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Stem cell research may lead to cure for Type I diabetes …

By Stell Cell Research

DEAR DOCTOR K: My teenage daughter has had Type 1 diabetes since she was 8 years old. Fortunately, exercise, a good diet and insulin treatments have kept her healthy. I recently heard of a breakthrough at Harvard that might someday cure Type 1 diabetes. Can you explain?

DEAR READER: The research youre referring to was conducted in the Harvard laboratory of Dr. Douglas Melton. Like you, Dr. Melton has a child with Type 1 diabetes. When his child became sick, he redirected his laboratory to the goal of finding a cure.

First, some basics. When we eat, sugar (called glucose) gets absorbed into the bloodstream. Almost every cell in our body needs glucose to function normally. However, the cells prefer a steady level of glucose in the blood not too high, not too low, but just right (like Goldilocks).

To keep the glucose level steady, the pancreas a finger-shaped organ in our abdomen makes insulin. Specifically, when we eat and blood levels of glucose rise, cells in the pancreas called beta cells make insulin. Insulin drives glucose from the blood and into cells throughout the body. This lowers blood levels of glucose.

Type 1 diabetes is an autoimmune disease. For reasons that remain unclear, the immune system attacks and kills beta cells. As a result, people with Type 1 diabetes no longer can make their own insulin. Without insulin treatments, blood glucose levels rise dangerously high, and other damaging changes occur in body chemistry.

People with Type 1 diabetes require insulin every day to remain in good health. The discovery of insulin treatment for diabetes (in part by scientists here at Harvard) was a Nobel Prize-winning accomplishment. But it was not a cure. For years, scientists have dreamed of somehow replacing the beta cells that have been killed by the disease.

The discovery of stem cells cells that have the potential to develop into different types of body cells was exciting for medical research. Among other uses, stem cells theoretically can be coaxed into becoming cells that have been killed by disease like beta cells in Type 1 diabetes. However, until now, no one has figured out a technique for transforming stem cells into beta cells, in the large number required to replace the beta cells killed by the disease.

Dr. Meltons team seems to have accomplished that feat. They have been able to create billions of beta cells from one persons stem cells. When the cells were placed inside diabetic mice, they started making insulin in just the right amounts: Blood levels of glucose were not too high, not too low, but just right.

It will be years before we know if this treatment will work in humans. If it works in the short-run, will it continue to work will the cells truly produce a cure?

So while this research does not represent a cure, it is likely to be a landmark event on the road to a cure.

See original here:
Stem cell research may lead to cure for Type I diabetes ...

Alpha Stem Cell Clinics: Delivering a New Kind of Medicine

By Stem Cell Clinic

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Original post:
Alpha Stem Cell Clinics: Delivering a New Kind of Medicine

Minister: Drug administered to Lee Chong Wei by specialist sports clinic

By Stem Cell Clinic

PUTRAJAYA: The banned substance dexamethasone was not administered to Datuk Lee Chong Wei by doctors at the National Sports Institute (ISN) but from a specialist sports clinic as part of a stem cell treatment for his injury.

Youth and Sports Minister Khairy Jamaluddin said it was usual for national athletes to be referred to the Kuala Lumpur-based clinic for specialised treatment such as stem cell procedures.

"There are times when ISN refers our athletes to the private specialist. The doctors at ISN did not administer dexamethasone to the athlete but it was done at the clinic," he said after attending the launch of the GeNexter Carnival 2014 yesterday.

He said the use of dexamethasone was allowed, but only when athletes were "out of competition".

"Many athletes use it outside competition and it usually lasts about 10 days in the system. However, we do not know why it was still in his body," he said.

Chong Wei had reportedly suffered an inner thigh injury and sought stem cell treatment in July.

Last week, Khairy had said that an investigation on the shuttler's medical history revealed that dexamethasone was administered into his body on July 17 to treat his injury.

Chong Wei, 32, pulled out from the Glasgow Commonwealth Games from July 23-Aug 3 to recover from the injury for the Copenhagen World Championships from Aug 25-31.

He was tested positive for dexamethasone during a random doping test at the world meet.

Results of a second test done in Norway had returned positive, resulting in a temporary suspension of Chong Wei pending the outcome of a Badminton World Federation hearing.

Read the original here:
Minister: Drug administered to Lee Chong Wei by specialist sports clinic

Specialist clinic gave Lee banned substance

By Stem Cell Clinic

Putrajaya - The banned substance Dexamethasone was not administered to Malaysian badminton star Lee Chong Wei by doctors at the country's National Sports Institute (ISN), but by a specialist sports clinic in Kuala Lumpur as part of stem-cell treatment for an injury.

This was revealed by Youth and Sports Minister Khairy Jamaluddin yesterday.

"Dexamethasone is allowed for athletes seeking treatment for injuries," he told reporters after attending the launch of the GeNexter Carnival 2014 in Putrajaya.

"It usually lasts in the body for 10 days. But, in this case, we are not sure why it lasted longer than that."

He said that it was the ISN that had referred Lee, the world No. 1, to the clinic.

The shuttler took to Twitter on Saturday, posting a link to an interview in which he describes himself as "devastated" by the allegations.

"Thank you for having faith in me. I never cheated nor will I rely on banned substances," the 32-year-old wrote in the post. "There are so many unanswered questions and I hope to clear my name soon."

Lee - who is facing a suspension of up to two years, which could mean the end of his career - is awaiting a hearing by the Badminton World Federation (BWF). No date has been set.

Referring to the BWF hearing, Mr Khairy said that preparations are being made, with updates to be given in due course.

Lee tested positive for dexamethasone during a random doping test at the World Championships in Copenhagen in August.

Original post:
Specialist clinic gave Lee banned substance

Stem cell therapy for sidelined star Smoko

By Uncategorized

Magnifisio dashed home strongly over 1400m to win Saturdays Lee-Steere Stakes at Ascot. Picture: Westernracepix

Sprinter Smoko will have stem cell therapy at Murdoch Veterinary Hospital to a strained suspensory ligament in his off-foreleg.

Vets found Smoko had strained the ligament when he pulled up sore following his shock sixth as a $2 favourite to Shining Knight in last Tuesday's Colonel Reeves Stakes (1100m) at Ascot.

Co-trainer Ross Price said Smoko would be sidelined for months.

"He will go to Murdoch where they will look at him and see about stem cell therapy," he said.

"In about 10 days we will take him up there and see what they can do. It is then going to be five months off and hoping."

Smoko was a $6.50 chance in Saturday week's Winterbottom Stakes (1200m) before he was scratched. WA's hopes of winning back the Group 1 weight-for-age hinge on Magnifisio, Shining Knight and Testamezzo, with Barakey in doubt after struggling to recover from a virus.

"He is still feeling flat and I will have to wait and see if he improves over the next few days," trainer Jim Taylor said.

Magnifisio firmed from $12 into $8 on the TAB yesterday following her strong win at her debut over 1400m in Saturday's Group 2 Lee-Steere Stakes at Ascot.

Melbourne sprinters Angelic Light, Moment Of Change and reigning champion Buffering dominate betting at $4.30, $6.50 and $7.50.

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Stem cell therapy for sidelined star Smoko

Family's desperate bet on a diabetes cure

By Uncategorized

The day Olivia Cox was diagnosed with Type 1 diabetes at age 16, her mother vowed to find a cure.

"I said to her, "there's someone walking this Earth who has been cured of diabetes, and I'm going to find him," Ruth Cox said.

Cox's search started with a call to Harvard University and ended with a family trip to Lima, Peru. It was at a clinic there that now 18-year-old Olivia and her father, Jeff, 54, who also has diabetes, received an infusion of stem cells designed to wipe out diabetes in their bodies or, at the very least, lessen its impact. The treatment illegal in the United States cost $70,000 for both father and daughter. Two months later, the Niskayuna family is waiting for a transformation and wondering if, in their desperation for a cure, they were snookered by false promises.

Because stem cells can be programmed to become anything from heart muscle to toenails, stem cell therapy can hypothetically be used to treat anything, from baldness to Lou Gehrig's Disease. But the study of regenerative medicine is still nascent in the United States, where it is restricted to procedures that use the patient's own cells, and it has been primarily used in treating cancer a procedure that saved Ruth Cox 13 years ago, when she had breast cancer.

Stem cell treatment using donor cells is more common elsewhere in the world, but with varying results and none that could be described as a cure. An executive order from President Barack Obama opened up funding for stem cell research and there are now more than 4,000 clinical trials under way, some on animals and some recruiting people with various ailments.

The American Diabetes Association strongly supports stem cell research, according to a statement posted on its website, which reads in part:

"Scientists from across the United States and throughout the world, including those involved with the American Diabetes Association believe that stem cell research, especially embryonic stem cell research, holds great promise in the search for a cure and better treatments for diabetes."

Jeff Cox, diagnosed with Type 1 diabetes when he was 11, has suffered none of the complications that often come with the disease neuropathy, loss of vision and heart disease. But Cox said living with diabetes is hell. He pricks his finger at least a dozen times a day to check his blood sugar level, because it is a more precise reading than the glucose monitor he wears. He also wears a pump that he programs to inject him with insulin automatically based on his diet and exercise each day. All the therapies used to treat diabetes are designed to intervene where the pancreas has gone awry.

In Type 1 diabetes, the pancreas doesn't produce insulin due to an autoimmune attack against the beta cell that produces insulin the hormone that converts glucose into energy our bodies need to survive. The Coxes didn't want their daughter to face a lifetime of managing her diabetes. They wanted a cure, and they were willing to take a risk to find it.

In order to treat diabetes with stem cell therapy, pancreatic stem cells isolated from umbilical cord blood that are programmed to produce insulin, plus autologous mesenchymal stem cells from the patient's bone marrow, are injected. Once in the pancreas, the cells are supposed to replicate themselves, gradually replacing the non-insulin producing cells in the host's pancreas. The treatment is conducted in Peru, China, Russia and India and elsewhere, but Zubin Master, a bioethicist at Albany Medical College, said the risks of traveling abroad for stem cell therapy range from paying for an expensive treatment that doesn't work, to cancer and death.

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Family's desperate bet on a diabetes cure

Production of human motor neurons from stem cells is gaining speed

By Uncategorized

PUBLIC RELEASE DATE:

10-Nov-2014

Contact: Ccile Martinat CMARTINAT@istem.fr 33-603-855-477 INSERM (Institut national de la sant et de la recherche mdicale) @inserm

This news release is available in French.

The motor neurons that innervate muscle fibres are essential for motor activity. Their degeneration in many diseases causes paralysis and often death among patients. Researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem - Inserm/AFM/UEVE), in collaboration with CNRS and Paris Descartes University, have recently developed a new approach to better control the differentiation of human pluripotent stem cells, and thus produce different populations of motor neurons from these cells in only 14 days. This discovery, published in Nature Biotechnology, will make it possible to expand the production process for these neurons, leading to more rapid progress in understanding diseases of the motor system, such as infantile spinal amyotrophy or amyotrophic lateral sclerosis (ALS).

Human pluripotent stem cells have the ability to give rise to every cell in the body. To understand and control their potential for differentiation in vitro is to offer unprecedented opportunities for regenerative medicine and for advancing the study of physiopathological mechanisms and the quest for therapeutic strategies. However, the development and realisation of these clinical applications is often limited by the inability to obtain specialised cells such as motor neurons from human pluripotent stem cells in an efficient and targeted manner. This inefficiency is partly due to a poor understanding of the molecular mechanisms controlling the differentiation of these cells.

Inserm researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem - Inserm/French Muscular Dystrophy Association [AFM]/University of vry Val d'Essonne [UEVE]), in collaboration with CNRS and Paris-Descartes University, have developed an innovative approach to study the differentiation of human stem cells and thus produce many types of cells in an optimal manner.

"The targeted differentiation of human pluripotent stem cells is often a long and rather inefficient process. This is the case when obtaining motor neurons, although these are affected in many diseases. Today, we obtain these neurons with our approach in only 14 days, nearly twice as fast as before, and with a homogeneity rarely achieved," explains Ccile Martinat, an Inserm Research Fellow at I-Stem.

To achieve this result, the researchers studied the interactions between some molecules that control embryonic development. These studies have made it possible to both better understand the mechanisms governing the generation of these neurons during development, and develop an optimal "recipe" for producing them efficiently and rapidly.

"We are now able to produce and hence study different populations of neurons affected to various degrees in diseases that cause the degeneration of motor neurons. We plan to study why some neurons are affected and why others are preserved," adds Stphane Nedelec, an Inserm researcher in Ccile Martinat's team.

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Production of human motor neurons from stem cells is gaining speed

Nadal to Receive Stem Cell Treatment for Back Pain – ABC News

By Stem Cell Treatment

Rafael Nadal's doctor says the 14-time Grand Slam winner will receive stem cell treatment on his ailing back.

Angel Ruiz-Cotorro told The Associated Press by phone on Monday that "we are going to put cells in a joint in his spine" next week in Barcelona.

The Spanish tennis star was already sidelined for the rest of the season after having his appendix removed last week.

Ruiz-Cotorro, who has worked as a doctor for Nadal for the past 14 years, said Nadal's back pain is "typical of tennis" players and that the treatment is meant to help repair his cartilage and is similar to stem cell treatment Nadal received on his knee last year.

He said Nadal is expected to return to training in early December.

Several NFL players and baseball players have received stem cell treatment. Nadal's fellow Spaniard Pau Gasol, center of the Chicago Bulls, received stem cell treatment on his knee in 2013.

Nadal experienced severe back pain during the final of the Australian Open in January when he lost to Stanislas Wawrinka.

"(Nadal) has a problem typical in tennis with a back joint, he had it at the Australian Open, and we have decided to treat it with stem cells," Ruiz-Cotorro said.

He said that stem cells were recently extracted from Nadal for a cultivation process to "produce the necessary quantities."

"When we have them we will put them in the point of pain," he said, with the goal of "regenerating cartilage, in the midterm, and producing an anti-inflammatory effect."

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Nadal to Receive Stem Cell Treatment for Back Pain - ABC News

Rafael Nadal to receive stem cell treatment for back pain

By Stem Cell Treatment

Updated NOV 10, 2014 8:59p ET

BARCELONA, Spain

Rafael Nadal's doctor says the 14-time Grand Slam winner will receive stem cell treatment on his ailing back.

Angel Ruiz-Cotorro told The Associated Press by phone on Monday that "we are going to put cells in a joint in his spine" next week in Barcelona.

The Spanish tennis star was already sidelined for the rest of the season after having his appendix removed last week.

Ruiz-Cotorro, who has worked as a doctor for Nadal for the past 14 years, said Nadal's back pain is "typical of tennis" players and that the treatment is meant to help repair his cartilage and is similar to stem cell treatment Nadal received on his knee last year.

He said Nadal is expected to return to training in early December.

Several NFL players and baseball players have received stem cell treatment. Nadal's fellow Spaniard Pau Gasol, center of the Chicago Bulls, received stem cell treatment on his knee in 2013.

Nadal experienced severe back pain during the final of the Australian Open in January when he lost to Stanislas Wawrinka.

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Rafael Nadal to receive stem cell treatment for back pain

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