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The Stem Cell Transplant Process – UChicago Medicine

At the University of Chicago Medicine, our transplant team works side-by-side with the patient, family and referring physician before, during and after transplantation to ensure the best possible outcome. The transplant process differs from patient to patient, but generally includes:

Most patients undergoing stem cell transplantation are cared for in our dedicated unit for approximately one week before and two to three weeks after the procedure. Select patients may receive outpatient stem cell transplant care in specially designed treatment rooms within the unit. The same physicians and nurses who provide inpatient care provide outpatient care.

The stem cell transplant unit is located on the top floor of the Center for Care and Discovery and features state-of-the-art technology and thoughtful amenities:

Our stem cell transplant physicians are members of the nationally renowned UChicago Medicine Comprehensive Cancer Center,one of only two National Cancer Institute (NCI)-designated Comprehensive Cancer Centers in Chicago. It is through the Cancer Center that we participate in clinical trials of emerging therapies. In addition, we are active participants in the Alliance for Clinical Trials in Oncology and the Blood and Marrow Transplant Clinical Trials Network. Involvement in these vital research organizations gives our patients access to the most novel and exciting treatments available.

Our stem cell transplant program laboratory is specially equipped to handle all of the blood and stem cell preparation necessary for transplant, including apheresis (separation and collection of stem cells from the blood) and cryopreservation (freezing of stem cells for future use).

Leading-edge technologies in the laboratory enable us to perform complex procedures that help improve transplant outcomes. These procedures include purging of cancerous cells and purifying donor stem cells to minimize graft-versus-host disease (a serious side effect related to the use of donor cells for transplant).

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The Stem Cell Transplant Process - UChicago Medicine

Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic …

Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to their capacity for local engrafting and differentiating into multiple tissue types. However, recent studies have revealed that implanted cells do not survive for long, and that the benefits of MSC therapy could be due to the vast array of bioactive factors they produce, which play an important role in the regulation of key biologic processes. Secretome derivatives, such as conditioned media or exosomes, may present considerable advantages over cells for manufacturing, storage, handling, product shelf life and their potential as a ready-to-go biologic product. Nevertheless, regulatory requirements for manufacturing and quality control will be necessary to establish the safety and efficacy profile of these products. Among MSCs, human uterine cervical stem cells (hUCESCs) may be a good candidate for obtaining secretome-derived products. hUCESCs are obtained by Pap cervical smear, which is a less invasive and painful method than those used for obtaining other MSCs (for example, from bone marrow or adipose tissue). Moreover, due to easy isolation and a high proliferative rate, it is possible to obtain large amounts of hUCESCs or secretome-derived products for research and clinical use.

Keywords: adipose-derived stem cells; bone marrow mesenchymal stem cells; conditioned media; exosomes; hUCESCs; mesenchymal stem cells; uterine cervical stem cells.

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Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic ...

Stem Cell Transplant the only curative treatment for Sickle cell Disease – NewsPatrolling

World Sickle Cell Day 2022:

Bangalore, June 16, 2022: There are as many as 2.5 million carrier of the gene (Hemoglobin AS) in India that can lead to sickle cell disease, with more than 1,25,000 actual patients spread across the country, with a much higher incidence in the tribal belt of the country. Sickle cell disease is associated with a significant risk of morbidity and premature mortality, especially among children. While in the west, a child receiving comprehensive care in high-resource settings has an estimated 99% survival into adulthood. However, in India, according to an ICMR study, about 20 per cent of children with sickle disease died by the age of two, and 30 per cent children with Sickle Cell Disease die before they reach adulthood.

Dr. Biju George, Professor & Head, Department of Haematology at CMC Vellore, People with Sickle Cell Disease, may beat a risk of progressive organ damage, impaired quality of life, considerable morbidity in childhood, and risk of premature mortality in adulthood [median survival of 58 years]. Sickle Cell disease patients who are undergoing regular life-long blood transfusions, have the best chance of survival and cure with a blood stem cell transplant. This transplant can come from a sibling or a family member. However, there is only a 30% chance of finding a matched sibling donor in the same family. The remaining 70% patients look for a matching donor through a stem cell registry or donor center- a database of voluntary donors between the age group of 18 to 50 years.

Dr. Govind Eriat Nair, Consultant Hematology Hemato-Oncology and Bone Marrow Transplant Gleneagles Global BGS Hospital, Bengaluru, If there is a fully HLA matched donor in the family, there is a 90-95% chance of cure with higher cure rates in younger children of below 12 years of age. However, due to underrepresentation of Indians in the global donor data pool, patients are unable to find a match on time. Also, the awareness about the disease is less, need of the hour is to raise the social awareness about this disease. Genetic counseling and newborn screening are the way forward. Effects of endogamy, consanguinity and role prenatal counseling needs to be addressed in primary screening.

DKMS BMST Foundation India is a non-profit organization dedicated to the fight against blood cancer and other blood disorders, such as thalassemia and sickle cell disease. The organization aims to give every blood disorder patient in need a second chance at life.

To mark World Sickle Cell Day, Patrick Paul, CEO, DKMS BMST Foundation India said, Sickle cell has variance and only the severe form needs a stem cell transplant. An early transplant can help patient with severe Sickle cell disease from organ damage. With rising cases in India, it is the need of the hour that stem cell transplants are made available to more patients to save lives. But due to the misconceptions and lack of awareness about blood stem cell donation, Indians are highly underrepresented in the global donor pool. This situation can only be changed by recruiting many more potential blood stem cell donors from the Indian ethnicity.

The success of a stem cell transplant depends of donors HLA (Human Leukocyte Antigen) matching the patient. The bodys immune system has proteins known as HLA to distinguish cells that belong to the body from those that do not. DKMS-BMST helps in unrelated donor transplant process which includes enrolling and counselling the donors, get their HLA typing done, facilitate search of the donors and later facilitate the blood stem cell collection and the transplant. So, far DKMS-BMST has registered over 60,000 potential donors and have helped 60 patients with second chance at life.

Register as a potential blood stem cell donor:

Healthy individuals between 18-50 years of age can register at: dkms-bmst.org/register

All it takes is five minutes of your time and a simple 3 step process:

Step 1: Visit the site, fill up an online form and you will receive a DIY swab kit at home.

Step 2: Once you receive the swab kit, fill out the consent form and take a tissue sample from the inside of your cheeks with 3 cotton swabs provided in the kit.

Step 3: Send back your swab sample in the pre-paid envelope provided.

DKMS laboratory will then analyze your tissue type and your details will be available in the global search for blood stem cell donors. If you do come up as a suitable donor, DKMS-BMST will get in touch with you straight away. Once you come up as a match, blood stem cells will be obtained from the bloodstream using a procedure called Peripheral Blood Stem Cell Collection, which is similar to a blood donation wherein only your stem cells are taken. This is a safe, non-surgical outpatient procedure.

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Stem Cell Transplant the only curative treatment for Sickle cell Disease - NewsPatrolling

Asymmetrex’s Kinetic Stem Cell (KSC) Counting Technology Is Featured in the Parent’s Guide to Cord Blood Foundation June Newsletter – 69News WFMZ-TV

The Parent's Guide to Cord Blood Foundation's monthly newsletter reports on research and development of medical treatments using blood and tissues from human umbilical cords in language that is accessible to parents of children receiving or considering such treatments. The June 14 issue of the newsletter features a graphical presentation of stem cell biotechnology company Asymmetrex's KSC technology, which can provide, for the first time, the dosage of the therapeutic stem cells in umbilical cord blood and tissues.

BOSTON, June 15, 2022 /PRNewswire-PRWeb/ -- The Parent's Guide to Cord Blood Foundation is well known for its excellence in advocacy and education to support parents negotiating medical treatments for their children that involve umbilical cord blood and tissues. The Parent's Guide monthly newsletter has a goal of presenting new advances in umbilical cord medical research and treatments in terms that are accessible by parents and others who are not experts. The June 2022 issue, published June 14, provides a graphical presentation of stem cell biotechnology company Asymmetrex's technology that provides the dose of therapeutic umbilical cord stem cells for the first time.

Determining the dosage of therapeutic tissue stem cells is a long-standing unmet need for all tissue stem cell therapies. More commonly mis-called "adult stem cells," tissue stem cells include stem cells found in adults, children, and birth tissues like the placenta and the umbilical cord. Donor umbilical cords are currently a major focus for sourcing therapeutic tissue stem cells, which are found in both their blood (hematopoietic stem cells) and their walls (mesenchymal stem cells). Whereas the medical potential of cord mesenchymal stem cells is still under investigation, the medical efficacy of cord blood hematopoietic stem cells is well established for use in the treatment of childhood leukemias.

Cord blood treatments for children have a continuing need for a method to determine the dose of the therapeutic stem cells. The Parent's Guide newsletter feature describes the two industry standards for certifying cord blood units, flow cytometry and the colony-forming unit (CFU) test. Although they are currently industry certification requirements, neither of these methods gives the stem cell dose or tells which cord blood units will be effective. By some reports, this deficiency leaves nearly 20% of treated children at risk for death.

This June's article is the Parent's Guide newsletter's second feature on Asymmetrex's tissue stem cell counting technology. The first feature appeared in the January 2019 issue of the newsletter. It related the historical context, envisioned applications, and potential impact of kinetic stem cell (KSC) counting, but did not delve into how the technology worked. The latest feature uses a graphical slide format to illustrate how Asymmetrex applies computational simulation to conventional cell count data to determine the number of tissue stem cells in a sample. Asymmetrex's President and CEO James L. Sherley, M.D., Ph.D. is confident that the newsletter's presentation "will help both non-experts and experts to understand how Asymmetrex counts therapeutic tissue stem cells."

In the intervening 3 years, the company's KSC counting technology has advanced greatly. Just in the previous week, at the Meeting in the Millyard Summit of the Advanced Regenerative Manufacturing Institute, the company announced rapid-counting algorithms that will make stem cell counting sufficiently efficient to be performed routinely for research and medicine. CEO Sherley says that he is looking forward to a future Parent's Guide newsletter reporting the use of KSC counting to identify cord blood units that work all of the time for children, instead of only about 80% of the time as now.

About Asymmetrex

Asymmetrex, LLC is a Massachusetts life sciences company with a focus on developing technologies to advance stem cell medicine. The company's U.S. and U.K. patent portfolio contains biotechnologies that solve the two main technical problems stem cell-specific quantification and stem cell expansion that have stood in the way of more-effective use of human adult tissue stem cells for regenerative medicine and drug development. Asymmetrex markets kinetic stem cell (KSC) counting, the first technology for determination of the dose and quality of tissue stem cell preparations for use in stem cell transplantation medicine and pre-clinical drug evaluations. Asymmetrex is a member company of the Advanced Regenerative Manufacturing Institute | BioFabUSA (ARMI) and the Massachusetts Biotechnology Council (MassBio).

Media Contact

James L. Sherley, M.D., Ph.D., Asymmetrex LLC, 617-990-6819, jsherley@asymmetrex.com

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Asymmetrex's Kinetic Stem Cell (KSC) Counting Technology Is Featured in the Parent's Guide to Cord Blood Foundation June Newsletter - 69News WFMZ-TV

VITASPRING BIOMEDICAL CO. LTD. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS. (form 10-Q) – Marketscreener.com

Management's Discussion and Analysis of Financial Condition and Results of Operations

Caution Regarding Forward-Looking Information

This Quarterly Report on Form 10-Q, including, without limitation, statements containing the words "believes", "anticipates", "expects" and words of similar import, constitute forward-looking statements. Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements of the Company, or industry results, to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements.

Such factors include, among others, the following: international, national and local general economic and market conditions: demographic changes; the ability of the Company to sustain, manage or forecast its growth; the ability of the Company to successfully make and integrate acquisitions; existing government regulations and changes in, or the failure to comply with, government regulations; adverse publicity; competition; fluctuations and difficulty in forecasting operating results; changes in business strategy or development plans; business disruptions; the ability to attract and retain qualified personnel; and other factors referenced in this and previous filings.

Given these uncertainties, readers of this Form 10-Q and investors are cautioned not to place undue reliance on such forward-looking statements. The Company disclaims any obligation to update any such factors or to publicly announce the result of any revisions to any of the forward-looking statements contained herein to reflect future events or developments.

VitaSpring Biomedical Co. Ltd., formerly Shemn Corp., was incorporated in Nevada on September 6, 2016. We are a start-up business company. We have been engaged in the business of developing and marketing products that promote wellness and a healthy lifestyle since 2019. A change of 100% of Company's ownership occurred effectively on January 21, 2020. As a result, we changed Company name from Shemn Corp. to VitaSpring Biomedical Co. Ltd. on February 17, 2020.

VitaSpring Biomedical Co., Ltd aims to build a cell medical industry, invest in research and development of stem cell applications in regenerative medicine, establish advanced medical research centers and high standard cell production centers, and provide "GTP" standard stem cell preparations for the development of cellular drugs.

For future business development and medical applications, VitaSpring cooperates with affiliated companies to support the mass production and commercialization of X.msc-related medical projects. Some X.msc-based projects are researches and trials of Investment New Drugs and part of them are related to X.exosome, the critical material in the related skincare products. VitaSpring management also expect X.msc-related medical projects to implement in hospitals from a small scale in the future five years.

On March 30, 2020, VitaSpring filed a Certificate of Amendment to its Articles of Incorporation (the "Articles of Amendment") with the Secretary of State of the State of Nevada effecting a name change of the Company to VitaSpring Biomedical Co. Ltd. (the "Corporate Action"). The Corporate Action and the Amended Articles became effective on April 21, 2020, following compliance with notification requirements of the Financial Industry Regulatory Authority.

Under new management, VitaSpring has completed the transition from patent technology into the know-how in the mass-production process of the purifying and culturing technology in the allogeneic mesenchymal stem cell production from the maternal-part placenta. The subject know-how can effectively and steadily culture more than 20 generations of sub-culture cells, which maintain the same level of activity index and contain the magnification of one thousand exosomes than other MSCs in terms of per ml. Accordingly, VitaSpring is able to build stem cell bank regulated by US FDA to provide the ready-to-use allogeneic mesenchymal stem cell for the emergent allogeneic stem cell transplantation at the cost the patient can afford.

VitaSpring's research team has been awarded the 16th, 17 th, 18 th Taiwan National Innovation Award certificates in 2019, 2020, and 2021 and joined the regenerative medicine flagships of the Ministry of Science and Technology from 2007 to 2020, including research projects for the mechanism of human placenta mesenchymal stem cells in different diseases. It highlights the technological foundation for the future clinical application of X.msc.

Through the development of cell medicine, we became a leading international business group in the fields of regenerative medicine applied to the innovative fields of medicine, preventive health care, beauty, and anti-aging. We do not sell products in a form for use by consumers although we may, in the future, develop products for use by consumers.

We have many unique advantages elevating us to be the best in the industry:

1. Discovery and successful isolation of special mesenchymal stem cells (X.msc)

2. Unlike typical MSCs, X.msc do not promote cancer and tumor growth, and is safe to use for the entire body

3. Homogeneous purification technology

4. Viability of X.msc is 1000 time that of the competitor

5. Able to proliferate and maintain stemness of stem cells to 25+ generations

6. Exclusive composition formula of culture medium

7. The exclusive formula of exosomes have a variety of applications

8. Extensive uses of X.msc

9. Immunomodulation and anti-inflammation effect

We file with the SEC our annual reports on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K and amendments to reports to be filed pursuant to Sections 13(a) and 15(d) of the Securities Exchange Act of 1934, as amended. The public may read and copy any materials we file with the SEC at the SEC's Public Reference Room at 100 F Street, NE, Washington, D.C. 20549, on official business days during the hours of 10 a.m. to 3 p.m. The public may obtain information on the operation of the Public Reference Room by calling the SEC at 1-800-SEC-0330. The SEC maintains a website at http://www.sec.gov that contains reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC.

Our corporate headquarters are located at 400 Spectrum Center Dr. #1620, Irvine, CA 92618. Our telephone number is (949) 202-9235. We maintain a website at http://www.vitaspringbio.com that links to our electronic SEC filings and contains information about our subsidiaries which is not a part of this report. All the above documents are available free of charge on our website as soon as reasonably practicable after filing such material electronically or otherwise furnishing it to the SEC

Results of Operations for the Three months Ended April 30, 2022 Compared to the Three months ended April 30, 2021

Revenue and cost of goods sold

For the Three months ended April 30, 2022 and April 30, 2021 the Company generated total revenue of $1,490,000 and $533,800 from selling products to the customer. The cost of goods sold for the quarter ended April 30, 2022 and April 30, 2021 was $922,000 and $294,000, which represent the cost of raw materials.

Total operating expenses for the quarter ended April 30, 2022 and April 30, 2021 were $224,873 and $60,390. The increase was primarily related to increased selling, general and administrative expenses.

The net income for the quarter ended April 30, 2022 and April 30, 2021 was $276,656 and $235,662, accordingly.

Liquidity and Capital Resources and Cash Requirements

At April 30, 2022, the Company had cash of $79,151. The Company had working capital of $1,823,019.

During the quarter ended April 30, 2022, the Company generated $(28,061) of cash in operating activities.

During the quarter ended April 30, 2022 the Company used no cash in investing activities or financing activities.

We cannot guarantee that we will manage to sell all the shares required. We will attempt to raise the necessary funds to proceed with all phases of our plan of operation. As of the date of this report, the current funds available to the Company will not be sufficient to continue maintaining a reporting status.

Our auditors have issued a "going concern" opinion, meaning that there is substantial doubt we can continue as an on-going business for the next twelve months unless we obtain additional capital. Our only sources for cash at this time are investments by others in this offering, selling our paper dung products and loans from our director. We must raise cash to implement our plan and stay in business.

Management believes that current trends toward lower capital investment in start-up companies pose the most significant challenge to the Company's success over the next year and in future years. Additionally, the Company will have to meet all the financial disclosure and reporting requirements associated with being a publicly reporting company. The Company's management will have to spend additional time on policies and procedures to make sure it is compliant with various regulatory requirements, especially that of Section 404 of the Sarbanes-Oxley Act of 2002. This additional corporate governance time required of management could limit the amount of time management has to implement is business plan and impede the speed of its operations.

Limited operating history; need for additional capital

There is no historical financial information about us upon which to base an evaluation of our performance. We are in a start-up stage of operations and have generated limited revenues since inception. We cannot guarantee that we will be successful in our business operations. Our business is subject to risks inherent in the establishment of a new business enterprise, including limited capital resources and possible cost overruns due to price and cost increases in services and products.

Off-Balance Sheet Arrangements

We do not maintain any off-balance sheet arrangements, transactions, obligations or other relationships with unconsolidated entities that would be expected to have a material current or future effect upon our financial condition or results of operations.

The Company has a retained earnings of $1,093,380 and a negative cash flow from operations amounting to $(28,061) for the three months ended April 30, 2022. The Company had $1,490,000 in revenues for the three months ended April 30, 2022. The Company currently earned profit for the period and is in the process of completing its efforts to establish a stabilized source of revenue sufficient to cover operating costs over an extended period. Therefore, there is still a substantial doubt about the Company's ability to continue as a going concern. Management anticipates that the Company will be dependent, for the near future, on additional investment capital to fund operating expenses. The Company intends to position itself so that it will be able to raise additional funds through the capital markets. In light of management's efforts, there are no assurances that the Company will be successful in this or any of its endeavors or become financially viable and continue as a going concern.

Recent Accounting Pronouncements

In October 2016, the FASB issued ASU 2016-16, Income Taxes (Topic 740): Intra-Entity Transfer of Assets Other than Inventory, which requires the recognition of the income tax consequences of an intra-entity transfer of an asset, other than inventory, when the transfer occurs. ASU 2016-16 is effective for interim and annual periods beginning after December 15, 2018, with early adoption permitted. .

In February 2016, the FASB issued ASU 2016-02, Leases, which will amend current lease accounting to require lessees to recognize (i) a lease liability, which is a lessee's obligation to make lease payments arising from a lease, measured on a discounted basis, and (ii) a right-of-use asset, which is an asset that represents the lessee's right to use, or control the use of, a specified asset for the lease term. ASU 2016-02 does not significantly change lease accounting requirements applicable to lessors; however, certain changes were made to align, where necessary, lessor accounting with the lessee accounting model. This standard will be effective for fiscal years beginning after December 15, 2018, including interim periods within those fiscal years.

Management has considered all recent accounting pronouncements issued since and their potential effect on our financial statements. The Company's management believes that these recent pronouncements will not have a material effect on the Company's consolidated financial statements.

Other recent accounting pronouncements issued by the FASB, including its Emerging Issues Task Force, the American Institute of Certified Public Accountants, and the Securities and Exchange Commission did not or are not believed by management to have a material impact on the Company's present or future financial statements.

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VITASPRING BIOMEDICAL CO. LTD. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS. (form 10-Q) - Marketscreener.com

Maike Sander named to lead the Max Delbrck Center – EurekAlert

image:Maike Sander has been selected to direct the Max Delbrck Center for Molecular Medicine (MDC). view more

Credit: Peter Himsel / MDC

On November 1, 2022, Prof. Maike Sander will take the reins as Scientific Director and Chair of the Board of the Max Delbrck Center for Molecular Medicine in the Helmholtz Association (MDC). The Supervisory Board of the MDC formally appointed her to the post on Thursday, June 16, 2022. The MDC, which is celebrating its 30th anniversary this year, is one of five Health Centers in the Helmholtz Association of German Research Centers. The internationally renowned researcher and experienced science manager Maike Sander will be succeeding Prof. Thomas Sommer, who has directed the MDC on an interim basis since 2019. That will make Sander the first woman to head one of the Helmholtz Health Centers.

The MDC has distinguished itself as an internationally renowned center for highly innovative biomedical research, says Maike Sander. Work at the MDC lays the foundation for better medicine of the future. The MDC provides on outstanding environment for research and attracts talent from around the globe. I had the opportunity to experience this first-hand as a visiting professor at the MDC. As Scientific Director, my goal will be to further strengthen the MDCs role as a leading biomedical research center and to deepen partnerships with other institutions in Berlin and beyond, so that our discoveries can be rapidly turned into medical innovations. Sander emphasizes that medical innovation needs strong basic science, clinical science and industry partners components that are all part of the vibrant Berlin biomedical ecosystem, she points out. The Berlin region is developing into a flourishing biotech pharma hub and I see the MDC as a principal driver of innovation in this landscape. I very much look forward to working with all stakeholders across Berlin.

Maike Sanders research focuses on identifying novel therapeutic approaches for diabetes. To this end, Sander studies the molecular mechanisms that underlie the formation and function of the different cell types in the pancreas, in particular the insulin-producing beta cells. Her goal is to identify strategies for replacing beta cells in diabetes using beta cells derived from human pluripotent stem cells.

Since 2012, Sander has served as the Director of the Pediatric Diabetes Research Center at the University of California, San Diego (UC San Diego), where she is also a Professor in the Departments of Pediatrics and Cellular & Molecular Medicine. In Berlin, Maike Sander will be appointed as Professor at the Charit Universittsmedizin.

Maike Sander is an outstanding scientist with a track record of innovation in biomedical research, says Bettina Stark-Watzinger, Germanys Federal Minister of Education and Research. I am delighted we have been able to bring her back to Germany after many years in the United States and to win her as the new Scientific Director of the Max Delbrck Center. It demonstrates the attractiveness of Berlin as a hub for biomedical research. As a scientist and administrator, Prof. Sander is the perfect match for the MDC with its mission to improve human health through transformative biomedical research. Also, having a female leader is an important signal. Prof. Sanders appointment represents a significant gain for German research.

Berlins Senator for Higher Education and Research, Health, Long-Term Care and Gender Equality, Ulrike Gote, says: In Prof. Maike Sander, the Max Delbrck Center has gained an internationally renowned scientist as its new Scientific Director. I warmly welcome her to the science and healthcare metropolis Berlin. Prof. Sanders expertise and experience provide the ideal background for future development of the MDC and for increasing the international visibility of the vibrant life sciences community at the MDC and in Berlin. As the senator in charge of higher education, research, and gender equality, I am delighted to see a woman at the helm of a Helmholtz Health Center.

I got to know Maike Sander as an expert in diabetes and stem cells when she was a visiting professor at the MDC, says OtmarD.Wiestler, President of the Helmholtz Association. With her high scientific standing and international experience, she is the ideal person to determine the future direction of the MDC as Scientific Director and Chair of the Board. With Prof. Sander we are gaining an excellent scientist whose expertise will be of tremendous benefit to the Helmholtz Association. A critical focus area is the development of precision medicine approaches. The MDC is at the forefront of advancing research in this important area. I look forward to working with Prof. Sander and to a vivid exchange of ideas.

Maike Sander, a native of Gttingen, is 54 years old. After graduating with a medical degree from the University of Heidelberg Medical School in 1994, she conducted research at the University of California, San Francisco. Before moving to UC San Diego in 2008, she held faculty positions at Hamburg Medical School and the University of California, Irvine. An expert on insulin-producing pancreatic beta cells, she has nearly 30 years of experience in medicine and diabetes research.

Sander is an elected member of the German National Academy of Sciences Leopoldina, the Association of American Physicians, and the American Society of Clinical Investigation. In addition, she is a member of two NIH consortia: The Human Islet Research Network and the NIH Impact of Genomic Variation on Function Consortium, which seeks to define basic mechanisms of gene regulation.

She is a recipient of the Grodsky Award of the Juvenile Diabetes Research Foundation, the 2022 Albert Renold Prize of the European Association for the Study of Diabetes, and the Alexander von Humboldt Foundation Research Award. Since 2019, Sander has been an Einstein Visiting Fellow at the Berlin Institute of Health at Charit (BIH).

30 Years MDC

Sander Laboratory and Publications at University of California, San Diego

German Federal Ministry of Education and Research (BMBF) Division for Press; Social Media; Internet Kapelle-Ufer 1 10117 Berlin +49-(0)30-1857-5050 presse@bmbf.bund.de

Jutta Kramm Head of the Staff Unit Communications Max Delbrck Center for Molecular Medicine in the Helmholtz Association (MDC) +49-(0)30-9406-2140 jutta.kramm@mdc-berlin.de or presse@mdc-berlin.de

The Max Delbrck Center for Molecular Medicine in the Helmholtz Association (MDC) is one of the worlds leading biomedical research institutions. Max Delbrck, a Berlin native, was a Nobel laureate and one of the founders of molecular biology. At the MDCs locations in Berlin-Buch and Mitte, researchers from some 60 countries analyze the human system investigating the biological foundations of life from its most elementary building blocks to systems-wide mechanisms. By understanding what regulates or disrupts the dynamic equilibrium in a cell, an organ, or the entire body, we can prevent diseases, diagnose them earlier, and stop their progression with tailored therapies. Patients should benefit as soon as possible from basic research discoveries. The MDC therefore supports spin-off creation and participates in collaborative networks. It works in close partnership with Charit Universittsmedizin Berlin in the jointly run Experimental and Clinical Research Center (ECRC), the Berlin Institute of Health (BIH) at Charit, and the German Center for Cardiovascular Research (DZHK). Founded in 1992, the MDC today employs 1,600 people and is funded 90 percent by the German federal government and 10 percent by the State of Berlin.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Maike Sander named to lead the Max Delbrck Center - EurekAlert

Orthopedic Regenerative Medicine Market To Witness the Highest Growth Globally in Coming Years 2022-2028: Ortho Regenerative Technologies Inc,…

TheGlobal Orthopedic Regenerative MedicineMarket 2022 by Manufacturers, Regions, Type and Application, Forecast to 2028 is a valuable source of insightful data for business strategists. It provides the industry overview with growth analysis and historical & futuristic cost, revenue, demand and supply data (as applicable). The research analysts deliver an elaborate description of the value chain, future roadmaps and its distributor analysis. This Market study offers comprehensive data that enhances the understanding, scope, and application of this report. Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche Orthopedic Regenerative Medicine are aligned with your aims.

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Top LeadingCompanies/Players: Ortho Regenerative Technologies Inc, Personalized stem cells Inc., Anika Therapeutics Inc., Arthrex Inc., Baxter International Inc., Conmed Corporation, Aziyo Biologics, Curasan Inc., Swiss biomed Orthopedics AG, Octane Medical Inc., Stryker Corporation, Carmell Therapeutics Corporation, Zimmer Holdings, Smith & Nephew plc., NuVasive Inc., and Other.

This report segments the Global Orthopedic Regenerative Medicine Market on the basis of Types are:

Stem Cell Therapy (Allogeneic Bones, Autogeneic Bones, and Bone Grafting)

Plasma Based Therapy

Tissue Engineering (Allograft)

On the basis of Application, the Global Orthopedic Regenerative Medicine Market is segmented into

Osteoarticular Diseases

Rheumatoid Arthritis

Ligament Injuries

Bursitis

Osteoporosis

Region Included are:North America, Europe, Asia Pacific, Oceania, South America, Middle East & Africa

Country Level Break-Up:United States, Canada, Mexico, Brazil, Argentina, Colombia, Chile, South Africa, Nigeria, Tunisia, Morocco, Germany, United Kingdom (UK), the Netherlands, Spain, Italy, Belgium, Austria, Turkey, Russia, France, Poland, Israel, United Arab Emirates, Qatar, Saudi Arabia, China, Japan, Taiwan, South Korea, Singapore, India, Australia and New Zealand etc.

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The content of the study subjects, includes a total of 15 chapters:

Chapter 1, to describe Orthopedic Regenerative Medicine product scope, market overview, market opportunities, market driving force and market risks.

Chapter 2, to profile the top manufacturers of Orthopedic Regenerative Medicine, with price, sales, revenue and global market share of Orthopedic Regenerative Medicine from 2019 to 2022.

Chapter 3, the Orthopedic Regenerative MedicineOrthopedic Regenerative Medicine competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast.

Chapter 4, the Orthopedic Regenerative Medicine breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2017 to 2028.

Chapter 5 and 6, to segment the sales by Type and application, with sales market share and growth rate by type, application, from 2017 to 2028.

Chapter 7, 8, 9, 10 and 11, to break the sales data at the country level, with sales, revenue and market share for key countries in the world, from 2017 to 2022.and Orthopedic Regenerative Medicine market forecast, by regions, type and application, with sales and revenue, from 2022 to 2028.

Chapter 12, the key raw materials and key suppliers, and industry chain of Orthopedic Regenerative Medicine.

Chapter 13, 14, and 15, to describe Orthopedic Regenerative Medicine sales channel, distributors, customers, research findings and conclusion, appendix and data source.

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https://www.reporthive.com/Report/3157280/orthopedic-regenerative-medicine-market

The report delivers an in-depth evaluation of the Orthopedic Regenerative Medicine market by highlighting data on different aspects which contains drivers, restraints, opportunities, and threats. This information can help stakeholders to make appropriate decisions before investing. Additional, it also allows you to do valuable competitor research to get inspiration for marketing the products. When it comes to satisfaction, it is necessary to get definitive idea about what is exactly going in the market. This report exactly provides overall market scenario.

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Orthopedic Regenerative Medicine Market To Witness the Highest Growth Globally in Coming Years 2022-2028: Ortho Regenerative Technologies Inc,...

Stem Cell Therapy Global Market Report 2022: Allogeneic Stem Cell Therapy; Autologous Stem Cell Therapy – ResearchAndMarkets.com – Business Wire

DUBLIN--(BUSINESS WIRE)--The "Stem Cell Therapy Global Market Report 2022: By Type, By Cell, By Application, By End-User" report has been added to ResearchAndMarkets.com's offering.

The global stem cell therapy market is expected to grow from $10.67 billion in 2021 to $11.99 billion in 2022 at a compound annual growth rate (CAGR) of 12.4%. The market is expected to reach $21.17 billion in 2026 at a CAGR of 15.3%.

The stem cell therapy market consists of the sales of stem cell therapy and related services by entities (organizations, sole traders, and partnerships) that provide stem cell therapy. Stem cell therapy, also known as regenerative medicine, promotes the repair response of diseased patient, dysfunctional or injured tissue using stem cells or their derivatives. Only goods and services traded between entities or sold to end consumers are included.

The main types of stem cell therapy are allogeneic stem cell therapy and autologous stem cell therapy. Allogeneic stem cell transplantation involves transferring stem cells from a healthy person (the donor) to the patient's body after high-intensity chemotherapy or radiation,. The various sources of cell include adult stem cells; induced pluripotent stem cells and embryonic stem cells that are used for the treatment of musculoskeletal disorders; wounds and injuries; cancer; autoimmune disorders and others. The therapies are used by hospitals and clinics.

North America was the largest region in the stem cell therapy market in 2021. Middle East is expected to be the largest growing region in the forecast period. The regions covered in this report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The rising prevalence of chronic diseases contributed to the growth of the stem cell therapy market. Long working hours, limited physical activity, and unhealthy eating and drinking habits contribute to the prevalence of chronic diseases among people, thus driving the need for stem cell therapy. According to a United Nations article, by 2030, the proportion of global deaths due to chronic diseases is expected to increase to 70% of total deaths. The global burden of chronic diseases is expected to reach about 60%. The rising prevalence of chronic diseases is expected to drive the stem cell therapy market.

The high cost of stem cell therapy is expected to limit the growth of the stem cell therapy market. The pressure to contain costs and demonstrate value is widespread. Political uncertainty and persistent economic stress in numerous countries are calling into question the sustainability of public health care funding.

In less wealthy countries, the lack of cost-effective therapies for chronic diseases has impacted the health conditions of the population and has led to a low average life expectancy. According to the DVCSTEM, the average cost of stem cell therapy in the USA is between $20,000 to $25,000, in Mexico, it is $33,000, in Central America, it is $30,000, and in Asia, it is $50,000, thus restraining the growth of the market.

The companies in the stem cell therapy market are increasingly investing in strategic partnerships. The strategic partnership is a mutually beneficial agreement between two companies that do not compete directly with each other.

Major players in the stem cell therapy market are

Key Topics Covered:

1. Executive Summary

2. Stem Cell Therapy Market Characteristics

3. Stem Cell Therapy Market Trends And Strategies

4. Impact Of COVID-19 On Stem Cell Therapy

5. Stem Cell Therapy Market Size And Growth

5.1. Global Stem Cell Therapy Historic Market, 2016-2021, $ Billion

5.1.1. Drivers Of The Market

5.1.2. Restraints On The Market

5.2. Global Stem Cell Therapy Forecast Market, 2021-2026F, 2031F, $ Billion

5.2.1. Drivers Of The Market

5.2.2. Restraints On the Market

6. Stem Cell Therapy Market Segmentation

6.1. Global Stem Cell Therapy Market, Segmentation By Type, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

6.2. Global Stem Cell Therapy Market, Segmentation By Cell Source, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

6.3. Global Stem Cell Therapy Market, Segmentation By Application, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

6.4. Global Stem Cell Therapy Market, Segmentation By End-User, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

7. Stem Cell Therapy Market Regional And Country Analysis

7.1. Global Stem Cell Therapy Market, Split By Region, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

7.2. Global Stem Cell Therapy Market, Split By Country, Historic and Forecast, 2016-2021, 2021-2026F, 2031F, $ Billion

For more information about this report visit https://www.researchandmarkets.com/r/15018b

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Stem Cell Therapy Global Market Report 2022: Allogeneic Stem Cell Therapy; Autologous Stem Cell Therapy - ResearchAndMarkets.com - Business Wire

Study explores the promising but still puzzling field of stem cell therapy for painful joint injuries – University of Calgary

An interdisciplinary group of researchers from across the University of Calgary campus has received two years of funding from the New Frontiers in Research Fund (NFRF) to explore novel stem cell therapies to treat challenging joint injuries that can lead to chronic pain in horses and humans.

Joint injuries involving both soft tissue and cartilage damageare common in both equine and human athletes, and poor healing can lead to chronic joint pain. Researchers are studying how stem cell therapy may help with healing.

Our equine athletes are no different (than humans), and this opportunity to put our minds together to investigate treating these challenging injuries is really exciting for both veterinary and human medicine, says Dr. Holly Sparks, DVM, PhD'19, assistant professor of large animal surgery in the Faculty of Veterinary Medicine (UCVM) and Canada Research Chair (Tier II) in Equine Regenerative Medicine.

Dr. Holly Sparks, DVM, PhD'19 a large-animal surgeon and regenerative medicine researcher is involved in a collaborative project investigating stem cell-based approaches to treating joint injuries in veterinary and human medicine.

Rahil Tarique

Were looking at utilizing regenerative-medicine approaches to treat these injuries early, in a way that will hopefully encourage more functional healing in the short term and reduce joint pain in the long term, says Sparks.

While there is a lot of promise for stem cell therapies, and no shortage of pre-clinical studies around the world, not one stem-cell therapy for humans or animals has yet been approved for use in North America.

There has been a disproportionately large amount of work done in this area, but we're no closer to an answer because there's so much variability in how people conduct this research, says Dr. Roman Krawetz, PhD, an associate professor specializing in stem cells and tissue engineering at the Cumming School of Medicine (CSM), member of the McCaig Institute for Bone and Joint Health at the CSM, and Canada Research Chair (Tier II) in Bone and Joint Stem Cell Biology.

The collaborative research team also includes Dr. Brent Edwards, PhD, associate professor in the Faculty of Kinesiology, who researches biomechanics and musculoskeletal injuries; Dr. Mike Scott, DVM, associate professor at UCVM and surgeon at Moore Equine in Calgary; and Dr. Arindom Sen, BSc'91, MSc'98, PhD'03, a professor in the Schulich School of Engineering who studies how to scale up production of stem cells. This interdisciplinary team approach is really the key to this work, and the chance to work together on this is a really exciting opportunity, says Sparks.

Dr. Roman Krawetz, PhD, an associate professor in stem cells and tissue engineering, says, while theres been a large amount of work done in stem cell therapy research, were no closer to an answer.

Supplied by Roman Krawetz

The researchers will apply the highest possible standards in consistently producing and applying stem cells for the specific application to the stifle joint, or the equine equivalent of the human knee. As well as strict quality control on how stem cells are grown, collected and manipulated, the team has the clinical knowledge to assess the outcomes.

Did this have any benefit? And if so, where? Did it regrow cartilage? Did it reduce inflammation? Did it reduce pain? says Krawetz. Whatever answer we get is going to be important to the field. If we can show that it's beneficial, great. If we show that it's not beneficial, I think that that's equally important.

The research will not only help guide veterinarians and horse-owners managing these types of injuries, but will also add significantly to the emerging body of knowledge around stem cells. While cell-based therapy shows considerable promise for treating musculoskeletal injuries like those studied here, there's still a lot to be learned about how stem cell therapy may work, says Sparks. Hopefully, we can shed some light on that with this project.

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Study explores the promising but still puzzling field of stem cell therapy for painful joint injuries - University of Calgary

How stem cell therapy can help with Alzheimers disease – Times of India

We all love to reminisce about the good old days! Memories are part of our life and everyone reflects upon the good and bad times spent. Unfortunately, with a steadily increasing incidence of Alzheimers disease globally, many are losing their memoriesin fact even losing the ability to remember basic activities that do not as such require conscious thought. What is Alzheimers disease? Alzheimers disease (AD) is one of the major causes of dementia, and as of the last decade, there are approximately 3.7 million Indians with the condition. The lack of awareness regarding the early symptoms of the disease and knowledge about the associated risks poses challenges in early diagnosis and prompt interventions. Moreover, one cannot prevent or reverse the disease process. AD begins in individuals around the age of 40-50 years when certain unwanted proteins accumulate in the brain. These protein deposits interfere with the connections in the brain and disrupt the transmission of informationconsider them roadblocks that cannot be crossed. Thus, with time and depending on the extent of protein accumulation, a patient begins to forget things and gradually fails to form a link between the sensory information gained and the required action. For example, in advanced stages, apart from being unable to recognise people (including family members) a patient might not know what to do with a toothbrush or how the lock on a door should be fastened, although these are things he/she would have been doing for years together. It is a sad sight to watch a family member deteriorate in this manner. Since such episodes affect the overall quality of life of the patient, caregivers also tend to face the burden. How can this be treated? Unfortunately, there are no medications to treat the disease. Thus, the least we can do is try to slow down the progression of the condition. To begin with, annual health check-ups must be advised to everyone over the age of 45 years, adding brain imaging where required. By this we might be able to identify AD early and initiate activities and treatment that can slow the progression, says Dr Pradeep Mahajan, Regenerative Medicine Researcher. We have stem cells and growth factors in our body, which function to control inflammation, enhance the functions of other cells, and provide a constant pool of healthy cells to regenerate lost tissues. Through cell-based therapy, we are only providing these molecules at the required location in the appropriate quantity, explains Dr Mahajan. He continues, There are several other molecules, for example, chaperones (helper proteins) and exosomes (cell-associated packets of genetic material, proteins, immune cells, etc.) that act as messenger molecules, and also help in de-tangling nerve fibres and protein deposits in the brain. These can be utilised to create a healthier environment in the brain and restore internal balance (homeostasis). With more targeted therapies being researched, it might be possible to reverse AD in the future. For now, though, regenerative medicine can be a beacon of hope for patients to help lead an independent life for as long as possible in a natural, minimally invasive manner, concludes Dr Mahajan.

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How stem cell therapy can help with Alzheimers disease - Times of India