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Everyday Hero: Littlestown man donates bone marrow stem cells to stranger

By Stem Cell Doctors

A Littlestown resident went through a five-day procedure to give bone marrow stem cells to a man living in France

By Adam Michael

amichael@GameTimePA.com

@goodoletwonames on Twitter

John Sibirtzeff will never meet the man who used his stem cells to heal. He'll never know exactly what his affliction was, and he's OK with that.

A month ago, Sibirtzeff spent five days in Washington D.C. donating bone marrow stem cells that would be used to heal a 69-year-old man living in France.

"I'll never know who the recipient was," he said. "I'll never know if he was American or French, military or non."

When Sibirtzeff, of Littlestown, was in Navy boot camp in 2007, he opted into the C.W. Bill Young Department of Defense Marrow Donor Program. Naval doctors drew a vial of his blood and stored it after identifying his type. In 2011, Sibirtzeff finished his tour of duty, but his name remained on the donor list.

This past January, the program contacted Sibirtzeff requesting that he return for testing, as he was a potential match for a 69-year-old man living in France.

According to the program's website, salutetolife.org, 70 percent of patients are unable to find a match within their families. Sibirtzeff's receiver was among them.

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Everyday Hero: Littlestown man donates bone marrow stem cells to stranger

Yanks notes: CC Sabatbia to throw soon

By Stem Cell Doctors

CC to throw soon

CC Sabathia is planning to resume throwing while standing later this week.

Sabathia, who went on the disabled list May 11 with right knee inflammation, had a cortisone and stem-cell injection in the knee soon after. He has been walking on a low-impact treadmill for several days and throwing from a chair.

"Were just taking it further each day with more and more stuff and trying to see if its going to swell up," Sabathia said Monday. "I have no pain so far, so hopefully start throwing some time this week and go from there."

Sabathia, who said he got some advice from Knicks forward Amare Stoudemire who has had a similar procedure is scheduled to return near the beginning of July.

Teix gets good news

There was some good news on Mark Teixeira (inflamed right wrist) following Monday nights loss.

Joe Girardi said doctors gave "pretty good news" on Teixeira but the manager wouldnt commit on whether the first baseman would return tonight.

Teixeira, who received a cortisone shot in the surgically repaired wrist Saturday after leaving a game with lingering pain, was hoping to see improvement today. If he doesnt, there could be cause for concern.

Beltran progressing

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Yanks notes: CC Sabatbia to throw soon

One Slight Genetic Change Responsible For Blond Hair In Humans

By Stem Cell Medical Center

June 2, 2014

redOrbit Staff & Wire Reports Your Universe Online

A subtle alternation in DNA involving one single-letter change in the genetic code is enough to generate blond hair in men and women, researchers from Howard Hughes Medical Institute and the Stanford University Medical Center report in Sundays edition of the journal Nature Genetics.

According to developmental biology professor Dr. David Kingsley and his colleagues, a molecule essential to stem cell function plays a vital role in determining a persons hair color. Their analysis for the first time explains the molecular basis for one of our most noticeable physical characteristics.

This genetic mutation is the biological mechanism that helps create that [blond] color naturally, Kingsley, who is also an investigator with Howard Hughes Medical Institute, told Karen Weintraub of National Geographic News. This is a great biological example of how traits can be controlled, and what a superficial difference blond hair color really is.

He added that the study also provides new insight into how the human genome works, since this particular mutation does not impact the protein production of any of its 20,000 genes. Rather, it causes regularly darker hair to become blonde through a process Dr. Kingsley likens to a 20 percent turn of the metaphorical thermostat dial regulating a signaling gene located in the skins hair follicles, Weintraub added.

Weve been trying to track down the genetic and molecular basis of naturally occurring traits such as hair and skin pigmentation in fish and humans to get insight into the general principles by which traits evolve, Dr. Kingley said in a statement. Now we find that one of the most crucial signaling molecules in mammalian development also affects hair color.

The signaling gene in question regulates the expression of a gene that encodes KITLG, a protein that is also known as a stem cell factor. It is also involved in the formation of blood, egg, sperm and stem cells, so completely switching it on or off could have disastrous consequences. However, the mutation impacts the amount of KITLG that is expressed in the hair follicles without altering the way its expressed elsewhere in the body.

In order to discover the blond-hair DNA mutation, the study authors examined a part of the genome that had previously been associated with blondness in people from Iceland and the Netherlands, Weintraub explained. They identified the single-letter change responsible for the trait, and then tested what that alternation did by growing human skin cells in a petri dish. The cells demonstrated a reduction in activity in the switch controlling the signaling gene.

Upon introducing the change into normally brown-haired laboratory mice, the researchers observed that the coats of the rodents became significantly lighter. Furthermore, their study demonstrated that noticeable morphological effects can be observed following slight, tissue-specific changes in the expression of genes, as well as emphasizing how difficult it is to clearly link particular DNA changes with specific clinical or phenotypic outcomes.

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One Slight Genetic Change Responsible For Blond Hair In Humans

stem cell therapy – treatment for mr with delayed milestones by dr alok sharma, mumbai, india – Video

By Uncategorized


stem cell therapy - treatment for mr with delayed milestones by dr alok sharma, mumbai, india
after stem cell therapy treatment for mental retardation with delayed milestones by dr alok sharma, mumbai, india. Stem Cell Therapy done date 18/02/2013 Aft...

By: Neurogen Brain and Spine Institute

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stem cell therapy - treatment for mr with delayed milestones by dr alok sharma, mumbai, india - Video

Funding windfall rescues abandoned stem-cell trial

By Stem Cell Treatment

NIBSC/SCIENCE PHOTO LIBRARY

Embryonic stem cells may have the ability to repair damaged tissue.

A landmark stem-cell trial is sputtering back to life two-and-a-half years after it was abandoned by the California company that started it. But it now faces a fresh set of challenges, including a field that is packed with competitors.

The trial aims to test whether cells derived from human embryonic stem cells can help nerves to regrow in cases of spinal-cord injury. It was stopped abruptly in 2011 by Geron of Menlo Park, California (see Nature 479, 459; 2011); the firm said at the time that it wanted to focus on several promising cancer treatments instead. Now, a new company Asterias Biotherapeutics, also of Menlo Park plans to resurrect the trial with a US$14.3-million grant that it received on 29May from the California Institute for Regenerative Medicine (CIRM), the states stem-cell-funding agency.

But the field has moved on since Geron treated its first patient in 2010, and the therapy that Asterias inherited is no longer the only possibility for spinal-cord injury. StemCells, a biotechnology company in Newark, California, has treated 12 patients in a safety study of a different type of stem cell, and it plans to start a more advanced trial this year to test effectiveness. And another entrant to the field, Neuralstem of Germantown, Maryland, received regulatory approval in January 2013 to begin human tests of its stem-cell product.

Gerons human trial was the first approved to use cells derived from human embryonic stem cells. But regulators halted it twice, once citing concerns about the purity and predictability of the cells being implanted, and again after the company reported seeing microscopic cysts in the spinal cords of rats that had been treated in preclinical studies. The worry was that the cysts could be teratomas uncontrolled growths that can form from embryonic stem cells, a feared side effect of treatment. Geron later said that the growths were not teratomas, and the US Food and Drug Administration allowed the trial to proceed. But after injecting the cells into five of the ten intended patients, the company said that it had run out of money for the trial.

Geron founder Michael West and former chief executive Thomas Okarma then formed Asterias, which bought Gerons stem-cell therapy last year. The company plans first to treat three patients with spinal-cord damage in the neck, using a low dose of the stem cells; it will then treat different people with higher doses to see if the therapy can restore any sensation or function in the trunk or limbs.

The five patients previously treated by Geron, whom Asterias continues to track, had cord damage at chest level. On 22May, Asterias reported that none of those five had experienced serious side effects from the treatment or developed immune responses to it.

Researchers say that the continuation of the former Geron trial is important because it uses a type of cell different from the fetus-derived ones used by StemCells and Neuralstem. Geron surgically implanted embryonic stem cells that had been coaxed in vitro to grow into immature myelinated glial cells, which insulate nerve fibres when mature. The other companies are using partially differentiated cells derived from fetal brain tissue, which might produce substances that protect surviving tissue and make new connections in the neural circuitry.

Its very good for the field, because we now have multiple cell lines being tested in very similar populations of patients, and this will help us define what is needed to make this approach work, says Martin Marsala, a neuroscientist at the University of California, San Diego, whose work has shown that Neuralstems cells can develop into working neurons and restore movement to rats with cord injuries in the neck.

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Funding windfall rescues abandoned stem-cell trial

Bury cop needs 15,000 for treatment in USA

By Stem Cell Treatment

Bury cop needs 15,000 for treatment in USA

5:19pm Monday 2nd June 2014 in News By David Thomson, Reporter

A BURY police officer who suffered a devastating brain haemorrhage and stroke three years ago is trying to raise 15,000 to pay for groundbreaking stem cell treatment in America.

Gulf War veteran Joseph Duffy, aged 46, hopes that the procedure in Arizona will radically improve his mobility and help tackle a rare vascular disease which may have been responsible for his illness.

His wife Wendy, friends and relatives, are planning a series of fundraising events while the Bury-based police constable has launched his own online YouGiving page to help him reach his target.

The father-of-three joined the Army in 1986 and served in West Germany and Canada as well as in the Gulf War. He joined Greater Manchester Police in 2000.

Mr Duffy suffered a suspected heart attack in March, 2011, and a brain haemorrhage and stroke just two months later. He spent six weeks in hospital.

Mrs Duffy, aged 42, said: Joseph has severe left side weakness, struggles to walk and has been left with epilepsy. His speech gets a bit slurred when hes tired. He walks with a stick as well as a muscle stimulator, a cuff around his leg which he uses with a remote control to help his movement.

Joseph also suffers from Churgh Strauss syndrome, a rare vascular disease which attacks various parts of his body and which could have been responsible for the brain haemorrhage and stroke.

Mrs Duffy explained: We hope the treatment can be done this year. It involves liposuction and taking stem cells from the fat and putting them back into the body, to areas that have been damaged, to help repair them and to make new pathways for movement and connection.

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Bury cop needs 15,000 for treatment in USA

Subtle change in DNA, protein levels determines blond or brunette tresses, study finds

By Stem Cell Medical Center

PUBLIC RELEASE DATE:

1-Jun-2014

Contact: Krista Conger kristac@stanford.edu 650-725-5371 Stanford University Medical Center

STANFORD, Calif. A molecule critical to stem cell function plays a major role in determining human hair color, according to a study from the Stanford University School of Medicine.

The study describes for the first time the molecular basis for one of our most noticeable traits. It also outlines how tiny DNA changes can reverberate through our genome in ways that may affect evolution, migration and even human history.

"We've been trying to track down the genetic and molecular basis of naturally occurring traits such as hair and skin pigmentation in fish and humans to get insight into the general principles by which traits evolve," said David Kingsley, PhD, professor of developmental biology. "Now we find that one of the most crucial signaling molecules in mammalian development also affects hair color."

Kingsley, who is also a Howard Hughes Medical Institute investigator, is the senior author of the study, which will be published online June 1 in Nature Genetics. Research specialist Catherine Guenther, PhD, is the lead author.

The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor. This change affects how much KITLG is expressed in the hair follicles without changing how it's expressed in the rest of the body. Introducing the change into normally brown-haired laboratory mice yields an animal with a decidedly lighter coat not quite Norma Jeane to Marilyn Monroe, but significant nonetheless.

The study shows that even small, tissue-specific changes in the expression of genes can have noticeable morphological effects. It also emphasizes how difficult it can be to clearly connect specific DNA changes with particular clinical or phenotypic outcomes. In this case, the change is subtle: A single nucleotide called an adenine is replaced by another called a guanine on human chromosome 12. The change occurs over 350,000 nucleotides away from the KITLG gene and only alters the amount of gene expression about 20 percent a relatively tiny blip on a biological scale more often assessed in terms of gene expression being 100 percent "on" or "off."

"What we're seeing is that this regulatory region exercises exquisite control over where, and how much, KITLG expression occurs," said Kingsley. "In this case, it controls hair color. In another situation perhaps under the influence of a different regulatory region it probably controls stem cell division. Dialing up and down the expression of an essential growth factor in this manner could be a common mechanism that underlies many different traits."

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Subtle change in DNA, protein levels determines blond or brunette tresses, study finds

MetroMDs Advanced Regenerative Therapy Set to Counter Aging; Interesting Price-sharing Model to Make Cosmetic …

By Uncategorized

Los Angeles, CA (PRWEB) May 30, 2014

MetroMD Institute of Regenerative Medicine, a clinic that specializes in HGH and stem cell therapy, introduces an advanced cosmetic regeneration therapy that makes use of CO2 Fractional Laser System and highly efficient DOT to cure age-related skin problems, sun tanning, improve texture and laxity.

All within minimum discomfort, the Co2 Fractional Laser treatment helps in: 1.Reversing the appearance of aged and sun-damaged skin 2.Improving texture and elasticity of the skin 3.Smoothing Wrinkles 4.Reducing the acne and other scar marks

What does DOT Therapy Do?

Sun can wreak havoc to sensitive skin. Now, for ones who need to spend hours under the sun and suffer from wrinkles, discoloration, sun-spots, or lack of skin elasticity, or all of the above, the MetroMD DOT Therapy brings in a chance to alleviate individuals from all these problems. Persons with scars resulting from acne or other skin conditions and injuries can also benefit from this procedure.

One can restore skins youthful appearance with the DOT Therapy even within a one-hour sitting at the doctors office, says Dr Alex Martin, MD and the cosmetic regeneration specialist at MetroMD. While the aging process cannot be stopped, with proper care you can maintain your rejuvenated skins appearance for many years!

MetroMDs therapy is FDA approved and helps people feel younger and revitalized again. Patients seeking a cosmetic treatment in MetroMD, however, will have to go through a complete medical examination to ascertain if their body is suitable for the treatment.

Dr. Martin also said that to make the treatment accessible to more men and women, MetroMD have decided to offer the advanced cosmetic skin regeneration therapy at an exciting price. In addition, there are several charitable trusts that MetroMD has collaborated with in making their advanced therapies available to all at incredibly reduced prices!

About MetroMD

MetroMD is a prominent research institute of regenerative medicine based out of Los Angeles. The institute uses the latest medical technologies and has a highly qualified team to treat hundreds of patients who approach them for non-invasive and painless treatment. Involved in the field of cellular therapy for many years, Dr. Martins cosmetic akin and cellular regeneration therapy team renders complete pre and post treatment help.

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MetroMDs Advanced Regenerative Therapy Set to Counter Aging; Interesting Price-sharing Model to Make Cosmetic ...

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