Scientific Advisory Board strengthens LianBio’s mission of bringing novel therapeutics to Greater China and Asia Scientific Advisory Board strengthens LianBio’s mission of bringing novel therapeutics to Greater China and Asia
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LianBio Announces Formation of Scientific Advisory Board
CAMBRIDGE, Mass., April 14, 2022 (GLOBE NEWSWIRE) -- Vor Bio (Nasdaq: VOR), a clinical-stage cell and genome engineering company, today announced that Dr. Christopher Slapak, Chief Medical Officer for Vor Bio plans to retire. The Vor Bio clinical team is fully resourced and continues to actively recruit patients into VBP101, the Company’s Phase 1/2a first-in-human study of VOR33 in patients with AML who are at high risk of relapse. An executive search to replace Dr. Slapak is underway.
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Vor Bio Announces Retirement of Chief Medical Officer
SOUTH SAN FRANCISCO, Calif., April 14, 2022 (GLOBE NEWSWIRE) -- CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of conditionally activated oncology therapeutics, today announced that John A. Scarlett, M.D. is retiring from its board of directors, effective when his current term expires at the company’s next annual meeting of stockholders, which is currently scheduled to be held on June 15, 2022.
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CytomX Therapeutics Announces Retirement of John A. Scarlett, M.D. from Board of Directors
PASADENA, CA, April 14, 2022 (GLOBE NEWSWIRE) -- LIXTE Biotechnology Holdings, Inc. (Nasdaq: LIXT), a clinical-stage drug discovery company developing pharmacologically active drugs for use in cancer treatment, today announced that it has closed a registered direct offering with certain institutional and accredited investors for $5.8 million of common stock. The Company issued a total of 2,900,000 shares of common stock at a purchase price of $2.00 per share.
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LIXTE Biotechnology Announces the Closing of $5.8 Million Registered Direct Offering Priced At-The-Market
Albany NY, United States: Stem cells are found in all human beings, from the initial stages of human growth to the end of life. All stem cells are beneficial for medical research; however, each of the different kinds of stem cells has both limitations and promise. Embryonic stem cells that can be obtained from a very initial stage in human development have the prospect to develop all of the cell types in the human body. Adult stem cells are found in definite tissues in fully developed humans.
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Stem cells are basic cells of all multicellular animals having the ability to differentiate into a wide range of adult cells. Totipotency and self-renewal are characteristics of stem cells. However, totipotency is seen in very early embryonic stem cells. The adult stem cells owes multipotency and difference flexibility which can be exploited for next generation therapeutic options. Recently, scientists have also recognized stem cells in the placenta and umbilical cord blood that can give rise to several types of blood cells.
Research for stem cells is being undertaken with the expectation of achieving major medical inventions. Scientists are attempting to develop therapies that replace or rebuild spoiled cells with the tissues generated from stem cells and offer hope to people suffering from diabetes, cancer, spinal-cord injuries, cardiovascular disease, and many other disorders.
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The stem cell therapy market is segmented on the basis of type, therapeutic applications, cell source, and geography. On the basis of type, the stem cell therapy market is categorized into allogeneic stem cell therapy and autologous stem cell therapy. Allogeneic stem cell therapy includes transferring the stem cells from a healthy person (the donor) to the patients body through high-intensity radiation or chemotherapy.
Allogeneic stem cell therapy is used to treat patients who do not respond fully to treatment, who have high risk of relapse, and relapse after prior successful treatment. Autologous stem cell therapy is a type of therapy that uses the person's own stem cells. These type of cells are collected earlier and returned in future.
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The use of stem cells is done to replace damaged cells by high doses of chemotherapy, and to treat the person's underlying disease. On the basis of therapeutic applications, the stem cell therapy market is segmented into cardiovascular diseases, wounds and injuries, musculoskeletal disorders, gastrointestinal diseases, surgeries, neurodegenerative disorders, and others. On the basis of cell source, stem cells therapy is segmented into bone marrow-derived mesenchyme stem cells, adipose tissue-derived mesenchyme stem cells, and cord blood or embryonic stem cells.
By geography, the market for stem cell therapy is segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America leads the stem cell therapy market owing to rising awareness among people, early treatment adoption, and new product innovations. Europe is the second leading market for stem cell therapy due to development and expansion of more efficient and advanced technologies.
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The Asia Pacific stem cell therapy market is also anticipated to grow at an increasing rate owing to increasing healthcare spending, adoption of western lifestyles, and growth in research and development. Asia Pacific is the fastest growing region for stem cell therapy as several players have invested in the development of new stem cell technologies. These factors are expected to drive the growth of the stem cell therapy market globally during the forecast period.
The major player in the stem cell therapy market are Regenexx, Takara Bio Company, Genea Biocells, PromoCell GmbH, CellGenix GmbH, Cellular Engineering Technologies, BIOTIME, INC., Astellas Pharma US, Inc., AlloSource, RTI Surgical, Inc., NuVasive, Inc., JCR Pharmaceuticals Co., Ltd., Holostem Terapie Avanzate S.r.l., PHARMICELL Co., Ltd, ANTEROGEN.CO., LTD., The Future of Biotechnology, and Osiris Therapeutics, Inc. Rising demand for advanced stem cell therapies will increase the competition between players in the stem cell therapy market.
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Continuous Glucose Monitoring Market: Increase in incidence and prevalence rate of diabetes type 1 and type 2 across the globe is anticipated to boost the growth of the global market during the forecast period. Continuous glucose monitoring systems are real-time glucose sensing and monitoring devices that measure and display glucose levels of a patient at regular intervals.
Diabetes Management Market: The biggest driving factor for the market growth is the growing prevalence of both Type I as well as Type II diabetes. This condition coupled with considerable rise in the obese population across the globe is also helping the global diabetes management market to develop.
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Stem Cell Therapy Market: North America Leads the Market Owing to Rising Awareness among People - BioSpace
ABC24 talked with Randy Hutchinson from the Better Business Bureau of the Mid-South about a lawsuit against one company and what consumers need to watch out for.
MEMPHIS, Tenn. The Federal Trade Commission and Georgia Attorney General have sued the founders of a company they claim has made unsubstantiated claims its stem cell therapy can treat arthritis, joint pain, and other orthopedic ailments.
The company is called Stem Cell Institute of America. It claimed its treatments are comparable to or better than surgery, steroid injections, and painkillers. The FTC said the company charged up to $5,000 per injection. It said a related company taught chiropractors and other healthcare professionals how to offer stem cell therapy.
ABC24 talked with Randy Hutchinson from the Better Business Bureau of the Mid-South about the claims and what consumers need to watch out for.
They're sometimes called the body's "master cells" because they develop into blood, brain, bones, and other organs.
Stem cells from bone marrow or blood are used to treat certain kinds of cancer and disorders of the blood and immune system. But other uses have not been properly studied and approved.
The FDA cites these potential risks from unproven treatments:
There could be safety risks even using a persons own stem cells.
The FTC has also looked into companies claiming their stem cell therapies can treat Parkinson's, multiple sclerosis, COVID, and a host of other ailments. They're sometimes referred to as "regenerative medicine."
Take miracle health care claims with a grain of salt.
Check out a company and treatment online using terms like "complaints," "scam" and "reviews."
Consult your own health care provider before using any product or treatment.
Stem cell transplants can effectively cure a wide range of diseases, from blood cancers to rare genetic disorders. They've been used for decades and are considered standard treatment for certain conditions.
But for a good number of patients, stem cell transplants are out of reach. Drug regimens used to prepare the body for a transplant are toxic and can cause serious side effects. The transplanted cells don't always "engraft," or take root in the bone marrow. Even when they do, patients' disease may linger or recur.
A biotech startup launching Wednesday with $50 million in funding hopes that, by combining cell, antibody and gene editing technologies, at least some of these problems can be overcome. Called Cimeio Therapeutics, the new company is led by a team of pharmaceutical industry veterans and an advisory board filled with scientific luminaries, including immunologist Jeffrey Bluestone and gene editing pioneer Fyodor Urnov.
Cimeio's approach involves "shielding" transplanted cells by genetically editing them in ways that allows paired immunotherapies to be safely used both before and after a transplant.
Thomas Fuchs
Courtesy of Cimeio Therapeutics
"We think that this can really unleash the power of hematopoietic stem cell transplant and make a lot more patients eligible for it," said Thomas Fuchs, Cimeio's CEO and a former Genentech executive.
The "shielding" technology used by Cimeio was developed in Switzerland at the laboratory of Lukas Jeker, a physician-scientist from Basel University Hospital who will join Cimeio as head of gene editing.
Jeker's lab discovered that protein receptors on the surface of cells could be genetically edited in such a way that prevented antibodies from binding to them, while leaving their function intact. In preclinical testing, these edits could cloak, or "shield," the cells from being depleted by antibody drugs and T cell therapies.
The work could have powerful implications for improving stem cell transplant and adoptive cell therapy, according to Fuchs.
Once a stem cell or T cell is shielded, a complementary immunotherapy could be used to either help ready patients for a transplant or to further treat disease afterwards, he said. "Maybe you could give a cycle or two of the paired immunotherapy, implant the shielded cells and then continue to administer the immunotherapy," he added.
If the shielding works as intended, Cimeio could develop treatments for conditioning that are more tolerable than the chemotherapy or radiation-based regimens currently in use. Shielding might also allow existing drugs that target cell proteins on healthy as well as diseased cells to be used more flexibly with transplants, such as to treat residual disease that lingers afterwards.
For example, Cimeio could engineer stem cells that are protected against binding via a protein called CD19 that's often the target for CAR-T therapies that treat lymphoma, but is also found on healthy B cells that help the immune system fight off threats.
"One benefit could be that you could prevent a lifetime of B cell depletion, which happens when you give a CAR-T," said Fuchs.
Alex Mayweg
Courtesy of Cimeio Therapeutics
Cimeio was built from Jeker's lab by Versant Ventures at the company's "Ridgeline" incubator in Basel, which has previously produced companies like Monte Rosa Therapeutics and Black Diamond Therapeutics. The initial $50 million Versant provided will fund Cimeio through next year, said Alex Mayweg, a managing director at the venture firm and a Cimeio board member. Additional investors will be brought on later this year or early next, Mayweg said.
Cimeio will need the money, as its research and development plans are expansive. The company has identified four drug candidates already and envisions a dozen more behind those, said Fuchs. Its research spans blood cancers, rare genetic diseases and autoimmune disorders.
In some cases, Cimeio will develop paired immunotherapies to go with the shielded cells. In others, it will use existing treatments. Three of the first four candidates involve protecting hematopoietic stem cells, while the fourth involves T cells. The company hopes to begin human testing next year.
Cimeio plans to choose gene editing technologies based on the type of alteration it needs to make to shield cells. "Rather than building up an internal editing capability," Mayweg said, "we wanted to stay as flexible as possible."
That might mean partnerships or alliances with other companies, some of which have reached out to Cimeio already, according to Mayweg.
Cimeio is aided by a group of scientific advisers notable for their work in areas the company is focusing on. Urnov, of the University of California, Berkeley, is well known for his research in gene editing using zinc finger nucleases and CRISPR. Bluestone previously led the Parker Institute for Cancer Immunotherapy and is CEO of the cell therapy-focused biotech Sonoma Biotherapeutics.
Suneet Agarwal, a co-program leader of the stem cell transplant center at Boston Children's Cancer and Blood Disorders Center, is also on the advisory board, while Cimeio has a research collaboration in place with Matthew Porteus, a gene editing specialist at Stanford University.
About 20 people currently work at Cimeio directly, a number Fuchs expects will grow as the company's research advances. Another 15 are currently supporting Cimeio from Versant's Ridgeline group.
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Versant-backed startup launches with plans to broaden cell therapy's reach - BioPharma Dive
Elsy Boglioli, former Chief Operating Officer at French cell therapy biotech Cellectis, founder and Chief Executive Officer of biotechnology consulting practice Bio-Up, joins as Chair of the Board
Melissa Carpenter, PhD, Chief Scientific Officer of US-based cell & gene therapy biotech ElevateBios Regenerative Medicine unit, joins as independent board member.
Bordeaux, France / April 14th, 2022 TreeFrog Therapeutics, a biotechnology company aimed at making safer, more efficient and more affordable cell therapies based on induced pluripotent stem cells (iPSCs), today announced the appointment of new independent members to its board: Elsy Boglioli, former Chief Operating Officer at Cellectis, Founder and Chief Executive Officer of healthtech consulting practice Bio-Up, and Melissa Carpenter, PhD, Chief Scientific Officer of the Regenerative Medicine business unit at ElevateBio, a technology-driven company focused on powering transformative cell and gene therapies. Elsy Boglioli will be the Chair of the Board.
Following our Series B, we welcomed new investors to our board: Bpifrance Large Venture, Leonard Green & Partners, and Bristol Myers Squibb. I am delighted to reinforce our organization with our new independent board members to guide our strategy and serve our ambition. Elsy, with her profound knowledge of the biotech industry, will chair our board, bringing a new dynamic to our governance and scale-up efforts. Melissa, a world-renowned expert in iPSCderived cell therapies, will reinforce our U.S. network and help us steer our programs toward clinical trials. Also, I would like to warmly thank our co-founder, Jean-Luc Treillou, for his work as a Chairman over the first years of the company. Frdric Desdouits, PhD, Chief Executive Officer, TreeFrog Therapeutics.
I am thrilled to join TreeFrog as the company advances its unique platform and enters its next phase of growth. Together, we aim to solve major challenges facing the development of cell therapies and craft transformative, scalable, high quality treatments that can benefit large patient pools. Melissa Carpenter, PhD, Chief Scientific Officer, ElevateBio, Regenerative Medicine
Elsy Boglioli, Founder and Chief Executive Officer, Bio-Up
Elsy Boglioli started her career in 2006 at the Boston Consulting Group, where she served as partner and managing director, leading the biotech business in Europe. In 2017, she joined the French cell therapy biotech company Cellectis as Executive Vice-President Strategy and Business Development and Chief Operating Officer, before founding the independent consulting practice Bio-Up. As part of her activities within Bio-Up, she was appointed to the boards of Gensight Biologics, OSE Immunotherapeutics, Metafora Biosystems, Inova, Kelindi and Womed. Graduate from the Ecole Polytechnique engineering school in Paris, France, Elsy Boglioli holds a masters degree in Economy and Management from the Pompeu Fabra University, Barcelona, Spain, and was trained in immuno-oncology at the Gustave Roussy Institute of Oncology, Paris, France.
Melissa Carpenter, PhD, Chief Scientific Officer, ElevateBio, Regenerative Medicine
Author of over 50 peer-reviewed articles and inventor of 34 issued patents, Melissa Carpenter has been pioneering the field of stem cell-derived cell therapies for the past 25 years. She started her career at CytoTherapeutics (became StemCells, Inc), where she derived human neural stem cells and successfully developed the media formulation used for scale-up of these cells. Carpenter then joined Californian cell therapy biotech Geron in 1998, as Director of Stem Cell Biology, managing research and preclinical programsin regenerative medicine, before taking an academic position as Principal Investigator at the Robarts Research Institute in Canada. In 2004, she joined Novocell (now Viacyte Inc.) as Vice-President of Research and Development, advancing a novel cell therapy program in diabetes, based on encapsulated human pluripotent stem cells. She then established her own consulting practice - Carpenter Group Consulting -, providing strategic, scientific and manufacturing guidance for the development of over 75 cell and gene therapies. In 2019, she was appointed Chief Scientific Officer of the Regenerative Medicine business unit of ElevateBio, a technology-driven company with integrated technology platforms, including gene editing, induced pluripotent stem cells (iPSCs) and protein, vector and cellular engineering, focused on the discovery, development and manufacturing of transformative cell and gene therapies. Initially trained in psychology, Melissa Carpenter completed a PhD in the Laboratory of Cellular and Molecular Neurobiology of the University of California, Irvine, in 1989.
About TreeFrog Therapeutics
TreeFrog Therapeutics is a French-based biotech company aiming to unlock access to cell therapies for millions of patients. TreeFrog Therapeutics is developing a pipeline of therapeutic candidates using proprietary C-StemTM technology, allowing for the mass production of induced pluripotent stem cells and their differentiation into ready-to-transplant microtissues with unprecedented scalability and cell quality. Bringing together over 80 biophysicists, cell biologists and bioproduction engineers, TreeFrog Therapeutics raised $82M over the past 3 years to advance its pipeline of stem cell-based therapies in the field of neurodegeneration, cardio-metabolic disorders, and immuno-oncology. The company is currently opening technological hubs in Boston, USA, and Kobe, Japan, to drive the adoption of C-StemTM and initiate co-development partnerships with leading academic, biotech and industry players in the field of cell therapy. http://www.treefrog.fr
Media Contact
Pierre-Emmanuel Gaultier
TreeFrog Therapeutics
+ 33 6 45 77 42 58
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TREEFROG THERAPEUTICS EXPANDS BOARD WITH NEW INDEPENDENT MEMBERS FROM THE CELL THERAPY INDUSTRY - BioSpace
DUBLIN--(BUSINESS WIRE)--The "Dry Eye Products Market Forecast to 2028- COVID-19 Impact and Global Analysis - by Product; Type" report has been added to ResearchAndMarkets.com's offering.
The dry eye products market is projected to reach US$ 9,681.73 million by 2028 from US$ 6,837.26 million in 2021; it is estimated to grow at a CAGR of 5.1% from 2021 to 2028.
Factors such as rising incidences of dry eye and growing geriatric population are drive the growth of the market. However, the side effects caused due to eye drops hamper the market growth.
The Asia Pacific region is a highly affected region in the world as the outbreak of COVID-19 has come from China. Countries such as China, India, and South Korea have registered the highest number of COVID-19 positive patients. The countries have imposed lockdowns for several months.
Few countries such as South Korea and China have recovered from the pandemic. However, India is still struggling to fight against COVID-19. Therefore, there has been a great economic drop in the country, which is trying to recover. The fast recovery from the situation was seen due to the shift of focus of various companies operating in the ophthalmic division.
Companies have shifted their focus towards supplying reliefs to these countries as corporate social responsibility (CSR) activity. Also, governments are seeking help from the private sectors to contribute during the tough situation. Therefore, market players have strengthened their efforts to supply personal protective equipment.
For instance, in January 2020, Allergan plc has donated US$ 9,514 million (one million yen) to the Chinese Red Cross Foundation to provide medical masks, robes, gloves, eyewear, and other protective equipment for medical providers in Wuhan.
The incidence of dry eye is commonly seen in older people of age 65 and above. The number of geriatric population is increasing rapidly across the world. The older population is becoming a significant social transformation such as depending on the other for financial needs and wellness on the younger people in the present century.
Older people are significantly contributing to the development of the medical sector as it is helps by offering various innovative techniques to treat older people. Various healthcare companies design their products by focusing on geriatric population. As the degeneration process among older people is much faster, they are highly prevalent to dry eye conditions.
Therefore, the high prevalence of dry eye among older population is likely to promote manufacturers to introduce new dry eye products in the market, which, in turn, contributes to the growth of the market. For instance, according to the Department of Economic and Social Affairs, the United Nations report for 2019, there were 703 million individuals of age 65 years and above and is estimated to grow double to 1.5 billion by 2050.
Product Insights
The dry eye products market is segmented on the basis of product and type. Based on the product, the market is segmented into artificial tears, antibiotic drops, hormone drops, and others. The artificial tears segment held the largest share of the market in 2021, and the hormone drops segment is estimated to register the highest CAGR of 5.9% in the market during the forecast period.
World Health Organization, Royal Society of Medicine, Brazilian Research Association for Vision and Ophthalmology, Canadian Dry Eye Summit, International Dacryology Society, National Health Service, Royal Society of Medicine are among the primary and secondary sources referred to while preparing the report on the dry eye products market.
Key Market Dynamics
Market Driver
Market Restraints
Market Opportunities
Future Trends
Company Profiles
For more information about this report visit https://www.researchandmarkets.com/r/osg3y6
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Global Dry Eye Products Markets Report 2022-2028: Ongoing Research and Growing Pipeline & Opportunities in Stem Cell Therapy -...