Induced Pluripotent Stem Cells Market 2020 Is Slated to Grow Rapidly in the Forthcoming Years with Key Players Addgene, Axol Bioscience, Cell…

This analysis of the Global Induced Pluripotent Stem Cells Market aims to offer relevant and well-researched insights into the contemporary market scenario and the emergent growth dynamics. The report on Induced Pluripotent Stem Cells Market also gives the market players and fresh contenders a holistic view of the global market landscape.

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New York, NY -- (SBWIRE) -- 10/13/2020 -- The latest report titled 'Global Induced Pluripotent Stem Cells Market (COVID-19 Impact Analysis)', published by Reports and Data, offers a bird's eye view of the global Induced Pluripotent Stem Cells market, covering the latest market trends, industry insights, and market share. The report provides an in-depth, strategic analysis of the Induced Pluripotent Stem Cells industry, with prime focus on each segment and sub-segment of the market. Market forecasts included in the report hold great significance as they provide deep insight into the various industry parameters by evaluating the global market growth and consumption rates, volatility in demand and product prices, and upcoming market trends.

The report scrutinizes several key aspects of the global market, including the latest innovations in the industry, technological advancements, rising trends, and opportunities for growth. The SWOT analysis, coupled with an overview of the competitive landscape, forms a vital component of the report.

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The report offers full coverage of the current market scenario, which has been adversely impacted by the ongoing COVID-19 pandemic. The global health crisis has affected nearly every aspect of this industry domain. Hence, the latest study provides some important speculations of the future outcomes of the pandemic's impact on the global economy that could help businesses gear up and take precautionary measures.

Leading Companies in the Global Induced Pluripotent Stem Cells Market:

Thermo Fisher Scientific, Allele Biotechnology and Pharmaceuticals Inc., ABM (Applied Biological Materials Inc.), Addgene, Axol Bioscience, Cell Signaling Technology, Bluerock Therapeutics, Alstem LLC, Applied Stemcell Inc., ATCC, Creative Bioarray, Bristol-Myers Squibb, Bio-Techne, Reprocell Group Co., Primorigen Biosciences, ID Pharma Co. Ltd., Megakaryon Corp., FUJIFILM Cellular Dynamics, Inc., Waisman Biomanufacturing, Roslin Cell Sciences, Opsis Therapeutics, Corning Life Sciences, Fate Therapeutics, Genecopoeia, Gentarget Inc., Viacyte Inc., Ncardia, Invivogen, Lonza Group Ltd., Plasticell Ltd., Stemcell Technologies, Newcells Biotech, Orig3N Inc., Peprotech, Promega Corp., Promocell Gmbh, Qiagen N.V., System Biosciences Inc., Reprocell Inc., Sciencell Research Laboratories, MilliporeSigma, and Takara Bio Usa Inc.

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Global Induced Pluripotent Stem Cells Market Segmentation by Product Type:

Amniotic Cells

Fibroblasts

Keratinocytes

Hepatocytes

Others

Global Induced Pluripotent Stem Cells Market Segmentation by Application:

Drug Development

Toxicity Testing

Regenerative Medicine

Academic

Global Induced Pluripotent Stem Cells Market segmentation by Region/Country:

North America

Europe

Asia Pacific

Latin America

Middle East & Africa

Key Takeaways from the Global Induced Pluripotent Stem Cells Market Report:

Full coverage of the global Induced Pluripotent Stem Cells market analysis

Market Mechanism and Dynamics

Fluctuating market trends and market developments

Systematic market segmentation

Historical, current, and projected market size

Competitive outlook

Expansion strategies adopted by key players

Product offerings

Niche segments/regions exhibiting potential growth

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The report carries a neutral perspective towards the global market performance

The report analyzes the changing competitive scenario.

The analytical data and strategic planning methodologies are expected to aid businesses in decision-making

Proffers a seven-year assessment of the global market, elaborating on the key product segments

Market dynamics, such as drivers, opportunities, restraints, and threats, have been listed in the report

The report presents an exhaustive regional analysis of the global Induced Pluripotent Stem Cells market and lists the business profiles of various stakeholders.

It also provides significant data about the critical factors influencing market progress

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Induced Pluripotent Stem Cells Market 2020 Is Slated to Grow Rapidly in the Forthcoming Years with Key Players Addgene, Axol Bioscience, Cell...

Novellus Therapeutics Exclusively Licenses Induced Mesenchymal Stem Cells (iMSCs) to NoveCite for COVID-19 Related Acute Respiratory Distress Syndrome…

Novellus Therapeutics Exclusively Licenses Induced Mesenchymal Stem Cells (iMSCs) to NoveCite

"Novellus's iMSCs have the potential to be a breakthrough in the field of cellular therapy for acute respiratory conditions because of their high potency as demonstrated in our pre-clinical studies, as well as our ability to cost-effectively provide high doses and repeat doses." said Myron Holubiak, CEO of Citius.

"We are excited to be developing iMSCs because of their promise to save lives and reduce long term sequelae in patients with devastating respiratory diseases such as ARDS caused by COVID-19," said Matt Angel, Chief Science Officer of Novellus. He continued, "Our iMSCs have multimodal immunomodulatory mechanisms of action that make them promising for treatment of acute respiratory diseases."

About Novellus Therapeutics LimitedNovellus is a pre-clinical stage biotechnology company developing engineered cellular medicines using its patented non-immunogenic mRNA, high-specificity gene editing, mutation-free & footprint-free cell reprogramming and serum-insensitive mRNA lipid delivery technologies. Novellus is privately held and is headquartered in Cambridge, MA. For more information, please visit http://www.novellustx.com.

About NoveCite, Inc.NoveCite, Inc. is a newly formed subsidiary of Citius Pharmaceuticals, a late-stage specialty pharmaceutical company dedicated to the development and commercialization of critical care products, with a focus on anti-infectives and cancer care. For more information, please visit http://www.citiuspharma.com.

Contact: [emailprotected]

SOURCE Novellus Therapeutics

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Novellus Therapeutics Exclusively Licenses Induced Mesenchymal Stem Cells (iMSCs) to NoveCite for COVID-19 Related Acute Respiratory Distress Syndrome...

Brain organoids reveal neuronal flaws in syndrome tied to autism – Spectrum

Electric organoid: Neurons derived from people with 22q11.2 syndrome are hyperexcitable and show calcium-signaling deficits.

Courtesy of Pasca lab

Neurons derived from people with 22q11.2 deletion syndrome, a genetic condition linked to autism, show deficits in electrical activity and calcium signaling, according to a new study1. A single gene appears to be largely responsible for these defects, the study shows.

Up to 20 percent of people who lack part or all of the chromosomal region 22q11.2 have autism. Individuals with the deletion may also have schizophrenia, seizures, heart defects, immune dysfunction or learning problems.

The new findings uncover factors that may contribute to the development of psychiatric conditions associated with 22q11.2 deletion syndrome. They could also help researchers identify new therapeutic targets, says lead author Sergiu Pasca, associate professor of psychiatry and behavioral sciences at Stanford University in California.

The syndrome is relatively common, occurring in up to 1 in 4,000 newborns, Pasca says. But researchers do not fully understand how genes in the 22q11.2 region contribute to autism or other conditions, he adds.

To solve this molecular puzzle, Pasca and his team reprogrammed skin cells from 15 people with the deletion and 15 controls into induced pluripotent stem cells. Using a technique they developed in 2015, they coaxed these cells to turn into neurons, which self-organize in a dish into spherical clusters called organoids. The organoids show some key features of the developing cerebral cortex, a brain region implicated in autism.

The neurons derived from people with 22q11.2 syndrome spontaneously fire four times as frequently as neurons derived from controls, the researchers found. And the electrical activity of the 22q cells does not set off the usual spike in calcium levels, which is crucial for neurons to exchange messages.

In some other syndromes tied to schizophrenia and autism, calcium-channel genes are mutated. But the number of channels and the speed at which they work in 22q neurons is the same as in control neurons. Instead, the 22q cells show an unusually low voltage difference across the cell membrane when they arent firing, causing the signaling defects and hyperexcitability, the researchers found.

The researchers suspected that a gene called DGCR8 might be responsible for the neuronal deficits in the organoids because it lies within 22q11.2 and is linked to abnormal electrical activity in the neurons of mice2. DGCR8 is essential for the synthesis of short RNA fragments, called microRNAs, that regulate gene expression.

Lowering DGCR8s expression levels in control neurons reproduced the abnormalities seen in 22q neurons. In contrast, boosting the genes activity in 22q neurons or treating them with antipsychotic drugs prevented them from being overly excitable and reversed their calcium-signaling defects. The study was published 28 September in Nature Medicine.

Previous studies have analyzed lab-grown neurons derived from people with schizophrenia or autism-related disorders such as Rett and fragile X syndromes. But most used only a few human-derived cell lines, says Guo-li Ming, professor of neuroscience at the University of Pennsylvania in Philadelphia. The new study, Ming says, has a total of 30 human lines thats a huge effort.

By studying brain organoids derived from so many people, the researchers were able to identify the gene that might be involved in the psychiatric conditions associated with 22q11.2 syndrome, says Sally Temple, scientific director of the Neural Stem Cell Institute in Rensselaer, New York. Whenever we have a light shining ahead, saying, This is what you should really be looking at, it means that were making progress, she says.

The study participants with 22q11.2 syndrome vary in their psychiatric diagnoses, and yet all the brain organoids derived from their cells show the same neuronal abnormalities. Thats somewhat surprising, because we know there are a lot of differences in the genetic background of different people, Ming says.

The deletion might conspire with other factors to ultimately determine which psychiatric conditions a person has, Pasca says. It could be that the deletion causes cellular defects, and once there is a stressor such as social stress, disease develops. Its also unclear whether these cellular defects are related to the high prevalence of seizures in people with 22q11.2 syndrome, he says.

The hallmarks of most neuropsychiatric conditions can change over time, says Giuseppe Testa, director of the stem cell epigenetics unit at the European Institute of Oncology in Milan, Italy. Studies that look at a larger number of people with 22q11.2 deletion syndrome or other neurodevelopmental conditions could help to elucidate the relationship between the neuronal defects observed in the lab and the psychiatric manifestations of the conditions, Testa says. The new study, however, is a great resource for understanding how the 22q11.2 deletion contributes to schizophrenia and autism, he says.

Pascas team is trying to pinpoint molecules that could open new therapeutic avenues for 22q11.2 deletion syndrome. The antipsychotics they tested restore the unusual voltage differences in the 22q neurons, but they dont address the core mechanisms responsible for psychiatric conditions linked to the syndrome, Pasca says.

Whats more, antipsychotics have many side effects, and not all individuals respond to them, he says. We need better therapies we need to identify what the key molecular players are and target those.

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Brain organoids reveal neuronal flaws in syndrome tied to autism - Spectrum

Disruptive Technologies and Mature Regulatory Environment Vital for Cell Therapy Maturation – BioSpace

Immuno-oncology and CAR T cells energized the field of regenerative medicine, but for cell and gene to deliver on their promises, new, disruptive technologies and new modes of operation are needed. Specifically, that entails improving manufacturing to control variables and thus ensure product consistency, and maturing the regulatory environment to improve predictability.

Manufacturing cells is not like manufacturing small molecules, Brian Culley, CEO of Lineage Cell Therapeutics, told BioSpace. For cell therapy products to mature into real products that deliver on the promises of 10 years ago, they must be scalable which drives affordability and they must solve their purity issues.

On the clinical side, cell and gene therapies must find places where small molecules, antibodies or other traditional approaches may not be the best option.

For example, The era of transplant medicine is unfolding before us, Culley said. Because of the transplant component, cell therapy may enable changes the body never could do alone.

Lineage is addressing dry AMD and spinal cord injuries with two of its therapeutics.

Our approach is fundamentally different from traditional approaches. We replace the entire cell rather than modulate a pathway. There is a rational hypothesis where cell therapy can win, but first we need to fix the operational hurdles, Culley said.

To address the manufacturing challenges, Culley said, We work only with allogeneic approaches. For us, not being patient-specific is a huge advantage.

Not long ago, the industry was focused on 3D manufacturing in bioreactors.

Were beyond that, Culley said. For our dry AMD product, we can manufacture 5 billion retinal cells in a three liter bioreactor. The advantage is that the cells exist in a very homogenous space and are 99% pure.

As a result, they are more affordable and can be harvested with little manipulation.

Manual manipulation affects gene expression, he pointed out, so minimizing that, as well as the vast quantities of plastics typically required, results in a more controlled process and a more consistent product.

Additionally, Lineage introduced a thaw and inject formulation, so the cell therapy can be thawed in a water bath, loaded into a chamber and injected, all within a few minutes. Traditional dose administration requires washing, plating and reconstituting the cells the before they are administered to a patient.

Getting rid of the prior day dose prep is one example of the maturation of the field, which we are deploying today to help usher in a new branch of medicine, Culley said.

At Lineage, were tackling problems that largely were intractable. For dry AMD, theres nothing approved by the FDA. No one know why the retinal cells die off, so we manufacture brand new retinal cells (OpRegen) and implant them, Culley said. Were seeing very encouraging clinical signs, including the first-ever case of retinal restoration.

Retinal cells compose a thin layer in the back of the eye, Culley explained.

They start to die off in one spot, and that area grows outward. When we inject our manufactured cells where the old ones died, weve seen the damaged area shrink and the architecture in previously damage areas completely restored, Culley said. Weve treated 20 patients for dry AMD in, ostensibly, safety trials, but you cant help but notice efficacy when a patient reads five more lines on an eye chart. Its hard to imagine our intervention wasnt responsible for that, especially when humans cant regenerate retinal tissue.

The spinal injury program (OPC1) may represent an even greater breakthrough. As with dry AMD, there is no FDA-approved therapy.

We manufacture oligodendrocytes and transport them into the spinal cord, to help produce the myelin coating for axons, he told BioSpace. Because of the oligodendrocytes, the axons grow, become myelinated, and begin to function. Small molecule and antibody therapies havent been able to do that.

So far, 25 people have been treated in a Phase I/II trial. Culley reported cases in which a quadriplegic man, after OPC1 therapy, is now typing 30 to 40 words per minute, and another who now can throw a baseball. Its not unusual for patients who initially were completely paralyzed to now schedule their treatments around college classes, Culley said.

Humans can have varying degrees of recovery from spinal cord injury, but these are higher than we would expect, Culley said.

Other cell and gene companies are advancing solutions, too.

Many companies with induced pluripotent stem cells (iPSCs) are trying to figure out how to get scalability, purity, and reproducibility to work for them. Its not a quick fix, he said.

One of the challenges is balancing the clinical and manufacturing aspects of development.

If you have a technology thats not yet commercially viable, but you have clinical evidence, its tempting to focus on the clinical side, Culley said.

Too many companies do that, and then find their candidate must be reworked for scale up. Therefore, consider scale up and manufacturing early.

Theres a need for balance at a more granular level, too. For example, he asked, How many release criteria do you need? Just because you know a cell expresses a certain surface marker, does that add to your process? Ive seen companies ruined by trying to be perfect, and others by rushing headlong, seeing evidence where evidence doesnt exist.

As Lineage matures its processes to support larger clinical trials, the greatest challenges have been time It takes 30 to 40 days to grow cells, Culley said and regulatory uncertainty. Often, there is no regulatory precedence so there are holes to be addressed. For example, cell and gene therapies sometimes have a delivery component such as a scaffold or delivery encapsulation technology that also must be considered. Real-time regulatory feedback isnt available, so you proceed, presuming that what youre doing will be acceptable to regulators.

The FDA recognizes that new, disruptive technologies and approaches are being used, and must be used, for cell and gene therapy to reach patients.

The FDA is responsive and is trying to push guidance out, Culley said, but it takes time.

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Disruptive Technologies and Mature Regulatory Environment Vital for Cell Therapy Maturation - BioSpace

Manufacturing a Personalized Cellular Universe: 3D Bioprinting in the Biotech Industry – BioSpace

Tissues in the body work as a complex team of interconnected cells. For instance, the heart is comprised of contractile cardiomyocytes, along with a vast array of endothelial cells, immune cells and fibroblasts. Similarly, the liver includes hepatocytes, immune cells, endothelial cells and epithelial cells. Put in all the cellular players, and the team wins. Take out one player, and the team is no longer able to sufficiently function.

The field of 3D bioprinting draws deeply on this idea of optimizing tissue regeneration and replacement. By using naturally-derived scaffolds, human cells and other biocompatible materials, 3D bioprinting has ushered in opportunities for researchers to design, print and optimize patient personalized tissues for purposes ranging from transplantation to drug testing.

The current drug development process is extremely lengthy and costly due to the lack of proper tools for preclinical drug screening, said Dr. Wei Zhu, CEO of Allegro 3D, a San Diego-based bioprinting company. What excites us most about 3D bioprinting is its potential to provide a paradigm shift in the drug discovery and screening process.

The bioprinting process is analogous to a Build-A-Bear factory but while a teddy bear contains carefully chosen ribbons, buttons and stuffing, 3D bioprinting creates complex tissues possibly derived from a patients own cells. In both cases, integrating customized components allows for layer-by-layer formation of something unique, yet fully functional.

While the techniques used for 3D bioprinting have mechanical grounding in traditional printing, the defining characteristic of 3D bioprinting is the usage of bioinks. Bioinks are complex, optimized mixtures of solution matrices containing carrier molecules and additional supporting agents. Often, the solution material is a biopolymer a naturally-derived gel, used to envelop the cells as a 3D molecular scaffold. Common biomaterials include gelatin, hyaluronic acid and alginate, all of which retain a high degree of biocompatibility. They provide a supporting structure, as well as a nurturing environment for future cellular growth and differentiation.

Historically, 3D bioprinting has become possible through three main modalities: light-based bioprinting, inkjet bioprinting and extrusion based bioprinting. Light-based bioprinting utilizes a light source, which can often be a blue LED, to cure photo-polymerizable bioinks into a more solidified scaffold. Inkjet bioprinting, on the other hand, is analogous to the conventional desktop printer, where bioink droplets are positioned on a receiving substrate based on computer control. Finally, extrusion based bioprinting relies on pressure to mechanically dispense bioinks by syringe extrusion onto receiving substrates.

Each technique has its own unique advantages. For example, light-based bioprinting allows for an incredible degree of precision, resolution and speed resulting in the possibility of micro or nanopatterning in a rapid fashion. Inkjet or droplet bioprinting is markedly straightforward, with low overall production costs and easy handling. Extrusion-based printing allows for printing with high cell densities.

Allegro 3D finds its niche in the bioprinting industry by providing light-based printing products primarily, their StemakerTMbioprinter and SteminkTMbioinks. Notably, the StemakerTMbioprinter was the worlds first digital light processing (DLP) bioprinter for high throughput tissue printing. Light is applied to the pre-polymer bioink, which photopolymerizes layer-by-layer to encapsulate live cells in the final 3D tissue construct. By using visible light as the photopolymerization source, cell viability remains very high during the manufacturing process. Furthermore, the technique allows for incorporation of various cell types in a single printed scaffold for instance, liver cells in the bottom layer, and endothelial cells in the top layer. With the ability to mix and match various cell types, the complexity and diversity of human tissues is an achievable possibility.

In terms of application, the possibilities of Allegro 3Ds bioprinting techniques have dramatic implications for the biomedical community.

With our StemakerTMbioprinters and SteminkTMbioinks, our customers can print 3D precision human tissues on demand for various biomedical applications, Zhu said. These applications include building tissue samples for disease modeling, providing patient-specific tissues or organs for therapeutic treatment of injuries, and providing 3D human tissues to investigate the toxicity and efficacy of new drug compounds in vitro.

By closely mimicking hepatic lobule structure through an eye-catching pattern of hexagons and circles that looks somewhat like a bees hive, this DLP bioprinter was able to print human liver tissue containing both human induced pluripotent derived stem cells and other supporting cells in seconds. The goal of such constructs would then be to provide easily accessible tissues for high-throughput drug discovery, or to print patient-derived hepatic tissues for liver regeneration.

According to Zhu, a key issue with traditional bioprinting techniques is that of scalability. Pharmaceutical and biotechnology industries often use high-throughput screening instruments for which the needs far exceed the capabilities of traditional bioprinters. The photopolymerization techniques of the StemakerTMbioprinter allow for compatibility with the high-throughput systems, which will greatly help our customers improve the accuracy and efficiency of drug screening and assay development.

On the extrusion-based bioprinting front, Allevi, a 3D bioprinting company based in Philadelphia, focuses on providing universally-friendly extrusion-based bioprinters, bioinks and software. Their latest model, named Allevi 3, contains three extruders through which bioinks can be deposited to form tissue scaffolds. Allevi also offers a wide selection of bioinks, which can be mixed in conjunction with cell populations to be directly utilized in their 3D bioprinters.

Likewise, Cellink, which was the first company to commercialize bioinks, is a Boston-based bioprinting company that has since expanded to provide services ranging from bioprinters to live cell imaging and liquid handling machines. Cellinks bioprinters include extrusion-based printers that contain up to six extruder heads with the BIO X6, as well as light-based printers. Their vast array of automated systems represents a diverse amalgamation of capabilities for more streamlined manufacturing.

Altogether, these 3D bioprinting companies represent a rapidly growing sector of the biotechnology industry. The unmet medical need of human tissue for regeneration, drug testing, and other pharmaceutical purposes remains a key driving force. 3D bioprinting has potential to change the ways in which we discover new, exciting chemical compounds to treat debilitating diseases, or to eliminate the strenuous waiting game experienced by many in need of an organ transplant. With the advent of these technologies, we acknowledge a future where we may potentially design, print and order complex human tissues for life-saving purposes.

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Manufacturing a Personalized Cellular Universe: 3D Bioprinting in the Biotech Industry - BioSpace

Fate Therapeutics Announces Presentations at the 2020 Society for Immunotherapy of Cancer Annual Meeting – GlobeNewswire

October 15, 2020 08:00 ET | Source: Fate Therapeutics, Inc.

SAN DIEGO, Oct. 15, 2020 (GLOBE NEWSWIRE) -- FateTherapeutics, Inc. (NASDAQ:FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for cancer and immune disorders, today announced that five abstracts for the Companys induced pluripotent stem cell (iPSC) product platform were accepted for presentation at the Society for Immunotherapy of Cancer (SITC) annual meeting being held virtually from November 9-14, 2020.

Accepted abstracts include clinical data from 15 patients in the dose-escalation stage of the Companys Phase 1 clinical trial of FT500 in advanced solid tumors (NCT03841110), which includes nine patients in Regimen A (three once-weekly doses of FT500 for up to two 30-day cycles as monotherapy) and six patients in Regimen B (three once-weekly doses of FT500 for up to two 30-day cycles in combination with checkpoint inhibitor therapy). The Company is currently enrolling the dose-expansion stage of the Phase 1 clinical trial for patients with non-small cell lung cancer or classical Hodgkin lymphoma who are refractory to, or have relapsed on, checkpoint inhibitor therapy. Each patient in the dose-expansion stage is to receive three once-weekly doses of FT500 at 300 million cells per dose, each with IL-2 cytokine support, for up to two 30-day cycles in combination with the same checkpoint inhibitor on which the patient failed or relapsed.

Oral Presentation

Poster Presentations

All abstracts are scheduled to be available on the SITC website on November 9, 2020.

About Fate Therapeutics iPSC Product Platform The Companys proprietary induced pluripotent stem cell (iPSC) product platform enables mass production of off-the-shelf, engineered, homogeneous cell products that can be administered with multiple doses to deliver more effective pharmacologic activity, including in combination with other cancer treatments. Human iPSCs possess the unique dual properties of unlimited self-renewal and differentiation potential into all cell types of the body. The Companys first-of-kind approach involves engineering human iPSCs in a one-time genetic modification event and selecting a single engineered iPSC for maintenance as a clonal master iPSC line. Analogous to master cell lines used to manufacture biopharmaceutical drug products such as monoclonal antibodies, clonal master iPSC lines are a renewable source for manufacturing cell therapy products which are well-defined and uniform in composition, can be mass produced at significant scale in a cost-effective manner, and can be delivered off-the-shelf for patient treatment. As a result, the Companys platform is uniquely capable of overcoming numerous limitations associated with the production of cell therapies using patient- or donor-sourced cells, which is logistically complex and expensive and is subject to batch-to-batch and cell-to-cell variability that can affect clinical safety and efficacy. Fate Therapeutics iPSC product platform is supported by an intellectual property portfolio of over 300 issued patents and 150 pending patent applications.

About FT500 FT500 is an investigational, universal, off-the-shelf natural killer (NK) cell cancer immunotherapy derived from a clonal master induced pluripotent stem cell (iPSC) line. The product candidate is being investigated in an open-label, multi-dose Phase 1 clinical trial for the treatment of advanced solid tumors (NCT03841110). The study is designed to assess the safety and tolerability of FT500 as a monotherapy and in combination with one of three FDA-approved immune checkpoint inhibitor (ICI) therapies nivolumab, pembrolizumab or atezolizumab in patients that have failed prior ICI therapy. Despite the clinical benefit conferred by approved ICI therapy against a variety of tumor types, these therapies are not curative and, in most cases, patients either fail to respond or their disease progresses on these agents. One common mechanism of resistance to ICI therapy is associated with loss-of-function mutations in genes critical for antigen presentation. A potential strategy to overcome resistance is through the administration of allogeneic NK cells, which have the inherent capability to recognize and directly kill tumor cells with these mutations.

About Fate Therapeutics, Inc. Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for cancer and immune disorders. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Companys immuno-oncology product candidates include natural killer (NK) cell and T-cell cancer immunotherapies, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens with chimeric antigen receptors (CARs). The Companys immuno-regulatory product candidates include ProTmune, a pharmacologically modulated, donor cell graft that is currently being evaluated in a Phase 2 clinical trial for the prevention of graft-versus-host disease, and a myeloid-derived suppressor cell immunotherapy for promoting immune tolerance in patients with immune disorders. Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit http://www.fatetherapeutics.com.

Forward-Looking Statements This release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 including statements regarding the advancement of, plans related to, and the therapeutic potential of the Company's product candidates, the Companys clinical development strategy and plans for the clinical investigation of its product candidates, and the Companys preclinical research and development programs. These and any other forward-looking statements in this release are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk of difficulties or delay in the initiation of any planned clinical studies, or in the enrollment or evaluation of subjects in any future clinical studies, the risk that the Company may cease or delay preclinical or clinical development of any of its product candidates for a variety of reasons (including requirements that may be imposed by regulatory authorities on the initiation or conduct of clinical trials or to support regulatory approval, difficulties in manufacturing or supplying the Companys product candidates for clinical testing, and any adverse events or other negative results that may be observed during preclinical or clinical development), the risk that results observed in preclinical studies of the Companys product candidates may not be replicated in ongoing or future clinical trials or studies, and the risk that the Companys product candidates may not produce therapeutic benefits or may cause other unanticipated adverse effects. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the Companys actual results to differ from those contained in the forward-looking statements, see the risks and uncertainties detailed in the Companys periodic filings with the Securities and Exchange Commission, including but not limited to the Companys most recently filed periodic report, and from time to time in the Companys press releases and other investor communications.Fate Therapeutics is providing the information in this release as of this date and does not undertake any obligation to update any forward-looking statements contained in this release as a result of new information, future events or otherwise.

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Fate Therapeutics Announces Presentations at the 2020 Society for Immunotherapy of Cancer Annual Meeting - GlobeNewswire

Global Stem Cell Therapy Market 2020: Trends, and Opportunity Analysis, Top Manufacturers And Forecast to 2027 – PRnews Leader

Reportspedia has recently come up with a new market research report titled, Stem Cell Therapy Market. This statistical market study compromises an extensive understanding of the present-day and impending stages of the industry market based on factors such as major research skills, management schemes, drivers, restraints, opportunities, challenges, and visions include the subdivisions in the industries and regional distribution. Besides, this report emphasizes the latest events such as technological developments and product launches and their consequences on the Market. The research report delivers the global market revenue, parent market trends along with market attractiveness per market segment.

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Celgene Corporation Osiris Therapeutics, Inc. Pharmicell Co., Ltd MEDIPOST Co., Ltd. Promethera Biosciences Fibrocell Science, Inc. Holostem Terapie Avanzate S.r.l. Cytori Therapeutics Nuvasive, Inc. RTI Surgical, Inc. Anterogen Co., Ltd. RTI Surgical, Inc

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The market specialists and researchers have done an all-encompassing breakdown of the global Stem Cell Therapy Market with the benefit of research methodologies such as PESTLE and Porters Five Forces analysis. They give precise and reliable market data and helpful recommendations with a means to support the players gain an insight into the overall current and upcoming market scenario. The report provides key statistics on the market status, size, share, growth factors of the Global Stem Cell Therapy industry.

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The main goals of the research report elegant the overall market overview on Stem Cell Therapy market dynamics, historic volume and value, newest and upcoming trends, Porters Five Forces Analysis, cost structure, government policies, and regulations, etc.

KEY MARKET SEGMENTS

On the basis of types, the Stem Cell Therapy Market is primarily split into:

Adult Stem Cells Human Embryonic Induced Pluripotent Stem Cells Very Small Embryonic Like Stem Cells

On the basis of applications, the Stem Cell Therapy Market covers:

Regenerative Medicine Drug Discovery and Development

This research report represents a 360-degree overview of the competitive landscape of the Meat Ingredients Market. Likewise, it offers enormous data relating to current trends, technological advancements, tools, and methodologies. The Stem Cell Therapy report thoroughly upholds the up-to-date state of dynamic segmentation of the Stem Cell Therapy Industry, highlighting major and revenue efficient market segments comprising the application, type, technology, and the like that together coin lucrative business returns in the Stem Cell Therapy market.

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Table of Contents

Global Stem Cell Therapy Market Research Report

Chapter 1 Stem Cell Therapy Market Overview

Chapter 2 Global Economic Impact on Stem Cell Therapy

Chapter 3 Global Stem Cell Therapy Market Competition by Key Players

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Stem Cell Therapy Industry Analysis by Application, Type

Chapter 6 Stem Cell Therapy Market Manufacturing Cost Analysis

Chapter 7 Marketing Strategy Analysis, Distributors/Traders

Chapter 9 Market Effect Factors Analysis

Chapter 9 Global Stem Cell Therapy Market Forecast

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Global Stem Cell Therapy Market 2020: Trends, and Opportunity Analysis, Top Manufacturers And Forecast to 2027 - PRnews Leader