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Stem Cell Technology Helps Identify a Potential Casual Mechanism in Schizophrenia That Could Be Targeted – Brain & Behavior Research Foundation |

New research by a team that included four BBRF grantees has demonstrated the value of studying the causes of complex psychiatric illness by analyzing neurons grown in the laboratory, using stem-cell technology.

In experiments reported in Nature Communications, 2014 BBRF Young Investigator Ian Maze, Ph.D., a Howard Hughes Medical Institute Investigator at the Icahn School of Medicine at Mount Sinai, and 2019 BBRF Young Investigator Lorna A. Farrelly, Ph.D., also at Mount Sinai, and colleagues, used stem cell technology to identify a protein involved in the regulation of gene expression whose inhibition may help to ameliorate abnormalities in neurons that are associated with early pathology in schizophrenia. Adding to the interest of the finding, there is a known drug that can inhibit the protein in question, suggesting a potential future approach to treat or even prevent schizophrenia in some instances.

Developed in the second decade of the 2000s by researchers including BBRF Scientific Council members Ronald McKay, Ph.D., Stewart Anderson, M.D., Fred Gage, Ph.D. and Kristen Brennand, Ph.D., "human induced pluripotent stem cell" (hiPSC) technology involves harmlessly sampling cells (usually skin cells) from an individual and then genetically reprograming these cells to re-develop as other cell types. When reprogrammed as neural cells, these baby cells are grown in culture dishes, and can be brought together with other developing neurons to form "organoids," in which neurons and other cells found in the living brain wire together and form functional networks.

Not only does stem-cell technology enable researchers to generate virtually limitless quantities of live human neurons, overcoming the problem of having to rely on postmortem brain tissue to study brain tissue from psychiatric patients. Just as important, every cell perfectly represents the complex genetics of the patient whose donated skin cells are the basis of the organoid.

This makes hiPSC technology uniquely valuable in the study of illnesses like schizophrenia, in which genetic factors are strongly involved in causation, and pathology in many cases is hypothesized to have its origins in the early development of the braina phase that organoids can recapitulate in the lab.

The team, which included BBRF Scientific Council members Dr. Brennand (who is 2018 BBRF Maltz Prize winner, 2016 Independent Investigator and 2012 Young Investigator) and 2011 BBRF Lieber Prize winner and 2010 and 1998 BBRF Distinguished Investigator Carol A. Tamminga, M.D., induced skin cells sampled from individuals with schizophrenia to re-develop as neurons of the type found in the forebrain. Cells in the forebrain process information from the senses and are involved in thinking, perceiving, producing, and understanding language, as well as controlling motor function.

The team made an important observation in reprogrammed neurons derived from patient samples as these cells were maturing: they detected aberrant patterns of epigenetic activity. Epigenetics refers to molecular processes that affect the way specific genes are expressed in a cell. Every human cell contains an individual's entire genome, and gene-regulating factors, including epigenetic factors, determine when and where in the body or in an organ like the brain specific genes will be activated or repressed, depending upon the biological context.

The abnormal epigenetic pattern the team found is called hyperacetylation. Acetyl molecules are among the epigenetic factors that attach to DNA packaging proteins to encourage or repress gene activation. Hyperacetylation means that there are too many acetyl molecules attaching to bundles of DNA called histones. This causes one or more genes to be abnormally regulated.

The team also identified a specific protein, called BRD4, which, when blocked or repressed in its activity of "reading" the epigenetic state of a given histone, can restore or alleviate the severity of aberrant gene expression caused by hyperacetylation. Experiments indicated that a BRD4 inhibitor might specifically alleviate a kind of aberrant gene expression linked with schizophrenia.

This is exciting because a drug called JQ1 has been shown, in other research, to prevent interactions between proteins like BRD4 and bundled DNA. The drug has been tested in anti-cancer applications, but as the team notes, "the potential of using such inhibitors [of BRD4 and related proteins] to alleviate schizophrenia-related gene expression has remained unexplored."

The team proposes that treatments with JQ1 might "partially rescue" irregularities in gene expression associated with schizophrenia. They say their results warrant further experimental investigation of this possibility.

In addition to Drs. Brennand and Maze, Haitao Li, Ph.D. of Tsinghua University, PRC, was also a senior member of the team.

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Stem Cell Technology Helps Identify a Potential Casual Mechanism in Schizophrenia That Could Be Targeted - Brain & Behavior Research Foundation |

Aspen Neuroscience Announces $147.5 Million Series B Financing, Led by GV, LYFE Capital and Revelation Partners – PR Newswire

Aspen Neuroscience is preparing to study its first autologous cell replacement candidate in Parkinson's disease

GV, LYFE Capital and Revelation Partners co-led the investment round with participation from additional new investors Newton Investment Management, Singapore-based global investor EDBI, LifeForce Capital, Medical Excellence Capital Partners, Mirae Asset Capital, NS Investment and others. As part of the financing, Doug Fisher of Revelation Partners will join the board of directors.

The raise included significant investments from Series A/Seed investment teams including OrbiMed, ARCH Venture Partners, Frazier Life Sciences, Section32 and Alexandria Venture Investments.

"As the leader in autologous cell therapy development, Aspen Neuroscience is preparing to study its first cell replacement candidate in Parkinson's disease," said Damien McDevitt, Ph.D., president and chief executive officer. "This company was founded by a visionary team of scientists and patient advocates, who envisioned a day when personalized cell replacement could be used to target neurodegenerative diseases. We are happy to be aligned with such a prestigious group of founders and investors, having raised more than $220 million since the company's founding, towards our mission to develop transformational medicines for patients with limited treatment options."

The Series B funding will support the planned studies of the company'slead product candidate for Parkinson's disease, ANPD001, including its patient Screening Cohort study and the upcoming Phase 1/2a clinical trial,post-IND submission to FDA.

"This is an important milestone in the field of cell therapy for neurodegenerative diseases and we are immensely proud of this innovative team, who are working to transform the field and to modify the course of Parkinson's disease," said Faheem Hasnain, Aspen Neuroscience chairman.

Aspen is the leading company developing a personalized cell replacement using a patient's own cells, eliminating the need for immunosuppressive therapy. Developed from a simple skin biopsy, each patient's stem cell-derived dopamine neurons will be evaluated for potential effectiveness using proprietary AI-based genomics tools, before being transplanted for clinical use. Aspen Neuroscience's process allows for a reduction in the time and cost of the manufacturing process required to produce a safe, reproducible, and personalized autologous cell therapy. To date, Aspen has performed in vitro and in vivo studies demonstrating that the protocol reliably produces dopamine-releasing neurons when examined both physiologically and functionally.

Dr. McDevitt, continued, "We combine stem cell biology with innovative AI/bioinformatic and manufacturing tools to develop patient-specific approaches. To that end, the Series B financing will also support our R&D pipeline, which includes autologous gene-corrected cells and programs that explore the treatment of other neurological diseases."

About Parkinson's DiseaseParkinson's Disease is the second most common neurodegenerative disease, affecting around one million Americans and greater than ten million people worldwide, with 60,000 people newly diagnosed every year. Even with the current standard of care therapy, patients eventually develop debilitating motor complications due to loss of dopamine neurons in the brain; approximately 50% are lost even before diagnosis. Cell replacement therapy of dopamine neurons has the potential to release dopamine and reconstruct neural networks.

About Aspen NeuroscienceHeadquartered in San Diego, Aspen Neuroscience, Inc. is a development stage, private biotechnology company focused on personalized (autologous) cell therapies. The company is developing induced-pluripotent stem cells (iPSCs) to address diseases with high unmet medical need, beginning with autologous neuron replacement for both sporadic and genetic forms of Parkinson's disease (PD) and extending across the brain and affected organs.

A leading iPSC platform company, Aspen combines stem cell biology with the latest artificial intelligence and genomic approaches to investigate patient-specific, restorative treatments. The company has developed a best-in-class platform to create and characterize pluripotent-derived cell medicines, which includes in-house bioinformatics, manufacturing and QC. For more information and important updates,please visit http://www.aspenneuroscience.com.

SOURCE Aspen Neuroscience , Inc.

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Aspen Neuroscience Announces $147.5 Million Series B Financing, Led by GV, LYFE Capital and Revelation Partners - PR Newswire

INFOBAE.COM: Houston doctors and researchers that are making the biggest international impact according to the KOLs list – Most of them are women – PR…

SANTA BARBARA, Calif., May 11, 2022 /PRNewswire/ --The work of Houston doctors and researchers is getting international attention. The most researched areas in Houston after COVID are Oncology, Cardiology, and Endocrinology.

According to the KOLs list, the leading institutions are The University Of Texas MD Anderson, Houston Methodist, Harris Health System, Heart Institute, and Baylor College Of Medicine.

Gender diversity among the top Houston researchers

Ana Gannon, Director of technology of the firm Key Opinion Leaders, commented on the issue "It is not common to see the level of gender diversity we see in Houston in terms of researchers that are creating international impact with their work and findings."

"To give an example, within the group of Houston researchers working on next-generation cancer therapies, such as CAR-T, and whose work is having an international projection, the vast majority of them are women," Mrs. Gannon added.

The analysis prepared by the firm Key Opinion Leaders and available at keyopinionleaders.comquantifies the level of impact of researchers around the world for specific medical concepts like medical conditions, medications, active ingredients, treatments, devices, and more.

What is a "Key Opinion Leader"?

A key opinion leader (KOL) is an expert, thought leader, or influencer who has earned the trust of their peers for an area of knowledge. In healthcare, KOLs play an essential role in shaping the discourse around key issues and helping to drive change within the health system. Patients, physicians, and sometimes even regulatory agencies accept their input while making decisions.

Top Houston Researchers working on next-generation Cancer therapies

According to the KOLs list, some of the Houston researchers whose work on next-generation cancer therapies is getting the most international attention are:

... Please click here to see the other research categories and the full KOLs list on infobae.com.

Amy Mcquade [emailprotected] https://www.youtube.com/watch?v=t32izA3MWrwHow-to-guide for finding KOLs

SOURCE Key Opinion Leaders, LLC

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INFOBAE.COM: Houston doctors and researchers that are making the biggest international impact according to the KOLs list - Most of them are women - PR...

Cannabis, heart disease, and a soy-derived supplement that may help – Medical News Today

Researchers are still learning about the health impacts of cannabis. Derivatives of cannabis may have many health benefits. However, researchers are still learning how to balance these positives with potential health risks.

A recent study published in the journal Cell examined the adverse cardiovascular effects of cannabis and found a particular impact on cardiovascular health.

However, the researchers also found that the compound genistein may help decrease these harmful effects.

Cannabis use is becoming increasingly popular, especially for recreational purposes. But researchers are still seeking to discover the full medicinal benefits of cannabis.

The U.S. Centers for Disease Control and Prevention notes that tetrahydrocannabinol (THC) is the compound in cannabis that produces mind alterations and impaired mental functioning. Specifically, the main compound that causes these effects is delta-9-tetrahydrocannabinol (delta-9-THC). In contrast, the cannabidiol (CBD) compound of cannabis doesnt cause this sort of impairment.

Currently, the U.S. Food and Drug Administration (FDA) has approved the use of Epidiolex, which contains CBD. People can use this drug as a seizure treatment. The FDA has also approved the use of two medications with synthetic THC: Marinol and Syndros. Both of these medications can control nausea and stimulate appetite.

However, in addition to the benefits, cannabis has also been linked to health risks. One particular area of interest is the potential association between cannabis and cardiovascular problems.

When asked to comment, Paul Armentano, deputy director for the National Organization for the Reform of Marijuana Laws (NORML), noted that many studies have yielded inconsistent results regarding the impact of cannabis on cardiovascular health. He explained to Medical News Today:

Population-based studies evaluating the potential link between cannabis exposure and cardiovascular risks have, historically, yielded notoriously inconsistent resultsNonetheless, because of the lack of consistent data, NORML has long urged caution with respect to cannabis exposure among those with a history of heart disease or other cardiovascular issues, among other potentially higher-risk populations.

Therefore, more research is needed in this area.

The study in question sought to explore this link. Researchers first examined the association between cannabis use and heart attacks using the U.K. Biobank, the largest prospective cohort study to date, containing genetic and phenotypic data on 500,000 individuals ages 40-69.

Based on the evaluation of this data, cannabis use was associated with a higher risk for heart attack.

The researchers also recruited participants who smoked cannabis recreationally. They found that these participants had higher levels of inflammatory cytokines after smoking a cannabis cigarette, indicating a greater risk for atherosclerosis.

Next, the study authors examined the impact of delta-9-THC on endothelial cells, which are the cells that make up the cardiovascular system. They found that delta-9-THC caused oxidative stress and inflammation, both of which cause harm to the cardiovascular system.

In mice models, they also discovered that delta-9-THC caused vascular dysfunction. Their research indicates that delta-9-THC could damage the cardiovascular system.

To counteract these effects, the researchers tested the compound genistein derived from soybeans. They found that it helped reduce the impact of inflammation and oxidative stress on the cardiovascular system.

They further discovered that genistein helped lessen the severity of atherosclerosis in mouse models.

Dr. Joseph Wu, professor of cardiovascular medicine and of radiology, and the director of the Stanford Cardiovascular Institute, gave the studys highlights to MNT:

Our study shows that marijuana (cannabis) is linked to cardiovascular disease based on the U.K. biobank, stem cell-derived vascular cells, and mouse models. Using machine learning, we also discover a naturally occurring soybean derivative, genistein, that we can be used to block the bad effects of marijuana on the cardiovascular system. Dr. Joseph Wu

The study had several limitations. Firstly, the researchers could not show a causal relationship between cannabis use and heart attacks. They acknowledge the potential for flaws in the data from the U.K. Biobank cohort.

The study also used mice models, so caution must be exercised when applying any results to people.

Armentano also said that the study may fall short in terms of consistency of research in the area.

This latest paper is simply the latest in a long line of inconsistent results results that likely vary based on how well investigators do or do not control for potential confounding variables and behaviors among subjects.

However, he pointed out that the researchers theory, based on results from their mice studies, was that it could be due to cannabinoids triggering inflammation of the blood vessels and thus atherosclerosis is inconsistent with human observational studies.

Nevertheless, the results indicated that genistein could help mitigate the potentially harmful effects of cannabis while maintaining some of its beneficial effects.

Study authors wrote that [g]enistein, a soybean isoflavone, blocks harmful cardiovascular effects of [delta-9-THC] while reserving clinically useful effects such as sedation and analgesia.

Study author Joseph Wu further elaborated to MNT about the direction of further research in this area:

While we have shown that genistein can block the adverse effects of marijuana on the cardiovascular system using preclinical models, we need to do a randomized clinical trial to test its safety and effectiveness in humans.

Genistein might also be a new lead compound that will lead to the development of new drugs that can treat cardiovascular disease, Wu added.

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Cannabis, heart disease, and a soy-derived supplement that may help - Medical News Today

Stem Cells Market by Type (Umbilical Cord Blood Stem Cell, Embryonic Stem Cell, Adult Stem Cell, Other), Application (Diseases Therapy, Healthcare),…

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Dhirtek Business Research and Consulting most recent study on the stem cells market provides a comprehensive view of the entire market. The research report delves deeply into the global stem cells markets drivers and restraints. Analysts have extensively researched the global stem cells markets milestones and the current trends that are expected to determine its future. Primary and secondary research methods were used to create an in-depth report on the topic. Analysts have provided clients with unbiased perspectives on the global stem cells industry to assist them in making well-informed business decisions.

The comprehensive research study employs Porters five forces analysis and SWOT analysis to provide readers with a clear picture of the global stem cells markets expected direction. The SWOT analysis focuses on defining the global stem cells markets strengths, weaknesses, opportunities, and threats, whereas Porters five forces analysis emphasizes competitive competition. The research report goes into great detail about the trends and consumer behavior patterns expected to shape the global stem cells markets evolution.

Request a Sample of this Report at: https://www.dhirtekbusinessresearch.com/market-report/Stem-Cells-Market/request-for-sample-report

The global stem cells market research studys type, application, and region components are divided into three parts. Each segmentation is divided into chapters that go over the various details. The chapters include graphs that show year-over-year growth and segment-specific drivers and constraints. Furthermore, the study provides government forecasts for regional markets that affect the global stem cells sector.

Stem Cells Market Segments

Regions Covered in the Global Stem Cells Market:

In the report on the stem cells market, a detailed chapter on company profiles is included. The leading players in the global stem cells market are examined in this chapter. It contains a synopsis of the companys strategic goals and a description of its primary goods and services. An overall analysis of the organizations strategic initiatives reveals the trends that they are expected to pursue and their R&D statuses and financial outlooks. This research aims to provide readers with a thorough understanding of the global stem cells markets anticipated trajectory.

The following Companies as the Key Players in the Global Stem Cells Market Research Report:

Beikebiotech, Boyalife, CCBC, Vcanbio

Dhirtek Business Research and Consulting conducted this study using primary and secondary sources. As primary sources, industry experts from core and adjacent industries and those involved in the market. All primary sources were interviewed to obtain and verify critical qualitative and quantitative data and gain access to prospects. Secondary sources include directories, white papers, blogs, and databases.

The market size for stem cells was estimated and validated using a top-down approach. Secondary research was conducted to identify key players in the industrial value chain, and primary and secondary research was conducted to determine these companies market revenues. This includes analyzing yearly business and financial reports from major industry players and conducting in-depth interviews with CEOs, directors, vice presidents, and marketing executives.

Secondary sources were used to gather geographic market estimates, which were then cross-checked with primary sources. Variables such as key players, sales partners, and distribution networks have an impact on them. The investigation also looks into the scope of each areas research efforts. The total market size for stem cells was computed and validated using revenue and revenue share data from market businesses. The market size of each category was calculated using a top-down approach based on the total market size.

This study provides critical information on the global markets current size and projected growth for stem cells and its related industries. It also discusses geographys market characteristics, significant suppliers, consumer preference trends, and market prospects. As many countries are in a recession, firms are attempting to weather the storm by limiting unanticipated losses and spending related to the stem cells market.

Introduction

Market Overview

Market Segmentation

Regional Analysis

Competitive Analysis

Company Profiles

For Detailed Table of Content: Click Here

Dhirtek Business Research & Consulting Pvt Ltd is a global market research and consulting services provider headquartered in India. We offer our customers syndicated research reports, customized research reports, and consulting services. Our objective is to enable our clientele to achieve transformational progress and help them to make better strategic business decisions and enhance their global presence.

We serve numerous companies worldwide, mobilizing our seasoned workforce to help companies shape their development through proper channeling and execution. We offer our services to large enterprises, start-ups, non-profit organizations, universities, and government agencies. The renowned institutions of various countries and Fortune 500 businesses use our market research services to understand the business environment at the global, regional, and country levels. Our market research reports offer thousands of statistical information and analysis of various industries at a granular level.

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Stem Cells Market by Type (Umbilical Cord Blood Stem Cell, Embryonic Stem Cell, Adult Stem Cell, Other), Application (Diseases Therapy, Healthcare),...

Global Human Embryonic Stem Cell Market To Be Driven By The Rapid Technological Advancements In The Forecast Period Of 2022-2027 – Digital Journal

The new report by Expert Market Research titled, GlobalHuman Embryonic Stem Cell MarketReport and Forecast 2022-2027, gives an in-depth analysis of the global human embryonic stem cell market, assessing the market based on its segments like applications and major regions. The report tracks the latest trends in the industry and studies their impact on the overall market. It also assesses the market dynamics, covering the key demand and price indicators, along with analysing the market based on the SWOT and Porters Five Forces models.

Get a Free Sample Report with Table of Contents:https://www.expertmarketresearch.com/reports/human-embryonic-stem-cell-market/requestsample

The key highlights of the report include:

Market Overview (2017-2027)

Historical Market Size (2020): USD 0.7 billion Forecast CAGR (2022-2027): 10%

The human embryonic stem cell market is being driven by the thriving medical sector. The rising demand for embryonic stem cells can be attributed to the increasing prevalence of chronic diseases around the world owing to the rising adoption of unhealthy and sedentary lifestyle among the youth and middle-class population. The increased risk of premature death as a result of chronic diseases is a growing concern. Therefore, human embryonic stem cells are gaining popularity in the medical sector. Furthermore, the increase in research grants and private as well as public funding for the development of effective and safe stem cell therapy products is further aiding the market growth. The rising investments from key players towards enhancing human embryonic cell therapy is expected to aid the market growth in the forecast period. In post-COVID days, as the various sectors recover from the negative impacts of the pandemic, human embryonic stem cells are likely to witness a rise in demand.

Industry Definition and Major Segments

Human embryonic stem cells, also known as human embryonic stem cells are self-replicating cells derived from human fetal tissue or human embryos that develop into tissues and cells of 3 primary layers. Furthermore, human embryonic stem cells are pluripotent and are roughly 3-5 days old. It is highly versatile, as it may split into new stem cells and even transform into any type of cell in the human body, allowing it to regenerate or repair any diseased organ or tissue.

Read Full Report with Table of Contents:https://www.expertmarketresearch.com/reports/human-embryonic-stem-cell-market

The human embryonic stem cell market, on the basis of application, can be segmented into:

Regenerative Medicine Stem Cell Biology Research Tissue Engineering Toxicology Testing

The regional markets for human embryonic stem cell include:

North America Europe Asia Pacific Latin America Middle East and Africa

Among these, North America represents a significant share of the human embryonic stem cell market.

Market Trends

The rising population along with the rapidly evolving medical infrastructure of emerging economies like India and China is expected to provide an impetus to the human embryonic stem cell market. Furthermore, technological advancements and increasing research and development investments and initiatives are expected to generate opportunities in the market. Researchers and scientists are increasingly leaning toward the transformation of human embryonic stem cells into a number of mature cell types that represent various tissues and organs in the body, as embryonic cells provide unequalled data relating to a variety of disorders. The increasing efforts by the governments of various nations towards enhancing human embryonic stem cell therapy is likely to be another key trend bolstering the market growth in the forecast period.

Key Market Players

The major players in the market Astellas Pharma Inc, Stemcell Technologies Inc., Biotime INC, Thermo Fisher Scientific, Inc., among others. The report covers the market shares, capacities, plant turnarounds, expansions, investments and mergers and acquisitions, among other latest developments of these market players.

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Expert Market Research (EMR) is a leading market research and business intelligence company, ensuring its clients remain at the vanguard of their industries by providing them with exhaustive and actionable market data through its syndicated and custom market reports, covering over 15 major industry domains. The companys expansive and ever-growing database of reports, which are constantly updated, includes reports from industry verticals like chemicals and materials, food and beverages, energy and mining, technology and media, consumer goods, pharmaceuticals, agriculture, and packaging.

EMR leverages its state-of-the-art technological and analytical tools, along with the expertise of its highly skilled team of over 100 analysts and more than 3000 consultants, to help its clients, ranging from Fortune 1,000 companies to small and medium-sized enterprises, easily grasp the expansive industry data and help them in formulating market and business strategies, which ensure that they remain ahead of the curve.

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Global Human Embryonic Stem Cell Market To Be Driven By The Rapid Technological Advancements In The Forecast Period Of 2022-2027 - Digital Journal

Cell Isolation/Cell Separation Market Research Report by Product, Cell Type, Cell Source, Technique, Application, End User, Region – Global Forecast…

New York, May 06, 2022 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Cell Isolation/Cell Separation Market Research Report by Product, Cell Type, Cell Source, Technique, Application, End User, Region - Global Forecast to 2027 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p06260219/?utm_source=GNW

The Global Cell Isolation/Cell Separation Market size was estimated at USD 8,638.55 million in 2021 and expected to reach USD 9,976.06 million in 2022, and is projected to grow at a CAGR 15.66% to reach USD 20,679.59 million by 2027.

Market Statistics: The report provides market sizing and forecast across five major currencies - USD, EUR, JPY, GBP, AUD, CAD, and CHF. It helps organization leaders make better decisions when currency exchange data is readily available. In this report, the years 2019 and 2020 are considered historical years, 2021 as the base year, 2022 as the estimated year, and years from 2023 to 2027 are considered the forecast period.

Market Segmentation & Coverage: This research report categorizes the Cell Isolation/Cell Separation to forecast the revenues and analyze the trends in each of the following sub-markets:

Based on Product, the market was studied across Consumables and Instruments. The Consumables is further studied across Beads, Disposables, and Reagents, Kits, Media, and Sera. The Instruments is further studied across Centrifuges, Filtration Systems, Flow Cytometers, and Magnetic-Activated Cell Separator Systems.

Based on Cell Type, the market was studied across Animal Cells and Human Cells. The Human Cells is further studied across Differentiated Cells and Stem Cells.

Based on Cell Source, the market was studied across Adipose Tissue, Bone Marrow, and Cord Blood/Embryonic Stem Cells.

Based on Technique, the market was studied across Centrifugation-Based Cell Isolation, Filtration-Based Cell Isolation, and Surface Marker-Based Cell Isolation.

Based on Application, the market was studied across Biomolecule Isolation, Cancer Research, In Vitro Diagnostics, Stem Cell Research, and Tissue Regeneration & Regenerative Medicine.

Based on End User, the market was studied across Biotechnology & Biopharmaceutical Companies, Hospitals & Diagnostic Laboratories, and Research Laboratories & Institutes.

Based on Region, the market was studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas is further studied across Argentina, Brazil, Canada, Mexico, and United States. The United States is further studied across California, Florida, Illinois, New York, Ohio, Pennsylvania, and Texas. The Asia-Pacific is further studied across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, Singapore, South Korea, Taiwan, and Thailand. The Europe, Middle East & Africa is further studied across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Cumulative Impact of COVID-19: COVID-19 is an incomparable global public health emergency that has affected almost every industry, and the long-term effects are projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlying COVID-19 issues and potential paths forward. The report delivers insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecasts, considering the COVID-19 impact on the market.

Cumulative Impact of 2022 Russia Ukraine Conflict: We continuously monitor and update reports on political and economic uncertainty due to the Russian invasion of Ukraine. Negative impacts are significantly foreseen globally, especially across Eastern Europe, European Union, Eastern & Central Asia, and the United States. This contention has severely affected lives and livelihoods and represents far-reaching disruptions in trade dynamics. The potential effects of ongoing war and uncertainty in Eastern Europe are expected to have an adverse impact on the world economy, with especially long-term harsh effects on Russia.

This report uncovers the impact of demand & supply, pricing variants, strategic uptake of vendors, and recommendations for Cell Isolation/Cell Separation market considering the current update on the conflict and its global response.

Competitive Strategic Window: The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies to help the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. It describes the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth during a forecast period.

FPNV Positioning Matrix: The FPNV Positioning Matrix evaluates and categorizes the vendors in the Cell Isolation/Cell Separation Market based on Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Market Share Analysis: The Market Share Analysis offers the analysis of vendors considering their contribution to the overall market. It provides the idea of its revenue generation into the overall market compared to other vendors in the space. It provides insights into how vendors are performing in terms of revenue generation and customer base compared to others. Knowing market share offers an idea of the size and competitiveness of the vendors for the base year. It reveals the market characteristics in terms of accumulation, fragmentation, dominance, and amalgamation traits.

Competitive Scenario: The Competitive Scenario provides an outlook analysis of the various business growth strategies adopted by the vendors. The news covered in this section deliver valuable thoughts at the different stage while keeping up-to-date with the business and engage stakeholders in the economic debate. The competitive scenario represents press releases or news of the companies categorized into Merger & Acquisition, Agreement, Collaboration, & Partnership, New Product Launch & Enhancement, Investment & Funding, and Award, Recognition, & Expansion. All the news collected help vendor to understand the gaps in the marketplace and competitors strength and weakness thereby, providing insights to enhance product and service.

Company Usability Profiles: The report profoundly explores the recent significant developments by the leading vendors and innovation profiles in the Global Cell Isolation/Cell Separation Market, including Akadeum Life Sciences, Inc., Alfa Laval, Beckman Coulter Inc., Becton, Dickinson and Company, Bio Legend, Bio- Techne, Bio-Rad Laboratories, Inc., Cell Biologics, Inc. A, Cell Microsystems, cellenion SASU, Corning Inc., GE Healthcare, Invent Biotechnologies, Lonza, Merck KGaA, Miltenyl Biotech, Omega Bio-tek, Inc., pluriSelect Life Science, Pluriselect Life Science Ug (Haftungsbeschrnkt) & Co. Kg, REPROCELL Inc., Roche Diagnostics, Stemcell Technologies, Inc., Terumo Bct, and Thermo Fisher Scientific, Inc..

The report provides insights on the following pointers: 1. Market Penetration: Provides comprehensive information on the market offered by the key players 2. Market Development: Provides in-depth information about lucrative emerging markets and analyze penetration across mature segments of the markets 3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments 4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, certification, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players 5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and breakthrough product developments

The report answers questions such as: 1. What is the market size and forecast of the Global Cell Isolation/Cell Separation Market? 2. What are the inhibiting factors and impact of COVID-19 shaping the Global Cell Isolation/Cell Separation Market during the forecast period? 3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Cell Isolation/Cell Separation Market? 4. What is the competitive strategic window for opportunities in the Global Cell Isolation/Cell Separation Market? 5. What are the technology trends and regulatory frameworks in the Global Cell Isolation/Cell Separation Market? 6. What is the market share of the leading vendors in the Global Cell Isolation/Cell Separation Market? 7. What modes and strategic moves are considered suitable for entering the Global Cell Isolation/Cell Separation Market? Read the full report: https://www.reportlinker.com/p06260219/?utm_source=GNW

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Cell Isolation/Cell Separation Market Research Report by Product, Cell Type, Cell Source, Technique, Application, End User, Region - Global Forecast...

Why haven’t we cloned a human yet? – Livescience.com

In 1996, Dolly the sheep made headlines around the world after becoming the first mammal to be successfully cloned from an adult cell. Many commentators thought this would catalyze a golden age of cloning, with numerous voices speculating that the first human clone must surely be just a few years away.

Some people suggested that human clones could play a role in eradicating genetic diseases, while others considered that the cloning process could, eventually, eliminate birth defects (despite research by a group of French scientists in 1999 finding that cloning may actually increase the risk of birth defects).

There have been various claims all unfounded, it is important to add of successful human cloning progams since the success of Dolly. In 2002, Brigitte Boisselier, a French chemist and devout supporter of Ralism a UFO religion based on the idea that aliens created humanity claimed that she and a team of scientists had successfully delivered the first cloned human, whom she named Eve.

However, Boisselier was unwilling or indeed unable to provide any evidence, and so it is widely believed to be a hoax.

So why, almost 30 years on from Dolly, haven't humans been cloned yet? Is it primarily for ethical reasons, are there technological barriers, or is it simply not worth doing?

Related: What are the alternatives to animal testing?

"Cloning" is a broad term, given it can be used to describe a range of processes and approaches, but the aim is always to produce "genetically identical copies of a biological entity," according to the National Human Genome Research Institute (NHGRI).

Any attempted human cloning would most likely utilize "reproductive cloning" techniques an approach in which a "mature somatic cell," most probably a skin cell, would be used, according to NHGRI. The DNA extracted from this cell would be placed into the egg cell of a donor that has "had its own DNA-containing nucleus removed."

The egg would then begin to develop in a test tube before being "implanted into the womb of an adult female," according to NHGRI.

However, while scientists have cloned many mammals, including cattle, goats, rabbits and cats, humans have not made the list.

"I think there is no good reason to make [human] clones," Hank Greely, a professor of law and genetics at Stanford University who specializes in ethical, legal and social issues arising from advances in the biosciences, told Live Science in an email.

"Human cloning is a particularly dramatic action, and was one of the topics that helped launch American bioethics," Greely added.

The ethical concerns around human cloning are many and varied. According to Britannica, the potential issues encompass "psychological, social and physiological risks." These include the idea that cloning could lead to a "very high likelihood" of loss of life, as well as concerns around cloning being used by supporters of eugenics. Furthermore, according to Britannica, cloning could be deemed to violate "principles of human dignity, freedom and equality."

In addition, the cloning of mammals has historically resulted in extremely high rates of death and developmental abnormalities in the clones, Live Science previously reported.

Another core issue with human cloning is that, rather than creating a carbon copy of the original person, it would produce an individual with their own thoughts and opinions.

"We've all known clones identical twins are clones of each other and thus we all know that clones aren't the same person," Greely explained.

A human clone, Greely continued, would only have the same genetic makeup as someone else they would not share other things such as personality, morals or sense of humor: these would be unique to both parties.

People are, as we well know, far more than simply a product of their DNA. While it is possible to reproduce genetic material, it is not possible to exactly replicate living environments, create an identical upbringing, or have two people encounter the same life experiences.

So, if scientists were to clone a human, would there be any benefits, scientific or otherwise?

"There are none that we should be willing to consider," Greely said, emphasizing that the ethical concerns would be impossible to overlook.

However, if moral considerations were removed entirely from the equation, then "one theoretical benefit would be to create genetically identical humans for research purposes," Greely said, though he was keen to reaffirm his view that this should be thought of as "an ethical non-starter."

Greely also stated that, regardless of his own personal opinion, some of the potential benefits associated with cloning humans have, to a certain degree, been made redundant by other scientific developments.

"The idea of using cloned embryos for purposes other than making babies, for example producing human embryonic stem cells identical to a donor's cells, was widely discussed in the early 2000s," he said, but this line of research became irrelevant and has subsequently not been expanded upon post-2006, the year so-called induced pluripotent stem cells (iPSCs) were discovered. These are "adult" cells that have been reprogrammed to resemble cells in early development.

Shinya Yamanaka, a Japanese stem cell researcher and 2012 Nobel Prize winner, made the discovery when he "worked out how to return adult mouse cells to an embryonic-like state using just four genetic factors," according to an article in Nature. The following year, Yamanaka, alongside renowned American biologist James Thompson, managed to do the same with human cells.

When iPSCs are "reprogrammed back into an embryonic-like pluripotent state," they enable the "development of an unlimited source of any type of human cell needed for therapeutic purposes," according to the Center of Regenerative Medicine and Stem Cell Research at the University of California, Los Angeles.

Therefore, instead of using embryos, "we can effectively do the same thing with skin cells," Greely said.

This development in iPSC technology essentially rendered the concept of using cloned embryos both unnecessary and scientifically inferior.

Related: What is the most genetically diverse species?

Nowadays, iPSCs can be used for research in disease modeling, medicinal drug discovery and regenerative medicine, according to a 2015 paper published in the journal Frontiers in Cell and Developmental Biology.

Additionally, Greely also suggested that human cloning may simply no longer be a "sexy" area of scientific study, which could also explain why it has seen very little development in recent years.

He pointed out that human germline genome editing is now a more interesting topic in the public's mind, with many curious about the concept of creating "super babies," for example. Germline editing, or germline engineering, is a process, or series of processes, that create permanent changes to an individuals genome. These alterations, when introduced effectively, become heritable, meaning they will be handed down from parent to child.

Such editing is controversial and yet to be fully understood. In 2018, the Council of Europe Committee on Bioethics, which represents 47 European states, released a statement saying that "ethics and human rights must guide any use of genome editing technologies in human beings," adding that "the application of genome editing technologies to human embryos raises many ethical, social and safety issues, particularly from any modification of the human genome which could be passed on to future generations."

However, the council also noted that there is "strong support" for using such engineering and editing technologies to better understand "the causes of diseases and their future treatment," noting that they offer "considerable potential for research in this field and to improve human health."

George Church, a geneticist and molecular engineer at Harvard University, supports Greely's assertion that germline editing is likely to garner more scientific interest in the future, especially when compared with "conventional" cloning.

"Cloning-based germline editing is typically more precise, can involve more genes, and has more efficient delivery to all cells than somatic genome editing," he told Live Science.

However, Church was keen to urge caution, and admitted that such editing has not yet been mastered.

"Potential drawbacks to address include safety, efficacy and equitable access for all," he concluded.

Originally published on Live Science.

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Why haven't we cloned a human yet? - Livescience.com

Christian leaders and controversies: The case of Francis Collins – The Christian Post

National Institutes of Health Director Francis Collins speaks at the 2019 BioLogos Conference in Baltimore, Maryland on March 27, 2019. | THE CHRISTIAN POST

There is always a dilemma for Christians in best handling and reacting to the positions and counsel of Christian leaders. Often these are people we have grown to trust and respect as followers of Christ.

Their convictions at times are consistent with Christian principles and biblical wisdom. They champion appropriate positions and defend causes from a historically Christian perspective. They gain traction and respect even among cultural, political, and religious opponents because of the internally consistent strength of their arguments and their winsome and gracious demeanor.

And yet, it is impossible for any fallen and sinful person to be right all the time. Similarly, it is quite possible and regularly demonstrated that the unregenerate are not always wrong.

As a case in point, contrast Dr. Francis Collins and President Donald Trump.

Trump, not convincingly a born-again Christian, became president in large measure because he promised to represent conservative Christians and their concerns. His appointing of originalist judges to federal courts and the U.S. Supreme Court, as well as his attendance at events like the annual March for Life while he was in office (this was unprecedented for a president), were encouragements to many Christians. Yet his demeanor was consistently characterized as non-Christian. Such may well have cost him re-election. Christians and conservative political analysts will debate for decades whether he was a net positive or negative influence on America. Clearly, both cases can be made. Different Christian voices have weighed in on the matter. Many Christians, even conservatives, felt that Trump used them for his personal gain and prestige.

In certain notable ways, a case could be made that the Francis Collins situation at times echoes the debate over Donald Trump among Christians.

Dr. Francis Collins, the famous geneticist, was and is vocally Christian. He has clearly identified as such, and he has taken heat for it. For example, in the summer of 2009, after his nomination as director of NIH by President Barack Obama, outspoken atheist Sam Harris attacked Collins in theNew York Timesas unfit for the job because of his religious convictions.

Collins became known to many Americans during his direction of the Human Genome Project through the 1990s. In February 1998,Scientific Americanprofiled Dr. Collins with the headline Where Science and Religion meet: The U.S. head of the Human Genome Project, Francis S. Collins, stives to keep his Christianity from interfering with his science and politics. That article quoted Dr. Collins saying he is intensely uncomfortable with abortion. He said that he does not advocate changing the law and is very careful to ensure his personal feelings on abortion do not affect his political stance.

The article went on to say: researchers and academics familiar with Collins work agree that he has separated his private religious views from his professional life. He shows no influence of religious beliefs on his work other than a generalized sensitivity to ethics issues in genetics.

In essence, what these people were saying is that Francis Collins is such a good scientist because you can hardly tell he is a Christian from his work.

As a much younger biology professor at the time, I was aghast at this. A Christian has separated his religious views from his professional life. Why is that a good thing?

I emailed Dr. Collins at the time, asking him ifScientific Americanhad it right. Maybe the article misunderstood Collins? My email was never answered. Not that I expected that it would be, given my obscurity and his standing and responsibilities. Still, the article troubled me, as I was always left with the lingering question.

Dr. Collins went on to launch the BioLogos Foundation, a Christian/science interface organization that advocates for the reconciliation of modern science and Christianity. The idea is that nature and Scripture are both from God and ultimately are not in conflict. This reflects Dr. Collins Christian convictions and his love of science, the study of Gods physical world. Give Dr. Collins credit for leveraging his popularity, leadership qualities, and obvious pastoral instincts for the noble cause.

Ultimately, I met Dr. Collins several years ago at a conference and heard him speak. There is no reason he would remember our quick contact in an elevator any more than he would remember my email. However, one cannot help but be impressed by his genuine humility and his concern for the spiritual health of the people around him. He has made it clear that he believes that Jesus Christ is incarnate and divine and that humans are made in the image of God (although he rejects the historic Adam), and that salvation is real.

Yet, inconsistencies remain. Dr. Collins seems to allow his science to inordinately arbitrate over biblical truth, or at least when the two are portrayed as in conflict. As his professional life has unfolded, it has become clear that theScientific Americanarticle had gotten a lot right. It is fair to say that he has remained uncertain about when human life begins. He concedes that the fertilized egg is alive at conception, but believes that maybe it is not quite human. Consequently, in his 2010 book,The Language of Life,he advocated for experimentation using excess human embryos fromin vitro fertilization(IVF) that are stuck in cryo-storage with uncertain futures, so that some good could come from them. He has never publicly disavowed human embryonic research because he sees its potential fruitfulness. In fact, as late as last summer, experiments involving human embryonic cells and mice was supported by NIH funding at the University of Pittsburgh.

There are ongoing ramifications of Dr. Collins acceptance of abortion as the law of the land. TheScientific Americanarticle in 1998 mentioned that Dr. Collins was concerned that embryonic genetic testing might lead to abortions of fetuses that have conditions that are less than disastrous. The article did not suggest what he would consider less than disastrous. For instance, would my great-nephews Downs syndrome condition be considered less than a disaster?

Princeton bioethicist and legal scholar, Dr. Robert George, made a clearer case in his 1998 address to the American Political Science Association Convention, stating, once I was a child, once I was an infant, once I was an embryo, I cannot say I was once an egg or a sperm. However, it is clear that the viable sperm and egg are quite alive. Also, it is good to remember what we say in the Apostles Creed. He was conceived born suffered died and rose again.

What human is not on that trajectory of life and death? The Bible teaches that we all are.

This leaves many conservative Christians convinced that Dr. Collins would rather come down on the side of a quote from his old boss, President Barack Obama. In March 2009, Obama signed an executive order that lifted President George W. Bushs 2001 ban on federal funding of human embryonic research. Today we will lift the ban on federal funding for promising embryonic stem cell research, stated Obama. We will vigorously support scientists who pursue this research. And we will aim for America to lead the world in the discoveries it one day may yield. Obama continued, Promoting science isnt just about providing resources it is also about protecting free and open inquiry. It is about letting scientists like those here today do their jobs, free from manipulation or coercion, and that we make scientific decisions based on facts, not ideology.

Obama insisted that Im going to let scientists do science. Im going to remove politics, religion, and ideology from that.

Of course, the reality is that such a thing cannot be done. The presidents own politics and ideology were clearly stated and inserted.

One would hope that Dr. Collins would be more comfortable with the principles articulated in President George W. Bushs 2006 State of the Union Address. A hopeful society has institutions of science and medicine that do not cut ethical corners, and that recognize the matchless value of every life, stated Bush. Tonight, I ask you to pass legislation to prohibit the most egregious abuses of medical research human cloning in all its forms creating or implanting embryos for experiments creating human-animal hybrids and buying, selling, or patenting human embryos. Human life is a gift from our Creatorand that gift should never be discarded, devalued, or put up for sale.

These are all ethical issues that have confronted Dr. Francis Collins as a man of science and of faith. The issues more recently included COVID mask and vaccine mandates. To many in the evangelical community, the pro-life appeals he made for the mandates have rung increasingly hollow, and his seeming inconsistencies have been bothersome.

Os Guinness, in his book,The Magna Carta of Humanity, brings out a principle that every intentional Christian should keep in mind: The notion of arguing on behalf of the true, the right, and the good lies behind the biblical principle of corrigibility. Guinness quotes Jewish Hebrew scholar Jonathan Sacks, We are all open to challenge. No one is above criticism, no one is too junior to administer it, if done with due grace and humility.

This requires knowing scripture and applying its logical conclusions, consistently. Otherwise, our ability to be salt and light is diminished, and we can be played. Francis Collins needs to add salt and light. Many of us have admired him, and we expect more from him in his Christian witness to science.

Dr. Jan Dudt is a professor of biology at Grove City College and fellow for medical ethics with the Institute for Faith & Freedom. He teaches as part of colleges required core course Studies in Science, Faith and Technology wherein students, among other things, study all the major origins theories and are asked to measure them in the light of biblical authority.

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Christian leaders and controversies: The case of Francis Collins - The Christian Post

Alzheimer’s Drugs Market Size worth US$ ~9.67 billion by 2031: Exclusive Report by Growth Plus Reports – PR Newswire

NEW YORK, May 10, 2022 /PRNewswire/ --The Global Alzheimer's Drugs Market Size is expected to clock US$ ~9.67 billion by 2031, according to the latest report published by Growth Plus Reports. Owing to the rising prevalence of Alzheimer's disease coupled with a strong product pipeline.

Growth Factor

The prominent players are progressively implementing collaborative initiatives with several organizations, research centers, and companies in order to encourage R&D of Alzheimer's treatment. For instance, in February 2020, Biogen Inc. and Sangamo Therapeutics, Inc. entered into a global licensing collaboration agreement to develop and commercialize ST-501 for tauopathies including Alzheimer's disease.

The global Alzheimer's drugs market has been analyzed from three different perspectivesDrug Type, Distribution Channel, and Region.

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Government bodies and numerous organizations across the globe are taking initiatives to fast-track the development of Alzheimer's drug by providing the necessary funding and approvals. For instance, federal funding for USC's research on Alzheimer's disease and related dementias grew by more than 400% between 2015 and 2018. USC's NIH funding for Alzheimer's was $13.3 million in 2015 and it increased to $68.3 million in 2018.

Alzheimer's is the fifth-leading cause of death among those aged 65 & older and is also a leading cause of disability & poor health. An estimated 5.8 million Americans aged 65 and older were living with Alzheimer's dementia in 2020. 80% of this population was aged 75 or older. This number is expected to increase to 13.5 million by 2050. Among people of age 70, 61% of those with Alzheimer's dementia are expected to die before the age of 80 compared with 30% of people without Alzheimer's. The rising prevalence of Alzheimer's disease has increased the demand for the treatment, which in turn is expected to boost the market growth.

Restraints:

Alzheimer's drug development is considered to have the highest failure rates of all drug research, at 99.6% compared to 81% for cancer, according to Scientific American. The drug development process includes high capital investments, therefore, failures in drug research may prove to be huge loss for companies, thereby discouraging the companies to invest and participate in the clinical trials. In January 2018, Pfizer, announced to end its R&D on new drugs for Alzheimer's and Parkinson's diseases and reallocate the funding to areas where the company has strong scientific leadership. Pfizer is among the first companies to research Alzheimer's. Such instances are expected to slow down the growth of the market.

Excerpts from 'By Drug Type Segmentation'

The global Alzheimer's drugs market has been segmented majorly into three distinct categories depending on drug type, viz.

The NMDA receptor antagonists segment consists of Memantine drug. Whereas cholinesterase inhibitors consists of Galantamine, Rivastigmine, and Donepezil drugs. The cholinesterase inhibitors segment dominated the market with the largest share in 2020. The growth of the segment can be attributed to the use of cholinesterase inhibitors as a first line treatment for mild to moderate Alzheimer's condition.

Excerpts from 'By Region Segmentation'

The global Alzheimer's drugs market has been segmented into North America, Europe, Asia Pacific, and the Rest of the World (RoW).

North America is expected to command the largest share in the global Alzheimer's Drugs market in 2020, followed by the Asia Pacific, Europe and Rest of the World (RoW). Factors such as rising prevalence of Alzheimer's among geriatric population, rising initiatives by various public and private organizations, and presence of the prominent players coupled with large number of drugs present in pipeline are attributed for the large share of the region in the global market.

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Excerpts from 'Competitive Landscape'

The prominent players operating in the global Alzheimer's drugs market are: -

Alzheimer's DrugsMarket Segmentation

Growth Plus Reports has segmented the global Alzheimer's Drugs market on the basis Drug Type, Distribution Channel, and Region:

Drug Type Outlook:

Distribution Channel Outlook:

Region Outlook:

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Alzheimer's Drugs Market Size worth US$ ~9.67 billion by 2031: Exclusive Report by Growth Plus Reports - PR Newswire