What is Bone Marrow Aspirate Concentrate (BMAC) in Stem Cell Therapy?
Dr. McKenna explains bone marrow aspirate concentrate (BMAC). BMAC contains stem cells and growth factors that can build blood supply and heal tissue. For more information: http://www.rmiclinic.com...
By: Riordan-McKenna Institute
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What is Bone Marrow Aspirate Concentrate (BMAC) in Stem Cell Therapy? - Video
Ryan Benton Discusses Stem Cell Therapy for Duchenne #39;s Muscular Dystrophy
Ryan Benton is the first patient in the United States to receive human umbilical cord-derived mesenchymal stem cell therapy for Duchenne #39;s muscular dystrophy. The US FDA granted Ryan this...
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Ryan Benton Discusses Stem Cell Therapy for Duchenne's Muscular Dystrophy - Video
Stem Cell Therapy for Liver Failure Cirrhosis Kidney Damage - 6 Months After Stemcell Transplant
Bruce from Perth Australia give us an update 6 Months After his cord Mesenchymal stem cell treatment for Iiver cirrhosis, kidney complications in Thailand: More here: http://stemcellthailand.org/th...
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Stem Cell Therapy for Liver Failure Cirrhosis Kidney Damage - 6 Months After Stemcell Transplant - Video
Since the inception of stem cell research, controversy has unfortunately dominated much of the debate without properly considering the potential benefit it may bring to humanity.
Stem cell research involves the manipulation and transfer of undesignated cells in hopes of regenerating other body cells that have been affected by general degeneration. This includes organ failure, tissue damage and even specific ailments like cancer, diabetes and Parkinsons disease. A stem cell may be used to create additional cells for skin, bone, liver, muscle, fat and even nerves. They are all crucial to the development and maintenance of the human bodys immune system.
This research also occasionally utilizes cells from human embryoswhich is where most of the moral debate stems from. Critics of stem cell research typically condemn the practice for ethical reasons. Opponents claim it destroys life and physicians play God in terms of deciding the fate of a lab-grown human embryo.
Without truly lending credence to the wonders of advanced medicine, anti-stem cell critics arent realizing that this research could potentially be Gods work. After all, such procedures unequivocally lead to the extension and increased protection of human life.
Moral obligations aside, the arguments against stem cell research on the basis of embryonic origins have more to do with a misunderstanding of science and less to do with the substantiated concern of saving unborn lives.
Embryonic cells used in stem cell research are typically three to five days old. They are fertilized in vitro within a clinical setting and are provided with consent by the donors.
So say, for instance, a mother with fertility issues utilized eggs from a donor and was over-fertilized. Instead of terminating the remaining pregnancies, the mother could donate the additional eggs to stem cell researchthus saving herself from a difficult and otherwise harmful pregnancyand allow other people who are combating illness to seek a potentially life-saving alternative.
Concerns about how sensitive the embryos may be are also irrelevant, seeing as how those used in stem cell research are only a couple of days old. Fetuses do not fully contain the neurological pathways necessary to feel pain until they are 24 weeks old.
Much like the anti-vaccination movement, many critics against stem cell research are unfortunately misguided on the subject. While the concern is noble, resistance to advances in modern medicine that may ultimately be the deciding factor in how we treat potentially catastrophic diseases isnt a step back from the right direction but an unnecessary fear of moving forward.
Follow Greg Arellano on Twitter @GregGonewild.
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Seattle Genetics, Inc. ( SGEN ) announced the submission of a supplemental biologics license application (BLA) to the FDA for Adcetris as consolidation therapy immediately following an autologous stem cell transplant (ASCT) in patients suffering from Hodgkin lymphoma, who are at a high risk of relapse.
The company submitted the BLA on the basis of positive data from the phase III AETHERA study.
We note that Adcetris is already approved for intravenous injection in the U.S. (accelerated approval) and the EU (conditional marketing authorization) for the treatment of patients with Hodgkin lymphoma after the failure of ASCT or at least two previous multi-agent chemotherapy regimens in patients who have not undergone ASCT.
The drug also received accelerated approval for systemic anaplastic large cell lymphoma (sALCL) after the failure of at least one prior multi-agent chemotherapy regimen in the U.S. and conditional marketing authorization for relapsed or refractory sALCL in the EU.
Adcetris is being developed by Seattle Genetics in partnership with Takeda Pharmaceutical ( TKPYY ). According to the agreement, Seattle Genetics holds the commercialization rights to Adcetris in the U.S. and Canada, while Takeda has the rights in the rest of the world. Both companies share development costs for Adcetris equally, except in Japan where Takeda bears the entire costs of development.
Apart from the AETHERA study, both companies are evaluating Adcetris in three phase III studies - ALCANZA (relapsed cutaneous T-cell lymphoma), ECHELON-1 (front-line advanced classical Hodgkin lymphoma) and ECHELON-2 (front-line mature T-cell lymphoma including sALCL). Data from the ALCANZA study should be out in 2016.
Meanwhile, Seattle Genetics is also working on developing its pipeline beyond Adcetris. The company has several early-stage candidates in its pipeline including six antibody drug conjugates - SGN-CD19A, SGN-CD33A, SGN-LIV1A, SGN-CD70A, ASG-22ME and ASG-15ME. Earlier this week, Seattle Genetics initiated a phase I study on its investigational immuno-oncology agent, SEA-CD40, for multiple types of advanced solid tumors.
Seattle Genetics carries a Zacks Rank #3 (Hold). Some better-ranked stocks in the health care sector are BioMarin Pharmaceutical Inc. ( BMRN ) and Cytokinetics, Inc ( CYTK ). While Cytokinetics carries a Zacks Rank #1 (Strong Buy), BioMarin holds a Zacks Rank #2 (Buy).
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Seattle Genetics (SGEN) Filed Supplemental BLA for Adcetris - Analyst Blog
Fayetteville, Arkansas (PRWEB) February 19, 2015
CardioWise, Inc. has completed development of the first fully integrated version of its Multiparametric Strain Analysis Software (MPSA) and has installed it at the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI). MPSA software is being used in clinical research protocol number 12-H-0078, sponsored by the NHLBI entitled, Preliminary Assessment of Direct Intra-Myocardial Injection of Autologous Bone Marrow-derived Stromal Cells on Patients Undergoing Revascularization for Coronary Artery Disease (CAD) with Depressed Left Ventricular Function. The Principle Investigator is Dr. Keith A. Horvath, the Director of Cardiothoracic Surgery at the NHLBI and Chief of Cardiothoracic Surgery at Suburban Hospital, where he leads the NIH Heart Center. Details of the study are available here: http://clinicalstudies.info.nih.gov/cgi/wais/bold032001.pl?A_12-H-0078.html@mesenchymal@@@@.
The recently completed integrated version of CardioWise analysis software has been installed at the NIH; and, Dr. Justin Miller, and Dr. Ming Li, both research fellows in the Cardiothoracic Surgery Research Program of the NHLBI, have been trained on its operation and use. They were assigned to the project by Dr. Horvath and Dr. Andrew Arai, Chief of the Advanced Cardiovascular Imaging Research Group in the NHLBIs Division of Intramural Research. CardioWise has completed validation testing of its software and the analyses of the first two patient cardiac MRI (CMR) data sets are in process. The patients who enrolled in the protocol received one baseline CMR scan and three additional follow-up CMR scans. Those CMR scans are being analyzed by CardioWise analysis software and the analyses will be compared to determine whether stem cell injections can improve the contractile function of the heart muscle by repairing damaged tissue.
The installation at the NIH under a Beta site agreement signed in 2014 marks the first clinical test of CardioWise MPSA software outside of Washington University School of Medicine in St. Louis, where it was developed. CardioWise has obtained the exclusive worldwide license for the patent-pending software and accompanying normal hearts database from Washington University in St. Louis. The companys MPSA software is uniquely capable of analyzing the three-dimensional motion of the heart that is acquired from cardiac MRI images and then comparing the analysis at 15,300 points to the motion of a normal heart model. The analysis detects portions of the heart that are moving abnormally and demonstrates to what degree the heart muscle has been affected. Since MRI uses no ionizing radiation or contrast, it is completely non-invasive and poses minimal risk to the patient. This allows the patient to be followed through the course of treatment and to measure outcomes of interventions such as the stem cell therapy currently being evaluated. In the near future, CardioWise MPSA may aid doctors to determine what intervention, such as surgery, stent insertion, or drug is most appropriate for the patient who presents with cardiovascular disease symptoms.
CardioWise is commercializing patent-pending, non-invasive Cardiac Magnetic Resonance Imaging (CMR) analysis software that produces a quantified 4D image model of the human heart, called Multiparametric Strain Analysis (MPSA). CardioWise heart analysis software combined with cardiac MRI is a single diagnostic test that is able to provide quantitative analysis of the myocardium, arteries and valves with an unprecedented level of detail. It has the opportunity to become the new gold standard of care for heart health analysis. CardioWise is a VIC Technology Venture Development portfolio company.
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CardioWise Completes Installation of the First Totally Integrated CardioWise Analysis Software at National Institutes ...
Stem Cell Therapy Using Bone Marrow - Howard Beach, Ozone Park, Queens NY - Dr. Benjamin Bieber, MD
http://www.crossbaypmr.com Stem Cell Therapy Using Bone Marrow - Howard Beach, Ozone Park, Queens NY - Dr. Benjamin Bieber, MD - Regenerative Medicine Phone:...
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Stem Cell Therapy Using Bone Marrow - Howard Beach, Ozone Park, Queens NY - Dr. Benjamin Bieber, MD - Video
Jeff Dienhart took a deep breath. Painfully. The tubes from his oxygen tank shifted slightly near his nostrils as he began to speak.
"I was originally diagnosed with cystic fibrosis at the age of 17," Dienhart said matter-of-factly. "At that time, life expectancy for someone with my disease was to live into your early 20s."
At 44, Dienhart, an assistant coach for the Lafayette Central Catholic Knights girls basketball team, long ago beat those odds.
He crouched forward and struggled to take another deep breath, no longer able to hide an illness he used to be embarrassed about.
Central Catholic assistant girls basketball coaches Jeff Dienhart, foreground, and Dave Crandall watch the action as the Knights host Guerin Catholic on Jan. 30. It was the first game for Dienhart in quite a while, as he had spent the better part of the month of January in the hospital. Dienhart is set to receive stem cell treatment in the Dominican Republic to hopefully assist in his battle with cystic fibrosis. (Photo: John Terhune/Journal & Courier)
"Basically, his day is: Wake up, take care of himself and go to basketball," said his son, Drew Dienhart.
The coach has defied other statistics as well. The odds suggest, for example, that many men with cystic fibrosis are infertile, yet Dienhart fathered two children.
Nor are CF sufferers supposed to be able to play marathon rounds of golf.
"I would tell the doctor he played 36 holes of golf in 90-degree heat," said Dienhart's mother, Kathy Dienhart. "The doctor would tell me I made that up. My husband and I came to the conclusion that he is a fighter. Odds don't mean anything to him."
All of which may go some way toward explaining why Dienhart now is preparing to take the riskiest gamble of his life to try to extend his life before the inexorable slow-motion suffocation of cystic fibrosis finally takes its toll.
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Coach gambles on unproven stem cell therapy
San Diego Stem Cell Treatment Center - American Health Journal
Dr. Peter Hanson explains how The San Diego Stem Cell Treatment Center uses the patient #39;s own adult stem cells to research and provide alternative treatment ...
By: San Diego Stem Cell Treatment Center, Inc.
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San Diego Stem Cell Treatment Center - American Health Journal - Video
Any hockey fan would recognize Mr. Hockey Gordie Howe and remember the former Red Wing star as one of the toughest players in the history of the game. His name is famously, if somewhat incorrectly, connected to the unofficial Gordie Howe Hat Trick, in which a player records a goal, an assist, and a fight in the same game. His remarkable career spanned six decades, including a record-setting five in the NHL, and his contributions to the game have lasted long after his retirement.
Struck By Illness
Sadly, Howe suffered a severe stroke in October of 2014. Friends, family, and fans expected the worst. The 86-year-old legends condition seemed to deteriorate rapidly. When he was released to his daughters home in Texas, many people thought Mr. Hockey would not survive long. Then surprising news of significant recovery began to surface. On February 6, Howe made an almost unbelievable public appearance and looked quite well considering what hed been through.
Controversial Treatment
It is now being widely reported that, in December, Howe underwent a stem cell treatment in Mexico. The treatment was developed by San Diego-based Stemedica. Since then, Mr. Hockey has been on the mend. But many experts are questioning whether it was the stem cell treatment, and whether such treatments are safe and reliable. Stem cell treatments are brand new, and many medical professionals believe the results are unproven.
As the debate rages on, the Howe family and many other people in dire medical straits now believe that stem cell treatment can give them hope for meaningful treatment and recovery.
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Stem Cell Treatment for Mr. Hockey Stirs Controversy