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Boy, 4, may look fighting fit but only has months to live – unless you can save him – Mirror Online

By Stem Cell Doctors

His name means brave in Hindi. And for four year-old Veer Gudhka that couldnt be more appropriate.

For while the bubbly little boy might look fighting fit, he actually has just months to live.

Veer suffers from a rare blood disorder called Fanconi anaemia, which results in a decreased production of all types of blood cells.

But a stem cell donor will save his life.

In a heartfelt video message, the plucky toddler asks Sunday Mirror readers: Please be my life-saver? Will you be my superhero?

And today his family are appealing to those from BAME communities to help by signing up to the Anthony Nolan stem cell register.

Mum Kirpa and dad Nirav know the odds are stacked against them getting that all-important call because they are of Indian descent.

While 69 per cent of Northern European patients find the best possible stem cell match from a stranger, this drops to just 20 per cent for those with black, Asian or ethnic minority backgrounds.

Survival

Currently only two per cent of the population is on the UK stem cell register. And with Asians making up just six per cent of the UK population, there is a smaller pool of potential donors.

Veer was diagnosed with the blood disorder last August, after he started suffering from extreme fatigue, and was referred for tests.

Doctors said he would need a stem cell transplant within three years for a chance of survival.

They hoped to buy Veer some time by putting him on steroids to boost his blood counts. But his condition has deteriorated fast.

Recent tests at Great Ormond Street Hospital in London show he now has just three to four months to find a donor.

Kirpa and Nirav were both tested, along with Veers six-year-old sister Suhani, but none of them were a match.

A search on the global stem cell register also drew a blank.

And his dad has been trying to encourage his fellow countrymen and women in India to join the register.

They have even signed up a female battalion of the Indian Army.

Kirpa, 37, from Harrow, London, said: We just feel so scared were going to lose our cheeky, amazing little boy. To look at Veer you wouldnt know hes critically ill.

Like his name, hes been brave from the start. Hes undergone countless tests and hospital visits but has had a constant smile on his face.

"He knows he needs a superhero to step forward, but his optimism and enthusiasm are infectious and keep us all going.

She added: Going on the register is incredibly quick and donating cells if you match someone in need is painless.

You can join the Anthony Nolan stem cell register today.

Nine out of 10 people donate their stem cells through the bloodstream in a simple IV process called peripheral blood stem cell collection.

One in 10 will have their stem cells collected via the bone marrow itself, while under general anaesthetic. Doctors transplant the new, healthy cells via the patients bloodstream, where they begin to grow and create healthy red blood cells, white blood cells and platelets.

A perfect match from a donor can mean a lifelong cure.

Veers dad Nirav, 40, said: I only learned about the Anthony Nolan stem cell register two years ago and even then I assumed it would involve long and painful procedures.

We need to raise awareness to save lives in every community.

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Boy, 4, may look fighting fit but only has months to live - unless you can save him - Mirror Online

Post chemotherapy may leave patients vulnerable to infections – APN News

By Stem Cell Doctors

Published on August 7, 2020

Mr. Raktim Chattopadhyay, Founder & CEO, Esperer Onco Nutrition (EON)

The link between the immune system and cancer has been widely appreciated for over a century and was first highlighted by Rudolph Virchow over 150 years ago . The underlying basis for this relationship between cancer and immunity involves three basic principles of how the immune system acts to defend and protect an individual: it detects nonself antigens from pathogens or infected/malignant cells; it encompasses effector functions to specifically target and destroy the pathogen or infected/malignant cells while protecting the host, and it develops immunological memory via the adaptive immune responses for subsequent defence mechanisms following an injury or an attack against the host . Through this process, the immune system has acquired characteristics that give rise to the paradigm known as immunoediting, which provides a balance between immune surveillance and cancer progression in the realm of oncology.In the rapidly evolving field of immune-oncology, understanding the tumor-specific immune response enhances understanding of cancer resistance.

Most cancer patients know that chemotherapy weakens their immune systems, putting them at risk for viral and bacterial infections. A month or two after chemo ends, most people think their immune system has returned to normal. Research suggests that the effects of chemotherapy can compromise part of the immune system for up to nine months after treatment, leaving patients vulnerable to infections especially with certain type of chemotherapy treatment regimen.

So, cancer and cancer treatments can affect the immune system and other body systems in different ways. People with cancer might be more likely to get infections because of:

Cancer treatments can interfere with the way the immune system works. The damage can be short- or long-term. For example, if a person with cancer has their spleen removed due to cancer, this causes long-term damage because the spleen is part of the immune system. On the other hand, radiation therapy, immunotherapy, and chemotherapy, either alone or in combination can lead to short-term (temporary) immune system damage because they affect immune system blood cells for a fairly short period of time. Abone marrow or stem cell transplant uses very high-dose treatments to kill cancer cells that also damageimmune system cells for weeks to months.

Keeping the above in mind cancer patients must consider the following as per international guidelines:

Dont ignore minor symptoms. If you are feeling unwell, get to your doctor and get it checked out right away. What may be a minor issue could turn into something bigger.

Talk to your health care provider to make sure youre up to date on all of your vaccines. Many cancer patients after treatment should be able to receive many vaccines, including flu and pneumonia vaccines.

Exercise and eat healthfully. Those things never hurt immune response or your recovery.

If you smoke, try to quit.

If someone in your family or in your care has cancer, make sure youre up to date on vaccines and preventive care. The last thing you want to do is develop an infection that doesnt allow you to care for them or puts them at risk.

Since patients are most at risk right after theyve received chemo. Its really important to protect your family members when theyre at the highest risk for major infectious complications.

Supporting the immune system while battling cancer is imperative and one of the factors that aid in the healing process from the aftermath of the treatment therapy. Protective effects can be observed while balancing dietary and lifestyle needs, however, these alone do not promise an immunity boost. The immune system works as powerful weapon against disease, but it is a known fact that with cancer, immunity is at high risk where healthy cells are attacked causing a variety of side effects.

Cancer patients are at a natural high risk of malnutrition as chemotherapies, radiations and surgeries can lead to loss of appetite, stress, fatigue, anxiety making it difficult to eat with a high appetite loss. This leads to a significant reduced response in cancer treatment, increases risk of survival. Cancer cells replicate by division to replace old cells and multiply thus some damaged cells might migrate to other tissues causing tumour growth. The longer, cancer continues to grow the lesser possibilities are available for the immune system to recognize damaged cells and destroy them.

Vitamins, foods, minerals are recommended by doctors but a key concern to examine is are these long term & sustainable to ensure quality life for patients?

A need for preparing the body for heavy dose of cancer treatment at the time of diagnosis, during treatment and post procedure is important for long term risk benefits. All 3 phases are different and require nutritional care basis the cell biology of the body. Health supplements of the correct formulation with technology backed research can be an optimum solution. The supplements can bring about efficacy in the main therapy of cancer disease management and improve overall quality of life.

Time has come to focus on optimal physical and psycho-social well-being of the patient in cancer therapy. The treatment of a lethal and supposedly incurable disease like cancer takes a toll on people emotionally, financially and physically. The right approach for organizations to help mitigate the risks of cancer though various methods would be to have an all-inclusive outlook catering to all of the above effects. The goal should be to help and support the end user with a view of futuristic need for living a fulfilling life even after being cured, while focusing on every aspect of oncology. A certain kind of after care is always mandatory during & post treatment which could be complex and costly. Anticancer products is the future, which will have to align parallel in such a way so the therapy protocol can be made affordable to the receivers.

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Post chemotherapy may leave patients vulnerable to infections - APN News

Immatics Extends Cell Therapy Manufacturing Collaboration with UTHealth | 2020-08-06 | Press Releases – Stockhouse

By Stem Cell Treatment

Houston, Texas, Aug. 06, 2020 (GLOBE NEWSWIRE) --

Houston, Texas, August 6, 2020 Immatics N.V. (NASDAQ: IMTX; Immatics”), a clinical-stage biopharmaceutical company active in the discovery and development of T cell redirecting cancer immunotherapies, today announced the extension of its cell therapy manufacturing collaboration with The University of Texas Health Science Center at Houston (UTHealth), in Houston, Texas. The continued collaboration grants Immatics access to UTHealth’s state-of-the-art cGMP manufacturing infrastructure at the Evelyn H. Griffin Stem Cell Therapeutics Research Laboratory, enabling continued production and supply of Immatics’ specialized, cell-based product candidates for testing in multiple clinical trials. Maximum capacity of the facility is anticipated at 48 ACTengine® T cell products per month. The new agreement will run until the end of 2024. Under the agreement, UTHealth will provide Immatics with exclusive access to three cGMP suites and support areas for the manufacturing of various Adoptive Cell Therapy (ACT) products. Therapeutic T cell production will be carried out by Immatics’ manufacturing personnel and will be supported by a UTHealth-Immatics joint quality team.

Steffen Walter, Ph.D., Chief Technology Officer at Immatics, commented: During the last five years, we have established a strong and productive partnership with UTHealth that has enabled the initiation of four ongoing clinical trials. As we remain focused on the development of our clinical pipeline, this extension of our collaboration with UTHealth will fulfill Immatics’ manufacturing needs for our early-stage ACT clinical programs for the next four years. Being able to rely on a partner with profound cell therapy expertise who is familiar with our technologies and can support cGMP cell therapy production is critical to ensuring the advancement of our clinical trials. We look forward to continuing this fruitful collaboration with the experts at UTHealth.”

Fabio Triolo, D.d.R., M.Phil., Ph.D., The Clare A. Glassell Distinguished Chair and Director of the Cellular Therapy Core at UTHealth, added: Signing the extended contract with Immatics fits into our strategy at UTHealth of supporting the development of new treatments for patients in need. We therefore look forward to continuing our collaboration and further leveraging the potential of our manufacturing capabilities.”

About Immatics’ ACT Programs ACTengine® is a personalized approach in which the patient’s own T cells are genetically modified to express a novel proprietary TCR cognate to one of Immatics’ proprietary cancer targets which are then reinfused back into the patient. Immatics’ latest proprietary ACTengine® manufacturing processes are designed to generate cell product candidates within a short six day manufacturing window and to deliver highly proliferative T cells, with the capability to infiltrate the patient’s tumor and function in a challenging solid tumor microenvironment. The process is designed to rapidly produce younger, better-persisting T cells capable of serial” killing tumor cells in vitro. Immatics’ is further advancing the ACT concept beyond individualized manufacturing with its product class ACTallo® which is being developed to generate off-the-shelf” cellular therapies.

More information on the clinical trials can be found at the following links: https://immatics.com/clinical-programs/ and https://clinicaltrials.gov/.

- ENDS - Notes to Editors

About Immatics Immatics combines the discovery of true targets for cancer immunotherapies with the development of the right T cell receptors with the goal of enabling a robust and specific T cell response against these targets. This deep know-how is the foundation for our pipeline of Adoptive Cell Therapies and TCR Bispecifics as well as our partnerships with global leaders in the pharmaceutical industry. We are committed to delivering the power of T cells and to unlocking new avenues for patients in their fight against cancer.

For regular updates about Immatics, visit http://www.immatics.com. You can also follow us on Twitter and LinkedIn.

About UTHealth Established in 1972 by The University of Texas System Board of Regents, The University of Texas Health Science Center at Houston (UTHealth) is Houston’s Health University and Texas’ resource for health care education, innovation, scientific discovery and excellence in patient care. The most comprehensive academic health center in the UT System and the U.S. Gulf Coast region, UTHealth is home to Jane and Robert Cizik School of Nursing, John P. and Kathrine G. McGovern Medical School and schools of biomedical informatics, biomedical sciences, dentistry and public health. UTHealth includes The University of Texas Harris County Psychiatric Center, as well as the growing clinical practices UT Physicians, UT Dentists and UT Health Services. The university’s primary teaching hospitals are Memorial Hermann-Texas Medical Center, Children’s Memorial Hermann Hospital and Harris Health Lyndon B. Johnson Hospital. For more information, visit http://www.uth.edu.

About the Evelyn H. Griffin Stem Cell Therapeutics Research Laboratory The Evelyn H. Griffin Stem Cell Therapeutics Research Laboratory, which is part of the Cellular Therapy Core at UTHealth, has been Immatics’ manufacturing partner since 2015. The site is a U.S. Food and Drug Administration (FDA)-registered and inspected cGMP facility that has received accreditation from the Foundation for Accreditation of Cellular Therapy (FACT) as well as certification from the Clinical Laboratory Improvement Amendment (CLIA) and the College of American Pathologists (CAP).

Forward-Looking Statements Certain statements in this press release may be considered forward-looking statements. Forward-looking statements generally relate to future events or Immatics’ future financial or operating performance. For example, statements concerning the timing of product candidates and Immatics’ focus on partnerships to advance its strategy are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as may”, should”, expect”, intend”, will”, estimate”, anticipate”, believe”, predict”, potential” or continue”, or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Immatics and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management's control including general economic conditions and other risks, uncertainties and factors set forth in filings with the Securities and Exchange Commission (SEC). Nothing in this presentation should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. Immatics undertakes no duty to update these forward-looking statements.

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Immatics Extends Cell Therapy Manufacturing Collaboration with UTHealth | 2020-08-06 | Press Releases - Stockhouse

Potential Impact of COVID-19 Pandemic on Global Stem Cell Assay Coronavirus Impact Editon of Key Companies Merck, Thermo Fisher Scientific, GE…

By Stem Cell Medicine

Report is a detailed study of the Stem Cell Assay market, which covers all the essential information required by a new market entrant as well as the existing players to gain a deeper understanding of the market.The primary objective of this research report named Stem Cell Assay market is to help making reliable strategic decisions regarding the opportunities in Stem Cell Assay market. It offers business accounts, industry investors, and industry segments with consequential insights enhancing decision making ability.nicolas.shaw@cognitivemarketresearch.com or call us on +1-312-376-8303.

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Global and Regional Stem Cell Assay Market Segmentation by Type: Viability, Purification, Identification

Global Stem Cell Assay Market Segmentation by Applications: Regenerative Medicine, Clinical Research

Major Market Players with an in-depth analysis: Merck, Thermo Fisher Scientific, GE Healthcare, Agilent Technologies, Bio Rad Laboratories, Promega, Cell Biolabs, PerkinElmer, Miltenyi Biotec, HemoGenix, Bio Techne, STEMCELL

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The Stem Cell Assay market report offers the current state of the market around the world. The report starts with the market outline and key components of the Stem Cell Assay market which assumes a significant job for clients to settle on the business choice. It additionally offers the key focuses to upgrade the development in the Stem Cell Assay market. Some fundamental ideas are likewise secured by reports, for example, item definition, its application, industry esteem chain structure and division which help the client to break down the market without any problem. Also, the report covers different factors, for example, arrangements, efficient and innovative which are affecting the Stem Cell Assay business and market elements.

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The research comprises primary information about the products. Similarly, it includes supply-demand statistics, and segments that constrain the growth of an industry. It also includes raw materials used and manufacturing process of Stem Cell Assay market. Additionally, report provides market drivers and challenges & opportunities for overall market in the particular provincial sections.

Competitive Analysis has been done to understand overall market which will be helpful to take decisions. Major players involved in the manufacture of Stem Cell Assay product has been completely profiled along with their SWOT. Some of the key players include Merck, Thermo Fisher Scientific, GE Healthcare, Agilent Technologies, Bio Rad Laboratories, Promega, Cell Biolabs, PerkinElmer, Miltenyi Biotec, HemoGenix, Bio Techne, STEMCELL. It helps in understanding their strategy and activities. Business strategy described for every company helps to get idea about the current trends of company. The industry intelligence study of the Stem Cell Assay market covers the estimation size of the market each in phrases of value (Mn/Bn USD) and volume (tons). Report involves detailed chapter on COVID 19 and its impact on this market. Additionally, it involves changing consumer behavior due to outbreak of COVID 19.

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Regional Analysis for Stem Cell Assay North America (United States, Canada) Europe (Germany, Spain, France, UK, Russia, and Italy) Asia-Pacific (China, Japan, India, Australia, and South Korea) Latin America (Brazil, Mexico, etc.) The Middle East and Africa (GCC and South Africa)

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Chapters Define in TOC (Table of Content) of the Report: Chapter 1: Market Overview, Drivers, Restraints and Opportunities, Segmentation Overview Chapter 2: COVID Impact Chapter 3: Market Competition by Manufacturers Chapter 4: Production by Regions Chapter 5: Consumption by Regions Chapter 6: Production, By Types, Revenue and Market share by Types Chapter 7: Consumption, By Applications, Market share (%) and Growth Rate by Applications Chapter 8: Complete profiling and analysis of Manufacturers Chapter 9: Manufacturing cost analysis, Raw materials analysis, Region-wise Manufacturing expenses Chapter 10: Industrial Chain, Sourcing Strategy and Downstream Buyers Chapter 11: Marketing Strategy Analysis, Distributors/Traders Chapter 12: Market Effect Factors Analysis Chapter 13: Market Forecast Chapter 14: Stem Cell Assay Research Findings and Conclusion, Appendix, methodology and data source To check the complete Table of Content click here: @ https://cognitivemarketresearch.com/medical-devicesconsumables/stem-cell-assay-market-report#table_of_contents

The qualitative contents for geographical analysis will cover market trends in each region and country which includes highlights of the key players operating in the respective region/country, PEST analysis of each region which includes political, economic, social and technological factors influencing the growth of the market. The research report includes specific segments by Type and by Application. This study provides information about the sales and revenue during the historic and forecasted period of 2015 to 2027.

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Potential Impact of COVID-19 Pandemic on Global Stem Cell Assay Coronavirus Impact Editon of Key Companies Merck, Thermo Fisher Scientific, GE...

Canine Stem Cell Therapy Market Analysis Of Growth, Trends Progress And Challenges Till Upcoming Year – Connected Lifestyle

By Stem Cell Treatment

The Canine Stem Cell Therapy market study offers an in-depth analysis of the current market trends influencing this business vertical. The study also includes market valuation, market size, revenue forecasts, geographical spectrum and SWOT Analysis of the industry. In addition, the report depicts key challenges and growth opportunities faced by the industry bigwigs, in consort with their product offerings and business strategies.

A collective analysis of Canine Stem Cell Therapy market offering an exhaustive study based on current trends influencing this vertical across various geographies has been provided in the report. Also, this research study estimates this space to accrue considerable income during the projected period, with the help of a plethora of driving forces that will boost the industry trends during the forecast duration. Snippets of these influences, in tandem with countless other dynamics relating to the Canine Stem Cell Therapy market, like the risks that are predominant across this industry along with the growth prospects existing in Canine Stem Cell Therapy market, have also been charted out in the report.

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Market Taxonomy

The global canine stem cell therapy market has been segmented into:

Product Type:

Application:

End User:

Region:

, according to the competitive hierarchy. These firms have been competing with one another to gain a near-dominant status in the industry.

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Canine Stem Cell Therapy Market Analysis Of Growth, Trends Progress And Challenges Till Upcoming Year - Connected Lifestyle

Global Stem Cell Therapy for Osteoarthritis Market Research Study 2020 Insights with COVID-19 Impact Analysis by 2020Mesoblast, Regeneus, U.S. Stem…

By Stell Cell Research

Rising number of corona virus cases has impacted numerous lives and led to numerous fatalities, and has affected the overall economic structure globally. The Stem Cell Therapy for Osteoarthritis has analyzed and published the latest report on the global Stem Cell Therapy for Osteoarthritis market. Change in the market has affected the global platform. Along with the Stem Cell Therapy for Osteoarthritis market, numerous other markets are also facing similar situations. This has led to the downfall of numerous businesses, because of the widespread increase of the number of cases across the globe.href=mailto:nicolas.shaw@cognitivemarketresearch.com>nicolas.shaw@cognitivemarketresearch.com or call us on +1-312-376-8303.

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The major players in the Stem Cell Therapy for Osteoarthritis market are Mesoblast, Regeneus, U.S. Stem Cell, Anterogen, Asterias Biotherapeutics . Some of the players have adopted new strategies to sustain their position in the Stem Cell Therapy for Osteoarthritis market. A detailed research study is done on the each of the segments, and is provided in Stem Cell Therapy for Osteoarthritis market report. Based on the performance of the Stem Cell Therapy for Osteoarthritis market in various regions, a detailed study of the Stem Cell Therapy for Osteoarthritis market is also analyzed and covered in the study.

Report Scope: Some of the key types analyzed in this report are as follows: Monotherapy, Combination Therapy

Some of the key applications as follow: Osteoarthritis (unspecified), Knee Osteoarthritis, Shoulder Osteoarthritis, Hip Osteoarthritis

Following are the major key players: Mesoblast, Regeneus, U.S. Stem Cell, Anterogen, Asterias Biotherapeutics

An in-depth analysis of the Stem Cell Therapy for Osteoarthritis market is covered and included in the research study. The study covers an updated and a detailed analysis of the Stem Cell Therapy for Osteoarthritis market. It also provides the statistical information of the Stem Cell Therapy for Osteoarthritis market. The study of the report consists of the detailed definition of the market or the overview of the Stem Cell Therapy for Osteoarthritis market. Furthermore, it also provides detailed information for the target audience dealing with or operating in this market is explained in the next section of the report.

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The report also provides detailed information on the research methodologies, which are used for the analysis of the Stem Cell Therapy for Osteoarthritis market. The methods are covered in detail in this section of the report. For the analysis of the market, several tools are used for the extraction of the market numbers. Among the several tools, primary and secondary research studies were also incorporated for the research study. These were further analyzed and validated by the market experts, to increase precision and make the data more reliable.

Moreover, the report also highlights and provides a detailed analysis of the drivers, restrains, opportunities, and challenges of the Stem Cell Therapy for Osteoarthritis market. This section of Stem Cell Therapy for Osteoarthritis market also covers the updated information, in accordance with the present situation of the market.

According to the estimation and the analysis of the market, the Stem Cell Therapy for Osteoarthritis market is likely to have some major changes in the estimated forecasts period. Moreover, these changes can be attributed to the changes due to economic and trading conditions across the globe. Moreover, several market players operating in the Stem Cell Therapy for Osteoarthritis market will have to strategically change their business strategies in order to survive in the market.

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Outlook on the Worldwide Hunter Syndrome Industry to 2030 – ResearchAndMarkets.com – Business Wire

By Stem Cell Treatment

DUBLIN--(BUSINESS WIRE)--The "Hunter Syndrome - Market Insights, Epidemiology and Market Forecast - 2030" drug pipelines has been added to ResearchAndMarkets.com's offering.

This report delivers an in-depth understanding of the Hunter Syndrome, historical and forecasted epidemiology as well as the Hunter Syndrome market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

The Hunter Syndrome market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Hunter Syndrome market size from 2017 to 2030. The report also covers current Hunter Syndrome treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.

Hunter Syndrome Diagnosis

The diagnosis of Hunter syndrome is established in a male by identifying the deficient iduronate 2-sulfatase (I2S) enzyme activity in white cells, fibroblasts, or plasma in the presence of normal activity of at least one other sulfatase. Detection of a hemizygous pathogenic variant in IDS confirms the diagnosis in a male with an unusual phenotype or a phenotype that does not match the results of GAG testing. The diagnosis of this indication is usually established in a female with suggestive clinical features by identification of a heterozygous IDS pathogenic variant on molecular genetic testing.

Although the disease is almost exclusively reported in males, rare cases in females also do occur. The diagnosis of MPS II is usually established in a female patient with suggestive clinical features, such as the identification of a heterozygous IDS pathogenic variant on molecular genetic testing.

Molecular genetic testing approaches can include a combination of gene-targeted testing (single-gene testing, multigene panel) and comprehensive genomic testing (exome sequencing, genome sequencing) depending on the phenotype. Gene-targeted testing requires that the clinician determine which gene(s) are likely involved, whereas genomic testing does not.

Hunter Syndrome Treatment

Even with the introduction of ERT, patients with MPS II still require supportive symptomatic treatment from a wide range of specialists. A comprehensive initial assessment of each patient at diagnosis should, therefore, be undertaken, and should be followed by regular reviews. Supportive management and the anticipation of possible complications can greatly improve the quality of life of affected individuals and their families. Family members should be offered genetic counselling, and contact with other affected families, patients, and support groups.

It is now a decade since ERT with intravenous idursulfase (Elaprase), a recombinant form of human iduronate 2-sulfatase, has been approved in the United States and the European Union at a weekly dose of 0.5 mg/kg for the treatment of MPS II. The approval was mainly based on the results from a first trial on individuals with the slowly progressive form of the disease. In the following year several other studies were undertaken to investigate clinical safety and efficacy of ERT; these clearly showed that idursulfase has positive effects on functional capacity (distance walked in six minutes and forced vital capacity), liver and spleen volumes, and urine GAGs excretion. Recently, a 3.5-year independent study determined that long-term use of ERT is similarly effective in young (age 1.6-12 years at the start of ERT) and older individuals (age 12-27 years at the start of ERT). In addition, two recent studies have confirmed ERT efficacy in improving somatic signs and symptoms of the disease in all individuals, including infants younger than age 1 year and individuals with the early progressive MPS II phenotype.

Pretreatment with anti-inflammatory drugs or antihistamines, as is often done for ERT in other conditions, is not suggested on the label for Elaprase; however, if mild or moderate infusion reactions (e.g., dyspnea, urticaria, or systolic blood pressure changes of 20 mm Hg) cannot be ameliorated by slowing the infusion rate, the addition of treatment one hour before infusion with diphenhydramine and acetaminophen (or ibuprofen) to the regimen usually resolves the problem. Pretreatment can typically be discontinued after 6-10 weeks.

Hematopoietic stem cell transplantation (HSCT) using umbilical cord blood or bone marrow is a potential way of providing sufficient enzyme activity to slow or stop the progression of the disease, however, the use of HSCT is controversial because of the associated high risk of morbidity and mortality. The use of HSCT has been controversial because of limited information regarding the long-term outcomes and the associated high risk of morbidity and mortality.

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Outlook on the Worldwide Hunter Syndrome Industry to 2030 - ResearchAndMarkets.com - Business Wire

Stem Cell Therapy Market Detail Analysis focusing on Application, Types and Regional Outlook – Bulletin Line

By Stell Cell Research

COVID-19 can influence the global economy in three ways: by directly influencing production and demand, by creating supply chain and market disruptions, and by having a financial impact on businesses and financial markets. The eruption of COVID-19 has implications for many aspects such as flight cancellations. Travel bans and quarantines; Restaurants closed; all Indoor Events restricted; over forty countries declared a state of emergency; massive supply chain slowdown; stock market volatility; falling business confidence, growing panic in the population and uncertainty about the future.

Competitive Landscape:

Stem Cell Therapy Market report highlights key players included in the market in order to render a comprehensive view of the competing players existing in the market. Company details, strategies, aptitude, history, cost analysis, and prevalent strategies. This section of the report identifies various key manufacturers of the market. It helps the reader understand the strategies and collaborations that players are focusing on combat competition in the market. The comprehensive report provides a significant microscopic look at the market. The reader can identify the footprints of the manufacturers by knowing about the global revenue of manufacturers, the global price of manufacturers, and Production by manufacturers during the forecast period of 2019 to 2026.

Regional analysis:

Geographically, the global Specialty Frozen Bakery market is divided into global regions like Europe, North America, Asia- Pacific, Middle East and Africa.

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This study analyses the growth of Stem Cell Therapy Market based on the present, past and futuristic data and will render entire information about the Internet Advertising industry to the market-leading industry players that will guide the direction of the Stem Cell Therapy Market through the forecast period. All of these players are analysed in detail to get details concerning their recent announcements and partnerships, product/services, investment strategies, and so on.

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Stem Cell Therapy Market Detail Analysis focusing on Application, Types and Regional Outlook - Bulletin Line

Research Report on Cell Theraputics Market by Current Industry Status, Growth Opportunities, Top Key Players, and Forecast to 2025 – AlgosOnline

By Stell Cell Research

This report provides a strategic analysis of the Global Cell Theraputics market and the growth estimates for the forecast period. This report also provides market sizing and forecasts for the Global Cell Theraputics market.

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The Cell Theraputics market report claims that the industry is predicted to account a significant revenue over the forecasted period. It consists of information related to the market dynamics such as challenges involved in this vertical, growth opportunities, and factors affecting the domain.

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Koepka’s biggest challenge is history in bid for 3 in a row – The Associated Press

By Stell Cell Research

Peter Thomson might have been up to his old tricks. He once described the Americans as the greatest collection of golfers in the world right before he captained an International team that annihilated the U.S. in the 1998 Presidents Cup.

So what to make of his prediction at Carnoustie nine years later? Tiger Woods was going for a third straight British Open title, a feat accomplished only six times in major championship history, most recently by Thomson in 1956.

He has a chance to win eight in a row, Thomson replied.

It wasnt clear if Thomson was joking or trying to create even more attention for Woods. By the end of the week, it was a moot point as Woods tied for 12th. Woods won majors at a faster clip than anyone. He remains the only player to win multiple majors in consecutive years. But he never won the same major three straight times.

Neither did Jack Nicklaus. The one chance he had, Nicklaus missed the cut going for a third straight Masters. Tom Watson shared the 54-hole lead at St. Andrews in 1984 in his bid for a third straight British Open. He closed with 73 and finished two shots behind Seve Ballesteros.

Arnold Palmer. Ben Hogan. Harry Vardon.

The list of failures is much longer than the six men who actually won the same major back-to-back-to-back.

Thats why the biggest challenge facing Brooks Koepka as he goes for a third straight PGA Championship this week at the TPC Harding Park in San Francisco is more about history than his troublesome left knee and recent form.

Its rare.

I just want to play good golf. Its simple, Koepka said when he went to Bay Area in February to preview a PGA Championship that was supposed to be held in May before the COVID-19 pandemic upended golfs calendar.

You start thinking about all the things that could happen, thats when nerve, everything else kind of creeps in. Just stay in the moment and keep plugging along.

Koepka already has had one crack at a three-peat and showed why he cant be overlooked. Trying to become the first player in more than a century to win the U.S. Open three straight times, he chased Gary Woodland all the way to the finish line at Pebble Beach and finished second.

Then it was all about Willie Anderson, the only player to win three straight U.S. Opens. Now its about Walter Hagen, who won the PGA Championship four straight times (1924-27) when it was match play.

Walter Hagen is a name every golf fan knows, Koepka said. To even have a chance to put my name with his would be incredible and it would be super special. ... Two-time defending, its a different feeling, and one you want to win this year.

Koepka won a thriller at Bellerive in 2018, when he set the PGA Championship scoring record at 264 and matched the lowest score at any major. He nearly blew a seven-shot lead last year at Bethpage Black before winning by two. It helped that he set the 36-hole record for all majors at 128 with what he calls the best golf he ever played.

But this isnt the same player. Koepka had stem cell treatment after last season because of a partially torn patella. Two weeks later, he slipped on a wet slab of concrete at the CJ Cup in South Korea and injured his left knee further, keeping him out for three months. And then he lost another three months to the pandemic.

He has gone a year without winning. Last week at the World Golf Championship, he said he is adjusting his swing to accommodate his left knee and Koepka had his best chance of winning, tied for the lead until hitting into the water off the tee on the final hole as Justin Thomas won.

For someone with this much history on the line, Koepka still has managed to avoid the spotlight in the weeks leading into the PGA Championship. Attribute that to the pandemic, and the PGA Tours return to golf two months ago in which positive tests eight so far get as much attention as birdies and bogeys.

Were in different times now, said Curtis Strange, part of the ESPN broadcast team who had his shot at three straight U.S. Opens in 1990. All sports have been put on the back burner just a little bit. I havent read a lot about it, and Ive talked a couple times to reporters about three in a row. ... But it would be a hell of an accomplishment.

That much is clear by the fact that no one has done it in 64 years. And when Thomson won his third straight British Open in 1956, it had been 29 years since Hagen, whose streak came 22 years after Andersons. The other three were from the 19th century Bob Ferguson (1880-82), Jamie Anderson (1877-79) and Young Tom Morris (1868-70) when only about 40 players competed in the British Open.

Woods has won at least three straight times at four PGA Tour events three in a row at Firestone and Memorial, four in a row at Torrey Pines and Bay Hill. Just not in the majors.

He has gone back-to-back in the Masters and British Open, and twice in the PGA Championship. He tied for 29th in the 2001 PGA in Atlanta. He tied for 15th in the 2003 Masters. He tied for 12th at Carnoustie. He never got a chance in 2008 because of season-ending knee surgery.

The Masters is the one major no one has won three straight times, and Woods knew it. He also knew the opportunity was rare. If youre ever in that position, you want to take advantage of it because it doesnt happen all the time, he said.

What happened?

He went 21 holes before making his first birdie. He opened with a 76, his worst start in a major. And he never had another shot at three straight Masters.

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Koepka's biggest challenge is history in bid for 3 in a row - The Associated Press

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