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Stem Cell Cartilage Regeneration Market : Revenue, Growth, Business Outlook & Forecast 2020-2029 – PharmiWeb.com

Pune, Maharashtra, India, December 30 2020 (Wiredrelease) MarketResearch.Biz :Marketresearch.biz added a new report Global Stem Cell Cartilage RegenerationMarket along with its Industry Analysis, Size, Share, Growth, Trends and Forecast2020 2029, which provides an in-depth analysis of key business trends with future market development prospects, key drivers, restraints, profiles of key market players, segmentation and forecasting.

Global Stem Cell Cartilage Regeneration Market report offers a complete overview of the Stem Cell Cartilage Regeneration Market. The Report also presents real data, statistics, and improvements in global Stem Cell Cartilage Regeneration Markets. It also highlights the supply, demand, manufacturing abilities, latest innovations, and the markets unstable structure. Global Stem Cell Cartilage Regeneration Market report elaborates on the crucial data and important insights related to the current market status.

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This report additionally provides the SWOT analysis for all companies profiled in the Stem Cell Cartilage Regeneration report and also consists of various competitors profiles, competitive scenarios, opportunities, and market of geographical regions. The geographical regions covered in the Stem Cell Cartilage Regeneration report are North America, Europe, Asia-Pacific, Australia, and the rest of the globe.

Note To provide a more accurate market forecast, our industry experts will provide information considering the ongoing pandemic (COVID-19) and its effects on the Stem Cell Cartilage Regeneration market.

Download the Complete Information Of COVID 19 Impact On Stem Cell Cartilage Regeneration Market

Key Players for the Stem Cell Cartilage Regeneration market around the world are:

Theracell (Laboratories), Orthocell Limited, Xintela AB (publ), CellGenix GmbH, Merck KGaA, Osiris Therapeutics Inc, BioTissue Technologies GmbH, Vericel Corporation, Smith & Nephew plc, EMD Serono Inc

The main goal of providing this information is to give a descriptive analysis of how the trends could potentially affect the upcoming future of the Stem Cell Cartilage Regeneration market during the given forecast period 2019-2029. This markets competitive manufactures and the upcoming manufactures are studied with their detailed research, revenue, production, price, market share of these players is mentioned with their precise information.

Reasons for Buying the Stem Cell Cartilage Regeneration Report is:

Report provides a pin-point analysis for changing competitive dynamics keeping in mind the effect of COVID-19.

It provides a forward-looking perspective on different factors driving or restraining the Stem Cell Cartilage Regeneration market growth.

Mentioned forecast assessed based on how the Stem Cell Cartilage Regeneration market is predicted to grow.

It helps in understanding the key product segments and their future.

It provides a point-point analysis of changing competition dynamics and keeps you ahead of your competitors.

It helps make informed business decisions by having complete insights into the market and making in-depth analysis of market segments.

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Regional Segment Analysis:

The report provides accurate analysis for changing competitive dynamics in the market, offering a forward-looking perspective on different factors driving or limiting the market growth. Given the forecast assessed based on how the Stem Cell Cartilage Regeneration Market is predicted to grow. It helps in understanding the key product segments and their future and helps make informed business decisions by having complete insights of the market by making in-depth analysis of market segments.

TABLE OF CONTENT:

1 Report Summary

2 Global Growth Trends Of the Stem Cell Cartilage Regeneration Market.

3 Market Share of Key Players around the world.

4 Breakdown Data by Type and its Application.

5 North America

6 Europe

7 Asia

8 Southeast Asia

9 Australia

10 India

11 Rest of World

12 International Players Profiles

13 Market Forecasts 2019-2029

14 Analysts Conclusions

15 Appendixes

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Stem Cell Cartilage Regeneration Market : Revenue, Growth, Business Outlook & Forecast 2020-2029 - PharmiWeb.com

Global Tissue and Organ Transplantation Market to Surpass US$ 25.6 Billion by 2027, Says Coherent Market Insights (CMI) – Business Wire

SEATTLE--(BUSINESS WIRE)--According to Coherent Market Insights, the global tissue and organ transplantation market is estimated to be valued at US$ 13.9 Billion in 2020 and is expected to exhibit a CAGR of 9.1% during the forecast period (2020-2027).

Key Trends and Analysis of the Global Tissue and Organ Transplantation Market:

The global tissue and organ transplantation market is expected to witness significant growth, owing to increasing R&D activities in tissue transplantation. For instance, in May 2019, researchers from AMALNA Consulting and RMIT University, in collaboration with Tithon Biotech Inc., predicted the characteristic frequencies related to parathyroid hormone activities, particularly differentiation of stem cells into osteoblasts. The research findings can aid in development of improved techniques for differentiation of stem cells in tissue transplantation and repair.

Similarly, in December 2018, the study Pathological Process of Prompt Connection between Host and Donor Tissue Vasculature Causing Rapid Perfusion of the Engineered Donor Tissue after Transplantation, published in the journal MDPI International Journal of Molecular Sciences, found that donor myocardial cell sheets including endothelial cell networks and potent pericytes could connect to host vasculature causing rapid donor tissue perfusion within 24 hours after transplantation.

Manufacturers are focusing on new product development, mergers & acquisition, and collaborations to expand their current product portfolio and strengthen their market position. For instance, in September 2016, Stryker Corporation acquired Instratek, a leading manufacturer of minimally invasive soft tissue recession instruments for ankle, foot, and upper extremity procedures.

For instance, in September 2015, Arthrex, Inc. launched ArthroFlex Acellular Dermal Matrix, which provides high strength and support to restore stability in capsular reconstruction.

Buy-Now this Research Report @ https://www.coherentmarketinsights.com/insight/buy-now/4342

Key Market Takeaways:

The global tissue and organ transplantation market is expected to exhibit a CAGR of 9.1% during the forecast period (2020-2027), owing to the governments and NGOs taking initiatives to encourage people to donate organs. For instance, in April 2020, Human Resource & Services Administration launched Hospital Organ Donor Campaign in the U.S.

North America is expected to be the most lucrative region in the tissue and organ transplantation market due to the rising number of transplants in the U.S. For instance, according to the health resources and service administration, in 2019, a total of 39,718 transplants were performed in the U.S.

Competitive Landscape:

Key players operating in the global tissue and organ transplantation market include CryoLife, Inc., Folio Biosciences, Arthrex, Abbvie, Inc., Zimmer Biomet, Medtronic PLC, Novartis AG, Stryker Corporation, BiolifeSolutions, Inc. , Teva Pharmaceuticals, and Veloxis Pharmaceutical.

Request Sample Copy of this Report @ https://www.coherentmarketinsights.com/insight/request-sample/4342

Market Segmentation:

Related Market Intelligence Report:

Organ Transplant Immunosuppressant Drugs Market, by Drugs Class (Calcineurin Inhibitors, Antiproliferative Agents, mTOR inhibitor (Mammalian Target of Rapamycin), Steroids, and Immunosuppressant Antibodies ), by Therapeutic Organ Transplant Type (Heart Transplant, Kidney Transplant, Liver Transplant, Lung Transplant, Pancreas Transplant, and Others), by Distribution Channel (Hospitals, Retail Pharmacies, and Online Pharmacies), and by Region (North America, Europe, Asia Pacific, Latin America, Middle East, and Africa) - Size, Share, Outlook, and Opportunity Analysis, 2018 2026

Read more: https://www.coherentmarketinsights.com/ongoing-insight/organ-transplant-immunosuppressant-drugs-market-2495

About Us:

Coherent Market Insights is a global market intelligence and consulting organization focused on assisting our plethora of clients achieve transformational growth by helping them make critical business decisions. We are headquartered in India, having sales office at global financial capital in the U.S. and sales consultants in United Kingdom and Japan. Our client base includes players from across various business verticals in over 57 countries worldwide.

Website: https://www.coherentmarketinsights.com

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Global Tissue and Organ Transplantation Market to Surpass US$ 25.6 Billion by 2027, Says Coherent Market Insights (CMI) - Business Wire

Lonza’s Cocoon will soon make dozens of stem cell therapies all at once – Innovation Origins

The name Lonza comes from the river in Switzerland near where the company was originally founded more than a hundred years ago, As such, it has nothing to do with the biomedical products and services that Lonza provides.

Lonza is active around the world and has around 15,000 employees with branches in the Netherlands as well. Such as the one on the Brightlands Chemelot Campus in Geleen. where approximately 250 people work there. This company division started as a start-up in Maastricht in 2005 and developed a production facility for stem cell and gene therapy to combat diseases. It became part of Lonza in 2018.

The reason that Lonza is on the Chemelot campus is due to its strategic location. This is very convenient for having access to all kinds of industry-related services that are already available there, says Willem Dullaers. He is the senior manager of quality control at Lonza in Geleen. Security is well organized, and we use a number of other facilities so that as a company you dont need to arrange these yourself.

The interesting thing about the Lonza production facility in Geleen is that the company isolates living cells and is even able to manipulate them on behalf of pharmaceutical groups. These companies then supply them to hospitals for the treatment of patients, primarily those suffering from forms of cancer. So what does Lonza do exactly and what does it ultimately deliver to those hospitals? is the question for Dullaers. This is not so easy to explain.

We work in cleanrooms at Lonzas premises in Geleen with the aim of selecting body cells from a sample of the patient taken in the hospital via a blood transfusion or bone marrow puncture. For example, body cells that are selected have the ability to fight cancer cells by virtue of their specific properties. If these cells are selected and reproduce in number after being cultured, it can be useful to add DNA to them so that they are able to attack the cancer cells even more effectively. Modification is done using a piece of deactivated virus that is used as a vector to introduce DNA into the selected cells.

Once that process is completed, the number of cells, which is usually very small, is cultivated to a larger quantity so that after various quality checks and the preparation for transport (cooled or frozen) are carried out, the cells are introduced into the patient. It is very common that patients are successfully treated afterward, says Dullaers. He refers to a report that made the world news last year. An Italian two-year-old boy with a rare immune disease (HLH) who was initially given up by doctors, Alex Montresor, was cured after stem cell therapy.

About 30 people are currently working on the production process for cell and gene therapy to treat people, Dullaers adds. The tasks that the biomedical doctors have to perform take time and require careful attention. They have to enter the cleanroom themselves to put the cells through the process to be transformed into stem cell therapies. They have to wear protective, hermetically sealed suits under the strictest safety conditions. That is to safeguard their own safety but also to prevent any potential contamination of the cells. Patients for whom this therapy is intended are often severely debilitated. They are not allowed to get sick as a result of a bacterium or particulate matter that has entered the cultured cells. A check always takes place to make sure that the product is completely clean. If this is not the case, it must be remade as a last resort.

At the moment, Lonza is working on a method to fully automate the culture process of the cells in the cleanroom. A pilot is currently underway at the Sheba Medical Center in Israel. It has a test setup with a so-called cocoon. The cocoon looks like an egg-shaped module of white plastic that is about one meter long. Inside the egg there is a small factory that automates all operations, from cell selection to DNA insertion and preparation for transport and administration.

Over the coming years, this innovative culture method for cell and gene therapy must be approved through clinical trials and by medicinal regulatory agencies such as the U.S. FDA and the European EMA. Only then can this robotized method be applied on a large scale.

I hope it will be achievable within five to ten years, says Dullaers. That will change a lot in terms of affordability and supply options for cell and gene therapy. Because it is such a cumbersome treatment, the costs are high right now. The production also takes a lot of time. Depending on the complexity of the process, the duration varies from a few days to sometimes more than two months, Dullaers notes.

If the entire process can be robotized, fewer people will be needed to do the work. I think that whereas we now work with 150 people, you will be able to do it with 15. However, you will need a different set of employees: People with a software background and an understanding of the machinery.

You can simultaneously fill a room with dozens of cocoons where cell therapies are made. That means that productivity is bound to skyrocket. Consequently, it will also be possible to make more medication based on the cells of individual patients, which will also be cheaper since less staff is needed. The chance of making mistakes is smaller than with work that involves human hands, Dullaers points out.

Another alternative is for hospital laboratories to make the gene and cell therapies themselves. It is conceivable that they would like to have a cocoon in their own hospital that they can use to treat patients.

You can also read the earlier articles in this series here:

The Chinese and Americans are knocking on the Dutch town of Geleens door to test innovative chem tech

Xilloc: Requests from dozens of hospitals worldwide for 3D-printed implants

Dutch Arlanxeo: 85% less CO2 emissions thanks to rubber from sugar cane

Niaga: 100% recyclable mattresses, furniture and carpets have the future

See more here:
Lonza's Cocoon will soon make dozens of stem cell therapies all at once - Innovation Origins

Global Cell Therapy Market Report 2020: Market to Recover in 2023 – PRNewswire

DUBLIN, Dec. 31, 2020 /PRNewswire/ -- The "Cell Therapy Global Market Report 2020-30: COVID-19 Growth and Change" report has been added to ResearchAndMarkets.com's offering.

Cell Therapy Global Market Report 2020-30: COVID 19 Growth and Change provides the strategists, marketers and senior management with the critical information they need to assess the global cell therapy market.

Major players in the cell therapy market are Fibrocell Science Inc., JCR Pharmaceuticals Co. Ltd., PHARMICELL Co. Ltd., Osiris Therapeutics Inc., MEDIPOST, Vericel Corporation, Anterogen Co. Ltd., Kolon TissueGene Inc., Stemedica Cell Technologies Inc. and AlloCure.

The global cell therapy market is expected to decline from $7.31 billion in 2019 to $7.2 billion in 2020 at a compound annual growth rate (CAGR) of -1.54%. The decline is mainly due to the COVID-19 outbreak that has led to restrictive containment measures involving social distancing, remote working, and the closure of industries and other commercial activities resulting in operational challenges. The entire supply chain has been disrupted, impacting the market negatively. The market is then expected to recover and reach $10.0 billion in 2023 at a CAGR of 11.55%.

The cell therapy market consists of sales of cell therapy and related services. Cell therapy (CT) helps repair or replace damaged tissues and cells. A variety of cells are used for the treatment of diseases includes skeletal muscle stem cells, hematopoietic (blood-forming) stem cells (HSC), lymphocytes, mesenchymal stem cells, pancreatic islet cells, and dendritic cells.

North America was the largest region in the cell therapy market in 2019. Asia Pacific is expected to be the fastest-growing region in the forecast period.

The cell therapy market covered in this report is segmented by technique into stem cell therapy; cell vaccine; adoptive cell transfer (ACT); fibroblast cell therapy; chondrocyte cell therapy. It is also segmented by therapy type into allogeneic therapies; autologous therapies, by application into oncology; cardiovascular disease (CVD); orthopedic; wound healing; others.

In August 2019, Bayer AG, a Germany-based pharmaceutical and life sciences company, acquired BlueRock Therapeutics, an engineered cell therapy company, for $1 billion. Through this transaction, Bayer AG will acquire complete BlueRock Therapeutics' CELL+GENE platform, including a broad intellectual property portfolio and associated technology platform including proprietary iPSC technology, gene engineering, and cell differentiation capabilities. BlueRock Therapeutics is a US-based biotechnology company focused on developing engineered cell therapies in the fields of neurology, cardiology, and immunology, using a proprietary induced pluripotent stem cell (iPSC) platform.

The high cost of cell therapy hindered the growth of the cell therapy market. Cell therapies have become a common choice of treatment in recent years as people are looking for the newest treatment options. Although there is a huge increase in demand for cell therapies, they are still very costly to try. Basic joint injections can cost about $1,000 and, based on the condition, more specialized procedures can cost up to $ 100,000. In 2020, the average cost of stem cell therapy can range from $4000 - $8,000 in the USA. Therefore, the high cost of cell therapy restraints the growth of the cell therapy market.

Key players in the market are strategically partnering and collaborating to expand the product portfolio and geographical presence of the company. For instance, in April 2018, Eli Lilly, an American pharmaceutical company entered into a collaboration agreement with Sigilon Therapeutics, a biopharmaceutical company that focused on the discovery and development of living therapeutics to develop cell therapies for type 1 diabetes treatment by using the Afibromer technology platform. Similarly, in September 2018, CRISPR Therapeutics, a biotechnological company that develops transformative medicine using a gene-editing platform for serious diseases, and ViaCyte, a California-based regenerative medicine company, collaborated on the discovery, development, and commercialization of allogeneic stem cell therapy for diabetes treatment.

The rising prevalence of chronic diseases contributed to the growth of the cell therapy market. According to the US Centers for Disease Control and Prevention (CDC), chronic disease is a condition that lasts for one year or more and requires medical attention or limits daily activities or both and includes heart disease, cancer, diabetes, and Parkinson's disease. Stem cells can benefit the patients suffering from spinal cord injuries, type 1 diabetes, Parkinson's disease (PD), heart disease, cancer, and osteoarthritis.

According to Cancer Research UK, in 2018, 17 million cancer cases were added to the existing list, and according to the International Diabetes Federation, in 2019, 463 million were living with diabetes. According to the Parkinson's Foundation, every year, 60,000 Americans are diagnosed with PD, and more than 10 million people are living with PD worldwide. The growing prevalence of chronic diseases increased the demand for cell therapies and contributed to the growth of the market.

Key Topics Covered:

1. Executive Summary

2. Cell Therapy Market Characteristics

3. Cell Therapy Market Size And Growth 3.1. Global Cell Therapy Historic Market, 2015 - 2019, $ Billion 3.1.1. Drivers Of The Market 3.1.2. Restraints On The Market 3.2. Global Cell Therapy Forecast Market, 2019 - 2023F, 2025F, 2030F, $ Billion 3.2.1. Drivers Of The Market 3.2.2. Restraints On the Market

4. Cell Therapy Market Segmentation 4.1. Global Cell Therapy Market, Segmentation By Technique, Historic and Forecast, 2015-2019, 2023F, 2025F, 2030F, $ Billion

4.2. Global Cell Therapy Market, Segmentation By Therapy Type, Historic and Forecast, 2015-2019, 2023F, 2025F, 2030F, $ Billion

4.3. Global Cell Therapy Market, Segmentation By Application, Historic and Forecast, 2015-2019, 2023F, 2025F, 2030F, $ Billion

5. Cell Therapy Market Regional And Country Analysis 5.1. Global Cell Therapy Market, Split By Region, Historic and Forecast, 2015-2019, 2023F, 2025F, 2030F, $ Billion 5.2. Global Cell Therapy Market, Split By Country, Historic and Forecast, 2015-2019, 2023F, 2025F, 2030F, $ Billion

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/rblnmb

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Research and Markets Laura Wood, Senior Manager [emailprotected]

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Global Cell Therapy Market Report 2020: Market to Recover in 2023 - PRNewswire

Induced Pluripotent Stem Cell Derived Human Lung Organoids to Map and Treat the SARS-CoV2 Infections In Vitro – DocWire News

This article was originally published here

Adv Exp Med Biol. 2021 Jan 1. doi: 10.1007/5584_2020_613. Online ahead of print.

ABSTRACT

COVID-19 is the current day pandemic that has claimed around 1,054,604 lives globally till date. Moreover, the number of deaths is going to increase over the next few months until the pandemic comes to an end, and a second wave has also been reported in few countries. Most interestingly, the death rate among certain populations from the same COVID-19 infection is highly variable. For instance, the European populations show a very high death rate, in contrast to the populations from Chinese ethnicities. Amongst all the closed cases with an outcome (total recovered + total died), the death rate in Italy is 13%, Iran is 6%, China is 5%, Brazil is 3%, The United States of America is 2%, India 2%, Israel is 1% as of October 08, 2020. However, the percentage was higher during the early phase of the pandemic. Moreover, the global death rate amongst all the patients with an outcome is 4%. Here we have reviewed virus-transmitted various respiratory tract infections and postulated a better understanding of SARS-CoV2 using lung stem cell organoids in vitro. Hence, here we propose the strategies of understanding first the infectivity/severity ratio of COVID-19 infections using various ethnicity originated induced pluripotent stem cell-derived lung stem cell organoids in vitro. The greater the infectivity to severity ratio, the better the disease outcome with the value of 1 being the worst disease outcome. This strategy will be useful for understanding the infectivity/severity ratio of virus induced respiratory tract infections for a possible betterment of community-based disease management. Also, such a strategy will be useful for screening the effect of various antiviral drugs/repurposed drugs for their efficacy in vitro.

PMID:33385178 | DOI:10.1007/5584_2020_613

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Induced Pluripotent Stem Cell Derived Human Lung Organoids to Map and Treat the SARS-CoV2 Infections In Vitro - DocWire News

Creative Medical Technology Holdings Announces Patent filing based on Preclinical Data in Model of Heart Attack using ImmCelz Regenerative…

PHOENIX, Dec. 31, 2020 /PRNewswire/ --(OTC CELZ) Creative Medical Technology Holdings Inc. announced today positive preclinical data using ImmCelz in treatment of a model of heart attack.

Patent application #63/132472, entitled "Treatment of Heart Failure and/or Post Infarct Pathological Remodeling by Ex Vivo Reprogrammed Immune Cells" covers data in which mice with restricted blood flow to the heart had significantly improved survival when treated with ImmCelz as compared to control mice.

"The role of the immune system in numerous aspects of regenerative medicine can not be overstated." Said Dr. Amit Patel, Board Member of the Company and co-inventor of the patent. "The data described today, while preliminary, supports the belief that ImmCelz, which is a "regenerative immunotherapy" can be applied across a broad range of conditions."

The ImmCelz product, based on decades of immunological research by Drs Thomas Ichim and Amit Patel, involves extraction of patient immune cells, "training" the immune cells to exhibit regenerative properties by incubation with regenerative cells outside of the body, followed by re-infusion of the patient's own cells. To date the Company has demonstrated that ImmCelz has therapeutic activity in stroke and liver failure.

"It is my honor that the work we initiated more than a decade ago is coming to fruition." Said Thomas Ichim, Ph.D, coinventor of the patent. "Ten years ago, Dr. Patel, myself and a team of colleagues described the potent synergies that occur when various cell types are utilized in combination for treatment of heart failure1. ImmCelz is the product of all these years of working and perfecting multi-cellular approaches to regenerative medicine."

"As we round out 2020, we have significantly expanded our Intellectual Property portfolio based on many years of collaborative research and development. Utilizing the ImmCelz technology for the treatment of heart failure is an excellent addition to this robust patent portfolio as it effects millions of patients in the U.S. alone. Patients with end stage heart failure in many cases have no options but heart transplantation, which is extremely limited." Said Timothy Warbington, President and CEO of the Company. "We are excited with the progress that the Company is making in advancing ImmCelz, which approaches regenerative medicine from a completely unique perspective. Given that the active cells in ImmCelz are derived from the same patient, we anticipate an accelerated path to FDA Investigational New Drug (IND) clearance."

"We encourage industry colleagues and other interested parties to review our early priority date patent filings to learn more about the ImmCelz technology and how it applies to multiple indications" Mr. Warbington further said.

About Creative Medical Technology Holdings

Creative Medical Technology Holdings, Inc. is a commercial stage biotechnology company specializing in stem cell technology in the fields of urology, neurology and orthopedics and trades on the OTC under the ticker symbol CELZ. For further information about the company, please visitwww.creativemedicaltechnology.com.

Forward Looking Statements

OTC Markets has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This news release may contain forward-looking statements including but not limited to comments regarding the timing and content of upcoming clinical trials and laboratory results, marketing efforts, funding, etc. Forward-looking statements address future events and conditions and, therefore, involve inherent risks and uncertainties. Actual results may differ materially from those currently anticipated in such statements. See the periodic and other reports filed by Creative Medical Technology Holdings, Inc. with the Securities and Exchange Commission and available on the Commission's website atwww.sec.gov.

Creativemedicaltechnology.com http://www.StemSpine.com http://www.Caverstem.com http://www.Femcelz.com

1 Ichim et al. Combination stem cell therapy for heart failure. Int Arch Med. 2010; 3: 5. Combination stem cell therapy for heart failure (nih.gov)

SOURCE Creative Medical Technology Holdings, Inc.

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Creative Medical Technology Holdings Announces Patent filing based on Preclinical Data in Model of Heart Attack using ImmCelz Regenerative...

Haywards Heath carer trying to raise funds for MS treatment – The Argus

A FORMER NHS care assistant is hoping the new year will see her raise 40,000 to fund groundbreaking treatment.

Joceline Colvert, 41, from Haywards Heath was diagnosed with multiple sclerosis (MS) at the age of 22.

During the last few years her condition has deteriorated and forced her to give up her job as a nursing assistant.

Haematopoietic stem cell transplantation, or HSCT, is available on the NHS but because Jocelines diagnosis was more than 15 years ago, she does not qualify for NHS treatment.

It means she has to fund treatment outside the UK.

READ MORE:'My MS relapse left me unable to walk or smile' - chef reveals devastating impact

She has raised 27,000 for the procedure at a specialist clinic in Russia, due to start in March next year.

The treatment involves removing the patients stem cells, followed by chemotherapy and then re-introducing the cleansed stem cells, effectively erasing the bodys memory of MS.

Joceline said: I am so excited about the difference the treatment could make to my life.

I bought my first wheelchair this year and decided I had to do everything to stop my mobility deteriorating any further.

I was devastated I didnt qualify for treatment on the NHS but rather than become despondent Ive put my energy into funding the treatment independently.

People have been so generous and I cant thank family, friends and complete strangers enough for their help so far.

Im hoping that I can reach the fundraising target so I can make the trip to Moscow.

Joceline Colvert hopes to halt the progress of her MS

The treatment has an 80 to 90 per cent success rate.

HSCT is not expected to cure MS, however in most cases it freezes it and stops it getting any worse and most patients see their mobility improve.

Joceline said: For years I have been dreading the future but for the first time I am excited about it and hopeful that I will be able to walk unaided again.

My dream is to be able to take my ageing dog for a proper walk in the future.

READ MORE:Mother refuses to be 'beaten' by MS after losing her son and husband

Although my husband takes her out, one of the hardest things is not being able to enjoy time outside with her.

The donations to Jocelines Gofundme page have reached two thirds of 40,000 needed to fund the treatment.

If you would like to donate and help Joceline make it to Russia, visit Jocelines GoFundMe page https://gf.me/u/y538k2

Original post:
Haywards Heath carer trying to raise funds for MS treatment - The Argus

Chronic graft-versus-host disease in children and adolescents with thalassemia after hematopoietic stem cell transplantation – DocWire News

This article was originally published here

Int J Hematol. 2021 Jan 1. doi: 10.1007/s12185-020-03055-w. Online ahead of print.

ABSTRACT

Data on chronic graft-versus-host disease (cGVHD) in patients with thalassemia after hematopoietic stem cell transplantation (HSCT) have not been specifically explored. The present study aimed to determine the incidence and clinical manifestations of cGVHD in children and adolescents with thalassemia who underwent HSCT and to compare healthcare utilization and medical cost between patients with and without cGVHD. We retrospectively analyzed the presentations, treatments, and outcomes of historical cGVHD (Seattle criteria), post-transplant admissions and direct medical cost for HSCT patients (n = 66). We used the 2014 NIH consensus criteria to reclassify the diagnosis of cGVHD (NIH cGVHD). Among 28 historical cGVHD patients, 13 (46.4%) fulfilled the NIH criteria. Reasons why the NIH criteria were unmet were reclassification as late acute GVHD and presence of distinctive signs without confirmatory tests. At 2 years after HSCT, the cumulative incidence of NIH cGVHD was 21.67% (95% CI, 12.31-32.74%). Lung cGVHD was associated with inferior survival with a hazard ratio of 13.6 (95% CI, 1.42-131.48). Patients with historical cGVHD had significantly increased frequency of inpatient admissions and medical cost. In conclusion, cGVHD was common in children with thalassemia receiving HSCT. Patients with cGVHD required prolonged immunosuppressive treatment and incurred high medical expenses.

PMID:33385291 | DOI:10.1007/s12185-020-03055-w

Originally posted here:
Chronic graft-versus-host disease in children and adolescents with thalassemia after hematopoietic stem cell transplantation - DocWire News

COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes – DocWire News

This article was originally published here

Hematol Oncol Stem Cell Ther. 2020 Dec 24:S1658-3876(20)30180-1. doi: 10.1016/j.hemonc.2020.12.001. Online ahead of print.

ABSTRACT

BACKGROUND: Cancer patients, particularly those on active anticancer treatment, are reportedly at a high risk of severe coronavirus disease 2019 (COVID-19) infection and death. This study aimed to describe the clinical characteristics and outcomes of patients diagnosed with COVID-19 whilst on anticancer treatment in a developing country.

METHODS: This is a retrospective observational study of all adult cancer patients at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Pakistan, from March 15, 2020 to July 10, 2020, diagnosed with COVID-19 within 4 weeks of receiving anticancer treatment, where a purposive sampling was performed. Cancer patients who did not receive anticancer treatment and clinical or radiological diagnosis of COVID-19 without a positive reverse transcription-polymerase chain reaction (RT-PCR) test were excluded. The primary endpoint was all-cause mortality after 30 days of COVID-19 test. Data was analyzed with SPSS version 23 (SPSS Inc., Chicago, IL, USA). Categorical parameters were computed using chi-square test, keeping p value < 0.05 as significant.

RESULTS: A total of 201 cancer patients with COVID-19 were analyzed. The median age of patients was 45 (18-78) years. Mild symptoms were present in 162 (80.6%) patients, whereas severe symptoms were present in 39 (19.4%) patients. The risk of death was statistically significant (p < .05) amongst patients with age greater than 50 years, metastatic disease, and ongoing palliative anticancer treatment. Anticancer treatment (chemotherapy, radiotherapy, hormonal therapy, targeted therapy, and surgery) received within preceding 4 weeks had no statistically significant (p > .05) impact on mortality.

CONCLUSIONS: In cancer patients with COVID-19, mortality appears to be principally driven by age, advanced stage of the disease, and palliative intent of cancer treatment. We did not identify evidence that cancer patients on chemotherapy are at significant risk of mortality from COVID-19 correlating to those not on chemotherapy.

PMID:33387453 | DOI:10.1016/j.hemonc.2020.12.001

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COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes - DocWire News

Cell Therapy Market 2020-2026 by Growth, Demand and Upcoming Business Opportunities – Farming Sector

The latest Cell Therapy Market report considers size, application segment, type, regional outlook, market demand, latest trends, as well as Cell Therapy Market share and revenue by manufacturers, the main company profiles, and forecasts of future growth potential. Analyses the current size of the market and its evolution in this sector over the coming years.

The report offers a critical hypothesis that identifies with the Cell Therapy Market by studying its breakdown. The global market with respect to Cell Therapy Market size, market share, growth factor, major supplier, revenue, product demand, sales size, quantity, cost structure, and new development in the Cell Therapy Market. The report also includes data on models and improvements, along with target industries and materials, limitations, and advancements. The formulation of this Cell Therapy Market research report has adopted the highest level of mind, practical solutions, dedicated research and analysis, innovation, integrated approaches, and advanced technology, among others. The insightful research report on the Cell Therapy Market includes Porters five forces analysis and SWOT analysis to understand the factors that influence the behavior of consumers and vendors.

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Cell Therapy Market: Competitive Landscape

The competitive landscape of a market explains strategies incorporated by key players of the market. Key developments and shifts in management in recent years by players have been explained through company profiling. This helps readers to understand the trends that will accelerate the growth of the market. It also includes investment strategies, marketing strategies, and product development plans adopted by major players in the market. The market forecast will help readers make better investments.

Impact of Covid-19 in Cell Therapy Market: The utility-owned segment is mainly being driven by increasing financial incentives and regulatory supports from the governments globally. The current utility-owned Cell Therapy Market are affected primarily by the COVID-19 pandemic. Most of the projects in China, the US, Germany, and South Korea are delayed, and the companies are facing short-term operational issues due to supply chain constraints and lack of site access due to the COVID-19 outbreak. Asia-Pacific is anticipated to get highly affected by the spread of the COVID-19 due to the effect of the pandemic in China, Japan, and India.

Key Players Profiled in the Report on the Cell Therapy Market

JCR Pharmaceuticals Co., Ltd., Kolon TissueGene, Inc.; and Medipost and many more.

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Cell Therapy Market Regional Analysis Includes:

1. Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia) 2. Europe (Turkey, Germany, Russia UK, Italy, France, etc.) 3. North America (the United States, Mexico, and Canada.) 4. South America (Brazil etc.) 5. The Middle East and Africa (GCC Countries and Egypt.)

Cell Therapy Market: Segment Analysis

This section of the report includes segmentation such as application, product type, and end-user. These segmentations aid in determining parts of the market that will progress more than others. The segmentation analysis provides information about the key elements that are thriving the specific segments better than others. It helps readers to understand strategies to make sound investments. The global Cell Therapy market is segmented on the basis of product type, applications, and its end users.

Cell Therapy Market Segment by Type:

By Use & Type Outlook, (Clinical-use,By Cell Therapy Type,,Non-stem Cell Therapies,Stem Cell Therapies,BM, Blood, & Umbilical Cord-derived Stem Cells,Adipose derived cells,Others), By Therapeutic Area, (Malignancies,Muscoskeletal Disorders,Autoimmune Disorders,Dermatology,Others,Research-use), By Therapy Type, (Allogenic Therapies,Autologous Therapies)

Key Highlights of the Table of Contents:

1. Cell Therapy Market Study Coverage: It includes key market segments, key manufacturers covered, the scope of products offered in the years considered, Cell Therapy Market and study objectives. Additionally, it touches the segmentation study provided in the report on the basis of the type of product and applications.

2. Cell Therapy Market Executive summary: This section emphasizes the key studies, market growth rate, competitive landscape, market drivers, trends, and issues in addition to the macroscopic indicators.

3. Cell Therapy Market Production by Region: The report delivers data related to import and export, revenue, production, and key players of all regional markets studied are covered in this section.

4. Cell Therapy Market Profile of Manufacturers: Analysis of each market player profiled is detailed in this section. This segment also provides SWOT analysis, products, production, value, capacity, and other vital factors of the individual player.

Further Key Aspects Of The Report Indicate That:

Chapter 1: Market Definition and Segment by Type, End-Use & Major Regions Market Size Chapter 2: Global Production & Consumption Market by Type and End-Use Chapter 3: Europe Production & Consumption Market by Type and End-Use Chapter 4: America Production & Consumption Market by Type and End-Use Chapter 5: Asia Production & Consumption Market by Type and End-Use Chapter 6: Oceania Production & Consumption Market by Type and End-Use Chapter 7: Africa Production & Consumption Market by Type and End-Use Chapter 8: Global Market Forecast by Type, End-Use and Region Chapter 9: Company information, Sales, Cost, Margin, news etc. Chapter 10: Market Competition by Companies and Market Concentration Ratio Chapter 11: Market Impact by Coronavirus. Chapter 12: Industry Summary

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Cell Therapy Market 2020-2026 by Growth, Demand and Upcoming Business Opportunities - Farming Sector