Kris Aquino wants son Josh to undergo stem-cell therapy

Nais ni Kris Aquino na ipagamot ang panganay na anak na si Josh.

Ito ang isa sa mga dahilan na ibinahagi ng TV host-actress sa entertainment editor ng Balita na si Dindo Balares.

Ayon sa kolumn na Prangkahan na lumabas noong Biyernes, April 19, sinabi ni Kris, Ipapagamot ko kasi through stem-cell therapy sa Singapore this June si Josh.

Kuwento ni Kris, nahikayat siyang ipagamot ang kanyang 16-year-old na anak dahil sa positibong resulta sa pagpapagamot ng anak ng kanyang isang kaibigan.

Tulad ni Josh, may Attention Deficit Hyperactivity Disorder (AD-HD) din ang anak ng kaibigan ni Kris.

Lahad ni Kris, Hindi nakakapagsalita ang anak ng friend ko.

In fact, wala rin kahit eye contact.

Pero after ng treatment, ang laki-laki ng improvement, at nakakabuo na ng full sentence.

Dagdag pa niya, Gusto kong i-try. Kasi, ayokong maisip pagdating ng araw na may means naman ako to avail the treatment pero hindi ko ginawa.

Kung sakaling matuloy, kakailanganin daw ng buong atensyon ni Kris habang nagpapagamot si Josh.

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Kris Aquino wants son Josh to undergo stem-cell therapy

Stem cell transplant restores memory, learning in mice

Apr. 21, 2013 For the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember.

A study at the University of Wisconsin-Madison is the first to show that human stem cells can successfully implant themselves in the brain and then heal neurological deficits, says senior author Su-Chun Zhang, a professor of neuroscience and neurology.

Once inside the mouse brain, the implanted stem cells formed two common, vital types of neurons, which communicate with the chemicals GABA or acetylcholine. "These two neuron types are involved in many kinds of human behavior, emotions, learning, memory, addiction and many other psychiatric issues," says Zhang.

The human embryonic stem cells were cultured in the lab, using chemicals that are known to promote development into nerve cells -- a field that Zhang has helped pioneer for 15 years. The mice were a special strain that do not reject transplants from other species.

After the transplant, the mice scored significantly better on common tests of learning and memory in mice. For example, they were more adept in the water maze test, which challenged them to remember the location of a hidden platform in a pool.

The study began with deliberate damage to a part of the brain that is involved in learning and memory.

Three measures were critical to success, says Zhang: location, timing and purity. "Developing brain cells get their signals from the tissue that they reside in, and the location in the brain we chose directed these cells to form both GABA and cholinergic neurons."

The initial destruction was in an area called the medial septum, which connects to the hippocampus by GABA and cholinergic neurons. "This circuitry is fundamental to our ability to learn and remember," says Zhang.

The transplanted cells, however, were placed in the hippocampus -- a vital memory center -- at the other end of those memory circuits. After the transferred cells were implanted, in response to chemical directions from the brain, they started to specialize and connect to the appropriate cells in the hippocampus.

The process is akin to removing a section of telephone cable, Zhang says. If you can find the correct route, you could wire the replacement from either end.

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Stem cell transplant restores memory, learning in mice

TiGenix : positive Phase IIa study results in refractory rheumatoid arthritis with allogeneic stem cell product Cx611

Regulated information April 22, 2013

TiGenix reports positive Phase IIa study results in refractory rheumatoid arthritis with allogeneic stem cell product Cx611

Management will conduct a conference call to discuss the results today at 4pm CET, 10am EST Dial-in numbers are provided at the end of this press release

Leuven (BELGIUM) - April 22, 2013 - TiGenix (NYSE Euronext: TIG), the European leader in cell therapy, today announced positive 6-month safety data of its Phase IIa study of Cx611 in rheumatoid arthritis (RA), as well as a first indication of therapeutic activity on standard outcome measures and biologic markers of inflammation for at least three months after dosing.

The multicenter, randomized, double blind, placebo-controlled Phase IIa trial enrolled 53 patients with active refractory rheumatoid arthritis (mean time since diagnosis 15 years), who failed to respond to at least two biologics (mean previous treatment with 3 or more disease-modifying antirheumatic drugs and 3 or more biologics). The study design was based on a three-cohort dose-escalating protocol. For both the low and medium dose regimens 20 patients received active treatment versus 3 patients on placebo; for the high dose regimen 6 patients received active treatment versus 1 on placebo. Patients were dosed at day 1, 8, and 15 and were followed up monthly over a six-month period. Follow-up consisted of a detailed monthly workup of all patients measuring all pre-defined parameters. The aim was to evaluate the safety, tolerability and optimal dosing over the full 6 months of the trial, as well as exploring therapeutic activity.

Only one patient suffered serious adverse events that led to discontinuation of the treatment. All other side effects were mild and transient. Importantly, the first results show no signs of hematological side effects or thrombosis.

Measured clinical activity scores were ACR20(1), ACR50(1), ACR70(1), EULAR(2) response rates, and the disease activity score DAS28(3). To gain a first insight into the therapeutic activity, these parameters were evaluated every month for six months. The below tables reflect cumulated results in percentages of all three active treatment arms at months 1 (M1), 2 (M2), 3 (M3), and "final visit" (FV). A more detailed analysis is currently ongoing.

For all graphs, N=46 for Cx611 and N=7 for placebo.

Please click on the link at the bottom of the message to see the table ("Table1").

"This Phase IIa cell therapy trial is a landmark study that gives us a first indication of the potential of cell therapy in rheumatoid arthritis. The positive safety results combined with a new mechanism of action are promising, and warrant further clinical investigation," said Dr. Jos Mara lvaro-Gracia, MD, PhD, Head of the Biological Therapies Unit at the Hospital Universitario de La Princesa, Madrid, Spain, and Principal Investigator of the study.

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TiGenix : positive Phase IIa study results in refractory rheumatoid arthritis with allogeneic stem cell product Cx611

Fate Therapeutics Presents Preclinical Efficacy Data for WNT7A-Analog Program at Muscular Dystrophy Association 2013 …

SAN DIEGO, April 22, 2013 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc., a biopharmaceutical company engaged in the discovery and development of adult stem cell modulators, announced today the presentation of preclinical data from its WNT7a protein analog program for the treatment of muscular dystrophy at the Muscular Dystrophy Association (MDA) 2013 Scientific Conference, April 21-24, in Washington DC. The presentations describe the engineering of pharmaceutically optimized WNT7a protein analogs, as well as their mechanism of action and efficacy profile in preclinical pharmacology studies.

"The data presented today provide strong preclinical support for the therapeutic potential of WNT7a analogs in muscular dystrophy, a complex group of disorders with a large unmet need for novel, differentiated and potentially complementary treatment approaches," commented Christian Weyer, M.D., M.A.S., President and Chief Executive Officer of Fate Therapeutics. "We are working towards the nomination of an investigational new drug (IND) candidate later this year, and are excited about the potential to advance this new mechanism toward clinical studies."

In the MDX mouse model of muscular dystrophy, intramuscular injection of a novel WNT7a analog resulted in significant dose dependent muscle hypertrophy and several-fold expansion of the satellite stem cell population. Moreover, three weeks after a single intramuscular injection, functional assessment revealed a significant increase in strength of the targeted tibialis anterior muscle (+18%, p

The findings obtained with Fate's optimized WNT7a analogs expand upon those previously reported with non-modified WNT7a protein. In November 2012, muscle biology expert and Fate Therapeutics scientific founder Dr. Michael Rudnicki published data demonstrating the potential of WNT7a to ameliorate muscle degeneration in the MDX mouse model of muscular dystrophy (Von Maltzahn et. al., PNAS 2012). In previous studies, Dr. Rudnicki elucidated the unique biology of WNT7a and its dual mechanism of action of driving the expansion of the muscle satellite stem cell population and muscle hypertrophy.

About Muscular Dystrophy

Muscular dystrophies encompass a group of disorders with diverse pathophysiological manifestations resulting from genetic aberrations which include mutations or deletions to over 30 distinct genes. The most prevalent and well characterized is Duchenne muscular dystrophy (DMD), an X-linked form of muscular dystrophy which is seen in 1/3500 live male births. DMD typically manifests in early childhood and progresses to an advanced stage of severe muscular degeneration resulting in impairment of ambulation and premature mortality. A core pathophysiologic phenomenon seen in muscular dystrophy is a cycle of muscle degeneration leading to continuous compensatory satellite cell activation and differentiation to affect a regenerative response, but resulting in the eventual exhaustion of the regenerative capacity and significant loss of muscle function. Enhancing the underlying molecular and cellular mechanisms to restore the regenerative capacity of muscle satellite stem cells thus represents a promising and unique approach for therapeutically intervention in various forms of muscular dystrophy as well as other neuromuscular diseases.

About Fate Therapeutics, Inc.

Uniquely positioned at the intersection of stem cell science and orphan disease, Fate Therapeutics is pioneering the discovery and development of innovative adult stem cell modulator therapeutics with the potential to cure or transform the lives of patients with rare life-threatening disorders. The Company's lead program, ProHema, an innovative cord blood-derived cell therapy containing ex-vivo pharmacologically-modulated hematopoietic stem cells (HSCs), is currently in Phase 2 testing in patients with leukemia undergoing hematopoietic transplantation. The Company plans to pursue clinical evaluation of pharmacologically modulated HSCs in patients with rare genetic disorders, an area of tremendous unmet medical need in which the curative potential of cord blood transplantation is well recognized. In addition, Fate Therapeutics is developing proprietary WNT7a-based protein therapeutics that have shown efficacy in preclinical models of muscular dystrophy. To advance its discovery efforts, the Company applies its award-winning, proprietary, induced pluripotent stem cell (iPSC) technology to generate rare cell populations and model disease. Fate Therapeutics is headquartered in San Diego, CA, with a subsidiary in Ottawa, Canada. For more information, please visit http://www.fatetherapeutics.com.

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Fate Therapeutics Presents Preclinical Efficacy Data for WNT7A-Analog Program at Muscular Dystrophy Association 2013 ...

Voices Against Brain Cancer Comments on New Study Claiming Fat Tissue Stem Cells can Fight Brain Cancer

Medical Daily reports on a new study where stem cells from fat tissue were used to help track difficult regions in the brain prone to remission. Voices Against Brain Cancer releases a statement encouraging more stem cell research.

New York, NY (PRWEB) April 18, 2013

According to the Medical Daily article by Ansa Varughese, the study showed that stem cells from fat tissue can be used to track difficult regions in the brain prone to remission. Scientists cannot yet determine why or how these stem cells target the prone areas, but the cells seem naturally drawn to the damaged areas. Researchers are using the stem cells as transporters to help deliver drugs for treatment in the cancer spreading regions of the brain.

Alfredo Quinones-Hinojosa, the lead researcher and professor of neurosurgery, oncology, and neuroscience at Johns Hopkins, was quoted in the article as saying, The biggest challenge in brain cancer is the migration of cancer cells. Even when we remove the tumor, some of the cells have already slipped away and are causing damage somewhere else. Building off our findings, we may be able to find a way to arm a patient's own healthy cells with the treatment needed to chase down those cancer cells and destroy them. It's truly personalized medicine.

The Medical Daily article goes on to mention that harvesting the mesenchymal stem cells from the fat tissue is safer than getting the cells from bone marrow. While it will still take years before a clinical trial happens in the U.S., the new stem cell treatment could play a major part in battling brain cancer.

Michael Klipper, Chairman of VABC, offers his comments on the new study. This is a great step toward battling brain cancer. While its still a new study, it seems to be having positive results, and can hopefully become something used in brain cancer treatment in the future. Dealing with brain tumors and the treatment after can be a major, painful ordeal. Hopefully this new study will lead to a new way patients can be treated after theyve had a tumor removed.

VABC has a wide variety of initiatives in place for brain cancer research, awareness and support. The organizations research grants fund cutting-edge research programs that will have a monumental impact on the diagnosis and treatment of brain cancer. VABC currently funds research at several esteemed institutions such as Brookhaven National Laboratory, Cleveland Clinic, Columbia, Cornell, Duke, Harvard, John Hopkins, Memorial Sloan-Kettering and Yale, to name a few.

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Alicia McAllister 5W Public Relations 646-430-5155 Email Information

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Voices Against Brain Cancer Comments on New Study Claiming Fat Tissue Stem Cells can Fight Brain Cancer

Stem cell donor ditches Stanford University professor

MUMBAI: Healthy stem cells from a person of the same genetic make can mean life for Stanford University professor Nalini Ambady, or death if she doesn't find a donor in a month's time. A matching donor, recently found in Mumbai after an almost six-month-long search across India, backed out after initially consenting to stem-cell donation.

When her eight-year-old leukemia made a comeback last year, doctors in the US suggested she look for an Indian donor for a greater match probability, given ethnic similarities. After failing to find a match in the US' National Marrow Donor Program (NMDP) that boasts of a database of 10 million registered donors, Ambady's family finally directed their search towards India last November. Yet, two prominent stem cell donor registries in India with a combined pool of 50,000 donors could not find a match until recently.

Beating the odds of one in over 20,000, the unexpected happened last week when city-based Marrow Donor Registry of India (MDRI) found the Human Leukocyte Antigens (HLAs) match in a software engineer. HLA match refers to immunological compatibility, and doctors look for a match in at least 10 counts of crucial antigens to go ahead with a transplant. Coincidentally, not only did the donor hail from Ambady's hometown in Kerala, six out of 10 HLA parameters also matched. But Ambady's hopes crashed when after initially giving consent and registering as a donor, the engineer refused to go ahead with the donation citing health and later family problems.

Several rounds of counselling by members of MDRI, including founder head Sunil Parekh, did not cut much ice. Parekh said this was the sixth instance where the registry failed to convert a match into a transplant. Ambady's family and students have started a massive campaign across social media websites to hunt for a donor in time.

"Since we started the registry in 2010, there have been 55 requests for a match and we have managed to find six matches so far. But barring one instance, the donors backed out in all cases," he said, adding donor attrition has emerged as the biggest problem in the way of unrelated stem-cell transplants in the country.

While over 500 related stem cell transplants are carried out to cure leukemia, lymphoma and several other life-threatening cancers in the country annually, the numbers drop to almost one-tenth when it comes to transplants through unrelated donors. Also, in most of the unrelated stem cell transplants, the cells have to be imported from the US. "Just because the cells are imported, the cost of transplant could go up to around Rs 50 lakh and therefore remains out of bounds for the majority," said Dr Navin Khattry of Tata Memorial Hospital's Advanced Centre for Treatment, Research and Education in Cancer, which is the only one to carry out unrelated transplants in Mumbai. "The solution to this is obviously having a larger database of Indian donors," he said.

In global registries too, ethnic groups, particularly Asians, are not too well represented, which majorly reduces their chances of finding a match. According to Parekh, the problem of donor attrition only aggravates it and adds to the higher mortality rate. Donor attrition is usually due to apprehensions about the process and its long-term outcome. However, Parekh said stem cell donation, like blood donation, has no long-term effects on the donor and cells are replenished in six to eight weeks.

However, Raghu Rajagopal, the co-founder and CEO of Datri, which has the biggest database of 36,000 registered stem cell donors, said even global registries face an attrition of about 50%. "But in their case, if one donor backs out, there would be three more willing to come forward," he said.

Datri has also been holding camps for Ambady in Kochi. Ambady's family and friends, however, have appealed that only those who are serious about donating should come forward.

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Stem cell donor ditches Stanford University professor

Stem Cell Treatment in India for Diabetes : Testimonial – Video

Stem Cell Treatment in India for Diabetes : Testimonial
Stem cell treatment of diabetes is indicated at all stages of the disease. It is, however, the most effective in the cases of: New-onset insulin-dependent di...

By: StemRx BioScience

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Stem Cell Treatment in India for Diabetes : Testimonial - Video