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Saudi- Conference to shed light on latest stem cell applications

By Stem Cell Medicine

(MENAFN - Arab News) The king abdullah international medical research center (kaimrc) recently joined a conference on stem cell research and its application science and medicine the saudi press agency reported.

the conference which was organized by the health affairs at the national guard unveiled the latest discoveries and findings made by researchers at the stem cell and regenerative medicine unit at kaimrc the agency said.

the conference was attended by several experts on stem cell research representing saudi arabia the united states britain france sweden italy australia and new zealand.

ahmed al-askar ceo of kaimrc said stem cell research is a broad topic that sheds light on how to best exploit human cells to treat diseases for certain organs such as the liver kidney or nerves.

he said the current use of stem cells is centered on plantation for the treatment of certain types of leukemia cancer and genetic diseases.

since its inception three years ago the center has transplanted 200 cells following the creation of a program for transplanting stem cells in children and adults he said.

saudi arabia has the sole stem cell donation registry in arab countries compared with 60 cells donation registries globally he said.

'the saudi stem cell donation center is meant to attract potential donors from arab countries" he said. 'we have had 5000 donors so far."

he said some 400 scientists and experts are working at the center while another 40 physicians have been dispatched on scholarships to acquire training and specialization.

al-askar expressed optimism over the future of stem cell use and its contribution to the treatment of a variety of diseases such as diabetes cancer pulmonary and hepatic fibrosis and neurological and cardiovascular disorders.

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Saudi- Conference to shed light on latest stem cell applications

Former Osiris chief to lead Calif. stem cell agency

By Stem Cell Medicine

By Natalie Sherman, The Baltimore Sun

7:30 p.m. EDT, April 30, 2014

A California agency that oversees $3 billion in stem cell research funding Wednesday named former Osiris Therapeutics head C. Randal Mills to replace its outgoing CEO.

Mills, a Bethesda native and Baltimore resident, stepped down in December after almost 10 years at Osiris, citing personal reasons.

The California Institute for Regenerative Medicine's governing board selected Mills from seven finalists after interviews in April, spokesman Kevin McCormack said. He will make $550,000 in his new position and a start date has not been determined, McCormack said.

The agency noted Mills's leadership of Osiris as it commercialized stem cell drug Prochymal in its announcement of his selection. Mills also served on the agency's grant review board for the past five years.

CIRM's current CEO announced his intention to leave in October.

"It is a tremendous honor to be selected to lead the world's largest stem cell institute during such an exciting and pivotal time for the technology," Mills said in a statement. "We are entering a new phase in regenerative medicine, where an increasing number of therapies are heading into clinical trials. It is our mission to do everything possible to accelerate the development of these treatments for the patients who need them."

nsherman@baltsun.com

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Former Osiris chief to lead Calif. stem cell agency

Stem cell therapy regenerates heart muscle damaged from heart attacks in primates

By Uncategorized

Heart cells created from human embryonic stem cells successfully restored damaged heart muscles in monkeys.

The results of the experiment appear in the April 30 advanced online edition of the journal Nature in a paper titled, "Human embryonic-stem cell derived cardiomyocytes regenerate non-human primate hearts."

The findings suggest that the approach should be feasible in humans, the researchers said.

"Before this study, it was not known if it is possible to produce sufficient numbers of these cells and successfully use them to remuscularize damaged hearts in a large animal whose heart size and physiology is similar to that of the human heart," said Dr. Charles Murry, UW professor of pathology and bioengineering, who led the research team that conducted the experiment.

A physician/scientist, Murry directs the UW Center for Cardiovascular Biology and is a UW Medicine pathologist.

Murry said he expected the approach could be ready for clinical trials in humans within four years.

In the study, Murry, along with Dr. Michael Laflamme and other colleagues at the UW Institute for Stem Cell & Regenerative Medicine, experimentally induced controlled myocardial infarctions, a form of heart attack, in anesthetized pigtail macaques.

The infarcts were created by blocking the coronary artery of macaque for 90 minutes, an established model for the study of myocardial infarction in primates.

In humans, myocardial infarctions are typically caused by coronary artery disease. The resulting lack of adequate blood flow can damage heart muscle and other tissues by depriving them of oxygen. Because the infarcted heart muscle does not grow back, myocardial infarction leaves the heart less able to pump blood and often leads to heart failure, a leading cause of cardiovascular death.

The goal of stem cell therapy is to replace the damaged tissue with new heart cells and restore the failing heart to normal function.

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Stem cell therapy regenerates heart muscle damaged from heart attacks in primates

ADULT STEM CELL THERAPY IS AVAILABLE NOW!

By Stem Cell Doctors

ADULT STEM CELL THERAPY IS AVAILABLE NOW!

Australia - New Zealand - Asia & Pacific Rim - China - Italy

watch the latest video here

Our Foundation is a philanthropic (not for profit) charitable organization that will advise un-well people how to get access to Adult Stem Cell Therapy (ASCT). The Foundation will also promote a campaign showing how it is possible to prevent or limit the progression of these degenerative diseases to the general public. Degenerative disease is an uncontrolled escalating world problem that if not controlled has the ability to bankrupt our health systems. Very little is being done to control this epidemic in Degenerative Disease.

The purpose of the Foundation is to show that people suffering from a degenerative disease like Parkinsons, Multiple Sclerosis, Diabetes 1 & 2, Stroke, Alzheimers, Spinal Cord injuries, Liver diseases, Myocardial infarction, (to name a few) can now receive Adult Stem Cell Therapy that may change their quality of life for the better. That there is now HOPE.

The Foundation wants to especially help children suffering from any debilitating or degenerative disease, for example like Cerebral Palsy, Muscular Dystrophy, Autism, Spinal injuries, Cystic fibrosis, ADHD to name a few. Stem cell treatments have progressed in leaps and bounds in these areas and we have state of the art clinics that specialize in these types of child diseases. Children, because they are still growing can usually benefit substantially from an early intervention using stem cell therapies. Just fill out the Application Formfor a experimental transplant and we will be only to happy to advise both the parents or a fund raising group seeking to help a particular child.

The Adult Stem Cell Foundation has also become the Information Centre in Australasia for clinics that have demonstrated they abide by the highest medical standards, and have a proven track record with these therapies.

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ADULT STEM CELL THERAPY IS AVAILABLE NOW!

FAQs [Stem Cell Information] – National Institutes of Health

By Stem Cell Doctors

Why are doctors and scientists so excited about human embryonic stem cells? Stem cells have potential in many different areas of health and medical research. To start with, studying stem cells will help us to understand how they transform into the dazzling array of specialized cells that make us what we are. Some of the most serious medical conditions, such as cancer and birth defects, are due to problems that occur somewhere in this process. A better understanding of normal cell development will allow us to understand and perhaps correct the errors that cause these medical conditions.

Another potential application of stem cells is making cells and tissues for medical therapies. Today, donated organs and tissues are often used to replace those that are diseased or destroyed. Unfortunately, the number of people needing a transplant far exceeds the number of organs available for transplantation. Pluripotent stem cells offer the possibility of a renewable source of replacement cells and tissues to treat a myriad of diseases, conditions, and disabilities including Parkinson's disease, amyotrophic lateral sclerosis, spinal cord injury, burns, heart disease, diabetes, and arthritis.

What will be the best type of stem cell to use for therapy? Pluripotent stem cells, while having great therapeutic potential, face formidable technical challenges. First, scientists must learn how to control their development into all the different types of cells in the body. Second, the cells now available for research are likely to be rejected by a patient's immune system. Another serious consideration is that the idea of using stem cells from human embryos or human fetal tissue troubles many people on ethical grounds.

Until recently, there was little evidence that multipotent adult stem cells could change course and provide the flexibility that researchers need in order to address all the medical diseases and disorders they would like to. New findings in animals, however, suggest that even after a stem cell has begun to specialize, it may be more flexible than previously thought.

There are currently several limitations to using traditional adult stem cells. Although many different kinds of multipotent stem cells have been identified, adult stem cells that could give rise to all cell and tissue types have not yet been found. Adult stem cells are often present in only minute quantities and can therefore be difficult to isolate and purify. There is also evidence that they may not have the same capacity to multiply as embryonic stem cells do. Finally, adult stem cells may contain more DNA abnormalitiescaused by sunlight, toxins, and errors in making more DNA copies during the course of a lifetime. These potential weaknesses might limit the usefulness of adult stem cells.

It is now possible to reprogram adult somatic cells to become like embryonic stem cells (induced pluripotent stem cells, iPSCs) through the introduction of embryonic genes. Thus, a source of cells can be generated that are specific to the donor, thereby increasing the chance of compatibility if such cells were to be used for tissue regeneration. However, like embryonic stem cells, determination of the methods by which iPSCs can be completely and reproducibly committed to appropriate cell lineages is still under investigation. Since they are derived from adult cells, iPSCs may also suffer DNA abnormalities, as described in the previous paragraph.

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FAQs [Stem Cell Information] - National Institutes of Health

Researchers Create Personalized, Disease-Specific Stem Cells

By Stem Cell Medicine

redOrbit Staff & Wire Reports Your Universe Online

Researchers reported on Monday the creation of the first disease-specific line of embryonic stem cells made with a patients own DNA, a major breakthrough in the field of regenerative medicine.

The achievement marks the first time cloning technologies have been used to generate stem cells that are genetically matched to adult patients.

The independent group of scientists, led by experts at the New York Stem Cell Foundation Research Institute (NYSCF), used somatic cell nuclear transfer to successfully clone a skin cell from a 32-year-old woman with type-1 diabetes. Those cells were then turned into insulin-producing cells resembling the beta cells lost in the disease.

In type-1 diabetes, a patients immune system attacks the bodys insulin-producing pancreatic beta cells, leaving the patient unable to adequately regulate blood sugar levels.

The researchers said the insulin-producing cells created in the current study could someday replace cells damaged by type-1 diabetes, something that could provide better treatment or even a cure for the disease.

I am thrilled to say we have accomplished our goal of creating patient-specific stem cells from diabetic patients using somatic cell nuclear transfer, Susan Solomon, CEO and co-founder of NYSCF, said in a recent statement.

I became involved with medical research when my son was diagnosed with type-1 diabetes, and seeing todays results gives me hope that we will one day have a cure for this debilitating disease.

As reported Monday in the journal Nature, the scientists derived embryonic stem cells by adding the nuclei of adult skin cells to unfertilized donor oocytes using a process known as somatic cell nuclear transfer (SCNT). Embryonic stem cells were created from the adult donor with type-1 diabetes and a healthy control.

In 2011, the team reported creating the first embryonic cell line from human skin using nuclear transfer when they made stem cells and insulin-producing beta cells from patients with type-1 diabetes. However, those stem cells were triploid, meaning they had three sets of chromosomes, and therefore could not be used for new therapies.

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Researchers Create Personalized, Disease-Specific Stem Cells

All Things Stem Cell Visual Stem Cell Glossary

By Stem Cell Clinic

Stem cells: Cells that are able to (1) self-renew (can create more stem cells indefinitely) and (2) differentiate into (become) specialized, mature cell types.

Embryonic stem cells: Stem cells that are harvested from a blastocyst. These cells are pluripotent, meaning they can differentiate into cells from all three germ layers.

Embryonic stem cells are isolated from cells in a blastocyst, a very early stage embryo. Once isolated from the blastocyst, these cells form colonies in culture (closely packed groups of cells) and can become cells of the three germ layers, which later make up the adult body.

Adult stem cells (or Somatic Stem Cell): Stem cells that are harvested from tissues in an adult body. These cells are usually multipotent, meaning they can differentiate into cells from some, but not all, of the three germ layers. They are thought to act to repair and regenerate the tissue in which they are found in, but usually they can differentiate into cells of completely different tissue types.

Adult stem cells can be found in a wide variety of tissues throughout the body; shown here are only a few examples.

The Three Germ Layers: These are three different tissue types that exist during development in the embryo and that, together, will later make up the body. These layers include the mesoderm, endoderm, and ectoderm.

The three germ layers form during the gastrula stage of development. The layers are determined by their physical position in the gastrula. This stage follows the zygote and blastocyst stages; the gastrula forms when the embryo is approximately 14-16 days old in humans.

Endoderm: One of the three germ layers. Specifically, this is the inner layer of cells in the embryo and it will develop into lungs, digestive organs, the liver, the pancreas, and other organs.

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All Things Stem Cell Visual Stem Cell Glossary

Emcell | Stem Cell Treatments | Stem Cell Cost | Embryonic …

By Stem Cell Clinic

THE WORLD'S LARGEST CLINICAL EXPERIENCE IN FETAL STEM CELL TRANSPLANTATION FOR VARIOUS DISEASES AND CONDITIONS

Welcome to Cell Therapy Clinic EmCell

Who We Are?

EmCell clinic is a medical center founded in 1994. In all these years, we treated thousands of patients from different countries and performed more than 6,000 transplantations of fetal stem cells. The treatment methods developed and used in the clinic helped to save and prolong our patients' lives, restore different organs and tissues and achieve positive results in treating diseases and conditions that were considered incurable.

EmCell professionals perform fetal stem cell treatment (in vivo), work out indications and contraindications for the treatment of severe acquired and genetic diseases caused by or resulting in cell count reduction. Moreover, our clinic performs treatment for a wide range of conditions, such as aging, climax, infertility, functional disorders of the internal organs and chronic fatigue syndrome.

All the methods of fetal stem cell treatment used at our clinic are its property and protected by the patents of Ukraine, Russia, the USA and other countries. At present, a number of patents on fetal stem cell application for different diseases and conditions treatment are pending in the patent offices of many countries.

BBC documentary called EmCell clinic the "Last Hope Clinic" because we treated and followed-up the most complicated clinical cases from all over the world.

During the years of intensive work, EmCell team won international acclaim in the field of research and clinical application of fetal stem cells. Our achievements were awarded a number of certificates of the international medical congresses and conferences. But the best award for EmCell clinic is successful treatment and recovery of our patients and their words of gratitude.

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Emcell | Stem Cell Treatments | Stem Cell Cost | Embryonic ...

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