Hypertension Clinical Trials Pipeline Analysis: 90+ Companies are Working to Improve the Treatment Space | DelveInsight – GlobeNewswire

New York, USA, Oct. 03, 2022 (GLOBE NEWSWIRE) -- Hypertension Clinical Trials Pipeline Analysis: 90+ Companies are Working to Improve the Treatment Space | DelveInsight

As per a statement of World Health Organization (WHO), Hypertension is one of the silent killers in 21st century and is one of the biggest global public health concerns. Factors like technological advancement, a growing aging population, and people affected by diabetes, and high blood pressure are favoring the market. Some of the key players contributing to the worldwide anti-hypertensive medication market include Quantum Genomics, Nicox, Santen Pharmaceuticals, Ionis Pharmaceuticals, United Therapeutics Corporation, and several others.

DelveInsights 'Hypertension Pipeline Insight 2022' report provides comprehensive global coverage of available, marketed, and pipeline hypertension therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the hypertension pipeline domain.

Key Takeaways from the Hypertension Pipeline Report

Request a sample and discover the recent advances in hypertension treatment drugs @Hypertension Pipeline Report

The hypertension pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage hypertension products, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the hypertension pipeline landscape.

Hypertension Overview

High blood pressure (hypertension) is a common condition in which the blood's long-term force against your artery walls is high enough to cause health problems such as heart disease. Age, smoking, drinking, overweight are among the prominent factors for causes of hypertension.

Even when blood pressure readings reach dangerously high levels, most people with high blood pressure have no hypertension symptoms. Some people with high blood pressure may experience headaches, shortness of breath, or nosebleeds. Still, these signs and hypertension symptoms aren't specific and usually don't appear until the high blood pressure has progressed to a severe or life-threatening level.

Several tests such as ECG, EKG, Echocardiogram, Ambulatory monitoring, la tests, and others are used for hypertension diagnosis.

Find out more about hypertension medications @Hypertension Treatment Drugs

A snapshot of the Hypertension Pipeline Drugs mentioned in the report:

Learn more about the emerging hypertension pipeline therapies @Hypertension Clinical Trials

Hypertension Therapeutics Assessment

Thehypertension pipelinereport proffers an integral view of the hypertension emerging novel therapies segmented by stage, product type,molecule type, mechanism of action, and route of administration.

Scope of the Hypertension Pipeline Report

Dive deep into rich insights for drugs for hypertension treatment, visit @Hypertension Treatment

Table of Contents

For further information on the hypertension pipeline therapeutics, reach out @Hypertension Drugs

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Hypertension Clinical Trials Pipeline Analysis: 90+ Companies are Working to Improve the Treatment Space | DelveInsight - GlobeNewswire

Research Shows Promise for Directing Later Lines of Therapy for Hodgkin Lymphoma – Targeted Oncology

New therapies have improved outcomes for patients in frontline treatment for Hodgkin lymphoma, and research now is addressing how subsequent therapies can meet needs of patients who progress after early lines of treatment.

When a patient has progressed through chemotherapytheyve had a stem cell transplant, theyve had brentuximab vedotin [Adcetris; Seagen] and theyve had PD-1 blockade, [physicians] are unsure of what treatments are available, Alex F. Herrera, MD, associate professor in the Division of Lymphoma, Department of Hematology and Hematopoietic Cell Transplantation at City of Hope in Duarte, California, said in an interview with The SOHO Daily News before the Tenth Annual Meeting of the Society of Hematologic Oncology (SOHO 2022).

Most patients with Hodgkin lymphoma can be cured by chemotherapy and radiotherapy, but the 20% to 25% of patients who do not respond can be as difficult to treat as those with other cancers, says Herrera. This means reducing the number of patients who relapse is crucial. Two major breakthroughs in this setting have been the introduction of brentuximab vedotin and PD-1 blockade, both of which have advanced to being used in the early lines of therapy in the United States. As the standard becomes using novel agents like brentuximab vedotin in frontline therapy, and maybe someday PD-1 blockade in frontline therapy, it even makes this a more pressing need to find therapies that work after a patient has progressed on those therapies, Herrera says.

Herreras presentation at SOHO 2022 discusses approaches to subsequent therapy for patients who have received brentuximab vedotin and PD-1 blockade. He says that although they have improved the outcomes of patients with Hodgkin lymphoma, patients who are not cured by initial therapies are now often resistant to these treatments as well. More durable responses are also needed for those who do benefit from these therapies, since it is a minority of patients who will have a long-term durable response from these immunotherapies when they are used alone.

Hodgkin lymphoma is a disease that typically affects younger patients, says Herrera. If a patient is resistant to therapy, our goal is to be able to not just get a patient in response, but [to keep] a patient in response for as long as we can.

A wide range of options could offer survival benefit to patients with relapsed disease. Because few new agents have been approved for patients with relapsed disease after brentuximab vedotin and PD-1 blockade, clinical trials play a major role in offering patients the best available care.

Emerging Therapies

New agents such as antibody-drug conjugates (ADCs) could offer a next-line approach. Whereas brentuximab vedotin targets CD30, camidanlumab tesirine (ADCT-301) is another ADC that targets CD25, which is also located on or around Hodgkin lymphoma cells. A phase 2 trial (NCT04052997) is investigating this ADC in patients who previously received brentuximab vedotin and an antiPD-1 agent.

Extending the length of benefit from antiPD-1 agents and overcoming resistance to immune checkpoint inhibitors is an important area of investigation due to the major role antiPD-1 agents now play in treating Hodgkin lymphoma. One potential approach is combining PD-1 blockade with an epigenetic-based or other targeted therapy. These include hypomethylating agents such as decitabine and azacitidine as well as histone deacetylase inhibitors such as vorinostat (Zolinza; Merck) and entinostat.

A study conducted in China (NCT03250962, NCT02961101) showed a significantly longer duration of response and favorable efficacy with the addition of decitabine to the antiPD-1 agent camrelizumab for patients with Hodgkin lymphoma who were PD-1 nave as well as those who were resistant to prior antiPD-1 therapy.1,2 Herrera is helping lead a similar study (NCT05162976) at City of Hope evaluating azacitidine plus nivolumab (Opdivo; Bristol Myers Squibb) to assess how a hypomethylating agent can improve response to immunotherapy. He is also the principal investigator of a phase 1 study (NCT03150329) of vorinostat (Zolinza; Merck) combined with pembrolizumab (Keytruda; Merck) in patients with Hodgkin lymphoma and other lymphoma types.

Herrera says targeted therapy that can extend the duration of benefit from immunotherapy would be an ideal approach in patients with low disease burden or fewer symptoms, because they are not in need of a fast-acting regimen and can benefit from the greater tolerability of immunotherapy. When a patient is resistant to immunotherapy, if we can re-sensitize them with something thats reasonably well tolerated and get them another year or two of response, [and] buy them that time, that might be a valuable option, he says.

For patients with higher disease burden who are more heavily symptomatic, chemotherapy may be the best approach to get a strong, rapid response. Research has also shown that PD-1 blockade can cause patients to become more sensitive to subsequent treatments,3 meaning chemotherapy could be used in combination with immunotherapy or afterward in patients who previously progressed on therapies such as the ABVD combination regimen (doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, and dacarbazine).

Drugs already in use such as lenalidomide (Revlimid; Bristol Myers Squibb), everolimus (Afinitor; Novartis), and temsirolimus (Torisel; Pfizer) can also have a role as subsequent therapies when patients need to achieve a strong anticancer response to improve their outcomes, according to Herrera.

Cellular Therapies

Cellular therapies such as chimeric antigen receptor (CAR) T-cell therapy have made an impact in non-Hodgkin lymphoma and other hematologic malignancies, providing long-term durable remissions in many patients who had few options remaining. Herrera says CD30-targeted CAR T-cell therapies are promising for Hodgkin lymphoma, although they are not yet approved, and several CAR T-cell trials such as the phase 2 CHARIOT study (NCT04268706) are under way. A lingering question for him is whether CAR T-cell products will lead to durable responses in the relapsed population that is resistant to chemotherapy, immunotherapy, and CD30-targeted ADCs.

Herrera says he and his colleagues look for patients who may benefit from trials of cellular therapies that evaluate CAR T cells or natural killer T cells that can result in a durable response. We are trying to refer patients [to trials] or give patients these types of cellular therapies when they are available, he said.

Although the advances in the field have deemphasized the need for patients to receive an allogeneic stem cell transplant, Herrera anticipates it may still have a role as survival is now extended for patients who now may receive 5 or more prior lines of therapy. Four or 5 years later, then you have all these patients who are now progressing on these later-line therapies and they need something else, he says. I think understanding the role allogeneic stem cell transplant may play isa bit of an unresolved question that probably is going to need to be explored again.

There is a range of options available to patients. Theres a lot of drug development happening. And I think that early results are promising and exciting, Herrera says. My talk is about just opening that door and showing folks that theres a lot out there that were studying and that is possible.

REFERENCES:

1. Nie J, Wang C, Liu Y, et al. Addition of low-dose decitabine to anti-PD-1 antibody camrelizumab in relapsed/refractory classical Hodgkin lymphoma.J Clin Oncol. 2019;37(17):1479-1489. doi:10.1200/JCO.18.02151

2. Liu Y, Wang C, Li X, et al. Improved clinical outcome in a randomized phase II study of anti-PD-1 camrelizumab plus decitabine in relapsed/refractory Hodgkin lymphoma.J Immunother Cancer. 2021;9(4):e002347. doi:10.1136/jitc-2021-00234

3. Rossi C, Gilhodes J, Maerevoet M, et al. Efficacy of chemotherapy or chemo-anti-PD-1 combination after failed anti-PD-1 therapy for relapsed and refractory Hodgkin lymphoma: a series from Lysa centers. Am J Hematol. 2018;93(8):1042-1049. doi:10.1002/ajh.25154

Original post:
Research Shows Promise for Directing Later Lines of Therapy for Hodgkin Lymphoma - Targeted Oncology

Transcenta Received IND Clearance from FDA for Its Best-In-Class MASP2 Targeting Antibody TST004 for the Treatment of IgA Nephropathy – PR Newswire

SUZHOU, China, Oct. 4, 2022 /PRNewswire/ -- Transcenta Holding Limited ("Transcenta") (HKEX: 06628), a clinical stage biopharmaceutical company with fully-integrated capabilities in discovery, research, development and manufacturing of antibody-based therapeutics, announces that TST004, its best-in-class, humanized monoclonal antibody targeting MASP2, has received IND clearance from U.S. Food and Drug Administration (FDA).

MASP2, mannose-binding protein-associated serine protease 2, is a key enzyme in the lectin pathway initiation of complement activation. Studies have shown that lectin pathway activation contributes to multiple human diseases such as immunoglobulin A nephropathy (IgAN), hematopoietic stem-cell transplantationassociated thrombotic microangiopathy (HSCT-TMA). Therefore, inhibition of MASP2 might be a potential treatment approach for diseases related to lectin pathway activation.

TST004 is a humanized mAb targeting mannose-binding protein-associated serine protease 2 (MASP2) and designed to prevent the inflammation and tissue damage mediated by lectin pathway complement activation.

In June 2022, Transcenta was selected to present the preclinical data of TST004 at the 2022 ISN Frontiers Meetings of Complement-Related Kidney Diseases in Bergamo, Italy: https://www.transcenta.com/newsDet/id-93

"There is a high unmet medical need for patients with IgA nephropathy, with around 30 to 45% of them ultimately developing end stage kidney disease and available treatment options remaining symptomatic in nature. Targeting the lectin pathway activation with our best-in-class TST004 antibody is a potentially transformative therapeutic alternative." said Dr. Caroline Germa, Transcenta's Executive Vice President, Global Medicine Development and Chief Medical Officer.

About TST004

TST004 is a humanized mAb targeting mannose-binding protein-associated serine protease 2 (MASP2) and designed to prevent the lectin pathway complement-mediated inflammation. Transcenta discovered and developed TST004 in-house and plan to develop TST004 for IgA nephropathy (IgAN), a highly prevalent chronic kidney disease with very limited treatment options. TST004 also has therapeutic potential in a number of other indications, such as thrombotic microangiopathy (TMA), representing significant market potential.

About Transcenta Holding Limited

Transcenta (HKEX: 06628) is a clinical stage biopharmaceutical company with fully integrated capabilities in antibody-based biotherapeutics discovery, research, development and manufacturing.

Transcenta has established global footprint, with Headquarters and Discovery, Clinical and Translational Research Center in Suzhou, Process and Product Development Center and Manufacturing Facility in Hangzhou, and Clinical Development Centers in Princeton, US and in Beijing, Shanghai and Guangzhou of China, and External Partnering Center in Boston and Los Angeles, US. Transcenta has also initiated the construction of the Group Headquarters and the second high-end biopharmaceutical facility with ICB as its core technology in Suzhou Industrial Park. Transcenta is developing ten therapeutic antibody molecules for oncology and selected non-oncology indications including bone and kidney disorders.

For more information, please visit http://www.transcenta.com and https://www.linkedin.com/company/transcenta.

Forward-Looking Statements

This news release may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words "anticipate", "believe", "estimate", "expect", "intend" and similar expressions, as they relate to Transcenta, are intended to identify certain of such forward-looking statements. Transcenta does not intend to update these forward-looking statements regularly.

These forward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of Transcenta with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond Transcenta's control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, Transcenta's competitive environment and political, economic, legal and social conditions.

Transcenta, the Directors and the employees of Transcenta assume (a) no obligation to correct or update the forward-looking statements contained in this site; and (b) no liability in the event that any of the forward-looking statements does not materialize or turn out to be incorrect.

SOURCE Transcenta Holding Limited

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Transcenta Received IND Clearance from FDA for Its Best-In-Class MASP2 Targeting Antibody TST004 for the Treatment of IgA Nephropathy - PR Newswire