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4D hires a trio of area heads as it ramps up its gene therapy pipeline – FierceBiotech

4D Molecular Therapeutics raised $75 million in June to get several gene therapy programs into and through the clinic. Now, its adding a trio of executives to spearhead its work in heart, eye and lung diseases as it looks to shepherd treatments in those focus areas forward.

Robert Fishman, M.D. becomes 4Ds chief medical officer and therapeutic area head for pulmonology. He joins from Xoc Pharmaceuticals, where as chief medical officer he led phase 1 development for programs in Parkinsons disease and migraine. Before that, he headed clinical development at InterMune, overseeing the pivotal trial of Esbriet, an idiopathic pulmonary fibrosis drug now marketed by Roche.

GenScript ProBio is the bio-pharmaceutical CDMO segment of the worlds leading biotech company GenScript, proactively providing end-to-end service from drug discovery to commercialization with professional solutions and efficient processes to accelerate drug development for customers.

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Raphael Schiffmann, M.D., signs on as senior vice president and therapeutic area head for 4Ds cardiology stable. He was previously director of the Institute of Metabolic Disease at the Baylor Research Institute and the lead investigator of the developmental and metabolic neurology branch at the NIHs National Institute of Neurological Disorders and Stroke.

Robert Kim, M.D., joins 4D as a senior vice president and clinical therapeutic area head of ophthalmology. Hes held multiple chief medical officer roles at ViewPoint Therapeutics, Apellis Pharma and Vision Medicines, and earlier in his career worked in ophthalmology at GlaxoSmithKline, Genentech and Novartis.

The three executives arrive six months after 4D topped up its coffers with a $75 million series C round. The capital, which came two years after a $90 million B round, was earmarked to push three programs into the clinic, including two that are partnered with Roche.

Those programs include 4D-310, a treatment for Fabry disease in which patients cells accumulate a type of fat called globotriaosylceramide, and 4D-125, a treatment for the eye disease X-linked retinitis pigmentosa. Roche has the exclusive right to develop and commercialize the latter. Roche has licensed the third prospect, 4D-110, a treatment for a type of vision loss called choroideremia.

RELATED: 4D raises $90M to move gene therapies into clinical testing with AstraZeneca and Roche

The funds will also bankroll the development of 4Ds preclinical pipeline, including IND-enabling studies for 4D-710, a program in cystic fibrosis, and other candidates for neuromuscular diseases and ophthalmology.

With the addition of Robert Fishman, Raphael Schiffmann and Robert Kim to our clinical R&D leadership team, 4DMT gains not only extensive experience in clinical development and translational medicine, but also unique and specific experience within each of the initial 4DMT therapeutic areas," said 4D CEO David Kim, M.D., in a statement.

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4D hires a trio of area heads as it ramps up its gene therapy pipeline - FierceBiotech

Nobel Prize history from the year you were born – Herald & Review

Nobel Prize history from the year you were born

Since 1901, Nobel Prizes have honored the worlds best and brightest and showcased the work of brilliant and creative minds, thanks to Swedish businessman Alfred Nobel, who made his fortune with the invention of dynamite.

The Prize in Physiology or Medicine often honors those whose discoveries led to medical breakthroughs, new drug treatments, or a better understanding of the human body that benefit us all.

The Prize in Literature celebrates those skilled in telling stories, creating poetry, and translating the human experience into words. The Prizes in Chemistry and Physics remind most of us how little we understand of genetics, atomic structures, or the universe around us, celebrating the scientists who further knowledge. A later addition to the award roster, the Nobel Memorial Prize in Economic Sciences is not an original Prize, but was established by the Central Bank of Sweden in 1968 as a memorial to Alfred Nobel. It applauds those who can unravel the mysteries of markets, trade, and money.

The Peace Prize celebrates, in Nobels words, the person who shall have done the most or the best work for fraternity between nations, the abolition or reduction of standing armies and for the holding and promotion of peace congresses, sometimes risking their lives to do so.

So precious are the awards that the medals of German physicists Max von Laue and James Franck, stored away for safekeeping in Copenhagen during World War II, were dissolved in acid to keep them away from approaching Nazi troops. After the war, the gold was reconstituted from the acid and recast into new medals.

But Nobel history has not been entirely noble. In 1939, British Prime Minister Neville Chamberlain, known for his policy of appeasement toward Nazi Germany, was nominated for the Peace Prize. In an act of irony and protest, members of the Swedish Parliament nominated Adolf Hitler. That nomination was withdrawn. Some recipients have ordered oppressive crackdowns on their own people or ignored genocides, either before or after receiving the Prize. The 1918 Nobel Prize in Chemistry was given to Germanys Fritz Haber, who invented a method of producing ammonia on a large scale, which was helpful in making fertilizer. But the same chemist helped develop the chlorine gas that was used as a chemical weapon in World War I.

Stacker looked at facts and events related to the Nobel Prizes each year from 1931 to 2020, drawing from the Nobel Committees recollections and announcements, news stories, and historical accounts.

Take a look, and see what was happening with the Nobel Prizes the year you were born.

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Erik Axel Karlfeldt was the first Nobel winner to be awarded posthumously. The Swedish poet was alive during the nomination and deliberation process but died six months before the Literature Prize was announced. As of 1974, the rules were changed so that awards can only be given posthumously if the winner dies after the announcement but before the formal award is bestowed.

John Galsworthy, author of The Forsyte Saga, was awarded the Nobel Prize in Literature. The chronicle of English life became a hugely popular miniseries in 1967 on American public television.

Ivan Bunin, the first Russian writer to win the Nobel Prize in Literature, departed Russia after the 1917 revolution and settled in France as a permanent exile. His books were banned by Soviet authorities due to his anti-Bolshevik writing. To accept his Nobel Prize in Stockholm, Bunin had to travel through Germany, where he was arrested by the Nazis and falsely accused of smuggling jewels. The Nazis forced him to drink a bottle of castor oil before letting him go.

Three Americans shared the Nobel Prize in Physiology or Medicine for their research into anemia, when the bodys red blood cell count is low. George Whipple found dogs formed new blood cells by eating diets of liver, kidney, meat, and apricots, and George Minot and William Murphy applied those findings to humans with pernicious anemia. They also delved into the cause of pernicious anemia: a shortage of vitamin B12.

The 1935 Peace Prize was awarded to Carl von Ossietzky, a journalist and critic of Nazi Germany who was being held in a concentration camp. Hitler would not allow him to accept the prize. He died in 1938 in a prison hospital. Also in 1935, married couple Frdric Joliot and Irne Joliot-Curie won the Nobel Prize in Chemistry. Joliot-Curie was the daughter of Marie Curie and Pierre Curie, also Nobel Prize winners.

The Norwegian royal family chose not to attend the Nobel ceremony following the controversial choice of German pacifist Carl von Ossietzky to win the Peace Prize. Critics said the prize decision would provoke Germany. The royal family offered no official explanation for skipping the ceremony, but it was widely believed that Norway wanted to distance itself from the prize selection.

American physicist Clinton Davisson won the Nobel Prize partly by accident. When he was testing the hypothetical relation between particle velocity and wavelength, he bombarded a nickel block with electrons and measured how they scattered. But when the nickel was baked at high heat after accidental contamination, the structure of its atoms changed, as did the patterns of the electrons, proving the hypothesis.

No Nobel prizes were awarded in 1940 due to World War II. Norway was occupied by German forces, and Adolf Hitler was angry about the 1936 Peace Prize awarded to Carl von Ossietzky, a journalist who disclosed that Germany had been secretly rearming, a violation of the Treaty of Versailles that ended World War I. Ossietzky was tried and convicted of treason.

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Not only were no Nobel Prizes awarded while the world was locked in war, but a significant brain drain was underway that would see Europe lose many of its brilliant thinkers. By 1941, a dozen Nobel-winning scientists had left for England and the United States, including physicists Niels Bohr, a winner in 1922, Albert Einstein, who won in 1921, and Enrico Fermi, who won in 1938.

Ralph Bunche was principal secretary of the United Nations Palestine Commission when he was awarded the Peace Prize for his role in mediating the 1949 cease-fires between Israel and Arab states after the partition of Palestine. Bunche, an academic and U.S. State Department advisor, was the first Black person to receive a Nobel Prize.

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The Nobel Memorial Prize in Economic Sciences was established in 1968 by Sveriges Riksbank, the central bank of Sweden. It was created to mark the banks 300th anniversary. The first recipients would be awarded in 1969.

The first Nobel Memorial Prize in Economic Sciences was shared by Norwegian economist Ragnar Frisch and Dutch economist Jan Tinbergen, who helped develop the study of economics based upon mathematics. Tinbergen created a model of macroeconomics, placing economic variables in mathematical relationships to each other. His younger brother, Nikolaas Tinbergen, was one of three scientists awarded the 1973 Nobel Prize in Physiology or Medicine for their studies of animal behavior, particularly how animals communicate and care for their young.

Swedens Ulf von Euler discovered the bodys neurotransmitter norepinephrine, which is involved in the fight-or-flight process, and was awarded the Nobel Prize in Physiology or Medicine. His father, Hans von Euler-Chelpin, won the Nobel Prize in Chemistry in 1929 for his research in the fermentation of sugar and the enzymes involved in the process.

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Physicist Dennis Gabor won the Nobel Prize in Physics for inventing the holograph, and German Chancellor Willy Brandt won the Peace Prize for helping ease relations between East and West Germany. Under his administration, West Germany signed a nuclear weapons non-proliferation treaty, reached a nonviolence deal with the Soviet Union, and laid the groundwork for making family visits easier in the divided city of Berlin.

In awarding the Prize in Literature, the Nobel Committee honored German writer Heinrich Bll, saying his a broad perspective on his time and a sensitive skill in characterization has contributed to a renewal of German literature." After World War II, Bll was part of the Gruppe 47, a number of influential writers who would meet over the course of three decades as they dealt with the wars destruction and the aftermath of the Holocaust.

In a controversial decision, the 1973 Nobel Peace Prize was awarded jointly to U.S. Secretary of State Henry Kissinger and Le Duc Tho of North Vietnam for the Vietnam ceasefire negotiations. But the North Vietnamese leader refused to accept the prize, on grounds that the war was ongoing and the United States violated terms of the agreement. Kissinger did not travel to Norway to accept the prize and said he wanted to return it but was told he could not do so.

Costa Rican President Oscar Arias Snchez is credited for his leadership in encouraging five presidents in Central America to sign a peace agreement ending the regions civil wars. The peace plan signed by Costa Rica, Guatemala, El Salvador, Honduras, and Nicaragua called for human rights safeguards, free elections, and an end to interference by other countries.

The winners of the Prize in Physiology or Medicine brought relief to millions with their drug discoveries. The work of Sir James Black led to the use of receptor-blocking drugs to treat heart disease, hypertension, and peptic ulcers, and collaborators Gertrude Elion and George Hitchings made discoveries that led to drugs for the treatment of leukemia, malaria, gout, and herpes virus infections.

Myanmars human rights activist Aung San Suu Kyi was under house arrest when she was awarded the Peace Prize. In 2015 she was released and elected to national office, but she has come under strong criticism for her countrys treatment of its Muslim Rohingya minority and its possible genocide. Calls were made for her Nobel Prize to be revoked, but the head of the Nobel Foundation said it would not be withdrawn for events that took place after it was awarded.

South Africa took the spotlight when the Nobel Peace Prize was awarded to Nelson Mandela and Frederik Willem de Klerk for their roles in ending the apartheid system of racial separation. Mandela was imprisoned 27 years for his political activism, and de Klerk, the president of South Africa, released him in 1990. They went on to work together to end apartheid and design a new constitution that allowed universal voting rights, regardless of race.

American John Nash was one of three winners of the Nobel Memorial Prize in Economic Sciences for his work on game theory. Nashs struggle with schizophrenia was portrayed in the 2001 Academy Award-winning film A Beautiful Mind, starring Russell Crowe as the Princeton-educated mathematician. His work, which became known as the Nash equilibrium, is used in understanding the processes of chance and decision-making.

Joseph Rotblat, a physicist and longtime opponent of nuclear weapon development, won the Nobel Peace Prize 50 years after atom bombs were dropped on Hiroshima and Nagasaki. He withdrew in 1943 from the Manhattan Project, which was producing nuclear weapons. He worked with the anti-nuclear Pugwash movement, a series of conferences with which he shared the Peace Prize.

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Southeast Asias East Timor was highlighted when the Peace Prize was awarded to Carlos Belo and Jos Ramos-Horta. Ramos-Horta was a leader of resistance in East Timor to the occupation by Indonesia and helped build international support for self-determination, and Belo, a Roman Catholic bishop, demanded the United Nations and the United Nations Commission on Human Rights take notice. The Peace Prize is considered a major factor in East Timor achieving independence in 2002.

Citing the more than 100 million anti-personnel landmines estimated to be strewn around the world, the Nobel Committee gave the Peace Prize to the International Campaign to Ban Landmines and to its coordinator Jody Williams for their accomplishments in banning and clearing mines. Their work culminated in the United Nations Mine Ban Convention, adopted in 1997, that prohibited the stockpiling and use of landmines and required countries to clear mines.

Two political leadersDavid Trimble and John Humein Northern Ireland shared the Peace Prize for helping bring about the Good Friday Agreement that laid out plans for governance of Northern Ireland. Key to the agreement were the Protestant Ulster Unionist Party, led by Trimble, and the Catholic Social Democratic and Labour Party, led by Hume.

The Nobel Committee applauded Mdecins Sans Frontires, known as Doctors without Borders in English, for its extensive humanitarian work across several continents. It said the organization maintained a high degree of independence, helped build public opinion in opposition to humanitarian abuses, and helped forge contacts between sides in conflicts.

Understanding our relation to money earned the Nobel Prize for two American economists. James Heckman researched factors that affect statistical sampling, and his findings have been used to understand how early life experiences influence earnings potential and economic status. Daniel McFadden studied how people make decisions, developing so-called discrete choice models that can explain and predict behavior and are applied to such real-life uses as public transportation systems and senior housing.

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Americans George Akerlof, Michael Spence, and Joseph Stiglitz were awarded the Nobel Memorial Prize in Economics for their work on markets with asymmetric informationmarkets in which one side has better information than the other. Akerlof looked at the consequences of such markets in areas like developing world lending and medical insurance, Spence demonstrated how market participants convey information, and Stiglitz showed how asymmetric markets work in areas like unemployment and credit.

Jimmy Carter was commended for decades of untiring effort to find peaceful solutions to international conflicts, to advance democracy and human rights, and to promote economic and social development. The Committee cited his foreign policy achievements including the Panama Canal treaties, Camp David Middle Eastern accord, and SALT II treaty with the Soviet Union as well as his founding afterward of The Carter Center, which specialized in international conflict mediation and election monitoring.

The creators of magnetic resonance imagining, or MRI, took home the Nobel Prize in Physiology or Medicine. Paul Lauterbur of the United States and Britains Sir Peter Mansfield researched the behavior of atoms and molecules in a magnetic field to develop interior imagery of the human body.

Wangari Maathai, the first female professor in Kenya, became the first African woman to win the Nobel Peace Prize. Already active in the nations democratic movement, Maathai launched a grassroots movement that mobilized women to plant trees to fight deforestation. Called the Green Belt Movement, it spread elsewhere in Africa and led to the planting of more than 30 million trees.

Winners of the Nobel Prize in Physiology or Medicine, Australians J. Robin Warren and Barry Marshall discovered the bacterium that causes gastritis and peptic ulcer disease. Their discovery ran counter to the commonly held belief that peptic ulcer disease was caused by lifestyle and stress. The revelation influenced research into the causes of other chronic inflammatory conditions and the links between chronic infection, inflammation, and cancer.

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The winner of the Nobel Prize in Chemistry, American Roger Kornberg, researched the structure and role of an enzyme called RNA polymerase in a genetic process essential to building and maintaining molecular and cell structure. His father Arthur Kornberg won the 1959 Prize in Physiology or Medicine for his pioneering work in genetics.

Doris Lessing, author of dozens of books including the novel The Golden Notebook, became the oldest winner of the Nobel Prize in Literature at age 88. She told reporters from her doorstep in London that she was not that surprised because her name had been under consideration for decades. Either they were going to give it to me sometime before I popped off or not at all, she said.

The New York Times columnist Paul Krugman won the Nobel memorial Prize in Economic Sciences for his work in international trade patterns and economic geography. Krugman was instrumental in the development of New Trade Theory, which concerns factors in international market patterns such as economies of scale and the network effect, when goods become more valuable with wider use.

U.S. President Barack Obama was presented the Peace Prize during his first year in office. The Committee said it recognized Obama for his "extraordinary efforts to strengthen international diplomacy and cooperation between peoples. Critics questioned whether Obama, the countrys first Black president, had earned such a distinction so early in his term.

Chinas Liu Xiaobo was in prison when he was awarded the Nobel Peace Prize. The human rights activist had been jailed following the 1989 massacre at Tiananmen Square, imprisoned again for criticizing Chinese policies toward Taiwan and the Dalai Lama, and sentenced to prison again in 2009 for seeking political reform. He died in 2017.

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When the Nobel Prize in Physiology or Medicine was announced, the Foundation learned that one of the winners, Ralph Steinman, had died three days earlier of cancer. Although the rules say the awards are not given posthumously, it was decided that the Canadian immunologist should be a Nobel Laureate because the Nobel Assembly had announced the winners without knowing he was dead.

Sir John Gurdon of England and Shinya Yamanaka of Japan, winners of the Nobel Prize in Physiology or Medicine, researched the way cells and organisms develop. They discovered how mature specialized cells could be reprogrammed to become immature cells, a major medical breakthrough applicable to stem cell research.

The three American economists who shared the Nobel Prize made discoveries that help predict the long-term prices of stocks and bonds. Eugene Famas research was used in the development of stock index funds, Robert Shiller discovered certain dynamics about stock prices and dividends, and Lars Hansen looked at theories of risks and returns that are used in asset pricing.

At age 17, Malala Yousafzai was the youngest Nobel Laureate when she was awarded the 2014 Peace Prize. Yousafzai, an outspoken advocate for girls education and rights, survived an attempted assassination in 2012 by the Taliban in Pakistan. She shared the Peace Prize with Indian activist Kailash Satyarthi, who was honored for his work fighting child labor.

Jeffrey Hall, who shared the 2017 Nobel Prize in Physiology or Medicine for his work understanding the human body clock, had left science about a decade before winning his prize. He was outspoken about his frustration with what he saw as an inadequate, wasteful, and unfair research funding process.

At 96 years old, Arthur Ashkin became the oldest Nobel Laureate until he was surpassed by a 97-year-old winner the following year. Ashkin invented optical tweezers, sharp laser beams that can grab particles, atoms, molecules, and bacteria. The Nobel Prize in Literature was postponed due to scandal involving sexual misconduct, conflicts of interest, and financial malpractice at the Swedish Academy.

At 97, John Goodenough became the oldest Nobel Laureate when he won the Prize for Chemistry. His work led to the development of lithium-ion batteries, which had higher voltage than previous batteries, and are used to power mobile telephones and electric cars.

The three winners of the Prize in PhysicsBritains Roger Penrose, Germanys Reinhard Genzel, and Andrea Ghez of the United Stateswere honored for research into the existence and formation of black holes in the Milky Way. Penrose proved how the theory of relativity leads to the formation of black holes, while Genzel and Ghez discovered the role of a massive black hole at the center of the galaxy in affecting the orbits of stars.

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Germanys Adolf Butenandt won the Nobel Prize in Chemistry for his research into sex hormones that would be used in the development of oral contraception. Like Richard Kuhn in 1938, he was forced by the Nazis to decline the prize but was able to accept the certificate and medal in 1949. Germanys Gerhard Domagk, whose research led to the development of antibiotics, also had to turn down the Nobel Prize in Physiology or Medicine but got it after the war.

While no Nobel Prizes were awarded, 1942 was the year that the name United Nations was coined by President Franklin Roosevelt in a declaration by 26 nations to stand together against the Axis powers. Founded three years later, the United Nations, along with its agencies, programs, and staff, has been awarded the Nobel Peace Prize a dozen times. The U.N.s High Commissioner for Refugees (UNHCR) has won it twice, and most recently, the U.N.s World Food Programme won in 2020.

Henrik Dam and Edward Doisy shared the Nobel Prize in Physiology or Medicine for their work in the discovery of vitamin K, which the human body uses for clotting and healing. Dam determined that Vitamin K is needed for blood to coagulate, and Doisy found ways to produce it artificially, which was useful in stopping bleeding in small children.

The Nobel Peace Prize was awarded to the International Committee of the Red Cross for the work it had done during the war on behalf of humanity. It was the first Peace Prize bestowed in five years; the prizes were not given out from 1939, the year Germany invaded Poland at the start of World War II, to 1943.

Two American activists shared the Nobel Peace Prize. One was Emily Greene Balch, co-founder of the Womens International League for Peace and Freedom and a professor at Wellesley College for 22 years until she was fired for her activism. John Raleigh Mott, head of the Young Mens Christian Association, promoted international youth programs, worked with relief programs for prisoners of war, and was an outspoken critic of colonial oppression and race discrimination.

Gerty Cori, the first woman to win the Nobel Prize in Physiology or Medicine, was honored with her husband Carl Cori for their work in understanding the metabolism process. When the couple moved to America in 1922 from Austria, Carl Cori was hired as a biochemist at a New York research institute. Gerty Cori could only find work as an assistant pathologist, despite having the same degrees and research experience, because she was a woman. She was finally allowed a position equal with her talent and experience at Washington University in St. Louis in 1938.

Although the Nobel Prize in Literature is considered to honor a writers body of work, the Nobel Academy singled out The Old Man and the Sea when it chose American author Ernest Hemingway. It said the novel demonstrated his mastery of the art of narrative.

The winner of the Chemistry Prize, Vincent du Vigneaud, studied biochemical sulphur compounds, including oxytocin, a hormone involved in sexual intimacy and reproduction. Sometimes called the cuddle or love hormone, it is released when people bond, including as couples or parents with children. Vigneaud isolated oxytocin, calculated its chemical composition, and determined how to produce it artificially.

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The king of Sweden goodnaturedly reprimanded John Bardeen for leaving most of his family homehis children were in schoolwhen he was awarded the Nobel Prize in Physics. The American physicist told the king he would bring his family the next time. Sure enough, Bardeen won a second Nobel Prize in 1972, and he took his whole family to theceremony.

Biochemists Severo Ochoa and Arthur Kornbergs work on DNA and RNA earned them the Nobel Prize in Physiology or Medicine. Ochoa discovered how to create RNA, and Kornberg, formerly a student of Ochoas, found ways of making DNA. Kornbergs son, Roger, a chemical physicist, also conducted genetic research and won the Nobel Prize in Chemistry in 2006.

Winners of the Nobel Prize in Physiology or Medicine, Roger Guillemin and Andrew Schally used pig brains and lamb brains in their research on hormonal roles and structure. They shared the prize with Rosalyn Yalow, a nuclear physicist who developed radioimmunoassay, a method that can measure extremely small amounts of bodily substances. It was used in helping determine the cause of type 2 diabetes.

In awarding the Peace Prize to the International Physicians for the Prevention of Nuclear War, the Nobel Committee singled out its Soviet founder Yevgeny Chazov and American founder Bernard Lown to accept the award because of their cooperative influence. The IPPNW consists of tens of thousands of medical professionals, now in 64 countries, who banded together in hopes of preventing and averting nuclear war.

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Indian leader Mahatma Gandhi was nominated five times for the Nobel Peace Prize, the final time being in 1948 not long before he was assassinated. That year, the Nobel Committee chose not to bestow any award, declaring there was no suitable living candidate.

The winner of the Nobel Prize in Medicine, Portugals Egas Moniz, invented the lobotomy. He discovered how a surgical incision into the brains prefrontal lobe could alter behavior. Lobotomies were used widely to treat mental illness in the 1940s and 1950s until they were widely recognized as dangerous, and medication for mental illness became more commonly prescribed.

The awarding of the Peace Prize to Dag Hammarskjld, the second Secretary-General of the United Nations, was only the second time a Nobel was given posthumously. The first occasion was the posthumous literature prize awarded to Erik Axel Karlfeldt in 1931. The rules were changed in 1974 so that prizes could not be awarded posthumously unless the winner dies after the announcement but before the award ceremony.

The winner of the Nobel Prize in Physiology or Medicine, to American James Watson, would later sell it at auction at Christies in 2014 to raise money for charity. Russian tycoon Alisher Usmanov paid $4.7 million, then said he was returning the award to the scientist. Watson won for discovering the structure of DNA along with Francis Crick.

Free-market economist Friedrich von Hayek, a critic of central planning, shared the Nobel Prize with Swedish economist Gunnar Myrdal. Hayek argued for a decentralized market system with open competition and disagreed with the use of government fiscal policy to moderate movements of the economy as promoted by economist John Maynard Keynes.

American economist Milton Friedman was awarded the Nobel Memorial Prize in Economic Sciences for his work on monetarypolicy. Friedman advocated for free markets and opposed government economic intervention. His views influenced the conservative fiscal policies of U.S. President Ronald Reagan and British Prime Minister Margaret Thatcher. He was a major proponent of school vouchersusing public tax funds to pay for students to attend private schoolsa system that remains hugely controversial to this day.

Mother Teresa of the Missionaries of Charity was given the Nobel Peace Prize for her work assisting the poor in Kolkata, especially its orphans, lepers, and terminally ill. Pope Francis declared the Albanian nun a saint in 2016. She started the Missionaries of Charity with a dozen nuns and it had nearly 5,000 at the time of her death in 1997.

Marking the 500th anniversary of Christopher Columbus landing in the Americas, Mayan Rigoberta Mench Tum of Guatemala was hailed for her campaign for human and Indigenousrights. Taking a global approach, she facilitated the use of international intermediaries in negotiations between guerrilla forces and the government, culminating in a 1996 peace agreement that ended a 36-year civil war.

Max Theiler of South Africa was honored for his research on yellow fever, a deadly disease found in subtropical and tropical South America and Africa and spread primarily by mosquitoes. Theiler discovered how to transmit the yellow fever virus to mice, helping produce weaker forms of the virus that could be used as a vaccine for humans.

For his role in the discovery of streptomycin, Selman Waksman was awarded the Nobel Prize in Physiology or Medicine. Streptomycin was the first antibiotic found to be effective against tuberculosis. Waksman studied how the bacteria that causes tuberculosis interacted with microorganisms in soil and found that a bacterium called Streptomyces griseus blocked its growth.

British Prime Minister Winston Churchill won the Nobel Prize in Literature for his works that included an autobiography, several volumes about the First and Second World Wars, and his notable speeches during World War II. From 1946 to 1953, Churchill was nominated in seven years for the Literature Prize and twice for the Nobel Peace Prize.

Ending conflict in the Middle East was the focus of Canadian historian and diplomat Lester Pearson, who won the Peace Prize for his role in ending violence that erupted in 1956 over control of the Suez Canal. The conflict among the major superpowers could have had severe global consequences. Thanks to Pearsons efforts, a United Nations Emergency Force was dispatched to oversee a cease-fire.

Russias Boris Pasternak was awarded the Nobel Prize in Literature, which he at first accepted but later was forced to turn down by Soviet authorities who banned his novel Doctor Zhivago. The only novel the poet wrote, Dr. Zhivago was deemed to be anti-Soviet and remained forbidden until the late 1980s.

Frances Jean-Paul Sartre was awarded, and declined, the Nobel Prize in Literature.He explained that he always declined official honors and that as a writer, he felt he should remain distinct from any institution.

The United Nations Childrens Fund, better known as UNICEF, was awarded the Nobel Peace Prize. UNICEF started out in 1946 providing food, clothes, and medicine to children and mothers but expanded to promote nutrition, school attendance, and health care in developing countries. The Nobel Committee honored UNICEF for its effort to enhance solidarity between nations and reduce the difference between rich and poor states.

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Peyton Rous won the Nobel Prize in Physiology or Medicine when he was 87, the oldest winner ever in the category. The American studied the role of viruses in cancer cells and transmission. His work was based on research begun in the early 1910s.

Contributions to understanding how the human eye functions earned the Nobel Prize in Physiology or Medicine for a scientific trio. Finnish scientist Ragnar Granit researched the types of cones responsible for seeing color; American Keffer Hartline analyzed how the eye processes contrasts; and American George Wald studied the role of light in visual impressions.

Danish physicist Aage Bohr won the Nobel Prize for his experiments on the structure of atoms. His father, Niels Bohr, won the Nobel Prize in Physics in 1922, also for work on atomic structure. The elder Bohr created a theory that explained how moving electrons cause atoms to emit light.

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The Camp David Agreement, which laid out a framework for peace in the Middle East, earned the Nobel Peace Prize for Egyptian President Mohamed Anwar al-Sadat and Israeli Prime Minister Menachem Begin. U.S. President Jimmy Carter was to have been a third recipient, but a technicality prevented him from being nominated within the Committees deadline. But he won the Peace Prize nevertheless in 2002.

Alva Myrdal, along with Mexicican diplomat Alfonso Garca Robles, won the Nobel Peace Prize for working toward nuclear disarmament. Myrdal was a Swedish scientist, government official, and diplomat, and she was married to Gunnar Myrdal, a Swedish economist who was awarded an Economics Nobel in 1974.

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Nobel Prize history from the year you were born - Herald & Review

Accumulated genetic variations: What they are and why they matter to a complete health picture – MedCity News

Genes are by no means a crystal ball, but they can be used to forecast susceptibility to a variety of conditions, from cancers and heart disease to chronic inflammatory conditions. As such, they can help healthcare professionals and patients make better care decisions.

Generally speaking, whenpeople today think about genetic predispositions, theythink about their parents and family trees.However, those inherited genetic variationsbequeathed by ourparents and grandparents are only a portion ofacomplete genetic picture and often not the most revealing one.Thegenetic variationsmost commonly linked to disease are actually?not?the ones from your parents; rather, they areacquiredas one ages.

Mom and Dad Cant Take All the Heat forAll Health Challenges Unlike inheritedgenetic predispositions,accumulatedgenetic changes(otherwise known as somatic)are the result ofenvironmental influences, such as smoking, chemicals or ultra-violet radiation. They can also stem from common errorscells make as they duplicate themselves over time.The expansion of these detrimental variations cause damage to DNA within blood cells,aphenomenon known as clonal hematopoiesis (CH), whichincreases susceptibility to many diseases, including many types of cancer.

Germline variations in genes still indicate potential vulnerabilities, with one in five healthy adults estimated to carry an inherited marker. However, these genetic abnormalities represent a static metric. Once individuals are tested for inherited variations, they will never need to do so again. Whats more, many of the predispositions that surfaced through this testing can be addressed through lifestyle and medical interventions. It boils down to being aware of them.

Somatic changes, on the other hand, can happen at any stage of life. While many of these changes have no clinical ramifications, some of them can exacerbate predispositions inherited from our parents because the disease is often the result of multiple genetic variations banding together, inherited or acquired.

The chances of an acquired variation accumulating and accelerating within the body increase significantly as we age, generally after the age of 40 and growing each decade. This could drastically change a patients health profile, casting inherited vulnerabilities into a new light without any warning or symptoms.

Understanding Accumulated VariationsA growing body of research links somatic changes to an increased likelihood of blood cancers and cardiovascular disease, both heart disease and stroke. The same research reveals that these accumulated genetic variations contribute to infection and severe inflammatory reactions, some of which are associated with severe cases of Covid-19.

A study conducted byJAMA Cardiologyexplores theconnectionbetween accumulated genetic change anda pro-inflammatory immune response that resembles the exaggerated cytokine release syndrome (CRS)experienced by patients with severeCovid-19.Notably,the researchfoundthat patients who experienced the most extreme inflammatory response carried variationsTET2 and DMNT3A, both of which accumulate in genes over time.

Another research report published inCancersanalyzingpatients hospitalized with severe Covid-19disease found a much higher frequency of clonal hematopoiesis (CH) of indeterminate potential (sometimes called clonal hematopoiesis of indeterminate potential or CHIP) ),an age-associated condition in cells,in all age groups.

Additionally,accumulatedDNA damage to the JAK2 gene has been found in alargeproportion of cancer-free patients with venous thrombosis, a known complicationof Covid-19.While preliminary,the findingsdemonstratecompellingcorrelations betweensomaticgenetic change andCovid-19 severity that could be used to identify patients prone to complications early, intervene soonerand inform treatment strategies.

It is believed thatproviders can applythese correlations to other areas of care toassess an individuals susceptibilityto a wide range of diseases, and ultimately improve and extend quality of life.

Improving Care Decisions with Somatic insights Augmenting currenthealth assessmentsand care strategies with accumulated geneticdatacan open new pathways for disease detection, response and prevention.The scientificand medicalcommunitieshaveonly scratched the surface ofwhat we can learn from these insights. Even so,understanding somatic damage showsgreatpromise for helping individualsstay ahead of their health concerns and respond in a more informed way.

Photo: Andy, Getty Images

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Accumulated genetic variations: What they are and why they matter to a complete health picture - MedCity News

Repairing the Brain With Stem Cells? A Conversation With Prof. Jack Price – Being Patient

Groundbreaking research in stem cells has propelled scientists understanding of neurodegenerative diseases, including Parksinsons. Could stem cell therapies one day help cure Alzheimers?

Clinical trials of stem cell therapies are now underway to repair the damaged cells of people with Parkinsons disease and age-related macular degeneration. Being Patient spoke with Jack Price, professor of developmental neurobiology at Kings College London and author of the book The Future of Brain Repair, about the potential and challenges of repairing the brain with stem cell therapy.

Being Patient: What is stem cell therapy?

Prof. Jack Price: Its the transplantation of stem cells, either directly into the brain or in a way that gives them access to the brain and influence the brain, to bring about a therapeutic effect.

Being Patient: Are there stem cells in the brain?

Prof. Jack Price: For many years, neuroscientists didnt think there were stem cells in the brain. We now know there are. We know about a population [of stem cells] thats become very important in our understanding of Alzheimers disease and in mood disorders like anxiety and depression. These are stem cells that are found in a part of the brain called the hippocampus.

But by and large, the brain doesnt have stem cells, unlike skin and other tissues in the body. The blood is the classic [example]: Theres a population of stem cells in the bone marrow that regenerates blood all the time.

Being Patient: What makes stem cells so special and why are they a focus of research?

Prof. Jack Price: The definition of stem cells is a population of cells that gives rise to other types of cells. In neural stem cells, precursor cells can make adult brain cells, nerve cells, glial cells, all the different cell types that make up the brain. If you have a disease like Alzheimers or any other neurodegenerative disease, where we know the key pathology is the loss of nerve cells, your brain doesnt normally have the ability to replace those lost brain cells. The idea was [that] if you put stem cells where the loss of brain cells has taken place, maybe those stem cells would replace the lost cells.

Being Patient: What is the potential of stem cell therapy in treating neurodegenerative diseases?

Prof. Jack Price: Theres a piece of absolutely brilliant stem cell science that was done by Shinya Yamanaka in Kyoto in 2006. He showed you could effectively take any cell through a very straightforward genetic manipulation that he discovered, [and] turn them into what we call pluripotent stem cells, which are cells that can make any cell type in the body. They also have an ability that other stem cells generally dont: They can build tissue. If you grow them in a little culture dish, they can start to make little pieces of brain called organoids or cerebroids. This was a groundbreaking technology.

In Parkinsons disease, theres enormous progress and clinical trials are underway now. We know more about the pathology of Parkinsons disease [than in Alzheimers]. The pathology of Alzheimers turns out to be quite complex, and weve had, over the years, quite a few ideas about how it worked. But [turning] those into actual therapies hasnt quite worked as we expected, and we keep having to go back and rethink whats going on in Alzheimers.

The pathology of Parkinsons disease is also difficult. Its not trivial. But at the same time, one thing is clear: a lot of the pathology is associated with the loss of a particular population of nerve cells the midbrain dopaminergic cells. We can start with these pluripotent stem cells and make them make precisely the right type of dopaminergic cell that we know is lost in Parkinsons disease.

This is built on 30 [to] 40 years of research of people trying to find exactly the right cell type to work [with] in Parkinsons disease. They had some early success and fell backwards. But this technology looks much more precise than everything anybodys ever tried before.

In age-related macular degeneration, the disease of the eye where you lose your retinal photoreceptors, there are very clever strategies now where people are using these pluripotent stem cells to make a thing called a retinal pigment epithelium. It lies behind the retina, but its what supports the photoreceptors. It turns out, thats what goes wrong in age-related macular degeneration.

Being Patient: Are there any stem cell therapy approved to treat brain disorders?

Prof. Jack Price: There are no licensed stem cell therapy for any brain disorders anywhere in the world for the simple reason [that] nobody has shown one works. There are a lot of stem cell clinics in the U.S. and somewhat fewer elsewhere who are offering cell therapies that are untested. Theyll put stem cells into you for any disorder youve got. Those cell therapies do not work.

A lot of genuine companies are trying to get these cell therapies to work in clinical trials and falling flat on their face quite often, despite their best efforts. 90% of clinical trials fail, and thats clinical trials of conventional drugs by drug companies that know what theyre doing.

What do you suppose is the chance with a stem cell therapy [that] we dont really understand how it works, [that] we dont quite know how to manufacture it properly, [and that] we dont quite know what cells we really want, of working? The chance is almost zero. These companies know that, which is why theyre not going to clinical trials.

The interview has been edited for length and clarity.

Contact Nicholas Chan at nicholas@beingpatient.com

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Repairing the Brain With Stem Cells? A Conversation With Prof. Jack Price - Being Patient

Global Induced Pluripotent Stem Cells Market Size, Comprehensive Analysis, Development Strategy, Future Plans and Industry Growth with High CAGR by…

Global Induced Pluripotent Stem Cells Market Report, History and Forecast 2015-2026, Breakdown Data by Companies, Key Regions, Types and Application

The Lexis Business Insights added a new report Global Induced Pluripotent Stem Cells Market: Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2016 2024 in its database, which provides an expert and in-depth analysis of key business trends and future market development prospects, key drivers and restraints, profiles of major market players, segmentation and forecasting.

In 2020, the global Induced Pluripotent Stem Cells Market size was xx million US$ and it is expected to reach xx million US$ by the end of 2025, with a CAGR of xx% during 2020-2025.

The global Induced Pluripotent Stem Cells Market report offers a complete overview of the Induced Pluripotent Stem Cells Market globally. It presents real data and statistics on the inclinations and improvements in global Induced Pluripotent Stem Cells Markets. It also highlights manufacturing, abilities & technologies, and unstable structure of the market. The global Induced Pluripotent Stem Cells Market report elaborates the crucial data along with all important insights related to the current market status.

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Top key players @ Fujifilm Holding Corporation, Astellas Pharma, Fate Therapeutics, Bristol-Myers Squibb Company, ViaCyte, Celgene Corporation, Aastrom Biosciences, Acelity Holdings, StemCells, Japan Tissue Engineering, Organogenesis, and

The main goal for the dissemination of this information is to give a descriptive analysis of how the trends could potentially affect the upcoming future of Induced Pluripotent Stem Cells market during the forecast period. This markets competitive manufactures and the upcoming manufactures are studied with their detailed research. Revenue, production, price, market share of these players is mentioned with precise information.

Global Induced Pluripotent Stem Cells Market: Regional Segment Analysis

This report provides pinpoint analysis for changing competitive dynamics. It offers a forward-looking perspective on different factors driving or limiting market growth. It provides a five-year forecast assessed on the basis of how they Induced Pluripotent Stem Cells Market is predicted to grow. It helps in understanding the key product segments and their future and helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments.

Key questions answered in the report include:

What will the market size and the growth rate be in 2026?

What are the key factors driving the Global Induced Pluripotent Stem Cells Market?

What are the key market trends impacting the growth of the Global Induced Pluripotent Stem Cells Market?

What are the challenges to market growth?

Who are the key vendors in the Global Induced Pluripotent Stem Cells Market?

What are the market opportunities and threats faced by the vendors in the Global Induced Pluripotent Stem Cells Market?

Trending factors influencing the market shares of the Americas, APAC, Europe, and MEA.

The report includes six parts, dealing with:

1.) Basic information;

2.) The Asia Induced Pluripotent Stem Cells Market;

3.) The North American Induced Pluripotent Stem Cells Market;

4.) The European Induced Pluripotent Stem Cells Market;

5.) Market entry and investment feasibility;

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The report analyzes the factors impacting the growth and the current market trends influencing the global Induced Pluripotent Stem Cells market. Detailed pricing information with ex-factory prices of various products by key manufacturers form a crucial part of the report. Competition analysis, along with regional government policies affecting the Induced Pluripotent Stem Cells market provides a detailed overview of the current status and prospects of the market. The impact of the ever-growing global population, coupled with technological advancements affecting the global Induced Pluripotent Stem Cells market is also covered in the report.

Drivers & Constraints

The report provides extensive information about the factors driving the global Induced Pluripotent Stem Cells market. Factors influencing the growth of the Induced Pluripotent Stem Cells market, along with technological advancements, are discussed extensively in the report. The current restraints of the market, limiting the growth and their future impact are also analyzed in the report. The report also discusses the impact of rising consumer demand, along with global economic growth on the Induced Pluripotent Stem Cells market.

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It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments

TABLE OF CONTENT:

1 Report Overview

2 Global Growth Trends

3 Market Share by Key Players

4 Breakdown Data by Type and Application

5 United States

6 Europe

7 China

8 Japan

9 Southeast Asia

10 India

11 Central & South America

12 International Players Profiles

13 Market Forecast 2019-2025

14 Analysts Viewpoints/Conclusions

15 Appendix

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Global Induced Pluripotent Stem Cells Market Size, Comprehensive Analysis, Development Strategy, Future Plans and Industry Growth with High CAGR by...

Industry Verticals: Induced Pluripotent Stem Cells (iPSC) Market Latest and updated Scope and Application 2020-2027 – The Blend

The global induced pluripotent stem cells (ipsc) market is estimated to surpass $2,638.5 million by 2027, exhibiting a CAGR of 7.8% from 2020 to 2027.

The report aims to offer a clear picture of the current scenario and future growth of the global Induced Pluripotent Stem Cells (iPSC) market. The report provides scrupulous analysis of global market by thoroughly reviewing several factors of the market such as vital segments, regional market condition, market dynamics, investment suitability, and key players operating in the market. Besides, the report delivers sharp insights into present and forthcoming trends & developments in the global market.

The report articulates the key opportunities and factors propelling the global Induced Pluripotent Stem Cells (iPSC) market growth. Also, threats and limitations that have the possibility to hamper the market growth are outlined in the report. Further, Porters five forces analysis that explains the bargaining power of suppliers and consumers, competitive landscape, and development of substitutes in the market is also sketched in the report.

For More Detail Insights, Download Sample Copy of the Report at:https://www.researchdive.com/download-sample/759

The report reveals various statistics such as predicted market size and forecast by analyzing the major factors and by assessing each segment of the global Induced Pluripotent Stem Cells (iPSC) market. Regional market analysis of these segments is also provided in the report. The report segments the global market into four main regions including Asia-Pacific, Europe, North America, and LAMEA. Moreover, these regions are sub-divided to offer an exhaustive landscape of the Induced Pluripotent Stem Cells (iPSC) market across key countries in respective regions. Furthermore, the report divulges some of the latest advances, trends, and upcoming opportunities in every region.

Furthermore, the report profiles top players active in the global Induced Pluripotent Stem Cells (iPSC) market. A comprehensive summary of 10 foremost players operating in the global market is delivered in the report to comprehend their position and footmark in the industry. The report highlights various data points such as short summary of the company, companys financial status and proceeds, chief company executives, key business strategies executed by company, initiatives undertaken & advanced developments by the company to thrust their position and grasp a significant position in the market.

RESEARCH METHODOLOGY

The research report is formed by collating different statistics and information concerning the Induced Pluripotent Stem Cells (iPSC) market. Long hours of deliberations and interviews have been performed with a group of investors and stakeholders, including upstream and downstream members. Primary research is the main part of the research efforts; however, it is reasonably supported by all-encompassing secondary research. Numerous product type literatures, company annual reports, market publications, and other such relevant documents of the leading market players have been studied, for better & broader understanding of market penetration. Furthermore, medical journals, trustworthy industry newsletters, government websites, and trade associations publications have also been evaluated for extracting vital industry insights.

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KEY MARKET BENEFITS

KEY MARKET SEGMENTS

The global Induced Pluripotent Stem Cells (iPSC) market is segmented on the basis of the following:

Global Induced Pluripotent Stem Cells (iPSC) Market By Product Type:

Global Induced Pluripotent Stem Cells (iPSC) Market By Applications:

Global Induced Pluripotent Stem Cells (iPSC) Market By Regions:

Top Leading key players stated in Global Induced Pluripotent Stem Cells (iPSC) Market report are:

Axol Bioscience Ltd., Cell Applications, Inc, Cellular Dynamics, Inc., Cynata Therapeutics, Fate Therapeutics, Ncardia, Reprocell, Thermo Fisher Scientific, Takara Bio, Inc.

The report also summarizes other important aspects including financial performance, product portfolio, SWOT analysis, and recent strategic moves and developments of the leading players.

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Industry Verticals: Induced Pluripotent Stem Cells (iPSC) Market Latest and updated Scope and Application 2020-2027 - The Blend

Bayer Launches Cell and Gene Therapy Platform to Maximize Recent Acquisitions – PharmaLive

Less than two months after life sciences giant Bayer acquired N.C.-based AskBio, a gene therapy company, the healthcare giant launched a cell and gene therapy platform within its pharmaceutical division.

This morning, Bayer said the launch of the new platform is a deeply transformative move for its business. Stefan Oelrich, a member of Bayers Board of Management and president of the companys Pharmaceuticals Division, pointed to the impact cell and gene therapies have made in treating diseases and said the companys goal is to be at the forefront of this revolution in science. The company tapped Wolfram Carius, its current vice president of Pharmaceuticals Product Supply, to head the new program.

The C> field is growing at an unprecedented pace. With the establishment of Bayers own C> Platform our company will propel its presence in this area. This will complement our existing C> pipeline which already includes five advanced assets with at least three investigational new drugs annually for the next years, Oelrich said in a statement.

To boost its cell and gene therapy presence, Bayer said it is strengthening its internal capabilities and will also pursue external strategic collaborations, technology acquisitions and licensing. In October, the company acquired AskBios AAV-based gene therapy pipeline of treatments and its Pro10 AAV manufacturing process, which has become something of a standard across the industry. The Pro10 AAV process is used by multiple companies, including Pfizer, Takeda and Viralgen Vector Core SA.Bayer now owns AskBios pipeline of treatments for Pompe disease, Parkinsons disease, as well as therapies for neuromuscular, central nervous system, cardiovascular and metabolic diseases.

The addition of AskBio complements Bayers other cell and gene therapy company, BlueRock Therapeutics, which itacquired last year. BlueRock is developing induced pluripotent stem cells (iPSC), with its most advanced program aimed at Parkinsons disease. In addition to the two companies, Bayer also acquired a contract manufacturing organization that specializes in gene therapy. Bayer said it has established a C> pipeline that includes five advanced assets and more than fifteen preclinical candidates.

The new C> Platform will combine multiple functions by providing support across the entire value chain for the research and development of cell and gene therapies, the company said. This includes support in preclinical development, CMC, clinical programs, project management and more. The platform will guide projects form concept through commercial launch. The goal is to build robust platforms with broad application across different therapeutic areas, the company said.

The emerging bio revolution represents a once-in-a-lifetime opportunity and a new era for Bayer, said Carius said in a statement. A dedicated C> Platform is vital to accelerate innovation at its source, and to ensure its translation into tangible therapies for patients who have no time to wait.

The C> Platform will allow its partners to operate autonomously to develop and progress their portfolio and technology. The role of Bayers C> Platform is to serve as a strategic guide to ensure the different parts of the organization complement each other and combine the best in Biotech and Pharma know-how.

nitpicker/Shutterstock

The formation of the C> Platform comes one day after Bayer and Blackford Analysis entered into a development and license agreement to establish an artificial intelligence (AI) platform for medical imaging. The platform will enable the integration of AI applications into the medical imaging workflow which can support the complex decision-making process of radiologists and is intended to enhance diagnostic confidence, the companies said.

Also this week, Bayer sold most of its stake in Elanco Animal Health for $1.6 billion to cover legal bills from ongoing litigation over the weedkiller Roundup and its alleged role as a carcinogen. Bayer owned approximately 15.5% of Elanco, but faces nearly $11 billion in potential damages related to Roundup lawsuits. In June, the company proposed a $12 billion agreement to resolve Roundup litigation.

Last week, a federal judge rejected a $650 million settlement claim for pollution related to polychlorinated biphenyl, or PCB, which is used to cool heavy-duty electrical equipment.

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Bayer Launches Cell and Gene Therapy Platform to Maximize Recent Acquisitions - PharmaLive

Stem Cells Market Size on Target to Reach US$ 17.79 Billion 2027 – Cheshire Media

The Global Stem Cells Market size is projected to reach US$ 17.79 Billion by 2027, registering a CAGR of 8.61% during the forecast period 2020 to 2027.The market report provides an analysis of the global Stem Cells Market for the period 2016-2027, wherein 2020 to 2027 is the forecast period and 2019 is considered as the base year.

COVID-19 pandemic has impacted all over industries across the globe, and Stem Cells Market is one of them. As the global market heads towards major recession, we are at Precedence Research, has published a brand-new latest research report which fully studies the impact of COVID-19 crisis on Stem Cells Industry and suggests possible actions to curtail them. This market report covers an in-depth analysis of the Stem Cells industry including statistical, quantitative, qualitative data points with emphasis on the market dynamics including the growth factors, drivers, opportunities & restraints, market size, share, industry status and forecast, competition landscape and growth and revenue opportunities after COVID-19 pandemic.

The Final Report will cover the impact analysis of COVID-19, Get a FREE SAMPLE PDF (Including Full TOC, Table & Figures) @https://www.precedenceresearch.com/sample/1118

The report gives correct insights on the current market scenario and future prospects of theStem Cellsindustry. It expertly describes historic data, present market trends, market environment, technological improvements, upcoming technologies and the technical progress in the related industry. Top market leaders, major collaborations, mergers & acquisitions are reviewed comprehensively in theStem Cellsmarket report.

Moreover, this market study also analyses the market status, market share, growth rate (CAGR), future trends, market drivers, opportunities and challenges, sales channels, distributors and Porters Five Forces Analysis. Market risks and entry barriers makes the Stem Cells industry attentive and help to decide further moves.

Stem Cells Market 2020 to 2027 Analysis and Segmentation:

Competitive Landscape:

The competitive landscape of the market has been studied in the report with the detailed profiles of the key players operating in the market.

Some of these key players include:

Get Customization on this Research [emailprotected]https://www.precedenceresearch.com/customization/1118

Market Segmentation as below:

Segments Covered in the Report

This research study comprises complete assessment of the market by means of far-reaching qualitative and quantitative perceptions, and predictions regarding the market. This report delivers classification of marketplace into impending and niche sectors. Further, this research study calculates market size and its development drift at global, regional, and country from 2016 to 2027. This report contains market breakdown and its revenue estimation by classifying it on the basis of product, application, technology, therapy and region as follows:

By Product

By Application

By Technology

By Therapy

Market By Geography (Regional Output, Demand & Forecast by Countries)

Along with these, for proper market understanding, the major aspects like economic, social, political, and environmental, along with the major regulations and standards in accordance with the Stem Cells Market are covered. For the same, Porters five forces model, value chain analysis, cost structure analysis, and player positioning analysis are covered.

The 2020 Annual Stem Cells Market Offers:

100 + charts exploring and analyzing the Stem Cells Market from critical angles including retail forecasts, consumers demand, production, and more

10 + profiles of topStem CellsMarket producing states, with highlights of market conditions and retail trends

Regulatory outlook, best practices, and future considerations for manufacturers and industry players seeking to meet consumer demand

Highlights of the Report:

The research provides answers to the following key questions:

The Final Report will cover the impact analysis of COVID-19.

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Stem Cells Market Size on Target to Reach US$ 17.79 Billion 2027 - Cheshire Media

Bayer establishes Cell and Gene Therapy Platform to accelerate pharmaceutical innovation | More News | News Channels – PipelineReview.com

Details Category: More News Published on Thursday, 03 December 2020 11:22 Hits: 540

BERLIN, Germany I December 2, 2020 I Bayer AG announced today the launch of a Cell and Gene Therapy (C>) Platform within its Pharmaceuticals division. Through this strategic platform, the company further consolidates its emerging leadership in the field and takes a deeply transformative step for its business.

This is a defining moment for Bayer. Cell and gene therapies are leading innovation in healthcare, and it is our goal to be at the forefront of this revolution in science, said Stefan Oelrich, Member of the Board of Management, Bayer AG and President Pharmaceuticals Division. The C> field is growing at an unprecedented pace. With the establishment of Bayers own C> Platform our company will propel its presence in this area. This will complement our existing C> pipeline which already includes five advanced assets with at least three investigational new drugs annually for the next years.

In order to build up its presence in C>, Bayer is strengthening its internal C> capabilities. At the same time, the company is pursuing external strategic collaborations, technology acquisitions and licensing. The goal is to build robust platforms with broad application across different therapeutic areas. For example, Bayer has just acquired an industry-leading contract manufacturing organization in gene therapy. Together with Bayers expertise and recent investments in product supply capabilities, this will contribute to fill an important global demand gap for development and manufacturing of gene therapies.

Strategically, Bayer focuses on selected areas of C>, such as stem cell therapies (with focus on induced pluripotent cells or iPSCs), gene augmentation, gene editing and allogeneic cell therapies in different indications. With the acquisition of BlueRock Therapeutics in 2019 and the recent acquisition of Asklepios Biopharmaceutical, successfully closed on December 1, 2020, the first partners are integrating into Bayers C> Platform. Furthermore, the company has secured industry-leading expertise in the areas of gene augmentation and regenerative cell therapies. Bayer has also established a vibrant C> pipeline comprising five advanced assets and over fifteen preclinical candidates.

Leveraging external innovation together with the expertise of the teams at Bayer represents a key value-driver, especially in the highly dynamic and competitive field of C>. Bayers operating model for C>, where partners operate autonomously and are fully accountable to develop and progress their portfolio and technology, is essential for preserving their entrepreneurial culture and positions Bayer as a partner of choice. The role of Bayers C> Platform is to steer strategically, ensuring the different parts of the organization complement each other and combining the best in Biotech and Pharma know-how.

The emerging bio revolution represents a once-in-a-lifetime opportunity and a new era for Bayer, said Wolfram Carius, Head of Bayers new C> Platform. A dedicated C> Platform is vital to accelerate innovation at its source, and to ensure its translation into tangible therapies for patients who have no time to wait.

As part of the Pharmaceuticals Division, the C> Platform will combine multiple backbone functions providing support across the entire value chain for the research and development of cell and gene therapies. This includes expertise in Research and Preclinical Development, CMC (Chemistry, Manufacturing and Controls), Clinical Development, Commercial, Strategy Implementation and Project Management. With a high level of flexibility, it will orchestrate operations from science to launch in order to generate and maintain a sustainable pipeline, with the goal to bring breakthrough science to market as fast as possible.

About Bayer Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Its products and services are designed to benefit people by supporting efforts to overcome the major challenges presented by a growing and aging global population. At the same time, the Group aims to increase its earning power and create value through innovation and growth. Bayer is committed to the principles of sustainable development, and the Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2019, the Group employed around 104,000 people and had sales of 43.5 billion euros. Capital expenditures amounted to 2.9 billion euros, R&D expenses to 5.3 billion euros. For more information, go to http://www.bayer.com.

SOURCE: Bayer

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Bayer establishes Cell and Gene Therapy Platform to accelerate pharmaceutical innovation | More News | News Channels - PipelineReview.com

Stem Cell Manufacturing Market Analysis by Industry Size, Share, Key Drivers, Growth Factors, Demands, Top Manufacturers- Merck Group, Becton,…

A new research document is added in DBMR database of 350 pages, titled as Stem Cell Manufacturing Market with detailed analysis, Competitive landscape, forecast and strategies. This overview includes the market definition, key applications of the product, and the recent manufacturing technology employed for such production. This also report provide the details about industry overview and analysis about size, share, growth, trend, demand, outlook, classification revenue details, competitive scenario, industry analysis, Markets forecast, manufacturers with development trends and forecasts 2027. This research refines variations of the Stem Cell Manufacturing market to help you in planning the general strategy. The document is provided in readily possible records that uncover tables, charts, figures, structured presentations, pie graphs, and other visual portrayals.

Stem cell manufacturing is forecasted to grow at CAGR of 6.42% to an anticipated value of USD 18.59 billion by 2027 with factors like rising awareness towards diseases like cancer, degenerative disorders and hematopoietic disorders is driving the growth of the market in the forecast period of 2020-2027.

Download Exclusive Sample (350 Pages PDF) Report: To Know the Impact of COVID-19 on thisIndustry@https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-stem-cell-manufacturing-market&AB

Stem cell manufacturing has shown an exceptional penetration in North America due to increasing research in stem cell. Increasing research and development activities in biotechnology and pharmaceutical sector is creating opportunity for the stem cell manufacturing market.

The Global Stem Cell Manufacturing Market 2020 research provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Global Stem Cell Manufacturing Market Share analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. Development policies and plans are discussed as well as manufacturing processes and cost structures are also analyzed.

Global Stem Cell Manufacturing Market Segematation By Product (Stem Cell Line, Instruments, Culture Media, Consumables), Application (Research Applications, Clinical Applications, Cell and Tissue Banking), End Users (Hospitals and Surgical Centers, Pharmaceutical and Biotechnology Companies, Clinics, Community Healthcare, Others)

List of TOP KEY PLAYERS in Stem Cell Manufacturing Market Report are

Thermo Fisher Scientific Merck KGaA BD JCR Pharmaceuticals Co., Ltd Organogenesis Inc Osiris Vericel Corporation AbbVie Inc AM-Pharma B.V ANTEROGEN.CO.,LTD Astellas Pharma Inc Bristol-Myers Squibb Company FUJIFILM Cellular Dynamics, Inc RHEACELL GmbH & Co. KG Takeda Pharmaceutical Company Limited Teva Pharmaceutical Industries Ltd ViaCyte,Inc VistaGen Therapeutics Inc GlaxoSmithKline plc ..

Complete Report is Available (Including Full TOC, List of Tables & Figures, Graphs, and Chart)@https://www.databridgemarketresearch.com/toc/?dbmr=global-stem-cell-manufacturing-market&AB

The report can help to understand the market and strategize for business expansion accordingly. In the strategy analysis, it gives insights from marketing channel and market positioning to potential growth strategies, providing in-depth analysis for new entrants or exists competitors in the Stem Cell Manufacturing industry. This report also states import/export consumption, supply and demand Figures, cost, price, revenue and gross margins. For each manufacturer covered, this report analyzes their Stem Cell Manufacturing manufacturing sites, capacity, production, ex-factory price, revenue and market share in global market.

The Global Stem Cell Manufacturing Market Trends, development and marketing channels are analysed. Finally, the feasibility of new investment projects is assessed and overall research conclusions offered.

Global Stem Cell Manufacturing Market Scope and Market Size

Stem cell manufacturing market is segmented on the basis of product, application and end users. The growth amongst these segments will help you analyse meagre growth segments in the industries, and provide the users with valuable market overview and market insights to help them in making strategic decisions for identification of core market applications.

Based on product, the stem cell manufacturing market is segmented into stem cell lines, instruments, culture media and consumables. Stem cell lines are further segmented into induced pluripotent stem cells, embryonic stem cells, multipotent adult progenitor stem cells, mesenchymal stem cells, hematopoietic stem cells, neural stem cells. Instrument is further segmented into bioreactors and incubators, cell sorters and other instruments.

On the basis of application, the stem cell manufacturing market is segmented into research applications, clinical applications and cell and tissue banking. Research applications are further segmented into drug discovery and development and life science research. Clinical applications are further segmented into allogenic stem cell and autologous stem cell therapy.

On the basis of end users, the stem cell manufacturing market is segmented into hospitals and surgical centers, pharmaceutical and biotechnology companies, research institutes and academic institutes, community healthcare, cell banks and tissue banks and others.

Healthcare Infrastructure growth Installed base and New Technology Penetration

Stem cell manufacturing market also provides you with detailed market analysis for every country growth in healthcare expenditure for capital equipment, installed base of different kind of products for stem cell manufacturing market, impact of technology using life line curves and changes in healthcare regulatory scenarios and their impact on the stem cell manufacturing market. The data is available for historic period 2010 to 2018.

The Global Stem Cell Manufacturing Market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of stem cell manufacturing market for global, Europe, North America, Asia Pacific and South America.

Key Insights in the report:

Historical and current market size and projection up to 2025

Market trends impacting the growth of the global taste modulators market

Analyze and forecast the taste modulators market on the basis of, application and type.

Trends of key regional and country-level markets for processes, derivative, and application Company profiling of key players which includes business operations, product and services, geographic presence, recent developments and key financial analysis

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Opportunities in the market

To describe and forecast the market, in terms of value, for various segments, by region North America, Europe, Asia Pacific (APAC), and Rest of the World (RoW)

The key findings and recommendations highlight crucial progressive industry trends in the Stem Cell manufacturing Market, thereby allowing players to develop effective long term strategies

To strategically profile key players and comprehensively analyze their market position in terms of ranking and core competencies, and detail the competitive landscape for market leaders Extensive analysis of the key segments of the industry helps in understanding the trends in types of point of care test across Europe.

To get a comprehensive overview of the Stem Cell manufacturing market.

With tables and figures helping analyses worldwide Global Stem Cell Manufacturing Market Forecast this research provides key statistics on the state of the industry and is a valuable source of guidance and direction for companies and individuals interested in the market. There are 15 Chapters to display the Stem Cell Manufacturing market.

Chapter 1, About Executive Summary to describe Definition, Specifications and Classification of Stem Cell Manufacturing market, By Product Type, by application, by end users and regions.

Chapter 2, objective of the study.

Chapter 3, to display Research methodology and techniques.

Chapter 4 and 5, to show the Stem Cell Manufacturing Market Analysis, segmentation analysis, characteristics;

Chapter 6 and 7, to show Five forces (bargaining Power of buyers/suppliers), Threats to new entrants and market condition;

Chapter 8 and 9, to show analysis by regional segmentation[North America, Europe, Asia-Pacific etc ], comparison, leading countries and opportunities; Regional Marketing Type Analysis, Supply Chain Analysis

Chapter 10, to identify major decision framework accumulated through Industry experts and strategic decision makers;

Chapter 11 and 12, Stem Cell Manufacturing Market Trend Analysis, Drivers, Challenges by consumer behavior, Marketing Channels

Chapter 13 and 14, about vendor landscape (classification and Market Ranking)

Chapter 15, deals with Stem Cell Manufacturing Market sales channel, distributors, Research Findings and Conclusion, appendix and data source.

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia or Oceania [Australia and New Zealand]

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Stem Cell Manufacturing Market Analysis by Industry Size, Share, Key Drivers, Growth Factors, Demands, Top Manufacturers- Merck Group, Becton,...