Author Archives: admin


Stem Cell Clinic > Articles by: admin

Stem cell treatment, other breakthroughs giving pets longer, healthier lives

By Stem Cell Treatment

(WMC-TV) - More than 60 percent of American households include at least one pet, and for many of us they are more like family than a four-legged friend.

Eight-year-old Sadie suffers from debilitating arthritis. To owners Greg and Marsha James, she is a miracle dog.

"She's my little girl, she's my baby," said owner Marsha. "I didn't know if we could do anything and what we could do, I thought we were gonna lose her."

Last year she could not even walk, but a scientific breakthrough using her own stem cells put the pep back in her step.

"Stem cell is used to treat chronic arthritic conditions," said Dr. Kathy Mitchener, DVM at Angel Care Center for Pets.

Dr. Kathy Mitchener removed a few ounces of fat from Sadie's tummy; a lab extracted the stem cells, which were then re-injected into her trouble spots.

"If there's joint destruction, if there's changes in metabolism then they change themselves and multiply to help address those issues," said Mitchener.

Stem cell treatment proves to be just one of many medical miracles at the Angel Care Cancer Center for Pets in Bartlett.

Take Rylee for example. The 2-year-old golden retriever has an unusual type of lymphoma.

"Riley was very young, and that's very , very frightening to have such a devastating disease," said Mitchener.

View original post here:
Stem cell treatment, other breakthroughs giving pets longer, healthier lives

Painkillers Could Prove Helpful in Stem-Cell Transplants

By Stem Cell Treatment

Inhibition of a prostaglandin with nonsteroidal anti-inflammatory drugs has been found to cause stem cells to leave marrow, where they could be harvested for patients with blood disorders

Tino Soriano/National Geographic Society/Corbis

Aspirin-like drugs could improve the success of stem-cell transplants for patients with blood or bone-marrow disorders, a study suggests. The compounds coax stem cells from bone marrow into the bloodstream where they can be harvested for use in transplantation and they do so with fewer side effects than drugs now in use.

For patients with blood disorders such as leukemia, multiple myeloma or non-Hodgkins lymphoma, transplantation of haematopoietic stem cells precursor cells that reside in the bone marrow and give rise to all types of blood cell can be an effective treatment.

Previous work has shown that prostaglandin E2, or PGE2, a lipid known to regulate multiple bodily reactions including pain, fever and inflammation, also has a role in keeping stem cells in the bone marrow. In the latest study, researchers show that in mice, humans and baboons, inhibition of PGE2 with non-steroidal anti-inflammatory drugs (NSAIDs) causes stem cells to leave the bone marrow.

Releasing the stem cells The team gave baboons and humans an NSAID called meloxicam. They saw a subsequent increase in the numbers of haematopoietic stem cells in the bloodstream.

The researchers think that the departure of stem cells is caused by the disturbance of a group of bone-forming cells called osteoblasts. These cells secrete a protein called osteopontin that hooks the stem cells to the bone marrow. Inhibiting PGE2 would disrupt the production of osteopontin.

At present, doctors use a drug called filgrastim to mobilize haematopoietic stem cells in donors or in patients undergoing autotransplantation (in which they receive their own stem cells). In patients with multiple myeloma or non-Hodgkins lymphoma, however, and in some donors, stem cells dont mobilize well with filgrastim and other drugs in its class. Using NSAIDs such as meloxicam could enhance filgrastims efficacy, says lead author Louis Pelus of the Indiana University School of Medicine in Indianapolis. The study appears in Nature.

Meloxicam also has comparatively few side effects, says Pelus. He and his colleagues found that other NSAIDs, including aspirin and ibuprofen, can also mobilize haematopoietic stem cells, but these drugs can cause gastrointestinal upset in patients. PGE2 controls the secretion of hydrochloric acid in the stomach, and when you block that youve reduced your ability to control acid secretion. Meloxicam doesnt do that as badly as many of the other [drugs] do, he says.

For Charles Craddock, director of the blood and marrow transplant unit at the Queen Elizabeth Hospital in Birmingham, UK, the results might also hold clues about how to mediate the tricky process of getting cells back to the bone marrow once transplanted. If youre beginning to understand what mediates cells moving out, you might be able to understand what mediates cells moving in. If you can make bone marrow more sticky, when you put cells back, you might be able to keep them in.

Follow this link:
Painkillers Could Prove Helpful in Stem-Cell Transplants

First Road Map of Human Sex-Cell Development

By Stem Cell Treatment

A new study marks a step toward stem cell treatment of infertility

Clouds Hill Imaging Ltd./Corbis

The causes of infertility, which affects around 10% of couples, are often unknown, but may in some cases result from the body's inability to produce viable gametes also known as sperm and egg cells. The first study of the development of such 'germ cells' from humans could help scientists to learn how to create them in the laboratory instead.

Even though the reproductive age for humans is around 1545 years old, the precursor cells that go on to produce human eggs or sperm are formed much earlier, when the fertilized egg grows into a tiny ball of cells in the mothers womb. This ball of cells contains pluripotent stem cells blank slates that can be programed into any type of cell in the body and researchers are hoping to use these stem cells to treat various conditions, including infertility.

But little is known about the early developmental stages of human gametes owing to the sensitivity of working with human tissue and most work in this area has been conducted using mice. In a Nature Cell Biology paper today, researchers from the University of California, Los Angeles, trace the development of early germ cells in human fetuses of between 6 to 20 weeks and analyzed when genes were turned on or off.

The DNA within these early germ cells carries 'epigenetic modifications' structural changes that do not affect the DNA sequence itself but do affect the way that genes are expressed. These changes may have accumulated during the parents lives, and need to be erased during the fetal stage. The study found two major events that wipe out, or reprogram, epigenetic modifications. Most of this reprograming happened before 6 weeks, but the authors found a second event that completes the reprograming after 6 weeks.

This is an important and fundamental paper for understanding human germ-line cells and finding the basic information about human germ-cell biology, says reproductive biologist Evelyn Telfer of the University of Edinburgh, UK. The researchers are clearly working in an uncharted area.

The Los Angeles team worked with anonymized samples from aborted fetuses (after consent) from the University of Washington's Birth Defects Research Laboratory in Seattle.

The researchers also observed that 6-week-old germ cells created in the lab do not match a 6-week-old human germ cell, suggesting that there is a blockage in the development of lab cells that scientists are failing to understand.

Next, we need to look at what is missing to coax immature germ cells to become eggs or sperm in the lab. If we have no road map to follow, then we are just guessing. Now we have a snapshot of what these cells should look like, we can start to try and mimic them, says study co-author Amander Clark.

Follow this link:
First Road Map of Human Sex-Cell Development

Stem cell technology to cure spinal cordv injuries introduced in KSA

By Stem Cell Treatment

The Sultan bin Abdulaziz Humanitarian City (SAHC) announced Tuesday its intention to take stem cell transplantation to new heights by using the method to cure spinal cord injuries. The announcement was made by Prince Khaled bin Sultan, chairman of the Sultan bin Abdulaziz Al-Saud Foundation (SAAF), during the international spinal cord injury conference 2014, which kicked off at the SAHC headquarters on Tuesday. The theme of the conference, which ends on Thursday, is Toward a Better Quality of Life. The conference, first introduced in Australia and New Zealand, is being held for the first time in the Middle East. The technology, in collaboration with the US-based University of Miami, will revolutionize the scope of paralysis surgery in the Kingdom, making it a leader in the field. An accord on collaboration between the SAHC and the Miami Project to Cure Paralysis (MPCP), the first center in the US to receive approval from the supervisory board of the Food and Drug Administration for stem cell therapy, was also signed. Prince Khaled said that the transfer of this technology comes amid efforts to help families cope with the life-changing effects of spinal cord injuries. Prince Khaled said many people between the ages of 16 and 22 suffer such debilitating injuries. The MPCP works on several research and rehabilitation programs in the field of spinal cord and traumatic brain injury, he said. The transfer of this technology to the SAHC will make Saudi Arabia one of the first countries in the region to benefit from the revolutionary treatment of spinal cord injury through stem cell research. SAHC Executive President Abdullah Zarah said the conference would address the latest findings of modern science in the field of spinal cord injury and stem cell transplantation. Around 1,500 Saudis are afflicted with spinal cord injuries every year due to accidents. Rizman Hamid, a senior neurology lecturer at University College London, told Arab News that being afflicted with this type of injury is a lifelong condition. Such critical ailments require follow-up, with radiological investigation to optimize bladder function. Patients should undergo regular investigation as a means of detecting potential problems in the bladder, which can lead to kidney damage, he said. He added that another major problem resulting from spinal cord injuries, especially among women, is urinary incontinence, which has severe and adverse effects on patients. This condition can be cured through a procedure known as the transobtruator tape. This is a minimally invasive procedure that has good long-term results, he said. Firas Sirhan, director of the Center of Excellence for Telehealth and Assisted Living (CETAL) at Buckinghamshire New University in Middlesex, England, said that the use of technology and health care practice is becoming more visible in the treatment and management of spinal cord injuries. Telehealth represents an entirely new way of managing injury that does not easily fit within existing health care frameworks, he said. The use of the telehealth model has contributed to empowering patients to become more involved in the self-management of their condition. Telehealth could be an effective tool that contributes to allowing health care professionals, as well as patients, to recognize and identify any changes in medical conditions. He added that the center can assist in developing packages that combine tested clinical service models with assessed technology to present workable telehealth services based on specific needs.

See the original post here:
Stem cell technology to cure spinal cordv injuries introduced in KSA

He mapped the human genome, now he wants to 'cure' aging

By Stem Cell Medicine

Craig Venter, the U.S. scientist who raced the U.S. government to map the human genome over a decade ago and created synthetic life in 2010, is now on a quest to treat age-related disease.

Venter has teamed up with stem cell pioneer Dr Robert Hariri and X Prize Foundation founder Dr Peter Diamandis to form Human Longevity Inc., a company that will use both genomics and stem cell therapies to find treatments that allow aging adults to stay healthy and functional for as long as possible.

Were hoping to make numerous new discoveries in preventive medicine. We think this will have a huge impact on changing the cost of medicine, Venter said on a conference call announcing his latest venture.

The San Diego-based startup company has $70-million in private backing and has already purchased two ultrafast HiSeq X Ten gene sequencing systems from Illumina Inc, a leading manufacturer of DNA sequencing machines, with the option to buy three more.

The company will use that technology to map 40,000 human genomes in a push to build the worlds largest database of human genetic variation. The database will include sequences from the very young through the very old, both diseased and healthy.

This will be one of the largest data studies in the history of science and medicine, Venter told the conference call.

In addition to gathering whole genome data, the company will collect genetic data on the trillions of microbes including bacteria, viruses and fungi living in and on humans.

By better understanding the microbiomes in the gut, in the mouth, on the skin and other sites on the body, the company said it hopes to develop better probiotics as well as better diagnostics and drugs to improve health and wellness.

Along with the microbiome data, Human Longevity Inc. or HLI will collect data on the metabolome the various metabolites, biochemicals and fats in the body in order to get a better picture of the circulating chemicals that contribute to health and affect how drugs work.

The companys initial treatment targets will be some of the toughest age-related diseases: cancer, diabetes and obesity, heart and liver diseases, and dementia.

Here is the original post:
He mapped the human genome, now he wants to 'cure' aging

stem cell therapy treatment for Cerebral Palsy with Mental Retardation by dr alok sharma, mumbai – Video

By Stem Cell Treatment


stem cell therapy treatment for Cerebral Palsy with Mental Retardation by dr alok sharma, mumbai
improvement seen in just 5 daysafter stem cell therapy treatment for Cerebral Palsy with Mental Retardation by dr alok sharma, mumbai, india. Stem Cell Thera...

By: Neurogen Brain and Spine Institute

More:
stem cell therapy treatment for Cerebral Palsy with Mental Retardation by dr alok sharma, mumbai - Video

Local Weather

By Stem Cell Doctors

Jesse Freeman, 71, had stem cells from his bone marrow injected into his heart after he had a cardiac arrest. With his wife Christine, 67

Mike Brooke, Reporter Sunday, March 2, 2014 6:00 PM

A 71-year-old man has become one of the first heart attack victims to receive pioneering stem cell surgery to see if it will help his recovery.

To send a link to this page to a friend, you must be logged in.

On March 12, I will be 72, so the stem cell surgery for me is an early birthday present just to be alive, admits Jesse Freeman.

I was never ill in my life, then one day I was indoors and didnt feel great. I thought it was an infection that started in my jaw, then spread to my chest. I had a shower and drove down to Harold Wood walk-in centre.

I had extremely high blood pressure and they told me I had had a heart attack.

They took me to The London Chest Hospital and I was being operated on within 10 minutes.

The hospital saved my life they removed the blockage and put in a wire mesh stent to keep the artery open.

The doctors asked me while I was in recovery if I would take part in the stem cell trial.

Originally posted here:
Local Weather

Stem.MD | National Regenerative Medical Practice

By Stem Cell Medicine

It's been nothing but 100% improvement.It just continues to get better.Ive been avoiding doing stairways and I have to be real careful climbing in and out of equipment. I find myself being a lot more relaxed, not having the problems, not having the pain. I don't have the swelling in my knees that I used to have and it hasnt been waking me up at night. View my video testimonial here My name is Susan and Im 62 year old I just finished having my second PRP treatment and Im very, very happy with the results I can do all kinds of things I wasn't able to do beforeI believe my knee will continue to get better as the cartilage grows. Thank you! View my video testimonial here

Many thanks to the Stem MD team for giving me the use of my hands back, pain free! Professional, courteous and compassionate, describes this team of caring people. To anyone considering this procedure, I say you will be amazed and thankful at the results.

Lenita Brewer Ansonia, Ohio

Thank you for giving my life and health back. The PRP treatment worked wonders and helped alleviate the pain. I highly recommend the anti-inflammatory diet, Dr. Purita suggested. My body noticed the difference and I lost 35 pounds. I can finally be active again!

Jennica Califf Coconut Creek, Florida

I thought there was no hope for my chronic back pain. I am so thankful I found out about Dr. Purita and stem cells. I have had back pain for over 5 years, debilitating me to do everyday things. Today my pain has gone down 50%. I tell all my friends and family and wish everyone knew about this wonderful treatment. Thank you so much Dr. Purita

It has been 3 months since my mothers procedure to her knees. Now, my mom climbs into the van without any help, before we had to pull her up and assist her. She does not take painkillers anymore, even her recurring bladder infection and Diabetes is well controlled. All my friends and colleagues are super amazed every time I show them a video of my mom dancing. Thank you so much what you have done for my mom it is truly wonderful and I am forever indebted to you.

Malou Aragon-De Veyra Philippines

I came to Dr. Purita on the advice of a friend when I expressed trepidations about cortisone shots or the possibility no matter how remote of a joint replacement. I was a wrestler in high school and college, and this had done no good for my kneed as I aged. I had no expectations, only hope that somehow my knees could be made less fragile by the stem cell therapy my friend described. I had gotten to the point where any down stairs journey or stepping down off a van or public bus was excruciating, to the point that I usually made an exclamation that wasn't fit for public utterance every time I stepped off a bus or a van. My expectations were neutral at best. I had no idea as to how this stem cell therapy would impact my general health whatsoever. I can say without hesitation that the results have been beyond what I could have hoped. My knees are now cooperative to the point that sometimes I take the stairs down just because I can. I have resumed walking the stairs up and down at work, and I can say that I really don't think about anything I want to do where my kneed are involved. I am not quite where I was when I was 20, but 35 is a real thought, my flexibility and agility are restored to a level I could not have imagined. As an additional part of the procedure Dr. Purita also injected stem cell into my left hand, which has been diagnosed with some arthritis. The results are less instantaneously spectacular, but the had continues to improve. I no longer sit in my office while my hand burns with joint pain, my movement and most of my strength are improving daily, and I have a feeling that within a month or so I will have the same level of improvement I have experiences with my knees. Many thanks to the friend who recommended the trip to Dr. Purita's office, and to Dr. Purita and his staff who have put thoughts of joint replacement and the mad merry-go-round of cortisone shots far in the past for me.

Mark Burns Hypoluxo, Florida

Read more:
Stem.MD | National Regenerative Medical Practice

Cell Therapy: Technologies, Markets and Companies-A 2014 Report With 292 Companies Involved in Cell Therapy Profiled

By Stem Cell Medicine

This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice.

Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation.

Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices.

Cell therapy has applications in a large number of disorders. The most important are diseases of the nervous system and cancer which are the topics for separate chapters. Other applications include cardiac disorders (myocardial infarction and heart failure), diabetes mellitus, diseases of bones and joints, genetic disorders, and wounds of the skin and soft tissues.

Regulatory and ethical issues involving cell therapy are important and are discussed. Current political debate on the use of stem cells from embryonic sources (hESCs) is also presented. Safety is an essential consideration of any new therapy and regulations for cell therapy are those for biological preparations.

The cell-based markets was analyzed for 2013, and projected to 2023.The markets are analyzed according to therapeutic categories, technologies and geographical areas. The largest expansion will be in diseases of the central nervous system, cancer and cardiovascular disorders. Skin and soft tissue repair as well as diabetes mellitus will be other major markets.

The number of companies involved in cell therapy has increased remarkably during the past few years. More than 500 companies have been identified to be involved in cell therapy and 292 of these are profiled in part II of the report along with tabulation of 285 alliances. Of these companies, 162 are involved in stem cells. Profiles of 72 academic institutions in the US involved in cell therapy are also included in part II along with their commercial collaborations. The text is supplemented with 56 Tables and 13 Figures. The bibliography contains 1,050 selected references, which are cited in the text.

Key Topics Covered:

Part I: Technologies, Ethics & Regulations

Executive Summary

Read this article:
Cell Therapy: Technologies, Markets and Companies-A 2014 Report With 292 Companies Involved in Cell Therapy Profiled

→←