CAR-T Cell Therapy Completely Cures Autoimmune Disease in Several Patients – Inside Precision Medicine

Researchers at Friedrich-Alexander-University Erlangen-Nrnberg (FAU), in Germany have successfully cured several patients suffering from severe systemic lupus erythematosus (SLE) using genetically modified immune cells known as CAR-T cells.

CAR T cells are immune cells taken from an individual patient and genetically engineered to express proteins known as CARchimeric antigen receptorson their surface in order to bind specific proteins on the surface of target cells and eliminate them. CAR-T cells are a form of personalized therapy and already approved as a treatment for several cancers in the U.S.

In the first study of its kind, published in Nature Medicine, researchers at FAU have now modified CAR T cells to attack immune cells known as B cells which produce harmful antibodies against the bodys own cells in autoimmune diseases such as SLE, with astonishing results.

We have been able to help six young patients who were suffering from a life-threatening form of SLE and cure them of the disease completely by treating them with CAR-T cells, said Prof. Georg Schett, PhD, director of the Department of Medicine at FAU and senior author of the study in a press statement.

SLE is a severe form of autoimmune disease in which immune cells form antibodies that attack the bodys own DNA leading to the inflammation of internal organs. Patients suffering from the disease are often dependent on immunosuppressive drugs in order to manage the symptoms such as extreme fatigue and joint pain. For their trial, the researchers recruited treatment-resistant SLE patients with all trial participants showing damage in multiple organs, such as the kidneys, heart and lungs.

What is special about this is that a single infusion of CAR-T cells brought down the inflammation and autoimmune response like a house of cards, and the patients were able to stop all therapy including corticosteroids, said Schett.

The researchers compared the treatment to pressing a reset button in the immune system. According to Prof. Dimitros Mougiakakos, PhD, director of the department of hematology, oncology and stem cell transplantation at the University of Magdeburg and co-author of the study, 100 days after CAR T cell therapy the B cells returned but the disease continued to stay away.

When the immune system of treated patients is examined, it is surprising that the newly-emerged B cells are naive, similar to a baby. We can therefore be confident is saying that a reset button really has been pressed here, said Prof. Gerhard Krnke, PhD, professor of translational immunology at FAU and co-author of the study in a press statement.

However, due to not only diseased but all B-cells being eliminated, CAR T cell therapy carries a risk of causing cytokine release syndrome in which T cells produce pro-inflammatory molecules known as cytokines into the bloodstream, thus making the therapy potentially unsuitable for patients with only mild symptoms.

To ensure the CAR T cell therapy didnt harm the immune system of the patients in the trial, the researchers tested their antibody amounts in response to several vaccines such as measles, mumps and hepatitis B before and after the treatment. Overall, they didnt find a significant difference in antibody titers concluding that the CAR T cells mainly destroy the disease-causing B-cells producing autoantibodies.

As a next step the scientists at FAU are planning to conduct a larger basket clinical trial, where patients with different kinds of severe autoimmune diseases will receive CAR T cell therapy.

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CAR-T Cell Therapy Completely Cures Autoimmune Disease in Several Patients - Inside Precision Medicine

Biopreservation Market worth USD 9.5 Billion by 2030, says Global Market Insights Inc. – GlobeNewswire

Selbyville, Delaware, Sept. 26, 2022 (GLOBE NEWSWIRE) --

The biopreservation market value is anticipated to cross USD 9.5 billion in revenue by 2030, according to a new research report by Global Market Insights Inc.

Increasing demand for regeneration medicines due to rising occurrences of lifestyle diseases will drive the industry trends. Growing need for effective healthcare systems, along with prominent healthcare expenditure, will increase the demand for biopreservatives. The soaring cases of chronic diseases among the elderly population have encouraged government agencies to spend massively on healthcare, pushing gene banks, bio banks and hospitals to focus on biopreservation.

Request for a sample of this research report @ https://www.gminsights.com/request-sample/detail/762

Wide applicability in research laboratories to push the industry landscape

Biopreservation market from equipment segment was valued at over USD 3.5 billion in 2021, due to the growing demand for biopreservation equipment to preserve blood, vaccines, and more, in hospitals and laboratories. The equipment includes freezers, refrigerators, consumables, and liquid nitrogen and are widely utilized in DNA, stem cell, plasma, and tissue research sectors.

CD34+ cell provider segment to foster market expansion

The CD34+ segment was worth more than USD 810 million in 2021. This is attributed to the prevalent use of cell surface marker CD34+ for the diagnosis of hematopoietic stem cells that can differentiate into multiple lineages. Blood from newborns umbilical cords is a crucial source of these cells. Notable advancements in stem cell research will stimulate product penetration.

Browse key industry insights spread across 260 pages with 413 market data tables & 13 figures & charts from the report, Biopreservation Market Analysis By Product (Equipment {Freezers, Refrigerators, Consumables [Vials, Straws, Microtiter, Bags], Liquid Nitrogen}, Media {Pre-formulated, Home-brew}, Laboratory Information Management System [LIMS]), By Application (Regenerative Medicine {Cell Therapy, Gene Therapy}, Biobanking {Human Eggs, Human Sperm, Veterinary IVF}, Drug Discovery), By Cell Provider (CD34+, CD19+, MSC, iPSC, hESC, Tumor Cells), Industry Analysis Report, Regional Outlook Growth Potential, Competitive Market Share & Forecast, 2022 2030 in detail along with the table of contents:

https://www.gminsights.com/industry-analysis/biopreservation-market

High demand for advanced storage facility to boost industry size

Biopreservation market from regenerative medicine segment accounted USD 1 billion in 2021. owing tothe rising demand for advancedbio storage facilities. Intensifying demand for regenerative therapies that require regenerative medicines will propel the demand for effective bio-storage procedures. For instance, in September 2022, CIRM provided around $2.7 million to UCI to establish a regenerative medicine training program to spread awareness regarding its benefits.

North America to emerge as a prominent regional market due to surging incidences of chronic diseases

North America biopreservation market held a substantial industry share of more than 45% in 2021 and is slated to depict significant growth over the assessment timeframe. Exponential demand for diagnosis of chronic diseases may be a key factor pushing regional market revenue. In addition, government guidelines supporting ethical usage of biological samples and the development of novel drugs & therapies in the healthcare space will foster the North America industry outlook.

Effective expansion plans to remain a vital development strategy for industry players

The competitive landscape of the biopreservation market is inclusive of Arctiko A/S, Thermo Fisher Scientific Inc, PHC Holdings Corporation, Cryport, Inc, Eppendorf AG, Helmer Scientific, VWR International (Avantor, Inc.), Biolife Solutions, Azenta, and Merck KGaA. These companies primarily focus on research and development and enter into strategic mergers and collaborations to proliferate their market position.

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About Global Market Insights

Global Market Insights Inc., headquartered in Delaware, U.S., is a global market research and consulting service provider, offering syndicated and custom research reports along with growth consulting services. Our business intelligence and industry research reports offer clients with penetrative insights and actionable market data specially designed and presented to aid strategic decision making. These exhaustive reports are designed via a proprietary research methodology and are available for key industries such as chemicals, advanced materials, technology, renewable energy, and biotechnology.

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Biopreservation Market worth USD 9.5 Billion by 2030, says Global Market Insights Inc. - GlobeNewswire

A glimpse into Indian consumers expectations for cosmetic treatments and consumption insights – The Financial Express

By Dr Chytra V Anand

The fascination with beauty and skincare in India has grown leaps and bounds in recent times, and understandably so, given that the culture of beauty is deeply rooted in the country. The days when beauty was an aspect of social class and the cosmetic treatments and products you access gave away your economic status are long gone, as are the days when cosmetic treatments were considered a girl thing. With cosmetic treatments becoming more accessible and sought-after, the Indian skincare and derma cosmetics market generated an estimated revenue of a whopping USD 188.2 million in 2021. The same is projected to grow at a CAGR of 10.2% between 2021 and 2030.

Today, with changing lifestyles, demographic growth, cutting-edge technology, and improving economic and social conditions thanks to rising per capita and disposable income, India is quickly heading towards becoming a leader in the global cosmetics industry. But for a bit of self-introspection, what are Indian consumers looking for when it comes to cosmetic treatments? What does their consumption tell industry players?

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Body hair removal has become one of the most popular cosmetic procedures done across the world today. But compared to shaving, waxing, or using an epilator or a trimmer, laser hair removal is a more permanent hair removal method that has gained immense traction of late. Especially in urban India, laser hair removal has quickly gained popularity, with mothers even bringing their 16-year-olds for Laser hair removal.

In 2021, the global laser hair removal market was valued atUSD 798.6 million, with an estimated CAGR of 18.4% from 2022 to 2030. Given that laser hair removal is a one-time procedure, although one has to sit through multiple sessions, the results, when done by a reliable cosmetic professional, are impressive. The Asia Pacific is projected to be the fastest-growing segment for laser hair removal, especially in countries like India and China.

A cosmetic procedure where a chemical solution is applied to your skin to remove the top layers, Chemical Peels ensure that the skin becomes smoother and clearer, making it radiant. On the other hand, a Medical Clean-up, in the simplest terms, is the procedure of cleaning your skin, ridding impurities like blackheads and white head spots to clear clogged pores. Besides, Medical Clean-ups are also beneficial for people struggling with acne scars, making it a popular procedure that an increasing number of people are choosing. For Chemical Peels, the market size is expected to touch USD 68.81 million between 2021 to 2025, making their popularity surge.

As we grow older, our skin begins to age too, and wrinkles and fine lines begin to appear on our face. Cosmetic procedures like Hydra Facials and skin maintenance with Laser Photofacials are a weekly must-do for 30-45-year-olds to ensure their skin is supple and glowing. Apart from this, the perception of Indian consumers when it comes to cosmetic treatments like Botox and Fillers has begun to change. These are no longer viewed as taboo as people now realise that they give your skin a lift.

Such treatments are also no longer only available for a certain section of society, like the wealthy. Botox and Fillers are now available to everyone, and consumers are looking at them from a skin maintenance standpoint rather than as a luxury, unnecessary treatment. Annually, the Botox segment is registering 20-25% growth in the country proof of evolving consumer preferences and the rising popularity of such treatments. Besides these, derma cosmetics and medical skin care have also gained a fair amount of traction, with skincare aficionados looking for effective and efficient skin care procedures that are non-surgical.

Alongside our skincare, taking care of our mane is equally important. For people struggling with hair fall, flaky and dry scalp, and other issues that affect your hair, stem cell therapy is the answer. Often done annually, stem cell therapy helps rejuvenate your hair cells to retain hair and repair damage. And with the global hair restoration market standing at over USD 4.2 billion in 2020, we can safely say its here to stay.

With consumerism changing face gradually and Indian consumers gaining access to world-class cosmetic treatments that are non-surgical, which still trump surgical procedures, the future of the Indian cosmetic treatments market shines bright. As long as the procedures are done by qualified and experienced professionals and are reliable and effective, the demand for such cosmetic procedures will continue to grow.

(The author isfounder ofKosmoderma Healthcare Pvt. Ltd.Views expressed are personal and do not reflect the official position or policy of the FinancialExpress.com.)

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A glimpse into Indian consumers expectations for cosmetic treatments and consumption insights - The Financial Express

20220927 Seven New CSL Global Research Acceleration Initiative Awardees Announced – CSL Limited

MELBOURNE, AUSTRALIA - 27 September 2022:Seven medical researchers have been awarded a CSL Research Acceleration Initiative (RAI) partnership, including up to an AU$500,000 investment in each program over two years, to fast-track the discovery of innovative biotherapies to address unmet medical needs.

The CSL Research Acceleration Initiative establishes partnerships between CSL and global research organisations to accelerate commercialisation of promising discovery programs. In addition to creating long-term mutual partnerships to further innovation, the initiative includes funding as well as access to CSL R&D experts.

The seven Global RAI awardees, selected via the 2021 call for proposals, include researchers from: The University of Queensland, University of Newcastle and ANZAC Research Institute in Australia; University of Pennsylvania in the US; Justus Liebig University Giessen and University Hospital of Ludwig Maximilian University of Munich in Germany; and University of Basel in Switzerland.

Dr Marthe DOmbrain, CSLs Head of Global Research Innovation said, Through our Global Research Acceleration Initiative, we are able to tap into and support research innovation happening in all corners of the world. We are looking forward to collaborating with our new partners to support the development of their exciting discoveries.

These Global RAI awardees research addresses important unmet medical needs across CSLs therapeutic areas, including immunology, transplant, respiratory, hematology, and cardiovascular and metabolic disease.

The investigators and technologies selected in the 2021 call for proposals include:

Professor Allison Pettit, The University of Queensland, Australia Prof. Pettit is exploring a new therapeutic approach to improve homing and engraftment of hematopoietic stem cell transplants. Prof Pettits program aims to reduce graft failure and risk of infection, thus significantly improving outcomes for patients.

Dr Kirsten Coupland, University of Newcastle, Australia Dr. Coupland is researching novel therapeutic targets for acute ischemic stroke, one of the leading causes of mortality worldwide. Dr Couplands work focuses on understanding how the composition of cerebrospinal fluid changes following a stroke.

Associate Professor Georgina Clark, ANZAC Research Institute, Australia A/Prof. Clark is developing a new treatment that could reduce the requirement for chemotherapy during a hematopoietic stem cell transplant, thus improving safety and enabling more patients to benefit from this potentially curative approach.

Professor Daniel Rader, University of Pennsylvania, United States of America Prof. Rader is developing a novel therapy for reducing triglycerides (a type of fat) in the blood. Patients with very high triglycerides can develop severe and sometimes life-threatening pancreatitis.

Professor Elie El Agha, Justus Liebig University Giessen, Germany Prof. El Agha's research program is focused on novel cellular and molecular pathways implicated in the pathobiology of idiopathic pulmonary fibrosis; a progressive lung disease that currently has no cure.

Professor Arthur Liesz, University Hospital of Ludwig Maximilian University of Munich, Germany Prof. Liesz investigates the interplay between our immune system and the brain. Understanding the role the immune system plays in exacerbating cardiovascular events, including in acute ischemic stroke and myocardial infarction, may identify novel treatment approaches.

Professor Daniel Ricklin, University of Basel, Switzerland Prof. Ricklin is developing novel therapeutic candidates to target inflammation. This approach could be applied to many serious diseases including immune complex mediated autoimmune disorders.

Dr DOmbrain said that the RAI recipients research addresses important unmet medical needs where there is often limited or no existing treatment options available for patients. We want to look back in years to come and see projects accelerated via our Research Acceleration Initiative making a difference to the lives of patients across the globe.

We look forward to helping transform these ideas into what we hope will ultimately be ground-breaking therapies to improve the lives of people living with these conditions, said Dr DOmbrain.

Providing life-saving medicines to patients in over 100 countries, CSL is driven by its promise to advance and deliver innovations that address rare and serious diseases as well as protect public health. Each year, CSLs Global Research Acceleration Initiative works to identify promising research programs around the world which will benefit most from fast-tracked industry collaboration and support. More than 25 new partnerships have been established via the Research Acceleration Initiative since 2019.

For more information about the CSL Research Acceleration Initiative, please visit: http://www.csl.com/csl-rai

Media ContactKim ODonohue M: +61 449 884 603 E: kim.odonohue@csl.com.au

About CSL CSL Limited (ASX:CSL; USOTC:CSLLY) is a leading global biotechnology company with a dynamic portfolio of lifesaving medicines, including those that treat haemophilia and immune deficiencies, as well as vaccines to prevent influenza. Since our start in 1916, we have been driven by our promise to save lives using the latest technologies. Today, CSL including our three businesses, CSL Behring, CSL Seqirus and CSL Vifor provides lifesaving products to patients in more than 100 countries and employs 30,000 people. Our unique combination of commercial strength, R&D focus and operational excellence enables us to identify, develop and deliver innovations so our patients can live life to the fullest. For inspiring stories about the promise of biotechnology, visit CSLBehring.com/Vita and follow us on Twitter.com/CSL. For more information visit csl.com.

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20220927 Seven New CSL Global Research Acceleration Initiative Awardees Announced - CSL Limited

WHIM Syndrome: Market Analysis of Epidemiology, Pipeline Therapies, and Key Companies Working in the market – Digital Journal

WHIM Syndrome Market I

DelveInsights WHIM Syndrome Market Insights, Epidemiology, and Market Forecast2032 report delivers an in-depth understanding of the WHIM Syndrome, historical and forecasted epidemiology as well as the market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

DelveInsights WHIM Syndrome Market Insights, Epidemiology, and Market Forecast2032 report delivers an in-depth understanding of the WHIM Syndrome, historical and forecasted epidemiology as well as the market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

The WHIM Syndrome market report provides current treatment practices, emerging drugs, and their market share of the individual therapies, current and forecasted WHIM Syndrome symptoms market size from 2019 to 2032 segmented by seven major markets. The report also covers current WHIM Syndrome symptoms treatment practice/algorithm and unmet medical needs to curate the best opportunities. It assesses the underlying potential of the market.

Some of the key facts of the WHIM Syndrome Market Report:

Key benefits of the Whim Syndrome Market report:

With only symptomatic and no curative therapies approved in any markets, there exists a major unmet need for therapies that target the underlying cause of the disease to address the symptoms of WHIM Syndrome, to treat the patients effectively.

To counter unmet market needs and provide better treatment choices for WHIM Syndrome, several market players are working robustly either on single-agent novel molecules or on combination and dose modification of standard therapies. Several therapies are expected to be launched in the study period, likely to drive market growth during the study period.The major market players in WHIM Syndrome therapeutic market include X4 Pharmaceuticals, among others.

Got queries? Click here to know more about the Whim Syndrome Landscape

Whim Syndrome Market Overview

WHIM syndrome is a primary immunodeficiency disorder, one of a group of disorders characterized by irregularities in the cell development and/or cell maturation process of the immune system. The term WHIM is an acronym for the main signs of the syndrome: warts, hypogammaglobulinemia, infections, and myelokathexis. It is an autosomal-dominant combined immunodeficiency disease caused by mutations in the receptor CXCR4, resulting in increased bone marrow retention and severe reduction in circulating neutrophils.

WHIM Syndrome Diagnosis and Treatment

The treatment for WHIM syndrome can be mainly categorized into two categories: curative treatment and symptomatic treatment. Hematopoietic stem cell transplantation (allogenic) is the only available curative treatment for WHIM syndrome, whereas the symptomatic treatment involves the exogenous administration of immunoglobulins (IV/subcutaneous), G-CSF, and CXCR4 antagonists. Few major unmet needs in the market include no approved therapies, challenges in current symptomatic treatment options, challenges in hematopoietic stem cell transplantation (HSCT), lack of universal diagnostic criteria, and complicated diagnosis of the condition.

Whim Syndrome Market Epidemiological Insight

Whim Syndrome Market Epidemiological Segmentation

Whim Syndrome Market Outlook

The reports WHIM Syndrome market outlook helps to better understand the historic, current, and forecasted WHIM Syndrome market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers, and demand for better technology.

This segment gives a thorough detail of WHIM Syndrome market trend of each marketed drug and early-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to view the market at first sight.

According to DelveInsight, the WHIM Syndrome market in 7MM is expected to grow steadily during the study period 20192032.

The current management options for WHIM syndrome can be mainly categorized into two categories: curative treatment and symptomatic treatment. Hematopoietic stem cell transplantation (allogenic) is the only available curative treatment for WHIM syndrome, whereas the symptomatic treatment involves administration of granulocyte-colony stimulating factor (G-CSF), exogenous administration of immunoglobulins (IV/subcutaneous), G-CSF, and CXCR4 antagonists.

The major market players in WHIM Syndrome therapeutic market are Amgen, Sandoz (Novartis), Pfizer, Takeda, and X4 Pharmaceuticals, among others.

Learn more by requesting for sample @WHIM Syndrome Market Landscape

WHIM Syndrome Key Companies

WHIM Syndrome Therapies

Table of Contents

Click here to read more about WHIM Syndrome Market

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WHIM Syndrome: Market Analysis of Epidemiology, Pipeline Therapies, and Key Companies Working in the market - Digital Journal

Insights on the Biobanks Global Market to 2027 – Regenerative Medicine Applications for Biobanking Market will Drive Growth – ResearchAndMarkets.com -…

DUBLIN--(BUSINESS WIRE)--The "Biobanks Market - Global Industry Size, Share, Trends, Competition, Opportunity and Forecast, 2017-2027 Segmented By Type, By Sample Type, By Application, By End User, By Region" report has been added to ResearchAndMarkets.com's offering.

The Global Biobanks Market stood at USD40.70 billion in 2021 and is expected to grow at an impressive rate of 8.22% during the forecast period. This can be ascribed to the growing investments and research & development in advanced therapies such as cancer genomic studies, personalized medicine, among others.

Biobanks play a pivotal role in disease diagnosis and development of a treatment or drug. The COVID-19 pandemic crisis has significantly increased the demand for biobanks worldwide. During the pandemic crisis various new specialized biobanks, focusing on COVID-19 were developed for research & development activities. For instance, in July 2021, Tulane University announced a new COVID-19 biobank containing blood & cell samples from survivors.

Regenerative Medicine Applications for Biobanking Market will drive the Market

Biobanks Market contributes to the advancement of biomedical and translational research by collecting and preserving biological samples such as blood, tissues, and nucleic acids, which are then made available for use in research to discover disease-relevant biomarkers; this information is then used for diagnosis, prognosis, and drug response prediction.

The increase in the number of research activities in this area is a major market driver. The availability of government financing for regenerative medicine, stem cell treatments, and cell and gene therapy are fueling this segment's research. Aside from that, the growing trend of cord blood banking will help this market segment develop. Future possibilities are predicted to include breakthroughs in orthopaedic therapies utilising stem cells.

Stakeholders Shifting Focus from Sample-driven to Data-driven Strategies

Precision medicine research is gaining traction as a result of the digital revolution. Precision medicine research and clinical data are also inextricably linked. Although there are times when there are modest connections between the two variables. Because the availability of data on well-characterized and high-quality samples is of relevance to healthcare organizations, this works as a profitable opportunity for stakeholders in the biobanking market.

Artificial intelligence (AI) and big data analytics are being introduced into the biobanking landscape in order to develop strong correlations between precision medicine research and clinical data. This has aided faster research, which has had a positive impact on the delivery of new pharmaceuticals in the healthcare industry. As a result, there is a growing demand in the biobanking industry for increased informatics capabilities.

Demand for Temperature Control Systems to Gain Strength in Biobanks Market

Biobanks are in high demand to preserve a variety of biospecimen, from blood to tissues, cells, and nucleic acids, due to the growing trend of personalized treatments to reduce chronic disease-related mortality rates.

As major manufacturers are focusing their efforts on the release of freezers and refrigerators, cryogenic storage systems, and other equipment for the storage of biobank samples, the market is expected to place a greater emphasis on temperature control systems, boosting global demand for Biobanks. The equipment segment is being driven by an increase in the number of Biobanks in several countries, as well as a desire for sophisticated biobanking equipment.

Companies Mentioned

Report Scope:

In this report, the Global Biobanks Market has been segmented into following categories, in addition to the industry trends which have also been detailed below:

Global Biobanks Market, By Type:

Global Biobanks Market, By Sample Type

Global Biobanks Market, By Application:

Global Biobanks Market, By End-User:

Global Biobanks Market, By Region:

For more information about this report visit https://www.researchandmarkets.com/r/x26mlq

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Insights on the Biobanks Global Market to 2027 - Regenerative Medicine Applications for Biobanking Market will Drive Growth - ResearchAndMarkets.com -...

Cell-free Protein Expression Market to be Worth $475.1 Million by 2030 – Grand View Research, Inc. – Yahoo Finance

SAN FRANCISCO, Sept. 26, 2022 /PRNewswire/ -- The global cell-free protein expression market share is expected to reach USD 475.1 million by 2030, according to a new report by Grand View Research, Inc. The market is expected to expand at a CAGR of 8.48% from 2022 to 2030. Growing demand for novel biologic products for the treatment of severe chronic diseases such as, cancer, multiple sclerosis, and anemia is a major factor contributing to the market growth. For instance, as reported by the world health organization (WHO) in 2020, there were 10 million deaths or about 1 in 6 deaths due to cancer making it to be one of the major causes of death worldwide. Such rising cancer incidences are increasing the adoption of protein biologics as an alternative treatment option due to their target-specific treatment with fewer side effects compared to other treatments which is positively impacting the market growth.

Grand View Research, Inc., Logo

Funding in genomic sciences and precision medicine R&D is aiding the market growth. For instance, in May 2022, the Medical College of Wisconsin's Center for Genomic Sciences and Precision Medicine received USD 10 million funding for exploring genomic applications for the treatment of various rare and undiagnosed diseases. Moreover, investments by government initiatives are advancing and expanding the R&D activities of proteomics. For instance, in August 2020, the National Institutes of Health granted a $10.6 Million Federal Grant to the University of Arkansas for Medical Sciences to expand its proteomic resources. Similarly, in June 2022 British Columbia government invested and is managing large-scale genomics and proteomics research projects based on health, forestry, and agriculture among others. Thus, such funding initiatives are expected to boost the adoption of the proteomics and genomics in R&D and fuel the market growth during the forecast period.

Key Industry Insights & Findings from the report:

By product, the expression systems segment held the largest share of the cell-free protein expression market. E. coli lysates is one of the most preferred lysates commercially due to cost-effectiveness and higher protein yield.

The wheat germ cell-free protein expression system segment is expected to grow lucratively over the forecast period. This system is a choice of preference for numerous applications in protein research comprising options for protein labeling and the expression of proteins such as multiple protein complexes and membrane proteins.

By application, the enzyme engineering segment held a larger share of the global market. Enzyme engineering plays an important role in bio manufacturing synthetic biology, and medicine.

The transcription & translation systems segment by method captured the highest revenue share of the market in 2021. Coupled transcription and translation (TNT) systems offer investigators time-saving options for eukaryotic in vitro transcription and translation, by connecting these processes in a single tube format.

By end-user, the pharmaceutical & biotechnological companies segment held a larger share in 2021, owing to the expansion of the current manufacturing capacities coupled with increasing prevalence of chronic disease which in turn demands for novel therapeutic drugs.

North America dominated the global market in 2021 due to the growth in the biotechnology and pharmaceutical industry, presence of high research and development investment, and the development of novel cell-free protein engineering products in the region.

The Asia Pacific is expected to grow considerably in the future increasing investments by major market players coupled with funding by the government for R&D.

A few of the key market players include Thermo Fisher Scientific, Inc,Takara Bio Company, New England Biolabs, Merck KGaA and others.

Read 160-page market research report, "Cell-free Protein Expression Market Size, Share & Trends Analysis Report By Product (Expression Systems, Reagents), By Application (Enzyme Engineering, Protein Labeling), By Method, By End-use, By Region And Segment Forecasts, 2022 - 2030", published by Grand View Research.

Cell-free Protein Expression Market Growth & Trends

Moreover, the surge in infectious diseases such as lower respiratory infections and human immunodeficiency virus (HIV), among others in recent years due to climate change, changing land-use patterns, and rapid urbanization are expected to aid in the market growth. For instance, according to WHO, lower respiratory infections ranked fourth place in causing deaths globally. In addition, in 2020, according to UNAIDS there were approximately 38.4 million people across the globe with HIV. Thus, the rise in infectious diseases require effective diagnosis and treatment options such as CFPE in the market. For instance, CFPE based system can be activated in less time by adding water. This feature helps in the portable diagnosis of infectious diseases. Therefore, rising infectious diseases can increase the applications of CFPS in treatment and diagnosis, and are likely to contribute to the market growth in the near future.

The development of vaccines and treatment was an emergency requirement globally to treat and combat the spread of COVID-19 infection. The low-cost, rapid manufacture and production of therapeutic antibodies were expected in the market. The conventional method of manufacturing antibodies relied on cell-based protein expression and this production required nine months or more. The CFPE-based vaccine production cut the time from a few months to one month or a few weeks. For instance, SwiftSacle Biologics, cell-free lysate-derived E. coli bacteria shrank the timeline of vaccine production from nine months to one month and turned out to be a game changer during the pandemic. Therefore, the CFPS advantages over traditional cell-based methods increased the applications of CFPS in the industries during COVID-19 and led to a boost in the market growth.

The increase in investments by various pharmaceuticals, biopharmaceutical companies is increasing the R&D activities of genomics & proteomics in drug development. For instance, Thermo Fisher Scientific invested in a spatial proteomics Ionpath firm to scale up the MIBIscope instruments and end-to-end spatial proteomics services to meet the increasing demand for services. In addition, in Jan 2022, Protai received funding of $8 million to provide an AI-based proteomics platform. This effective approach improved the development process and accuracy of drug discovery by saving time and lowering the costs of R&D. Such R&D investments increased the adoption of proteomics and genomics and are expected to contribute to the market growth.

On the other hand, Cell-free protein expression turns costly in the up scaled experiments due to the complexity of the cell-free lysates from the eukaryotic sources and the challenges in post-translational modifications of biomolecules due to misfolding or pleiotropic interactions with cellular components. The CFPE offers low protein production that can be used in small scale production and turns expensive for large scale production in industries. For instance, as per a research article published in the Journal of visualize experiments in Feb 2019, commercial CFPS kits, such as iPE-Quick Kit (Sigma-Aldrich) cost around USD 0.82 per microgram of protein, while Expressway (Thermo Fisher) costs about USD 0.76 per microgram of protein, excluding the cost of labor and equipment. Therefore, CFPE is expensive in large scale production and can impede the market growth.

Cell-free Protein Expression Market Segmentation

Grand View Research has segmented the global cell-free protein expression market based on product, application, method, end-use, and region:

Cell-free Protein Expression Market - Product Outlook (Revenue, USD Million, 2018 - 2030)

Expression Systems

E. coli Cell-free Protein Expression System

Wheat Germ Cell-free Protein Expression System

Rabbit Reticulocytes Cell-free Protein Expression System

Insect Cells Cell-free Protein Expression System

Human Cell-free Protein Expression System

Others

Reagents

Cell-free Protein Expression Market - Application Outlook (Revenue, USD Million, 2018 - 2030)

Cell-free Protein Expression Market - Method Outlook (Revenue, USD Million, 2018 - 2030)

Cell-free Protein Expression Market - End-User Outlook (Revenue, USD Million, 2018 - 2030)

Cell-free Protein Expression Market - Regional Scope Outlook (Revenue, USD Million, 2018 - 2030)

North America

Europe

Asia Pacific

Latin America

Middle East & Africa

List of Key Players of Cell-free Protein Expression Market

Thermo Fisher Scientific, Inc.

Takara Bio Company

Merck KGaA

New England Biolabs

Promega Corporation

Jena Bioscience GmbH

GeneCopoeia, Inc.

Biotechrabbit GmbH

Cube Biotech GmbH

CellFree Sciences Co., Ltd.

Check out more related studies published by Grand View Research:

Cell Culture Protein Surface Coating Market - The global cell culture protein surface coating market size is expected to reach USD 2.5 billion by 2030, registering a CAGR of 15.2% from 2022 to 2030, according to a new report by Grand View Research, Inc. Increasing focus on stem cell research and development is the most crucial factor that drives the industry growth.

Protein Labeling Market - The global protein labeling market size is expected to reach USD 4.11 billion by 2030, according to a new report by Grand View Research, Inc. The market is expected to expand at a CAGR of 7.6% from 2022 to 2030. The study of Post-translational Modification (PTM) of proteins has gained immense popularity in cell biology and disease treatment and prevention.

Cell Line Development Market - Global cell line development market size is expected to reach USD 6.24 billion by 2022, according to a new report by Grand View Research, Inc. The Increasing demand for monoclonal antibodies and patent expiration of blockbuster biologics are expected to drive the cell line development industry over the forecast period.

Browse through Grand View Research's Biotechnology Industry Research Reports.

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Grand View Research, U.S.-based market research and consulting company, provides syndicated as well as customized research reports and consulting services. Registered in California and headquartered in San Francisco, the company comprises over 425 analysts and consultants, adding more than 1200 market research reports to its vast database each year. These reports offer in-depth analysis on 46 industries across 25 major countries worldwide. With the help of an interactive market intelligence platform, Grand View Research Helps Fortune 500 companies and renowned academic institutes understand the global and regional business environment and gauge the opportunities that lie ahead.

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Cell-free Protein Expression Market to be Worth $475.1 Million by 2030 - Grand View Research, Inc. - Yahoo Finance