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Long- and very long-chain ceramides are predictors of acute kidney … – Cardiovascular Diabetology

Marenzi G, Cosentino N, Bartorelli AL. Acute kidney injury in patients with acute coronary syndromes. Heart. 2015;101(22):177885.

Article CAS PubMed Google Scholar

Marenzi G, Cabiati A, Bertoli SV, Assanelli E, Marana I, De Metrio M, Rubino M, Moltrasio M, Grazi M, Campodonico J, et al. Incidence and relevance of acute kidney injury in patients hospitalized with acute coronary syndromes. Am J Cardiol. 2013;111(6):81622.

Article PubMed Google Scholar

Goldberg A, Hammerman H, Petcherski S, Zdorovyak A, Yalonetsky S, Kapeliovich M, Agmon Y, Markiewicz W, Aronson D. Inhospital and 1-year mortality of patients who develop worsening renal function following acute ST-elevation myocardial infarction. Am Heart J. 2005;150(2):3307.

Article PubMed Google Scholar

Kaltsas E, Chalikias G, Tziakas D. The incidence and the prognostic impact of acute kidney injury in acute myocardial infarction patients: current preventive strategies. Cardiovasc Drugs Ther. 2018;32(1):8198.

Article PubMed Google Scholar

Marenzi G, Assanelli E, Campodonico J, De Metrio M, Lauri G, Marana I, Moltrasio M, Rubino M, Veglia F, Montorsi P, et al. Acute kidney injury in ST-segment elevation acute myocardial infarction complicated by cardiogenic shock at admission. Crit Care Med. 2010;38(2):43844.

Article PubMed Google Scholar

Gault CR, Obeid LM, Hannun YA. An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol. 2010;688:123.

Article CAS PubMed PubMed Central Google Scholar

Anroedh S, Hilvo M, Akkerhuis KM, Kauhanen D, Koistinen K, Oemrawsingh R, Serruys P, van Geuns RJ, Boersma E, Laaksonen R, et al. Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients. J Lipid Res. 2018;59(9):172937.

Article CAS PubMed PubMed Central Google Scholar

Cheng JM, Suoniemi M, Kardys I, Vihervaara T, de Boer SP, Akkerhuis KM, Sysi-Aho M, Ekroos K, Garcia-Garcia HM, Oemrawsingh RM, et al. Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: results of the ATHEROREMO-IVUS study. Atherosclerosis. 2015;243(2):5606.

Article CAS PubMed Google Scholar

Laaksonen R, Ekroos K, Sysi-Aho M, Hilvo M, Vihervaara T, Kauhanen D, Suoniemi M, Hurme R, Mrz W, Scharnagl H, et al. Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol. Eur Heart J. 2016;37(25):196776.

Article CAS PubMed PubMed Central Google Scholar

Tu C, Xie L, Wang Z, Zhang L, Wu H, Ni W, Li C, Li L, Zeng Y. Association between ceramides and coronary artery stenosis in patients with coronary artery disease. Lipids Health Dis. 2020;19(1):151.

Article CAS PubMed PubMed Central Google Scholar

Peterson LR, Xanthakis V, Duncan MS, Gross S, Friedrich N, Volzke H, Felix SB, Jiang H, Sidhu R, Nauck M, et al. Ceramide remodeling and risk of cardiovascular events and mortality. J Am Heart Assoc. 2018. https://doi.org/10.1161/JAHA.117.007931.

Article PubMed PubMed Central Google Scholar

Tarasov K, Ekroos K, Suoniemi M, Kauhanen D, Sylvnne T, Hurme R, Gouni-Berthold I, Berthold HK, Kleber ME, Laaksonen R, et al. Molecular lipids identify cardiovascular risk and are efficiently lowered by simvastatin and PCSK9 deficiency. J Clin Endocrinol Metab. 2014;99(1):E45-52.

Article PubMed Google Scholar

Nwabuo CC, Duncan M, Xanthakis V, Peterson LR, Mitchell GF, McManus D, Cheng S, Vasan RS. Association of circulating ceramides with cardiac structure and function in the community: the framingham heart study. J Am Heart Assoc. 2019;8(19):e013050.

Article PubMed PubMed Central Google Scholar

Li PL, Zhang Y. Cross talk between ceramide and redox signaling: implications for endothelial dysfunction and renal disease. Handb Exp Pharmacol. 2013;216:17197.

Article CAS Google Scholar

Basnakian AG, Ueda N, Hong X, Galitovsky VE, Yin X, Shah SV. Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation. Am J Physiol Renal Physiol. 2005;288(2):F308-314.

Article CAS PubMed Google Scholar

Ueda N. Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate. Int J Mol Sci. 2015;16(3):5076124.

Article CAS PubMed PubMed Central Google Scholar

Ostermann M, Liu K. Pathophysiology of AKI. Best Pract Res Clin Anaesthesiol. 2017;31(3):30514.

Article PubMed Google Scholar

Raichur S, Brunner B, Bielohuby M, Hansen G, Pfenninger A, Wang B, Bruning JC, Larsen PJ, Tennagels N. The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach. Mol Metab. 2019;21:3650.

Article CAS PubMed PubMed Central Google Scholar

Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Bronneke HS, et al. Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. 2014;20(4):67886.

Article CAS PubMed Google Scholar

Fekry B, Jeffries KA, Esmaeilniakooshkghazi A, Ogretmen B, Krupenko SA, Krupenko NI. CerS6 is a novel transcriptional target of p53 protein activated by non-genotoxic stress. J Biol Chem. 2016;291(32):1658696.

Article CAS PubMed PubMed Central Google Scholar

Yacoub A, Hamed HA, Allegood J, Mitchell C, Spiegel S, Lesniak MS, Ogretmen B, Dash R, Sarkar D, Broaddus WC, et al. PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Cancer Res. 2010;70(3):11209.

Article CAS PubMed PubMed Central Google Scholar

Eberle M, Ebel P, Wegner MS, Mannich J, Tafferner N, Ferreiros N, Birod K, Schreiber Y, Krishnamoorthy G, Willecke K, et al. Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent. Biochem Pharmacol. 2014;92(2):32635.

Article CAS PubMed Google Scholar

Bai X, He T, Liu M, Li L, Chen J, Cao M, Liu Y, Yang C, Jia W, Tao K, et al. Integrative analysis of MicroRNAs and mRNAs in LPS-induced macrophage inflammation based on adipose tissue stem cell therapy. Inflammation. 2021;44(1):40720.

Article CAS PubMed Google Scholar

Hernandez-Corbacho MJ, Canals D, Adada MM, Liu M, Senkal CE, Yi JK, Mao C, Luberto C, Hannun YA, Obeid LM. Tumor Necrosis Factor-alpha (TNFalpha)-induced ceramide generation via ceramide synthases regulates loss of Focal Adhesion Kinase (FAK) and programmed cell death. J Biol Chem. 2015;290(42):2535673.

Article CAS PubMed PubMed Central Google Scholar

Kim YR, Lee EJ, Shin KO, Kim MH, Pewzner-Jung Y, Lee YM, Park JW, Futerman AH, Park WJ. Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases. Exp Mol Med. 2019;51(11):116.

PubMed PubMed Central Google Scholar

Stiban J, Perera M. Very long chain ceramides interfere with C16-ceramide-induced channel formation: a plausible mechanism for regulating the initiation of intrinsic apoptosis. Biochim Biophys Acta. 2015;1848(2):5617.

Article CAS PubMed Google Scholar

Nicholson RJ, Pezzolesi MG, Summers SA. Rotten to the cortex: ceramide-mediated lipotoxicity in diabetic kidney disease. Front Endocrinol (Lausanne). 2020;11:622692.

Article PubMed Google Scholar

Mantovani A, Lunardi G, Bonapace S, Dugo C, Altomari A, Molon G, Conti A, Bovo C, Laaksonen R, Byrne CD, et al. Association between increased plasma ceramides and chronic kidney disease in patients with and without ischemic heart disease. Diabetes Metab. 2021;47(1):101152.

Article CAS PubMed Google Scholar

Mitsnefes M, Scherer PE, Friedman LA, Gordillo R, Furth S, Warady BA. Ceramides and cardiac function in children with chronic kidney disease. Pediatric Nephrol (Berlin, Germany). 2014;29(3):41522.

Article Google Scholar

Ichi I, Kamikawa C, Nakagawa T, Kobayashi K, Kataoka R, Nagata E, Kitamura Y, Nakazaki C, Matsura T, Kojo S. Neutral sphingomyelinase-induced ceramide accumulation by oxidative stress during carbon tetrachloride intoxication. Toxicology. 2009;261(12):3340.

Article CAS PubMed Google Scholar

Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr, Ganiats TG, Holmes DR Jr, Jaffe AS, Jneid H, Kelly RF, Kontos MC, et al. 2014 AHA/ACC guideline for the management of patients with Non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2014;64(24):e139228.

Article PubMed Google Scholar

OGara PT, Kushner FG, Ascheim DD, Casey DE Jr, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;61(4):e78140.

Article PubMed Google Scholar

Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, Cannon CP, Van De Werf F, Avezum A, Goodman SG, Flather MD, et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163(19):234553.

Article PubMed Google Scholar

Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol. 1983;51(3):606.

Article CAS PubMed Google Scholar

Jia Y, Gao Y, Li D, Cao Y, Cheng Y, Li F, Xiao L, Jiang Y, Wan Z, Zeng Z, et al. Geriatric nutritional risk index score predicts clinical outcome in patients with acute ST-segment elevation myocardial infarction. J Cardiovasc Nurs. 2020;35(6):E44-e52.

Article PubMed Google Scholar

Jia Y, Li H, Li D, Li F, Li Q, Jiang Y, Gao Y, Wan Z, Cao Y, Zeng Z, et al. Prognostic value of Braden scale in patients with acute myocardial infarction: from the retrospective multicenter study for early evaluation of acute chest pain. J Cardiovasc Nurs. 2020;35(6):E53-e61.

Article PubMed Google Scholar

Mehran R, Aymong ED, Nikolsky E, Lasic Z, Iakovou I, Fahy M, Mintz GS, Lansky AJ, Moses JW, Stone GW, et al. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol. 2004;44(7):13939.

PubMed Google Scholar

Section 2: AKI Definition. Kidney international supplements 2012;2(1):1936. https://doi.org/10.1038/kisup.2011.32

Sarafian MH, Gaudin M, Lewis MR, Martin FP, Holmes E, Nicholson JK, Dumas ME. Objective set of criteria for optimization of sample preparation procedures for ultra-high throughput untargeted blood plasma lipid profiling by ultra performance liquid chromatography-mass spectrometry. Anal Chem. 2014;86(12):576674.

Article CAS PubMed Google Scholar

Huang Q, Hao S, Yao X, You J, Li X, Lai D, Han C, Schilling J, Hwa KY, Thyparambil S, et al. High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS: pregnancy baseline biomarkers and potential metabolic messengers. J Pharm Biomed Anal. 2021;192:113639.

Article CAS PubMed Google Scholar

Pickering JW, Blunt IRH, Than MP. Acute kidney injury and mortality prognosis in acute coronary syndrome patients: a meta-analysis. Nephrology (Carlton). 2018;23(3):23746.

Article PubMed Google Scholar

Yu J, Li D, Jia Y, Li F, Jiang Y, Zhang Q, Gao Y, Liao X, Zeng R, Wan Z. Nutritional risk screening 2002 was associated with acute kidney injury and mortality in patients with acute coronary syndrome: Insight from the REACP study. Nutr Metab Cardiovasc Dis. 2021;31(4):11218.

Article PubMed Google Scholar

Gencer B, Morrow DA, Braunwald E, Goodrich EL, Hilvo M, Kauhanen D, Sabatine MS, Laaksonen R, ODonoghue ML. Plasma ceramide and phospholipid-based risk score and the risk of cardiovascular death in patients after acute coronary syndrome. Eur J Prev Cardiol. 2020. https://doi.org/10.1093/eurjpc/zwaa143.

Article PubMed Google Scholar

Yao K, Wang Y, Xu D, Liu X, Shen C, Hu W, Wang Z, Wu R, Tang X, Sun A, et al. Effect of combined testing of ceramides with high-sensitive troponin T on the detection of acute coronary syndrome in patients with chest pain in China: a prospective observational study. BMJ Open. 2019;9(7):e028211.

Article PubMed PubMed Central Google Scholar

Abells-Sequeiros RA, Raposeiras-Roubn S, Abu-Assi E, Gonzlez-Salvado V, Iglesias-lvarez D, Redondo-Diguez A, Gonzlez-Ferreiro R, Ocaranza-Snchez R, Pea-Gil C, Garca-Acua JM, et al. Mehran contrast nephropathy risk score: Is it still useful 10 years later? J Cardiol. 2016;67(3):2627.

Article PubMed Google Scholar

Koowattanatianchai S, Chantadansuwan T, Kaladee A, Phinyo P, Patumanond J. Practical risk stratification score for prediction of contrast-induced nephropathy after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction. Cardiol Res. 2019;10(6):3507.

Article PubMed PubMed Central Google Scholar

Rodriguez F, Bonacasa B, Fenoy FJ, Salom MG. Reactive oxygen and nitrogen species in the renal ischemia/reperfusion injury. Curr Pharm Des. 2013;19(15):277694.

Article CAS PubMed Google Scholar

Ueda N, Camargo SMR, Hong X, Basnakian AG, Walker PD, Shah SV. Role of ceramide synthase in oxidant injury to renal tubular epithelial cells. J Am Soc Nephrol. 2001;12(11):238491.

Article CAS PubMed Google Scholar

Kalhorn T, Zager RA. Renal cortical ceramide patterns during ischemic and toxic injury: assessments by HPLC-mass spectrometry. Am J Physiol. 1999;277(5):F723-733.

CAS PubMed Google Scholar

Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Siddall P, Kuo MS, Perreault L. Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans. Am J Physiol Endocrinol Metab. 2015;309(4):E398-408.

Article CAS PubMed PubMed Central Google Scholar

Couto SMF, Machado DI, Conde C, Silva VC, Souza AA, Peres KB, Brandi BA, Vattimo MFF. Physical training is a potential modifier of risk for contrast-induced acute kidney injury in diabetes mellitus. Biomed Res Int. 2020;2020:1830934.

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Long- and very long-chain ceramides are predictors of acute kidney ... - Cardiovascular Diabetology

Novel chemokine related LncRNA signature correlates with the … – BMC Gastroenterology

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394424.

Article PubMed Google Scholar

Arnold M, Soerjomataram I, Ferlay J, Forman D. Global incidence of oesophageal cancer by histological subtype in 2012. Gut. 2015;64(3):3817.

Article PubMed Google Scholar

Hersznyi L, Tulassay Z. Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci. 2010;14(4):24958.

PubMed Google Scholar

Wang WL, Chang WL, Yang HB, Wang YC, Chang IW, Lee CT, Chang CY, Lin JT, Sheu BS. Low disabled-2 expression promotes tumor progression and determines poor survival and high recurrence of esophageal squamous cell carcinoma. Oncotarget. 2016;7(44):7116981.

Article PubMed PubMed Central Google Scholar

Aquino JL, Said MM, Pereira DA, Cecchino GN, Leandro-Merhi VA. Complications of the rescue esophagectomy in advanced esophageal cancer. Arq Bras Cir Dig. 2013;26(3):1738 ABCD = Brazilian archives of digestive surgery.

Article PubMed Google Scholar

Zhang J, Ling X, Fang C, Ma J. Identification and validation of an eight-lncRNA signature that predicts prognosis in patients with esophageal squamous cell carcinoma. Cell Mol Biol Lett. 2022;27(1):39.

Article CAS PubMed PubMed Central Google Scholar

Zheng ZJ, Li YS, Zhu JD, Zou HY, Fang WK, Cui YY, Xie JJ. Construction of the Six-lncRNA prognosis signature as a novel biomarker in esophageal squamous cell carcinoma. Front Genet. 2022;13: 839589.

Article CAS PubMed PubMed Central Google Scholar

Chi Y, Wang D, Wang J, Yu W, Yang J. Long Non-Coding RNA in the pathogenesis of cancers. Cells. 2019;8(9):1015.

Article CAS PubMed PubMed Central Google Scholar

Fang P, Chen H, Ma Z, Han C, Yin W, Wang S, Zhu H, Xia W, Wang J, Xu L, et al. lncRNA LINC00525 suppresses p21 expression via mRNA decay and triplex-mediated changes in chromatin structure in lung adenocarcinoma. Cancer Commun (London, England). 2021;41(7):596614.

Article Google Scholar

Sheykhhasan M, Ahmadyousefi Y, Seyedebrahimi R, Tanzadehpanah H, Manoochehri H, Dama P, Hosseini NF, Akbari M, Eslami Farsani M. DLX6-AS1: a putative lncRNA candidate in multiple human cancers. Expert Rev Mol Med. 2021;23: e17.

Article CAS PubMed Google Scholar

Bhan A, Soleimani M, Mandal SS. Long Noncoding RNA and Cancer: A New Paradigm. Can Res. 2017;77(15):396581.

Article CAS Google Scholar

Zhu J, Zhao Y, Wu G, Zhang X, Chen Q, Yang B, Guo X, Ji S, Gu K. Ferroptosis-related lncRNA signature correlates with the prognosis, tumor microenvironment, and therapeutic sensitivity of esophageal squamous cell carcinoma. Oxid Med Cell Longev. 2022;2022:7465880.

Article PubMed PubMed Central Google Scholar

Zhao F, Li Y, Dong Z, Zhang D, Guo P, Li Z, Li S. Identification of a risk signature based on lactic acid metabolism-related lncRNAs in patients with esophageal squamous cell carcinoma. Front Cell Dev Biol. 2022;10:845293.

Article PubMed PubMed Central Google Scholar

Zhao F, Dong Z, Li Y, Liu S, Guo P, Zhang D, Li S. Comprehensive analysis of molecular clusters and prognostic signature based on m7G-related lncRNAs in esophageal squamous cell carcinoma. Front Oncol. 2022;12: 893186.

Article PubMed PubMed Central Google Scholar

Shi X, Liu X, Pan S, Ke Y, Li Y, Guo W, Wang Y, Ruan Q, Zhang X, Ma H. A novel autophagy-related long non-coding RNA signature to predict prognosis and therapeutic response in esophageal squamous cell carcinoma. Int J Gen Med. 2021;14:832539.

Article CAS PubMed PubMed Central Google Scholar

Zhu T, Ma Z, Wang H, Wei D, Wang B, Zhang C, Fu L, Li Z, Yu G. Immune-related long non-coding RNA signature and clinical nomogram to evaluate survival of patients suffering esophageal squamous cell carcinoma. Front Cell Dev Biol. 2021;9:641960.

Article PubMed PubMed Central Google Scholar

Mantovani A, Savino B, Locati M, Zammataro L, Allavena P, Bonecchi R. The chemokine system in cancer biology and therapy. Cytokine Growth Factor Rev. 2010;21(1):2739.

Article CAS PubMed Google Scholar

Nagarsheth N, Wicha MS, Zou W. Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy. Nat Rev Immunol. 2017;17(9):55972.

Article CAS PubMed PubMed Central Google Scholar

Dangaj D, Bruand M, Grimm AJ, Ronet C, Barras D, Duttagupta PA, Lanitis E, Duraiswamy J, Tanyi JL, Benencia F, et al. Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors. Cancer Cell. 2019;35(6):885-900.e810.

Article CAS PubMed PubMed Central Google Scholar

Lim SJ. CCL24 signaling in the tumor microenvironment. Adv Exp Med Biol. 2021;1302:918.

Article PubMed Google Scholar

Harrow J, Frankish A, Gonzalez JM, Tapanari E, Diekhans M, Kokocinski F, Aken BL, Barrell D, Zadissa A, Searle S, et al. GENCODE: the reference human genome annotation for the ENCODE project. Genome Res. 2012;22(9):176074.

Article CAS PubMed PubMed Central Google Scholar

White NM, Cabanski CR, Silva-Fisher JM, Dang HX, Govindan R, Maher CA. Transcriptome sequencing reveals altered long intergenic non-coding RNAs in lung cancer. Genome Biol. 2014;15(8):429.

Article PubMed PubMed Central Google Scholar

Guo JC, Wu Y, Chen Y, Pan F, Wu ZY, Zhang JS, Wu JY, Xu XE, Zhao JM, Li EM, et al. Protein-coding genes combined with long noncoding RNA as a novel transcriptome molecular staging model to predict the survival of patients with esophageal squamous cell carcinoma. Cancer Commun (London, England). 2018;38(1):4.

Article Google Scholar

Zlotnik A, Yoshie O. The chemokine superfamily revisited. Immunity. 2012;36(5):70516.

Article CAS PubMed PubMed Central Google Scholar

Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol. 2014;32:659702.

Article CAS PubMed Google Scholar

Sokol CL, Luster AD. The chemokine system in innate immunity. Cold Spring Harb Perspect Biol. 2015;7(5):a016303.

Article PubMed PubMed Central Google Scholar

Tiberio L, Del Prete A, Schioppa T, Sozio F, Bosisio D, Sozzani S. Chemokine and chemotactic signals in dendritic cell migration. Cell Mol Immunol. 2018;15(4):34652.

Article CAS PubMed PubMed Central Google Scholar

Wang X, Zhao Y, Strohmer DF, Yang W, Xia Z, Yu C. The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma. Front Genet. 2022;13: 983672.

Article CAS PubMed PubMed Central Google Scholar

Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):2730.

Article CAS PubMed PubMed Central Google Scholar

Kanehisa M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 2019;28(11):194751.

Article CAS PubMed PubMed Central Google Scholar

Kanehisa M, Furumichi M, Sato Y, Ishiguro-Watanabe M, Tanabe M. KEGG: integrating viruses and cellular organisms. Nucleic Acids Res. 2021;49(D1):D545-d551.

Article CAS PubMed Google Scholar

Chi H, Xie X, Yan Y, Peng G, Strohmer DF, Lai G, Zhao S, Xia Z, Tian G. Natural killer cell-related prognosis signature characterizes immune landscape and predicts prognosis of HNSCC. Front Immunol. 2022;13:1018685.

Article CAS PubMed PubMed Central Google Scholar

Chi H, Jiang P, Xu K, Zhao Y, Song B, Peng G, He B, Liu X, Xia Z, Tian G. A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration. Front Genet. 2022;13: 984273.

Article CAS PubMed PubMed Central Google Scholar

Korbecki J, Kupnicka P, Chlubek M, Gorcy J, Gutowska I, Baranowska-Bosiacka I. CXCR2 receptor: regulation of expression, signal transduction, and involvement in Cancer. Int J Mol Sci. 2022;23(4):2168.

Article CAS PubMed PubMed Central Google Scholar

Bill CA, Allen CM, Vines CM. C-C Chemokine receptor 7 in cancer. Cells. 2022;11(4):656.

Article CAS PubMed PubMed Central Google Scholar

Gong X, Chi H, Strohmer DF, Teichmann AT, Xia Z, Wang Q. Exosomes: a potential tool for immunotherapy of ovarian cancer. Front Immunol. 2023;13:1089410.

Article PubMed PubMed Central Google Scholar

Yura M, Fukuda K, Matsuda S, Irino T, Nakamura R, Kawakubo H, Takeuchi H, Kitagawa Y. Effects of let-7a microRNA and C-C chemokine receptor type 7 expression on cellular function and prognosis in esophageal squamous cell carcinoma. BMC Cancer. 2022;22(1):1064.

Article CAS PubMed PubMed Central Google Scholar

Guo J, Tong CY, Shi JG, Li XJ. C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 7(CXCR7) regulates epithelial-mesenchymal transition process and promotes the metastasis of esophageal cancer by activating signal transducer and activator of transcription 3 (STAT3) pathway. Bioengineered. 2022;13(3):742538.

Article CAS PubMed PubMed Central Google Scholar

Zhong YB, Shan AJ, Lv W, Wang J, Xu JZ. Long non-coding RNA LINC00675 inhibits tumorigenesis and EMT via repressing Wnt/-catenin signaling in esophageal squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 2018;22(23):828897.

PubMed Google Scholar

Zhu Z, Wang H, Pang Y, Hu H, Zhang H, Wang W. Exosomal long non-coding RNA UCA1 functions as growth inhibitor in esophageal cancer. Aging. 2020;12(20):8581.

Article Google Scholar

Wang X, Gao Z, Liao J, Shang M, Li X, Yin L, Pu Y, Liu R. lncRNA UCA1 inhibits esophageal squamous-cell carcinoma growth by regulating the Wnt signaling pathway. J Toxicol Environ Health Part A. 2016;79(910):40718.

Article CAS Google Scholar

Wang X, Sun M, Gao Z, Yin L, Pu Y, Zhu Y, Wang X, Liu R. N-nitrosamines-mediated downregulation of lncRNA-UCA1 induces carcinogenesis of esophageal squamous by regulating the alternative splicing of FGFR2. Sci Total Environ. 2023;855: 158918.

Article CAS PubMed Google Scholar

Gautam SK, Basu S, Aithal A, Dwivedi NV, Gulati M, Jain M. Regulation of pancreatic cancer therapy resistance by chemokines. Semin Cancer Biol. 2022;86(Pt 2):6980.

Article CAS PubMed Google Scholar

Bhat AA, Nisar S, Maacha S, Carneiro-Lobo TC, Akhtar S, Siveen KS, Wani NA, Rizwan A, Bagga P, Singh M, et al. Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy. Mol Cancer. 2021;20(1):2.

Article PubMed PubMed Central Google Scholar

Fujikawa M, Koma YI, Hosono M, Urakawa N, Tanigawa K, Shimizu M, Kodama T, Sakamoto H, Nishio M, Shigeoka M, et al. Chemokine (C-C Motif) Ligand 1 derived from tumor-associated macrophages contributes to esophageal squamous cell carcinoma progression via CCR8-mediated Akt/Proline-rich Akt substrate of 40 kDa/Mammalian target of rapamycin pathway. Am J Pathol. 2021;191(4):686703.

Article CAS PubMed Google Scholar

Zhao Y, Wei K, Chi H, Xia Z, Li X. IL-7: a promising adjuvant ensuring effective T cell responses and memory in combination with cancer vaccines? Front Immunol. 2022;13:1022808.

Article CAS PubMed PubMed Central Google Scholar

Ugel S, Can S, De Sanctis F, Bronte V. Monocytes in the tumor microenvironment. Annu Rev Pathol. 2021;16:93122.

Article CAS PubMed Google Scholar

Cassetta L, Pollard JW. Targeting macrophages: therapeutic approaches in cancer. Nat Rev Drug Discovery. 2018;17(12):887904.

Article CAS PubMed Google Scholar

Wu Z, Zhang X, Chen D, Li Z, Wu X, Wang J, Deng Y. N6-Methyladenosine-related lncRNAs are potential remodeling indicators in the tumor microenvironment and prognostic markers in osteosarcoma. Front Immunol. 2021;12: 806189.

Article CAS PubMed Google Scholar

Zhou R, Liang J, Tian H, Chen Q, Yang C, Liu C. Development of a Ferroptosis-related lncRNA signature to predict the prognosis and immune landscape of bladder cancer. Dis Markers. 2021;2021:1031906.

Article PubMed PubMed Central Google Scholar

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New strategy positions B.C. as a global hub for life sciences | BC … – BC Gov News

Selina Robinson, Minister of Post-Secondary Education and Future Skills

Our life sciences sector is vital to creating a future of prosperity and innovation. Our Province is focused on preparing people for the jobs of tomorrow through our Future Ready plan, which will make education more accessible, affordable and relevant so we can build a stronger B.C. together.

Wendy Hurlburt, president and chief executive officer, Life Sciences BC

Building on the momentum of our life sciences thriving sector, this first-ever provincial life sciences strategy sets B.C. up to be a global leader in life sciences and will advance the health of British Columbians through the discovery and development of innovative products, solutions and services while diversifying and growing our economy by creating high-paying jobs.

Dr. Allen Eaves, president and chief executive officer, StemcellTechnologies

As Canadas largest biotechnology company, StemcellTechnologies is experiencing tremendous growth along with many other biotechs in B.C. All of us will require more homegrown research and biomanufacturing talent in the years ahead to remain internationally competitive.The B.C. governments Life Sciences and Biomanufacturing Strategy takes a thoughtful approach to strengthening the province from the perspective of both economic growth and health preparedness.

Bev Holmes, president and chief executive officer, Michael Smith Health Research BC

The new Life Sciences and Biomanufacturing Strategy further positions British Columbia as a leader in an area that is critical to peoplehere and around the world. The plan aligns with our work to support academic research and maximize benefits of clinical trials, which will create positive impacts on our economy, jobsand health.

Jennifer Figner, interim vice-president, academic and research, British Columbia Institute of Technology (BCIT)

BCITs mandate is to support the workforce development of the province, and we will play a major role in the training needsto ensure the future success and growth of the life sciences sector.With our partner, the Canadian Alliance for Skills and Training in Life Sciences, we look forward to welcominglearners to the National Biomanufacturing Training Centre.

Murray McCutcheon, senior vice-president, partnering, AbCellera

We believe that investments in life sciences talent and infrastructure are critical to building British Columbias ability to translate early scientific innovation into economic growth that makes our communities stronger today and tomorrow.

Suzanne Gill, president and chief executive officer, Genome BC

This new Life Sciences and Biomanufacturing Strategy will supercharge our already world-class life sciences sector and position us as a global leader in research and innovation, delivering new technologies and treatments that benefit B.C., Canadaand the world. Genome BC is proud to support this strategy by championing research and innovation to drive the responsible uptake of genomic technologies.

Cheryl Maitland, interim chief executive officer, Business Council of British Columbia

With an increasing number of scaling companies, highly skilled talent and research advancements, B.C.'s life sciences and biomanufacturing sector is asignificant source of employment, fuelling the growth of clean-tech businesses and contributing to our economy. The newly launched strategypresents a road map to build on these strengths and establish B.C. as a thriving global hubthat positively contributes to British Columbians health and economic well-being.

Deborah Buszard, interim president, University of British Columbia (UBC)

As B.C.s largest health-research and innovation organization and the lead institution for Canadas Immuno-Engineering and Biomanufacturing Hub, UBC welcomes the launch of the B.C. Life Sciences and Biomanufacturing Strategy and looks forward to continued collaboration with partners across academia, health care, industry, non-profits and government.Working together toward the strategys vision, we can create new opportunities for British Columbians and save more lives sooner.

Dr. Penny Ballem,member of the Council of Expert Advisors to the Government of Canada on biomanufacturing and life sciences

The life sciences strategy is an unprecedented opportunity for the remarkable life sciences sector in the province, our academic institutions and the health sector to leverage the investments being made by the federal and provincial government, and work together to benefit the lives of British Columbians and others across the country and globally, and support the biodiversity of our province and the planet.

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New strategy positions B.C. as a global hub for life sciences | BC ... - BC Gov News

Stem cell therapy Market | Global Upcoming Trends, Growth Drivers, Opportunities and Challenges 2031 – EIN News

PORTLAND, OR, UNITED STATES, April 12, 2023 /EINPresswire.com/ -- The global stem cell therapy market was valued at $205.1 million in 2021, and is projected to reach $928.6 million by 2031, growing at a CAGR of 16.2% from 2022 to 2031.

Stem cell therapy is a form of regenerative medicine that involves the use of stem cells to repair or replace damaged tissues and organs. Stem cells have the unique ability to develop into many different types of cells in the body, which makes them a promising tool for treating a variety of diseases and conditions.

The stem cell therapy market has grown significantly in recent years, driven by a number of factors including an aging population, an increase in chronic diseases, and advancements in stem cell research and technology. The market includes a range of therapies that use stem cells, including hematopoietic stem cell transplantation (HSCT), mesenchymal stem cell therapy (MSCT), and neural stem cell therapy (NSCT), among others.

The market for stem cell therapy is expected to continue to grow in the coming years, with a number of new therapies currently in development and clinical trials. However, there are also a number of challenges and regulatory hurdles that must be overcome in order for stem cell therapy to become widely adopted and accepted as a standard of care.

The report offers an extensive analysis of changing market dynamics, top segments, value chain, competitive landscape, and the Covid-19 pandemic impact. This report provides detailed information for market players, stakeholders, investors, and startups to help them devise strategies for gaining competitive edge and sustainable growth.

: https://www.alliedmarketresearch.com/request-sample/11317

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The Covid-19 pandemic made a negative impact on the stem cell therapy market, owing to disruptions and complexities in supply chain, manufacturing, and logistics processes. The costs and reimbursements related to the stem cell therapy were surged during the pandemic, owing to the lockdown restrictions imposed during pandemic.

The research and development activities were affected during the pandemic due to lockdown restrictions and lack of new investments. Many investors froze the investments for the uncertain period of time to cope up with the economic uncertainties.

Many medical procedures involving stem cell therapy were postponed due to focus on treatment of the Covid-infected patients and shift in hospital resources to Covid wards.

( , , , ) @ https://www.alliedmarketresearch.com/checkout-final/662b31f16976fb52ced0bf81e6e655e7

Based on cell source, the adipose tissue-derived mesenchymal stem cells segment held the highest share in 2021, accounting for more than half of the total share, and is projected to continue its leadership status during the forecast period. However, the bone marrow-derived mesenchymal stem cells segment is expected to manifest the highest CAGR of 16.9% from 2022 to 2031.

Based on application, the cancer segment accounted for the highest share in 2021, contributing to nearly half of the global stem cell therapy market, and is projected to maintain its lead in terms of revenue during the forecast period. Moreover, this segment is expected to manifest the highest CAGR of 16.8% from 2022 to 2031. The report also analyzes the segments including musculoskeletal disorder, wounds and injuries, cardiovascular disease, and others.

Based on type, the autologous transplants segment contributed to the highest share in 2021, holding more than half of the market, and is expected to dominate in 2031. However, the allogeneic transplants segment is projected to grow at the highest CAGR of 16.4% during the forecast period.

Based on region, North America accounted for the highest share in 2021, holding more than half of the global market, and is expected to maintain its dominance by 2031. However, Asia-Pacific is estimated to grow at the fastest CAGR of 19.0% during the forecast period. The research also analyzes regions including Europe and LAMEA.

- https://www.alliedmarketresearch.com/purchase-enquiry/11317

Leading market players of the global steam cell therapy market analyzed in the research include Allele Biotechnology and Pharmaceuticals, Inc., Fujifilm Holding Corporation, Astellas Pharma Inc., Novadip Biosciences, Mesoblast Ltd., Orthofix Holdings, Inc., NuVasive, Inc., Takeda Pharmaceutical Company Ltd., Smith & Nephew plc, and U.S. Stem Cell, Inc.

Grazoprevir Market: https://www.alliedmarketresearch.com/grazoprevir-market-A12479

Medical Waste Management Market : https://www.alliedmarketresearch.com/medical-waste-management-market

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Stem cell therapy Market | Global Upcoming Trends, Growth Drivers, Opportunities and Challenges 2031 - EIN News

Discussing the Future Role of Stem Cell Transplant in Multiple … – Targeted Oncology

Surbhi Sidana, MD

Assistant Professor

Department of Medicine

Division of Blood and Marrow Transplantation & Cellular Therapy

Stanford University School of Medicine

Stanford, CA

DISCUSSION QUESTIONS

SURBHI SIDANA, MD: Im a transplanter, so of course Im biased. What do you think about ASCT based on the results of the DETERMINATION study? Progression-free survival [PFS] was better [but] we dont see an overall survival [OS] difference.1 Did that change how you practice? Do you think it favors doing ASCT early [or shows that since] theres no difference in OS, we should not do the transplant?

ASHKAN LASHKARI, MD: As we incorporate MRD [minimal residual disease] assessment or diagnostic evaluations into our management of our patients with multiple myeloma, we might have a better way of determining whether we need to [transplant] or not. Thats a question that may be answered with the incorporation of MRD, at least in more clinical trials.

SIDANA: You bring up a great point, which is if youre MRD negative after induction, do you need a transplant? I dont think any of these trials answer that question because they did not randomly assign patients who were MRD negative versus MRD positive to ASCT versus no ASCT. I think we need to do these trials in the future.

Some of these trials are starting to happen in small phase 2 trial format. Currently, at least in the IFM 2009 trial [NCT01191060], even if you were MRD negative post hocthey were never randomly assigned based on MRD negativitythe MRD negativity did appear to be somewhat deeper and more sustained with the transplant.2 Those patients had a slightly better PFS. Whether that will hold true for DETERMINATION remains to be seen. I think what the transplant did was make it more sustained, at least in the IFM 2009 trial with 1 year of lenalidomide maintenance, versus no [transplant].

ANDY JANG, MD: I think the DETERMINATION trial is probably dampening the enthusiasm for ASCT for a couple of reasons. If I have a brand-new patient today whom I put on quadruplet therapies, I probably can [avoid transplant] for at least 7 years. Then you have CAR [chimeric antigen receptor] T-cell therapy, which gives you a very high overall response rate [above] 90%.3 The complete response rate is very high. Then you have other targets that are coming and CELMoDS [cereblon E3 ligase modulators]. Based on what I see right now and how effective the quadruplet therapy is, the transplant is probably going to get less emphasized.

SIDANA: Some of our standard-risk patients can get to [7 years on first-line therapy], but a lot of our high-risk patients [will not]. Do you change your practice patterns based on whether they have standard risk versus high risk?

JANG: Yes, of course. Butyou buy them so much [time]. Five years from now, the standard of care for multiple myeloma is definitely going to change. There may be a whole slew of other therapies. Because frontline therapy nowadays is so effectiveIm looking at the transplant value in general and looking at whats coming and whats already here. The CAR T-cell therapy data and even the bispecific antibody data are excellent in triple- or even penta-refractory patients.

SIDANA: Even though I am a transplanter, I hope one day ASCT will go away because every few years you want newer therapies that are less toxic to take over for older therapies. I think of it with a standpoint [where] were still not curing anybody, so lets use all of our treatments, ASCT included. But I hope one day that there is a treatment that can give us similar PFS and hopefully its less toxic and ASCT does go away.

SAM YEH, MD: I like the ASCT arm [in DETERMINATION] because I feel like patients do much better on maintenance than going back on treatment. You get [almost] 20 months extra PFS on the transplant arm based on DETERMINATION.4 Those [nearly] 2 years can give patients a good quality of life versus [if] the disease comes back, and they have lytic bone fractures and quality-of-life issues. There is going to be more toxicity going back on triplets or quadruplets versus when they go on ASCT, then they have a longer PFS and their quality of life may be better.

JANG: If you look at CAR T-cell therapy, it is also one-and-done, the patient has fairly good quality of life, and youre not giving them melphalan. The question is, do you go CAR T-cell therapy or ASCT; they are both one-and-done therapies. But with the transplant, you have to put them on maintenance. So you can argue the other way, [that CAR T-cell therapy is] one-and-done and gives patients a good quality of life.

YEH: CAR T-cell therapy is not indicated in that setting. Its much later.

JANG: That is why I said there is going to be less emphasis on the transplant [in the future] because a CAR T-cell therapy is one-and-done and the patient doesnt have to be on lenalidomide, you dont have to be on dexamethasone, and thats a tremendous selling point for the patient.

SIDANA: Both of you have good points. CAR T-cell therapy is one-and-done, but the indications are completely different. Right now, its fifth line for CAR T-cell therapy, first or second line for ASCT.5

JANG: Thats [true in this] moment in time. We know its not going to [require] 4 lines of therapy [in the future]. Its just because the trial was done that way. When Im going to refer CAR T-cell therapy, Im not going to wait for fourth-line therapies. Im going to start referring them when they have triple or quadruple failures. But right now, I understand the label. Looking atthe future of myeloma therapies, its not going to [require] a fourth-line therapy [before] you refer to CAR T-cell therapy. Its going to change.

SIDANA: I hope its a one-and-done but in all the trials that were designed in early lines, were adding maintenance to the CAR T-cell therapy. Theres a trial coming comparing ASCT to CAR T-cell therapy [CARTITUDE-6; NCT05257083] and theres going to be [lenalidomide] maintenance in the CAR T-cell therapy arm. Im hoping with CAR T-cell therapy we can continue it because patients love the treatment-free interval. They tell me thats the best few months of their life, but because patients still relapse, we are [acting like] ASCT used to be, with no maintenance. But then we added maintenance.

I see whats coming down the pipeline and worry that were going to add maintenance to [CAR T-cell therapy], too, but perhaps not for everybody. We will find out in the future if we need to do that for everybody.

References:

1. Richardson PG, Jacobus SJ, Weller EA, et al. Triplet therapy, transplantation, and maintenance until progression in myeloma.N Engl J Med. 2022;387(2):132-147. doi:10.1056/NEJMoa2204925

2. Attal M, Lauwers-Cances V, Hulin C, et al. Lenalidomide, bortezomib, and dexamethasone with transplantation for myeloma.N Engl J Med. 2017;376(14):1311-1320. doi:10.1056/NEJMoa1611750

3. Berdeja JG, Madduri D, Usmani SZ, et al. Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study. Lancet. 2021;398(10297):314-324. doi:10.1016/S0140-6736(21)00933-8

4. Richardson PG, Jacobus SJ, Weller EA, et al. Triplet therapy, transplantation, and maintenance until progression in myeloma.N Engl J Med. 2022;387(2):132-147. doi:10.1056/NEJMoa2204925

5. NCCN. Clinical practice guidelines in oncology. Multiple myeloma, version 3.2023. Accessed March 30, 2023. https://bit.ly/2T0mDYS

Continued here:
Discussing the Future Role of Stem Cell Transplant in Multiple ... - Targeted Oncology

They Drew Out Fluid From My Spine: Rey Mysterio Details How an Aggressive Stem Cell Treatment Saved Him From Voluntary Retirement in 2014 -…

Rey Mysterio had a grand WrestleMania weekend last Saturday, defeating his son Dominik Mysterio after an intense physical bout. Just a day before that big victory, the senior Mysterio also headlined the WWE Hall of Fame 2023.

The 48 year couldnt be more satisfied experiencing two remarkable moments of his storied career back to back. But that moment wouldnt have come if he retired after his humiliating defeat against Samoa Joe at WrestleMania 35. The WWE Hall of Famer once made up his mind about retirement after that match.

However, fortunately, that didnt happen, for the legendary star. He decided to work on his physique which hindered his strength in facing the young stars on the roster. Keeping aside the temporary thought of quitting, the Hall of Famer chose to undergo stem cell treatment that later immensely benefited him in restoring fitness.

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A wrestlers injury proneness is no secret to fans. But sometimes the injuries are so gruesome that it becomes career-ending, even life-threatening to some extent. Rey Mysterio faced a similar situation back in 2014 when he found his body unfit for a highly physical sport like wrestling. But then it was a costly full-body stem cell treatment that came to his save.

Speaking on the IMPAULSIVE podcast, Mysterio recalled the life-saving therapy he underwent. Detailing the rigorous treatment process, he noted, Every day I ran into stem cells and ever since then you know thats been my final youth. The first couple of times that I did it was actually here and then I got connected to the place in Colombia and they shot me up like full body both knees ankles shoulders biceps. I have carpel tunnel so wrists, my spine, they drew out fluid from my spine.

Rey further reflected on how aggressive and painful this whole treatment process has been for him. It even caused numbness in the whole body for 24 hours after the therapy. But then his temporary discomfort brought him permanent peace and that is something Rey will always be grateful for. But how exactly did the famed wrestler become susceptible to severe injuries that limited his in-ring performances?

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Despite being a marquee talent Mysterio dealt with numerous injuries throughout his career. Since 2012, there are very few years that didnt bring any injury to him. Especially his knees were dangerously prone to injuries. After handling major knee injuries back in 1997 during his bout with Juventud Guerrera, another grueling one came with a gap of 8 years.

Then the third and the most threatening one came in the 2013 Royal Rumble when he felt like his in-ring stint was about to end. There were many other biceps, and wrist injuries as well, in between these years. The recent injury the master of 619 had to deal with was in 2022 when he suffered a leg injury following his Intercontinental championship match against Gunther.

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Watch the story: GSP Offered By WWE

However, It seems like the new WWE Hall of Famer is now completely fit and fine to perform at his level best in the squared circle for some more years. What do you make of Mysterios story? Let us know your thoughts in the comments section below.

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They Drew Out Fluid From My Spine: Rey Mysterio Details How an Aggressive Stem Cell Treatment Saved Him From Voluntary Retirement in 2014 -...

Novo’s latest deal targets cell therapy for diabetes, obesity – BioPharma Dive

Dive Brief:

Novo, while historically not big on buyouts, has turned to acquisitions over the past couple years to expand its slate of technologies and research programs. In late 2021, it agreed to spend north of $3 billion on Dicerna Pharmaceuticals, a company specialized in so-called RNA interference. And in 2022, it picked up Forma Therapeutics in a $1 billion deal that provided an experimental drug for sickle cell disease in late-stage clinical testing.

Yet, Novos core business still revolves around diabetes and, more recently, obesity. Aided by newer drugs like Rybelsus, Wegovy and, especially, Ozempic, the company last year recorded a 26% increase in net sales and a 34% increase in gross sales.

The new collaboration with Aspect indicates that Novo sees further room to grow in its core areas. Per deal terms, Aspect is eligible to receive as much as $650 million for each resulting product, provided it hits certain developmental, regulatory, commercial and sales goals. Additionally, the biotech would get tiered royalties on future sales of any products.

The deal also further entrenches Novo in the field of cellular medicine. The company established a California-based manufacturing site dedicated to stem cell therapies in 2018. And currently, its researching ways that cell therapies could be used to treat illnesses like Parkinsons disease, chronic heart failure and Type 1 diabetes.

Partnering with Aspect adds an important component to our strategy to develop comprehensive cell therapy products, Jacob Sten Petersen, Novos head of cell therapy research and development, said in a statement.

Novo isnt alone in its pursuits, however. Just last month, Vertex Pharmaceuticals announced that it would be licensing gene editing technology from CRISPR Therapeutics to develop therapies for Type 1 diabetes. The two companies had already been collaborating on a gene editing therapy for sickle cell and another blood disorder, and CRISPR had been working with the biotech Viacyte on its own Type 1 diabetes cell therapy program.

Vertex bought Viacyte last year for $320 million, hoping that the biotechs tools would help accelerate the development of VX-880, an experimental, stem-cell-derived therapy targeting Type 1 diabetes, which Vertex got through its $950 million acquisition of Semma Therapeutics in 2019.

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Novo's latest deal targets cell therapy for diabetes, obesity - BioPharma Dive

Stem Cell Junk Yards Reveal a New Clue About Aging – WIRED

Robert Signer sees himself as an auto mechanic for human cells. The professor of regenerative medicine at UC San Diego is intrigued by the elusive secrets of the stem cells in our blood. These are a class of rejuvenating entities that replenish supplies of red and white blood cells and platelets. Their job is to help keep our bodies healthy, but as we age their performance dips. When they fail, it can lead to blood cancers, anemia, clotting issues, and immune problems. Signers job is to understand why, and he thinks the answer has to do with how they handle their garbage.

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Our cells assemble around 20,000 specific proteins that allow us to do everything from digesting dairy to killing tumors. But the process isnt perfect. When cells mess up, they wind up with whats essentially junk: proteins with missing, extra, or incorrect amino acids in their chains. These can settle into unexpected shapes and malfunctionor worse. They start to stick together, and they form these aggregates, Signer says. Aggregates gum up the machine. Misfolded proteins can actually be toxic. (Researchers have linked Alzheimers disease to gummed-up clumps of protein.)

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Most mature blood and immune cells live fast and die hard. They thrive by churning out protein after protein, and mistakes are part of the deal. But life moves slowly for a stem cell. Even modest increases in protein production can be very catastrophic, says Signer. If they make a mistake, waste leads to worse performance, which leads to more waste. So stem cells trying to survive for the long haul must manage their waste like pros.

A healthy stem cell keeps tight control over proteins production and destruction, and this ability to maintain what researchers call protein homeostasis is what fades with age. We think that if we can jump in and prevent this from happening, or improve the ability of stem cells to maintain this protein homeostasis, then we might be able to prevent the decline in stem cell function and the diseases that are associated with those changes, says Signer.

Biologists have long known that stem cells run a tight ship, but not how. So writing in the journal Cell Stem Cell in March, Signers team reported an up-close look at what happens inside the stem cells of young and old mice. (You can't be a good mechanic if you've never looked under the hood, Signer says.)

What they learned was surprising. Biologists had previously assumed that stem cells stay tidy by breaking down waste as fast as it arises, reducing junk proteins into amino acid fodder they can reuse immediately. But Signers group found that blood's stem cells actually squirrel away their misfolded waste and only recycle it when they need it. Scientists had seen this behavior before, but they thought that cells did it in rare cases, when under extreme stress. Signer now believes that healthy stem cells do this as a baselineits a way of pacing themselves in order to maintain control. The mouse data showed that this sophisticated process breaks down with age.

This revelation offers insight into why we age and what critical cellular machinery we must keep running to combat age-related diseases, according to Maria Carolina Florian, a stem cell biologist at the Catalan Institution for Research and Advanced Studies who was not involved in the work. To Florian, it suggests the possibility of creating drugs that can maintain this control for stem cells. It looks particularly important, she says, because of this possibility to be targetedto be able to reverse aging.

Signers lab studied blood stem cells taken from mouse bone marrow. Doctoral researcher Bernadette Chua first extracted marrow from young mice (ages 6 to 12 weeks) and isolated several types of cellsstem cells as well as blood and immune cellsto observe them during an early stage of development. Then, using fluorescent molecules that stick to specific components of the cell, she snooped on each to see how it was managing its trash.

Cells use proteasomes, protein complexes containing enzymes that immediately chew up their misfolded proteins. But Signers lab had previously found that, like neural stem cells, blood stem cells in young mice dont rely on proteasomes very much. In this new experiment, Chua and Signer found that instead of breaking down misfolded proteins right away, stem cells swept them out of the way, collecting them into piles, like mini junk yards. Later, they disintegrated them with a different protein complex called an aggresome. We believe that by storing these misfolded proteins in one place, they're basically holding onto those resources for when they need them, Signer says. Collecting piles of waste may let cells control the pace of their recycling and, as a result, avoid living too fast or too slow.

Yet when Chua next examined marrow from 2-year-old mice, she found a shocking breakdown in this waste management system. Older mice lost their ability to form aggresomes almost entirely at least 70 percent of the stem cells in young mice do it, but only 5 percent in old mice. Instead, old mice swapped to using more proteasomes, a move Signer likens to slapping a spare tire onto an aging car. That was definitely a surprise, Signer says.

This change in waste control machinery is bad news for stem cells. Mice that were genetically engineered to not cache their trash had four times fewer surviving stem cells in their bone marrow in old age. It suggests that those cells are aging, and expiring, faster than they were before.

This distinction between enzymes, wonky as it sounds, could prove crucial for efforts to harness stem cells as anti-aging therapies because it runs counter to previous assumptions. Let's say that you want to engineer a stem cell for regenerative medicine, says Dan Jarosz, a systems biologist from Stanford University who was not involved in the work. Before reading this, I might have thought that a really good thing to do would be to amp up the proteasome activity.

The idea that young, healthy stem cells control the pace of their lives by collecting debris into a storage center, instead of consuming it immediately, is very cool, he continues. This suggests that we need a much more nuanced understanding of how protein quality control functions in aging.

Why older stem cells change their behavior remains an open question. Florian suspects it has something to do with how cells change shape as they age. A healthy cell is typically lopsided, as its contents are sectioned into distinct compartmentsthis asymmetric shape is referred to as being polarized. But stem cells lose their polarity with age, and this affects their ability to shuttle waste to their storage center.

Florians lab is developing drugs that maintain cell polarization. Last year, she reported rejuvenating mouse stem cells with a treatment that tamps down the activity of an overactive enzyme that messes with cell polarity. When transplanted into immunocompromised mice, the stem cell treatment extended their median lifespans by over 12 weeks, or 10 percent. It has a very profound effect on the blood, she says. Basically, you rejuvenate the blood of the mice, and they leave healthier and longer. (Florian serves on the advisory board for rejuvenation start-up Mogling Bio.)

For his part, Signer imagines a drug that maintains the equipment that stem cells use to compost malformed proteinshe doesnt yet know what that would be, but the new experiment gives researchers an idea of where to look. Figuring out that stem cells trash collection system falls apart as the cells age is important, he says, because pinpointing what goes wrong with age gives us an idea of how to target future fixes.

Signer and Florian admit that any drug meant to keep cells young and active carries some cancer risk. Older cells activate genes that prevent tumors and suppress stem cells. Its possible that helping stem cells survive in old age will help cancer cells do the same.

But I also think that there is an alternative possibility happening in parallel, Signer says. Maybe helping stem cells clear their trash slowly and steadily prevents the cascade of effects that lead to problems like cancer, he says: If we can prevent some of those changes, we might be able to prevent multiple types of age-related diseases.

Read more here:
Stem Cell Junk Yards Reveal a New Clue About Aging - WIRED

Regenerative Medicine Market Investments, Share and Revenue Analysis | Latest InsightAce Report – Yahoo Finance

InsightAce Analytic Pvt. LTd.

The global Regenerative Medicine market is estimated to reach over USD 183.08 billion by 2031, exhibiting a CAGR of 15.02% during the forecast period

Jersey City, NJ, April 12, 2023 (GLOBE NEWSWIRE) -- InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the "GlobalRegenerative Medicine Market Size, Share & Trends Analysis Report By Product (Therapeutics, Primary cell-based therapeutics, Stem Cell & Progenitor Cell-based therapeutics), By Therapeutic Category (Dermatology, Musculoskeletal, Immunology & Inflammation, and Oncology)- Market Outlook And Industry Analysis 2031"

The global Regenerative Medicine market is estimated to reach over USD 183.08 billion by 2031, exhibiting a CAGR of 15.02% during the forecast period.

In recent year, it has been determined that regenerative therapies can uniquely change the underlying pathological processes. Trial-stage regenerative medicines offer promising treatments for particular chronic diseases with unmet medical needs. Novartis announced the release of T-ChargeTM in December 2021, a next-generation CAR-T platform that would be used for cutting-edge investigational CAR-T cell treatments.

Free PDF Report Brochure @https://www.insightaceanalytic.com/request-sample/1687

The development of gene-based treatment, which uses targeted DNA delivery as a drug to combat numerous illnesses, results from significant effects in molecular therapeutics. With the restoration of gene function, gene therapy holds great promise for treating cancer and type 1 and type 2 diabetes. Gene-based medicines treat patients with conditions such as cancer, oncology, infectious diseases, cardiovascular disorders, monogenic diseases, genetic disorders, ophthalmological indications, and central nervous system illnesses. These elements have helped the market for regenerative medicine expand.

Recent Developments:

In April 2022, Obecabatagene autoleucel, a CD19-directed autologous chimeric antigen receptor T therapy being investigated in the ongoing FELIX Phase 2 study of leukaemia, has been given the Regenerative Medicine Advanced Therapy designation by the U.S. Food and Drug Administration (FDA). This was announced by Autolus Therapeutics plc.

Story continues

List of Prominent Players in the Regenerative Medicine Market:

AstraZeneca plc;

F. Hoffmann-La Roche Ltd.;

Integra Lifesciences Corp.;

Astellas Pharma, Inc.;

Cook Biotech, Inc.;

Bayer AG;

Pfizer, Inc.;

Merck KGaA;

Abbott;

Vericel Corp.;

Novartis AG;

GlaxoSmithKline (GSK);

Baxter International, Inc.;

Boehringer Ingelheim;

Amgen, Inc.;

Cesca Therapeutics, Inc.;

U.S. Stem Cell, Inc.;

Bristol-Myers Squibb;

Eli Lilly and Company;

NuVasive, Inc.;

Organogenesis, Inc.;

MiMedx Group, Inc.;

Takara Bio, Inc.;

Osiris Therapeutics, Inc.;

Corline Biomedical AB

Get Customized Report @https://www.insightaceanalytic.com/customisation/1687

Regenerative Medicine Market Report Scope:

Report Attribute

Specifications

Market size value in 2022

USD 52.66 Bn

Revenue forecast in 2031

USD 183.08 Bn

Growth rate CAGR

CAGR of 15.02 % from 2023 to 2031

Quantitative units

Representation of revenue in US$ Million, and CAGR from 2023 to 2031

Historic Year

2019 to 2022

Forecast Year

2023-2031

Report coverage

The forecast of revenue, the position of the company, the competitive market statistics, growth prospects, and trends

Segments covered

Product And Therapeutic Category

Regional scope

North America; Europe; Asia Pacific; Latin America; Middle East & Africa

Country scope

U.S.; Canada; U.K.; Germany; China; India; Japan; Brazil; Mexico; The UK; France; Italy; Spain; China; Japan; India; South Korea; Southeast Asia; South Korea; Southeast Asia

Market Dynamics:

Drivers- The ability of adult stem cells to proliferate or self-renew forever and to develop all the cell kinds of the organ from which they originate has propelled research into these cells, with the potential to regenerate the complete organ from a few cells. No embryo must be destroyed in order to produce adult stem cells. Furthermore, medical research on stem cells has been thoroughly examined and attracted much attention. ExCellThera Inc. and Ossium Health recently announced a partnership to explore and advance opportunities to use adult stem cells from deceased donors from Ossium Health's first-ever bone marrow bank in combination with ExCellThera's ECT-001 cell expansion and rejuvenation technology. This collaboration will take place in April 2021. These kinds of developments are anticipated to accelerate market expansion.

Challenges:The market for regenerative medicine is projected to be hampered by a lack of information and moral considerations surrounding the usage of embryonic stem cells for research and development. Since cell therapy is a crucial component of regenerative medicine, it has a significant impact on the market growth rate. One of the leading market inhibitors may be the high cost of investment, which might be followed by problems with assay sensitivity, robustness, and reproducibility; the challenge of culture/propagation; and finally, the challenge of handling.

Regional Trends:Due to the presence of big players, the rapid advancement of technology, significant investments in stem cell and oncology research, and the presence of major players, North America is predicted to have the largest revenue share. The largest market in North America is the United States. In the U.S., numerous stem cell therapies are increasingly being used to treat a growing number of ailments like cancer and diabetes. According to the Heart Disease & Stroke Statistics Fact Sheet 2020, congenital heart abnormalities are predicted to affect at least 40,000 infants annually in the United States.

Enquiry Before Buying @https://www.insightaceanalytic.com/enquiry-before-buying/1687

Segmentation of Regenerative Medicine Market-

By Product-

Therapeutics

Primary cell-based therapeutics

Dermatology

Musculoskeletal

Surgical

Dental

Others

Stem Cell & Progenitor Cell-based therapeutics

Autologous

Allogenic

Others

Cell-based Immunotherapies

Gene Therapies

Tools

Banks

Services

By Therapeutic Category-

By Region-

North America-

Europe-

Germany

The UK

France

Italy

Spain

Rest of Europe

Asia-Pacific-

China

Japan

India

South Korea

South East Asia

Rest of Asia Pacific

Read more:
Regenerative Medicine Market Investments, Share and Revenue Analysis | Latest InsightAce Report - Yahoo Finance

Modified stem cell therapy extends survival in infantile Batten… – Batten Disease News

A treatment using stem cells modified to produce PPT1 the missing enzyme in infantile Batten disease prevented symptoms from developing and substantially extended survival in a mouse model of the disease, a study reports.

It also prolonged survival and slowed disease progression when given to mice that had already developed symptoms, a remarkable result, the researchers wrote in An innovative hematopoietic stem cell gene therapy approach benefits CLN1 disease in the mouse model, which was published in EMBO Molecular Medicine.

The findings support further studies on this therapeutic strategy, they said.

Infantile Batten, also called CLN1 disease, is a severe type of Batten diseasecaused by mutations in the PPT1 gene,which provides instructions for making an enzyme that helps break down complex molecules in cells.

Without a working version of the PPT1 enzyme, molecules called lipofuscins build up to toxic levels and damage cells, especially those in the brain, promoting neuroinflammation.

Within the brain, immune cells called microglia are involved in neuroinflammation and in clearing molecular waste. They may therefore be invaluable targets for treating disorders like Batten disease that feature the toxic accumulation of molecular waste.

Hematopoietic stem and progenitor cells (HSPCs) are stem cells that normally live in the bone marrow and give rise to blood cells, including most immune cells. Under the right conditions, theyre able to grow into microglia-like cells, suggesting their transplantation could restore efficient waste clearance.

Scientists in the U.S. and Italy tested the effects of delivering HSPCs from healthy mice directly into the bloodstream of a mouse model of infantile Batten. Before treatment, the mice were given a myeloablative regime, consisting of chemotherapy to destroy their existing HSPCs.

Compared with untreated mice, those treated with healthy HSPCs showed markedly less severe disease, as measured with a new scale devised by the researchers, results showed. They also lived significantly longer relative to untreated animals (median, 248 vs. 228 days).

These data represent the first demonstration that [HSPC] transplantation could be beneficial in CLN1 disease, wrote the researchers, who then tested the effects of HSPCs they genetically modified to produce higher than normal levels of the PPT1 enzyme. The new treatment led to further improvements in survival and reductions in measures of disease severity.

By day 260 (about eight months), all the untreated mice had either died or reached conditions where it was considered inhumane to keep them alive. But 77% of mice treated with the modified HSPCs were still alive. Most of them (68%) were also still alive after a year.

Analyses of the treated animals that died suggested the cause of death was usually not related to Batten. Instead, most died due to complications associated with the myeloablative regime.

The team then showed that administering the modified stem cells directly into the brain had comparable effects to the intravenous route. The best results were obtained when both routes were combined, however. Animals given the genetically modified HSPCs via both forms of administration had lower disease severity scores than those treated through only one.

At about eight months after treatment, 86% of mice given both routes were still alive and more than three-quarters (76%) lived past a year without displaying any Batten-like symptoms.

The combinatorial transplant strategy could achieve greater clinical benefit than the individual approaches, the researchers wrote, noting that also tended to result in less variable outcomes.

Tissue analyses of the mices brain and spinal cord suggested an increase in PPT1 levels with the treatment, in many cases to levels higher than those seen in healthy mice. Again, the highest enzyme levels were achieved with the combination strategy.

Data also suggested the stem cell treatment reduced neuroinflammation.

In all these experiments, treatment was administered early in life, before the mice displayed Batten-like symptoms. In subsequent tests, the researchers gave the modified HSPCs only when the mice were about 4 months old, when symptoms start becoming apparent in this model.

We decided to treat with the [genetically engineered HSPCs] at onset of symptoms to verify whether we could achieve therapeutic benefit also in a stage of the disease when damage has already accumulated in the brain and spinal cord, the researchers wrote.

The treatment diminished disease severity and extended survival also in this context 80% of treated mice versus none of the untreated mice were alive at eight months.

The combined administration approach of modified HSPCs results in the most robust therapeutic benefit among the tested approaches on both presymptomatic [before symptoms] as well as symptomatic animals, since it resulted in complete abrogation of the disease in a clinically relevant mouse model and determined a long-lasting and thorough prevention of symptoms, the researchers wrote.

Notably, this same approach could uniquely benefit adult symptomatic animals, a finding of utmost importance for translation purposes, the researchers wrote, adding the clinical translatability of our strategy is further supported by the favorable safety profile we showed here.

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Modified stem cell therapy extends survival in infantile Batten... - Batten Disease News