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Cell Therapy – Technologies, Markets and Companies – Updated 2013 with New Companies and Profiles

By Uncategorized

DUBLIN, July 16, 2013 /PRNewswire/ --

Research and Markets ( http://www.researchandmarkets.com/research/dhdp3r/cell_therapy) has announced the addition of Jain PharmaBiotech's new report "Cell Therapy - Technologies, Markets and Companies" to their offering.

(Logo: http://photos.prnewswire.com/prnh/20130307/600769 )

This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice.

Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation.

Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices.

Cell therapy has applications in a large number of disorders. The most important are diseases of the nervous system and cancer which are the topics for separate chapters. Other applications include cardiac disorders (myocardial infarction and heart failure), diabetes mellitus, diseases of bones and joints, genetic disorders, and wounds of the skin and soft tissues.

Regulatory and ethical issues involving cell therapy are important and are discussed. Current political debate on the use of stem cells from embryonic sources (hESCs) is also presented. Safety is an essential consideration of any new therapy and regulations for cell therapy are those for biological preparations.

The cell-based markets were analyzed for 2012, and projected to 2022. The markets are analyzed according to therapeutic categories, technologies and geographical areas. The largest expansion will be in diseases of the central nervous system, cancer and cardiovascular disorders. Skin and soft tissue repair as well as diabetes mellitus will be other major markets.

The number of companies involved in cell therapy has increased remarkably during the past few years. More than 500 companies have been identified to be involved in cell therapy and 287 of these are profiled in part II of the report along with tabulation of 273 alliances. Of these companies, 158 are involved in stem cells. Profiles of 72 academic institutions in the US involved in cell therapy are also included in part II along with their commercial collaborations. The text is supplemented with 55 Tables and 12 Figures. The bibliography contains 1,050 selected references, which are cited in the text.

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Cell Therapy - Technologies, Markets and Companies - Updated 2013 with New Companies and Profiles

Dr. Leslie Miller Named Chief Science Officer of Okyanos Heart Institute's Cardiac Stem Cell Therapy Treatment for …

By Stem Cell Treatment

Freeport, Bahamas (PRWEB) July 17, 2013

Okyanos Heart Institute, whose mission it is to bring a new standard of care and better quality of life to patients with coronary artery disease using cardiac stem cell therapy, has named Leslie Miller, M.D., F.A.C.C. as its chief science officer. Dr. Miller is a leading heart failure specialist and experienced thought leader in cardiac stem cell therapy. He is director of the University of South Florida (USF) Heart Institute, professor of cardiovascular sciences at the USF Health Morsani College of Medicine, and was formerly the director of cardiology at Georgetown University. Dr. Miller has been an investigator in over 80 clinical trials.

The use of adult stem cells derived from adipose (fat) tissue to treat congestive heart failure has the potential to change the game for the millions of patients suffering from this disease, said Miller. These stem and regenerative cells have been shown to stimulate the growth of new blood vessels, are anti-inflammatory and prevent at-risk cells from dying. These combined mechanisms can provide important therapeutic benefit to heart failure patients.

As a current member of Okyanos medical advisory council, Dr. Miller has actively advised us on patients criteria for cardiac stem cell therapy, says Okyanos Chief Medical Officer Howard Walpole. In this additional role as Chief Science Officer, he will be evaluating new research protocols and reporting on findings from the patient registry that will help advance the field of cardiac stem cell therapy. His experience and track record in leading academic research is outstanding. This integrated approach in research and clinical application in The Bahamas makes Okyanos Heart Institute one of the first places patients can receive new treatments.

Dr. Leslie Miller is a well-respected visionary in the field of cardiovascular disease says Okyanos CEO Matt Feshbach. This role will further advance our quality measures and the structure of our patient registry. We look forward to his contribution to improving the lives of patients using adult stem cells derived from their own fat tissue who, up until now, have exhausted their options with conventional treatments.

ABOUT OKYANOS HEART INSTITUTE: (Oh key AH nos) Based in Freeport, The Bahamas, Okyanos Heart Institutes mission is to bring a new standard of care and a better quality of life to patients with coronary artery disease using cardiac stem cell therapy. Okyanos adheres to U.S. surgical center standards and is led by Chief Medical Officer Howard T. Walpole Jr., M.D., M.B.A., F.A.C.C., F.A.C.A.I. Okyanos Treatment utilizes a unique blend of stem and regenerative cells derived from ones own adipose (fat) tissue. The cells, when placed into the heart via a minimally-invasive catheterization, stimulates the growth of new blood vessels, a process known as angiogenesis. The treatment facilitates blood flow in the heart and supports intake and use of oxygen (as demonstrated in rigorous clinical trials such as the PRECISE trial). The literary name Okyanos (Oceanos) symbolizes flow. For more information, go to http://www.okyanos.com/.

NEW MEDIA CONTENT: Okyanos LinkedIn page: http://www.linkedin.com/company/okyanos-heart-institute

Okyanos Facebook page: https://www.facebook.com/OKYANOS

Okyanos Twitter page: https://twitter.com/#!/OkyanosHeart

END

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Dr. Leslie Miller Named Chief Science Officer of Okyanos Heart Institute's Cardiac Stem Cell Therapy Treatment for ...

Stem Cell Therapy Treatment for Idiopathic Polymyositis by Dr Alok Sharma, Mumbai, India. – Video

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Stem Cell Therapy Treatment for Idiopathic Polymyositis by Dr Alok Sharma, Mumbai, India.
Improvement seen in just 5 day after Stem Cell Therapy Treatment for Idiopathic Polymyositis by Dr Alok Sharma, Mumbai, India. After Stem Cell Therapy 1. Fle...

By: Neurogen Brain and Spine Institute

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Stem Cell Therapy Treatment for Idiopathic Polymyositis by Dr Alok Sharma, Mumbai, India. - Video

Stem Cell Therapy Treatment for Left Hemiplegic Cerebral Palsy by Dr Alok Sharma, Mumbai, India. – Video

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Stem Cell Therapy Treatment for Left Hemiplegic Cerebral Palsy by Dr Alok Sharma, Mumbai, India.
Improvement seen in just 5 day after Stem Cell Therapy Treatment for Left Hemiplegic Cerebral Palsy by Dr Alok Sharma, Mumbai, India. After Stem Cell Therapy...

By: Neurogen Brain and Spine Institute

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Stem Cell Therapy Treatment for Left Hemiplegic Cerebral Palsy by Dr Alok Sharma, Mumbai, India. - Video

Stem Cell Therapy Treatment for Autism by Dr Alok Sharma, Mumbai, India. Part 2 – Video

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Stem Cell Therapy Treatment for Autism by Dr Alok Sharma, Mumbai, India. Part 2
Improvement seen in just 7 months after Stem Cell Therapy Treatment for Autism by Dr Alok Sharma, Mumbai, India. After Stem Cell Therapy 1. Emotional respons...

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Stem Cell Therapy Treatment for Autism by Dr Alok Sharma, Mumbai, India. Part 2 - Video

Stem Cell Therapy Treatment for Cerebral Atrophy by Dr Alok Sharma, Mumbai, India. Part 2 – Video

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Stem Cell Therapy Treatment for Cerebral Atrophy by Dr Alok Sharma, Mumbai, India. Part 2
Improvement seen in just 5 day after Stem Cell Therapy Treatment for Cerebral Atrophy by Dr Alok Sharma, Mumbai, India. After Stem Cell Therapy 1. Ball throw...

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Stem Cell Therapy Treatment for Cerebral Atrophy by Dr Alok Sharma, Mumbai, India. Part 2 - Video

Sanger maps unique route to stem cells

By Stem Cell Treatment

Cambridge researchers have developed a new method to produce stem cells using designed proteins.

Stem cells have the potential to be used to replace dying or damaged cells with healthy cells. This repair could have wide-ranging uses in medicine such as organ replacement, bone replacement and treatment of neurodegenerative diseases. This study brings closer to realising the full potential of stem cell technology.

We have gone down a completely different road to standard practices to produce stem cells from adult cells, says Dr Pentao Liu, senior author from the Wellcome Trust Sanger Institute.

Current techniques to reprogramme cells are inefficient and its imperative to find other ways to create stem cells. We hope that our novel approach to reprogramming cells into stem cells will become a new and safer alternative to current practices.

The team looked at proteins called transcription factors, which regulate the activity of all human genes. Each transcription factor acts to modify the activity of several or many genes.

A key set of these transcription factors are able to convert or reprogramme adult cells into induced pluripotent stem cells or iPS cells. However, these factors also act on many genes other than those involved in reprogramming.

The team developed artificial designer transcription factors to target those key reprogramming genes more accurately, minimising activity on other genes.

"This is a promising and exciting development in our attempt to produce iPS cells that lend themselves in practical applications, says Dr Xuefei Gao, first author from the Wellcome Trust Sanger Institute. We have shown that targeting gene-control regions, called enhancers, in this structured way is a very effective in controlling a gene and reprogramming cells to become iPS cells.

In conventional methods, the transcription factors used to programme cells take part in complicated ways and target many different parts of the genome as they are used to reprogramme the cells to become stems cells. As a result, the throughput of successfully reprogrammed cells can be low and the additional number of steps can have associated risks, such as affecting genes that can influence tumour development.

The designer transcription factors are extremely accurate. Because this method targets key genes directly and avoids additional genetic detours, it reduces the potential risks linked with standard practices.

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Sanger maps unique route to stem cells

Sacramento startup gets FDA approval to sell stem cell therapy products

By Stem Cell Treatment

SynGen Inc., the midtown Sacramento medical device startup that develops stem cell harvesting systems, announced today that it has received U.S. Food and Drug Administration clearance to market three related products to process cord blood.

All three products are related to the company's SynGenX-1000 system, which harvests stem and progenitor cells from units of collected cord blood.

The company says harvested cells can be used for treatment of numerous medical conditions, including leukemia, lymphoma and more than 70 genetic diseases.

"We thank the FDA for guiding us through the ... clearance process. SynGen is dedicated to developing products that consistently exceed our customers' expectations," said Philip Coelho, company president and CEO.

Last year, SynGen received $5 million from San Francisco venture capital firm Bay City Capital LLC to further develop what Coelho has called the next generation in stem cell harvesting systems.

SynGen recently received additional financing of up to $3 million from Bay City.

Noting the new financing, Coelho said "we look forward to providing U.S. cord blood banks with the competitive advantage they will enjoy by using our products."

The Sacramento company also said it has received certification to market products in Europe. SynGen's focus is the development and commercialization of medical systems that harvest stem and progenitor cells from umbilical cord blood, bone marrow, peripheral blood and other tissues.

Coelho is the founder and former CEO of Rancho Cordova-based ThermoGenesis Corp., leaving that company's board of directors in 2008. He co-founded SynGen in 2007.

For more details, see syngeninc.com.

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Sacramento startup gets FDA approval to sell stem cell therapy products

Can stem cells make the blind see again?

By Stem Cell Treatment

Ten patients suffering from retinitis pigmentosa have had their eyesight restoredincluding a woman who had only 17 percent of her vision left By Anne A. Jambora Philippine Daily Inquirer

MANELLE Jose (left) whose vision has been restored. Dr. Harvey Uy is part of a three-man team that tested stem cell therapy for vision restoration in retinis pigmentosa. ROMY HOMILLADA

Making the blind see may no longer be an outrageous feat encountered only in books. What was once labeled a miracle is now the subject of intense study by the scientific community. The key to restoring vision? Why, yes, stem cell therapy, of course.

The stem cell therapy that began in November 2011, while still limited to the cure of the inherited eye disease retinitis pigmentosa (RP), has already restored the eyesight of 10 subjects.

RP is a degenerative disease that has, until today, no known cure. It is the most common inheritable cause for blindness1.5 million people around the world are blind from it.

RP is a group of hereditary eye disorders that affects the retinas ability to respond to light, causing people to slowly lose their vision until they go completely blind.

For most people afflicted with RP, when the slow death of the retinal photoreceptor cells occurs, the peripheral vision gradually darkens until one is left with a tunnel vision. Over time, the tunnel vision becomes smaller until one day everything becomes completely dark, when blindness finally settles in.

The inevitable progress of the disease can begin in a persons teens, such that they become completely blind by the time they reach adulthood.

There is no other more devastating eye disease than retinitis pigmentosa, because they start off life with fairly good vision, said Dr. Harvey S. Uy, vice president of the Philippine Academy of Ophthalmology and research fellow in ophthalmology at the Research and Biotechnology Division of St. Lukes Medical Center.

100,000 Filipinos

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Can stem cells make the blind see again?

How stem cells increase libido and enhance looks

By Stem Cell Treatment

Stem cell therapy results in dramatic decrease in blood sugar, improved sleep, increased energy levels and shoulder mobility, and improved libido. But StemGenics says patients must be tested first if theyre up to it By Marge C. Enriquez Philippine Daily Inquirer

OPERATION room maintains hospital standards.

Sam Fernandez (not his real name), a businessman in his late 50s, who underwent stem cell treatment, excitedly called his doctor, about its immediate effects. Although the benefits were supposed to be visible six to eight weeks after the procedure, the patient felt like a young man again in six days.

His doctor gave him intravenous therapy, directly injecting stem cell on the shoulder to address the chronic pains and the penis for erectile dysfunction. Aside from the dramatic decrease in blood sugar, improved sleep, increased energy levels and shoulder mobility, the patient reported increased libido. He claimed he was getting woody (slang for erection) every day that his wife couldnt keep up with him.

As the age management medicine trend, there are many hospitals and aesthetic centers offering stem cell treatment at the average price of P1.2 to P1.4 million. Accredited by the Department of Health, StemGenics not only offers medical technology that is unique to the clinic but also procedures at a reasonable price range of P500,000.

Repairing tissues

Dr. Eduardo Santos, president of StemGenics, said that stem cell therapy is just one of the three aims of a health program: There is repair, maintain and defend, he said.

He explained: Maintenance is a function of exercise, nutritional supplement and hormone support. Defense is a function of guarding the body against cancer and infection. You boost the immune system. The repair is the stem cell procedure, our anchor service. The stem cell regenerates the tissues. You reintegrate the organs which need to be repaired.

Stem cells used for repair are found in the bone marrow, blood, fat or adipose tissues and in other parts of the body. These cells are stimulated upon getting alerts on injury or inflammation. Their task is to precipitate the healing process when the body is injured. They send proteins to control the inflammation and refresh new cells, and engage new growth proteins. These cells are exchanging regenerative signals within the environment.

After birth, we have 80 to 100 million stem cells, said Santos. Over time, they decrease. By mid-30s, the count is down to 25 million. You wont have enough to heal as fast as you were younger. That is when aging happens. That is why disease associated with aging comes inheart conditions, dementia, decreased function of kidney and liver.

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How stem cells increase libido and enhance looks

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