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Scientists challenge patent ban for embryonic stem cell research

Scientists and lawyers in Britain are challenging a European ban on the patenting of embryonic stem cells which they believe is blocking the development of new treatments for a range of illnesses including diabetes, heart disease and Parkinsons.

They have been joined by a High Court judge who has asked the Court of Justice of the European Union in Luxembourg to clarify its decision to prevent the patenting of stem cell research involving the use and destruction of human embryos. Medical researchers and biotechnology firms are incensed by the European courts ban on stem cell patents. They say it is deterring investment in Europe while scientists in Asia forge ahead with research into new medical treatments based on embryonic stem cells.

Sir Ian Wilmut, who cloned Dolly the sheep, and Professor Austin Smith of the Wellcome Trust Centre for Stem Cell Research at Cambridge University, said that banning patents has effectively removed the protection of intellectual property that is crucial for commercial investment.

Their concerns have now been voiced by Henry Carr QC, a deputy judge of the High Court, who questioned whether the European court really understood the scientific basis of its ban, which it issued last year.

The European court ruled that German scientists could not patent a technique based on human embryonic stem cells because it involved the destruction of something capable of commencing the process of development of a human being in other words a human embryo.

However, Mr Carr said that the definition of a human embryo used by the court may be too broad because it included types of artificially created embryos that are not capable of developing into a foetus.

Stem cells have the potential to revolutionise the treatment of human disease. Because of their capacity to differentiate into almost any type of adult cell, human stem cells open the door to a wide variety of new therapies and other medical applications, Mr Carr said in his judgment on a patent appeal case. However, to exclude [from patentability] processes of development which are incapable of leading to a human being does not, in my view, strike a balance at all It is more akin to a total exclusion from patent protection of the fruits of stem cell research, to the detriment of European industry and public health.

Professor Pete Coffey of University College London, who is conducting one of the first clinical trials of stem cells to treat progressive blindness, said the ban on patenting stem cell research could harm its future development in Britain and Europe. It creates [funding problems for] this kind of translational research taking ideas from the lab into the clinic, he said.

The US Supreme Court ruled yesterday that genes extracted from the human body cannot be patented.

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Scientists challenge patent ban for embryonic stem cell research

Induced Pluripotent Stem Cell Industry (iPSC Market) Report Updated for 2013 Now Available at ReportsnReports.com

Dallas, Texas (PRWEB) June 13, 2013

Sales (number) of iPSC research products worldwide have been growing at a rate of 14.7% per year for the past five years. In addition, 22% of all stem cell researchers now self-report as having used induced pluripotent stem cells within a research project. It is clear that iPSCs are a vital research trend within the scientific community. A distinctive feature of this report is an end-user survey of 293 researchers (181 U.S. / 112 International) that identify as having induced pluripotent stem cells as their core research focus. These survey findings reveal iPSC researcher needs, technical preferences, key factors influencing buying decisions, and more. They can be used to make effective product development decisions, create targeted marketing messages, and produce higher prospect-to-client conversion rates.

Complete 2012-13 Induced Pluripotent Stem Cell Industry Report on market metrics, dynamics, and trends says continued research and experimentation has resulted in numerous advances over the last few years. In one example, the University of Michigan announced in Circulation Research (2012) that they had developed innovative methods for use of induced pluripotent stem cells derived from skin biopsies to create cardiac muscle cells. This accomplishment quickly fueled other research into the use of iPSCs for the reversal and repair of diseased heart tissue. Similar advances will continue to be perfected for use of reprogrammed adult cells in the treatment of other diseases and disorders. Original techniques for iPSC production, such as viral induced transcription processes, are being replaced with newer technologies as private industries join with the scientific community to develop safe and efficient methods of iPSC production. With sustained research and experimentation, established guidelines for effective production of iPSC will be commonplace.

In summary, induced pluripotent stem cells represent a promising tool for use in the reversal and repair of many previously incurable diseases. This is a must-read industry report for research supply companies to optimally position themselves to sell iPSC products. To profit from this lucrative and rapidly expanding market, one needs to understand ones key strengths relative to the competition, intelligently position own products to fill gaps in the market place, and take advantage of the crucial iPSC trends. Claim this report now to profit from this expanding market - Buy / Order a copy of this report @ http://www.reportsnreports.com/Purchase.aspx?name=206575.

Key findings of this report on iPSC market include:

Companies and Research Institutes mentioned / covered in this report:

Commerical entities developing iPSC therapies: ViaCyte, Fate Therapeutic, iPerian, Cellular Dynamics and Mesoblast.

Strategic collaborations for development of iPSC products: Life Technologies, Lonza Group AG, EMD Millipore, Sigma Aldrich, Roslin Cells, Ltd., ArunA Biomedical, CeeTox and Cellular Dynamics.

Top research institutions performing stem cell research: University of Wisconsin, including WARF, WiCell, and the WISC Bank, US National Institutes of Health (NIH), Johns Hopkins University, California Institute for Regenerative Medicine and University of Connecticut Induced Pluripotent Stem Cell Core (iPSCC).

Comprehensive Table of Contents and more on the report Complete 2012-13 Induced Pluripotent Stem Cell Industry Report on Market Metrics, Dynamics, and Trends @ http://www.reportsnreports.com/reports/206575-complete-2012-13-induced-pluripotent-stem-cell-industry-report.html.

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Induced Pluripotent Stem Cell Industry (iPSC Market) Report Updated for 2013 Now Available at ReportsnReports.com

IntelliCell BioSciences Receives US Patent for its Stem Cell Extraction Technology

NEW YORK, June 13, 2013 /PRNewswire/ --IntelliCell BioSciences, Inc. ("Company") (SVFC) announces that it has been notified by the US Patent office that its patent for stem cell extraction technology has been published. IntelliCell's proprietary patented method for deriving blood vessel originated vascular cells from adipose (fat) tissue by use of ultrasonic cavitation has been made official. This technology involves an innovative mechanical method for the separation of stromal vascular fraction cells from adipose (fat) tissue, without the use of enzymes. Vascular cells derived by IntelliCell's proprietary method are potentially useful in bringing the promise of regenerative medicine to many therapeutic and aesthetic procedures. Investors can access the published patent at the US Patent website by entering the patent # 8,440,440. Link to patent website: http://patft.uspto.gov/netahtml/PTO/srchnum.htm

IntelliCell's Chairman and CEO, Dr.Steven Victor, stated "Our Company is very pleased to announce today that with the publishing of our patent, our technology is now protected and we expect our international patent publication in a short time."

About IntelliCell BioSciences, Inc.

IntelliCellBioSciencesis a Regenerative Medicine company developing novel technologies that address the regenerative, curative and preventative conditions of disease states with high unmet clinical needs. The Company has several patent-pending applications including the patent that was recently published, an industry unique method of obtainingautologousstromalvascular fraction cells (SVF) cells from the vasculature surrounding adipose tissue containing adult stem cells and a robust population of regenerative healing cells. The Company is also pioneering the development ofautologousandallogeneiccells from living and non-living tissue donors for research purposes.IntelliCellis planning a series of in-human clinical studies with top tier universities for the treatment of osteoarthritis, multiple sclerosis, lower limb ischemic wounds, and gum regeneration in the oral cavity as well as medical aesthetics. The Company has developed a first in classcGTPcellular processing facility inNew York City, purpose built and designed to be fully integrated into an ambulatory surgery center.

Forward-Looking Statements

Certain statements set forth in this press release constitute "forward-looking statements." Forward-looking statements include, without limitation, any statement that may predict, forecast, indicate, or imply future results, performance or achievements, and may contain the words "estimate," "project," "intend," "forecast," "anticipate," "plan," "planning," "expect," "believe," "will likely," "will reach," "will change," "will soon," "should," "could," "would," "may," "can" or words or expressions of similar meaning. Such statements are not guarantees of future performance and are subject to risks and uncertainties that could cause the company's actual results and financial position to differ materially from those included within the forward-looking statements. Forward-looking statements involve risks and uncertainties, including those relating to the Company's ability to grow its business. Actual results may differ materially from the results predicted and reported results should not be considered as an indication of future performance. The potential risks and uncertainties include, among others, the Company's limited operating history, the limited financial resources, domestic or global economic conditions, activities of competitors and the presence of new or additional competition, and changes in Federal or State laws. More information about the potential factors that could affect the Company's business and financial results is included in the Company's filings, available via the United States Securities and Exchange Commission.

Contacts: Anna Rhodes, IntelliCell BioSciences, Inc. Phone: (646) 576-8710 Email: arhodes@intellicellbiosciences.com

Melissa Diaz, South Street Media, Inc. Phone: (917) 937-8968 Email: info@southstreetmedia.com

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IntelliCell BioSciences Receives US Patent for its Stem Cell Extraction Technology

Global Expert in Lung Disease Joins Cedars-Sinai to Lead New Stem Cell Research Program

Newswise LOS ANGELES (June 11, 2013) Barry R. Stripp, PhD, a recognized expert in lung disease and stem cell research, has been named director of the new Lung Stem Cell Research Program that spans the Womens Guild Lung Institute and the Regenerative Medicine Institute at Cedars-Sinai.

Stripp comes to Cedars-Sinai from Duke University Medical Center in Durham, N.C., where he has been professor in both the Department of Medicine and in Cell Biology since 2006. At Duke University Medical Center, Stripp was a member of the Division of Pulmonary, Allergy and Critical Care Medicine, led by Paul W. Noble, MD, who is now chair of the Department of Medicine at Cedars-Sinai. The recruitment of Stripp and Noble to Cedars-Sinai bring two leaders in lung disease research whose highly interactive programs have potential to develop new treatments for patients.

In May 2013, Stripp received a $5 million Research Leadership Award from the California Institute for Regenerative Medicine (CIRM) for his innovative strategies in stem cell technology and regenerative medicine. This award was granted to six world-class scientists and was created to help California universities and research institutions recruit the best stem cell scientists in the world.

The recruitment of Stripp to Cedars-Sinai and his recent CIRM grant are a reflection of his superb credentials and recognized contributions to the field of lung disease, regenerative medicine and stem cell technology, said Noble. We are pleased to welcome an outstanding scientist and educator of his stature to Cedars-Sinai and trust his contributions will result in improved treatments for patients locally and globally.

Stripps expertise will play a pivotal role in the new Cedars-Sinai stem cell research program, which launched in late 2012 and is a part of the Regenerative Medicine Institute. Focused on lung disease, including pulmonary disease, the division will bring together researchers and clinicians to discuss stem cell therapies in lung disease, provide core services that generate clinically relevant stem cell populations and use disease-specific stem cells to explore mechanisms of cell death in human lung disorders.

With funding from the CIRM grant and support from the leadership staff at Cedars-Sinai, I look forward to enhancing both the translational research component and clinical management of lung disease, said Stripp. These collaborative efforts will provide new therapeutic and surgical interventions for patients suffering from debilitating lung diseases that currently lack effective treatment options.

Stripps research interests focus on understanding cellular and molecular mechanisms of lung injury and repair. Defects in the maintenance and differentiation of epithelia lining small airways are commonly observed in chronic lung disease and represent a therapeutic target for interventions aimed at restoring lung function. His work has defined microenvironments within airways that maintain a population of adult tissue stem cells.

Through the work of Dr. Stripp and the new Lung Stem Cell Research Program, we will be able to determine how lung disease is caused, said Zab Mosenifar, MD, co-medical director of the Cedars-Sinai Womens Guild Lung Institute. This understanding will lead to new therapies that may prevent the initiation or the progression of lung disease, which is the third most likely cause of death in the United States.

Since opening in 2010, under the direction of Clive Svendsen, PhD, the Cedars-Sinai Regenerative Medicine Institute has received more than $30 million of grant support from the state stem cell agency. These grants have provided research funds for diseases of the central nervous system and skeleton, along with funding for novel development of stem cell technology.

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Global Expert in Lung Disease Joins Cedars-Sinai to Lead New Stem Cell Research Program

Mayo Clinic First in US to Test Stem Cells in Pediatric Congenital Heart Disease Patients

Released: 6/11/2013 2:00 PM EDT Source Newsroom: Mayo Clinic

June 11, 2013

MULTIMEDIA ALERT: Animation of the surgical procedure as well as audio and video of Drs. Nelson and Burkhart are available for download from the Mayo Clinic News Network.

http://www.mayoclinic.org/news2013-rst/7521.html

Newswise ROCHESTER, Minn. -- Mayo Clinic has announced the first U.S. stem cell clinical trial for pediatric congenital heart disease. The trial aims to determine how stem cells from autologous umbilical cord blood can help children with hypoplastic left heart syndrome (HLHS), a rare defect in which the left side of the heart is critically underdeveloped.

The trial will test the safety and feasibility of delivering a personalized cell-based therapy into the heart of 10 infants affected by HLHS. Today, treatment for babies born with HLHS involves three heart surgeries to redirect blood flow through the heart, or transplantation. The surgeries -- designed to provide adequate blood flow in and out of the heart, allowing the body to receive the oxygen-rich blood it needs -- are typically performed over the first few years of life. For this study, stem cells from newborns with HLHS will be collected from the umbilical cord following birth. The cord blood will be sent to a Mayo Clinic lab for processing, where the stem cells will be separated from the other cells in the blood. The stem cells will then be frozen for preservation. During the babys second surgery for HLHS -- typically performed at 4 to 6 months of age -- the stem cells will be injected into the heart muscle.

We want to see if these stem cells will increase the volume and strength of the heart muscle to give it greater durability and power to pump blood throughout the body, says Harold Burkhart, M.D., a pediatric cardiovascular surgeon with the Mayo Clinic Childrens Center.

About 960 babies are born with hypoplastic left heart syndrome each year in the U.S., the Centers for Disease Control and Prevention estimates. In this syndrome, the left side of the heart cant properly supply blood to the body because the lower left chamber (left ventricle) is too small or, in some cases, may not exist, Dr. Burkhart says. In addition, the valves on the left side of the heart (aortic valve and mitral valve) dont work properly, and the main artery leaving the heart (aorta) is smaller than normal, he says.

The care of these children with HLHS has been continuously improving since the first surgical procedure became available three decades ago, yet cardiac transplantation continues to be the limiting factor for far too many individuals, says Timothy Nelson, M.D., Ph.D., director of the Todd and Karen Wanek Family Program for HLHS in Mayo Clinics Center for Regenerative Medicine. Applying stem cell-based regeneration may offer a viable solution to help these children develop new tissues and grow stronger hearts.

# # # About Mayo Clinic Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.com and http://www.mayoclinic.org/news.

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Mayo Clinic First in US to Test Stem Cells in Pediatric Congenital Heart Disease Patients

Dr. Joseph Purita Celebrates New Study on Stem Cell Cartilage Formation

BOCA RATON, FL--(Marketwired - Jun 11, 2013) - At Stem Cell Orthopedics, Medical Director Dr. Joseph Purita and his staff, are focused on utilizing the latest practices in regenerative medicine to offer innovative procedures to patients suffering from a wide range of injuries and degenerative conditions. Specifically, Dr. Purita and the other board-certified orthopedic surgeons at Stem Cell Orthopedics concentrate on the progressive use of platelet rich plasma (PRP) injection and stem cell therapies. Although Purita has already gained increasing recognition for his revolutionary use of regenerative medicine, he is encouraged by the continuing progress found within the medical community.

As such, Dr. Joseph Purita highlights a recent study emerging from scientific researchers at the University of Pennsylvania focused in a new report from Science Daily. The article explains, "Bioengineers are interested in finding innovative ways to grow new cartilage from a patient's own stem cells, and, thanks to a new study from the University of Pennsylvania, such a treatment is a step closer to reality." Directed under the guidance of associated professor Jason Burdick, the research took a closer examination of how stem cells may improve and resolve the natural deterioration of cartilage experienced through aging, or sports injuries.

In the article, Burdick explains, "The broad picture is trying to develop new therapies to replace cartilage tissue, starting with focal defects -- things like sports injuries -- and then hopefully moving toward surface replacement for cartilage degradation that comes with aging. Here, we're trying to figure out the right environment for adult stem cells to produce the best cartilage."

Dr. Joseph Purita responds to the study, "Having successfully treated notable athletes with regenerative medicine procedures -- such as PRP therapy -- I am confident that stem cells will continue to offer more comprehensive benefits over traditional resolutions. While the research continues to develop, it is encouraging that in the near future patients will no longer have to opt for expensive invasive surgery options to repair damaged cartilage, joints, tissue, blood vessels and bone."

While Dr. Joseph Purita is excited by the scientific developments offered by the University of Pennsylvania research, he explains that there are many other benefits that may come with further studies. "While the scientific understanding of stem cells is critical to applying the resource in regenerative medicine, it is important to note that continued research will help ease the public's perception of regenerative medicine. As patients come to understand that the solution can be found in our own bodies, I believe the public will prove more open to these types of innovative therapies," Dr. Joseph Purita concludes.

ABOUT:

Dr. Joseph Purita is the Medical Director Stem Cell Orthopedics, a medical facility based in Boca Raton, Florida that specializes in regenerative medicine treatments. The facility serves a wide range of patients who are experiencing chronic pain as the result of a degenerative disorder or physical injury. This center is equipped with experienced board-certified orthopedic surgeons who understand how to target and treat specific conditions ranging from rheumatoid arthritis to tears in muscle tissue. While founded on a conventional knowledge of traditional orthopedics, this facility is regarded for its progressive use of emerging methodologies, including platelet rich plasma (PRP) injection, stem cell and cytokine therapies.

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Dr. Joseph Purita Celebrates New Study on Stem Cell Cartilage Formation

SanBio Announces FDA Clearance for the Initiation of a Phase I/2a Clinical Trial Testing Their Cell Therapy Product …

MOUNTAIN VIEW, Calif., June 10, 2013 /PRNewswire/ -- SanBio Inc., a California-based regenerative medicine company, announced today that the U.S. Food and Drug Administration has approved their Investigational New Drug application (IND) for the use of SB623, a novel allogeneic stem cell therapy product, in patients suffering from traumatic brain injuries (TBI's). This approval allows the company to proceed with a Phase 1/2a clinical trial testing the safety and feasibility of the therapy. The clinical trial is expected to be carried out at several major hospitals in the United States.

"This is the second clinical program for SanBio," said Keita Mori, SanBio's Chief Executive Officer, "we see this as a clear validation of our development program and a significant broadening of the therapeutic application of our lead product SB623 for the treatment of unaddressed chronic neurological deficits."

"We measure the responses of TBI patients to physical therapy every day. Progress is often painfully slow and incremental," said Dr. Daniel Lu, Principal Investigator, Neuroplasticity and Repair Laboratory and Director, Neuromotor Recovery Research Center, University of California, Los Angeles, "If this new cell therapy approach improves outcomes it could have a dramatic positive effect on many lives."

About Traumatic Brain Injury: According to the Center for Disease Control and Prevention, more the 1.7 million people in the United States sustain a traumatic brain injury each year, resulting in approximately 50,000 deaths and 275,000 hospitalizations. Many of these more severely injured patients suffer permanent disabilities, including loss of motor function and cognitive impairment. Other than physical rehabilitation there is no effective therapy. Direct medical costs and indirect costs such as lost productivity of TBI totaled an estimated $76.5 billion in the United States in 2000.

About SB623: SB623 is a proprietary cell therapy product consisting of cells derived from genetically modified bone marrow stromal cells obtained from healthy adult donors. SB623 is administered adjacent to the damaged area of the brain. SB623 functions by producing factors that aid the regenerative process.

About SanBio: SanBio is a privately held San Francisco Bay Area biotechnology company focused on the discovery and development of new regenerative cell therapy products.

For more information: http://www.san-bio.com

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SanBio Announces FDA Clearance for the Initiation of a Phase I/2a Clinical Trial Testing Their Cell Therapy Product ...

The Sentinel commented Staffordshire cancer sufferer undergoes revolutionary treatment

CANCER sufferer Kate Blackhurst is recovering at home after undergoing a revolutionary stem cell transplant to try to beat the disease.

The 20-year-old, picturedright, was offered the treatment on the NHS after being struck down with cancer twice in three years.

The latest treatment saw some of Kate's healthy stem cells frozen by experts at The Queen Elizabeth Hospital, in Birmingham.

She then received chemotherapy five times more powerful than a normal dose to try to kill the cancerous cells as the frozen stem cells were put back in her body during almost four weeks of treatment last month.

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The Sentinel commented Staffordshire cancer sufferer undergoes revolutionary treatment