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Alphageneron Pharmaceuticals Signed Exclusive License Agreement With Multimmune GmbH For Natural Killer Cell Platform Therapy Worldwide

By Global News Feed

CAMBRIDGE, Mass., Feb. 04, 2021 (GLOBE NEWSWIRE) -- Alphageneron Pharmaceuticals, Inc., (Alphageneron) signed an Exclusive License Agreement with Multimmune GmbH, of Munich, Germany, (Multimmune) on October 1st, 2020, for its clinical stage autologous Natural Killer (“NK”) cell therapy and companion diagnostic platform, for all fields worldwide.

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Alphageneron Pharmaceuticals Signed Exclusive License Agreement With Multimmune GmbH For Natural Killer Cell Platform Therapy Worldwide

EyePoint Pharmaceuticals Announces Closing of $115 Million Public Offering of Common Stock

By Global News Feed

WATERTOWN, Mass., Feb. 04, 2021 (GLOBE NEWSWIRE) -- EyePoint Pharmaceuticals, Inc. (NASDAQ: EYPT), a pharmaceutical company committed to developing and commercializing therapeutics to help improve the lives of patients with serious eye disorders, today announced the closing of an underwritten public offering of 10,465,000 shares of its common stock at a public offering price of $11.00 per share, including the exercise in full by the underwriters of their option to purchase up to 1,365,000 additional shares of common stock. The gross proceeds of the offering to the Company are approximately $115.1 million, before deducting the underwriting discounts and commissions and other estimated offering expenses.

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EyePoint Pharmaceuticals Announces Closing of $115 Million Public Offering of Common Stock

PRA Health Sciences to Report Fourth Quarter and Full Year 2020 Earnings

By Global News Feed

RALEIGH, N.C., Feb. 04, 2021 (GLOBE NEWSWIRE) -- PRA Health Sciences, Inc. (NASDAQ: PRAH) will release its fourth quarter and full year 2020 results after the market closes on Thursday, February 25, 2021. The Company will also host a conference call on Friday, February 26, 2021 at 9:00 a.m. (ET) to discuss the results with members of the investment community.

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PRA Health Sciences to Report Fourth Quarter and Full Year 2020 Earnings

Stem Cells Market Value to Reach Around USD 17.79 Bn by 2027 – GlobeNewswire

By Adult Stem Cells

February 04, 2021 08:57 ET | Source: Precedence Research

OTTAWA, Feb. 04, 2021 (GLOBE NEWSWIRE) -- The global stem cells market garnered revenue around USD 9.25 billion in 2019, according to new report study by Precedence Research.

Stem cells are also called as tissue specific and can renew themselves via mitotic cell division and differentiating into an assorted range of specialized cell type. Stem cells are found in all human being, from the early stages of human development to the end of life. Human body contains stem cells and may use it whenever required. These are used to develop the adult stem cells present in the body from the development of an embryo. Cord blood processing and storage together with automation in adult stem cell are the pointer technologies anticipated to positively impact the growth of the adult cord blood stem cells market. The existence of stem cell-based treatments has been established as a clinical standard of care for different conditions such as epithelial stem cell-based therapy for burns as well as corneal disorders and hematopoietic stem cell transplant for leukemia. The potential stem cell-based therapies have expanded owing to advances in stem cell-based research.

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Growth factors

Since past few years, stem cells market is growing with the increasing investment in stem cell-based research by biopharmaceutical and pharmaceutical firm along with the success of regenerative medicines. Stem cells market is growth is backed by escalating number of clinical trials across the world. Some of the major factors driving the growth of the stem cells market include advancement in stem cell manufacturing technology as well as increasing harvest awareness regarding therapeutic potency. High occurrences of infections have steered the development of vaccines using various human diploid and non-tumorigenic cell lines.

Growing demands as well as awareness along with ongoing research and development of vaccines against different diseases are certain growth influencers of the stem cells market. Additionally, prevalence of chronic diseases will also fuel the market growth. Presence of advanced stem cells banking and availability of stem cells donor will significantly boost the market demand during upcoming years. Rigorous support of government via different initiatives aids stem cells banking to obtain significance. Increasing number of stem cells banks in emerging economies is further encouraging market penetration. Also, growing awareness about stem cell harvest which holds high potential in therapeutic and diagnosis field offers lucrative prospects to the market during impending years.

Intensifying prevalence of cancer worldwide is offering substantial boost to the growth of cancer stem cells market. As per the data published by World Health Organization, the global cancer implication is projected to have risen to around 18 million latest cases and around 9.2 million deaths in year 2018. Additionally, according to Cancer Research UK, the population enduring the cancer is anticipated to grow in near future.

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Report Highlights

Regional Snapshot

North America held the largest share in the market and is anticipated to continue its dominance over the forecast period due to existence of organized and developed healthcare systems which uplift research and development in the U.S. and Canada. Asia Pacific is likely to grow with the highest Compound Annual Growth Rate (CAGR) owing to wide usage of stem cells in regenerative medicines particularly in the sector of dermatology. Oncology applications are expected to grow at highest CAGR owing to large number of pipeline products available for the cure of cancer and tumors. Growing number of regenerative medicines centers are in turn expected to drive the stem cell in near future.

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Key Players & Strategies

Stem Cells market is highly competitive and includes several major players such as STEMCELL Technologies, Inc., Osiris therapeutics, Inc., Cynata Therapeutics, Human Longevity, Inc., Advanced Cell Technology, Inc., BIOTIME, Inc.Mesoblast Limited, Promethera Biosciences S.A. N.V., Merck Group, Takara Bio Group. Prominent market giants are emphasizing on product development and improvement which is increasing overall competition in the market.

In January 2019, The Cesca Therapeutics acquired ThermoGenesis Corp., and formed new wholly-owned ThermoGenesis subsidiary in order to focus on its Car-TXpress cellular processing platform. This acquisition was directed at commercializing and developing automated technologies as well as medical devices integrated in the therapies.

Market Segmentation

By Product

By Application

By Technology

By Therapy

By Regional Outlook

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Stem Cells Market Value to Reach Around USD 17.79 Bn by 2027 - GlobeNewswire

Global Adult Stem Cells Market Revenue To Witness Humongous Elevation By 2026 Market Research Store Jumbo News – Jumbo News

By Adult Stem Cells

Global Adult Stem Cells Market Witnesses Significant Growth Amid The Latest COVID-19 Pandemic Crisis

The globalAdult Stem Cells marketstudy maps the growth trajectory of the global Adult Stem Cells market by accurately evaluating all the vital factors that have a positive impact on the market growth. The Adult Stem Cells market report is expected to attain an accelerated growth and attain future prospects through the assessment of various facets of the Adult Stem Cells market. According to the report published by theMarket Research Store, the Adult Stem Cells market is predicted to attain vigorous momentum in its growth during the forecast owing to the increasing consumer base and market profiting growth stimulators.

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This report provides all the information regarding market drivers, challenges, opportunities, future scope, and recent developments of theAdult Stem Cells marketonly after a thorough evaluation. Furthermore, to make the report more understandable to the readers it starts with a complete market overview that makes scrolling through the entire content a seamless experience.

The section focusing on competitive landscape of the report help better understand the shoulder to shoulder competition among the major players in the global Adult Stem Cells market. The company profiles provide intense insight of product portfolio, sales strategies, marketing & advertising skills, and distribution analysis of each market player. Some of the leading players evaluated in the report includeGamida Cell Ltd., Clontech, Globalstem, Celyad, Cellular Dynamics International, Epistem Ltd., Biotime Inc., Intellicell Biosciences Inc., Neuralstem, Juventas Therapeutics Inc., Hybrid Organ Gmbh, Cellerant Therapeutics Inc., Beike Biotechnology Co. Ltd., Caladrius Biosciences Inc., Capricor Inc., Neurogeneration, Cellerix Sa, Brainstorm Cell Therapeutics Inc., Mesoblast Ltd., International Stem Cell Corp., Cytori Therapeutics Inc..

Similarly, an exhaustive geographical analysis of the global Adult Stem Cells market covers market attracted regions including North & South America (United States, Mexico, Canada, Brazil, Argentina, Chile, etc.), Europe (Italy, Germany, Russia, UK, Turkey, France, etc.), The Middle East and Africa (South Africa, Sudan, GCC Countries, Egypt, etc.), Asia-Pacific (China, Malaysia, Japan, Vietnam, Singapore, Korea, India, Indonesia, and Australia). The regional market attractiveness helps better understand the market status, accurate statistics, product demand, and overall market revenue. On the whole, the report will provide valid market data that will offer a cutting edge to the investors wanting to invest in the global Adult Stem Cells market. The market report offers accurate and comprehensive assessment of the micro and macro-economic factors and market valuation details that are forecasted to impact the market growth.

Critical aspects provided in the report:

Supply/demand chain analysis, market size, market volume, market revenue, and product pricing analysis Future scope, recent developments, new product launches, and opportunities Market challenges and risks that hinder market growth Progress in terms of product development and innovation Analysis of key competitive players Market attractiveness in various countries/regions

Adult Stem Cells Market, By Product (2020-2026)

Epithelial stem cells, Hematopoietic stem cells

Adult Stem Cells Market, By Application/End-use (2020-2026)

Neurodegenerative diseases, Heart disease, Bone disease, Others

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New approaches and latest development trend that describe the structure of the market Advanced market breakdown structure Historical data and future market scope In-depth market analysis based on statistics, growth stimulators, and market developments Statistical data representation through figurative, numerical, and theoretical elaboration Report provides insight of the business and sales activities Key competitive players and regional distribution will help find prospective market analytics Report will strengthen the investors decision-making processes

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Global Adult Stem Cells Market Revenue To Witness Humongous Elevation By 2026 Market Research Store Jumbo News - Jumbo News

Reactivation of the pluripotency program precedes formation of the cranial neural crest – Science Magazine

By Embryonic Stem Cells

Reactivating neural crest pluripotency

Cranial neural crest cells (CNCCs) are a transient cell group with an extraordinary differentiation potential that extends beyond its ectodermal lineage to form the majority of facial mesenchyme. Zalc et al. identified a neuroepithelial precursor population that transiently reactivates pluripotency factors to generate CNCCs. The pluripotency factor Oct4 is required for the expansion of CNCC developmental potential to form facial mesenchyme. Analysis of the chromatin landscape of Oct4+ CNCC precursors showed that these cells resemble those of epiblast stem cells, with additional features suggestive of future priming for neural crest programs. Thus, to expand their cellular potency, CNCC precursors undergo a natural in vivo reprogramming event.

Science, this issue p. eabb4776

Cell differentiation is classically described as a unidirectional process that progresses through a series of lineage restriction events, with cellular potential being increasingly reduced as the embryo develops, a concept famously illustrated by Conrad Waddington in his epigenetic landscape. However, the vertebrate-specific transient cell population called cranial neural crest cells (CNCCs) challenges this paradigm. Although they originate in the ectoderm and are capable of differentiating into cell types typical of this germ layer, CNCCs can also give rise to mesenchymal cell types canonically associated with the mesoderm lineage, such as bone, cartilage, and smooth muscle. How CNCCs expand their differentiation potential beyond their germ layer of origin remains unresolved.

We hypothesized that unbiased analysis of transcriptional heterogeneity during the early stages of mammalian CNCC development may identify a precursor population and provide clues as to how these specialized cells gain their extraordinary differentiation potential. To test this, we combined single-cell RNA-sequencing analysis of murine CNCCs from staged mouse embryos with follow-up lineage-tracing, loss-of-function, and epigenomic-profiling experiments.

We found that premigratory CNCCs are heterogeneous and carry positional information reflective of their origin in the neuroepithelium, but this early positional information is subsequently erased, with delaminating CNCCs showing a relatively uniform transcriptional signature that later rediversifies as CNCCs undergo first commitment events. We identify an early precursor population that expresses canonical pluripotency transcription factors and gives rise to CNCCs and craniofacial structures. Rather than being maintained from the epiblast, pluripotency factor Oct4 is transiently reactivated in the prospective CNCCs after head-fold formation, and its expression shifts from the most anterior to the more posterior part of the cranial domain as development progresses. Oct4 is not required for the induction of CNCCs in the neuroepithelium, but instead is important for the specification and survival of facial mesenchyme, thus directly linking this pluripotency factor with the expansion of CNCC cellular potential. Open chromatin landscapes of Oct4+ CNCC precursors are consistent with their neuroepithelial origin while also broadly resembling those of pluripotent epiblast stem cells. In addition, we saw priming of distal regulatory regions at a subset of loci associated with future neural crest migration and mesenchyme formation.

Our results show that premigratory CNCCs first form as a heterogeneous population that rapidly changes its transcriptional identity during delamination, resulting in the formation of a transcriptionally (and likely also functionally) equivalent cell group capable of adapting to future locations during and after migration. Such functional equivalency and plasticity of CNCCs is consistent with previous embryological studies. Furthermore, the demonstration that CNCC precursors transiently reactivate pluripotency factors suggests that these cells undergo a natural in vivo reprogramming event that allows them to climb uphill on Waddingtons epigenetic landscape. Indeed, our results show that at least one of the pluripotency factors, Oct4, is required for the expansion of CNCC developmental potential to include formation of facial mesenchyme. Whether this mechanism is specific to CNCCs and if such expansion of cellular plasticity could be harnessed for regenerative medicine purposes remain interesting questions for future investigations.

(A) Single-cell RNA (scRNA) sequencing of genetically labeled murine CNCCs over 14 hours of development revealed rapid transcriptional changes and identified a precursor population expressing pluripotency factors. (B) Uphill on Waddingtons epigenetic landscape, reactivation of Oct4 endows CNCC precursors with the ability to form derivatives typical of mesoderm, such as mesenchyme.

During development, cells progress from a pluripotent state to a more restricted fate within a particular germ layer. However, cranial neural crest cells (CNCCs), a transient cell population that generates most of the craniofacial skeleton, have much broader differentiation potential than their ectodermal lineage of origin. Here, we identify a neuroepithelial precursor population characterized by expression of canonical pluripotency transcription factors that gives rise to CNCCs and is essential for craniofacial development. Pluripotency factor Oct4 is transiently reactivated in CNCCs and is required for the subsequent formation of ectomesenchyme. Furthermore, open chromatin landscapes of Oct4+ CNCC precursors resemble those of epiblast stem cells, with additional features suggestive of priming for mesenchymal programs. We propose that CNCCs expand their developmental potential through a transient reacquisition of molecular signatures of pluripotency.

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Reactivation of the pluripotency program precedes formation of the cranial neural crest - Science Magazine

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