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Stem cell therapy | Stem cell treatment | Unique Cell …

By Stem Cell Treatment

Prof. Alexander Smikodub

MD Ph.D

Alexander Smikodub jr.

MD Ph.D

Our clinic offers the advanced and patented methods of fetal stem cell treatment for various conditions and diseases. This method of treatment can be found in wikipedia: Stem cell therapy. Fetal stem cells are non-specialized cells that differentiate (turn) into any other cell type of the body that form organs and tissues. Fetal stem cells that we use for treatment have huge potential for growth, differentiation and are not rejected by the patients body, which allows to achieve unique long-term clinical effects.

We have more than 15 years of experience in stem cell therapy and are the leaders of the industry. Most of the methodic used in the clinic are unique and patent protected in many countries including USA. Since 1994 prof. Alexander Smikodub Sr. was the main researcher, doctor and administrator of the clinic. Now his son, Alexander Smikodub Jr. M.D. continues his fathers venture. During these years more than 6500 patients from all over the world received fetal stem cell treatment, resulting in significant improvement of their conditions, and in case of timely contact with us in complete cure of the diseases still considered lethal by most medical institutions.

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Stem cells are the new word in the medical science, possibly the new revolution. Their importance can be compared with antibiotics discovery or the first successful heart transplantation. They are the inner restorative and regenerative reserve of your body, found in blood, fat layer and bone marrow. After injection of a big stem cells doze, impaired tissues are recovered, regeneration speed is increased and overall condition is greatly improved. We use only material from healthy patients, which passes multiple security checks. They are a perfect material for treating a wide variety of neural and physical diseases.

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Stem cell therapy | Stem cell treatment | Unique Cell ...

Stem cell-based treatment for baldness a step closer

By Stem Cell Treatment

As one of the follically-challenged, any new breakthroughs in the area of hair regeneration will generally get my attention. When stem cells first started to gain widespread media attention I, no doubt like many others, thought a full head of hair was just around the corner. But despite numerous developments, years later my dome is still of the chrome variety. Providing the latest cause for cautious optimism, researchers have now developed a way to generate a large number number of hair-follicle-generating stem cells from adult cells.

In what they claim is a world first, researchers from the University of Pennsylvania (UPenn) and the New Jersey Institute of Technology have developed a technique to convert adult human stem cells into epithelial stem cells (EpSCs).

By adding three genes to human skin cells called dermal fibroblasts that live in the dermis layer of the skin and generate connective tissue, a team led by Xiaowei "George" Xu, MD, PhD, at the Perelman School of Medicine was able to convert them into induced pluripotent stem cells (iPSCs). The iPSCs, which have the ability to differentiate into any cell type, were then converted into epithelial stem cells (EpSCs) that are normally found at the bulge of hair follicles.

Through careful control of the timing of delivery of growth factors to the cells, the researchers say they were able to turn over 25 percent of the iPSCs into EpSCs in 18 days. When they then mixed these EpSCs with mouse follicular inductive dermal cells and grafted them onto the skin of immunodeficient mice, functional human epidermis and follicles similar to hair follicles were produced.

"This is the first time anyone has made scalable amounts of epithelial stem cells that are capable of generating the epithelial component of hair follicles, said Xu, who added that these cells have many potential applications, including wound healing, cosmetics, and hair regeneration.

But some hurdles still need to be jumped before I make my first trip to the hairdresser in a decade. Xu points out that when a person loses hair, they lose not only epithelial cells, but also a kind of adult stem cell called dermal papillae. "We have solved one major problem, the epithelial component of the hair follicle. We need to figure out a way to also make new dermal papillae cells, and no one has figured that part out yet."

On a positive note, researchers from the Tokyo University of Science have reported promising results in reconstructing hair follicle germs from adult epithelial stem cells and cultured dermal papilla cells, so even though we haven't rounded the corner yet,it definitely seems to be getting closer.

The teams research is published in the journal Nature Communications.

Source: University of Pennsylvania

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Stem cell-based treatment for baldness a step closer

Despite perfect match, doctors say little Hannah Day is too weak for transplant

By Stem Cell Doctors

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Hannah Day needs a life saving stem-cell transplant. Her family is not a match.

A sad update to the story of four-year-old Hannah Day.

Hannah lives in Victoria and has been in and out of hospital for most of her short life. She has leukemia andandits the second timein as many years that she is battling cancer.

The Day family went public just after Christmas to try and find a stem-cell donor for Hannah. Thousands of people from around the province rallied behind the Day family who finally got their wish, a perfect match.

But doctors say the little girl has gone through too much radiation to successfully have a stem-cell transplant, leaving her family with the choice of palliative care or a risky transplant next month that has a 60 per cent chance of success.

Canada currently has 326,000 people who are already registered as potential stem-cell donors. Hannah is one of 750 Canadians who are currently awaiting a stem-cell transplant.

To become a stem-cell donoryou can fill out a questionnaire onlineif youre between the ages of 17 and 35, and youll be sent a kit in the mail. A swab of your cheeks will reveal if youre a suitable donor. Once identified as a match, donors will undergo one of two procedures. Stem cells can be harvested from bone marrow under general anesthetic, or throughperipheral blood stem cell donation.

Shaw Media, 2014

Amy started with Global BC in June 2011, and loves being part of such an exciting newsroom. She loves social media and is always looking for a good story! You can also catch her on Trending on and BC1.

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Despite perfect match, doctors say little Hannah Day is too weak for transplant

New protein breakthrough brings leukemia cure closer to reality

By Stem Cell Medicine

Washington, Feb 03 : A team of researchers has identified a protein critical to hematopoietic stem cell function and blood formation.

The finding has potential as a new target for treating leukemia because cancer stem cells rely upon the same protein to regulate and sustain their growth.

Principal investigator Tannishtha Reya from the University of California, San Diego School of Medicine, along with her colleagues found that a protein called Lis1 fundamentally regulates asymmetric division of hematopoietic stem cells, assuring that the stem cells correctly differentiate to provide an adequate, sustained supply of new blood cells.

Asymmetric division occurs when a stem cell divides into two daughter cells of unequal inheritance: One daughter differentiates into a permanently specialized cell type while the other remains undifferentiated and capable of further divisions.

"This process is very important for the proper generation of all the cells needed for the development and function of many normal tissues," Reya said. When cells divide, Lis1 controls orientation of the mitotic spindle, an apparatus of subcellular fibers that segregates chromosomes during cell division.

When researchers deleted Lis1 from mouse hematopoietic stem cells, differentiation was radically altered. Asymmetric division increased and accelerated differentiation, resulting in an oversupply of specialized cells and an ever-diminishing reserve of undifferentiated stem cells, which eventually resulted in a bloodless mouse.

Reya said that they found that a large part of the defect in blood formation was due to a failure of stem cells to expand. Instead of undergoing symmetric divisions to generate two stem cell daughters, they predominantly underwent asymmetric division to generate more specialized cells.

As a result, the mice were unable to generate enough stem cells to sustain blood cell production, the researcher said.

Reya said the findings shed new light on the fundamental regulators of cell growth both in normal development and in cancer.

The study was published in the journal Nature Genetics.

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New protein breakthrough brings leukemia cure closer to reality

Progress in stem cell biology: This could change everything about the practice of medicine

By Uncategorized

Editors note: What follows is a guest post. Michael Zhang is an MD-PhD student studying at the University of Louisville School of Medicine. He is one of my go-to experts on matters of cell biology and stem cells. (His bio is below.)

As you may have heard, this week brought striking news in the field of stem cell biology. Researchers from Boston and Japan published two papers in the prestigious journal Nature in which they describe new and easy ways to transform mouse cells back into stem cells. (NPR coverage here.) Make no mistake, this is not mundane science news. This is big.

I follow cell biology because I believe it is the branch of science that will bring the next major advance in modern medicine. Rather than implant a pacemaker, future doctors may inject a solution of sinus node stem cells, and voila, the heart beats normally. Rather than watch a patient with a scarred heart die of heart failure or suffer from medication side effects, future doctors may inject stem cells that replace the non-contracting scar. And the same could happen for kidneys, pancreas, spinal nerves, etc.

When I heard the news, I emailed Michael the link with the following subject line: This is pretty cool, right? He wrote back. What he taught me is worth sharing.

***

Michael Zhang MD-PhD candidate Univ of Louisville

By Michael Zhang:

Japanese and American cell biologists have recently reported dramatic new findings that are likely to upend biological dogma.

For much of the past century, the prevailing consensus held that once animal cells move past the earliest embryonic stages, they are irreversibly committed to specialized roles in the adult brain cells, heart cells, lung cells etc. In the past decade, two Nobel-winning biologists each separately demonstrated that committed specialist cells (aka differentiated cells) could be reprogrammed back to a primordial, embryonic state (aka pluripotent stem cell) that could then morph into any new type of specialized cell.

Now, Professor Obokata and her colleagues describe new methods to induce this reprogramming of specialized cells to (pluripotent) stem cells. Whereas previous methods involved draconian procedures the transfer of entire nuclei between cells, or the transfer of multiple genes Obokatas group found that simply squeezing a terminally differentiated cell, or immersing it in an acidic solution, could induce reprogramming to an embryonic stem cell state.

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Progress in stem cell biology: This could change everything about the practice of medicine

stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india – Video

By Uncategorized


stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india
improvement seen in just 5 days after stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india. Stem Cell Therapy done date 7 ...

By: Neurogen Brain and Spine Institute

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stem cell therapy treatment for traumatic brain injury by dr alok sharma, mumbai, india - Video

TiGenix : reaches major cell therapy milestone with 1000th.

By Uncategorized

REGULATED INFORMATION FEBRUARY 4, 2014

TiGenix reaches major cell therapy milestone with 1000th implant of ChondroCelect

Leuven (BELGIUM) - February 4, 2014 - TiGenix (NYSE Euronext: TIG), a leader in the field of cell therapy, announced today that it reached a major milestone with the performance of the 1000th ChondroCelect implantation for cartilage repair in the knee. ChondroCelect is the first cell therapy that was granted approval by the European Medicines Agency (EMA) as an Advanced Therapy Medicinal Product (ATMP). Today it is routinely used in orthopedic centers of excellence across several European countries.

"A 1000 patients have already benefited from this innovative therapy, further supporting its efficacy and safety profile," said Eduardo Bravo, CEO of TiGenix. "A milestone such as today's is a clear demonstration of how far the cell therapy field has progressed over recent years, and I have no doubt that it is on its way to become a mainstay in clinical practice. We will continue to work towards turning our ChondroCelect franchise into a cash flow positive asset, and to push the clinical development of our pipeline of stem cell programs to a successful conclusion."

About ChondroCelect An innovative treatment, ChondroCelect has been shown to result in long-term durable clinical benefits in patients with recent cartilage lesions. Five-year follow-up data confirm that the therapeutic effect and the clinical benefit of ChondroCelect gained over baseline is maintained up to at least five years after the cartilage repair intervention. In addition, the data confirm that early treatment with ChondroCelect results in a superior clinical benefit over microfracture, and a lower failure rate.

Cartilage lesions of the knee are a frequent cause of disability in the active population. Caused by repetitive microtraumata, or due to sports or traffic accidents, cartilage lesions rarely heal spontaneously. When untreated, they predispose to osteoarthritis, which causes disability and represents a major socioeconomic burden. A treatment that allows symptom relief and functional recovery is key. To meet this important medical need, TiGenix developed ChondroCelect, the first cell therapy that was granted approval by the EMA as an ATMP.

ChondroCelect is administered to patients in an autologous chondrocyte implantation procedure known as Characterized Chondrocyte Implantation. TiGenix has designed a sophisticated manufacturing process to preserve the cells' characteristics and biological activity, and to maintain their ability to produce high quality cartilage. This process meets the highest quality standards and has been approved by the EMA.

For more information: Eduardo Bravo Chief Executive Officer eduardo.bravo@tigenix.com

Claudia D'Augusta Chief Financial Officer claudia.daugusta@tigenix.com

About TiGenix

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TiGenix : reaches major cell therapy milestone with 1000th.

Stem cell treatment: Controversial for humans, but not for pets

By Stem Cell Treatment

PHOENIX, Ariz. -

Stem cell research and therapy on humans has traveled a long and often politically troubled path.

Not so for pets, where stem cell treatment has been used for nearly 10 years and now it is so routine, and so successful, it can be done in a day.

Ava is a 90 pound, 2-year-old Akita, who is about to undergo stem cell surgery. A little IV, a little anesthesia and Ava is out.

"It is used for arthritis mostly," said Dr. Velvet Edwards.

Ava is just beginning her day at Pecan Grove Veterinary Hospital in Tempe. Dr. Edwards oversees the stem cell procedure.

"Stem cells are healing cells, so they seek out area of injury damage or destruction," explained Edwards. "They accelerate healing and help the animal, the patient, the pet just use their own natural abilities to get better."

Veterinary stem cells are harvested from the animal's own fat cells. They are separated and processed by machinery right inside the vet's office and then injected back into the dog's trouble spots.

Thanks to new technology developed by Meti Vet, the process is completed in just a day.

"The pet comes in the morning, it's anesthetized and I collect about two to four grams of fat usually behind the shoulder blade," said Edwards. "Then I hand that fat over to my technicians to run it through a series of steps.. basically to dissolve the fat and get down to a little stem cell pellet... Then we take that pellet and we reconstitute it and make it injectable. I will put it back into the animal's body wherever I need it later that day."

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Stem cell treatment: Controversial for humans, but not for pets

Center for Stem Cell & Regenerative Medicine – UTHealth

By Stem Cell Medical Center

Phone 713.500.3429; Fax 713.500.2424

Brian R. Davis, Ph.D., Associate Professor and DirectorQi Lin Cao, M.D., Associate Professor Charles S. Cox, Jr., M.D., Professor Radbod Darabi, M.D., Ph.D., Assistant ProfessorDong H. Kim, M.D., ProfessorMikhail G. Kolonin, Ph.D., Associate Professor Yong Li, M.D., Ph.D., Associate Professor Ying Liu, M.D., Ph.D., Assistant Professor Nami McCarty, Ph.D., Assistant Professor Naoki Nakayama,Ph.D., Associate Professor Laura A. Smith Callahan,Ph.D., Assistant Professor Pamela L. Wenzel, Ph.D. Assistant Professor Jiaqian Wu, Ph.D., Assistant Professor

About the Center

A major focus of contemporary medicine is the development of effective therapies for the restoration of human tissues and organs lost to diseases and trauma. Regenerative Medicine is a rapidly emerging field that stands at the intersection of a variety of rapidly developing scientific disciplines: stem cell biology, tissue engineering, biomaterials, molecular biology, immunology and transplantation biology and clinical research. Implicit in the successful design, implementation and application of regenerative medicine/tissue engineering approaches to the repair of a damaged tissue or organ is the reliance on the unique biological properties of stem cells.

The mission statement of the Center for Stem Cell and Regenerative Medicine at the IMM is: To study the fundamental properties of stem cells and to translate their unique biological properties into novel cellular therapies for graft engineering and tissue regeneration for currently intractable disorders. While it is therefore implicit that any such program would span basic-translational-clinical research, it is essential that such an endeavour is ultimately underpinned by excellence in fundamental stem cell research. The Director of the Center, Dr. Brian R. Davis is currently in the process of recruiting a multidisciplinary faculty with the appropriate breadth of expertise, innovation and scientific rigour in the discipline of stem cell biology with the dual intention to promote the excellence and innovation of research within the Center and secondly to ensure the quality and appropriateness of stem cell based translational research initiatives emanating from the Center. In addition, the Center is also envisioned as an educational resource, which in the medium to long-term will be the basis for the development of an academic program in stem cell biology on campus. Moreover, by interfacing effectively with other programs and institutions within the UTHSC, the Center will also act as a focus to stimulate the development and implementation of novel cellular therapies for a range of diseases and disorders.

Some of the current areas of research in the Center are highlighted below:

Brian R. Davis, Ph.D. Associate Professor of Molecular Medicine & Director, Center for Stem Cell and Regenerative Medicine Annie and Bob Graham Distinguished Chair in Stem Cell Biology Ph.D. ~ California Institute of Technology / Pasadena, California

Qi Lin Cao,M.D. Associate Professor, The Vivian L. Smith Department of Neurosurgery & Center for Stem Cell and Regenerative Medicine M.D.~ Hunan Medical University / Hunan, China

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Center for Stem Cell & Regenerative Medicine - UTHealth

Stem Cell Medical Research Center

By Stem Cell Medical Center

Functions of organism last properly depending on well organized and controlled reproduction, immigration, differentiation and maturation activities unions. It is possible when the cells in organ and tissues are produced regularly. Stem cells are at the top of this system in an organism. Stem cell is that are able to renew themselves by keeping on splitting for long time by remaining same (not differentiated) and they can differentiate according to needs of organism. Stem cells are major source of cell based treatments. Thus some of researches are using human or animal based stem cells from different kind of tissues.

In different kinds of stem cell researches state that mature stem cell have some significant advantage on the cure of damaged tissues. The advantage of using stem cell obtained from an adult is that stem cell can reproduce in patients own cultivation and then before facing regeneration, they can be given to the patient.

Stem cell researches and its treatments are still the very popular topic in the world

STEM CELLS AND WHY ARE THEY IMPORTANT?

Research of stem cell has gained much prominence in recent years for its therapeutic potential in dealing with diseases many of which are essentially incurable by normal therapies. These diseases are characterized by progressive cell loss which has no regenerative potential: e.g. neurodegenerative process leads to Alzheimer and Parkinson diseases. These have become serious health problems as people in advanced societies now live longer. There is great variability in the occurrence and onset of these diseases and the underlying environmental and genetic factors are unknown. The destruction of the beta cells of pancreatic islets is the main cause of diabetes, another serious health problem, can be caused by autoimmune reactions resulting in cell loss (1).

Stem cells are distinct from other cell types by two important characteristics. First, they are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity (in G0). Second, under certain physiologic or experimental setting, they can be induced to become tissue or organ specific cells with special functions (2). In some organs, stem cells regularly divide to repair and replace worn out or damaged tissues such as the gut and bone marrow. In other organs, however, such as the heart and the pancreas, stem cells only divide under special conditions. They have the remarkable potential to develop into many different cell types in the body during early life and growth. On the other hand, they serve as a sort of internal repair system in many tissues, dividing essentially without limit to replenish other cells as long as the person or animal is still alive (2).

Scientists frequently worked with two kinds of stem cells from animals and humans: embryonic stem cells and non-embryonic somatic or adult stem cells. Researchers discovered ways to derive embryonic stem cells from early mouse embryos nearly 30 years ago, in 1981. In 1998, the detailed study of the biology of mouse stem cells led to the discovery of a method to derive stem cells from human embryos and grow the cells in the laboratory. These cells are called human embryonic stem cells. They are important for living organisms for many reasons. In the 3- to 5-day-old embryo, called a blastocyst, the inner cells give rise to the entire body of the organism, including all of the many specialized cell types and organs such as the heart, lung, skin, sperm, eggs and other tissues. In some adult tissues, such as bone marrow, muscle, and brain, discrete populations of adult stem cells generate replacements for cells that are lost through normal wear and tear, injury, or disease (2,3).

In 2006, researchers made another breakthrough by identifying conditions that would allow some specialized adult cells to be reprogrammed genetically to assume a stem cell-like state. This new type of stem cell was called induced pluripotent stem cells (iPSCs) (2).

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Stem Cell Medical Research Center

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