Arthritis: The Latest on Joint Replacement, Repair, and New … – Healthline

For the millions of Americans who live with arthritis (inflammation of the joints that can affect one or multiple joints), the condition can significantly impact ones quality of life.

For those who have osteoarthritis, the degenerative disease is caused by the regular mechanical wear-and-tear on the joints over time. Those who have rheumatoid arthritis find the autoimmune disease causing pain and inflammation throughout their body, with their own immune systems attacking the tissue lining in their joints.

Arthritis can affect ones ability to get around easily, perform common everyday tasks, and simply live in comfort without inflammation and pain.

About 24% of all adults in the United States have arthritis, which is a leading cause of work disability, leading to a total annual cost of wages lost and escalating medical bills totaling $303.5 billion, according to the Centers for Disease Control and Prevention (CDC).

Many may have to turn to joint repair and replacement procedures as a way to treat their arthritis. Its so common that about 790,000 total knee replacements and 450,000 hip replacements are performed each year in the U.S., a number that will only keep growing as the nations population ages, reports the American College of Rheumatology.

To address this need, a range of technological innovations and advancements in treatment have emerged in recent years to create more long-lasting, effective treatments to repair joints affected by arthritis.

Healthline spoke with experts about the latest advancements from growing new cartilage cells to using injectables to spur more efficient healing in joint repair for arthritis, and whats next as we look to the future of the field.

When asked to assess the overall state of the field of joint repair and replacement, Dr. Susan Goodman, an attending rheumatologist at the Hospital for Special Surgery in New York, said she believes we are looking at a future with no need for joint replacements.

But to get to that point, she told Healthline that there are several significant hurdles ahead.

For a condition such as rheumatoid arthritis [RA], the problem of joint damage develops from the unchecked inflammation that erodes cartilage. For patients with RA, it is critical to control the inflammatory disease so that the new or engineered cartilage doesnt get damaged in the same way, Goodman said. For the time being, since artificial/engineered tissue has only been used in small areas of the damaged joint, it would not be a solution for patients with inflammatory arthritis who have abnormalities in their entire joint.

When it comes to joints like the knee, which are very susceptible to mechanical forces of weight and impact, a condition like obesity will also lead to damage in the engineered joint.

Dr. Kristofer Jones, a board-certified, fellowship-trained orthopedic surgeon who specializes in sports-related musculoskeletal injuries of the knee, shoulder, and elbow, told Healthline that we are ahead of where we were 10 to 15 years ago and a lot of new research has come out along with a lot of new products that look at alternative ways to resurface new cartilage, with either a patients own cells or using allograft tissue, or transplanted tissue between patients.

The research shows these new tissue types are certainly durable and provide patients with long-lasting pain relief, but the issue is the progression of joint degeneration in other areas of the knee, Jones added.

He said its not uncommon to have performed a cartilage transplant procedure to address one part of the knee and then two or three years later see the same patient experience degeneration in other areas, with new symptoms.

We are good right now at resurfacing small-to-medium size lesions with the durable tissue, but we havent quite figured out how to turn off the button that has started in some of these patients where you are looking at progressive joint degeneration in other areas, Jones explained.

From his perspective, Dr. Sid Padia, a specialist in vascular and interventional radiology at UCLA Medical Center, told Healthline that, in general, there really has been no significant impact or change in the standard of care for patients with joint disease.

Theres been no seismic shift reorienting how we view the treatment of people with joint disease, but there have been several promising and new therapies that have shown potential benefits in the treatment of various joint diseases. That being said, much of these potential new therapies currently being studied have not come to fruition with respect to long term clinical benefit, he said.

Many of the new minimally invasive therapies have shown in studies or have shown short term benefit and thats because these studies have not assessed long-term outcomes and have not compared it [the given procedure] to a control group, so its hard for the medical community to really accept these new treatment options, Padia added. So, I think there is a tremendous opportunity for a breakthrough treatment simply because in many of these patients, the treatment options are still quite limited.

Jones said one of the current advancements that stands out the most to him is the use of biologic injectables, or orthobiologics.

These are injectable substances used by orthopaedic surgeons to help your injuries heal more quickly. They can be used for tendons, ligaments, and broken bones, for example, and are derived from substances that naturally occur in your body, according to the American Academy of Orthopaedic Surgeons.

Jones cited injectable therapies like those using platelet-rich plasma (PRP), where the plasma is injected right into a tissue, and bone marrow aspirate concentrate, which uses bone marrow cells, as two examples.

PRP, bone marrow aspirate concentrate, amniotic suspension allograft injections these are all things that we are studying to determine how we can best utilize them to treat patients who have knee pain from arthritis, he said.

Jones explained that many of these injectable therapies that are being developed are to augment surgical procedures to move the healing process along and also better create more favorable cell homeostasis so further joint degeneration doesnt happen.

He said we can expect to see a lot more of these kinds of injections available in the coming years to treat symptomatic knee pain. Jones cited a Phase III trial for which he is the principal investigator at UCLA.

At UCLA we have this Phase III FDA trial that is looking at one of these products, the trial ended and we are currently crunching the numbers to look at the data to see if there are no adverse patient events, he said.

At UCLA, Padia has been working on an alternative to knee replacement that could offer pain relief to those individuals who might not be candidates for surgery.

You might not qualify for knee surgery due to a medical complication that puts you at high risk or if you are at advanced age, for instance. Younger people might also delay surgery due to the fact theyll ultimately need another knee replacement surgery or procedure within the next 20 years.

The procedure is called genicular artery embolization. Its a minimally invasive procedure during which particles that are smaller than grains of sand are injected by way of a small catheter into enlarged knee arteries. This only takes two hours to perform and you can head home the same day and return to regular physical activities later that day.

Weve published our results, done randomized trials that show genicular artery embolization in the knee can lead to reduction in pain and weve adapted this procedure for people with tennis elbow, which is something fairly common in people who play racket sports, Padia explained. Given the increase in the use of pickleball, we are starting to see a lot more people with tennis elbow.

He added that treating something like tennis elbow is fairly limited and surgical correction is rarely done. As a result, steroid injections are often the mainstay treatment for this condition, offering a short-term benefit.

People are often left with no other option than to quit their physical activity, so weve developed this procedure for tennis elbow and its had a very promising effect in people, he said.

A 2022 study in the journal Advanced Functional Materials highlights research out of Duke University that shed light on what was described as the first synthetic gel-based substitute for cartilage.

The researchers behind this gel say it can be pulled and pressed with more force and weight than naturally occurring cartilage. This substance is also three times more resistant to the regular wear and tear that often fuels osteoarthritis and joint pain.

A company called Sparta Biomedical is developing this hydrogel product and testing them on sheep, with human clinical trials expected to start this year, according to a press release.

To put in perspective how powerful this material is, natural cartilage can handle 5,800 to 8,500 pounds per inch of tugging and squishing before hitting its breaking point. The hydrogel is reportedly 26% stronger than natural cartilage in suspension and 66% stronger in compression, reads the release.

When asked what is exciting to him in the field outside of surgery right now, Jones pointed to synthetic forms of cartilage that are as durable if not more durable than the real thing.

We are a little further away from seeing that being used clinically, the issue is trying to figure out how to get those different synthetic tissue types to adhere to bone and be durable for the long term, Jones explained. That may be something that down the line is a possible alternative to traditional joint replacement. The whole point of all of this is to preserve your joint and the natural feel for it.

In late 2022, research from The Forsyth Institute was published in the journal Science Advances, pointing to a potential mechanism for generating new cartilage cells.

The goal of this study was to figure out how to regenerate cartilage. We wanted to determine how to control cell fate, to cause the somatic cell to become cartilage instead of bone, Dr. Takamitsu Maruyama of Forsyth said in a release.

The research contributes to a growing body of research that suggests future of joint repair to treat arthritis might be at the cellular level.

I think the greatest potential [for the future] are the use of stem cells, Padia said. The use of stem cells is, number one, a relatively straightforward minimally invasive procedure. It does have the potential to have significant impact on people with joint diseases. The key is there needs to be an appropriate and accurate way to select the ideal patients who benefit from a stem cell treatment, there needs to be comparative studies ideally with a placebo studies conducted with adequate amount of time for long-term results.

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Arthritis: The Latest on Joint Replacement, Repair, and New ... - Healthline

2023 Stem Cell Therapy Market Key Trends: Dynamics Shaping the … – Digital Journal

PRESS RELEASE

Published April 11, 2023

Stem Cell Therapy Market Report 2023 | 125 Pages Latest Research | provides all-inclusive update on growth segments, recent developments of top players [Ernst & Young, Aon Consulting, McKinsey & Company, Accenture, PriceWaterhouseCoopers (PwC), Affiliated Computer Services, KPMG Consulting] with their revenue and CAGR status. It also covers various marketing strategies of top manufacturers.

"Final Report will add the analysis of the impact of COVID-19 on this industry."

Global Stem Cell Therapy Market Report 2023-2028 is a comprehensive analysis of the latest trends and opportunities in the industry. The report presents a detailed assessment of the market size, growth factors, and demand status, as well as the challenges and risks faced by businesses across all geographic regions. It also features the latest technological advancements, SWOT, and PESTLE analysis, providing a holistic overview of the industry's competitive landscape and regional segments. This insightful report covers key players profiling with their company profiles, supply-demand scope, and global trending technologies.

Additionally, Stem Cell Therapy market (125 Pages) report is a valuable addition to any company's future strategies and path forward, as it offers a deep understanding of the industry revenue and competitive landscape. With its precise information and thoughtful analysis, the report provides businesses with the necessary tools to make informed decisions and stay ahead of the competition.

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The global Stem Cell Therapy market size was valued at USD 12932.56 million in 2022 and is expected to expand at a CAGR of 8.2% during the forecast period, reaching USD 20753.25 million by 2028.Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions, diabetes, heart disease, and other conditions.With the ability of scientists to isolate and culture embryonic stem cells, and with scientists' growing ability to create stem cells using somatic cell nuclear transfer and techniques to create induced pluripotent stem cells, controversy has crept in, both related to abortion politics and to human cloning. Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial.

Key Players covered in the global Stem Cell Therapy Market are:

The report focuses on the Stem Cell Therapy market size, segment size (mainly covering product type, application, and geography), competitor landscape, recent status, and development trends. Furthermore, the report provides detailed cost analysis, supply chain. Technological innovation and advancement will further optimize the performance of the product, making it more widely used in downstream applications. Moreover, Consumer behavior analysis and market dynamics (drivers, restraints, opportunities) provides crucial information for knowing the Stem Cell Therapy market.

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Most important types of Stem Cell Therapy products covered in this report are:

Most widely used downstream fields of Stem Cell Therapy market covered in this report are:

Key Takeaways from the Global Stem Cell Therapy Market Report:

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Following Chapter Covered in the Stem Cell Therapy Market Research:

Chapter 1 mainly defines the market scope and introduces the macro overview of the industry, with an executive summary of different market segments ((by type, application, region, etc.), including the definition, market size, and trend of each market segment.

Chapter 2 provides a qualitative analysis of the current status and future trends of the market. Industry Entry Barriers, market drivers, market challenges, emerging markets, consumer preference analysis, together with the impact of the COVID-19 outbreak will all be thoroughly explained.

Chapter 3 analyzes the current competitive situation of the market by providing data regarding the players, including their sales volume and revenue with corresponding market shares, price and gross margin. In addition, information about market concentration ratio, mergers, acquisitions, and expansion plans will also be covered.

Chapter 4 focuses on the regional market, presenting detailed data (i.e., sales volume, revenue, price, gross margin) of the most representative regions and countries in the world.

Chapter 5 provides the analysis of various market segments according to product types, covering sales volume, revenue along with market share and growth rate, plus the price analysis of each type.

Chapter 6 shows the breakdown data of different applications, including the consumption and revenue with market share and growth rate, with the aim of helping the readers to take a close-up look at the downstream market.Chapter 7 provides a combination of quantitative and qualitative analyses of the market size and development trends in the next five years. The forecast information of the whole, as well as the breakdown market, offers the readers a chance to look into the future of the industry.

Chapter 8 is the analysis of the whole market industrial chain, covering key raw materials suppliers and price analysis, manufacturing cost structure analysis, alternative product analysis, also providing information on major distributors, downstream buyers, and the impact of COVID-19 pandemic.

Chapter 9 shares a list of the key players in the market, together with their basic information, product profiles, market performance (i.e., sales volume, price, revenue, gross margin), recent development, SWOT analysis, etc.

Chapter 10 is the conclusion of the report which helps the readers to sum up the main findings and points.

Chapter 11 introduces the market research methods and data sources.

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The report delivers a comprehensive study of all the segments and shares information regarding the leading regions in the market. This report also states import/export consumption, supply and demand Figures, cost, industry share, policy, price, revenue, and gross margins.

Client Focus:

Yes. As the COVID-19 and the Russia-Ukraine war are profoundly affecting the global supply chain relationship and raw material price system, we have definitely taken them into consideration throughout the research

With the aim of clearly revealing the competitive situation of the industry, we concretely analyze not only the leading enterprises that have a voice on a global scale, but also the regional small and medium-sized companies that play key roles and have plenty of potential growth.

Both Primary and Secondary data sources are being used while compiling the report.

Primary sources include extensive interviews of key opinion leaders and industry experts (such as experienced front-line staff, directors, CEOs, and marketing executives), downstream distributors, as well as end-users.

Secondary sources include the research of the annual and financial reports of the top companies, public files, new journals, etc. We also cooperate with some third-party databases.

Yes. Customized requirements of multi-dimensional, deep-level and high-quality can help our customers precisely grasp market opportunities, effortlessly confront market challenges, properly formulate market strategies and act promptly, thus to win them sufficient time and space for market competition.

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Detailed TOC of Stem Cell Therapy Market Forecast Report 2023-2028:

1 Stem Cell Therapy Market Overview

1.1 Product Overview and Scope of Stem Cell Therapy Market

1.2 Stem Cell Therapy Market Segment by Type

1.2.1 Global Stem Cell Therapy Market Sales Volume and CAGR (%) Comparison by Type (2018-2028)

1.3 Global Stem Cell Therapy Market Segment by Application

1.3.1 Stem Cell Therapy Market Consumption (Sales Volume) Comparison by Application (2018-2028)

1.4 Global Stem Cell Therapy Market, Region Wise (2018-2028)

1.5 Global Market Size of Stem Cell Therapy (2018-2028)

1.5.1 Global Stem Cell Therapy Market Revenue Status and Outlook (2018-2028)

1.5.2 Global Stem Cell Therapy Market Sales Volume Status and Outlook (2018-2028)

1.6 Global Macroeconomic Analysis

1.7 The impact of the Russia-Ukraine war on the Stem Cell Therapy Market

2 Industry Outlook

2.1 Stem Cell Therapy Industry Technology Status and Trends

2.2 Industry Entry Barriers

2.2.1 Analysis of Financial Barriers

2.2.2 Analysis of Technical Barriers

2.2.3 Analysis of Talent Barriers

2.2.4 Analysis of Brand Barrier

2.3 Stem Cell Therapy Market Drivers Analysis

2.4 Stem Cell Therapy Market Challenges Analysis

2.5 Emerging Market Trends

2.6 Consumer Preference Analysis

2.7 Stem Cell Therapy Industry Development Trends under COVID-19 Outbreak

2.7.1 Global COVID-19 Status Overview

2.7.2 Influence of COVID-19 Outbreak on Stem Cell Therapy Industry Development

3 Global Stem Cell Therapy Market Landscape by Player

3.1 Global Stem Cell Therapy Sales Volume and Share by Player (2018-2023)

3.2 Global Stem Cell Therapy Revenue and Market Share by Player (2018-2023)

3.3 Global Stem Cell Therapy Average Price by Player (2018-2023)

3.4 Global Stem Cell Therapy Gross Margin by Player (2018-2023)

3.5 Stem Cell Therapy Market Competitive Situation and Trends

3.5.1 Stem Cell Therapy Market Concentration Rate

3.5.2 Stem Cell Therapy Market Share of Top 3 and Top 6 Players

3.5.3 Mergers and Acquisitions, Expansion

4 Global Stem Cell Therapy Sales Volume and Revenue Region Wise (2018-2023)

4.1 Global Stem Cell Therapy Sales Volume and Market Share, Region Wise (2018-2023)

4.2 Global Stem Cell Therapy Revenue and Market Share, Region Wise (2018-2023)

4.3 Global Stem Cell Therapy Sales Volume, Revenue, Price and Gross Margin (2018-2023)

4.4 United States Stem Cell Therapy Sales Volume, Revenue, Price and Gross Margin (2018-2023)

4.4.1 United States Stem Cell Therapy Market Under COVID-19

4.5 Europe Stem Cell Therapy Sales Volume, Revenue, Price and Gross Margin (2018-2023)

4.5.1 Europe Stem Cell Therapy Market Under COVID-19

4.6 China Stem Cell Therapy Sales Volume, Revenue, Price and Gross Margin (2018-2023)

4.6.1 China Stem Cell Therapy Market Under COVID-19

4.7 Japan Stem Cell Therapy Sales Volume, Revenue, Price and Gross Margin (2018-2023)

4.7.1 Japan Stem Cell Therapy Market Under COVID-19

4.8 India Stem Cell Therapy Sales Volume, Revenue, Price and Gross Margin (2018-2023)

4.8.1 India Stem Cell Therapy Market Under COVID-19

4.9 Southeast Asia Stem Cell Therapy Sales Volume, Revenue, Price and Gross Margin (2018-2023)

4.9.1 Southeast Asia Stem Cell Therapy Market Under COVID-19

4.10 Latin America Stem Cell Therapy Sales Volume, Revenue, Price and Gross Margin (2018-2023)

4.10.1 Latin America Stem Cell Therapy Market Under COVID-19

4.11 Middle East and Africa Stem Cell Therapy Sales Volume, Revenue, Price and Gross Margin (2018-2023)

4.11.1 Middle East and Africa Stem Cell Therapy Market Under COVID-19

5 Global Stem Cell Therapy Sales Volume, Revenue, Price Trend by Type

5.1 Global Stem Cell Therapy Sales Volume and Market Share by Type (2018-2023)

5.2 Global Stem Cell Therapy Revenue and Market Share by Type (2018-2023)

5.3 Global Stem Cell Therapy Price by Type (2018-2023)

5.4 Global Stem Cell Therapy Sales Volume, Revenue and Growth Rate by Type (2018-2023)

6 Global Stem Cell Therapy Market Analysis by Application

6.1 Global Stem Cell Therapy Consumption and Market Share by Application (2018-2023)

6.2 Global Stem Cell Therapy Consumption Revenue and Market Share by Application (2018-2023)

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2023 Stem Cell Therapy Market Key Trends: Dynamics Shaping the ... - Digital Journal

Research identifies new target that may prevent blood cancer – VUMC Reporter

Alexander Bick, MD, PhD

by Bill Snyder

An international coalition of biomedical researchers co-led by Alexander Bick, MD, PhD, at Vanderbilt University Medical Center has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients risk of blood cancer.

The technique, called PACER, led to the identification of a gene that, when activated, drives clonal expansion. The findings, published April 12 in the journal Nature, suggest that drugs targeting this gene, TCL1A, may be able to suppress clonal growth and associated cancers.

We think that TCL1A is a new important drug target for preventing blood cancer, said Bick, the studys co-corresponding author with Stanford Universitys Siddhartha Jaiswal, MD, PhD.

More than 10% of older adults develop somatic (non-inherited) mutations in blood stem cells that can trigger explosive, clonal expansions of abnormal cells, increasing the risk for blood cancer and cardiovascular disease.

Since arriving at VUMC in 2020, Bick, assistant professor of Medicine in the Division of Genetic Medicine and director of the Vanderbilt Genomics and Therapeutics Clinic, has contributed to more than 30 scientific papers that are revealing the mysteries of clonal growth (hematopoiesis).

With age, dividing cells in the body acquire mutations. Most of these mutations are innocuous passenger mutations. But sometimes, a mutation occurs that drives the development of a clone and ultimately causes cancer.

Prior to this study, scientists would measure clonal growth rate by comparing blood samples taken decades apart. Bick and his colleagues figured out a way to determine the growth rate from a single timepoint, by counting the number of passenger mutations.

You can think of passenger mutations like rings on a tree, Bick said. The more rings a tree has, the older it is. If we know how old the clone is (how long ago it was born) and how big it is (what percentage of blood it takes up), we can estimate the growth rate.

The PACER technique for determining the passenger-approximated clonal expansion rate was applied to more than 5,000 individuals who had acquired specific, cancer-associated driver mutations in their blood stem cells, called clonal hematopoiesis of indeterminate potential or CHIP, but who did not have blood cancer.

Using a genome-wide association study, the investigators then looked for genetic variations that were associated with different clonal growth rates. To their surprise, they discovered that TCL1A, a gene which had not previously been implicated in blood stem cell biology, was a major driver of clonal expansion when activated.

The researchers also found that a commonly inherited variant of the TCL1A promoter, the DNA region which normally initiates transcription (and thus activation) of the gene, was associated with a slower clonal expansion rate and a markedly reduced prevalence of several driver mutations in CHIP, the second step in the development of blood cancer.

Experimental studies demonstrated that the variant suppresses gene activation.

Some people have a mutation that prevents TCL1A from being turned on, which protects them from both faster clone growth and from blood cancer, Bick said. Thats what makes the gene so interesting as a potential drug target.

The research is continuing with the hope of identifying additional important pathways relevant to precancerous growth in other tissues as well as blood, he added.

Researchers from more than 50 institutions across the United States, as well as Germany, Sweden and the Netherlands participated in the study. Other VUMC co-authors were Taralyn Mack, Benjamin Shoemaker, MD, MSCI, and Dan Roden, MD.

The research at VUMC is supported by National Institutes of Health grant OD029586, a Burroughs Wellcome Fund Career Award for Medical Scientists, the E.P. Evans Foundation & RUNX1 Research Program, a Pew-Stewart Scholar for Cancer Research Award, the VUMC Brock Family Endowment, and a Young Ambassador Award from the Vanderbilt-Ingram Cancer Center.

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Research identifies new target that may prevent blood cancer - VUMC Reporter

Association between birth by caesarian section and anxiety, self … – BMC Psychiatry

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