Autologous Stem Cell Based Therapies Market 2025 Dynamics, Segmentation, Size and Analysis by Latest Trends, Development and Growth by Regions and…

Umbilical Cord Blood Stem Cells

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Autologous Stem Cell Based Therapies Market TOC Covers the Following Points: 1 Study Coverage 1.1 Autologous Stem Cell Based Therapies Product 1.2 Market Segments 1.3 Key Manufacturers Covered 1.4 Market by Type 1.4.1 Global Market Size Growth Rate by Product 1.5 Market by End User 1.5.1 Global Market Size Growth Rate by End User 1.6 Study Objectives 1.7 Years Considered

2 Executive Summary 2.1 Global Market Size 2.1.1 Global Market Revenue 2014-2025 2.1.2 Global Market Sales 2014-2025 2.2 Growth Rate by Regions 2.2.1 Sales by Regions 2.2.2 Revenue by Regions

3 Breakdown Data by Manufacturers 3.1 Sales by Manufacturers 3.1.1 Sales by Manufacturers 3.1.2 Sales Market Share by Manufacturers 3.1.3 Global Market Concentration Ratio (CR5 and HHI) 3.2 Revenue by Manufacturers 3.2.1 Revenue by Manufacturers (2014-2019) 3.2.2 Revenue Share by Manufacturers (2014-2019) 3.3 Price by Manufacturers 3.4 Manufacturing Base Distribution, Product Types 3.4.1 Manufacturers Manufacturing Base Distribution, Headquarters 3.4.2 Manufacturers Product Type 3.4.3 Date of International Manufacturers Enter into Market 3.5 Manufacturers Mergers & Acquisitions, Expansion Plans

4 Breakdown Data by Product 4.1 Sales by Product 4.2 Revenue by Product 4.3 Price by Product

5 Breakdown Data by End User 5.1 Overview 5.2 Breakdown Data by End User

6 North America 6.1 North America Market by Countries 6.1.1 North America Market Sales by Countries 6.1.2 North America Market Revenue by Countries 6.1.3 United States 6.1.4 Canada 6.1.5 Mexico 6.2 North America Market by Product 6.3 North America Market by End User

7 Europe 7.1 Europe Market by Countries 7.1.1 Europe Market Sales by Countries 7.1.2 Europe Market Revenue by Countries 7.1.3 Germany 7.1.4 France 7.1.5 UK 7.1.6 Italy 7.1.7 Russia 7.2 Europe Market by Product 7.3 Europe Autologous Stem Cell Based Therapies by End User

8 Asia Pacific 8.1 Asia Pacific Market by Countries 8.1.1 Asia Pacific Autologous Stem Cell Based Therapies Sales by Countries 8.1.2 Asia Pacific Market Revenue by Countries 8.1.3 China 8.1.4 Japan 8.1.5 Korea 8.1.6 India 8.1.7 Australia 8.1.8 Indonesia 8.1.9 Malaysia 8.1.10 Philippines 8.1.11 Thailand 8.1.12 Vietnam 8.1.13 Singapore 8.2 Asia Pacific Market by Product 8.3 Asia Pacific Market by End User

9 Central & South America 9.1 Central & South America Autologous Stem Cell Based Therapies by Countries 9.1.1 Central & South America Market Sales by Countries 9.1.2 Central & South America Market Revenue by Countries 9.1.3 Brazil 9.2 Central & South America Market by Product 9.3 Central & South America Market by End User

10 Middle East and Africa 10.1 Middle East and Africa Market by Countries 10.1.1 Middle East and Africa Market Sales by Countries 10.1.2 Middle East and Africa Market Revenue by Countries 10.1.3 GCC Countries 10.1.4 Turkey 10.1.5 Egypt 10.1.6 South Africa 10.2 Middle East and Africa Market by Product 10.3 Middle East and Africa Market by End User

11 Company Profiles

12 Future Forecast 12.1 Market Forecast by Regions 12.1.1 Global Market Sales Forecast by Regions 2019-2025 12.1.2 Global Market Revenue Forecast by Regions 2019-2025 12.2 Market Forecast by Product 12.2.1 Global Sales Forecast by Product 2019-2025 12.2.2 Global Market Revenue Forecast by Product 2019-2025 12.3 Market Forecast by End User 12.4 North America Market Forecast 12.5 Europe Market Forecast 12.6 Asia Pacific Market Forecast 12.7 Central & South America Market Forecast 12.8 Middle East and Africa Market Forecast

13 Market Opportunities, Challenges, Risks and Influences Factors Analysis 13.1 Market Opportunities and Drivers 13.2 Market Challenges 13.3 Market Risks/Restraints 13.4 Macroscopic Indicators

14 Value Chain and Sales Channels Analysis 14.1 Value Chain Analysis 14.2 Autologous Stem Cell Based Therapies Customers 14.3 Sales Channels Analysis 14.3.1 Sales Channels 14.3.2 Distributors

15 Research Findings and Conclusion 16 Appendix 16.1 Research Methodology 16.1.1 Methodology/Research Approach 16.1.2 Data Source 16.2 Author Details 16.3 Disclaimer

Continued

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Autologous Stem Cell Based Therapies Market 2025 Dynamics, Segmentation, Size and Analysis by Latest Trends, Development and Growth by Regions and...

Global Stem Cell Therapies Market on a Steady Growth Trail; Future Market Insights Provides Projections in Light of COVID-19 Pandemic in its New…

With 1000+ market research reports and 1 billion+ data points, Future Market Insights (FMI) serves each and every requirement of the clients operating in the global healthcare, pharmaceuticals, and medical device industries. FMI deploys digital intelligence solutions to offer compelling insights to report buyers that help them in overcoming market challenges, especially at the time of a crisis. Our dedicated team of professionals performs an extensive survey for gathering accurate information associated with the market.

FMI, in its upcoming business report, elaborates the historical and current scenario of the global Stem Cell Therapies market in terms of production, consumption, volume, and value. The report scrutinizes the market into various segments, regions and players on the basis of demand pattern and growth prospects.

Crucial information and forecast statistics covered in the Stem Cell Therapies market report will arm both existing and emerging market players with necessary insights to craft long-term strategies as well as maintain business continuity during a crisis such as the ongoing COVID-19 pandemic.

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COVID-19 Impact Analysis on Stem Cell Therapies Market

The recent outbreak of the COVID-19 has turned the spotlight on the healthcare industry, and subsequently impacted the Stem Cell Therapies market. Severe shortages of critical medical supplies and a rapid rise in number of COVID-19 cases have resulted into a revolution rather than evolution in the healthcare ecosystems. Consequently, the impact is noticeable in the Stem Cell Therapies market.

Following governments measures, particularly social distancing norms and stay-at-home orders, doctors are delaying or postponing elective surgeries unless critical to prevent the spread of the virus to individuals with comorbidities or chronic conditions. Additionally, movement restrictions and supply chain disruptions have created a logistical nightmare for market players, leading to severe product shortages in the global marketplace.

The FMIs report includes an interesting chapter on preliminary impact of the COVID-19 on the Stem Cell Therapies market. This allows both leading and emerging market players to understand the market scenario during a crisis and aids them in making sound decisions to gain a distinct competitive edge.

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Stem Cell Therapies Market: Segmentation

Valuable information covered in the FMIs Stem Cell Therapies market report has been segregated into key segments and sub-segments.

By Treatment

By Application

Stem Cell Therapies Market: Competition Analysis

The FMIs study presents a comprehensive analysis of global, regional, and country-level players active in the Stem Cell Therapies market. Competitive information detailed in the Stem Cell Therapies market report has been based on innovative product launches, distribution channels, local networks, industrial penetration, production methods, and revenue generation of each market player. Furthermore, growth strategies and mergers & acquisitions (M&A) activities associated with the players are enclosed in the Stem Cell Therapies market report.

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Key players covered in the report include:

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Global Stem Cell Therapies Market on a Steady Growth Trail; Future Market Insights Provides Projections in Light of COVID-19 Pandemic in its New...

Stem Cell Banking Market is Booming Worldwide 2020-2027 By Product Analysis, By Application, By End-Users, By Regional Outlook, By Top Companies and…

China Cord Blood Corporation

Stem Cell Banking Market Segmentation:

Global Stem Cell Banking Market, by Service:

Analysis Storage Collection & Transportation Processing

Global Stem Cell Banking Market, by Application:

Leukemia Diabetes Autism Cerebral Palsy Thalassemia Others

Geographically, the Stem Cell Banking market report is segmented as North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. This analysis report similarly reduces the present, past, and future market business strategies, company extent, development, share, and estimate analysis having a place with the predicted circumstances. Moreover, the possible results and the exposure to the enhancement of the Stem Cell Banking market widely covered in this report.

Stem Cell Banking Market: Regional Analysis Includes:

Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

Europe(Turkey, Germany, Russia UK, Italy, France)

North America (The United States, Mexico, and Canada)

South America(Brazil etc)

The Middle East and Africa(GCC Countries and Egypt)

This report also describes the key challenges and threats possible. The report presents a full description of the strengths, weaknesses, opportunities, and threats to the Stem Cell Banking market. The market report provides the analytical tools that help identify the key external and internal factors that should be considered for the growth of the market. The report also helps companies in marketing for tasks like identifying their prospective customers, building relationships with them, and retention.

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Our 250 Analysts and SMEs offer a high level of expertise in data collection and governance use industrial techniques to collect and analyze data on more than 15,000 high impact and niche markets. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise, and years of collective experience to produce informative and accurate research.

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Stem Cell Banking Market is Booming Worldwide 2020-2027 By Product Analysis, By Application, By End-Users, By Regional Outlook, By Top Companies and...

Potential Impact of COVID-19 on Cancer Stem Cells Market: What to Expect from Industry in 2020? – Scientect

The COVID-19 pandemic is expected to impact the global cancer stem cells market in a positive way. Bladder cancer segment will flourish with healthier rate of revenue in the global market. Targeted cancer stem cells application segment is foreseen to gather a considerable amount of the global market share. Considering regions, Asia-Pacific region has dominated the global market share in the forecast period.

The world is facing an unexpected change and many of the industries are experiencing thought provoking situation due to the COVID-19 pandemic. The COVID-19 outbreak has positively impacted the cancer stem cells market. Many government bodies are investing money for research & development activities to enhance the utilization of cancer stem cells for the treatment of cancer cells.In addition, development of stem cells for stem line banking and developing induced pluri-potent stem cell (PSC) lines can be done for treatment of broad range of diseases from diabetes to arthritis. During this coronavirus crisis situation, we are helping our clients in understanding the impact of COVID-19 on the cancer stem cells market.

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Our report includes: Technological Impact Social Impact Investment Opportunity Analysis Pre- & Post-COVID Market Scenario Infrastructure Analysis Supply Side & Demand Side Impact

According to a new report published by Research Dive, the global cancer stem cells market is projected to generate a revenue of $1,898.3 million by 2026, at a CAGR of 11.8% in the forecast time from 2019 to 2026.

The global market segmentation has been done on the basis of cancer forms, application, and region. The report provides detailed information about drivers, opportunities, restraints, segmental analysis and competitive players of the market. As per our analysts, increased risk of cancer around the world and increased trend among youth for smoking is increasing the risk of cancer, which is significantly driving the market growth.

Based on cancer forms, the overall market is segmented intobreast, blood, lung, brain, colorectal, pancreatic, bladder, liver, and other. Among these, bladder cancer segment dominated the market in the year 2018 and is expected to register for $303.9 million in 2026. Deaths around the world due to bladder cancer account for nearly 150,000 per year. Many other treatments such as systemic immunotherapy, radiotherapy, and chemotherapy are used to treat but treating bladder cancer by utilization of cancer stem calls has resulted in positive outcome. According to the U.S. government, bladder cancer is the fifth most occurring cancer amongall other cancer types and thus positive impact of CSCs in the treatment will accelerate the growth of the market in the projected time.

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On the basis ofapplication, the cancer stem cells market is classified into stem cells cancer therapy and targeted cancerous stem cells. The market for targeted cancerous stem cells application segment will witness to rise at a rate of 13.0% CAGR and is predicted to register for $910.0 million till the end of 2026. Targeted cancerous stem cells have the potential to attract normal cells and can be utilized positively to target cancer cells owing to the interaction between normal cells and CSCs, resulting in reduced inflammation, angiogenesis, and tumor proliferation. These factors will fuel the market size in the forecast time.

Asia-Pacific market has dominated the global market share, and is estimated to reach up to $405.1 million till 2026. This dominance is attributed due to thepresence of significant number of associations actively engaged in the R&D of stem cell therapy. Asia-Pacific cancer stem cells market will experience a remarkable growth and projected to generate revenue of $405.17 million by the end of 2026, at a CAGR of 12.8%. This expected rise in the Asia-Pacific market is majorly due to funding agencies are providing permission to research associations to accelerate their R&D on cancer stem cells in other Asian countries and this aspect is predicted to boost the market growth in the projected time.

The most prominent players in the global cancer stem cells market include Thermo Fisher Scientific Inc., Merck KGaA, AbbVie Inc., Stem Cell Technologies Inc., Irvine Scientific, OncoMed Pharmaceuticals, Sino Biological Inc., BioTime Inc., MiltenyiBiotec and others.

Look for more statistical information at: https://www.prnewswire.com/news-releases/cancer-stem-cells-market-expected-to-generate-revenue-of1-722-7-million-growing-at-a-cagr-of-10-3-by-2026300996071.html

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Salk Institute: First immune-evading cells created to treat type 1 diabetes – Salk Institute scientists have made a major advance in the pursuit of a…

San Diego Community News Group

Salk Institute scientists have made a major advance in the pursuit of a safe and effective treatment for type 1 diabetes, an illness that impacts an estimated 1.6 million Americans with a cost of $14.4 billion annually.

Using stemcell technology, Salk researchers generated the first human insulin-producing pancreatic cell clusters able to evade the immune system, as detailed in the journalNatureonAugust 19, 2020. These immune shielded cell clusters controlled blood glucosewithout immunosuppressive drugsin mice,once transplanted in the body.

Most type 1 diabetics are children and teenagers, says Salk ProfessorRonald Evans, senior author and holder of the March of Dimes Chair in Molecular and Developmental Biology. This is a disease that is historically hard to manage with drugs. We hope that regenerative medicine in combination with immune shielding can make a real difference in the field by replacing damaged cells with lab-generated human islet-like cell clusters that produce normal amounts of insulin on demand.

Type 1 diabetes is a lifelong condition that is challenging to manage, even with automated devices that deliver insulin to regulate blood sugar. Transplants of pancreaticbetaisletsclusters of cells that make insulin and other hormonesfrom donor tissue can provide acure, butrequire patients to take life-long immunosuppressing drugs, which carry serious risks. For decades, researchers have sought a better way to replenish lost pancreatic cells. Now, device-free transplantation of insulin-producing cells like these bring us a step closer to curing the disease, according to the lab.

In aprevious study, the Evans lab overcame an impediment in the field,in which stem-cell-derived beta-like cells produced insulin, but were not functional. The cells did not release insulin in response to glucose,as they were simply under powered, according to Evans. His team discovered a genetic switch called ERR-gamma that when flipped, turbo-charges the cells.

When we add ERR-gamma, the cells have the energy they need to do their job, says Michael Downes, a Salk senior staff scientist and co-author of both studies. These cells are healthy and robust and can deliver insulin when they sense high glucose levels.

A critical part of the new study was to develop a way to grow beta-like cells in a three-dimensional environment that approximates the human pancreas. This gave the cells an islet-like property. Importantly, they discovered that a protein called WNT4 was able to turn on the ERR-gamma-driven maturation switch. This combination of steps generated functional cell clusters that mimic human islets: so-called human islet-like organoids (HILOs).

Next the team tackled the complex issue of immune rejection. Normal tissue transplants require lifelong immune suppressive therapies to protect the tissue from being attacked by the immune system;howeverthese therapies also increase the risk for infections. Inspired by the successes of immunotherapy drugs for cancer, the team initially showed that the checkpoint protein PD-L1 protected the transplanted cells. By expressing PD-L1, which acts as an immune blocker, the transplanted organoids are able to hide from the immune system, says first authorEijiYoshihara, a former staff scientist in the lab.

Yoshihara then developed a method to induce PD-L1 in HILOs with short pulses of the protein interferon gamma. When transplanted into diabetic mice, these immune-evasive HILOs provided sustained blood glucose control in diabetic mice with healthy immune systems.

This is the first study to show that you can protect HILOs from the immune system without genetic manipulation, Downes explains. If we are able to develop this as a therapy, patients will not need to take immune suppressing drugs.

More research needs to be done before this system can be advanced to clinical trials. The transplanted organoids need to be tested in mice for longer periods of time to confirm that their effects are long-lasting. More work needs to be done to ensuretheywould be safe to use in humans as well. We now have a product that could potentially be used in patients without requiring any kind of device,Evans concludes.

Other researchers on the paper wereCarolyn OConnor, Emanuel Gasser,ZongWei, TaeGyuOh, Tiffany W. Tseng, Dan Wang,Fritz Cayabyab,Yang Dai, Ruth T. Yu, and Annette R. Atkins of Salk and Christopher Liddle of theWestmeadInstitute for Medical Research and Sydney Medical School in Australia.

This work was supported by grants from California Institute of Regenerative Medicine grant DISC2-11175, National Institutes of Health grant 1RO1DK120480-01, the Leona M. and Harry B. Helmsley Charitable Trust,to Evans. Liddle and Downeswerefunded by grants from the National Health and Medical Research Council of Australia Project. Yoshiharawas supported by a DRC P&F grant.Thank you alsotoSteven and Lisa Altmanfor supporting the lab.

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Salk Institute: First immune-evading cells created to treat type 1 diabetes - Salk Institute scientists have made a major advance in the pursuit of a...

Survey: Impact Of Covid-19 On Land Mobile Radio System Market 2020 Industry Outlook, Opportunities in Market and Expansion By 2027 – Scientect

New research in theLand Mobile Radio System Market2020 with the real-time effects of COVID-19 on a global scale. The growth, analysis, opportunities, and CAGR of the Land Mobile Radio System market are been discussed thoroughly.

Immortalized Cell Line Market 2019-2027 global research report gives accurate information about market share, growth, trends, revenue, technology innovation, demand factors, regional scope as well as import-export statistics. Immortalized Cell Line Industry segmented view based on key players, regions, type and an application will help the Immortalized Cell Line market aspirants in planning their business.

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Introduction, Immortalized cell lines are either tumorous cells that do not stop dividing or cells that have been artificially manipulated to proliferate indefinitely and can, thus, be cultured over several generations. HepaRG and Hep G2 cell lines are most frequently used for toxicity studies among the currently available human hepatic cell lines., The immortalized cell line plays a vital role in cell biology while studying multicellular organisms and their biochemistry. The demand for immortalized cell lines is increasing and so as the applications. The increasing adoption of immortalized cell lines in stem cell therapy drives the growth of the market., Besides, the increasing awareness regarding the use of cell lines in healthcare, rising vaccines production, increasing application of cell lines in cancer therapy, and use of innovative technology for cell lines have fueled the growth of the market. On the other hand, the high cost of equipment and difficulties in developing a stable and authentic strain have restrained the growth of the immortalized cell line market. , Moreover, continuous cell lines are widely used by numerous pharmaceutical and biotech-based companies as a specimen for testing the drug efficacy. Due to this, there is a reduction in the use of gnotobiotic animals such as mice, rabbits, and monkeys, among others. Moreover, as these cell lines have a long shelf life and can be easily preserved via cryopreservation and lyophilization techniques, several biotech and pharmaceutical companies are preferring them over other media cultures for performing their R&D activities. For instance, as per a report published by the Department of Pharmaceutical Sciences and Bio Manufacturing Research Institute and Technology Enterprises (BRITE), in 2014, around 1.3 USD billion capital was invested in new pharmaceuticals for drug discovery through cell line culture., The global immortalized cell line market is segmented based on method, application, and end-user., Based on method, the market is further segmented into virus induction, HTERT expression, inactivation of tumor, suppression genes, and others. , Based on application, the market is segmented into diagnostics, drug discovery, vaccine production, tissue engineering and regenerative medicine, and others., Based on end-user, the market is segmented into pharmaceutical and biopharmaceutical companies, contract research organizations, and research laboratories., The global immortalized cell line market was valued at USD 2,421.34 million in 2017 and is expected to register a CAGR of 9.30% during the forecast period from 2018 to 2023

List ofTop Key Playersof Land Mobile Radio System Market:

Thermo Fisher Scientific, ATCC (American Type Culture Collection Inc.), Valneva, Sartorius AG, Lonza Group, AG, Merck KGaA, Selexis SA, Wuxi App Tec, European Collection of Authenticated Cell Cultures (ECACC), Corning Incorporated

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Land Mobile Radio System Market Table Of Content Covers the Following Points: 1 Report Overview

1.1 Study Scope

1.2 Key Market Segments

1.3 Regulatory Scenario by Region/Country

1.4 Market Investment Scenario Strategic

1.5 Market Analysis by Type

1.5.1 Global Land Mobile Radio System Market Share by Type (2020-2027)

1.6 Market by Application

1.6.1 Global Land Mobile Radio System Market Share by Application (2020-2027)

1.7 Land Mobile Radio System Industry Development Trends under COVID-19 Outbreak

1.7.1 Global COVID-19 Status Overview

1.7.2 Influence of COVID-19 Outbreak on Land Mobile Radio System Industry Development

2.1 Industry Trends

2.1.1 SWOT Analysis

2.1.2 Porters Five Forces Analysis

2.2 Potential Market and Growth Potential Analysis

2.3 Industry News and Policies by Regions

2.3.1 Industry News

2.3.2 Industry Policies

2.4 Industry Trends Under COVID-19

3 Value Chain of Land Mobile Radio System Market

3.1 Value Chain Status

3.2 Land Mobile Radio System Manufacturing Cost Structure Analysis

3.2.1 Production Process Analysis

3.2.2 Manufacturing Cost Structure of Land Mobile Radio System

3.2.3 Labor Cost of Land Mobile Radio System

3.2.3.1 Labor Cost of Land Mobile Radio System Under COVID-19

3.3 Sales and Marketing Model Analysis

3.4 Downstream Major Customer Analysis (by Region)

3.5 Value Chain Status Under COVID-19

4 Players Profiles

5 Global Land Mobile Radio System Market Analysis by Regions

5.1 Global Land Mobile Radio System Sales, Revenue and Market Share by Regions

5.1.1 Global Land Mobile Radio System Sales by Regions (2015-2020)

5.1.2 Global Land Mobile Radio System Revenue by Regions (2015-2020)

5.2 North America Land Mobile Radio System Sales and Growth Rate (2015-2020)

5.3 Europe Land Mobile Radio System Sales and Growth Rate (2015-2020)

5.4 Asia-Pacific Land Mobile Radio System Sales and Growth Rate (2015-2020)

5.5 Middle East and Africa Land Mobile Radio System Sales and Growth Rate (2015-2020)

5.6 South America Land Mobile Radio System Sales and Growth Rate (2015-2020)

6 North America Land Mobile Radio System Market Analysis by Countries

6.1 North America Land Mobile Radio System Sales, Revenue and Market Share by Countries

6.1.1 North America Land Mobile Radio System Sales by Countries (2015-2020)

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Survey: Impact Of Covid-19 On Land Mobile Radio System Market 2020 Industry Outlook, Opportunities in Market and Expansion By 2027 - Scientect

Expression Therapeutics Announces Success in Developing a Stem Cell Lentiviral Gene Therapy for Hemophagocytic Lymphohistiocytosis (HLH) – PRNewswire

ATLANTA, Aug. 24, 2020 /PRNewswire/ -- Primary HLH is a family of devastating primary immune deficiencies with limited treatment options and no gene therapies under clinical testing. Expression Therapeutics has developed a promising and potentially curative gene therapy candidate for familial hemophagocytic lymphohistiocytosis (HLH) type 3 (FHL3). Untreated, FHL3 presents as a hyper-inflammatory state with multi-organ damage leading to premature death. Expression Therapeutics expects to rapidly progress candidates for other common forms of primary HLH as well.

"We are excited to announce this expansion of our gene and cell therapy pipeline beyond our lead stem cell lentiviral gene therapy candidate for hemophilia A that is entering Phase 1 clinical testing. Through ongoing research and development incorporating our core technology platforms, Expression Therapeutics has been able to rapidly generate promising therapeutic candidates for our HLH portfolio and several other critical disease areas with significant unmet clinical need," said Christopher Doering, Ph.D., Chief Scientific Officer of Expression Therapeutics.

Proof of concept for stem cell lentiviral gene therapy of FHL3 was demonstrated using primary patient cells and a genetic mouse model of FHL3. A key component in this success was the integration of one of Expression Therapeutics' core technology platforms that facilitates the rapid generation of transgenes with superior potency. Our lead candidate successfully restored exocytosis and cytolytic function to primary patient cells as well as a murine disease model strongly supporting the advancement of this pipeline product candidate.

"We believe there are three key aspects to FHL3 that make it a strong candidate for hematopoietic stem and progenitor cell (HSPC) lentiviral vector (LV) gene therapy. First, preclinical and clinical studies suggest that less than 20% genetically corrected cells are required to reverse most FHL3 disease symptoms. Second, because of the autologous nature of stem cell-based lentiviral gene therapy, the grave risk of graft vs host disease is eliminated. Third, with stem cell-based lentiviral gene therapy there will be no wait time to find a sufficiently human leukocyte antigen-matched donor," said Trent Spencer, Ph.D., President of Expression Therapeutics.

According to Deanna Fournier, Executive Director of the Histiocytosis Association, "We are very excited about the possibilities this work offers. Our HLH community, and the entire histiocytosis community, is very hopeful and excited about the future!"

Expression Therapeutics is a biotechnology company based in Atlanta and Cincinnati. The current therapeutic pipeline includes advanced gene therapies for hemophilia, neuroblastoma, T-cell leukemia/lymphoma, acute myeloid leukemia (AML), and primary immunodeficiencies such as hemophagocytic lymphohistiocytosis (HLH).

For inquiries, please contact:

Ashley Walsh Director of Corporate Development Expression Therapeutics 1860 Montreal Road Tucker, Georgia 30084 [emailprotected] +1 312.637.2975 http://www.expressiontherapeutics.com

SOURCE Expression Therapeutics

http://www.expressiontherapeutics.com

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Expression Therapeutics Announces Success in Developing a Stem Cell Lentiviral Gene Therapy for Hemophagocytic Lymphohistiocytosis (HLH) - PRNewswire

Nearly 40 Maryland companies, universities working on vaccines, therapeutics, diagnostic tests and clinical research – WV News

ANNAPOLIS Governor Larry Hogan has commended the nearly 40 Maryland life sciences companies that are working on developing and manufacturing COVID-19 vaccines and therapeutics, improving diagnostic tests and providing clinical research and technological support to ensure safe and effective health care delivery.

The University System of Maryland and Johns Hopkins University have also dedicated millions of dollars toward research, testing and clinical trials.

The University of Maryland School of Medicine recently began phase 3 trials of a COVID-19 vaccine.

On the day of our first coronavirus cases, I said that Maryland was home to some of the top health research facilities in the world, and vowed that we would be a part of developing treatments and perhaps even a vaccine for this deadly virus, said Hogan. I want to commend our world-class life sciences community, our universities, and federal research labs for working together to fight this unprecedented global pandemic. Our state will continue to lead on the road to recovery.

To date, Marylands life sciences companies have secured more than $3 billion for the development of a vaccine for SARS-CoV-2, the virus that causes COVID-19.

Gaithersburg-based Novavax was awarded $1.6 billion through Operation Warp Speed to complete late-stage clinical development, establish large-scale manufacturing, and deliver 100 million vaccine doses as early as late 2020, as well as $388 million from the international Coalition for Epidemic Preparedness Innovations and $60 million through a U.S. Department of Defense contract to support vaccine production.

Emergent BioSolutions, with its headquarters and product development facility also based in Gaithersburg and three manufacturing facilities in Baltimore and Rockville, announced it signed contracts with AstraZeneca, Johnson & Johnson, Novavax, and Vaxart as well as with Operation Warp Speed for a total of $1.5 billion to support COVID-19 vaccine candidate development and manufacturing.

Bethesda-based Longhorn Vaccines and Diagnostics won a $225 million U.S. Department of Homeland Security contract to transport clinical samples to testing labs.

Altimmune, headquartered in Gaithersburg, was awarded a $4.7 million contract from the U.S. Army Medical Research and Development Command and is working with Rockville-based Vigene Biosciences on the development of a single-dose intranasal COVID-19 vaccine.

Emergent is proud to be a part of Marylands efforts to fight the COVID-19 pandemic, said Robert G. Kramer, president and CEO of Emergent BioSolutions. Marylands life sciences cluster enhances our ability to partner with pharmaceutical and biotechnology innovators. Along with our longstanding partnership with the federal government in support of its efforts to combat public health threats, we are uniquely positioned to work quickly to help advance vaccine and hyperimmune therapeutic candidates.

We are grateful to be part of Marylands collaborative life sciences cluster that, together with the states superb academic institutions, is making rapid progress in the fight against COVID-19, said Stanley C. Erck, president and chief executive officer of Novavax. Novavaxs swift response in developing one of the worlds most promising vaccines for this pandemic is a testament to the value of these close relationships, rich local resources, and government support in effectively addressing pressing public health needs.

The University System of Maryland and Johns Hopkins University both mobilized quickly to develop a comprehensive response to the pandemic. Johns Hopkins dedicated $6 million in funding to support about 260 scientists and researchers working on more than two dozen projects related to COVID-19.

In addition, Hopkins School of Medicine is conducting more than 100 clinical studies to develop COVID-19 diagnostics and, with $35 million from the U.S. Department of Defense, is working with the Bloomberg School of Public Health to test the efficacy of blood plasma from COVID-19 survivors as a treatment option.

The University System of Maryland faculty are working to develop a rapid COVID-19 test and are conducting a clinical trial of experimental stem cell therapy to reduce death in the sickest patients. The University of Maryland School of Medicine will receive up to $3.6 million over the next year from the Defense Advanced Research Projects Agency to rapidly test hundreds of drugs, approved and marketed for other conditions, to see if any can be repurposed to prevent and treat COVID-19.

Its in crises like these that you see why Maryland is one of the countrys top biosciences hubs, said University System of Maryland Chancellor Jay A. Perman. Our USM institutions are on the front lines developing COVID-19 diagnostics and therapeutics, testing multiple vaccines, leading dozens of other R&D projects. But theyre also reaching out to our close industry partners, joining our assets and expertise to theirs so we can quickly commercialize COVID-19 solutions. There are few states that have the breadth and depth of our life sciences talent, and fewer still that have an ecosystem like ours that thrives on collaboration.

As we confront a global pandemic on a scale not experienced since the 1918 flu, it is remarkable to see the extraordinary depth and breadth of expertise being galvanized against COVID from right here in Maryland, said Ron Daniels, president of Johns Hopkins University. Johns Hopkins researchers quickly mobilized to launch an emergency, cross-divisional COVID-19 research program to stem the tide of the virus and save lives. From investigating the underlying biology and developing treatments for the disease to addressing its devastating impact on our local communities, and reporting rigorous data about its spread, Hopkins researchers are at the forefront of the fight to stop COVID-19.

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Nearly 40 Maryland companies, universities working on vaccines, therapeutics, diagnostic tests and clinical research - WV News

Global Cancer Stem Cell Market 2020 Top Industry Players Thermo Fisher Scientific, Inc., AbbVie, Inc., Merck KGaA, Bionomics, Lonza, Stemline…

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Global Cancer Stem Cell Market 2020 Top Industry Players Thermo Fisher Scientific, Inc., AbbVie, Inc., Merck KGaA, Bionomics, Lonza, Stemline...

Researchers Find Method to Regrow Cartilage in the Joints, Proof of Principle Study Shows – Technology Networks

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Researchers at the Stanford University School of Medicine have discovered a way to regenerate, in mice and human tissue, the cushion of cartilage found in joints.

Loss of this slippery and shock-absorbing tissue layer, called articular cartilage, is responsible for many cases of joint pain and arthritis, which afflicts more than 55 million Americans. Nearly 1 in 4 adult Americans suffer from arthritis, and far more are burdened by joint pain and inflammation generally.

The Stanford researchers figured out how to regrow articular cartilage by first causing slight injury to the joint tissue, then using chemical signals to steer the growth of skeletal stem cells as the injuries heal. The work was published Aug. 17 in the journal Nature Medicine.

Cartilage has practically zero regenerative potential in adulthood, so once its injured or gone, what we can do for patients has been very limited, said assistant professor of surgery Charles K.F. Chan, PhD. Its extremely gratifying to find a way to help the body regrow this important tissue.

The work builds on previous research at Stanford that resulted in isolation of the skeletal stem cell, a self-renewing cell that is also responsible for the production of bone, cartilage and a special type of cell that helps blood cells develop in bone marrow. The new research, like previous discoveries of mouse and human skeletal stem cells, were mostly carried out in the laboratories of Chan and professor of surgery Michael Longaker, MD.

Articular cartilage is a complex and specialized tissue that provides a slick and bouncy cushion between bones at the joints. When this cartilage is damaged by trauma, disease or simply thins with age, bones can rub directly against each other, causing pain and inflammation, which can eventually result in arthritis.

Damaged cartilage can be treated through a technique called microfracture, in which tiny holes are drilled in the surface of a joint. The microfracture technique prompts the body to create new tissue in the joint, but the new tissue is not much like cartilage.

Microfracture results in what is called fibrocartilage, which is really more like scar tissue than natural cartilage, said Chan. It covers the bone and is better than nothing, but it doesnt have the bounce and elasticity of natural cartilage, and it tends to degrade relatively quickly.

The most recent research arose, in part, through the work of surgeon Matthew Murphy, PhD, a visiting researcher at Stanford who is now at the University of Manchester. I never felt anyone really understood how microfracture really worked, Murphy said. I realized the only way to understand the process was to look at what stem cells are doing after microfracture. Murphy is the lead author on the paper. Chan and Longaker are co-senior authors.

For a long time, Chan said, people assumed that adult cartilage did not regenerate after injury because the tissue did not have many skeletal stem cells that could be activated. Working in a mouse model, the team documented that microfracture did activate skeletal stem cells. Left to their own devices, however, those activated skeletal stem cells regenerated fibrocartilage in the joint.

But what if the healing process after microfracture could be steered toward development of cartilage and away from fibrocartilage? The researchers knew that as bone develops, cells must first go through a cartilage stage before turning into bone. They had the idea that they might encourage the skeletal stem cells in the joint to start along a path toward becoming bone, but stop the process at the cartilage stage.

The researchers used a powerful molecule called bone morphogenetic protein 2 (BMP2) to initiate bone formation after microfracture, but then stopped the process midway with a molecule that blocked another signaling molecule important in bone formation, called vascular endothelial growth factor (VEGF).

What we ended up with was cartilage that is made of the same sort of cells as natural cartilage with comparable mechanical properties, unlike the fibrocartilage that we usually get, Chan said. It also restored mobility to osteoarthritic mice and significantly reduced their pain.

As a proof of principle that this might also work in humans, the researchers transferred human tissue into mice that were bred to not reject the tissue, and were able to show that human skeletal stem cells could be steered toward bone development but stopped at the cartilage stage.

The next stage of research is to conduct similar experiments in larger animals before starting human clinical trials. Murphy points out that because of the difficulty in working with very small mouse joints, there might be some improvements to the system they could make as they move into relatively larger joints.

The first human clinical trials might be for people who have arthritis in their fingers and toes. We might start with small joints, and if that works we would move up to larger joints like knees, Murphy says. Right now, one of the most common surgeries for arthritis in the fingers is to have the bone at the base of the thumb taken out. In such cases we might try this to save the joint, and if it doesnt work we just take out the bone as we would have anyway. Theres a big potential for improvement, and the downside is that we would be back to where we were before.

Longaker points out that one advantage of their discovery is that the main components of a potential therapy are approved as safe and effective by the FDA. BMP2 has already been approved for helping bone heal, and VEGF inhibitors are already used as anti-cancer therapies, Longaker said. This would help speed the approval of any therapy we develop.

Joint replacement surgery has revolutionized how doctors treat arthritis and is very common: By age 80, 1 in 10 people will have a hip replacement and 1 in 20 will have a knee replaced. But such joint replacement is extremely invasive, has a limited lifespan and is performed only after arthritis hits and patients endure lasting pain. The researchers say they can envision a time when people are able to avoid getting arthritis in the first place by rejuvenating their cartilage in their joints before it is badly degraded.

One idea is to follow a Jiffy Lube model of cartilage replenishment, Longaker said. You dont wait for damage to accumulate you go in periodically and use this technique to boost your articular cartilage before you have a problem.

Reference:

Murphy et al. Articular cartilage regeneration by activated skeletal stem cells, Nature Medicine (2020). DOI: 10.1038/s41591-020-1013-2

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Researchers Find Method to Regrow Cartilage in the Joints, Proof of Principle Study Shows - Technology Networks