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Case Study: Stem Cells vs Coronary Artery Bypass Surgery in a Patient with Multi-Vessel Disease 6 Year Follow Up

By Stem Cell Treatment

Case Study: Stem Cells vs Coronary Artery Bypass Surgery in a Patient with Multi-Vessel Disease 6 Year Follow Up

Stem cells outperform heart bypass surgery. A heart patient treated with his own stem cells instead of undergoing coronary bypass surgery is exceeding all expectations 6 years after his adult stem cell treatment.

In 2008, Howie Lindeman, then 58 years old, was facing open heart bypass surgery for three blocked coronary arteries. Lindeman, now 64, had his first heart attack at age 39 that severely damaged his heart. He went through multiple procedures over the last several years including having several stents placed in his blocked arteries. When he developed almost constant chest pain and struggled to walk just 25 feet his doctors decided to perform another heart catheterization. They found severe disease; two arteries were 100% blocked and the remaining one was at 80%. Cardiac bypass surgery was immediately recommended.

Lindeman was not quite ready to have his chest cracked open, so he sought alternative options. He was aware of successful treatments for single blocked arteries with stem cells. Determined to avoid surgery he inquired as to the possibility of stem cell treatment for his condition. Dr. Zannos Grekos, a cardiologist with Regenocyte, agreed to treat him as a case study with the understanding that if the treatment was not successful bypass surgery was his only option. Lindeman was treated with his own stem cells in March of 2008. Within one week of the stem cell procedure Lindeman was feeling much better and returned to fulltime work. His subsequent cardiac testing showed continued improvement up to one year later and now 6 years after his procedure he has had no further cardiac events, his heart tests have remained stable and he continues to work fulltime as a sound engineer touring the world.

I have a high stress, high energy job that I absolutely love, says Lindeman. The treatment has allowed me to continue my career and enjoy the active lifestyle I thought I had lost for good. Im a new person and I continue to feel better every day. Click here to see a video of Howie Lindeman.

The Regenocyte treatment is an outpatient procedure and after a period of observation, the patients then are typically discharged from the hospital. The patient is followed up regularly with testing to monitor their progress and measure their results. Lindemans follow up nuclear cardiac stress testing show a greater than 100% improvement in exercise capacity and improved myocardial perfusion. A heart catheterization performed a year after treatment showed a significant increase in heart function and new blood vessels. Lindemans progress was last reported in December 2011.

Dr. Grekos describes how stem cells are extracted from the patient and then processed in a laboratory. The stem cells are then activated and educated to heal the damaged heart. The lab process provides a key step in Regenocytes treatment success, Dr. Grekos explained. The lab extracts the stem cells from the sample and activates them into over a billion cells while educating them to assist the area of the body that needs treatment. These activated stem cells are known as Regenocytes (regenerative cells). The whole process takes about 3 days.

In this ground-breaking treatment, Dr. Zannos Grekos, an interventional cardiologist, inserted a catheter into Lindemans heart. Over the next 20 minutes, adult stem cells were introduced into the damaged part of his heart. The process of tissue repair begins almost immediately.

We continue to see remarkable results from adult stem cell treatment, said Grekos. Successes like those weve seen with Howie are common and show significant promise for diseases in other organs.

Dr. Grekos and the Regenocyte medical team continue to research the impact of adult stem cell therapy on heart disease. For more information on Regenocyte Adult Stem Cell procedures, upcoming seminars, and to see videos featuring Lindeman, visit http://www.regenocyte.com.

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Case Study: Stem Cells vs Coronary Artery Bypass Surgery in a Patient with Multi-Vessel Disease 6 Year Follow Up

Durham family of 11-year-old leukemia patient getting help with medical bills

By Stem Cell Treatment

DURHAM, N.C. -

A lifesaving stem cell transplant for a little boy in Durham was a success but now the family of Nasir Holman is stuck with massive medical bills.

The Holmans teamed up with a national non-profit to raise money for the treatment and to help other transplant patients.

Duke Hospital has become a second home to Tameka Holman and 11-year-old Nasir. The young boy is battling leukemia for the second time in his short life.

"He has been through so much and when you see him, he has a smile that will throw you back," said Tameka Holman. She said his treatment is going well, but it's been a long journey for his family.

"It had got to one point, I prayed that it it would be taken from him and given it to me," she said. "But I had to accept that it's there and I have to roll with the punches."

Doctors performed a stem cell transplant in April, but the family is having a hard time paying the medical bills. Doctors told the Holman family about the Children's Organ Transplant Association, also known as COTA. The nonprofit raises money for transplant related expenses. It hopes to raise $40,000 for the Holmans.

"I was told his treatment is going to be very expensive and the doctor was telling me that I would need support," said Tameka. "Speaking with them it gave me a lot of hope, not to be too worried or too stressed out about trying to pay his hospital bills."

Nasir and his mom have a long way to go before they reach their goal. But they have faith he'll soon be able to leave the hospital and return home.

Visit their website for more information.

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Durham family of 11-year-old leukemia patient getting help with medical bills

Gene Profiling Technique to Accelerate Stem Cell Therapies for Eye Diseases

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Newswise Researchers at the National Institutes of Health have developed a technique that will speed up the production of stem-cell derived tissues. The method simultaneously measures the expression of multiple genes, allowing scientists to quickly characterize cells according to their function and stage of development. The technique will help the researchers in their efforts to use patients skin cells to regenerate retinal pigment epithelium (RPE)a tissue in the back of the eye that is affected in several blinding eye diseases. It will also help the scientists search for drugs for personalized treatments.

Progress in stem cell-based therapies has been limited by our capacity to authenticate cells and tissues, said Kapil Bharti, Ph.D., a Stadtman Investigator in the Unit on Ocular and Stem Cell Translational Research at the National Eye Institute (NEI), a part of NIH. This assay expands that capacity and streamlines the process.

The assay was described in a recent issue of Stem Cells Translational Medicine.

The RPE is a single layer of cells that lies adjacent to the retina, where the light-sensitive photoreceptors commonly called rods and cones are located. The RPE supports photoreceptor function. Several diseases cause the RPE to break down, which in turn leads to the loss of photoreceptors and vision.

The stem cells Dr. Bharti is using to make RPE are induced pluripotent (iPS) stem cells, which are produced by reverting mature cells to an immature state, akin to embryonic stem cells. iPS cells can be derived from a patients skin or blood cells, coaxed into other cell types (such as neurons or muscle), and in theory, re-implanted without causing immune rejection.

To verify the identity of RPE made from iPS cells, scientists use microscopy to ensure the tissue looks like RPE and physiological assays to ensure the tissue behaves like RPE. They also use a technique called quantitative RT-PCR to measure the expression of genes that indicate ongoing cell development and function. For example, expression of the gene SOX2 is much higher in iPS cells than mature RPE.

But quantitative RT-PCR only permits the simultaneous measurement of a few genes per sample. Dr. Bharti teamed up with Marc Ferrer, Ph.D., of NIHs National Center for Advancing Translational Sciences (NCATS) to develop a multiplex assaya method for simultaneously measuring multiple genes per RPE sample in a highly automated fashion. The assay is based on a commercially available platform from the biotech company Affymetrix. In the assay, tiny snippets of DNA tethered to beads are used to capture RNA moleculescreated when genes are expressed by cells in the RPE sample. Once captured, the RNA from distinct genes is labeled with a fluorescent tag.

Starting with cells from a skin biopsy, the researchers generated iPS-derived RPE and then measured the expression of eight genes that are markers of development, function, and disease. They measured RNA levels of each gene one at a time using quantitative RT-PCR and then all genes simultaneously using the multiplex assay. When compared, the results correlated.

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Gene Profiling Technique to Accelerate Stem Cell Therapies for Eye Diseases

PCP questions use of DAP funds in stem cell research

By Stem Cell Treatment

NewsLife: PCP pushes for more studies on stem cell therapy

NewsLife - PCP pushes for more studies on stem cell therapy (Reported By: Dina Paguibitan) - [July 30, 2013] For more news, visit: http://www.ptvnews.ph Download our mobile App. in your Android phones to read daily news updates https://www.dropbox.com/s/qz9q1b2xu8pomoo/PTV_News_Android_03-20-2013.apk Subscribe to our youtube account: http://www.youtube.com/ptvphilippines Like our facebook page: PTV: http://facebook.com/PTVph NEWS@1: http://facebook.com/PTVnewsat1 NEWS@6: http://facebook.com/PTVnewsat6 NEWSLIFE: http://facebook.com/PTVnewslife PTV SPORTS: http://facebook.com/PTV4SPORTS Follow us at Twitter: http://twitter.com/PTVph Follow our livestream at http://ptvnews.ph/index.php/livestreammenu Ustream: http://www.ustream.tv/channel/ptv-livestream Watch us, every Monday to Friday Balitaan - 5:30 am - 7:00 am Good Morning Boss - 7:00 am - 9:00 am News@1 - 1:00 pm - 2:30 pm PTV Sports - 5:00 pm - 6:00 pm News@6 - 6:00 pm - 7:00 pm NewsLife - 9:15 pm - 10:30 pm Saturday: News@1 The Week That Was - 1:00 pm - 2:00 pm PTV Weekend News - 6:00 pm - 7:00 pm Sunday: News@1 Junior Edition - 1:00 pm - 2:00 pm PTV Weekend News - 6:00 pm - 7:00 pm

The Rundown Live #276 Open Lines (Prisoner Exchange Psyop,Freemasons,Stem cells) (6/5/14) On this Thursday edition of The Rundown Live, Kristan and I go over the sponsors, and the site before we open up the lines and get into many topics like, prison exchange psyop, Freemasons, sex in the classroom, pigs & stem cells, call from Julio, and much more. This one is worth checking out! Make sure you like, recommend and subscribe! Links below! http://therundownlive.com/live LIVE M-F 8C/9E http://tunein.com/station/?StationId=206057 DONATE BITCOIN TO #RUNDOWNLIVE bitcoin:1DqaUC81xg8WMsU2udHThkKHHYgDn3PG8H Listen to The Rundown Live today!! Stitcher Radio: http://www.stitcher.com/podcast/the-rundown-live?refid=stpr Smartphone Apps: https://itunes.apple.com/us/app/id393387997?mt=8 https://play.google.com/store/apps/details?id=com.therundownlive.android.therundown&hl=en Facebook: http://fb.com/TheRundownLive http://www.facebook.com/bigpzone https://www.facebook.com/wearechangemilwaukee Twitter: http://twitter.com/RundownLive http://twitter.com/bigpzone Subscribe to "The Awakening" List here: http://bit.ly/TheAwakeningOnFB (2,000+ Truth LIKE Pages)

News to Go is the daily morning newscast of GMA News TV, anchored by Howie Severino and Kara David. It airs Mondays to Fridays at 9:00 AM (PHL Time) on GMA N...

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Elizabeth Graham talks about Stem Cell Research at the 2010 Oregon Right to Life Conference

I am going to show you how to remove and install you Airforce Airgun's valve stem.

See paper by Narimatsu et al. Cell. 2009 Apr 17;137(2):295-307. http://www.cell.com/abstract/S0092-8674%2809%2900201-3 Planar cell polarity (PCP) regulates p...

Katherine Virgo, PhD From the American Cancer Society Shares the Results of the Primary Care Physician and Medical Oncologist Barriers Study.

How does blonde hair stay blonde? Here, Ito and colleagues explain how Wnt signaling synchronizes two populations of stem cells in the hair follicle bulge to...

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PCP questions use of DAP funds in stem cell research

Lung Center defends DAP-funded stem cell program

By Stem Cell Treatment

PCP: Stem cell therapy untested, expensive, and experimental

MANILA - The Lung Center of the Philippines (LCP) defended the P70 million it received as funding from the Disbursement Acceleration Program for a stem cell research project.

LCP Executive Director Jose Luis J. Danguilan admitted receiving P105 million in total allocations from the DAP, which he said was spent wisely. He said P35 million was spent for the LCP's pediatric unit while the rest went to stem cell research.

The stem cell research program was listed as the 15th item in the Department of Budget and Management list. It was named as the LCPs Bio-Regenerative Technology Program.

The project intends to "fund the Bio-Regenerative Program aimed at harnessing stem cell research and technology to reconstruct new healthy cells, replacing cancer or dead cells."

Danguilan said the equipment bought for both the stem cell and pediatric unit programs have other uses.

"To spend the money wisely, it was decided that pieces of equipment needed for the Bioregenerative Program and the Pediatric Unit could also be used by the Department of Pathology and Laboratory, the Department of Thoracic Surgery and Surgery, the Department of Pulmonary Medicine and the Department of Radiology," he said.

He also noted the money was used to purchase equipment and supplies for the LCP Molecular Diagnostics and Cellular Therapeutics Laboratory for research "mainly on dendritic cell vaccine for use in cancer treatment, specifically lung cancer."

"To place things in perspective, the LCP is a tertiary hospital for pulmonary and other chest diseases, and as far as I know, it is the only tertiary pulmonary specialty hospital in the Philippines. As such, it should take the lead, not only in cutting edge treatment but also in advocacies," he added.

On Tuesday, members of the Philippine College of Physicians (PCP) said the priorities of the government when it comes to funding projects under the DAP seem to be misplaced.

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Lung Center defends DAP-funded stem cell program

Experimental stem cell treatment causes woman to grow parts of a nose on her spine

By Stem Cell Treatment

Stem cells are seen as one of modern medicine's most promising magic bullets, but that doesn't mean that we understand them. A paralyzed woman from the US has learned this the hard way, after an experimental treatment caused her to grow a nose-like tumor on her back. The unnamed person took part in a trial whereby stem cells from her nose were applied to her spine in the hope that it could repair the nerve damage that led to her paralysis. Unfortunately, the treatment was unsuccessful and, eight years later, the subject found worsening pain in that same area. When surgeons operated, they found a tumor comprised of nasal tissue that was producing a thick substance that was remarkably close to mucus.

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Experimental stem cell treatment causes woman to grow parts of a nose on her spine

Stranger pays $128Gs for dying woman's treatment

By Stem Cell Doctors

OTTAWA -- She knows he's tall, slender and generous, but she does not know the name of the man who anonymously donated $128,000 so she can receive "life-saving" stem cell treatment in Chicago.

"We just can't believe it. The future is incredible right now," said Stephanie Headley, 47, who uses an oxygen tank due to damaged lungs.

The single mother of four was diagnosed in 2002 with an aggressive form of systemic scleroderma, an autoimmune disease that hardens the skin and organs.

Doctors didn't expect her to survive this long, but she credits a positive outlook and the support from her parents after her marriage fell apart.

Nonetheless, the disease is progressing and Headley was expecting to die sooner than later from heart failure.

Her family launched a fundraising campaign on youcaring.com, titled Please Save Our Mom, two months ago for a stem cell transplant at Northwestern Memorial Hospital.

Headley was stunned when a man delivered a $128,000 bank draft on July 3.

"He's given me my life," said Headley.

"He's saved my kids enormous pain."

She said the man phoned and wanted to stop by with a donation.

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Stranger pays $128Gs for dying woman's treatment

Stranger pays for dying woman's treatment

By Stem Cell Doctors

OTTAWA -- She knows he's tall, slender and generous, but she does not know the name of the man who anonymously donated $128,000 so she can receive "life-saving" stem cell treatment in Chicago.

"We just can't believe it. The future is incredible right now," said Stephanie Headley, 47, who uses an oxygen tank due to damaged lungs.

The single mother of four was diagnosed in 2002 with an aggressive form of systemic scleroderma, an autoimmune disease that hardens the skin and organs.

Doctors didn't expect her to survive this long, but she credits a positive outlook and the support from her parents after her marriage fell apart.

Nonetheless, the disease is progressing and Headley was expecting to die sooner than later from heart failure.

Her family launched a fundraising campaign on youcaring.com, titled Please Save Our Mom, two months ago for a stem cell transplant at Northwestern Memorial Hospital.

Headley was stunned when a man delivered a $128,000 bank draft on July 3.

"He's given me my life," said Headley.

"He's saved my kids enormous pain."

She said the man phoned and wanted to stop by with a donation.

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Stranger pays for dying woman's treatment

Zhichan decoction increases dopaminergic neurons from transplanted NSCs in PD

By Stem Cell Medicine

PUBLIC RELEASE DATE:

15-Jul-2014

Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research

There is an increasing interest in Parkinson's disease (PD) treatment by increasing dopamine content and reducing dopaminergic metabolites in the brain. Xuming Yang, Shanghai Municipal Hospital of Traditional Chinese Medicine, China and his team detected dopamine content and dopaminergic metabolites in the midbrain of PD rats, which were treated by neural stem cell (NSC) transplantation and Zhichan decoction administration, using high-performance liquid chromatography, and determined global optimization of dihydroxyphenylacetic acid and homovanillic acid levels using genetic algorithm. Results showed that NSC transplantation and Zhichan decoction administration increased dihydroxyphenylacetic acid levels up to 10-fold, while NSC transplantation alone resulted in a 3-fold increment. Homovanillic acid levels showed no apparent change. These findings indicate that after NSC transplantation in PD rats, Zhichan decoction can promote differentiation of NSCs into dopaminergic neurons. Related results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).

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Article: " Zhichan decoction induces differentiation of dopaminergic neurons in Parkinson's disease rats after neural stem cell transplantation," by Huifen Shi1, Jie Song2, Xuming Yang3 (1 Department of Neurology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China; 2 Department of Encephalopathy, Liu'an Hospital of Traditional Chinese Medicine, Liu'an, Anhui Province, China; 3 College of Acupuncture and Massage, Shanghai University of Traditional Chinese Medicine, Shanghai, China) Shi HF, Song J, Yang XM. Zhichan decoction induces differentiation of dopaminergic neurons in Parkinson's disease rats after neural stem cell transplantation. Neural Regen Res. 2014;9(9):931-936.

Contact: Meng Zhao

eic@nrren.org

86-138-049-98773

Neural Regeneration Research

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Zhichan decoction increases dopaminergic neurons from transplanted NSCs in PD

BUSM study: Obesity may be impacted by stress

By Stem Cell Medicine

PUBLIC RELEASE DATE:

15-Jul-2014

Contact: Jenny Eriksen Leary jenny.eriksen@bmc.org 617-638-6841 Boston University Medical Center

Using experimental models, researchers at Boston University School of Medicine (BUSM) showed that adenosine, a metabolite released when the body is under stress or during an inflammatory response, stops the process of adipogenesis, when adipose (fat) stem cells differentiate into adult fat cells.

Previous studies have indicated adipogenesis plays a central role in maintaining healthy fat homeostasis by properly storing fat within cells so that it does not accumulate at high levels in the bloodstream. The current findings indicate that the body's response to stress, potentially stopping the production of fat cell development, might be doing more harm than good under conditions of obesity and/or high levels of circulating blood fat.

The process is halted due to a newly identified signaling from an adenosine receptor, the A2b adenosine receptor (A2bAR) to a stem cell factor, known as KLF4, which regulates stem cell maintenance. When A2bAR is expressed, KLF4 level is augmented, leading to inhibition of differentiation of fat stem cells. The correlation between these two factors leads to an interruption of fat cell development, which could result in issues with fat storage within the cells and it getting into the bloodstream.

While the majority of the study was carried out in experimental models, the group also showed that A2bAR activation inhibits adipogenesis in a human primary preadipocyte culture system. Finally, analysis of adipose tissue of obese subjects showed a strong association between A2bAR and KLF4 expression in both subcutaneous (under the skin) and visceral (internal organ) human fat.

"It may seem counterintuitive, but our body needs fat tissue in order to function properly, and certain biochemical cellular processes are necessary for this to happen," said Katya Ravid, DSc/PhD, professor of medicine and biochemistry at BUSM and director of the Evans Center for Interdisciplinary Biomedical Research who led the study. "Our study indicates that a dysfunction resulting from stress or inflammation can disrupt the process of fat tissue development, which could have a negative impact on processes dependent on proper fat cell homeostasis."

This study is part of ongoing research interest and investigations by researchers in Ravid's lab examining the differentiation of bone marrow and tissue stem cells and the role of adenosine receptors in this process.

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BUSM study: Obesity may be impacted by stress

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