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Fact Sheet: Adult Stem Cell Research and Transplants …

By Adult Stem Cells

To view as PDF, see: CLI Fact Sheet Adult Stem Cell Research and Transplants

Last updated: November 21, 2017

Adult stem cell transplants are already widely used to the benefit of over a million people.

Adult stem cell transplants are being used to treat dozens of conditions in patients.

[i] Gratwohl A et al., One million haematopoietic stem-cell transplants: a retrospective observational study, Lancet Haematology 2, e91-e100, March 2015. doi:10.1016/S2352-3026(15)00028-9.

[ii]Niederwieser D, Baldomero H, Szer J, Gratwohl M, et al., Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transplant. 51(6):778-785, 2016. doi:10.1038/bmt.2016.18.

[iii] General FAQ. U.S. Department of Health and Human Services, Health Resources and Services Administration. http://bloodcell.transplant.hrsa.gov/about/general_faqs/index.html, accessed August 3, 2016.

[iv] Ballen KK, Gluckman E, Broxmeyer HE, Umbilical cord blood transplantation: the first 25 years and beyond, Blood. 122:491-498, 2013. doi:10.1182/blood-2013-02-453175.

[v] Gratwohl A et al., One million haematopoietic stem-cell transplants: a retrospective observational study, Lancet Haematology 2, e91-e100, March 2015. doi:10.1016/S2352-3026(15)00028-9.

[vi] Search term: http://www.clinicaltrials.gov/ct2/results?term=adult+stem+cell+transplants&type=Intr, accessed August 2, 2016.

[vii] Patel AN et al., Ixmyelocel-T for patients with ischaemic heart failure: a prospective randomised double-blind trial. Lancet 387:2412-2421, 2016. doi: 10.1016/S0140-6736(16)30137-4.

[viii] Steinberg GK, Kondziolka D, Wechsker LR et al., Clinical Outcomes of Transplanted Modified Bone MarrowDerived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study. Stroke. 447: 1817-1824, 2016. doi: 10.1161/STROKEAHA.116.012995; Cox CS, Hetz RA, Liao GP, et al., Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells. Stem Cells. 35:1065-1079, 2017. doi: 10.1002/stem.2538; Hess, DC et al., Safety and Efficacy of Multipotent Adult Progenitor Cells in Acute Ischaemic Stroke (MASTERS): A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Trials. Lancet. 16 (5):360-368, 2017. doi: 10.1016/S1474-4422(17)30046-7; Savitz SI, Misra V, Kasam M, et al., Intravenous Autologous Bone Marrow Mononuclear Cells for Ischemic Stroke. Annals of Neurology. 70:59-69, 2011. doi: 10.1002/ana.22458.

[ix]See Bernaudin F et al., Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease. Blood. 110:2749-2756,2007. doi: 10.1182/blood-2007-03-079665. Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for sickle cell disease.

[x] Lima C, Pratas-Vital J, Escada P, Hasse-Ferreira A, Capucho C, Peduzzi JD. Olfactory Mucosal Autografts and Rehabilitation for Chronic Traumatic Spinal Cord Injury. Neurorehabil Neural Repair January 24:10-22, 2010. doi: 10.1177/1545968309347685; Lima C, Pratas-Vital J, Escada P, Hasse-Ferreira A, Capucho C, Peduzzi JD. Olfactory Mucosa Autografts in Human Spinal Cord Injury: A Pilot Clinical Study. The Journal of Spinal Cord Medicine. 29(3):191-203, 2006.

[xi] Burt RK et al., Association of Nonmyeloablative Hematopoietic Stem Cell Transplantation With Neurological Disability in Patients With Relapsing-Remitting Multiple Sclerosis, JAMA. 313(3):275-284, 2015. doi: 10.1001/jama.2014.17986.

[xii] Cai J et al., Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion, Diabetes Care. 39, 149, 2016. doi: 10.2337/dc15-0171; Gaipov, A et al., Autologous Bone-Marrow-Derived Stem Cells Transplantation in Type 1 Diabetes Mellitus. Nephrol. Dial. Transplant. 31 (suppl 1):i217, 2016. doi: 10.1093/ndt/gfw169.03; DAddio F et al., Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in New-Onset Type 1 Diabetes: A Multicenter Analysis, Diabetes.63(9),3041-3046, 2014.doi:10.2337/db14-0295; Zhao et al., Reversal of type 1 diabetes via islet cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Medicine. 10(3), 2012. doi: 10.1186/1741-7015-10-3; Voltarelli JC and Couri CEB, Stem cell transplantation for type 1 diabetes mellitus, Diabetology & Metabolic Syndrome 1, 4, 2009. doi: 10.1186/1758-5996-1-4; Couri CEB et al., C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus, JAMA 301, 1573-1579, 2009; Voltarelli JC et al., Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus, JAMA. 297, 1568-1576, 2007.

[xiii] Weiss JN, Levy S, Malkin A. Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report. Neural Regen Res 2015; 10:982-8; Weiss JN, Levy S, Benes SC. Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a case report of improvement in relapsing auto-immune optic neuropathy. Neural Regen Res 2015; 10:1507-15.

[xiv] Burt RK et al., Nonmyeloablative Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus, JAMA 295, 527-535, 2006, doi: 10.1001/jama.295.5.527; Illei GG et al., Current state and future directions of autologous hematopoietic stem cell transplantation in systemic lupus erythematosus, Annals of the Rheumatic Diseases 70, 2071-2074, 2011 doi: 10.1136/ard.2010.148049; Szodoray P et al., Immunological reconstitution after autologous stem cell transplantation in patients with refractory systemic autoimmune diseases, Scandinavian Journal of Rheumatology 41, 110-115, 2012, doi: 10.3109/03009742.2011.606788; Alchi B et al., Autologous haematopoietic stem cell transplantation for systemic lupus erythematosus: data from the European Group for Blood and Marrow Transplantation registry, Lupus 22, 245-253, 2013, doi: 10.1177/0961203312470729; Alexander T et al., Autologous hematopoietic stem cell transplantation in systemic lupus erythematosus, Z. Rheumatologie 75, 770-779, 2016, doi: 10.1007/s00393-016-0190-3

[xv]Search term selection: multiple myeloma/plasma cell disease (PCD) http://bloodcell.transplant.hrsa.gov/RESEARCH/Transplant_Data/US_Tx_Data/Data_by_Disease/national.aspx, accessed August 3, 2016.

[xvi] Press release: The Lancet Hematology: Experts warn of stem cell underuse as transplants reach 1 million worldwide (Feb 26, 2016) http://www.eurekalert.org/pub_releases/2015-02/tl-tlh022515.php, accessed August 2, 2016.

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Fact Sheet: Adult Stem Cell Research and Transplants ...

FDA: Florida Stem Cell Clinic Violates Law | Health News Florida

By Stem Cell Clinics

A South Florida clinic that promotes controversial stem-cell treatments for a wide range of ailments is among the centers receiving a written warning that it is violating federal public health laws.

The U.S Food and Drug Administrations letter was addressed to Dr. Thomas A. Gionis, owner and chief surgeon of the Miami Stem Cell Treatment Center located in Boca Raton. Gionis also owns a stem cell treatment center in Irvine, Calif.

The letter shows that a third Gionis clinic in New York City apparently closed after FDA inspections of all three clinics was carried out from July through September 2015.

Dr. Gionis facilities are among more than 170 clinics across the country that are selling experimental stem cell procedures for dozens of diseases and conditions a mushrooming industry that has flourished despite little evidence of its safety or effectiveness.

Descriptions on the website say that Dr. Gionis and other practitioners inject or infuse a liquid that is said to contain stem cells derived from the patients own fat tissue, removed through liposuction. The clinic lists a large number of illnesses for which it says the treatments are appropriate, including: heart and lung disease, stroke, multiple sclerosis, spinal disc disease and auto-immune problems like lupus.

And his clinics are not the only ones operating in Florida. Internet search indicates this type of stem-cell treatment is available at clinics in Jacksonville, Orlando, St. Petersburg, Sunrise and a number of other sites throughout the state.

The rise of the U.S. stem cell industry illustrates how quickly fringe medicine can outpace government oversight. Over the last five years, academic stem cell researchers say they have watched in dismay as doctors treat patients with experimental techniques that they say could take years, if not decades, to become sound medicine.

"It's sort of this 21st century cutting-edge technology. But the way it's being implemented at these clinics and how it's regulated is more like the 19th century. It's a Wild West," says Dr. Paul Knoepfler, a stem cell researcher at the University of California at Davis.

The FDA letter to Dr. Gionis, dated Dec. 30, provides some insight into how the FDA is addressing the issue. In difficult-to-parse language, it says that the substance that Gionis is processing and injecting amounts to a drug that has not been approved for safety and usefulness.

The writer, Mary Malarkey, director of an office in the FDAs Center for Biologics and Research, says that if Gionis maintains his treatments are part of a clinical trial, as his website suggests, he would need to submit an Investigational New Drug (IND) application to FDA.

The FDA official says an earlier defense by the clinic that the chemical used in the mixture has been changed doesnt make it acceptable without more information.

Health News Florida was not able to reach Dr. Gionis on Monday, but left a message with his staff.

The Associated Press reported last May that entrepreneurial ventures using fat-derived stem cells have proliferated throughout the country. Scientists engaged in authorized stem-cell research said states have not stepped up to regulate the ventures and called on FDA to do so.

The FDA has scheduled a public hearing for April on draft guidelines for fat-derived stem-cell treatments that the agency released a few months ago. That led some to mistakenly think the treatments are being subjected to new regulations, said FDA spokeswoman Sarah Peddicord. She said the regulations went into effect in 2005.

The law has not changed, she said. What the agency released are guidelines that FDA hopes will help the industry and the public understand the law.

People need to understand how to implement the regulations, she said. The guidelines are just to explain the regulations.

Stem cells have long been recognized for their ability to reproduce and regenerate tissue. And while there are high hopes that they will someday be used to treat a range of debilitating diseases, critics say stem cell entrepreneurs have little more than anecdotes to support their offerings.

In 2010, there were only a handful of doctors promoting stem cell procedures in the U.S., mainly plastic surgeons promoting "stem cell facelifts" and other cosmetic procedures. But today there are clinics throughout the country promoting stem cells for dozens of conditions and diseases, including Alzheimer's, arthritis, erectile dysfunction and hair loss. The cost of these procedures is high, ranging from $5,000 to $20,000.

Many of the businesses are linked in large, for-profit chains which offer doctors the chance to join the franchise after taking a seminar and buying some equipment.

The largest of these chains is the Cell Surgical Network, co-founded in 2012 by Dr. Mark Berman, who spent 30 years as a Beverly Hills plastic surgeon before working with stem cells. His company offers stem cell procedures for more than 30 diseases and conditions, including Lou Gehrig's disease, multiple sclerosis and arthritis.

He and his partner adapted technology from Asia into a liposuction-based procedure in which fat is pumped out of patients' abdomen, processed with drugs and equipment and then injected back into the body.

Berman says this fat-based "soup," is rich in shape-shifting stem cells that have the potential to treat everything from neurological diseases to achy joints.

"I don't even know what's in the soup," says Berman. "Most of the time, if stem cells are in the soup, then the patient's got a good chance of getting better."

The clinics insist that their treatments are safe, but routinely require that patients sign waivers.

Patients of Dr. Zannos Grekos, a Florida cardiologist specializing in stem cell therapy, were also required to sign a consent form, acknowledging the procedures' risks, including death.

But families of two Grekos patients who died under his care say he downplayed the risks. Gina Adams, daughter of patient Richard Poling, says her family was told her father would be "back on the golf course the next day" after a procedure intended to treat a lung condition that made breathing difficult. The cost was $8,000.

In March 2012, Grekos harvested fat from Poling's abdomen and sent it to an off-site processing facility to isolate the stem cells. Later that afternoon, he directed an assistant to infuse the resulting mixture into the patient's bloodstream.

Poling suffered cardiac arrest and was pronounced dead after being rushed to a local hospital.

Two years earlier, in 2010, 69-year old Domenica Fitzgerald suffered a stroke after Grekos infused unfiltered bone marrow-derived stem cells into the arteries of her brain. The state report concluded "it was virtually inevitable that the procedure would clog blood vessels in the brain and cause a major and very possibly fatal stroke." Fitzgerald suffered severe brain damage and was removed from life support several days later.

Jack Fitzgerald says his wife, who used a wheel chair, had hoped that stem cells might help her walk again.

Not until 2013, after Poling's death, did the Florida Board of Medicine vote to revoke Grekos' license.

Though barred from practicing medicine in Florida, Grekos continues to treat patients in the Dominican Republican through his company Regenocyte, which promotes treatments for autism, dementia and many other diseases.

He believes the two deaths were unrelated to his care the state targeted him to discourage other doctors from working with stem cells, he says.

State actions against stem cell doctors are rare. That's led industry critics to conclude that regulation must come from the FDA, which regulates medical products on a national level.

But the FDA's authority to regulate stem cell procedures is not clearly defined and has been debated by legal experts for years.

Now, the FDA appears to be stepping up its oversight. In the last days of 2014, it released draft guidelines dealing with the popular fat-based stem cell technique. The agency said that processing fat to extract stem cells for medical use essentially creates a new drug, which cannot be sold in the U.S. without the agency's approval.

But many stem cell doctors continue to argue that they don't need FDA permission because they are not creating drugs, but performing in-office surgical procedures.

For now, Berman says he has no plans to change his business.

"How is it unethical if you're actually helping people, even if we don't have evidence-based studies to prove it?" he asks.

Carol Gentry is a special correspondent for WUSF in Tampa. Health News Florida receives support from the Corporation for Public Broadcasting.

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FDA: Florida Stem Cell Clinic Violates Law | Health News Florida

Stem Cell Doctors – regenocyte.com

By Stem Cell Doctors

Mary Holler, age 82, of Marco Island Florida is smiling again. Mary was suffering from dementia.

She and her husband sought Stem Cell Dementia Treatment.

She felt uneasy with her ability to function on a daily basis. Now, after undergoing a successful stem cell dementia treatment earlier this month, Mary is her old self again. She doesnt ask her husband, Peter, the same question 3-4 times in an hour anymore. Peter Holler, age 83, had become very concerned that his wife of 60 years was slowly losing her memory. She had been on medications for memory loss for several years but the deterioration in her recall accelerated in the last six months.It was starting to wear on him. He was losing his wife right in front of his eyes. Marys poor performance on an in-depth memory test revealed that that she was so advanced that should be in an assisted living facility. This frightened both the Hollers and their children.

Peter Holler sought out stem cell dementia treatment. He felt it was his wifes only option. Peter, no stranger to stem cells, had undergone a stem cell treatment by Dr. Zannos Grekos for his failing heart in 2008. He had experienced great success. Even my lung function improved dramatically, he recalls. Going back to the same group that he had trusted, he made arrangements to get the love of his life treated.

A track record of several successfully treated patients with dementia already existed. So the doctors knew exactly what to do. Heading the team is Dr. Hector Rosario, an interventional cardiologist and head of the stem cell program in the Dominican Republic. Dr Roberto Fernandez DeCastro head of the catheterization lab assisted in the procedure. Dr Grekos, Chief Scientific Officer for the company was present as well. Its very exciting to be able to have such a positive impact on a disease process that otherwise has such a grim prognosis, Grekos explained. The Dementia Treatmentprotocol used to treat Mrs. Holler had been developed specifically for patients with dementia by Dr Zannos Grekos.

Below arebefore(top) and after (bottom) angiogramsof Mrs. Hollers left internal carotid injections:

Stem cells collected from Marys bone marrow are subjected to an activation and concentration process. The stem cells were then injected into her cerebral circulation. Look at the difference, Dr Rosario exclaimed while pointing to the before and after pictures of the brain circulation. The increase in blood vessel flow was astonishing.Since only adult stem cells from the patient are used, the political, ethical, and medical issues are avoided and there is no risk of rejection.

Were able to normalize a patients neuro-cognitive (brain function) testing in 6 months after the stem cell dementia treatment said Zannos Grekos MD, commenting on the success of patients having received adult stem cell dementia treatment to reverse the effects of dementia. Peter Holler agrees, Not only does she not repeat questions any more, but she is also remembering things that she had forgotten. Its a godsend.

Dementia is a loss of brain function that occurs with age and certain diseases. Most types of dementia are nonreversible (degenerative).It affects memory, thinking, language, judgment, and behavior. Alzheimers disease is a common type of dementia.Dementia also can be due to many small strokes or poor circulation. This is called vascular dementia. Many dementias have a vascular component; these are referred to as mixed dementias. Stem cells are especially effective in treating these types of dementias.

Dr. Zannos Grekos colleagues in the world medical field are currently employing adult stem cell therapy and coordinating its application for patients who have exhausted all other traditional therapy options. His presentation at the 16th Annual World Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies conference supports efforts by a global community of doctors that are striving to incorporate adult stem cell therapy into mainstream medicine.

Regenocyteis an international corporation located in Bonita Springs, Florida. Dedicated to leading the world in providing Adult Stem Cell therapies, Regenocyteutilizes the most effective and safest technologies and medical procedures in order to improve the lives of its patients. A video of Dr. Zannos Grekos presentation at the 16th Annual World Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies is available for viewing on the companys website. Additional information on adult stem cell therapy as well as patient video experiences can be found at http://www.regenocyte.comor call (866) 216-5710.

To learn more about dementia please click here

For more information on Doctor Grekos, MD please click here

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Stem Cell Doctors - regenocyte.com

Top Regenerative Medicine Doctors | Stem Cell Centers

By Stem Cell Doctors

We are actively involved in IRB (Institutional Review Board also known as the Independent Ethics Committee) reviewed research for many different conditions in the regenerative medicine field. By doing so, we have developed (and continue to develop) many protocols and standards for others in our specialty field to utilize. As a leading practice in regenerative medicine, a unique feature within our clinics is that we don't rely on just one type of stem cell. Each of our clinics offers amniotic andconcentrated cord blood and bone marrowstem cells.

We have multiplelocations across the country with many more coming soon. Youll be glad to know that we retain protocol consistency within all our clinics. That means that along with a successful treatment, youll find care, respect, and understanding regardless of which clinic you visit. So if you refer a friend or loved one to one of our Stem Cell Centers, theyll be sure to receive the same great care as you did.

Are you a candidate? Click Here to learn more.

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Top Regenerative Medicine Doctors | Stem Cell Centers

Rheumatoid Arthritis Stem Cell Treatment | StemGenex

By Stem Cell Treatment

Stem Cell Therapy for Rheumatoid Arthritis

Today, new treatments and advances in Rheumatoid Arthritis research are giving new hope to people affected by Rheumatoid Arthritis. StemGenexStem Cell Research Centreprovides stem cell therapy for Rheumatoid Arthritis to help those with unmet clinical needs achieve optimum health and better quality of life. A clinical study registered through the National Institutes of Health (NIH) atwww.clinicaltrials.gov/stemgenex has been established to evaluate the quality of life changes in individuals with Rheumatoid Arthritis following stem cell therapy.

Stem cell therapy for Rheumatoid Arthritis is being studied for efficacy in improving the complications in patients through the use of their own stem cells. These Rheumatoid Arthritis therapies may help patients who dont respond to typical drug treatment, want to reduce their reliance on medication, or are looking to try stem cell therapy before starting drug treatment.

To learn more about becoming a patient and receiving stem cell therapy through StemGenex Stem Cell Research Centre, please contact one of our Patient Advocates at (800) 609-7795.Below are some frequently asked questions about stem cell treatment for Rheumatoid Arthritis.

Rheumatoid Arthritis is an autoimmune disease that attacks the bodys own tissues, specifically the synovium, a thin membrane that lines the joints. As a result of the attack, fluid builds up in the joints, causing pain in the joints and inflammation thats systemic.

Rheumatoid Arthritis (RA) is a chronic disease that can lead to long-term joint damage, resulting in chronic pain and loss of function and disability. Individuals suffering with Rheumatoid Arthritis can experience intermittent bouts of intense disease activity, called flares. In some individuals, the disease is continuously active and progressively becomes worse over time while others enjoy long periods of remission with no disease activity or symptoms. Early diagnosis and aggressive stem cell treatment for Rheumatoid Arthritis can potentially help improve patients' quality of life.

Stem cells that come from your adipose (fat) tissue have distinct functional properties including immunomodulatory and anti-inflammatory functional properties which have the capability of repairing and regenerating damaged tissue associated with disease and injury.

Upholding the highest levels of ethical conduct, safety and efficacy is our primary focus. Five clinical stem cell studies for Parkinson's Disease, Multiple Sclerosis, Osteoarthritis, Rheumatoid Arthritis and Chronic Obstructive Pulmonary Disease (COPD) are registered through the National Institutes of Health (NIH) at http://www.clinicaltrials.gov/stemgenex. Each clinical study is reviewed and approved by an independent Institutional Review Board (IRB) to ensure proper oversight and protocols are being followed.

Stem cells are the basic building blocks of human tissue and have the ability to repair, rebuild, and rejuvenate tissues in the body. When a disease or injury strikes, stem cells respond to specific signals and set about to facilitate the healing process by differentiating into specialized cells required for the bodys repair.

There are four known types of stem cells which include:

StemGenex provides autologous adult stem cells (from fat tissue) where the stem cells come from the person receiving treatment.

StemGenex provides autologous adult adipose-derived stem cells (from fat tissue) where the stem cells come from the person receiving treatment.

We tap into our bodys stem cell reserve daily to repair and replace damaged or diseased tissue. When the bodys reserve is limited and as it becomes depleted, the regenerative power of our body decreases and we succumb to disease and injury.

Three sources of stem cells from a patients body are used clinically which include adipose tissue (fat), bone marrow and peripheral blood.

Performed by Board Certified Physicians, dormant stem cells are extracted from the patients adipose tissue (fat) through a minimally invasive mini-liposuction procedure with little to no downtime.

During the liposuction procedure, a small area (typically the abdomen) is numbed with an anesthetic and patients receive mild to moderate sedation. Next, the extracted dormant stem cells are isolated from the fat and activated, and then comfortably infused back into the patient intravenously (IV) and via other directly targeted methods of administration. The out-patient procedure takes approximately four to five hours.

StemGenex provides multiple administration methods for Rheumatoid Arthritis patients to best target the disease related conditions and symptoms which include:

Since each condition and patient are unique, there is no guarantee of what results will be achieved or how quickly they may be observed. According to patient feedback, many patients report results in one to three months, however, it may take as long as six to nine months. Individuals interested in stem cell therapy are urged to consult with their physician before choosing investigational autologous adipose-derived stem cell therapy as a treatment option.

In order to determine if you are a good candidate for adult stem cell treatment, you will need to complete a medical history form which will be provided by your StemGenex Patient Advocate. Once you complete and submit your medical history form, our medical team will review your records and determine if you are a qualified candidate for adult stem cell therapy.

StemGenex team members are here to help assist and guide you through the patient process.

Patients travel to StemGenex located in Del Mar, California located in San Diego County for stem cell treatment from all over the United States, Canada and around the globe. Treatment will consist of one visit lasting a total of three days. The therapy is minimally invasive and there is little to no down time. Majority of patients fly home the day after treatment.

We provide stem cell therapy for a wide variety of diseases and conditions for which traditional treatment offers less than optimal options. Some conditions include Multiple Sclerosis, Parkinson's Disease, Rheumatoid Arthritis, Osteoarthritis and Chronic Obstructive Pulmonary Disease (COPD).

The side effects of the mini-liposuction procedure are minimal and may include but are not limited to: minor swelling, bruising and redness at the procedure site, minor fever, headache, or nausea. However, these side effects typically last no longer than 24 hours and are experienced mostly by people with sensitivity to mild anesthesia. No long-term negative side effects or risks have been reported.

The side effects of adipose-derived stem cell therapy are minimal and may include but are not limited to: infection, minor bleeding at the treatment sites and localized pain. However, these side effects typically last no longer than 24 hours. No long-term negative side effects or risks have been reported.

StemGenex provides adult stem cell treatment with mesenchymal stem cells which come from the person receiving treatment. Embryonic stem cells are typically associated with ethical and political controversies.

The FDA is currently in the process of defining a regulatory path for cellular therapies. A Scientific Workshop and Public Hearing Draft Guidances Relating to the Regulation of Human Cells, Tissues or Cellular or Tissue-Based Products was held in September 2016 at the National Institutes of Health (NIH) in Bethesda, MD. Currently, stem cell treatment is not FDA approved.

In March 2016, bipartisan legislation, the REGROW Act was introduced to the Senate and House of Representatives to develop and advance stem cell therapies.

Stem cell treatment is not covered by health insurance at this time. The cost for standard preoperative labs are included. Additional specific labs may be requested at the patients expense.

Joint inflammation is a hallmark of rheumatoid arthritis. That includes: Stiffness, Swelling, Pain, Redness and Warmth, Fatigue, Malaise, Loss of Appetite and Muscle Aches.

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Rheumatoid Arthritis Stem Cell Treatment | StemGenex

Stem Cell Therapy for Knees vs Surgery – Which Works Best?

By Stem Cell Treatment

Risks and Benefits of Stem Cell Therapy for Knees

We are already aware of the several risks associated with knee replacement surgery. Theyre big and scary. When you choose stem cell therapy as an alternative for knee replacement, however, most of those risks evaporate. The biggest risk youll face is the risk of infection, but that is extremely rare because the procedure is so minimally invasive.

The benefits of stem cell treatment for knees, on the other hand, are huge. Check it out:

The procedure is relatively quick, especially compared to surgery. We have our equipment and labs in-house, and the outpatient procedure can be done in a single day (a few hours, to be more precise).

The costs involved are reasonable. Your initial consultation, exam, and treatment planning are all done for at a low cost to help reduce your treatment expenses.

Stem cell therapy for knees is natural. We do not produce synthetic stem cells. We dont even use donor cells from embryos or other adults. Instead, we use your own stem cells. We literally take your stem cells from one part of your body and inject them into your knees or other problem areas. And the entire treatment is done in one sitting. It is as natural as you can get!

Recovery time is minimal. With surgery, the recovery time can last for months, many of which you spend immobile or with your mobility severely limited. With stem cell knee injections, this is not the case. You walk in and walk out of the procedure on your own, and your daily routine should stay the same. In a few weeks, you begin to increase your activity levels and do more!

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Stem Cell Therapy for Knees vs Surgery - Which Works Best?

Crohn’s disease patients test experimental stem cell …

By Stem Cell Treatment

It's a painful, chronic, and for some, untreatable condition. More than 700,000 Americans suffer from Crohn's disease, an inflammatory bowel disease that causes inflammation of the digestive tract that can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition.

Now, scientists in the UK have launched a new clinical study to test the use of a stem cell treatment for the inflammatory bowel disease.

Moeed Majeed has struggled to control his Crohn's disease for the past eight years.

"I remember suddenly getting a lot of pain in my abdominal area, having to go to the bathroom a lot more, which was very unusual, and I wasn't eating a lot because it made me feel sick," he told CBS News.

The chronic pain and fatigue became so debilitating he had to drop out of college and move home.

A new clinical trial at Queen Mary University of London is working to help people like Majeed whose symptoms aren't responsive to available drugs and surgery.

"What we're doing is using a patient's own stem cells to reset their immune system," said lead trial investigator Professor James Linsday.

Study participants with Crohn's receive chemotherapy to wipe out their faulty immune system. Doctors then use a stem cell transplant and hormone treatments to grow a new one.

Linsday says it's an intense treatment to combat what he calls a devastating disease.

"Anything that we can do that takes away the duration of that suffering is an excellent thing," he said.

The UK trial is a joint partnership with Bart's Health NHS. The same type of stem cell treatment has already been successful in treating multiple sclerosis and arthritis.

Majeed is documenting his health journey online. He's spent more than two months in the hospital and years trying to find a treatment that works.

"The trials are great. I think it's an awesome thing, especially with people looking to maybe find a cure," he said.

The stem cell trial will last about four years. British scientists say they see real potential for this approach to improve the lives of Crohn's patients.

2018 CBS Interactive Inc. All Rights Reserved.

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@ Stem Cell Treatment For Diabetes Diabetes Care Ada …

By Stem Cell Treatment

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The Stem Cell Treatment Process – regenocyte.com

By Stem Cell Treatment

Once you have decided this is the best option for you, we will determine if any other testing is needed which can be done at our facilities in Florida or wherever you live. We will then plan a date for your stem cell procedure in the Dominican Republic. The process begins with the extraction of bone marrow from the top of you pelvis and also from adipose tissue (fat) at the hospital. In our lab, the stem cells will be activated and multiplied by using naturally occurring growth factors. In this process of activation, the stem cells are customized for the purpose for which they will be used in treatment. For example, they can be activated to build muscle tissue for the heart, to rebuild blood vessels in the extremities or lungs or into neural cells for the central nervous system. This process is done overnight.

The following day the activated cells are returned to the patients body by a process which delivers the stem cells to the part of the body that is being treated. You will be informed of your actual reinsertion method as part of the course of treatment developed specifically for you and your injury or disease.

Once your procedure is completed you will spend anywhere from a few hours, to two days in the hospital depending on your specific treatment and your baseline condition. A full report regarding your procedure will be prepared by the treating physicians and will be sent home with you. You will be given follow up instructions and a schedule of follow-up tests to evaluate your progress. Periodically, you will be contacted by our patient care team with interpretation of your test results and to answer any questions you may have.

Our stem cell clinic will help coordinate all of your travel and transportation arrangements. You arrive at the Santo Domingo International Airport in the Dominican Republic and your transportation coordinator will be waiting for you just outside of the airport. They will have a placard with your name on it. Our team will coordinate with you while you are in the Dominican Republic, including transportation to and from the airport, the hotel, and the hospital.

Be advised that a valid passport is required for entry into the Dominican Republic. Information regarding obtaining a United States passport can be found at: The United States Department of State

We have successfully treated patients from all over the world. We pride ourselves in providing the best, most advanced treatment worldwide and look forward to talking with you, your family or friends regarding the possibility of having Regenocyte Stem Cell Therapy change your life.

To get started with evaluation or more information. Contact our stem cell clinic here or call us at (866) 216-5710

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The Stem Cell Treatment Process - regenocyte.com

Stem Cell Quick Reference – Learn.Genetics

By Somatic Stem Cells

Are you confused about all the different types of stem cells? Read on to learn where different types of stem cells come from, what their potential is for use in therapy, and why some types of stem cells are shrouded in controversy.

Researchers are working on new ways to use stem cells to cure diseases and heal injuries. Learn more about unlocking stem cell potential.

Somatic stem cells (also called adult stem cells) exist naturally in the body. They are important for growth, healing, and replacing cells that are lost through daily wear and tear.

Stem cells from the blood and bone marrow are routinely used as a treatment for blood-related diseases. However, under natural circumstances somatic stem cells can become only a subset of related cell types. Bone marrow stem cells, for example, differentiate primarily into blood cells. This partial differentiation can be an advantage when you want to produce blood cells; but it is a disadvantage if you're interested in producing an unrelated cell type.

Most types of somatic stem cells are present in low abundance and are difficult to isolate and grow in culture. Isolation of some types could cause considerable tissue or organ damage, as in the heart or brain. Somatic stem cells can be transplanted from donor to patient, but without drugs that suppress the immune system, a patient's immune system will recognize transplanted cells as foreign and attack them.

Therapy involving somatic stem cells is not controversial; however, it is subject to the same ethical considerations that apply to all medical procedures.

Embryonic stem (ES) cells are formed as a normal part of embryonic development. They can be isolated from an early embryo and grown in a dish.

ES cells have the potential to become any type of cell in the body, making them a promising source of cells for treating many diseases.

Without drugs that suppress the immune system, a patient's immune system will recognize transplanted cells as foreign and attack them.

When scientists isolate human embryonic stem (hES) cells in the lab, they destroy an embryo. The ethical and legal implications of this have made some reluctant to support research involving hES cells. In recent years, some researchers have focused their efforts on creating stem cells that don't require the destruction of embryos.

Learn more about the controversy behind embryonic stem cells and why new stem-cell technologies may bring it to an end. The Stem Cell Debate: Is It Over?

Induced pluripotent stem (iPS) cells are created artificially in the lab by "reprogramming" a patient's own cells. iPS cells can be made from readily available cells including fat, skin, and fibroblasts (cells that produce connective tissue).

Mouse iPS cells can become any cell in the body (or even a whole mouse). Although more analysis is needed, the same appears to be true for human iPS cells, making them a promising source of cells for treating many diseases. Importantly, since iPS cells can be made from a patient's own cells, there is no danger that their immune system will reject them.

iPS cells are much less expensive to create than ES cells generated through therapeutic cloning (another type of patient-specific stem cell; see below). However, because the "reprogramming" process introduces genetic modifications, the safety of using iPS cells in patients is uncertain.

Therapy involving iPS cells is subject to the same ethical considerations that apply to all medical procedures.

Therapeutic cloning is a method for creating patient-specific embryonic stem (ES) cells.

Therapeutic cloning can, in theory, generate ES cells with the potential to become any type of cell in the body. In addition, since these cells are made from a patient's own DNA, there is no danger of rejection by the immune system.

In 2013, for the first time, a group of researchers used therapeutic cloning to make ES cells. The donor nucleus came from a child with a rare genetic disorder. However, the cloning process remains time consuming, inefficient, and expensive.

Therapeutic cloning brings up considerable ethical considerations. It involves creating a clone of a human being and destroying the cloned embryo, and it requires a human egg donor.

APA format:

Genetic Science Learning Center. (2014, July 10) Stem Cell Quick Reference. Retrieved September 07, 2018, from https://learn.genetics.utah.edu/content/stemcells/quickref/

CSE format:

Stem Cell Quick Reference [Internet]. Salt Lake City (UT): Genetic Science Learning Center; 2014 [cited 2018 Sep 7] Available from https://learn.genetics.utah.edu/content/stemcells/quickref/

Chicago format:

Genetic Science Learning Center. "Stem Cell Quick Reference." Learn.Genetics. July 10, 2014. Accessed September 7, 2018. https://learn.genetics.utah.edu/content/stemcells/quickref/.

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