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Image sensor for analysis of blood samples for early diagnosis of diabetes and Alzheimer's disease

By Stem Cell Medical Center

17 hours ago Fig. 1: Semiconductor image sensor

Professor Kazuaki Sawada and Dr. Takigawa of the National Center for Geriatrics and Gerontology and colleagues at Toyohashi University of Technology have established an easy to use, low-cost, rapid, and high sensitivity semiconductor-imaging based medical diagnostic biosensing system for analyzing blood and urine for early diagnosis of ailments including diabetes and Alzheimer's disease.

The new biosensing technology consists of a semiconductor image sensor ( 'charge coupled device' developed by Toyohashi University of Technology) that is sensitive to extremely small changes in electric potential, and microbeads on which antigen-antibody reactions take place. This technology will enable monitoring and diagnosis of diseases for which specific markers are known using very small volumes of blood or urine. Specifically, this technology has detected amiloid beta-peptide, an agent responsible for Alzheimer's disease.

Contracting a disease leads to expression of proteins specific to the diseases in the blood. This new technology is used for early diagnosis of diseases by using this specific protein as the antigen and a marker that captures the protein as the antibody and checking their antigen-antibody reaction. Conventional protocols used to monitor antibody-antigen reactions employ fluorescent probes and detection of fluorescence with microscopic cameras. This process is time consuming because of the necessity to measure fluorescence from the probes and cannot be used to detect low concentrations of antigens when the fluorescence intensity is too low to detect optically.

With this technology, an antigen-antibody reaction is used as in conventional methods, but fluorescence is not measured. Instead, this method employs a semiconductor image sensor to detect minute changes in electric potential generated during an antigen-antibody reaction.

The semiconductor image sensor [Fig. 1] consists of 128 128 pixels that independently sense minute changes in electric potential. The detection sensitivity of antigen-antibody reactions was significantly increased by using microbeads [Fig. 2]. The figures of merit of this technology are given in Table 1. Multiple diseases can also be simultaneously diagnosed by placing different antibodies on different sensing pixels out of a total of 16,384 pixels (128128).

Implementation of the technology will be tested for daily control of lifestyle diseases such as diabetes and in future the technology will be expanded for the early diagnosis of Alzheimer's and Parkinson' diseases.

Explore further: New technique could benefit Alzheimer's diagnosis

More information: Akiteru Kono et al, "Label free bio image sensor for real time monitoring of potassium ion released from hippocampal slices," Sensors and Actuators B 201, 439443, (2014). dx.doi.org/10.1016/j.snb.2014.04.019

A new recombinant antibody can detect and isolate mesenchymal stem cells (MSCs), a nonembryonic source of stem cells with promising applications in tissue engineering, blood stem cell transplantation, and ...

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Image sensor for analysis of blood samples for early diagnosis of diabetes and Alzheimer's disease

Stemedix Stem Cell Therapy for ALS – Patient Experience: Dr. Robert K., MD – Video

By Stem Cell Treatment


Stemedix Stem Cell Therapy for ALS - Patient Experience: Dr. Robert K., MD
Stemedix treats Dr. Robert K., MD. for ALS (Amyotrophic Lateral Sclerosis). Dr. Robert speaks about his patient experience with Stemedix after receiving Stemedix adipose stem cell treatment....

By: Stemedix

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Stemedix Stem Cell Therapy for ALS - Patient Experience: Dr. Robert K., MD - Video

Stem cell centre proposed for resort

By Stem Cell Treatment

Xia Jie.

Medical entrepreneur Xia Jie, whose company Health 100 owns the largest chain of health clinics in China, plans to open overseas facilities to cater for wealthy clients.

That could result in an investment of about $20 million in a regenerative treatment centre in the resort, making it a Mecca for health tourism and athlete injury rehabilitation.

''We're now negotiating with the local medical teams,'' Mr Xia said yesterday through an interpreter while on a four-day fact-finding mission to Queenstown.

''Health 100 really wants to find beautiful cities around the world to take Chinese patients to and Queenstown is one of them.

''The vision is to bring the very high-end customers to have special treatment which is not carried out elsewhere in the world,'' he said.

Health 100 would invest with existing firms Queenstown Regenerative Medicine (QRM), run by Marcelle Noble, and the Queenstown Skin Institute.

Both have small premises at Remarkables Park in Frankton.

Queenstown Skin Institute director Dr Hans Raetz said Mr Xia had indicated plans for a much larger centre, with sites in Remarkables Park, Jacks Point or the Five Mile development off Frankton Ladies Mile already earmarked.

''The size depends on Mr Xia, but we've been talking between $10 million and $20 million.

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Stem cell centre proposed for resort

Pattaya Mail

By Stem Cell Treatment

The South African Chamber of Commerce offered a glimpse into the world of stem-cell therapy at a seminar in Bangkok.

Don Margolis from Repair Stem Cells Institute in the United States was the featured speaker at the Aug. 20 workshop at the Rembrandt Hotel & Towers, lecturing on the facts and fiction about stem cells.

Margolis stated that stem-cell therapy might become the healing method of the future. Meanwhile, major successes have already been made with cancer or problems with the heart, the lungs, the vocal cords, brain, kidneys, and blood. Unfortunately, there are no significant successes in liver disease or bone disease. In this therapy stem cells are used and for many years is the treatment of choice for various types of cancers, such as leukemia. Either endogenous hematopoietic stem cells or those of a donor (postnatal tissue) can be used for adoptive cell transfer.

Group photo (front seated from left) guest speaker Don Margolis and Ragil Ratnam of Pure Growth Asia. (Standing from left) Antony Brown, Chartering Executive of Light House navigation, Elfi Seitz, executive editor of Pattaya Blatt, Allan Riddel, Linda Reay Amazon Colours and General Manager Eric Hallin.

These multipotent blood stem cells, of which colonies of both white as well as red blood cells were cultivated, had already been discovered in 1963 by the Canadian scientists James Till, Ernest McCulloch and Lou Siminovitch. Some years before the first bone marrow transplant was performed in 1957.

Since the 1990s, many more kinds of stem cells were discovered, isolated and characterized. To date, however, is not sufficiently clear how the different types of stem cells are connected and which biological potential they have. In recent years new discoveries have been made in this area and new and promising fields in medical research have been opened. It is also possible to use stem cells from unborn animals (prenatal tissue), such as sheep, as is done in Germany for the last 70 years. For this, however, the embryo may only be a certain age, because the stem cells usually have a lower rate of division and a more limited differentiation potential. Its also possible to get stem cells from the umbilical cord or bone marrow. Embryonic stem cells are pluripotent, whilst adult stem cells probably have a more limited differentiation potential.

Research work is currently still trying to answer fundamental questions like how these stem cells can be induced into certain cell types to replace damaged tissue in order to replace damaged tissue (cell replacement therapy). Other issues include the migration behavior (migration of the cells to a specific location after successful transplantation) or the formation of cell-protective factors (cytokines, growth factors), which are supposed to preserve existing functional tissue from further decline or even regenerate it (regenerative medicine).

In recent years embryonic stem cells have raised many ethical as well as scientific concerns (embryonic stem cells). Although they can be differentiated in almost all body cells (and thus would be universally applicable), for the time being their use is limited. This is due to their high rate of cell division, which is desirable for the propagation of the cells, but at the same time constitutes an increased risk for the development of malignant tumors.

Still, more than 300 Parkinsons patients have been treated with some success worldwide.

Stem cells from the uterine fluid were isolated just recently. They are mostly cells of epithelial origin that are shed during the development of the fetus. They can be obtained directly from the amniotic fluid and be propagated in vitro.

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Pattaya Mail

Beverly Hills Orthopedic Institute Teams up with Beverly Hills Rejuvenation Center to Offer Comprehensive Anti Aging …

By Stem Cell Medical Center

Beverly Hills, California (PRWEB) September 22, 2014

Beverly Hills Orthopedic Institute has now teamed up with the Beverly Hills Rejuvenation Center to offer patients comprehensive anti aging and stem cell therapies. For those individuals desiring to achieve pain relief and avoid the need for joint replacement or cosmetic surgery, treatments at the practices represent the most modern methods available. Call (310) 247-0466 for more information and scheduling.

At Beverly Hills Orthopedic Institute, Dr. Raj offers extensive experience with stem cell procedures for all types of arthritis, sports injuries, fractures, tendonitis and ligament injuries. Frequently, patients are able to delay or avoid the need for joint replacement surgery with the outpatient treatments. Dr. Raj is a Double Board Certified Los Angeles orthopedic doctor who has frequently been named one of LA's Top Orthopedists and also serves as an ABC News medical consultant.

By teaming up with Beverly Hills Rejuvenation Center, the cosmetic aspects of regenerative medicine are included. This includes non surgical facelifts, hair restoration, laser hair removal, photofacials and hormone replacement therapy.

Founded in 2005 by the "wellness experts to the stars Dan Holtz and Devin Haman, Beverly Hills Rejuvenation Center has a well-earned reputation as one of the most comprehensive anti-aging and wellness centers in Los Angeles. Beverly Hills Rejuvenation Center has recently been featured in Malibu magazine, on the Hallmark Channels Home and Family program along with the NBC Nightly News.

Regenerative medicine represents a new paradigm for pain relief and cosmetic procedures. The issues at hand are actually corrected as opposed to simply applying a "band aid." The stem cells offer the capability of restoring and regenerating damaged tissue, whether it be cartilage, skin, muscle or tendons.

For more information and scheduling at either the Beverly Hills Orthopedic Institute or Beverly Hills Rejuvenation Center, call (310) 247-0466.

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Beverly Hills Orthopedic Institute Teams up with Beverly Hills Rejuvenation Center to Offer Comprehensive Anti Aging ...

New Treatment May Prevent Diabetes After Pancreatitis Surgery

By Stem Cell Medical Center

New York, NY (PRWEB) September 22, 2014

Video: Preventing Diabetes After Pancreatectomy - Dr. Beth Schrope

NewYork-Presbyterian/Columbia University Medical Center now offers autologous islet cell transplantation, or auto islet surgery, to prevent diabetes in patients who require a total pancreatectomy. The hospital is the first center in the New York metropolitan area to offer this treatment.

Every year, roughly 87,000 people in the United States receive surgical treatment for pancreatitis, a debilitating condition that causes intense abdominal pain and, potentially, diabetes. Pancreatitis can be so painful that, in some cases, patients must have the entire pancreas removed. While surgery relieves pain in 90 percent of cases, patients are left without the ability to produce insulin, causing a difficult-to-treat form of Type 1 diabetes known as brittle diabetes.

In auto islet surgery, the patient's islet cells, which produce hormones that regulate the endocrine system, are extracted from the pancreas after it is removed. The cells are then processed and reinfused into the patients liver. When auto islet surgery is successful, the reinfused cells produce insulin, acting in place of the pancreas to regulate blood sugar.

The most recent findings show that about one third of patients require no insulin therapy after autologous islet transplantation, another third require some insulin therapy after the procedure, and the procedure is unsuccessful in preventing diabetes in the remaining third.

"The goal of pancreatectomy is to relieve pain," says Dr. Beth Schrope, gastrointestinal surgeon and assistant professor of surgery, NewYork-Presbyterian/Columbia University Medical Center, who specializes in the treatment of pancreatitis. Returning to normal activities and living without pain is a tremendous improvement in patients' quality of life. Now with islet transplantation, theres an added bonusthe possible prevention of diabetes."

NewYork-Presbyterian/Columbia University Medical Center is currently accepting patients for auto islet surgery, through a joint effort of NewYork-Presbyterian/Columbia's Pancreas Center and the Stem Cell Processing and Cell Therapy Laboratory of the Department of Pathology. Patients who need a total pancreatectomy for benign diseases (such as chronic pancreatitis) may be eligible for this procedure to avoid Type 1 diabetes.

NewYork-Presbyterian Hospital/Columbia University Medical Center

NewYork-Presbyterian Hospital/Columbia University Medical Center, located in New York City, is one of the leading academic medical centers in the world, comprising the teaching hospital NewYork-Presbyterian and its academic partner, Columbia University College of Physicians and Surgeons. NewYork-Presbyterian/Columbia provides state-of-the-art inpatient, ambulatory and preventive care in all areas of medicine, and is committed to excellence in patient care, research, education and community service. NewYork-Presbyterian Hospital also comprises NewYork-Presbyterian Hospital/Weill Cornell Medical Center, NewYork-Presbyterian/Morgan Stanley Childrens Hospital, NewYork-Presbyterian Hospital/Westchester Division, NewYork-Presbyterian/The Allen Hospital and NewYork-Presbyterian/Lower Manhattan Hospital. The hospital is also closely affiliated with NewYork-Presbyterian/Lawrence Hospital in Bronxville. NewYork-Presbyterian is the #1 hospital in the New York metropolitan area, according to U.S. News & World Report, and consistently named to the magazines Honor Roll of best hospitals in the nation. For more information, visit http://www.nyp.org.

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New Treatment May Prevent Diabetes After Pancreatitis Surgery

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