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Could Newborn Heart Stem Cells Jump-Start Old Hearts? – Sioux City Journal

TUESDAY, Aug. 15, 2017 (HealthDay News) -- Stem cells from young hearts might breathe new life into aging ones, research in rats suggests.

In the study, a special type of stem cells was taken from the hearts of newborn rats and injected into the hearts of old rats, average age 22 months. Other rats from the same age group were given saline shots instead.

Baseline heart function was measured in all the rats, using echocardiograms, treadmill stress tests and blood analysis. The group of older rats underwent an additional round of testing one month after receiving the stem cells from the hearts of the young rats.

The old rats who were given stem cells showed better heart function, a 20 percent increase in exercise capacity and, oddly enough, an improved ability to regrow hair.

"Our previous lab studies and human clinical trials have shown promise in treating heart failure using cardiac [heart] stem cell infusions," said co-primary investigator Dr. Eduardo Marban, director of the Cedars-Sinai Medical Center Heart Institute in Los Angeles.

"Now we find that these specialized stem cells could turn out to reverse problems associated with aging of the heart," he said in an institute news release.

"The way the cells work to reverse aging is fascinating," Marban added. "They secrete tiny vesicles that are chock-full of signaling molecules such as RNA and proteins. The vesicles from young cells appear to contain all the needed instructions to turn back the clock."

But more research is needed, the investigators said.

"This study didn't measure whether receiving the [specialized] cells extended life spans, so we have a lot more work to do," added co-primary investigator Dr. Lilian Grigorian-Shamagian. She is a postdoctoral researcher at Cedars-Sinai.

"We have much to study, including whether [heart stem cells] need to come from a young donor to have the same rejuvenating effects," Grigorian-Shamagian explained.

The findings were published Aug. 14 in the European Heart Journal.

The U.S. National Heart, Lung, and Blood Institute offers a guide to a healthy heart.

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Could Newborn Heart Stem Cells Jump-Start Old Hearts? - Sioux City Journal

Former Hollywood Stuntman Raising $10,000 For His Stem Cell … – DNAinfo

Len Richard (left) and actor Terrance Howard on the set of "Empire" in 2015. View Full Caption

Provided by Len Richard

CHICAGO Len Richard used to fight in movie scenes as a stuntman, but now hes fighting for his life.

Diagnosed with liver disease in 2009, hes been placed on the liver and kidney transplant list to replace his rapidly failing organs. Hes opted to have stem cell replacement therapy in place of the transplant, but his insurance wont cover it, so hes raising $10,000 through YouCaring.

The 44-year-old Englewood native said hes desperate to live a healthy life and doesnt want to risk trying the transplant. Theres the fear that the new organs wont work for long and hell constantly get sick from the anti-rejection medications hell have to take, he said.

Once I understood how stem cell works and how it cures people, it was a no-brainer, Richard said. I rather do that than have someone's organs.

More than 5,000 liver transplants in the United States take place each year, according to the "Stem Cell Therapy for Liver Diseases," a review article published in the Journal of Stem Cell Research and Therapy. About 20,000 people are waiting for a transplant, but only 7,000 procedures are performed each year, and up to 1,500 patients die each year waiting.

Use of stem cells to cure liver diseases has been proved beneficial in most of the conditions, according to the article. Scientific literature reveals the role of stem cells in treatment and cure of various diseases like liver cirrhosis, end stage liver failure, genetic liver disease and also the liver cancer. The stem cells possess the ability to renew and multiply by them or stem cells possess special characteristics of regenerating themselves.

Besides being hospitalized twice in eighth grade for a high fever and an enlarged liver and spleen, Richard has lived a fairly healthy life, he said. He had no major health problems in high school or college.

As an adult, he worked behind the scenes in the control room at Channel 50, before moving to Los Angeles in 1998 for a similar television job. Thats when his life changed.

He was at a gym working out and got invited to train with a group who worked as stuntmen, he said.

A stunt coordinator saw me and said that I looked like Omar and Cuba Gooding, Richard said. He hired me for 'Baby Boy.' Thats how I got into doing stunts.

That job led to other jobs in major films, including "Barbershop" and "Transformers."

Everything was going well for Richard, he said, until 2008 when he tore his rotator cuff during filming for the movie "First Sunday," starring Ice Cube and Katt Williams.

I had surgery, and the person I was seeing at the time noticed that I started losing weight and was going to the bathroom a lot, Richard said.

When he went to the doctor for a routine checkup, he learned that he was diabetic. The doctor reviewed his medical history and asked if he has ever been evaluated for a liver transplant.

In 1987, when he was 13, he mysteriously became ill, he said. He was in the hospital for a high fever and the doctors noticed that his liver and spleen were enlarged, but didnt know why. He was sent home only to return a few days later.

I spent the whole summer in the hospital, Richard said. They did exploratory abdominal surgery and took a sample of all of my organs. They sent it to the CDC and other labs and came back with nothing.

Now that hes on the transplant list, Richard is hoping that hes able to raise enough money to travel to see a doctor in Mexico who was recommended by another patient and have the alternative procedure instead.

I want to avoid the transplant and keep my organs, Richard said.

He said he misses his old life, although he did more recently work on the show "Empire." Hes on disability now, but wants to return to work and the gym.

I was always in the gym, used to go hiking a lot, but now I work out when I feel like it, he said. I have low energy, and its kind of hard right now. I'll ride a bike and try to do air squats, but I was doing crossfit before it became too much for me.

Nobody wants to be sick. Id like to be back in California, moving around. I just get tired of going to doctor, getting poked and having having them tell me I need a transplant. Its mentally draining, and it's scary.

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Former Hollywood Stuntman Raising $10,000 For His Stem Cell ... - DNAinfo

Bone Marrow Transplant gives local cancer patient more time with his family – KTBS

ARZ050-051-059>061-070>073-LAZ001>006-010>014-017>022-TXZ097-151>153-165>167-192100-/O.NEW.KSHV.HT.Y.0009.170819T1500Z-170820T0000Z/Sevier-Howard-Little River-Hempstead-Nevada-Miller-Lafayette-Columbia-Union-Caddo-Bossier-Webster-Claiborne-Lincoln-De Soto-Red River-Bienville-Jackson-Ouachita-Sabine-Natchitoches-Winn-Grant-Caldwell-La Salle-Bowie-Panola-Nacogdoches-Shelby-Angelina-San Augustine-Including the cities of De Queen, Nashville, Mineral Springs, Dierks, Ashdown, Hope, Prescott, Texarkana, Stamps, Lewisville, Bradley, Magnolia, El Dorado, Shreveport, Bossier City, Minden, Springhill, Homer, Haynesville, Ruston, Farmerville, Bernice, Mansfield, Stonewall, Logansport, Coushatta, Martin, Arcadia, Ringgold, Gibsland, Jonesboro, Monroe, Many, Zwolle, Pleasant Hill, Natchitoches, Winnfield, Colfax, Montgomery, Dry Prong, Clarks, Grayson, Columbia, Jena, Midway, Olla, Carthage, Nacogdoches, Center, Lufkin, San Augustine, Hemphill, and Pineland242 AM CDT Sat Aug 19 2017...HEAT ADVISORY IN EFFECT FROM 10 AM THIS MORNING TO 7 PM CDTTHIS EVENING...The National Weather Service in Shreveport has issued a HeatAdvisory, which is in effect from 10 AM this morning to 7 PM CDTthis evening. * EVENT...High pressure across the area will allow for temperatures to climb into the mid 90s this afternoon. Hot temperatures combined with sufficient low-level moisture will allow for heat index values to climb to around 105 to 108 degrees across the advisory area.* TIMING...Heat index values will approach 105 degrees by late morning and persist through the afternoon into the early evening hours.* IMPACT...Precautions should be taken to prevent heat related illnesses, including limiting outdoor work activities to the late morning and early evening hours. PRECAUTIONARY/PREPAREDNESS ACTIONS...Take extra precautions if you work or spend time outside. Whenpossible, reschedule strenuous activities to early morning orevening. Know the signs and symptoms of heat exhaustion and heatstroke. Wear light weight and loose fitting clothing whenpossible and drink plenty of water. to reduce risk during outdoor work, the occupational safetyand health administration recommends scheduling frequent restbreaks in shaded or air conditioned environments. Anyone overcomeby heat should be moved to a cool and shaded location. Heatstroke is an emergency, call 9 1 1. a heat advisory means that a period of hot temperatures isexpected. The combination of hot temperatures and high humiditywill combine to create a situation in which heat illnesses arepossible. Drink plenty of fluids, stay in an air-conditionedroom, stay out of the sun, and check up on relatives andneighbors.&&$$

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Bone Marrow Transplant gives local cancer patient more time with his family - KTBS

Fair rallies around Ratzloff after cancer diagnosis – Southernminn.com

OWATONNA Its the first time in six years that Matt Ratzloff hasnt been working as part of the Steele County Free Fair grounds crew, but hes not far from their thoughts or their hats.

Ratzloff, the grandson of longtime Fair Board member Gene Fisher, first joined the grounds crew at age 16 and returned every year since. Hes taking a break this year, though, for a very good reason: he was diagnosed in January with Acute Myeloid Leukemia, and spent the first half of the year undergoing chemo, transplants and innumerable doctor visits and hospital stays, as well as being one of the featured cancer patients in this springs From The Heart Run/Walk in Owatonna.

He says its a little weird this year not being out on the fairgrounds with his former coworkers.

I was on the grounds crew for about five years, and grew really close with a lot of these guys, and through grounds crew, got really close with the fair board as well, Ratzloff said. Grounds crew was kind of my summer job when I was in college.

Instead, Ratzloff is only recently returned home from Rochester, where he received a stem cell transplant in June. Normally, he says, doctors want patients to stay close at hand in case of complications for 100 days after such a procedure. In his case, he was able to return home on day 45.

Since then, its just been keeping a close watch on my body, going in for weekly checkups and just trying to recuperate from everything thats happened, he said.

His friends at the fair havent forgotten him. Each year, the grounds crew receives a t-shirt for that years fair, and this years shirt includes a cancer ribbon as the I in the word FIGHT as well as Ratzloffs initials. And his grandfather, Fisher, and fellow fair board member Scott Kozelka went even further, supplying the crew with hats embroidered with Ratzloffs nickname, Ratz.

Throughout all this, the fair has been very supportive of my journey as well, Ratzloff said. Im very fortunate to have these guys.

Fisher said the entire fair community, even extending into the vendors and carnival workers, have rallied around his grandson.

You cant ask for more out of a community than how they treated us, he said, noting hed received several donations just Friday morning from vendors to support Ratzloffs family. Its great to have that kind of community.

And even when the fair packs up on Sunday, the community will continue. Theres a benefit for Ratzloff and his family, to offset some of the considerable costs of his treatment and the months spent in Rochester, planned for next Saturday from 4 p.m. to 8 p.m. at the Owatonna VFW banquet hall. Fisher said there will be live and silent auctions, food from Godfathers Pizza, and other activities, with tickets available at the door or in advance.

Ratzloff, who finished his bachelors degree in criminal justice in December and plans to re-enroll in police academy in Rochester this fall, said hes very thankful the fair has his back.

Its a little different [seeing his friends wear his name on hats], but Im very supported in what the fair has done for me, he said. I wish one day Ill be able to repay all of these people, but its tough to.

William Morris is a reporter for the Owatonna Peoples Press. He can be reached at 444-2372; follow him on Twitter @OPPWilliam

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Fair rallies around Ratzloff after cancer diagnosis - Southernminn.com

Global Stem Cells Group Signs An Agreement With Recell Centro … – Digital Journal

Help people suffering from cancer, establishes opportunities for patients to increase the quality of their lives and will be able to extend the life expectancy

New treatment adds years to cancer diagnoses and quality of life during final years.

Global Stem Cells Group, a global network of doctors, researchers, and students that work together to share information and advancements in the study of stem cell develop and extraction today, this week made a very strategic and important agreement with Recell Centro Clinica, Dr. Ramon Gutierrez in Santiago de Chile.

The agreement, which will provide doctors around the world with protocols that help people suffering from cancer, establishes opportunities for patients to increase the quality of their lives and will be able to extend the life expectancy of those living out their final years battling cancer.

The potential for stem cell integration and advancements with regards to cancer are tremendous, said Dr. Benito Novas, Founder and Owner of Global Stem Cells Group. We are honored to be working with such a regarded institution today, and are confident that our knowledge and infrastructure behind stem cell development will complement Recells cancer research.

To complement the agreement, Global Stem Cells Group and Recell Clinica will be holding their first training this November 10, 2017. The two-day training program will provide doctors with the ability to learn cellular immunotherapy and how it can be implemented with cancer patients. The program will wrap up by going over the protocols necessary to administer the immunotherapy, and equips each student with real-life knowledge and expertise moving forward.

As a clinic that is passionate about providing our patients with a cutting edge chance at survival past a cancer diagnosis, we look forward to our collaboration with Global Stem Cells Group, said Dr. Ramon Gutierrez.

Recell Clinica is the only private clinic in the eighth Latin American region that has an integrated pathological anatomy unit that guarantees full traceability of procedures.

For more information, call +1 305-560-5337 or send an email to info@stemcellsgroup.com.

About Global Stem Cells Group

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Global Stem Cells Group Signs An Agreement With Recell Centro ... - Digital Journal

‘It’s been a nightmare’ | Couple stranded after medical emergency – WXIA-TV

Phillip Kish and Kaitlyn Ross , WXIA 6:37 PM. EDT August 18, 2017

An Atlanta man stranded in California after a serious illness is trying to get back home to spend his final days with his family.

Everything has been thrown into question for the Long family ever since Jeff Long got seriously ill during an experimental treatment in Mexico.

The Long family was running out of options after Jeff Long was diagnosed with ALS in 2014 and degenerative Lyme disease in 2015. Their doctor suggested they try an embryonic stem cell treatment only approved in Mexico.

He's been to heck and back, it's been a nightmare, a nightmare for him, Stacy Long, Jeff's wife, said.

In Mexico, Jeff came down with pneumonia and had to transfer to a hospital in San Diego. He's now so sick, doctors will only release him through a medical flight, which costs $22,300.

Story continues after gallery

The Longs depend on Medicare after Stacy quit her job to care for Jeff full time.

We've both always worked, up until he was disabled, he was a hard worker, always paid our insurance, Stacy Long said. And then when you really badly need it, where's it at?

Stacy said they can't pay for the flight; they're already broke from the experimental treatment.

"If it works, great, if it doesn't, we tried, but never did I imagine in my wildest dreams we would be where we are, ever, she said.

They say they want nothing more than to get back to Atlanta to have the support of their family, but right now, there's no possible way for them to afford it.

Provided by family

It's been so heartbreaking to see him go through this when he wants to go home so badly, Stacy Long said.

For a week, their dog, Elmo, kept Jeff company in the hospital in California, but Jeffs mother had to pick Elmo up.

He can't go back on the medical flight with us, Stacy Long said.

The Longs say their medical insurance refuses to pay to get Jeff home from California, but if they had purchased travel insurance, they would have been covered.

Its such a sad thing, and I don't even know how much travel insurance costs, but if you're in a position like we are, it would be worth it, every cent, Stacy Long said.

Provided by family

Stacy Long says she didn't know much about travel insurance before they went to Mexico.

Especially with his condition, I would have purchased that, she said.

The Longs have a GoFundMe page. For information on how to donate, visit: https://www.gofundme.com/teamlongals-com

2017 WXIA-TV

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'It's been a nightmare' | Couple stranded after medical emergency - WXIA-TV

Sports hype of platelet-rich plasma ‘powerful marketing tool’ but distorts the science – CBC.ca

When injured elite athletes talk aboutusing platelet-rich plasma (PRP), the coverage fuels hype that makes it harder for average consumers to see the limitations of the potential treatment, a new study suggests.

Athletes including American golfer Tiger Woods, NFL quarterback Tom Brady and now-retired NBA playerKobe Bryant have reportedly used the decades-old approach.

When PRP is used in sports medicine circles, theperson's blood is collected and spun to concentrate the platelet component of the fluid, which is then injected back into an injured area, such as a torn tendon.

Tim Caulfield, who holds the Canada Research Chair in health law and policy at the University of Alberta, and his co-authors reviewed newspaper coverage of PRP use between 2009 and 2015in Australia, Canada, Ireland, New Zealand, United Kingdomand the United States. It waspart of their ongoing researchinto what he calls "bunk" or "science hype" exaggeration of the benefits of science and understatement of any risks or other concerns, including instem cell treatments.

"When PRP is covered in the sports pages, it's talked about in a way that if you were just a casual observer of the science, you would assume that this works and that, we think, is a very powerful marketing tool," said Caulfield.

"If you see a story about a pitcher, a football player or track and field star getting PRP and you have an injury and you know of a clinic near you that's offering PRP, I think it does make it seem like it's more legitimate and perhaps that the science is further along than it really is."

In last week's issue of the journal PLOS One, Caulfield and his co-authors reported that a large majority of PRP articles from Australia (97.1 per cent), theU.S. (87.1 per cent)and Canada (79.4 per cent) were sports-related stories.

The exception was in New Zealand, where less than 10 per centwere sports-related. The researchers found that81.8 per centof the articles analyzed were cosmetic stories.

Reality TV star KimKardashianfirst promoted PRPas an anti-aging treatment through thevampire facials she underwenton her show in 2013 to avoid wrinkles.

Caulfieldsaid he sympathizes with sports reporters but he wants the public to recognize how elite athletes are willing to try just about anything, even unproven, because they're desperate to return to play.That doesn't necessarily mean the treatment works.

"To date, the science [for PRP] is far from definitive," he said.

The researchers said their findings raise questions about why there havebeen so few well-conducted, large clinical trials into PRP to truly judge how much it helps or harms.

Dr. Ryan Degen, an orthopedic sports medicine surgeon at Western University in London, Ont., is seeking funding to conduct a clinical trial on PRP.

"The trial that we're going to try to get off the ground is to look at knee arthritis to see if [PRP is]warranted to treat the arthritis or if we should just be sticking with the conventional injections that we've been using," Degen said.

Degen advises athletes to tread cautiously.

Degen tells his patients there are a few possible indicationsto use PRP in sports medicine, but other times, it's not worthwhile, particularly given that the expense can range from $250 to several thousand dollars.

Many people look up to elite and professional athletes.But the study's findings suggest part of the cautionary message around PRP use is lost when athletes are the source of the message, said Dr. Mark Leung, director of the primary care sport and exercise medicine program at theUniversity of Toronto.

For "elite athletes, one of the names of the game is you start to try and compete and win at whatever cost and that may include your health, and so I don't thinkmany individuals [in] the general population may understandthat aspect."

The reality is, PRP injections don't replace an accurate diagnosis and reliable treatments such as exercise, weight management and rehabilitation, Leung said.

"There was some evidence for its use in tennis elbow or in partial tendon tears," said Leung. "I think that evidence is starting to become less clear [on] when to use it and what regimen, because even the way it's been studied has been a bit murky."

For non-elite athletes, Leung suggesteda more moderate approach to diet, workouts and recovery from injuries.

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Sports hype of platelet-rich plasma 'powerful marketing tool' but distorts the science - CBC.ca

Study: Implicit hype? Representations of platelet rich plasma in the news media 5 things to know – Becker’s Orthopedic & Spine

After seeing athletes like Tiger Woods, Tom Brady and Kobe Bryant use platelet rich plasma to treat their injuries, consumers have been more motivated to treat their injuries with the same treatment.

However, a recent study by Tim Caulfield, Canada Research Chair, published in PLOS, showed this form of treatment may be exaggerated by the media.

Here are five things to know:

1. In the United States, 87.1 percent of news articles about platelet rich plasma were sports related stories.

2. Of the articles published about platelet rich plasma, 64.8 percent included a brief description of the procedure while 32.5 percent included a detailed description.

3. Approximately 67 percent of articles portrayed platelet rich plasma injections as a routine procedure and 22 percent portrayed the injections as new or cutting edge.

4. In total, 11.7 percent of the articles published described the injections as being experimental.

5. In the end, 23.8 percent of platelet rich plasma injections articles described the treatment as effective.

More articles on sports medicine: Dr. Neal EIAttrache performs knee surgery on Oklahoma City Thunder's Patrick Patterson: 4 takeaways OrthoAtlanta becomes official sports medicine provider of Chick-fil-A kickoff games: 3 insights Dr. Michael P. Bolognesi to perform knee replacement surgery on Dukes Mike Krzyzewski 4 insights

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Study: Implicit hype? Representations of platelet rich plasma in the news media 5 things to know - Becker's Orthopedic & Spine

Bears continue to mix and match on O-line with Kyle Long limited … – Chicago Sun-Times

With Prospect High School as their setting, the Bears continued to prepare themselves for a future without guard Kyle Long.

Long returned to practice Thursday but didnt participate after undergoing treatment on his surgically repaired right ankle a day earlier.

Coach John Fox said Long met with the doctor who originally performed his surgery in December in Charlotte, North Carolina.

It was pretty convenient, Fox said. We actually planned it about a week ago. Its just timed that way. I thought it went well. And we held him back today. The treatment they did usually requires 24 hours off, but he feels a lot better. Were excited to get him going again.

Bears guard Kyle Long. (AP)

Fox didnt specify which treatment Long underwent, but platelet-rich plasma (PRP) injections, which promote healing, can require a downtime of 24 hours.

With Long out, Hroniss Grasu practiced at center with the first-team offense, and Cody Whitehair was at left guard.

Its a look the Bears experimented with in Bourbonnais, but it also could be their starting look Saturday in the preseason game against the Cardinals.

There is flexibility that we need in the line, Fox said. Well see how it goes and how we start. We still havent met in really how were going to approach the game as a staff yet.

Another possibility is keeping Whitehair at center and playing Grasu at left guard.

[Grasu is] going to have to know both, Fox said. Hes going to have reps at both.

QB order

The Bears will maintain the same order at quarterback against the Cardinals: starter Mike Glennon, backup Mark Sanchez, then No. 3 Mitch Trubisky.

In and out

Linebackers Danny Trevathan (knee) and Nick Kwiatkoski (concussion) and defensive lineman Akiem Hicks (sore Achilles tendon) participated in practice in various capacities.

Cornerback Prince Amukamara (hamstring), defensive lineman Mitch Unrein (concussion) and nickel back Bryce Callahan (ankle) did not participate.

Follow me on Twitter @adamjahns.

Email: ajahns@suntimes.com

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Bears continue to mix and match on O-line with Kyle Long limited ... - Chicago Sun-Times

First-in-man intraglandular implantation of stromal vascular fraction … – Dove Medical Press

Back to Browse Journals International Medical Case Reports Journal Volume 10

Case report

Case reports

Video abstract presented by Kristin Comella.

Views: 12

Kristin Comella,1 Walter Bell2

1US Stem Cell, Inc, Sunrise, FL, USA; 2South African Stem Cell Institute, Parys, South Africa

Background: Stromal vascular fraction (SVF) is a mixture of cells which can be isolated from a mini-lipoaspirate of fat tissue. Platelet-rich plasma (PRP) is a mixture of growth factors and other nutrients which can be obtained from peripheral blood. Adipose-derived stem/stromal cells (ADSCs) can be isolated from fat tissue and expanded in culture. The SVF includes a variety of different cells such as ADSCs, pericytes, endothelial/progenitor cells, and a mix of different growth factors. The adipocytes (fat cells) can be removed via centrifugation. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF and PRP followed by repeat dosing of culture-expanded ADSCs into a patient with severe xerostomia postirradiation. Methods: Approximately 120 mLs of adipose tissue was removed via mini-lipoaspirate procedure under local anesthetic. The SVF was prepared from half of the fat and resuspended in PRP. The mixture was delivered via ultrasound directly into the submandibular and parotid glands on both the right and left sides. The remaining 60 mLs of fat was processed to culture-expand ADSCs. The patient received seven follow-up injections of the ADSCs plus PRP at 5, 8, 16, 18, 23, 28, and 31 months postliposuction. The subject was monitored over a period of 31 months for safety (adverse events), glandular size via ultrasound and saliva production. Results: Throughout the 31-month monitoring period, no safety events such as infection or severe adverse events were reported. The patient demonstrated an increase in gland size as measured by ultrasound which corresponded to increased saliva production. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. The strong safety profile and preliminary efficacy results warrant larger studies to determine if this is a feasible treatment plan for patients postradiation.

Keywords: adipose tissue, ADSCs, cell therapy, MSCs, PRP, stem cells, SVF, xerostomia

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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First-in-man intraglandular implantation of stromal vascular fraction ... - Dove Medical Press