occasions when George has needed a transfusion.

"The first was in June 2016.

"Doctors had to perform a transfusion before he had a tooth extracted to make sure he didnt bleed too much during the procedure.

"In May last year, he fell over in the school playground and hurt his elbow, causing a bleed in his joint.

"George has been brave from the start.

"He loves football but we worry every day he may have an accident that causes a serious bleed.

"He can also have spontaneous bleeds.

"His little sister was also diagnosed with the condition.

"She hasnt needed a transfusion yet but she may do and that is devastating for us as parents.

"Were so grateful to people who donate blood.

"It can enable people to live."

'Just an hour of your time could be the gift of a lifetime'

JESSICA FAY lives in Burnley with her mum Laura Bell, 32, dad Adam Fay, 39, who is a carer, and her brothers Kyle, 14, Denver, 13, Jayden, eight and Taylor, six. Laura, a full-time mum, says:

"Jessica was diagnosed with meningitis and septicaemia when she was 15 weeks old.

"I took her to the GP when she started feeling unwell.

"She wasnt feeding and had a high temperature.

"The doctor was concerned and said I must take her straight to hospital.

"Within hours of arriving at A&E, Jessica stopped breathing and was put on life-support.

"The disease had taken over her body and, one by one, her organs were shutting down.

"There was only one option. A blood transfusion might dilute the infection in her blood and give her a chance.

"There was a risk her body would reject the blood and we knew if that happened wed lose her.

"Incredibly though, that blood transfusion saved her life.

"She remained in intensive care for a week and, after three weeks, she came home.

"Jessica was being given so many treatments in those terrible few weeks that I didnt think too much about where the blood had come from.

"But when she recovered, I realised that without it she would not have made it. Unfortunately, Jessica suffered some brain damage because of what happened.

"She has social communication disorder and finds it hard to make friends.

"She is an incredible child and Im so grateful to whoever it was that took the time to donate blood for her.

"If someone hadnt donated that blood, Jessica would be dead.

"She has done all she can to give something back.

"Shes raised thousands of pounds for charity by organising events in the community.

"I would urge anyone who can to give blood it is just an hour of your time but it could be the gift of a lifetime to a child like Jessica.'

'Our baby can be in a lot of pain due to the disease'

EZRAH PINK was born with sickle cell disease. He lives with his mum Serena, 30, who looks after an office building, and her partner Courtney, 32, an estate agent, in Beckenham, Kent. Serena says:

"We knew before Ezrah was born that he might have sickle cell disease.

"When I was pregnant, doctors found out I carried a gene.

"About a week after he was born, they confirmed Ezrah had the disease.

"People with sickle cell produce unusual C-shaped red blood cells, meaning they sometimes get stuck or block blood vessels. At first, he didnt show any symptoms.

"He started having problems when he was around 11 months.

"Since then its been a whirlwind. We have been in and out of hospital.

"Id never known anyone with sickle cell so its been a tough learning curve and the condition will affect him for life.

"Ezrah has already had four blood transfusions.

"When one of his odd-shaped blood cells gets stuck, it causes what is called a sickle cell crisis and this can cause a great deal of pain.

"Ezrah is also prone to serious infections.

"He takes penicillin every day as well as folic acid to boost his immunity.

"Id never given blood before having Ezrah.

"It wasnt until the first time doctors told me that they were going to have to transfuse him that I realised how important it was.

"Im pregnant now so I cant do it myself just yet, but as soon as I can sign up, I will.

"You never know whats round the corner.

"Its not until it happens to someone close to you that you realise how important it is."

'While recovering he's had more than 50 transfusions'

JACOB JESSEL lives with mum Emma Riley, 47, an NHS project manager, dad Nick Jessel, 44, a sales manager, and brother Sam, eight, near Grimsby, Lincs. Emma says:

"Jacob was diagnosed with a rare blood disorder when he was seven.

"We went on a camping trip and he was bitten by a mosquito. A huge bruise came out, which covered most of his forearm.

"Our GP took blood and told us his blood count was dangerously low and that we had to take him straight to hospital.

"It was a huge shock and it was obvious to us that doctors feared he had leukaemia.

"Jacob was given an emergency bone marrow biopsy at Sheffield Childrens Hospital and we were told he probably had cancer.

"Waiting for the results of the biopsy was horrible.

"We were relieved when the tests came back negative, but more tests revealed he had an incurable bone marrow disorder.

"Doctors said hed need a transplant, which he had in 2017.

"There was only one match on the register at the time so we went ahead with it. But sadly that didnt work.

"About a month later, he had a transplant using his dads stem cells, which has been effective.

"While recovering, he had more than 50 blood transfusions.

"He now attends a follow-up clinic every four to six months to make sure his blood keeps working properly.

"Before Jacob was ill, I was one of these people who never got round to giving blood.

"I thought it was a good thing to do but I kept putting it off.

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"But every time a unit of blood was delivered to the ward for Jacob, I felt incredibly relieved that someone, somewhere, had taken the time to give blood.

"Now I give blood regularly. Its a good feeling to know you are helping someone else.

"I know how grateful the recipient will 7 be. Its the best gift anyone can give."

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None of these four beaming children would be alive today if a stranger had not given blood - The Sun

Predicting shifts in technology and science can be tricky, but here’s what could happen in 2020 – inews

NewsScienceIt's likely to be an eventful year for gene editing and stem cell research

Tuesday, 31st December 2019, 7:03 am

Gene editing

It was suggested that prime editing has the potential to mend about 89 per cent of the 75,000 harmful genetic mutations that lie behind hereditary diseases, such as cystic fibrosis and the blood disorder sickle cell disease.

3D rockets

Major strides were made in rocket science last year, with a number of 3D-printed engine prototypes being successfully tested.

This year, Relativity Space, a California startup, hopes to go one better. It plans to become the first company in the world to print almost an entire rocket 95 per cent of it which it hopes will be ready for launching at the end of the year.

Only a handful of components, such as electronics and circuit boards, will have to be made by hand for the craft, named Teran 1.

If successful, the launch will pave the way for numerous 3D-printed rockets to be sent into space much more quickly and cheaply than they are at the moment.

Stem cells

Scientists are working around the world on trials of promising stem-cell treatments for blindness, spinal cord injury, heart failure, diabetes, Parkinsons disease and lung cancer, and some of the first results should become available later in the year.

Embryonic, or pluripotent, stem cells have extraordinary medical potential because they can develop into any of the 220 or so mature, specialised cells of the body, from insulin-making pancreatic cells to the nerve cells of the brain.

Mars

The 2020 mission of the ExoMars programme, if all goes to plan, will deliver a European rover and a Russian platform to the surface of Mars.

ExoMars will be the first mission to combine the capability to move across the surface of the planet and to the ability study Mars at depth. Meanwhile, Nasa will launch a separate mission to study the habitability of Mars and prepare for future human missions.

Smart needle

They have demonstrated that the technique works in the laboratory, and are in the early stages of a three-year clinical trial to test it in living people.

The researchers have focused on lymphoma so far, but said that they are hopeful the technique could also be used further down the line to diagnose other forms of the disease, such as breast and prostate cancer.

At the moment, diagnosing lymphoma can be an invasive process that involves a surgical biopsy followed by a nerve-racking wait for the result, which can often take two weeks or more.

The smart needle uses light to pinpoint cancerous tissues almost instantaneously.

Using a technique called Raman spectroscopy, the optical biopsy measures the light scattered by tissues when a laser contained in the needle is shone on it.

The light scatters differently from healthy tissues than it does from diseased tissues, meaning that doctors can make their diagnosis straight away.

Japan's robotic Olympics

Japan has pledged to make the 2020 Tokyo Olympics and Paralympics the most innovative in history by deploying robots to assist spectators and staff during the games.

The Human Support Robot (HSR) and Delivery Support Robot (DSR), developed by Toyota, will be used in tandem.

HSR, a one-armed robot about 3ft (1m) tall, can hold objects, pick things up off the ground and reach up high. It can move by itself, or can be controlled remotely as it attends to people in wheelchairs, guiding them to their seats and helping to carry items.

When people order food or drinks using a tablet computer, DSR will transport the items in a basket and HSR will then deliver them directly to guests.

Waste to Energy

The worlds largest waste-to-energy plant is set to open on the outskirts of Shenzhen, China. The new plant is made to handle 5000 tons of waste per day, burning the waste to generate electricity.

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Predicting shifts in technology and science can be tricky, but here's what could happen in 2020 - inews

On the Road: A year to remember – WCBI

On the Road with Steve Hartman: A Year to Remember will air on CBSN on January 1 at 8 p.m., 11 p.m. and 2 a.m. ET. Its also available on the free CBS News app. And dont missOn the Road for the holidays with Steve Hartman.

Every week, Steve Hartman travels America, talking to regular people and looking for the extraordinary in the ordinary. Theyre from all walks of life, but all are inspiring. Its amazing the impact kids have, especially.

11-year-old expands her charity granting wishes

At a nursing home in northwest, Arkansas, theres a gem named Ruby. As CBS News first reported in March, 11-year-old Ruby Chitsey likes to go to work with her mom, Amanda, a nurse who travels to several nursing homes in the area. It was on one of those visits that Ruby started going up to residents with her notepad and asking, If you could have any three things, what would they be?

Ruby said she was mostly curious about what theyd say. Instead of asking for money or a fancy car, they asked for electric razors, new shoes, Vienna sausage and other basic items. So she started a charity calledThree Wishes for Rubys Residents. Now, while her mom is caring for patients, Ruby goes room to room, jots down wishes and sets out to grant them.

Since first sharing her story, Ruby has helped start chapters of her charity in other states. She speaks to advocates for the aging, and of course, she is still very much hands-on.

Texas school bus driver gives more than just a ride

Bus driver Curtis Jenkins loves delivering little ones to Lake Highlands Elementary in Dallas, Texas. To show his love and understanding, Curtis gives presents throughout the year and each one is personally selected with that child in mind.

Over the year he has bought these kids bikes, backpacks, handed out cards on birthdays and even turkeys at Thanksgiving. He has spent thousands out of his own pocket. And yet, if you ask the kids what they like most about Curtis, the gifts dont even come up.

He really cares about us, one child said.

Since that story first aired in May, Curtis has gotten a big promotion. He still sees the kids all the time, but hes no longer a bus driver. Instead, hes been granted the title of Relationship Consultant, teaching staff all across the district how they can form bonds with students like he did.

Toddler contributes to making a sign language town

At the far end of Islington Road in Newton, Massachusetts, lives a little girl near and dear to the neighborhood. Samantha Savitz, 2, is deaf, but boy does she love to talk to anyone who knows sign language. If someone cant, that makes her just a little sad.

Her desire for engagement has been painfully obvious to everyone in the neighborhood. Whenever they see her on a walk or in her yard, they find themselves at a frustrating loss for words. So on their own, Sams neighbors got together, hired an instructor and are now fully immersed in an American Sign Language class.

Sometimes it feels like America is losing its sense of community. But then you hear about a place like this, where the village it takes to raise a child is alive and well and here to remind us that what makes a good neighborhood is nothing more than good neighbors. Since Steve visited Newton in February, Sam celebrated her 3rd birthday, and the class size has doubled to 40 students.

Middle school teacher takes in student battling kidney disease

Good educators can make all the difference. At AXL Academy in Aurora, Colorado, middle school math teacher Finn Lanning has gone above and beyond for one student, 13-year-old Damien.

One day, Damien told Finn he wasnt coming back to school. He learned Damien was in foster care, had kidney disease and because social services couldnt find a foster family willing and able to meet his medical needs, Damien had to leave school and move into a hospital. He also needed a transplant, desperately. A lot of times, you cant get a transplant if you dont have a stable home to return to after surgery.

Thats how Finn became a foster parent. He took in Damien, dialysis needs and all, even though prior to that, hed been a confirmed bachelor who delighted in his childlessness. But he decided to adopt Damien.

Because of Finn, Damien got back on the transplant list and got his new kidney. Today, his kidney is doing well and the adoption is almost complete.

97-year-old veteran still hard at work bagging groceries

When you reach a certain age, just getting down to the driveway can feel like a full days work. But for 97-year-old Benny Ficeto of Perth Amboy, New Jersey, overcoming those stairs is just the beginning of his workday. Two days a week, he clocks in for a 4-hour shift as a bag boy at the local Stop & Shop.

Benny used to be warehouse supervisor for a cosmetics company. He supposedly retired back in the 80s, but hes been doing odd jobs ever since because he said he loves a hard days work and always has.

Benny served in the Army Air Force during World War II. He was a gunner on a B-25 Mitchell bomber, flying mostly over northern Africa and Italy. He still approaches his job with that same tireless, warrior-like determination. For example, Benny said hed sooner stack a honeydew on white bread than loaf around on the job.

For Benny, his reason to continue working is to go out and earn, not just a paycheck, but a purpose. And avoid breaks, at all costs.

Cleveland auto mechanic fulfills lifelong dream to become a doctor

If youre having trouble motivating to go back to work or school after the holidays, 48-year-old Carl Allamby might help you with that. He dreamed about becoming a doctor but said growing up, that wasnt always realistic.

We were on welfare. I remember the powdered milk, the government powdered milk, he said.

Because they were so poor, young Carl quickly set aside his professional aspirations and focused instead on becoming the best auto mechanic he could be. Eventually he got his own shop and for 15 years, he did OK. Until one day, he decided to step it up a notch.

In 2006, Carl enrolled at Ursuline College. His intention was to get a business degree to help him manage his repair shop. But there was one hurdle: a biology class. He couldnt understand why he had to take it and he put it off as long as possible.

Im a business major, what do I care about biology. And in the first hour of being there, I knew what I wanted to do with the rest of my life. All those ideas of wanting to be a doctor just came rushing back, Carl said.

Now the car doctor is now a doctor-doctor. Last spring, he graduated from Northeast Ohio Medical University and today hes an emergency medical resident at Cleveland Clinic Akron General.

Once housebound, young boy gets his chance to see the world

Aside from immediate family, no one was allowed in the house to see 3-year-old Quinn Waters of Weymouth, Massachusetts. More importantly, Quinn wasnt allowed out. Parents Jarlath and Tara Waters say Quinns natural immunity was temporarily wiped out after he got a stem cell transplant to treat his brain cancer.

Fortunately, the kid is a fighter, and as we first reported a few months ago, he kept a mostly positive attitude. But it still stunk. There would be days when Quinn was literally pounding to get out.

Unfortunately, staring out a window is a poor substitute for walking out the door. Quinns connection to the outside world has been limited to whoever passes by, which hasnt been all that limiting, actually. The neighbors started showing up to entertain Quinn, the police caught wind of it and pretty soon topnotch performers were just showing up on Quinns front lawn.

One minute it could be a dog parade, the next, a team of Irish step dancers. Everyone brought together by word of mouth and a will to help Quinn get better. Which his parents said, did start happening.

Its the positive energy from all these people that we believe has gotten him through his sickness, you know. You can never repay, you know, just maybe pay it forward, Jarlath said.

After this story first aired in August, things got even better for Quinn. By Halloween, doctors had released him from home confinement and free to be a kid again, he rushed outdoors at warp speed. He also got to drop the puck at a Boston Bruins game, feel the sand between his toes at the Massachusetts shore, and even watch the Macys Thanksgiving Day Parade pass by.

To contact On the Road, or to send us a story idea, email us: OnTheRoad@cbsnews.com.

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On the Road: A year to remember - WCBI

2019: the year gene therapy came of age – Breitbart

Washington (AFP) In the summer, a mother in Nashville with a seemingly incurable genetic disorder finally found an end to her suffering by editing her genome.

Victoria Grays recovery from sickle cell disease, which had caused her painful seizures, came in a year of breakthroughs in one of the hottest areas of medical research gene therapy.

I have hoped for a cure since I was about 11, the 34-year-old told AFP in an email.

Since I received the new cells, I have been able to enjoy more time with my family without worrying about pain or an out-of-the-blue emergency.

Over several weeks, Grays blood was drawn so doctors could get to the cause of her illness stem cells from her bone marrow that were making deformed red blood cells.

The stem cells were sent to a Scottish laboratory, where their DNA was modified using Crispr/Cas9 pronounced Crisper a new tool informally known as molecular scissors.

The genetically edited cells were transfused back into Grays veins and bone marrow. A month later, she was producing normal blood cells.

Medics warn that caution is necessary but, theoretically, she has been cured.

This is one patient. This is early results. We need to see how it works out in other patients, said her doctor, Haydar Frangoul, at the Sarah Cannon Research Institute in Nashville.

But these results are really exciting.

In Germany, a 19-year-old woman was treated with a similar method for a different blood disease, beta thalassemia. She had previously needed 16 blood transfusions per year.

Nine months later, she is completely free of that burden.

For decades, the DNA of living organisms such as corn and salmon has been modified.

But Crispr, invented in 2012, made gene editing more widely accessible. It is much simpler than preceding technology, cheaper and easy to use in small labs.

The technique has given new impetus to the perennial debate over the wisdom of humanity manipulating life itself.

Its all developing very quickly, said French geneticist Emmanuelle Charpentier, one of Crisprs inventors and the cofounder of Crispr Therapeutics, the biotech company conducting the clinical trials involving Gray and the German patient.

Cures

Crispr is the latest breakthrough in a year of great strides in gene therapy, a medical adventure started three decades ago, when the first TV telethons were raising money for children with muscular dystrophy.

Scientists practising the technique insert a normal gene into cells containing a defective gene.

It does the work the original could not such as making normal red blood cells, in Victorias case, or making tumor-killing super white blood cells for a cancer patient.

Crispr goes even further: instead of adding a gene, the tool edits the genome itself.

After decades of research and clinical trials on a genetic fix to genetic disorders, 2019 saw a historic milestone: approval to bring to market the first gene therapies for a neuromuscular disease in the US and a blood disease in the European Union.

They join several other gene therapies bringing the total to eight approved in recent years to treat certain cancers and an inherited blindness.

Serge Braun, the scientific director of the French Muscular Dystrophy Association, sees 2019 as a turning point that will lead to a medical revolution.

Twenty-five, 30 years, thats the time it had to take, he told AFP from Paris.

It took a generation for gene therapy to become a reality. Now, its only going to go faster.

Just outside Washington, at the National Institutes of Health (NIH), researchers are also celebrating a breakthrough period.

We have hit an inflection point, said Carrie Wolinetz, NIHs associate director for science policy.

These therapies are exorbitantly expensive, however, costing up to $2 million meaning patients face grueling negotiations with their insurance companies.

They also involve a complex regimen of procedures that are only available in wealthy countries.

Gray spent months in hospital getting blood drawn, undergoing chemotherapy, having edited stem cells reintroduced via transfusion and fighting a general infection.

You cannot do this in a community hospital close to home, said her doctor.

However, the number of approved gene therapies will increase to about 40 by 2022, according to MIT researchers.

They will mostly target cancers and diseases that affect muscles, the eyes and the nervous system.

Bioterrorism

Another problem with Crispr is that its relative simplicity has triggered the imaginations of rogue practitioners who dont necessarily share the medical ethics of Western medicine.

Last year in China, scientist He Jiankui triggered an international scandal and his excommunication from the scientific community when he used Crispr to createwhat he called thefirst gene-edited humans.

The biophysicist said he had altered the DNA of human embryos that became twin girls Lulu and Nana.

His goal was to create a mutation that would prevent the girls from contracting HIV, even though there was no specific reason to put them through the process.

That technology is not safe, said Kiran Musunuru, a genetics professor at the University of Pennsylvania, explaining that the Crispr scissors often cut next to the targeted gene, causing unexpected mutations.

Its very easy to do if you dont care about the consequences, Musunuru added.

Despite the ethical pitfalls, restraint seems mainly to have prevailed so far.

The community is keeping a close eye on Russia, where biologist Denis Rebrikov has said he wants to use Crispr to help deaf parents have children without the disability.

There is also the temptation to genetically edit entire animal species malaria-causing mosquitoes in Burkina Faso or mice hosting ticks that carry Lyme disease in the US.

The researchers in charge of those projects are advancing carefully, however, fully aware of the unpredictability of chain reactions on the ecosystem.

Charpentier doesnt believe in the more dystopian scenarios predicted for gene therapy, including American biohackers injecting themselves with Crispr technology bought online.

Not everyone is a biologist or scientist, she said.

And the possibility of military hijacking to create soldier-killing viruses or bacteria that would ravage enemies crops?

Charpentier thinks that technology generally tends to be used for the better.

Im a bacteriologist weve been talking about bioterrorism for years, she said.Nothing has ever happened.

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2019: the year gene therapy came of age - Breitbart

The health stories we won’t forget and what 2020 holds – nation.co.ke

Which stories made the headlines and why?By EUNICE OMOLLOMore by this AuthorBy NASIBO KABALE More by this Author2daysago

It has been a year marked by milestones from new vaccines for deadly diseases to a law that meant life for recipients of organs. But, along the way there were hitches that threatened crucial programmes.

In September, Kenya became the third African country to start the routine immunisation of children against malaria using the worlds first vaccine. Kenya was picked by the World Health Organisation (WHO) for the malaria drive to vaccinate 360,000 children per year. The drive has already taken place in eight counties in Western Kenya and all endemic counties in a pilot that will end in 2021.

Mosquirix, the brand name for RTS, S vaccine, triggers the immune system to defend itself against the first stages of the disease shortly after a malaria parasite enters the bloodstream through a mosquito bite.

Children in the eight counties will receive four doses of RTS, S at six, seven, nine and 24 months in addition to standard vaccines.

Kenya also became the 16th African country to introduce the cervical cancer vaccine. The Human Papillomavirus (HPV) vaccine works by preparing the body to fight the germs that cause the infections.

The vaccination rollout in Kenya targets 766,207 girls aged 10 and will cost the government Sh467 per dose for the same vaccine that costs more than Sh10,000 in high-income countries.

The vaccine is most effective when given to girls before they are sexually active and could be exposed to the virus.

Two doses of the vaccine are given to the girls six months apart at about 9,000 public, private and faith-based centres countrywide.

Signed into law in June and published in July, the 2017 Health Act operationalises and ensures important constitutional provisions for health services. Before its enactment, organ transplant donation procedures were not clear. With the law in place, patients have hope as it now allows people to donate their organs to others or for research when they die.

The law also gives weight to some of the more aspirational health language in the Constitution. It seeks to safeguard access to healthcare services for vulnerable groups by making clear the governments obligation to provide these for women, the elderly, the disabled, children, youth and members of minority or marginalised communities.

The Act also instructs the national government to expand free maternity care and childhood immunisation by mandating funding for these services through ring-fenced, conditional grants grants earmarked for a specific activity and must meet certain conditions. Employers and all formal workplaces will also be required to provide breastfeeding facilities to promote the well-being of infants, and health facilities must provide emergency care or face punitive measures.

For the second time since 1994, renowned population and development scholars, scientists and researchers met in Nairobi in November for the International Conference on Population and Development (ICPD). The 179 governments present at the Nairobi meet reaffirmed their commitment to the goals they set in Cairo 25 years ago to end the unmet need of child spacing, to end preventable maternal deaths, to end sexual and gender-based violence and to end early marriages and other harmful practices against women and girls.

Countries agreed to bring down to zero cases of maternal and infant deaths, and gender-based violence by 2030.

For instance, as a way of reducing unsafe abortions, Kenya is expected to reinstate post-abortion care guidelines which had been revoked.

The aims of the ICPD are rooted in the sacred value and dignity of every human life.

President Uhuru Kenyatta directed the Health ministry to establish a task force to assess the status of mental health in the country.

The team is expected to come up with new policies to address growing concerns about mental health among Kenyans.

The teams findings will help the government in allocation of resources to mental health.

The task force is expected to assess the mental health systems including the legal, policy and administrative environment to identify areas that may benefit from reform for optimal delivery.

In addition, the team will consider the changing societal dynamics and associated threats to mental well-being such as substance abuse, gambling, sexual and gender-based violence, cyber bullying, child abuse and neglect.

Health Cabinet Secretary Sicily Kariuki said the implementation of the national mental health policy will create a sustainable response mechanism, including resource mobilisation, training and creation of awareness.

Four counties have this year taken part in the Universal Health Coverage (UHC) pilot which kicked off in December last year.

Residents of Isiolo, Machakos, Kisumu and Nyeri have been receiving next to free medical services as part of the programme ahead of the nationwide roll-out.

About 80 per cent of the money for the pilot has gone into the purchase of drugs and basic medical equipment, the Health ministry said, with additional Sh800 million allocated to each of the regions for complicated cases that would be referred outside the participating counties.

The pilot has had its fair share of troubles especially in Kisumu where doctors have been on strike for the three months. Counties have also had to grapple with drug shortage.

The ministrys approach to achieving UHC has been through removal of user fees at all public hospitals, including level four and five facilities and ensuring commodity security through the Kenya Medical Supplies Authority (Kemsa). Kemsa, however, has been unable to deliver 100 per cent of the required drugs.

The hospitals have also experienced a surge in numbers where the county data shows a 300 per cent increase, which could mean trust in the facilities or easier access to healthcare given the low costs.

A deal that would see 100 Cuban doctors come to Kenya was sealed in 2018. Under the agreement, 47 would work as specialists and 53 family physicians would be deployed to the counties.

At the same time, Kenya secured space for its 50 doctors to study in Cuba, famed for its world-class healthcare system.

The programme was meant to instill much-needed skills in the ailing sector.

However, this year, the suicide of a Kenyan doctor who was sponsored by the government to study family medicine in Cuba exposed the programmes soft underbelly. Kenya Medical Practitioners, Pharmacists and Dentists Union Nairobi Secretary-General, Dr Thuranira Kaugiria, said the doctors who travelled to Cuba were given a raw deal and had on several occasions unsuccessfully sought to air their grievances with the ministry.

Here in the country, two Cuban doctors were kidnapped in Mandera County which led the ministry to reassign 10 medics stationed in border counties to Kenyatta National Hospital, National Spinal Injury Hospital, Mathare Mental Hospital and Kiambu County hospitals.

For the 37 million people who have HIV around the world, the news of a possible cure for the disease was more than welcome.

A London patient with HIV became the second person ever to be free of the virus after a bone marrow transplant, raising hopes of a cure. In 2007, another patient identified as the Berlin patient received a bone-marrow transplant from a donor with natural immunity to the virus.

Timothy Brown, the so-called Berlin patient, who later went public, and the London patient, who does not want to disclose his identity, received stem cells from a donor with a rare genetic mutation of the CCR5 gene, making them HIV-resistant. Brown has been virus-free ever since. The London patient stopped taking the medication 18 months ago and there is no sign of a return of HIV.

The procedure in itself can never be offered as a cure for HIV infection because stem cell transplants carry risks.

An expos by NTV investigative team revealed how supermarkets are using toxic chemicals to make their meat look fresher for longer.

The expos, which involved laboratory tests on meat samples which revealed that supermarkets use chemical as a food preservative to keep the food fresh for longer.

The documentary highlighted how rotten the system is. The fact that more than one supermarket was doing it means that it is an open secret which led the Ministry of Health to conduct a random survey on the safety of meat sold in the capital city.

The survey exposed just rotten the system is the results showing that six out of 40 samples collected tested positive to the preservative Sodium Metabisulfite which is harmful in large doses.

All the meat in the affected outlets were destroyed and some outlets were closed.

The year was characterised by adverse weather conditions, with drought being experienced at the start of the year and heavy rainfall at the end.

Just before the start of the short rain in October, between August and October, at least 3.1 million people were projected to be facing acute food insecurity.

The most hit areas were Turkana, Marsabit, Mandera, Wajir, Garissa, Tana River and Baringo counties, according to the Integrated Food Security Phase Classification report.Then came the floods caused by the October-November-December rainfall.

As of December 2019, at least 130 people had been reported dead from the flooding and landslides and more than 17,000 displaced.

Earlier in December, the government announced it had set aside Sh6.1 billion to restore infrastructure damaged by floods.

Blood test for breast cancer

Recent findings by scientists from University of Nottingham in England that a blood test could potentially detect breast cancer at least five years before other symptoms and lumps appear, could just be the answer to the killer disease that claims lives in millions globally.

A more elaborate research on the blood test is set to kick off in 2020. According to the scientists, if all goes well, the test could be in the market within the next five years.

According to the Kenya Medical Research Institute cancer registry, eight out of 10 cancers in the country are detected late due to low awareness of symptoms.

Breast cancer is the second most common type of cancer in the country, with women under 50 accounting for 50 per cent of cases.

The test, which would be much cheaper and easier to conduct than a mammogram, looks for autoantibodies which are produced by the body in reaction to the presence of cancer bodies in the blood. According to WHOs International Agency for Research on Cancer, the global cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million deaths in 2018. One in five men and one in six women worldwide develop cancer during their lifetime, and one in eight men and one in 11 women die from the disease.

These new figures highlight that much remains to be done to address the alarming rise in the cancer burden globally and that prevention has a key role to play, said International Agency for Research on Cancer Director Christopher Wild.

Kenyans countrywide will experience UHC in 2020. This is after a 12-month pilot programme that has been running in the four counties of Nyeri, Machakos, Isiolo and Kisumu. Speaking during the last meeting of the Council of Governors held early this month in Nairobi, chairman Wycliffe Oparanya hinted that counties are ready for the roll out.

But, the national government should find ways to solve the challenges that have been experienced in the four counties, he said.

Speaking to HealthyNation, Cabinet Secretary Sicily Kariuki had said her ministry was ready for the scale up and had outlined the challenges experienced. The lessons we have picked is that once we invest right, once we are consistent and speak to the population, the issue of confidence comes back within the shortest time possible, she said.

The Kenya-Cuba relationship is set to bring in an additional tactical move in the fight against malaria in 2020. The ministry is setting sights on the introduction of malaria bio larvicide method to combat transmission in endemic areas.

Larviciding refers to the regular application of chemical or microbial insecticides to water bodies or water containers to kill the aquatic immature forms of the mosquito (the larvae and pupae).

According to Ms Kariuki, the collaboration with the Cuban government would help Kenya learn how the country eradicated the disease.

In the first quarter of the coming year, we have identified the experts that we will require to bring in and train our own people in collaboration with the experts coming from Cuba.

It is good to note that there is no malaria in Cuba. They got to that stage by applying the technology, which we believe will play a big role in Kenya in the fight against Malaria, she said.

The aim of larviciding is to reduce the adult population of mosquitoes by killing the aquatic immature forms, so that fewer will develop into adults. This should reduce the number of mosquitoes that bite and infect humans with malaria.

Additional reporting by Bernadine Mutanu

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The health stories we won't forget and what 2020 holds - nation.co.ke

The Major Discoveries That Could Transform the World in the Next Decade – Livescience.com

The last decade ushered in some truly revolutionary advances in science, from the discovery of the Higgs boson to the use of CRISPR for Sci-Fi esque gene editing. But what are some of the biggest breakthroughs still to come? Live Science asked several experts in their field what discoveries, techniques and developments they're most excited to see emerge in the 2020s.

The universal flu shot, which has eluded scientists for decades, may be one truly groundbreaking medical advances that could show up in the next 10 years.

"It has sort of become a joke that a universal [flu] vaccine is perennially just five to 10 years away," said Dr. Amesh Adalja, an infectious-disease specialist and senior scholar at the Johns Hopkins Center for Health Security in Baltimore.

Related: 6 Flu Vaccine Myths

But now, it appears that this "may actually be true," Adalja told Live Science. "Various approaches to universal flu vaccines are in advanced development, and promising results are starting to accrue."

In theory, a universal flu vaccine would provide long-lasting protection against the flu, and would eliminate the need to get a flu shot each year.

Some parts of the flu virus are constantly changing, while others remain mostly unchanged from year to year. All of the approaches to a universal flu vaccine target parts of the virus that are less variable.

This year, the National Institute of Allergy and Infectious Diseases (NIAID) began its first-in-human trial of a universal flu vaccine. The immunization aims to induce an immune response against a less variable part of the flu virus known as the hemagglutinin (HA) "stem." This Phase 1 study will look at the safety of the experimental vaccine, as well as participants' immune responses to it. Researchers hope to report their initial results in early 2020.

Another universal-vaccine candidate, made by the Israeli company BiondVax, is currently in Phase 3 trials, which is an advanced stage of research that looks at whether the vaccine really is effective meaning that it protects against infection from any strain of flu. That vaccine candidate contains nine different proteins from various parts of the flu virus that vary little between flu strains, according to The Scientist. The study has already enrolled more than 12,000 people, and results are expected at the end of 2020, according to the company.

In the last decade, scientists have successfully grown mini-brains, known as "organoids," from human stem cells that differentiate into neurons and assemble into 3D structures. As of now, brain organoids can only be grown to resemble tiny pieces of a brain in early fetal development, according to Dr. Hongjun Song, a professor of neuroscience at the Perelman School of Medicine at the University of Pennsylvania. But that could change in the next 10 years.

"We could really model, not just cell type diversity, but the cellular architecture" of the brain, Dr. Song said. Mature neurons arrange themselves in layers, columns and intricate circuits in the brain. Currently, organoids only contain immature cells that cannot forage these complex connections, but Dr. Song said that he expects the field may overcome this challenge in the coming decade. With miniature models of the brain in hand, scientists could help deduce how neurodevelopmental disorders unfold; how neurodegenerative diseases break down brain tissue; and how different peoples' brains might react to different pharmacological treatments.

Someday (though perhaps not in 10 years), scientists may even be able to grow "functional units" of neural tissue to replace damaged areas of the brain. "What if you have a functional unit, pre-made, that you could click into the damaged brain?" Song said. Right now, the work is highly theoretical, but "I think in the next decade, we'll know" whether it could work, he added.

In this decade, rising sea levels and more extreme climate events revealed just how fragile our beautiful planet is. But what does the next decade hold?

"I think we will see a breakthrough when it comes to action on climate," said Michael Mann, a distinguished professor of meteorology at Penn State University. "But we need policies that will accelerate that transition, and we need politicians who will support those policies," he told Live Science.

In the next decade, "the transformation of energy and transportation systems to renewables will be well under way, and new approaches and technologies will have been developed that allow us to get there faster," said Donald Wuebbles, a professor of atmospheric sciences at the University of Illinois at Urbana-Champaign. And, "the increasing climate-related impacts from severe weather and perhaps from sea-level rise finally get enough people's attention that we really begin to take climate change seriously."

Good thing too, because based on recent evidence, there's a scarier, more speculative, possibility: Scientists might be underestimating the effects that climate change have had on this century and beyond, Wuebbles said."We should learn much more about that over the next decade."

Related: The Reality of Climate Change: 10 Myths Busted

In the last decade, the biggest news in the world of the very small was the discovery of the Higgs boson, the mysterious "God particle" that lends other particles their mass. The Higgs was considered the crowning jewel in the Standard Model, the reigning theory that describes the zoo of subatomic particles.

But with the Higgs discovered, many other less-famous particles began taking center stage.This decade, we have a reasonable shot at finding another of these elusive, as-yet-still hypothetical particles the axion, said physicist Frank Wilczek, a Nobel laureate at the Massachusetts Institute of Technology. (In 1978, Wilczek first proposed the axion). The axion is not necessarily a single particle, but rather a class of particles with properties that rarely interact with ordinary matter. Axions could explain a long-standing conundrum: Why the laws of physics seem to act the same on both matter particles and their antimatter partners, even when their spatial coordinates are flipped, as Live Science previously reported.

Related: Strange Quarks and Muons, Oh My! Nature's Tiniest Particles Dissected

And axions are one of the leading candidates for dark matter, the invisible matter that holds galaxies together.

"Finding the axion would be a very great achievement in fundamental physics, especially if it happens through the most likely path, i.e., by observing a cosmic axion background which provides the 'dark matter.'" Wilczek said. "There's a fair chance that could happen in the next five to 10 years, since ambitious experimental initiatives, which could get there, are blossoming around the world. To me, weighing both the importance of discovery and likelihood of it happening, that's the best bet."

Among those initiatives is the Axion Dark Matter Experiment (ADMX) and the CERN Axion Solar Telescope, two major instruments that are hunting for these elusive particles.

That said, there are other possibilities too we may yet detect gravitational waves, or ripples in spacetime, emanating from the earliest period in the universe, or other particles, known as weakly interacting massive particles, that could also explain dark matter, Wilczek said.

On Oct. 6, 1995, our universe got bigger, sort of, when a pair of astronomers announced the discovery of the first exoplanet to orbit a sun-like star. Called 51 Pegasi b, the orb showed a cozy orbit around its host star of just 4.2 Earth days and a mass about half that of Jupiter's. According to NASA, the discovery forever changed "the way we see the universe and our place in it." More than a decade later, astronomers have now confirmed 4,104 worlds orbiting stars outside of our solar system. That's a lot of worlds that were unknown just over a decade ago.

So, the sky's the limit for the next decade, right? According to Massachusetts Institute of Technology's Sara Seager, absolutely. "This decade will be big for astronomy and for exoplanet science with the anticipated launch of the James Webb Space Telescope [JWST]," said Seager, a planetary scientist and astrophysicist. The cosmic successor to the Hubble Space Telescope, JWST is scheduled to launch in 2021; for the first time, scientists will be able to "see" exoplanets in infrared, meaning they can spot even faint planets that orbit far off from their host star.

What's more, the telescope will open a new window into the characteristics of these alien worlds. "If the right planet exists, we will be able to detect water vapor on a small rocky planet. Water vapor is indicative of liquid water oceans since liquid water is needed for all life as we know it, this would be a very big deal," Seager told Live Science. "That's my number one hope for a breakthrough." (The ultimate goal, of course, is to find a world that has an atmosphere similar to that of Earth's, according to NASA; in other words, a planet with conditions capable of supporting life.)

And of course, there will be some growing pains, Seager noted. "With the JWST, and the extremely large ground-based telescopes anticipated to come online, the exoplanet community is struggling to transform from individual or small team efforts to large collaborations of dozens or over one hundred people. Not huge by other standards (e.g., LIGO) but it's tough nonetheless," she said, referring to the Laser Interferometer Gravitational-Wave Observatory, a huge collaboration that involves more than 1,000 scientists across the globe.Originally published on Live Science.

Originally published on Live Science.

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The Major Discoveries That Could Transform the World in the Next Decade - Livescience.com