Bayer Opens First Cell Therapy Manufacturing Facility to Advance … – BioSpace

BERLIN, Germany & BERKELEY, Calif.--(BUSINESS WIRE)-- Bayer AG announced today the opening of its first Cell Therapy Launch Facility in Berkeley, California to create the capacity to bring cell therapies to patients on a global scale. The $250 million (USD), 100,000-square-foot facility will supply the material required for late-stage clinical trials and potential commercial launch of BlueRock Therapeutics bemdaneprocel (BRT-DA01), an investigational cell therapy currently in evaluation for treating Parkinsons disease. In addition, it includes space for a second module of production suites to support additional cell therapies as Bayers portfolio advances. BlueRock Therapeutics LP is a clinical stage, cell therapy company and wholly owned, independently operated subsidiary of Bayer AG.

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Cell therapy represent a groundbreaking class of medicines and is an area where Bayer is making a significant investment to research potentially transformative treatment approaches for people with unmet medical needs, said Sebastian Guth, President of Bayer U.S.A. and Pharmaceuticals North America, and member of the Pharmaceutical Executive Committee. Our new cell therapy facility represents true innovation in product development and manufacturing in addition to contributing to Bayers sustainability goal as our first fully electric pharmaceutical manufacturing plant.

The new Cell Therapy Launch Facility is part of a transformation at the companys dedicated biotechnology site in Berkeley, where Bayer has invested nearly USD 500 million in infrastructure over the past five years.

Our teams are driving innovation in late-stage development and manufacturing with a goal of bringing transformational cell and gene therapies to patients on a global scale, and this facility will enable us to make it real, said Jens Vogel, Sr. Vice President and Global Head of Biotech for Bayers Pharmaceutical Division. Bayer is collaborating with biotech innovators, academia, and equipment and automation suppliers to establish platforms that would help bring more therapies to patients faster.

Bayers global biotech organization recognizes the importance of helping innovators transfer their product candidates from the laboratory bench to the clinical study and commercial launch settings. The Biotech team provides its biologic development and manufacturing capabilities for Bayers larger biotherapeutics portfolio, including commercial products and late-stage protein and cell therapies in development. As part of Bayers larger mission of Health for All, the company is now also helping early-stage U.S. and European companies to enable patient trials and commercial launches through its BioPartnering Solutions offerings.

Having access to this Cell Therapy Launch Facility is central to our goal to deliver impactful cell therapies from our pipeline to patients in need, said Seth Ettenberg, President & CEO of BlueRock Therapeutics. Our team is excited to be working shoulder to shoulder with Bayers biotech scientists and manufacturing experts as we look to scale up manufacturing for our first investigational therapy, bemdaneprocel for Parkinsons disease, as it advances through clinical trials.

The new Cell Therapy Launch Facility, launched in conjunction with manufacturing day in the United States, is among several recent investments to advance Bayers biologic pipeline of protein therapeutics, cell and gene therapies including a new Cell Culture Technology Center and Cell Therapy Labs. The new Cell Therapy Launch Facility features flexible, modular space for cell culture, viral transduction and automated filling of cell therapies leveraging Biotech@Bayer expertise in iPSC and CAR-T characterization, process development, analytics and clinical to commercial production.

Beyond Berkeley, the companys global biotech network includes biologic development, manufacturing science, industrialization and advanced manufacturing engineering teams in Wuppertal and Leverkusen, Germany; and Basel, Switzerland; with a full complement of labs and clinical production suites.

About bemdaneprocel and Parkinsons Disease

Bemdaneprocel (BRT-DA01) is an investigational cell therapy designed to replace the dopamine producing neurons that are lost in Parkinsons disease. These dopaminergic neuron precursors are derived from pluripotent stem cells (PSC) that are human embryonic stem cells. In a surgical procedure, these neuron precursors are implanted into the brain of a person with Parkinsons disease. When transplanted, they have the potential to reform neural networks that have been severely affected by Parkinsons and restore motor and non-motor function to patients. Planning is underway for BlueRock Therapeutics Phase II study that is expected to begin enrolling participants in H1 (first half) 2024.

Parkinsons disease is a progressive neurodegenerative disorder caused by the death of nerve cells in the brain, leading to decreased dopamine levels. At diagnosis, it is estimated that patients have already lost 50-80% of their dopaminergic neurons. The loss of these neurons leads to a progressive loss of motor function and symptoms such as tremors, muscle rigidity, and slowness of movement. Even with medication, the symptoms of Parkinsons disease can fluctuate during the course of the day. According to the Parkinsons Foundation, more than 10 million people worldwide suffer from Parkinsons disease, with approximately one million living in the United States. There is no cure, and the effectiveness of current treatments decreases over time.

About BioPartnering Solutions for Biotech Innovators in U.S. and Europe

Through Bayers BioPartnering Solutions, innovators can leverage industry-leading biotech process development and biomanufacturing capabilities to make their therapeutic candidates a reality. Bayers highly skilled Biotech teams and infrastructure which includes preclinical, clinical and commercial launch scale manufacturing are available to advance promising cell therapy, monoclonal antibody and protein therapeutic candidates from the discovery bench to patients. Through BioPartnering Solutions, Bayer provides early-stage companies with a single source of IND- and BLA-enabling development; bioprocess and biochemical engineering; clinical and commercial manufacturing. A range of complementing support service functions such as supply chain management, procurement, quality, and CMC strategy support for regulatory filings are also available. For more information visit: https://www.bayer.com/en/us/BioPartneringSolutions.

About Bayers Biotech Campus in Berkeley, CA

Innovation happens in communities which foster it. Bayer has a 46-acre site located in Berkeley, CA where a team of about 1,000 employees drives the development and manufacturing of traditional protein therapeutics as well as novel cell and gene therapies. It has also served as the global commercial supply center for manufacturing and supplying Bayers biotherapeutics for people living with hemophilia A around the world for 30 years.

During todays event, Bayer celebrated its continuing relationship with the City of Berkeley through a 30-year extension of its Development Agreement which will support up to one million square feet of additional infrastructure. Through the agreement, Bayer will invest more than $30 million in the local community in career technical education; initiatives focused on health equity, economic resiliency and climate action; and more. For more information visit: https://www.bayer.com/en/us/berkeley-site-updates.

About Bayer

Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Its products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Bayer is committed to driving sustainable development and generating a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. The Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2022, the Group employed around 101,000 people and had sales of 50.7 billion euros. R&D expenses before special items amounted to 6.2 billion euros. For more information, go to http://www.bayer.com.

Find more information at https://pharma.bayer.com Follow us on Facebook: http://www.facebook.com/bayer Follow us on Twitter: @BayerPharma

Forward-Looking Statements

This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayers public reports which are available on the Bayer website at http://www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.

View source version on businesswire.com: https://www.businesswire.com/news/home/20231009274687/en/

Bayer U.S.-based Media Contacts: Cathy Keck, +1-206-249-5191 Email: cathy.keck@bayer.com

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Bayer Opens First Cell Therapy Manufacturing Facility to Advance ... - BioSpace

Stem Cell Treatment Discussed with Cerebral Palsy Community – Mirage News

Exploring the boundaries of stem cell therapy, scientists consulted the cerebral palsy community to understand their perspectives.

Dr Courtney McDonald and Dr Madeleine Smith, in collaboration with researchers at the Cerebral Palsy Alliance, surveyed people in the Australian cerebral palsy community to better understand the acceptability of NSC treatment.

They distributed an online survey and received responses from 232 Australians with cerebral palsy, their parents and/or carers.

Cerebral palsy is the most common physical disability of childhood and currently has no known cure. Researchers at Hudson Institute of Medical Research have been investigating neural stem cell (NSC) treatment for cerebral palsy, but not without considering important ethical and practical considerations for the use of NSCs.

Various stem cell therapies are currently being explored for the treatment of cerebral palsy, including some in clinical trials. Advancing stem cell research is a priority for the cerebral palsy community and neural stem cells offer potential as a future regenerative treatment.

The researcher's rationale was that it's much better to engage with the community early in their research, rather than down the track, during clinical implementation.

"NSC treatment for cerebral palsy is complex, and researchers need to consider the therapeutic source of NSCs and how they are administered as a treatment.," Dr Smith said. "For instance, NSCs need to be administered directly into the brain via neurosurgery in order to replaced damaged brain cells. Another significant factor is that they can be obtained from both adult donors as well as embryonic and fetal sources."

This procedure also needs to be accompanied by strong drugs, called immunosuppressants, that help to ensure the NSCs stay in the brain and are not rejected by the body. However, both the invasiveness of neurosurgery and the use of these drugs present treatment risks.

"Via a research survey, we wanted to better understand, given all the complexities, if NSC treatment for cerebral palsy is an acceptable treatment." Dr Smith said.

Natasha Garrity, Research Assistant at Cerebral Palsy Alliance Research Institute and Co-Chair of the CPA Stem Cell Reference Group, welcomed this research as an important opportunity for people living with cerebral palsy and their families to provide their perspectives.

"It is critically important to respect the lived experience of the people with CP receiving this potential treatment and the views of their support network. By involving consumer stakeholders early on in the research process, the treatment can both be better understood by the community and targeted to the groups that are willing to use the treatment option," she said.

"Cerebral Palsy Alliance is committed to and passionate about involving people with a disability and their families in research for the benefit of researchers, clinicians and the CP community."

"Overall, the survey results showed that NSC therapy is deemed acceptable in the community," Dr Smith said. "even with the known complexities of neurosurgery and the need to use immune suppressing drugs."

"The survey also provided important insights into community expectations of NSC treatment there was some hesitancy reported, which is to be expected and we can learn from the various opinions in the community to inform our future research."

Some of the responses from survey participants are listed below:

"If my brother can help himself get ready or be able to transport himself even a little bit without assistance from the family, that would be great."

"I'd love to be able to have better days than worse days. To wake up with no pain."

"It would mean inclusion. And validation to her that she is a valuable asset. Currently she is spoken over, ignored, or spoken down to."

(Anonymous participant quotes)

The findings from this study informs the work that scientists are conducting in the lab so that new treatments are acceptable to the cerebral palsy community. Additionally, this study is a great example of how early collaboration could aid in moving towards timely treatments for the people that need it the most.

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Stem Cell Treatment Discussed with Cerebral Palsy Community - Mirage News

SightCare Reviews – Legit Ingredients or Negative Scam Complaints … – Seattle Weekly

Everyone wishes to have optimal eye health because without it the world can turn bleak. People cannot function or do everyday tasks that seemed so easy once in their lives. Maybe, that is why so many people are supplementing their diet with vision supplements.

One such supplement is Sight Care. The blend of natural ingredients with no side effects is a popular choice in the United States. The official website of Sight Care says that they have helped thousands of people restore their vision naturally.

But is it really as effective as the makers claim? The official website says that you will not need any surgery or feel the need to wear glasses. They even go on to say that it can reverse blindness! That is really shocking and if true, miraculous! To get to the truth, we did exhaustive research.

In this Sight Care review, you will discover everything about the dietary supplement. We will tell you everything we discovered in our research about this vision supplement.

First, lets take a look at the summary:

Category:

Dietary Supplement

Quantity:

Each bottle of SightCare contains 60 capsules

Side Effects:

Customer reviews did not reveal any side effects (See what people are saying!)

Characteristics:

Ingredients:

Bilberry Extract, Eyebright, N-Acetyl-L-Cysteine, Quercetin, L-Lysine, Astaxanthin, Lutein and Zeaxanthin, and others

Money-Back Guarantee:

A 180-day money-back guarantee is available

Free Shipping:

On Select Purchase

Price:

Starts at $69 (Official Website)

Poor eyesight can be caused by several factors. Some of the most common ones are age-related macular degeneration, glaucoma, cataracts, eye infection, etc. Exposure to blue light and hereditary eye conditions can also be the leading causes of poor eye health.

Sight Care supplement was manufactured after Shinya Yamanaka discovered the power of adult repair stem cells. Scientists in the United Kingdom were using stem cell therapy to regenerate eye cells to treat blindness and age-related diseases like cataracts and other eye health problems.

This scientific discovery repaired the retinas of a man in his 80s and a woman in her 60s. Earlier, the test subjects could not even read or see clearly due to poor eye health. But, after the trials, they could read up to 80 words in a minute.

When David and his friend, Mark read this research in the journal they decided to make Sight Care.

The unique feature of SightCare vision health supplement is that despite being a supplement that helps in maintaining healthy vision, it does not stop at eye health benefits only. The vision supplement also promotes your overall well-being.

The health benefits of SightCare vision health formula are innumerable. Well, not literally but they are too many for us to discuss all of them here. You can write books on each ingredients benefits if you wish. That is how many benefits Sight Care supplement has to offer!

SightCare: Try it now, you wont be disappointed!

David Lewis is the creator of the Sight Care eye health supplement. He is an eye specialist and has over 37 years of experience in helping people support healthy eye function.

In his later years, David struggled with blurred and poor eyesight. The cause was age-related macular degeneration. This made David search for a solution along with his friend, Mark. Together they created this blend of natural ingredients to support vision health naturally.

The eye health formula is made in an FDA-approved and GMP-certified facility in the USA. The makers have tested the formula multiple times to ensure that it is clean and effective.

Before you get tempted to buy this supplement to support healthy vision, you should know if it is even made for you. You do not need to make unnecessary purchases and include something in your diet that you do not need.

The official website of the SightCare vision formula claims that anyone between the ages of 19 and 90 can take the supplement. As the ingredients are plant-based, the vision supplement will have no side effects on users.

So, if you are struggling with vision impairment or age-related eye diseases, say age-related macular degeneration, SightCare will be the right choice for you. You are suitable to use it if you want to maintain healthy vision.

SightCare takes a multi-action approach to protect the eyes and promote healthy eye function. Let us give you an overview of how it works in a simple way.

First of all, the SightCare eye supplement works to boost the growth of adult repair stem cells. Adult repair stem cells are free agents which means they have no assigned role. The major function of adult repair stem cells is to assume the role of cells wherever our body or organs require them. In the case of age-related macular degeneration, adult repair stem cells assume the role of eye cells to enhance vision.

Moreover, Sight Care has ingredients with anti-inflammatory properties that induce a healthy inflammatory response to reduce inflammation caused by eye diseases and support healthy vision. The ingredients in the formula protect the eyes from free radicals and blue light to prevent any damage from occurring.

To support healthy eye function and rectify age-related macular degeneration, the Sight Care pills promote blood circulation and keep your blood vessels healthy.

Click here to get all the details about SightCare >>>

Sight Care dietary supplement brings multiple health benefits to you. From the official website and Sight Care reviews, we have gleaned the following health benefits of the Sight Care supplement:

The ingredients in the Sight Care eye formula support healthy vision. As supported by the SightCare reviews, the formula supports overall eye health. The blend of natural ingredients nourishes your eyes and prevents free radicals from damaging your eye tissue. Thus, you get healthy eyes.

The vision supplement also has cell regeneration ability to regenerate eye cells and prevent age-related eye diseases like macular degeneration. This helps in regenerating eye tissues to maintain healthy eyes with clear vision.

Sight Care formula supports liver health. SightCare eye formula has n-acetyl which has antioxidant and anti-inflammatory properties. A healthy inflammatory response protects your liver from inflammation damage and reduces the risk of liver diseases. It helps in detoxifying your body and prevents free radical damage to support a healthy liver.

By promoting healthy liver function, Sigh Care optimizes your overall well-being.

Sight Care also helps improve brain health as supported by the official website and SightCare reviews. N-acetyl has anti-inflammatory properties that protect your brain from inflammation and oxidative stress to improve brain health.

Brain Health supports healthy vision and overall eye health.

Sight Cares natural ingredients also enhance vision to support night vision. Now, you do not have to fumble around or squint hard to see things in the dark.

Sight Care is scientifically proven to specifically target age-related macular disease or macular degeneration which is the leading cause of poor eyesight in older people. Thus, it supports your overall eye health despite your age.

Click here to order your supply of SightCare now and start enjoying its benefits!

SightCare is a revolutionary product that combines the power of Bilberry Extract, Eyebright, N-Acetyl-L-Cysteine, Quercetin, Astaxanthin, Lutein, and Zeaxanthin into one powerful formula.

Its designed to help support healthy eyesight and promote clearer vision so you can get the most out of life with the help of powerful natural ingredients:

A study conducted on the effects of bilberry extract on eye health supports its inclusion in SightCare. In a randomized, double-blind, placebo-controlled trial published in the Journal of Science of Food and Agriculture, researchers looked at the impact of bilberry extract supplementation on visual function in 120 participants with early-stage AMD.

The study found that after six months of bilberry extract supplementation, there was a significant improvement in visual acuity, contrast sensitivity, and macular pigment optical density compared to the placebo group.

According to the study, participants who took the bilberry extract supplement experienced a 25% improvement in visual acuity compared to only 9% in the placebo group. Additionally, their contrast sensitivity increased by 33%, while the placebo group only showed a 13% increase.

At a microscopic level, eyebright contains various bioactive compounds such as flavonoids, iridoids, and tannins. These compounds possess antioxidant and anti-inflammatory properties, which play a key role in maintaining and improving eye health.

Another vital mechanism by which eyebright aids in visual acuity and eyesight protection is its ability to promote blood circulation to the ocular region. The tiny capillaries and blood vessels within the eyes deliver the necessary nutrients and oxygen to maintain the optimal functioning of ocular tissues.

By enhancing blood flow, eyebright ensures that these vital nutrients reach the cells of the eyes, including the retinal cells responsible for signaling and visual perception.

A study conducted by Babizhayev et al. (2016) examined the effects of NAC in patients with early cataracts. The study involved 49 individuals who were divided into two groups: one receiving NAC eye drops and the other receiving placebo eye drops.

The researchers measured various indicators of eye health, including visual acuity, glare sensitivity, and lens transparency, before and after the intervention. The results showed that the group receiving NAC eye drops experienced significant improvements in all measured parameters compared to the placebo group.

Visual acuity improved by 35%, glare sensitivity decreased by 27%, and lens transparency increased by 41%.

Place your order today by clicking here before stock runs out! >>>

Quercetin is a flavonoid compound found in various plant-based foods such as onions, apples, and berries. On a molecular level, quercetin consists of three rings and several hydroxyl groups, which contribute to its antioxidant and anti-inflammatory properties. When it comes to improving visual acuity and protecting eyesight, quercetin plays a crucial role in several core mechanisms.

By inhibiting the production of inflammatory molecules such as cytokines and chemokines, quercetin helps to reduce inflammation in the eyes. This anti-inflammatory action not only alleviates discomfort but also preserves the integrity of ocular tissues and improves visual acuity.

Moreover, quercetin aids in reducing oxidative stress in the eyes. Oxidative stress occurs when there is an imbalance between the production of harmful free radicals and the bodys ability to neutralize them with antioxidants. In the eyes, this oxidative stress can lead to the development of various eye conditions such as cataracts and age-related macular degeneration (AMD).

Astaxanthin is a naturally occurring red pigment that belongs to the carotenoid family. Its chemical composition consists of a central polyene chain with alternating single and double bonds and several end groups called keto and hydroxyl groups. This unique structure gives astaxanthin its powerful antioxidant properties.

When it comes to vision functioning, astaxanthin demonstrates remarkable benefits. It has a strong affinity for the retina and accumulates in the macula, a small area responsible for central vision. Astaxanthin protects the eyes from harmful ultraviolet (UV) radiation and filters out harmful blue light.

It also acts as a potent antioxidant, neutralizing free radicals that can damage the delicate structures of the eye. Furthermore, astaxanthin enhances blood flow to the retina, improving nutrient delivery and oxygenation, which in turn supports optimal vision functioning.

Numerous scientific studies have provided evidence for the effectiveness of lutein and zeaxanthin in supporting eye health and improving night vision. One specific study published in the Journal of the American Medical Association in 2016 examined the effects of these antioxidants on participants with intermediate AMD.

The study found that a combination of lutein and zeaxanthin supplements significantly reduced the progression of AMD and improved visual acuity compared to a placebo group. Specifically, the lutein and zeaxanthin group had a 10% reduction in the risk of progression to advanced AMD, highlighting the powerful protective effects of these antioxidants.

Furthermore, studies have shown that higher levels of lutein and zeaxanthin in the macula are associated with a lower risk of cataracts and improved contrast sensitivity, especially in low-light conditions.

In a study published in the Journal of Optometry in 2017, researchers found that individuals with higher macular pigment optical density (indicating higher levels of lutein and zeaxanthin) had better night vision and were less affected by glare.

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The advantages of purchasing the Sight Care formula are as follows:

The following are the disadvantages of purchasing Sight Care vision health formula:

We compared Sight Care dietary supplement with other eye health supplements to see how it stands apart from them and we were not disappointed. Take a look at the comparison below:

Ocusil is a dietary supplement that supports healthy eyesight. It provides crystal-clear vision and prevents free radicals from damaging your retina.

In terms of pricing, both Ocusil and Sight Care are the same. You can purchase the basic pack for $69 plus shipping charges.

If we talk about the manufacturing of both supplements then like Sight Care, the Ocusil dietary supplement is also made in an FDA-approved and GMP-certified facility ensuring its effectiveness and quality.

However, both supplements have different list ingredients and target different causes of vision loss to help you in maintaining healthy eyesight. You can go through the ingredient list of both supplements and decide which dietary supplement is better in case you are allergic to any ingredient.

Comparing the money-back guarantee, we found that Ocusil offers a 60-day money-back guarantee only. On this parameter, Sight Care is better as it is covered with a 180-day money-back guarantee.

Overall, both Ocusil and Sight Care can help you maintain healthy eyes. You can make your decision after talking to your physician.

Vision20 is another dietary supplement that supports healthy vision. The supplement fights free radicals and promotes night vision.

Comparing the ingredients of both supplements, we found that they are more or less similar. Except for a few ingredients, that is. Also, both Vision20 and Sight Care are manufactured in an FDA-approved and GMP-certified facility.

Coming to the pricing of Vision20, we found that it is cheaper than Sight Care. People living in the United States can purchase Vision20 for $59 only.

Both the supplements are manufactured by doctors. However, Vision20 is manufactured by Zenith Lab whereas, Sight Care does not mention anything like that. This gives Vision20 more credibility if we test their brands.

Another common thing between Vision20 and Sight Care is that both offer a 180-day money-back guarantee which is a great thing but makes it really impossible to choose one brand between the two.

Again, you can select the supplement based on ingredients. But we think Sight Care will be a good choice because it brings multiple health benefits in comparison to Vision20.

Place your order right here for the best prices available!

First and foremost, SightCare is designed for anyone between the ages of 19 and 90. If you find yourself struggling with vision impairment, whether due to age-related macular degeneration or other eye-related issues, SightCare might just be your solution. Its specifically formulated to combat various eye health problems, making it a versatile option for a wide range of people.

But what exactly can SightCare help with? The supplement is crafted to address a multitude of eye health issues. If youre battling age-related macular degeneration, glaucoma, cataracts, or even eye infections, SightCare could offer relief. Its a natural, plant-based solution that promotes overall eye health and prevents further damage caused by free radicals and blue light exposure.

Moreover, SightCare doesnt stop at eye health; it promotes your overall well-being. By supporting healthy vision, SightCare indirectly benefits other aspects of your health. For instance, its anti-inflammatory properties protect not only your eyes but also your liver and brain, enhancing your overall vitality.

So, if youre tired of fumbling for glasses or struggling with poor eyesight, SightCare might be your ticket to clear vision. Its natural ingredients, coupled with a 180-day money-back guarantee, offer you a risk-free opportunity to experience the potential benefits.

Getting a healthy vision has become affordable and if you have made up your mind to buy SightCare vision supplement to tackle age-related eye diseases or vision impairment, let us tell you about the pricing structure of the supplement.

You can buy SightCare vision supplement in the following range of bundles from the official website:

Basic Bundle: The basic bundle consists of one bottle of SightCare. You can purchase it for $69.

Popular Bundle: The popular bundle consists of three bottles of Sight Care. It will cost you $177.

Best Value Bundle: The price of this six-bottle bundle is $294.

The Basic bundle will come with a standard shipping charge. So, your total charge will change on this order accordingly. However, for the Popular and Best Value bundles free shipping is available.

Order SightCare today and be glad you did!

The makers will not leave you hanging once you have purchased the Sight Care Formula or have placed an order. You can visit customer support (getSightCare.com) if you have any questions about the order, ingredients, or anything. Their team will be available to guide you and answer all your questions.

This is one of the most frequently asked questions and for all the right reasons. No one wants to make a risky purchase and lose their money over something that will not help them get a crystal clear vision.

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SightCare Reviews - Legit Ingredients or Negative Scam Complaints ... - Seattle Weekly

Is Fasting the Secret to a Longer Life? – Men’s Health UK

Youre probably familiar with the idea, not always concrete, that fasting precipitates good health. Maybe youve been tempted to give the

Game-changing research has proven that short diets that mimic the act of fasting can trigger powerful natural healing and regenerative processes lying dormant in our bodies. Processes that not only burn fat but also fight heart disease, slow ageing, lower cholesterol, reboot the immune system and extend lifespan.

It doesnt stop there: the most recent studies have shown that fasting can kill forms of human cancer in mice and enhance the effects of chemotherapy. In some trials, fasting itself proved as effective as chemotherapy. In short, science is telling us that going hungry could prevent and treat some of the biggest killers of men.

The man behind this research and the structured, prescriptive diet that Im following is Dr Valter Longo. A professor of gerontology at the University of Southern California, he embarked upon this line of inquiry when he first noticed that yeast cells simple organisms that predate humans by millions of years respond to periods of fasting by protecting cells and fighting toxins. Yeast that had been fed a low-calorie diet, Longo discovered, lived up to 10 times longer than the control group.

Longos latest findings show that humans have similar self-healing mechanisms buried deep in our DNA and that periodically fasting on low-calorie diets has a wholesale regenerative effect on the body. Some of the reasons behind this are understood; others remain a mystery. It is believed that fasting kills cancer cells by starving them of glycogen (on which they depend for fuel more than regular cells), thus tricking them into releasing damaging free radicals that spark cellular suicide.

But fastings more general healing powers derive from a different mechanism. Longo has shown that fasting triggers the creation of new stem cells, which repair the body by regenerating tissues, organs and blood, and re-booting the immune system. It sounds too good to be true, I tell Longo when I call him at his California lab. Well, the regeneration that fasting triggers is remarkable, he says. During abstention, organs like the liver, as well as the entire immune system, shrink because they are deemed less necessary. When the body rebuilds these systems, however, it activates the release of healthy stem cells which regenerate newer, younger, more functional versions.

Its akin to pressing the reset button on your bodys operating system, he says. The rebuilding is so massive its probably the closest humans can get to the original embryogenesis process the growth of an embryo during weeks one to eight of human development, he reveals. This is not just a proliferation of new cells but a very coordinated one. It is an evolved programme that has been around for billions of years because organisms starved all the time. For the earliest Homo sapiens, devoid of Smeg fridges and Tesco, periods of feast and famine were the norm. All we need to do, maintains Longo, is rediscover this primitive state of being.

Theres a catch. Its not merely a case of not eating for five days. You have to severely restrict calories, yes, but Longos research shows that those you do eat must have the right balance of nutrients to trigger a natural process called autophagy, which encourages your body to cannibalise waste cell debris. Think of it as your own natural recycling process, removing damaged cells that could cause disease or ill health. Crucially, autophagy also shuts down the enzyme PKA the absence of which has been linked to extended lifespan and the proliferation of healthy stem cells and decreases the hormone IGF-1, which is associated with ageing and cancer risk.

Longos findings could well enrich our lives, but not before they enrich the coffers of L-Nutra, a specially established spin-off company of the University of Southern California. Together with L-Nutra, Professor Longo has developed ProLon: the pre-packaged, off the (pharmacists) shelf Fasting Mimicking and Enhancing Diet (FMED). This five-day menu of all-natural soups, nut bars and snacks provides enough calories to minimise cravings (at least theoretically) without jeopardising the miracles apparently brought about by abstinence. ProLon works by cheating your body into thinking youre literally starving, even though youre just hungry.

Day one is 1090 calories (10 per cent protein, 56 per cent fat, 34 per cent carbs), with days two to five dropping to 725 calories (9 per cent protein, 44 per cent fat and 47 per cent carbs). The first priority when designing the food was that it had to mimic fasting, explains Longo. The food is 20 years of painstaking work: removing, adding, substituting. If I add that ingredient, will it interfere with the PKA effect? Will this one affect the IGF-1 changes? Hunger is also an issue so we tried to make people feel relatively full.

Human trials of ProLon are ongoing, but L-Nutra expects to be able to launch the FMED kits imminently, priced at around 150 for a five-day pack. The healthier among us will be advised to undergo a course of FMED every four months or so, while obese people might benefit from a monthly cycle.

In the name of science, journalism and a little bit of weight management thrown in, I ask Professor Longo to send me a five-day course of ProLon. A mere 48 hours later I am tucking into the contents of my first little white box. The packets within look like space food but taste better than expected. The minestrone soup is watery yet filling, and the choco-crisp bar a surprising treat. Another pack contains olives, which I hate, so I throw them away. I am evidently not starving.

Day two is a different matter. Hunger haunts me all day. I eat my soup with a teaspoon to make it feel more substantial. It doesnt work. I want to stop but Longos words echo around my head: The regeneration of cells and the autophagy only start in days three, four and five, he says. Thats when you push the system to an extreme and back.

My trip to the newsagent on day three almost derails my efforts entirely. When, by the evening, my symptoms have still not subsided, I decide to contact Longo again. What I am experiencing is not only natural but beneficial, I am assured. Our brains are energy-sapping organs that normally run on 100 per cent glucose. But while fasting, our livers produces the ketone body B-hydroxybutyrate, a kind of emergency energy source for the mind, saving energy derived from fat and muscle for other organs.

At this stage in the fast your brain switches to the ketone body utilisation mode, possibly for the first time in your life, says Longo. This can cause a mild headache. I mention my own brain feels like its at the business end of a pneumatic drill, but this is batted away with yet more good news: studies have shown that ketones fight inflammation associated with type 2 diabetes, MS and Alzheimers. To the converted, there is apparently no end to fastings list of fortunes.

Not everyone is similarly convinced, however. Professor Kieran Clarke, from University of Oxfords Department of Physiology, Anatomy and Genetics, thinks fasting could be a smokescreen for the real message. A lot of the benefits [of fasting] relate to extending life, and its possible, but we dont know if its the fasting per se that achieves that, he says. It could just be related to the benefits of helping people reach normal bodyweight. If you look at the records, healthy people invariably do not fast.

Dr Tim Woodman, medical director at Bupa UK, goes further. He believes that fasting could actually have reverse health effects. Losing weight too quickly means that you also tend to lose muscle and water, he says. As a result, your body starts to work more slowly and needs fewer calories to function. So when you resume eating normally, the extra calories will be stored as fat.

One of the most vocal opponents to fasting being seen as a magic bullet is Dr Joel Fuhrman, author of The End of Dieting and Super Immunity. Fuhrman is the man behind so-called nutritarianism, the theory that the key to longevity lies in maximising the number of micronutrients per calorie consumed. Fasting, he holds, is a mere distraction. The modern diet is so nutrient-poor that to discuss fasting without framing it within a normal diet is inappropriate. Our diets are too deficient in micronutrients, phytochemicals and antioxidants to maintain normal immune system function.

If you want to live longer and healthier, says Fuhrman, forget fasting: just eat raw greens; a 30g portion of walnuts; chia seeds and flax seeds; a dish containing mushrooms, beans and onions; plus three portions of fruit like cherries, plums and oranges every single day. A nutritarian diet is the most effective way to not get heart disease, cancer or dementia, and to push the envelope of human longevity closer to 100 years old, he says.

Oh, and ditch the meat. The real impediment to our lifespan, claims Fuhrman, is animal protein. It may be essential for building muscle, burning fat, maintaining a healthy metabolism and supplying a range of important vitamins, but in Fuhrmans eyes it ultimately does your immune system no favours. Huge studies following people for 15-24 years prove that eating more animal products causes cancer, heart disease and shorter lifespans, he says. There is no controversy here. All nutritional scientists agree.

Indeed, the World Health Organisation has recently added red and processed meats to its list of carcinogens. These studies are not new some date back to 2010 but such is our cultural fascination with increasing our protein intake that weve just been ignoring them.

I advocate up to 10 per cent of your diet from animal products, with the other 90 per cent from plants, says Fuhrman. A few days of fasting wont help unless you change you regular diet, too. Animal protein elevates IGF-1, which speeds up the ageing process and negatively affects lifespan. Yes, calorific restriction might briefly restrict IGF-1, but if you then eat a lot of animal products after, it wont actually drop. If you both restrict animal protein and eat a more vegan diet, however, you get the benefits of fasting without actually having to fast.

To eat or not to eat? It would have been naive to expect a clear-cut consensus on such a radical concept. But the arguments made by Fuhrman and Longo arent too dissimilar. Fuhrman acknowledges that fasting is effective; he just takes issue with best practice when temporary abstainers start eating again. And in spite of cases made by critics of fasting, the research into its potential is still compelling.

An extensive review in Research in Complementary Medicine concluded that there was large empirical and observational evidence that medically supervised modified fasting combats high blood pressure, diabetes and obesity. This is simply too significant to ignore.

Were never going to say that fasting is so effective that it means people can smoke and eat badly as soon as they stop, says Professor Longo. The fact is if somebody has a vegan, low-protein diet, a BMI of 23, and regularly exercises, then they will benefit from fasting, just not as much as someone who is unhealthy.

Following an undeniably difficult midpoint, day four of my own experiment is something of an epiphany. I experience a surge of mental energy owing, I am told, to an increase in the levels of noradrenaline and dopamine in my brain. On the first two to three days of your fast you tend to sleep a lot, explains Raimund Wilhelmi of the famous German fasting clinic Buchinger Wilhelmi. Then, like a phoenix, you rise, and after four or five days you feel very positive.

Unfortunately my final rise is less phoenix-like, more vodbull hangover. Day five is tough. With mixed feelings I note that I have lost 1.7kg in just five days not the main purpose of the fast, but also not insignificant. On day six, with the fast finally over, the Toffee Crisps Ive been fantasising about are back on the menu, but my cravings have faded. My appetite has changed, as has my appreciation of portions and flavours. What I can say with some conviction is that fasting will rewire your mind.

There is yet some way to go. Professor Longo believes we are only just beginning to understand the potential power of fasting. Think about this, he says. If you are a 50-year-old man, you have a new child, and that baby is born perfect, it proves your cells know exactly how to build perfection again. How do they know? And is it possible that this can be done within an organism itself, without having to generate a new one? Longo sounds excited, verging on giddy. That is what we are chasing here.

More:
Is Fasting the Secret to a Longer Life? - Men's Health UK