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Abu Dhabi Stem Cells Centre collaborating with Israeli firm for COVID-19 therapies – Gulf News

A medical staff member carries a swab sample for testing at a screening centre in Abu Dhabi.

Abu Dhabi: UAE's Abu Dhabi Stem Cells Centre (ADSCC) is collaborating with Israeli regenerative medicine company, Pluristem, to advance COVID-19 therapies.

In a statement, ADSCC said it was working to administer Pluristem developed PLX cells via a nebuliser to COVID-19 patients. The collaboration will allow ADSCC to expand its stem cell therapy options with the novel PLX cells, while also enabling Pluristem to leverage the ADSCCs nebuliser administration experience to develop a new treatment delivery model for PLX cells.

ADSCC has reported effective usage of nebulisers to treat patients suffering from COVID-19 infection, with stem cells sourced from the patients own blood.

Further discussions are also ongoing to treat chronic Graft Versus Host Disease (cGvHD) a life-threatening immune response to the donors stem cells against the host (patient).

Both projects follow a recently-signed agreement between ADSCC and Pluristem to harness the power of regenerative medicine.

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Abu Dhabi Stem Cells Centre collaborating with Israeli firm for COVID-19 therapies - Gulf News

Majority of Respondents Support Chimeric Animal Research: Survey – The Scientist

Human-animal chimeric embryosorganisms created using cells from two or more specieshave the potential to change how researchers study disease and generate organs and tissues for human transplants. One day, scientists have proposed, it may be possible for someone with, say, pancreatic cancer to have their stem cells injected into a modified swine embryo lacking its own pancreas so it can grow the human organ for donation.

Already, human-animal chimeric embryos (HACEs) have been created using human cells injected into pigs, sheep, mice, rats, and monkeys, although none in the US have been brought to term. In fact, their very existence is ethically contentious. What happens, for example, if scientists were to grow a human brain in an animal, blurring the line between species?

In response to ethical, social, and legal concerns, the National Institutes of Health (NIH) issued a moratorium on funding for HACE research in 2015 pending the development of a new set of regulatory guidelines. While research continues in other countriesand even in the US, through collaborations with foreign researchers and private fundingthe NIH has yet to reverse its decision, despite previous announcements that it would do so.

To gauge the American publics support for HACE research, Francis Shen, a professor of law at the University of Minnesota, recreated two recent surveys carried out in Japan, where many of the worlds HACE studies are done. In those surveys, Shens colleagues found that the majority of the Japanese public supported the use of HACEs, although their feelings varied depending on the type of organ or tissue being grown. We thought, Boy, itd be really interesting to see if the American public thinks about things the same way, Shen tells The Scientist.

Shens team directly translated the Japanese surveys into English, asking 430 participants to rate their support for each of the three steps involved in producing an organ using HACE technology: the insertion of human stem cells into an animal embryo, the transplanting of the embryo into a surrogate, and the harvesting of the resulting organ for use in a human. As before, they gauged peoples reactions to organ and tissue types, including skin, liver, blood, heart, brain, and gametes.

The Scientistspoke with Shen about the results of the US study, published today (October 1) in Stem Cell Reports.

University of Minnesota Law School

Francis Shen:Organ transplantation is a major goal, and that would be a major breakthrough. When I describe [HACEs] to . . . colleagues who maybe havent heard of them before, I talk about organ transplantation. And they understand that, yes, if you grow an organ from your own cells, it makes intuitive sense that your body might be more receptive.

I think there are also a large number of applications that fall broadly under regenerative medicine. One is to better understand the mechanisms of disease and organ function. Theres basic science advances to be achieved there. And then there are applied clinical advances and improvements in treatment across a wide range of diseases and disorders. We can develop better interventions, pharmacological and otherwise. The techniques are not just about improving organ donation. There are also a number of ways, through both basic and applied science, this work can really improve our knowledge and therefore response to any number of diseases and disorders.

FS: One of the main findings was that there seems to be very broad support, even broader than in the Japanese public, for the different steps of HACE research. Support was 59 percent, so a strong majority, support all three steps, including the returning of the organ into a human.

Second was that there are some differences across subgroups in the public. One thing that we thought was interesting is that, although lower, in some instances the support of those who are politically conservative was still quite strong . . . suggesting that this type of stem cell researchusing [induced pluripotent stem] cells and not embryonic stem cells harvested from a fetusperhaps could be more politically palatable.

FS:[People are] more accepting of using HACEs to grow things like livers and skin than sperm, eggs, or brains, and I think it gets to humanization. Its speculation, but I think its informed speculation based on other ethical scholarship and work that has been done. A liver is kind of a liver, it doesnt seem to have too many special properties, but the sperm and the egg and the brain, those are part and parcel of a person. So it feels much more ethically concerning to grow a person in a pig, as opposed to growing just some constituent part of a person.

Someone has a heart transplant or a liver transplant, and it just kind of seems to make more sense. I think theres a cultural acceptance and understanding thats easier to analogize to.

There are a series of ethical concerns, and we tried pretty hard in the paper to emphasize that. They include animal welfare, human dignity, and then the potential for the neurological humanization of chimeric animals.

I think addressing them is tremendously important. Although the NIH has a moratorium presently, it doesnt mean this type of research isnt going to happen. If the NIH doesnt fund it with these ethical guidelines in place, it could be funded and produced elsewhere outside of NIH purview. So not only is there an opportunity to set the ethics frameworks here, theres almost an imperative to do so.

The bottom line for me is that the ethics and the laws and regulation should go hand in hand with the development of the research. And to do that productively means we need to get together and work through these complicated issues. What our study suggests is that the American public would like us to do that.

Editors note: The interview was edited for brevity.

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Majority of Respondents Support Chimeric Animal Research: Survey - The Scientist

Dust off the crystal ball: It’s time for STAT’s 2020 Nobel Prize predictions – STAT

The mistake Nobel Prize prognosticators yours truly included make is to look through the greatest hits of biochemistry, biology, and medicine (the areas STAT covers) nuclear hormone receptors! microRNAs! and figure (as last years prediction story did) one of those is due and deserving. The trouble is, as MITs Phillip Sharp, who shared the 1993 medicine Nobel, told me, There is just a lot of good science that will never get recognized.

So focusing on the greatest hits to forecast the science winners who will be announced next week is too simplistic. Theyre all contenders, but the smart money looks for other criteria. Like toggling between discoveries of what cells and molecules do and inventions of techniques that reveal what they do, or between disciplines, or (for medicine) between something that directly cures patients and something about the wonders of living cells.

By that criteria, it might be a techniques turn, since the last such winner in medicine was for turning adult cells into stem cells, in 2012. Could this be the year for optogenetics, which allows brain scientists to control genetically modified neurons with light? I dont think optogenetics has made a big enough impact outside of neuroscience yet, said cancer biologist Jason Sheltzer of Cold Spring Harbor Laboratory, who dabbles in Nobel predictions, but who knows.

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The last Nobel for DNA sequencing was way back in 1980, he pointed out, and since then we have seen the complete sequencing of the human genome, one of humanitys towering achievements. (Sheltzer correctly predicted 2018s medicine Nobel for immuno-oncology pioneer James Allison. The Human Genome Project could win it for the officials who led it, like Francis Collins of the National Institutes of Health and Eric Lander of the Broad Institute. Would Craig Venter, who led a competing private effort, make it to Stockholm, too? Let the betting commence!

Just to be clear, science Nobels arent chosen all that, well, scientifically. For medicine, a five-member Nobel Committee for Physiology or Medicine at Swedens Karolinska Institute sifts nominations and selects candidates. The 50-member Nobel Assembly votes, this year on Oct. 5. So you can get head-scratchers from, say, 20-18-12 or similarly split votes if, say, genetics fanciers split their votes among two contenders. (If you want to know if that happened, hang on until 2070: Nobel records are secret and sealed for 50 years.) For chemistry, chosen on Oct. 7 this year, the five-member Nobel Committee of the Royal Swedish Academy of Sciences likewise sifts nominations and recommends finalists to the academy for a vote.

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Besides invention and discovery switching off in the medicine Nobel, there certainly seems to be periodicity in terms of disciplines taking turns, said David Pendlebury of data company Clarivate Analytics. He has made 54 correct Nobel predictions (usually in the wrong year, but in 29 cases within just two) since 2002 by analyzing how often a scientists key papers are cited by peers and awarded predictive prizes like the Lasker or Gairdner awards.

Neuroscience won the medicine Nobel in 2000, 2004, 2014, and 2017, immunology in 2008, 2011, and 2018, for instance. Infectious disease and cancer win every decade or two, and so are probably also-rans for 2020. Thats why STAT said last year that the 2018 medicine award for immuno-oncology made cancer an unlikely 2019 winner. Yet William Kaelin, Peter Ratcliffe, and Gregg Semenza won for discovering how cells sense and adapt to oxygen availability, through gene regulation, which is tangentially related to cancer. Go figure.

For the medicine prize, periodicity also applies to toggling between super-basic molecular biology and stuff that actually cures people (not year by year, but generally). Last years award for how cells sense changing oxygen levels was pretty abstruse and might shape this years choice.

Prizes with a more clinical focus have been 2003 (MRI), 2005 (H. pylori and ulcers), 2008 (HIV), 2015 (roundworm and malaria therapy), and 2018 (immuno-oncology), [so] maybe a clinical type of prize this year, [such as] hepatitis C treatment, brain stimulation for Parkinsons, cochlear implant, statins Pendlebury said. We wouldnt be surprised at a hep C win for Charles Rice of Rockefeller University and Ralf Bartenschlager of Heidelberg University (2016 Lasker winners) for the super-basic discoveries that led to drugs that cure the viral disease.

Like Pendlebury, Sheltzer believes in predictive prizes. I looked back at the last 20 years of Nobel Prizes in medicine/physiology, he said. Eighty-three percent of them had won at least one of three prizes before the Nobel: the Lasker, the Gairdner, or the Horwitz Prize. Of the five people who have recently won all three, only one works in a field so far ignored by the Nobel committees, he said: Yale School of Medicines Arthur Horwich, a pioneer of protein folding and chaperone proteins. In addition to the Gairdner in 2004, Horwitz in 2008, and Lasker in 2011, he received the $3 million Breakthrough Prize in 2019. So thats guess #1, Sheltzer said.

Unless Weve had a few [medicine] awards that you could classify as cell biology recently oxygen sensing in 2019, autophagy in 2016, even immune regulation is kinda cell biological, Sheltzer acknowledged. So I think a genetics award is more likely than one to Horwich, whose discoveries about how cells fold the proteins they synthesize are central to the understanding of life. STATs nickel says look no further than the 2015 Lasker Basic Medical Research Award: It honored Evelyn Witkin of Rutgers and Stephen Elledge of Harvard for discovering how DNA repairs itself after being damaged.

Might David Allis of Rockefeller and Michael Grunstein of UCLA finally get the call to Stockholm? They discovered one way genes are activated (through proteins called histones). Theyve shared a 2018 Lasker and a 2016 Gruber Prize in Genetics, and basically launched the hot field of epigenetics. I think a prize related to epigenetic control of transcription by DNA and histone modifications could be in order, Kaelin told STAT.

For physiology or medicine, Pendlebury likes Pamela Bjorkman of Caltech and Jack Strominger of Harvard for determining the structure and function of major histocompatibility complex (MHC) proteins, a landmark discovery that has contributed to drug and vaccine development, as well as Yusuke Nakamura of the University of Tokyo for genome-wide association studies that led to personalized approaches to cancer treatment (personally, we doubt this is cancers year again), and Huda Zoghbi of Baylor College of Medicine for work on the origin of neurological disorders.

In chemistry, Pendlebury likes Moungi Bawendi of MIT, Christopher Murray of the University of Pennsylvania, and Taeghwan Hyeon of Seoul National University for synthesizing nanocrystals, a cool new way to deliver drugs, and Makoto Fujita of the University of Tokyo for discovering supramolecular chemistry, in which lab-made molecules self-assemble by emulating how nature makes them. That has some overlap with Frances Arnolds 2018 Nobel for chemistry, so were skeptical, but who knows?

Lets address the elephant in the Nobel anteroom, and the chatter that the revolutionary genome editing technique CRISPR will win for chemistry. (Its value in medicine is still TBD, but its stellar biochemistry.)

The discovery of the CRISPR-Cas9 system is certainly worthy of a Nobel Prize, Kaelin said. I suspect the challenge here will be to get the attribution right. Perhaps there could be a chemistry prize for the basic mechanism and a medicine prize for application to somatic gene editing in human cells.

By attribution, he means, who gets CRISPR credit? Only three people can share a Nobel. But CRISPR has more mothers and fathers than that. Jennifer Doudna of the University of California, Berkeley, and her collaborator Emmanuelle Charpentier have won a slew of predictive prizes for their work turning a bacterial immune system into a DNA editor, but dark horse Virginijus iknys of Vilnius University shared the 2018 $1 million Kavli Prize in nanoscience for his CRISPR work. And Feng Zhang of the Broad Institute is more widely cited than the above three, Pendlebury said, a marker of what colleagues think.

CRISPR citations built up more to Feng Zheng et al. than to Doudna and Charpentier, but I dont think that matters as much as judgments about priority claim, Pendlebury said. There are more than three to credit and I do think that is problematic. Bad feelings are not something the Nobel Assembly wants to generate, I am sure.

CRISPR will win, said CSHLs Sheltzer. Its a question of when, not if. Zhang/Doudna/Charpentier/Horvath/Barrangou shared the Gairdner. Pick 2 or 3 of them?

Senior Writer, Science and Discovery

Sharon covers science and discovery.

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Dust off the crystal ball: It's time for STAT's 2020 Nobel Prize predictions - STAT

BrainStorm Cell Therapeutics to Announce Third Quarter Financial Results and Provide a Corporate Upd – PharmiWeb.com

NEW YORK, Oct. 2, 2020 /PRNewswire/ --BrainStorm-Cell Therapeutics Inc. (NASDAQ: BCLI), a leader in developing innovative autologous cellular therapies for highly debilitating neurodegenerative diseases, announced today that the Company will hold a conference call to update shareholders on financial results for the third quarter ended September 30, 2020, and provide a corporate update, at 8:00 a.m., Eastern Daylight Time (EDT), on October 15, 2020.

BrainStorm's CEO, Chaim Lebovits, will present a corporate update, after which, participant questions will be answered. Joining Mr. Lebovits to answer investment community questions will be Ralph Kern, MD, MHSc, President and Chief Medical Officer, David Setboun, PharmD, MBA, Executive Vice President and Chief Operating Officer, and Preetam Shah, PhD, MBA, Executive Vice President and Chief Financial Officer.

Participants are encouraged to submit their questions prior to the call by sending them to:q@brainstorm-cell.com. Questions should be submitted by5:00 p.m. EDT,Tuesday, October 13, 2020.

Teleconference Details BRAINSTORM CELL THERAPEUTICS 3Q 2020

The investment community may participate in the conference call by dialing the following numbers:

Participant Numbers:

Toll Free: 877-407-9205 International: 201-689-8054

Those interested in listening to the conference call live via the internet may do so by visiting the "Investors & Media" page of BrainStorm's website atwww.ir.brainstorm-cell.comand clicking on the conference call link.

Event Link: Webcast URL: https://bit.ly/30pVpNG Webcast Replay Expiration: Friday, October 15, 2021

Those that wish to listen to the replay of the conference call can do so by dialing the numbers below. The replay will be available for 14 days.

Replay Number:

Toll Free: 877-481-4010 International: 919-882-2331 Replay Passcode: 37811

Teleconference Replay Expiration:

Thursday, October 29, 2020

About NurOwn

NurOwn (autologous MSC-NTF) cells represent a promising investigational therapeutic approach to targeting disease pathways important in neurodegenerative disorders. MSC-NTF cells are produced from autologous, bone marrow-derived mesenchymal stem cells (MSCs) that have been expanded and differentiated ex vivo. MSCs are converted into MSC-NTF cells by growing them under patented conditions that induce the cells to secrete high levels of neurotrophic factors (NTFs). Autologous MSC-NTF cells can effectively deliver multiple NTFs and immunomodulatory cytokines directly to the site of damage to elicit a desired biological effect and ultimately slow or stabilize disease progression. BrainStorm has fully enrolled a Phase 3 pivotal trial of autologous MSC-NTF cells for the treatment of amyotrophic lateral sclerosis (ALS). BrainStorm also recently received acceptance from theU.S. Food and Drug Administration(FDA) to initiate a Phase 2 open-label multicenter trial in progressive multiple sclerosis (MS) and initiated enrollment inMarch 2019.

AboutBrainStorm Cell Therapeutics Inc.

BrainStorm Cell Therapeutics Inc.is a leading developer of innovative autologous adult stem cell therapeutics for debilitating neurodegenerative diseases. The Company holds the rights to clinical development and commercialization of the NurOwn technology platform used to produce autologous MSC-NTF cells through an exclusive, worldwide licensing agreement. Autologous MSC-NTF cells have received Orphan Drug status designation from theU.S. Food and Drug Administration(FDA) and theEuropean Medicines Agency(EMA) for the treatment of amyotrophic lateral sclerosis (ALS). BrainStorm has fully enrolled a Phase 3 pivotal trial in ALS (NCT03280056), investigating repeat-administration of autologous MSC-NTF cells at sixU.S.sites supported by a grant from theCalifornia Institute for Regenerative Medicine(CIRM CLIN2-0989). The pivotal study is intended to support a filing forU.S.FDA approval of autologous MSC-NTF cells in ALS. BrainStorm also recently receivedU.S.FDA clearance to initiate a Phase 2 open-label multicenter trial in progressive multiple sclerosis (MS). The Phase 2 study of autologous MSC-NTF cells in patients with progressive MS (NCT03799718) started enrollment inMarch 2019. For more information, visit the company's website atwww.brainstorm-cell.com.

ContactsInvestor Relations: Corey Davis, Ph.D. LifeSci Advisors, LLC Phone: +1 646-465-1138 cdavis@lifesciadvisors.com

Media:Paul Tyahla SmithSolve Phone: + 1.973.713.3768 Paul.tyahla@smithsolve.com

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SOURCE Brainstorm Cell Therapeutics Inc

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BrainStorm Cell Therapeutics to Announce Third Quarter Financial Results and Provide a Corporate Upd - PharmiWeb.com

Different Types of Childhood Cancer | INTEGRIS – Integris

If youre a parent, you know the thoughts, feelings and emotions that come with protecting your child. Youd do anything for them to ensure they live a long, healthy life. But what will you do when there are times when health conditions, such as childhood cancer, stand in the way?

Cancer in children is more common than you may think, as it accounts for the second-leading cause of death behind accidents. While a cancer diagnosis, or even the thought of your child developing cancer one day, is overwhelming, modern medicine has improved survival rates. As with any cancer, early detection is key. To help you familiarize yourself with childhood cancer, we asked Michael Confer, M.D., a radiation oncologist at the INTEGRIS Cancer Institute, about the different types of cancers, which signs to look for and how they can be treated.

Unlike adult cancers, which can result from the environment or exposure to certain things, childhood cancers result from genetic mutations that occur early on in life or before birth.

It all comes down to changes in genes. Your DNA contains information to make different types of cells in your body. In other words, your skin cells contain information to be brain cells, while your kidney cells contain information to be heart muscle cells. As cells mature, they become specialized, turning on and off certain genes to allow them to perform specific duties. Cells need to be able to replicate to replace damaged cells of the same category. They grow with help from genes called proto-oncogenes.

When your DNA changes, it leads to genetic mutations, and cells can become permanently activated. This can lead to cells duplicating uncontrollably, known as cancer.

Tumor suppressor genes slow down cell division. They repair DNA mistakes before cells divide and control cells internal death process (apoptosis or programmed cell death), Dr. Confer says. DNA mutations within tumor suppressor genes can also allow cells to duplicate uncontrollably. Children can be born with mutated proto-oncogenes or tumor suppressor genes in certain cells. These abnormally programmed cells lead to most childhood cancers.

So, what causes DNA changes? Your child can inherit genes from a parent that increases their risk of cancer or they can acquire these genes. Cancers from acquired, sporadic gene mutations are more common than those from inherited gene mutations 5% of all childhood cancers come from inherited mutations.

Breast cancer and ovarian cancer are the most common types of cancer caused by inherited DNA changes from BRCA1 or BRCA2 gene mutations. Even with how well-known these are, only 5 to 10% of breast cancer cases come from BRCA1/BRCA2 inherited mutations. Plus, breast cancer and ovarian cancer are more common in adults than children. Talk to your doctor or visit a genetic counselor if you have specific questions about inherited mutations.

Cancer can impact any part of your body, ranging from your bones and blood cells to your brain, spinal cord and other internal organs. You may be most familiar with leukemia, lymphoma, and brain and spinal tumors, since they are the most common. But, here is a full overview of cancers that commonly affect children, according to the American Cancer Society.

Leukemia: This is the most common type of cancer in children, accounting for 28% of cases. It generally starts in white blood cells and becomes fast growing (acute). Acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML) are the two most common types of leukemia. Three out of every four children with leukemia have ALL. This type of cancer starts in the lymphoid cells, called lymphocytes, whereas AML starts in myeloid cells. Chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL) are two types of rare cancers

Brain and spinal cord tumors: These types of cancers make up 26% of all cases. Brain tumors are more common than spinal cord tumors. The cancer generally starts in the lower part of the brain.

Neuroblastoma: This type of cancer affects infants and young children. Neuroblastoma starts in nerve cells during pregnancy and accounts for 6% of childhood cancers. Abdomen swelling is a common sign of neuroblastoma.

Wilms tumor: This type of cancer starts in the kidneys and impacts children who are 3 or 4 years old. It accounts for 5% of childhood cancers.

Lymphoma: Although lymphoma isnt as common as other types of cancers, youve likely heard of Hodgkin lymphoma and non-Hodgkin lymphoma, the two main types of cancer that show up in the lymphocytes. Non-Hodgkin lymphoma (accounts for 5% of childhood cancers) appears in younger children and is more common than Hodgkin lymphoma (accounts for 3%), which is more common in younger adults. You may notice a swollen lymph node under your childs arm or near their throat.

Rhabdomyosarcoma: This type of cancer develops in areas that your child uses to move their body, such as the head, pelvis, arms or legs. It accounts for 3% of childhood cancer cases.

Retinoblastoma: This cancer develops in the eyes, and your child is most at risk around the age of 2 until the age of 6. It accounts for 2% of childhood cancers.

Bone cancer: Bone cancer is more prominent in teens, but it still accounts for 3% of childhood cancers. There are two types, osteosarcoma and Ewing sarcoma, that show up via swelling around the bones. Ewing sarcoma is a less common type of cancer that is more prominent in older children and younger teens. Osteosarcoma, meanwhile, is more common in teens and in areas where bones grow quickly.

There isn't a one-size-fits-all guide to know if your child has cancer. In general, Dr. Confer says to keep an eye on any changes in your childs behavior, such as walking, eating, playing or sleeping. If theyre older, listen to any complaints they may have. Some cancers may produce a lump or swelling and pain in certain areas. Other symptoms include a loss of energy, weight loss, sudden eye or vision changes, frequent headaches with vomiting or a persistent fever that signifies the body is fighting an infection.

For example, leukemia, the most common type of childhood cancer, affects most children between the ages of 2 and 4. Typical symptoms include fever, bleeding, deep pain in the bones, small red spots on the skin called petechiae, bruises and enlarged lymph nodes.

Notify your childs pediatrician if any of these concerns arise. Aside from that, you should schedule your child for routine checkups and wellness visits.

Routine checkups and wellness visits help monitor normal growth and development. A good pediatrician-patient relationship helps the physician better identify subtle signs of cancer and gives parents a trusted sounding board for the concerns parents or children may have, Dr. Confer says.

Many childhood cancers have become increasingly treatable, leading to longer survival rates. Dr. Confer says acute lymphoblastic leukemia, lymphoma or kidney tumors known as Wilms tumor all have more than a 90% five-year survival rate (the percentage of patients who are alive five years after receiving treatment or a diagnosis).

In fact, the overall five-year survival rate for childhood cancers has improved from 58% in the mid-1970s to 84%, according to the American Cancer Society. But, certain types of aggressive cancer still exist. Diffuse intrinsic pontine glioma (DIPG), a rare brain tumor, is often cited as the childhood cancer with the poorest survival rate (less than 1% for five years).

No matter the diagnosis, continual hope and quality, proven therapies are the most important factors for children and families facing childhood cancers, Dr. Confer says.

Here are some of the most common forms of therapies to treat childhood cancer.

Surgery can help many patients, whether you need an entire tumor removed or a procedure to ease pain caused by a tumor. Your childs surgeon can also debulk a tumor, meaning they remove part of it and treat the rest with another method. Surgery has the highest success rate when its contained to one area, before the cancer has an opportunity to metastasize (spread to other parts of the body).

High doses of radiation help reduce cancer by either killing the cells or damaging their DNA to slow growth. Over time, these cells die and your body removes them. You can either receive internal or external radiation. External radiation comes from a beam that treats a specific body part, whereas internal radiation is in solid or liquid form. More specifically, brachytherapy is the medical term for solid internal radiation. Your doctor will place capsules, seeds or ribbons near the tumor. Systemic therapy is the medical term for liquid internal radiation. With this method, the radiation travels through your blood via a pill, injection or IV to kill cancer cells.

Chemotherapy comes in many methods of application, such as IV, oral, injection, topical or through a catheter, port or pump. Chemotherapy also kills healthy cells, which is one of the downsides. This is why many chemotherapy patients lose their hair and experience other side effects. Depending on the type and progression of the cancer, chemotherapy can help shrink a tumor to increase the success rate of surgery or radiation. Chemotherapy can also fight against any lingering cancer cells following surgery or radiation. Its also used to treat cancer that returns or metastasizes.

The immune system is your bodys way of defending itself against harmful germs, bacteria and viruses. When it comes to cancer, the immune system can have trouble recognizing and fighting off harmful cells because cancer starts in healthy cells. Immunotherapy helps your body pinpoint cancer kills to better defend against them. There are many types of immunotherapy treatments to boost your immune system. One type, chimeric antigen receptor (CAR) T-cell therapy, mixes your own T-cells with a virus that teaches the T-cells how to kill cancer cells.

Targeted therapy is a form of chemotherapy. But, as the name suggests, these drugs zero in on a specific area of the cancer cells. Depending on the drug, targeted therapy can change the protein levels in cancer cells or block chemical signals that help cancer cells grow. Other targeted therapy drugs can limit blood vessel production to cut off the cancer cells or distribute toxins to specifically kill the cancer while sparing healthy cells.

Stem cells, which originate in the bone marrow, make red blood cells, white blood cells and platelets. Leukemia and lymphoma start in the blood cells, causing damage to the cells your body needs to function. A stem cell transplant involves destroying cancer cells via chemotherapy and/or radiation before replacing them with new, healthy cells. This allows doctors to use stronger doses of chemotherapy or radiation knowing new cells, via a transplant, will replace old, damaged cells. Stem cell transplants can come from your own cells or the cells of another person. Donated cells are often more effective since they can help kill off cancer cells.

While you cant do anything to prevent your child from developing cancer, you can be proactive by scheduling regular checkups and looking out for warning signs and symptoms. Contact an INTEGRIS pediatrician if you have any concerns, and they can refer you to an oncologist at the INTEGRIS Cancer Institute.

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Different Types of Childhood Cancer | INTEGRIS - Integris

A perfect match: Bone marrow transplant saves twin brother’s life. Now their family pays it forward – 11Alive.com WXIA

When 5-year-old Sawyer was diagnosed with sickle cell at a young age, his fraternal twin, Saxton, turned out to be a perfect match.

ATLANTA This is not just a birthday party, its a celebration of second chances.

We are so blessed, said OShea Guillory. We want to share this.

It is also a commitment to help others, too.

Mikari Tarpley is 16. She is at the small birthday celebration and sang her heart out for 5-year-old Sawyer and his brother Saxton. She sings from a place of understanding.

She and Sawyer, her neighbor, have both been through a lot this year.

We found out about Sawyers sickle cell disease at a very early age, Guillory said. He was about three weeks old.

Sawyers mom said she was absolutely devastated. She refused to accept there was nothing she could do to help her son.

I did a ton of research," she said. I found an organization called Be The Match.

She discovered information about transplants that could be a potential cure. Doctors take stem cells from the bone marrow of a donor and transplant it into the recipient.

They just needed a donor.

It turns out Sawyer was born with his cure, Guillory said. His twin, Saxton, was a perfect sibling match.

Across the cul-de-sac, Mikari Tarpley, an actress, was fighting Hodgkins Lymphoma and finishing chemotherapy.

She knew Sawyer has been battling sickle cell. Theyd both lost their hair from treatment. She decided she wanted to use her Sweet 16th birthday to raise money for children like Sawyer.

We couldnt do much for my sixteenth because of COVID, so we thought it would be a great idea to do a fundraiser to help others, Mikari said.

She reached her goal of $16,000 to help children being treated for sickle cell disease at the Aflac Cancer and Blood Disorders Center.

Five-year-old Sawyer received a bone marrow transplant from his fraternal twin, Saxton. It was a success. Before long, Sawyer was riding a tricycle around Childrens Healthcare of Atlanta, racing his nurses and giggling along the way.

I truly have little warriors, Guillory said. My son, who helped save his brothers life - and my son - who was able to go through all of that and come out even stronger.

Now Sawyer, Saxton and their parents are spending their 5th birthday following Mikaris lead by paying it forward.

Sawyers mom OShea is starting a nonprofit, Sawyers Sickle Circle, to spread awareness and knowledge about sickle cell, Beads of Courage and Be the Match program. They launched a fundraiser on Sawyer and Saxtons birthday.

The Guillory family said the best present they could wish for is for other kids to have the chance to celebrate many more birthdays to come.

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A perfect match: Bone marrow transplant saves twin brother's life. Now their family pays it forward - 11Alive.com WXIA

Baby whose nosebleeds turned out to be deadly condition saved by stranger – Mirror Online

A baby whose nose bleed turned out to be a one-in-a-million disease has had his life saved by a complete stranger.

Tiny Daniel McAvoy's parents were told he would die unless he received the stem cell transplant before he turned two.

The infant was diagnosed with Wiskott-Aldrich syndrome, a rare blood disorder, when he was just ten weeks old.

Mum Georgie, 30, and dad Andrew, 37, noticed something wasnt right with their newborn when he suffered chronic nosebleeds and passed blood in his nappies.

But after desperately searching for the right donor for more than a year, Daniel has now had the transplant and is a smiley, happy tot back at home.

"Hes eating and playing and I really hope it continues that way. Im just so proud of him, hes done amazing," Georgie, of Benwick, Cambridgeshire, said today.

"There were plenty of times we thought he would die - we even had him christened in hospital because things werent looking great.

"He has the most severe level of the syndrome so from day one we were told he would need a transplant to replace his faulty immune system and defective cells and the procedure took place.

Doctors warned that he would go down quickly after the transplant but he hasnt and they're shocked."

When Daniel was first referred to hospital at three weeks old, medics first thought he had leukaemia, but after recovering from sepsis, he was discharged while they continued to look into the worrying case.

He was then rushed back to hospital at ten weeks old in July last year.

Georgie, who is a stay-at-home-mum, said: The nosebleeds went from nothing to doctors then telling us that he needed a bone marrow transplant to save his life.

He was diagnosed with Wiskott-Aldrich Syndrome in July 2019, which affects only one in a million boys and was the cause of the horrendous bleeds.

I never knew I was a carrier of the gene that causes it, so as a mum I felt pretty guilty that Id given him it."

The newborn woke up in May 2019 with a crust of blood on his nostril, which his parents thought was strange but a health visitor suggested it could be from a scratch.

But the tot began passing blood in vomit and nappies, and a GP then referred him to the hospital, where tests found he had a low platelet count that caused the bleeding.

Following a platelet transfusion to help stabilise him, Daniels parents were told he contracted sepsis but could also have meningitis and a rare type of leukaemia - so he was sent to a cancer ward.

Various procedures ruled out leukemia and out of nowhere the tiny tot began to get well again, so doctors discharged him.

Georgie added: Something still didnt sit right with me but some time later he had an unrelated hernia which needed an operation, and began having nose bleeds again.

I suggested that a doctor needed to look at the bigger picture because I knew there was something wrong with my baby.

The paediatrician looked back at all of Daniels notes and thought it was Wiskott-Aldrich Syndrome, which Id never heard of before, then after the operation to remove the hernia the haematologist agreed.

Within 24 hours of him being tested for this he was pretty much diagnosed and then doctors were speaking to us about bone marrow transplants - it all went very quickly.

In Daniels case, hes had a lot of bleeding problems - he bleeds from his gut, nose, eyes and mouth - so doctors were concerned about a catastrophic bleed that would kill him.

Wiskott-Aldrich Syndrome is a primary immunodeficiency which caused Daniels bleeding and left him prone to infections such as sepsis and also cancer.

He began having antibody infusions once a week as charities such as DKMS ran their global register to find a life-saving stem cell donor for Daniel, and a match was found in September 2019.

Georgie said: We had a terrifying 12 week wait but we were really fortunate that it was quick before a match was found.

His transplant then got delayed three times - the first and second times were because he wasnt well enough, and the third time was due to coronavirus.

I just went into panic mode because I thought he was going to die from this.

But Daniels transplant finally took place after a week-long chemo and immunotherapy course.

Were taking it day by day - if its successful, within two years he should be a healthy little boy.

Its all been a mixture of feelings - its really nice how hes so young that he wont remember how awful this all is but at the same time, sitting there watching your child have chemotherapy is the most heartbreaking thing in the world.

I would do anything to switch places with him.

Now that baby Daniel has been given another shot at life, his family are now calling out for others to join the transplant registers, as four out of ten patients arent lucky enough to get a match.

Georgie added: Its incredible how an anonymous donor saved Daniels life - without that person there would be no Daniel, they are all we needed to give him a second chance at life.

Its so simple and easy to sign up, and by doing so, you could save a babys life.

If you are aged between 17 and 55 and in general good health take the first step to register as a blood stem cell donor by registering for your home swab kit at http://www.dkms.org.uk.

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Baby whose nosebleeds turned out to be deadly condition saved by stranger - Mirror Online

Over 40 lakh people in Telangana have developed COVID-19 antibodies: Health Minister Eatala – The New Indian Express

By Express News Service

HYDERABAD:Health Minister Eatala Rajender on Friday said that around 40 lakh people in the State are estimated to have developed Covid-19 antibodies, according to information recently revealed by the Indian Council for Medical Research (ICMR) while announcing the results of its second round of sero survey conducted across the country.

That means that around 40 lakh people about 11 per cent of the States population have been affected by Covid-19 and cured of the disease, Eatala said while inaugurating the Stem Cell and Regenerative Medicine facility at NIMS Hospital in Hyderabad, which he said will prove to be a boon for poor cancer patients.

The facility will also help in bone marrow transplantation, he added. The Health Minister, who often criticises the ICMR for its handling of the Covid-19 crisis, on Friday blasted it for frequently changing its treatment guidelines.Telangana stuck to the claims it made during the start of pandemic on the approach taken to tackle the Covid-19 crisis, which he said have now been proved right.

Outpatient capacity to be increased at NIMS: Health Min

Earlier, Telangana said that convalescent plasma therapy is not very useful, costly medications such as Tocilizumab will not work and Remdesivirs usefulness will be limited. We had also said that treatments such as steroids will be good enough to treat Covid-19 patients. All these claims, backed by Gandhi Hospital doctors, have now come true, he said.

We had said that expenditure of `10,000 and quarantine is enough to provide Covid-19 treatment to patients with mild symptoms or those who are asymptomatic. ICU and oxygen beds will be required only for patients with severe symptoms, those with comorbidities or those who are poor and living in congested space. Even these claims have come true, he added.

Stressing that Covid-19 proves fatal in only limited cases, he said that now people would have to learn to live with Covid just the way they have learnt to live with seasonal ailments. Meanwhile, Eatala said that the outpatient consultation capacity at NIMS would be increased from 2,500 to 5,000 as the hospital was being provided `250 crore in the form of loan for construction of a new outpatient block along with a few critical care units. He also said that plans are being made on having separate entry and exit points at Gandhi Hospital for the treatment of non-Covid patients as hundreds of beds are lying unutilised. The Minister also said that the State government had planned to have four hospitals similar to NIMS, of which TIMS, Gachibowli, and AIIMS, Bibinagar, have materialised. A similar hospital is also being planned in Medchal-Shamirpet region, he added.

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Over 40 lakh people in Telangana have developed COVID-19 antibodies: Health Minister Eatala - The New Indian Express

How to Vote This November: A Progressive’s Opinion Redheaded Blackbelt – Redheaded Blackbelt

Every election Attorney Eric Kirk puts out a list of ballot recommendations. Here are his recommendations for our upcoming election.

Im getting these recommendations out a little early this time because you will be receiving your ballots in little over a week and I know that many of you will want to get your ballot in early to make sure it is counted, and so that it will be part of the election night count. Normally I like to wait until more of the other media and organizational endorsements come out so I can take their thoughts into account. And even when I do, once I send this thing out, I know that I will run into an article or someone will express thoughts to me which would change my analysis. Im pretty certain I will not change my intended vote on the Propositions though. If I do, I will follow up, but thats very unlikely at this point.

Thank you for your interest in my thoughts. Please contact me if you have any questions.

Proposition 14 Bond Funding of Stem Cell Research Yes

In 2004, in response to then President Bushs imposition of irrational restrictions of funding for research involving fetal stem cells, we passed Proposition 71 in response to limitations imposed on federally funded stem cell research. It established the California Institute for Regenerative Medicine which has funded over a thousand projects with about 70 institutions public and private leading to over 2500 peer-reviewed studies and thousands of clinical human trials. How productive has it been in bringing us closer to the promised miracle cures? I have read some criticisms which suggest that the successes have been overhyped and the advocates become very vague as to when, if ever, such treatments will become approved by all the appropriate agencies and start saving and improving lives by curing or mitigating such horrific diseases as Alzheimers, Parkinsons, spinal injuries, etc. Is it a boondoggle preying on false hope? I think thats a bit melodramatic. I wouldnt oppose more oversight even if it is purely informational. Im not a fan of the requirement of a 70 percent legislative supermajority to make changes in the law (though it is rare that a ballot proposition offers any such opportunity).

Proposition 14 would authorize the state to sell 5.5 billion in bonds and the payoff will be about 7.8 billion with interest. The funding is limited to about half-billion per year so it will stretch it out and maybe it will pay for itself again in all the above ways.

It will also specify that 1.5 billion to fund research and therapy for Alzheimers, Parkinsons, stroke, epilepsy, and other brain and central nervous system diseases and conditions.

Yes, there have been a number of ethics-challenged quacks pushing stem-cell snake oil, but thats not the Institutes fault. And the proposal doesnt prevent the state from cracking down on fraud, or educating the public as to the state of the science.

Opponents point to Obamas removal of Bushs research restrictions for federal funding and note that federal funding has resulted in about three times as many clinical studies as the California money. So far Trump has not restored the Bush restrictions, but it was reported in July that the President is stacking the federal ethics panel with anti-abortionists, and a vaccine in its third phase of clinical testing may be jeopardized not because its production involves fetal stem-cells, but because some of its research and development did and they oppose anything which is even merely the fruit of what they consider to be unethical research. Should Trump win a second term, that federal funding will probably be stopped.

The Prop 71 money is drying up although it generated 3 billion in matching funds (when Obama was in office) and created tens of thousands of jobs with benefits in terms of revenue and commerce (nearly 11 billion in stimulated economic activity). Im all for funding science, and if there are regulations or policies which can ensure the most productive results, then lets hear those proposals. Science is often and agonizingly slow process, but it is worth supporting regardless of how quickly utilitarian benefits arrive. We can do much worse with the money.

Proposition 15 Prop 13 Reform Yes!

This is probably one of the most important ballot measures we have had in a long time which represents a potential earthshaking break from the long impact of the tax revolt of 1978. We needed the reform as property values were taking huge leaps in certain parts of the state and counties wasted no time reassessing properties to increase their tax base. Working class people were in danger of losing their homes because they simply couldnt afford the increases in property taxes. It passed by a huge margin. Many progressives, including my parents, voted for it.

But it was an extreme measure which cost the state and local governments huge amounts of revenue and we watched our education system drop from the top five states in the country to the bottom ten within a decade as class sizes increased and education began to narrow towards an obsession with college prep at the expense of just about everything else even before the era of teaching to the test. I was in the eighth grade when it passed, and three of my favorite teachers were laid off. A really good science teacher went into hot tub sales. Fewer electives were available. And first responder systems as well as other infrastructure suffered, leading to a long string of bond issue initiatives to build one of the most ridiculously large prison systems in the world.

But you couldnt touch it. Even the mildest of reforms would be slapped down by the tax posse who had an iron grip on voters for this reason.

Among other things, Proposition 13 limited the assessment of real property to its purchase price rather than current market value. This means that if you dont sell your property or remodel it in certain ways which increase its value, you will not be reassessed and the taxes cannot be imposed at more than 1 percent of that value. Proposition 15 would exempt most commercial and industrial properties so that they will be assessed at current market value. The 1 percent rule would remain in effect. The measure would have no effect on agricultural land. And the increased revenues (estimates of 7 to 12 billion per year) would not be placed into the general fund, but into a special fund earmarked for local governments, special districts, and education (K-12 and community college).

I object to the latter part. We already have too many strings to all sorts of revenues so that the legislators are pretty much deprived of discretion when needs change from year to year. I have complained about this in the past. If we do not trust our legislators to exercise sound judgment as to spending then they shouldnt be in office.

On the other hand, it was local government and education which took the hardest hits under Proposition 13 to there is a certain logic to the earmarking.

There is some mitigation provided to protect small businesses who rent in the larger qualifying properties. The reassessments for properties of more than 50 percent of the space rented by small business will be deferred for five years. It also eliminates personal property taxes for small business and exempts up to $500,000 for larger businesses. Apparently, the hope is that this will offset increased rents.

If Proposition 13 had been introduced a decade later, there would have been competing measures less extreme as has taken place with other issues. Something like this measure might have been proposed to introduce a progressive tax element to the equation. It might have surpassed Howard Jarviss draconian measure. Homeowners needed a break. Maybe large commercial property owners didnt. And it may be that some large commercial property owners who arent dirt rich are going to have to make some tough choices. It may be that the measure discourages investment into a property which will significantly improve its value.

But it mitigates a serious revenue problem we have had for decades which has made our infrastructure and education system marginal.

There will be an intense opposition as the anti-tax folk will see any opening as a potential to lose it all. They want no precedent. Proposition 13 is practically a holy relic. But hopefully the worst aspects of it will become just that a relic.

Proposition 16 Restore Affirmative Action Yes with reservation

In 1996 voters passed Proposition 209 which effectively ended all affirmative action race considerations with regard to public university entrance and public contracts. The result was a huge drop in the presence of African Americans and Latinos on college campuses. Moreover, businesses owned by people of color and women lost contractual opportunities which some estimate to amount to a billion dollars per year.

You can say that such results are just because the missing students and business opportunities are based upon merit, but there have extensive discussions as to whether qualifications are more arbitrary than representative of intrinsic merit, and that the qualifications tend to be rigged towards a particular result. And maybe public university entrance should be based less on merit and more on individual and public benefit of the policy. These discussions are decades old and Im not going to rehash them here.

But the results of Prop 209 are clear, whether or not they are just. As of 2018, African Americans made up approximately 6% of the state population, but only 4% of undergraduate students in the UC system. Latinx students were 24.4% of UC students, but 39% of the state population. Of the UC students, 21% were white compared to 37% in California, and Asians were 33% of the UC undergraduate population compared to 15% in the state.

And this brings to the forefront a subject which has been the material for lawsuits Asians benefit the most from the lack of affirmative action and would be the most negatively impacted group by its return. Those of us who were raised in and around San Francisco are well aware of the controversies around the elite high school Lowell where Asians have been required under the quota rules to score higher on tests than other groups, including whites. For whatever reasons (which have been the subject of many research studies and analysis) Asian students tend to fare well with the entrance criteria. But if you arbitrarily exclude them, somehow, you risk very meritorious lawsuits from rejected white students who will argue that they are being hit from both sides of the equation.

I do support the goals of affirmative action and I hope that new policies can be developed which are effective and yet address the complexities.

I will close with an anecdote which almost turned me against affirmative action. I was a substitute teacher in San Francisco while I was in law school and I came to a very difficult placement. Some money had been allocated to hire a new English teacher to draw some students out of three very overcrowded English classes. In what I consider to have been a very bad administrative judgment each of three teachers was asked to name the students who should leave their classes and join the new classes. Naturally, at least two of the teachers sent all of their most challenging students. What they ended up with was four classes which were nearly unteachable. The teacher who had been hired quit within the first couple of weeks so the administration put out word for other English teachers to apply. The catch, under the policy the teacher had to be of color. I was told that there were a grand total of five or six non-white English teachers who were offered the job, but word got out from the substitute teachers and none of them wanted the job. There were white English instructors desperate enough for the job, but they couldnt be hired.

By the time I was assigned to the classes they were on their third sub and fourth teacher. Because I did not have an English certificate, I could only teach the class for 15 consecutive days then I could not be there for another few weeks. I was called back several times throughout the year and the classes were basically lost. Finally, they either broke or found a waiver to the rule and they hired a white teacher, who unfortunately had health problems and so was out of the classroom often. Whenever she was out, she had me called I took that as a great honor. And in fact, when I declined the placement one morning because I had law school exams to study for, I received a personal call from her literally begging me in tears to come in because if its anyone else I really cant come back. The last sub had the classroom telephone stolen it was later found above one of the removable tiles in the ceiling. Naturally I went in, but it was apparent to me that had there been continuity from the beginning of the year there maybe the year wouldnt have been lost for those kids. I dont know whether it was the policy itself or an administrative misconstruction which was responsible, but it failed those kids.

Assuming Proposition 16 passes I hope that the policy makers and administrators learn from the lessons which led to Proposition 209 and draw up some sound policies which benefit even white disadvantaged, because if it generates another backlash, we certainly wont get a third chance.

Proposition 17 Allow parolees to vote Yes

California does not have a felony exclusion rule for voting. And right now, anyone convicted can vote if they are on probation. However, someone on parole is still barred.

This is an easy one for me. I dont believe that the right to vote should be deprived for any reason other than a conviction for voter fraud. Prisoners should be allowed to vote.

Look. There is a slew of factors which are usually involved in the commission of a felony, depending on the nature of the crime. They include lack of empathy, lack of respect for rules, economic desperation, lack of self-restraint, momentary to long term lack of judgment, economic or other type of desperation, anger, sense of entitlement, self-centeredness, and many others sometimes in a complex combination to upset balances in the mess of human nature.

But one thing most felons have in common regardless of the motivation or impulse they experience life in alienation with society as a whole. In my experience very few who are prone to felonies bother to vote. Why? Because they dont see past themselves. Maybe they see as far as their immediate family, friends, and associates. Maybe.

A vote is a social act. An expression of connection to something larger than ones self. Larger than what one can see in their immediate social vicinity. To bother to vote you have to see what is not in your view. You have to feel connected. It makes no sense to deprive a felon of the right to vote. They probably dont even care.

If we are trying to rehabilitate, we want people to feel a stake in the society against which they have transgressed and be encouraged to engage with it. In fact, I might even support a measure which makes in-prison voting mandatory. What is the point of a punishment which reinforces the disconnect?

What is the down side to allowing them to vote? Do we have so many felons in prison and/or on parole that we are concerned about them coming together as a bloc to somehow vote in laws of criminality? Are we living in pre-Batman Gotham City? Seriously, I really dont see a downside. Even if they vote Republican, which is a possibility.

A law-and-order leftist friend of mine once told me that he viewed the act of crime as the ultimate right-wing act which in effect says, I want what I want and f anyone who gets in my way. I dont think its that simple, I see no logic in the deprivation of the vote. Its like punishing a child who snuck too many cookies by depriving them of the right to eat broccoli. Im not saying that voting is a cure for criminality. Im just saying that there is no logic to the deprivation.

So, the question of expanding the vote to parolees is a no-brainer. Yes. Of course.

Proposition 18 Expansion of Vote to Some 17-year-olds in Primaries Yes

Proposition 18 would allow a 17-year-old to vote in a primary if they will be 18 and eligible to vote in the general election which follows that primary. This is actually already in place in 18 other states and it makes sense. If you are going to vote in the general then you have a stake in who will be on the ballot in the general. And if they are engaged in the primary process, they are more likely to be informed come November. Makes sense to me. Youth engagement in politics is a perpetual challenge and in my opinion, though we do need to draw some lines, if theyre old enough to want to vote theyre probably mature enough.

Proposition 19 Senior Tax Break for Real Estate Speculation No

This proposal is not what it seems. Its actually kind of a jumbled mess. And it would be fiscally detrimental as well as potentially economically if it induces more real estate speculation.

Right now, some counties have a program which allows seniors over 55 (That makes me a senior. Weird.) to upgrade to a new home while holding on to the property tax amount of their prior home when purchasing another home within the same county or another participating county with reciprocation.

But why? Most people, of modest means, actually downsize when they get older and no longer have children and prefer to use the net equity to finance retirement or pass wealth on to heirs. If you are inclined to and can afford to buy a more expensive home, why shouldnt you pay the appropriate taxes for it? Because youre older? Proposition 13 was intended as a stop-gap measure to ensure that working class families would not lose their homes due to increasing tax burdens. Most voters who passed it did not envision it as a golden goose egg for which you could reap financial benefit in old age.

A very similar proposal was made a couple of years ago and I opposed it, as did about 60 percent of the voters. Ill just cut and paste what I wrote at the time.

It makes sense to make it easier to move, but this was written by Realtors with profit motive and isnt thought through in terms of fiscal impact or whether we really want to increase speculation and moving into larger homes at retirement. And it contains no caps on applicable home values. Elderly shouldnt be trapped in a home which may be far away from family, adequate medical care, etc., but the answer is to press for policies generating affordable housing for everyone. This is basically regressive and its kind of a new Prop 13 focusing most of its benefit towards rich baby-boomers.

Like the failed 2018 proposal, Proposition 19 once again puts no cap on increased home values, inviting speculation.

But the current measure even throws more weirdness into the mix.

It sets up a fund for the state to reimburse the counties for the loss of revenue of higher valued homes. Where does this money come from? Well, the proposal contains references to children of celebrities and evil east coast investors (I guess we dont have unethical investors here on the west coast). Basically it repeals aspects of Proposition 13 and 58 by cracking down on what is considered to be abuse of transfers from parents to adult children in which the children maintain the same assessed-value tax rates of the parents but rent the property out or hold onto it as a vacation home by requiring that the children live in the home to benefit from the tax rate (so I guess if you have multiple children all of them and their families or significant others should move into the house). Proposition 19 would limit the tax break to children who actually live in the home by requiring reassessment at market value rather than the parents purchase value. And even if you move into the home, youre limited in the tax break to the first million dollars. I mean, as Ive said I support serious reform proposals regarding Proposition 13 and even 58. But this is convoluted and will throw estate-planning for a few unnecessary loops.

Oh, and by the way it adds wildfires to the list of natural disasters for which a victim suffering a home loss could receive a tax break. And speaking of fires, 75 percent of the money will come out of the general fund to benefit firefighting this was thrown in at the last minute. 15 percent will go to reimburse counties for the loss of revenue for the senior tax break. I guess the other 10 percent stays in the general fund. Again, Im against the earmarking which deprives the legislature of its responsibility to allocate resources according to the particular needs of the particular year. But more than that, in an age of intense fire seasons, this is manipulation.

This proposition should have been disallowed in its form as it seems to violate the single-issue rule. On top of it, the measure would amount to a very convoluted Constitutional amendment and the California Constitution is already a mess because it is too easy to pass amendments.

Just, no.

Proposition 20 Very Convoluted and Complicated and One-sided Crime Bill Reform No

Over the past decade California voters have passed reforms intended to lower the prison population by reducing the number and length of prison sentences for other-than-violent crimes. In 2011 The US Supreme Court ordered California to release some of its prisoners who were suffering severe overcrowded conditions. The legislature responded by forcing counties to hold some of the state prisoners, which added strain to local systems and taxed their resources. In 2014 we passed Proposition 47 which reduced some low-level thefts and drug crimes from felonies to misdemeanors. Then we passed Proposition 57 which created sentencing and early release incentives to participate in rehabilitation programs for nonviolent crimes. Police unions were kicking and screaming the whole time arguing that it was going to result in massive chaotic dystopia across the state, during a several decades long phase in history in which crime rates have actually been declining. However, it appears that for certain types of theft in particular, such as car theft, there have actually been increases in some years, although the impact of Proposition 47 on that is a matter of strong dispute. UC Irvine conducted a study which suggests that there is no connection while the Public Policy Institute conducted a study which suggests that there is although again, the overall crime rate in California has been on a steady decline since 1990. The drafters disagree and have cited studies which suggest increased violent crime rates in some cities. And even the Public Policy Institute has concluded that there is no relationship between Proposition 47 and the spurts of violent crimes which seem to have gone up and down over the past decade mostly down.

Proposition 20 is heavily backed by police and prison guard unions.

The proposal is extremely convoluted and actually has some good ideas mixed with the bad. The weakness of Proposition 57 is that it really failed to define violent crime and the Courts have pretty much run with the statutory divisions which do not include domestic violence and sex crimes which dont involve physical force. Proposition 20 adds to the list of violent crimes over 50 crimes which ought to be on it to disqualify those convicted of the parole provisions made available by the ballot reforms. If this was all the measure did, I would have no objection. Im not against making serial theft a wobbler (can be charged as a misdemeanor or felony) in some cases, but I really do not think its necessary to make a felony out of theft of something at $250.00 in value, at least not for the first offence. The measure would make such a theft a wobbler if more than one person committed an organized retail crime.

And then the measure gets into a very detailed and extensive set of standards and practices for parole consideration, which may not be bad in and of themselves, but come strictly from a law enforcement perspective. It is the type of law which should be vetted in a legislative process, with experts and stakeholders from numerous facets of society to have input in the appropriate committees which would generate a legislative history which can provide guidance on the interpretation of the finalized law. This is not something which belongs on a ballot measure. I could list the provisions but your eyes would glaze over them. Few voters will read the proposal in its entirety, nor understand why some of the provisions are even in there.

The measure also seeks to expand DNA collection for database anyone convicted of everyone convicted of even minor theft and drug convictions on the theory that those convicted are going to move on to more serious crimes and so we should have their DNA in our system catch them. There is no accounting in the proposal for the civil libertarian notion that it is creepy for the government to be maintaining your DNA over a stupid mistake you might make in your youth. Yes, obviously you have nothing to worry about if you dont break the law again, but thats just not the point, nor is it the case

Basically, the measure would reduce the opportunities for parole and probation thats the whole point. It would result in an increase in incarceration and potentially jeopardize the states compliance with the Supreme Court order (although who knows if the order will survive the new SCOTUS makeup?). There is an extensive prison industry in California and it needs feeding, and that is whats fueling this measure. Wrong direction.

Proposition 21 Local Say in Rent Control Redux Yes

This is a watered-down version of 2018s Proposition 10 which I think lost because many people thought it was imposing a statewide rent control. It wasnt. But let me just repeat what I said two years ago.

Ive just about had it with biased documents/wording coming out of government, but the official Election Guide describes the proposition as expands local governments enact rent control Technically speaking this is true, but anyone who doesnt know the history or read the analysis carefully will fail to understand that was this does is to dial back overreach from Sacramento in the horrific Costa-Hawkins law passed by developer and Realtor lobby-pressured pols to impose statewide restrictions on rent control. Costa-Hawkins prohibits rent control for single-family homes. It prohibits vacancy rent control. And most egregiously it prohibits rent control of anything built from 1995 on which was purely a gift to developers.

This is exactly the kind of legislation conservatives claim to hate that which saps local control. It puts a premium on tearing down older homes. For the lack of vacancy rent control it assures gentrification and the destruction of working-class communities.

So, it went down in flames. Basically, the Costa-Hawkins act prohibits rent control on single-family housing, condos, townhouses and anything first occupied after 1995 (so basically nothing built within the past quarter-century and growing. Proposition 21 would basically allow property to be occupied for 15 years before it could be rent-controlled. And it would allow local governments to impose vacancy rent control. Allows rent increases on rent-controlled properties of up to 15 percent over three years from previous tenants rent above any increase allowed by local ordinance. It exempts rent control for anyone who owns no more than two home rentals.

I supported Proposition 10. Obviously, I support the more limited version as better than nothing.

Proposition 22 Exempts Uber from Labor Regulations No

The rise of the gig economy has accompanied the decline of union jobs in which a workers hours are regulated, unemployment and workers compensation insurance must be provided, and benefits pretty much non-existent as collective bargaining is not only impossible but completely contrary to the model.

Earlier in the year a California court ruled that gig workers must be treated as employees rather than independent contractors. The court granted a stay in the ruling pending appeal. Gig economy businesses have threatened to shut down their businesses saying that they cant afford to pay their contractors as employees. That threat just reveals the math.

Proposition 22 would exempt ride sharing and food delivery services from employment laws. Uber and Lyft have built their business models around the independent contractor status, reserving full-time employee status for corporate roles to keep costs low. Uber, Lyft, Doordash, Postmates, and Instacart have poured six figures of millions of dollars into the measure (some of that money no doubt the product of savings from exemption from having to pay a decent wage).

Im not a fan of the Uber model anyway. The data is in and they tend to focus their activity in public transit friendly areas which means lots more driving and traffic.

The business model is favored by many young drivers who like the flexibility, and there is mixed evidence as to whether Uber drivers make more money than taxi drivers due to optimized location and timing made inevitable by the app system. But if youre raising a family and you need to bring home a certain amount of money the flexibility is largely an illusion and your flexibility is limited by family and other needs. Sure, you can do something else, but the more the business model is allowed to flourish the bigger the negative impact on the non-hip portions of the working class who really do have to earn a living and bring home some healthcare and benefits. So, Uber closes up in California. Then maybe taxi companies who are subject to unions and overtime regulations will make comeback, perhaps even reproducing some of the app approaches which have made Uber the consumer choice. Of course, those rides arent as inexpensive, so maybe we will have to renew our quest for affordable and effective public transportation. Im sorry if the hipsters will be inconvenienced and have to go back to using public transit.

And by the way, there is nothing in the labor laws which deprives the companies of giving their workers time flexibility.

No, for a more worker-friendly economy.

Proposition 23 Dialysis Clinic Regulations Yes

Two years ago, Proposition 8 was introduced to place some regulations and profit caps on dialysis clinics of which private for-profit companies have a death grip and are being accused of having different tiers of levels of care depending on the source of your coverage specifically suggesting that Medi-Cal and Medicaid patients dont get the same quality of treatment.

Proposition 23 would require that a physician be present for all treatment except in circumstances of shortage of availability. It would require reporting to the state of all infections resulting from treatment with strong fines for non-compliance. It would require state approval before closing clinics or reducing services. And it would prohibit discrimination in treatment based upon your coverage; maintaining the same standards no matter what neighborhood youre in.

The clinic private industry spent over 100 million dollars to defeat Proposition 8 and it looks to be spending a similar amount against Proposition 23. Proposition went down in flames, partly because the American Nurses Association opposed it, though the more progressive California Nurses Association was curiously silent in 2018 and is not taking a position this time.

I do have some reservations about a ballot measure like this one. The initiative process is probably not the best vehicle to set medical treatment policy. I mean, do dialysis patients really need a medical doctor present, or are skilled nurses more than adequate? I dont know the answer to that question, and maybe thats the reason the CNA is staying out of this fight. This is the type of question which should be addressed by taking input in legislative committee with experts making their pitches one way and the other. But I have absolutely no doubt that in the affluent area clinics there is at least one physician present always, if only to give the affluent peace of mind.

And what I do know is that a for-profit model of health care is problematic when it is allowed to close clinics in poor areas and cut corners in treatment for patients whose coverage pays less after having displaced public and/or non-profit clinics. We hear the private insurers and health industry touting the benefits of free enterprise in generating the best care for everyone, but when expected to make good on those promises they say, Hey, were trying to run a business here! And in fact, they are cynically arguing that the SEIU wants to drive costs of operation up so that private businesses will close because unionization of dialysis workers has been difficult, which is patently ridiculous on several different levels.

And if having to report infections is really a cost-prohibitive burden, then maybe youre infecting too many people!

Note to the industry show us that your vaunted for-profit business model works and support these very basic regulations. That you are spending tens of millions to oppose this is really telling.

Proposition 24 Convoluted Consumer Privacy Protection Measure No

In 2018 the Legislature passed the California Consumer Protection Act, which is said to provide the strongest protection of digital consumer privacy of any state in the country, requiring permission from consumers before certain private information could be shared. Almost immediately tech companies and other businesses pushed to weaken it. And in fact, several bills to overhaul the law were stopped by State Senator Hannah-Beth Jackson who used her power as chair of the Judicial Committee to block them. She will be termed out next year, and the feeling of consumer privacy activists is that if the protections are not locked in by a ballot proposition which can only be amended by a subsequent ballot proposition the reforms will be lost or significantly watered down. The man who is spending a great deal of money to pass the measure is Alistair McCallister who says, There is basically unlimited resources on one side of the fight. If you dont do anything, they will win eventually.

Andrew Yang is also supporting it.

Im not even going to try to list the provisions of the 2018 law. Its huge. Here is the text if you want to read or skim it: https://theccpa.org/

What Proposition 24 adds is the creation of an enforcement agency; the removal of the opportunity to correct a violation to avoid penalty; to honor all consumer requests against the sharing of the designated information; allowing consumers an opt out for use of their sensitive personal information for advertising or marketing purposes; requiring affirmative permission for the use of information for anyone younger than 16; requiring parental permission for anyone under 13; and requiring that a business correct false consumer information upon request.

The measure attempts to eliminate some loopholes which have undermined the CCPA. For one thing, as noted earlier, it requires permission for a consumers information to be sold. But most of the data isnt sold at all. Websites willingly give their data to platforms like Facebook or Google in order to make it easier for them to sell their own subscriptions and advertising. The law also exempted companies designated service providers using the data for microtargeting advertising. Well, thats pretty much most of what Facebook and Google does for its advertising clients. Apparently Proposition 24 attempts to shut that down.

It all sounds good. So why are the ACLU, Dolores Huerta, the California Nurses Association, the Council on Islamic American Relations, the Media Alliance, and half a dozen consumer organizations opposed to it? The Devil is in the 52 pages of details. From the San Francisco Chronicle: Overall, its a step backward, said Jake Snow, an attorney for the American Civil Liberties Union of Northern California. It doesnt take into the account the burdens on poor communities and communities of color to pay for their privacy and to do the work to protect themselves.

Opponents say that the law would create a loophole which would allow the sale of small businesses many of whom do not have the time and money to go to the intricate lengths needed to attain the privacy and would aggravate what is being referred to as digital redlining or the digital divide in which poor people, disproportionately of color, are left behind. Proposition 24 allows companies to institute pay for privacy by charging more to those who opt out of sharing their information. CCPA already allows it to some degree, but this measure would entrench it, again, requiring a further ballot measure to change. If you are lower income you are going to opt for the lower rate and therefor it only benefits those for whom the difference in rates is no serious concern.

But the biggest issue is that the 52 pages of legalese is so dense that legal experts are disagreeing on the impact. I cant make sense out of much of it and Im an attorney. One example is over whether companies can by-pass the CCPA requirement of an opt-out app which basically notifies any business of the opt-out choice rather than having to manually opt out of each site, one by one. And were talking about 300 data brokers based in California. Proposition 24 seems to provide an out for the requirement to honor your app-conveyed wishes by offering an opt-out button somewhere on the website. But legal advocates for the measure argue that a few paragraphs later it says that businesses must honor global opt-outs and that the choice the businesses have are an opt-out button and forgoing the ability to charge more to opt-out customers. I cant be certain. It would have to be fought out in court, and unfortunately, a ballot proposition does not have any legislative history to guide interpretation.

Meanwhile, the California Democratic Party is neutral on the measure as is the Electronic Frontier Foundation which described the measure as a mixed bag of partial steps backwards and forwards.

And there are advocates who acknowledge the measures shortcomings, but fear that the gains of 2018 could be lost before a better measure is submitted and passed. Apparently, the pressure on the legislators is intense.

Another example the whole point is that Proposition 24 is supposed to prevent future legislation from weakening CCPA while allowing legislation to strengthen it. The measure specifies that any legislative amendments must be consistent with and further the purpose and intent of this Act, in order to further protect consumers rights, including the constitutional right of privacy. But then the measure lists 23 specific principles to be considered in the implementation of the policy as well as subsequent legislation including, for example avoiding anything which will stifle the development of new technology or place the consumer in a position to knowingly and freely negotiate with a business over the business use of the consumers personal information. This raises the fear that the initiative could, perversely, block the legislature from expanding privacy protections. What if there is legislation which places additional restrictions which will allow a company argue in court that this deprives users of the right to negotiate?

I could list further objections and ambiguities, but the problem is that for all its good intentions this is too complicated a measure to be decided by ballot. I sure hope we dont lose existing privacy protections, but if we do then maybe we can revisit them in a future ballot proposition. Democracy often does give the economically powerful an advantage in the process, but that is not an excuse to bypass democracy. And if lawyers cant even agree on the actual effect of the law, what chance does everyone else have to sort it out?

Sorry, no. I hate to vote against something like this because the media and political consensus might conclude that people really dont care about consumer privacy rights. But there is simply no way I can vote for a measure which gives me, an attorney, a splitting headache.

Proposition 25 Confirms Electorate Support of Bail Ban Yes

Careful with this measure. It was placed onto the ballot by people who oppose the legislatures 2018 ban of the bail system under a specific provision of the law which requires voter confirmation of certain types of laws passed before such law takes effect. Therefor a yes vote is to uphold the bail ban law and a no vote essentially repeals it.

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How to Vote This November: A Progressive's Opinion Redheaded Blackbelt - Redheaded Blackbelt

Cell Harvesting Market to Witness Steady Expansion During 2018-2023 – The Market Records

The global market for cell harvesting should grow from $885 million in 2018 to reach $1.5 billion by 2023 at a compound annual growth rate (CAGR) of 11.3% for the period of 2018-2023.

Report Scope:

The scope of the report encompasses the major types of cell harvesting that have been used and the cell harvesting technologies that are being developed by industry, government agencies and nonprofits. It analyzes current market status, examines drivers on future markets and presents forecasts of growth over the next five years.

The report provides a summary of the market, including a market snapshot and profiles of key players in the cell harvesting market. It provides an exhaustive segmentation analysis of the market with in-depth information about each segment. The overview section of the report provides a description of market trends and market dynamics, including drivers, restraints and opportunities. it provides information about market developments and future trends that can be useful for organizations, including wholesalers and exporters. It provides market positionings of key players using yardsticks of revenue, product portfolio, and recent activities. It further includes strategies adopted by emerging market players with strategic recommendations for new market entrants. Readers will also find historical and current market sizes and a discussion of the markets future potential. The report will help market players and new entrants make informed decisions about the production and exports of goods and services.

Get Access to sample pages @ https://www.trendsmarketresearch.com/report/sample/11685

Report Includes:

41 data tables and 22 additional tables Description of segments and dynamics of the cell harvesting market Analyses of global market trends with data from 2017, 2018, and projections of compound annual growth rates (CAGRs) through 2023 Characterization and quantification of market potential for cell harvesting by type of harvesting, procedure, end user, component/equipment and region A brief study and intact information about the market development, and future trends that can be useful for the organizations involved in Elaboration on the influence of government regulations, current technology, and the economic factors that will shape the future marketplace Key patents analysis and new product developments in cell harvesting market Detailed profiles of major companies of the industry, including Becton, Dickinson and Co., Corning, Inc., Fluidigm Corp., General Electric Co., Perkinelmer, Inc., and Thermo Fisher Scientific, Inc.

Summary

Stem cells are unspecialized cells that have the ability to divide indefinitely and produce specialized cells. The appropriate physiological and experimental conditions provided to the unspecialized cells give rise to certain specialized cells, including nerve cells, heart muscle cells and blood cells. Stem cells can divide and renew themselves over long periods of time. These cells are extensively found in multicellular organisms, wherein mammals, there are two types of stem cells embryonic stem cells and adult stemcells. Embryonic stem cells are derived from a human embryo four or five days old that is in the blastocyst phase of development. Adult stem cells grow after the development of the embryo and are found in tissues such as bone marrow, brain, blood vessels, blood, skin, skeletal muscles and liver. Stemcell culture is the process of harvesting the exosomes and molecules released by the stem cells for the development of therapeutics for chronic diseases such as cancer and diabetes. The process is widely used in biomedical applications such as therapy, diagnosis and biological drug production. The global cell harvesting market is likely to witness a growth rate of REDACTED during the forecast period of 2018-2023.The value of global cell harvesting market was REDACTED in 2017 and is projected to reach REDACTED by 2023. Market growth is attributed to factors such as increasing R&D spending in cell-based research,the introduction of 3D cell culture technology, increasing government funding, and the growing prevalence of chronic diseases such as cancer and diabetes.

The growing incidence and prevalence of cancer is seen as one of the major factors contributing to the growth of the global cell harvesting market. According to the World Health Organization (WHO), cancer is the second-leading cause of mortality globally and was responsible for an estimated 9.6 million deaths in 2018. Therefore, there is an increasing need for effective cancer treatment solutions globally. Cell harvesting is the preferred method used in cancer cell-related studies including cancer cell databases (cancer cell lines), and other analyses and drug discovery in a microenvironment. The rising prevalence of such chronic diseases has led governments to provide R&D funding to research institutes and biotechnology companies to develop advanced therapeutics. Various 3D cell culture technologies have been developed by researchers and biotechnology companies such as Lonza Group and Thermo Fischer Scientific for research applications such as cancer drug discovery. The application of cell culture in cancer research is leading to more predictive models for research, drug discovery and regenerative medicine applications.

Platelet-rich plasma (PRP) therapy, a new biotechnology solution that has a heightened interest among researchers in tissue engineering and cell-based therapies, has various applications in the treatment of tissue healing in tendinopathy, osteoarthritis and muscle injury. It has been conventionally employed in orthopedics, maxillofacial surgery, periodontal therapy and sports medicines. PRP therapy can be used in the treatment of fat grafting, acne scars, and hair regrowth.

Major factors driving market growth include increasing healthcare costs and the high rate of adoption for modern medicines in emerging economies such as China and India. It has been estimated that India will witness a CAGR of REDACTED in the cell harvesting market during the forecast period. The active participation of foreign pharmaceutical companies has tapped the Indian healthcare sector with a series of partnerships and mergers and acquisitions, which in turn is positively impacting the growth of the market in this region. Consistent development and clinical trials for stem cell therapies, plus contribution from the government and private sectors through investments and cohesive reimbursement policies in the development of cancer biomarkers, is further fueling market growth. InSweden, a research team at Lund University has developed a device to collect fluid and harvest stem mesenchymal stem cells (MSCs). The device is developed with 3D-printed bio-inert plastics which, when used by doctors, can result in the safe extraction of fluids (medical waste) from the patients body. The liquid is then passed through a gauze filter for purifying thoroughly and MSCs are separated from the fluid by centrifugation and are grown in culture.

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Cell Harvesting Market to Witness Steady Expansion During 2018-2023 - The Market Records