Automated Cell Culture Systems Market to Record Strong Growth due to High Demand for Advanced Treatment of Chronic Conditions, Future Market Insights…

Dubai, U.A.E, Aug. 3, 2020 /PRNewswire/ -- According to Future Market Insights, the automated cell culture systems marketwill exhibit a strong CAGR of 8% from 2020-2030.

Escalating incidences of chronic ailments have spurred greater research in cytology and cell biology for developing advanced diagnosis and treatment. This is largely an end-product of boundaries in conventional pharmaceuticals. Furthermore, growing complexities of the nature of chronic diseases is prompting various technological advancements with regard to treatment, thereby bolstering the scope of automated cell culture systems.

Greater penetration of 3D-cell cultures have significantly boosted the adoption of automated culture systems, as is the need for faster testing of biological or biochemical activities. Furthermore, requirement of cell lines to devise vaccines for COVID-19 shall catapult the automated cell culture market in the upcoming forecast period.

"Key players are developing specific and specialty growth media with the aid of various technological advancements, which is expected to sustain market growth over the following decade," infers an FMI analyst.

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Key Takeaways from FMI's Automated Cell Structure Systems Report

Automated Cell Culture Systems Market- Key Trends

Automated Cell Culture Systems Market- Region-wise Analysis

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Automated Cell Culture Systems Market- Competitive Landscape

Prominent players are concentrating on offering new products, innovations and collaborations with other companies to widen their outreach across major geographical areas.

For instance, in July 2020, Sphere Fluidics announced a partnership with the Heriot-Watt University in Edinburgh for developing next generation droplet generator instrumentation. This agreement is for expanding its advanced biologics discovery and therapeutic cell line development.

Also, in February 2020, Selexis announced the application of Bioprocessing 4.0 by incorporating automated systems such as the ambr and Beacon optofluidic platforms for enhanced cell line development.

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Automated Cell Culture Systems Market Taxonomy

Product Type

Cell Culture Type

Application

End User

Region/Country

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More Insights on the Automated Cell Culture Systems Market

The study provides compelling insights on automated cell culture systems market on basis of product type (automated cell culture storage equipment, automated cell culture vessels, bioreactors and consumables), cell culture type (finite cell line cultures, infinite cell line cultures), application (drug development, stem cell research, regenerative medicine and cancer research) and end user (biotech companies, research organizations, academic institutes), and across seven major regions.

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CarthroniX President/Chairman of the Board R. Rex Parris and Carrol Parris Donate $50,000 in Support of Life Extension Research – PRNewswire

LANCASTER, Calif., Aug. 3, 2020 /PRNewswire/ -- R. Rex Parris, President and Chairman of the Board of biotech company CarthroniX, announced a donation of $50,000 to Denis Evseenko, MD, Ph.D. of the Keck School of Medicine of USC to support continued research in the field longevity.

Dr. Evseenko was recently awarded a $1.69 million research project grant from the National Institutes of Health to address how to slow arthritis in aging joints. He has helped develop breakthroughs in molecular studies that identified and characterized the unique cell populations that form the superficial human joint cartilage zone.

Dr. Evseenko is one of the world's leading medical researchers of arthritis and how gene activity drives cartilage development. "The CDC reports that 23% of all adults, or 54 million people, have some form of arthritis and are limited in their activities due to severe joint pain," said Mr. Parris. "Dr. Evseenko's work will help tens of millions of people in this country and many more worldwide, living with arthritis's daily struggle. Now there is evidence that it will also extend the quality of life and longevity."

CarthroniX is comprised of scientists and surgeons with expertise in regenerative medicine and stem cell research. Their research is focused on creating novel small molecules to stimulate the regrowth of healthy cartilage. Dr. Evseenko's work fits seamlessly with CarthroniX's goals of extending the quality of life for millions of people. Osteoarthritis is one component of the aging process as cartilage degenerates over time, especially after injury and wear and tear.

Recently it was discovered that some of the small molecules studied to treat arthritis also reverse the aging of human cells in vitro. This gift will enable Dr. Evseenko's lab to advance to the next stage of research. The CX-1 small molecule will hopefully slow the aging of mice. If this is confirmed, CarthroniX will seek FDA approval of human trials to investigate CX-1's effect on human longevity and regeneration of vital organs. "This gift will help us explore some fundamental and transformative questions related to life span extension," said Dr. Evseenko.

CarthroniX novel technologies are proven to preserve, repair, and regenerate cartilage in joints and suppress inflammation in large animals. CarthroniX is developing two types of drugs: one that is both regenerative and anti-inflammatory, and a second that is solely anti-inflammatory.

ABOUT CarthroniX

CarthroniX is developing novel small molecules to stimulate the growth and regeneration of articular cartilage in joints. CarthroniX patented, first-in-class small molecule CX-1 activates an established regenerative pathway; they demonstrated this results in cartilage proliferation, cellular migration, and deposition of cartilaginous matrix.

Media Contact: Joe Marchelewski, [emailprotected]

SOURCE PARRIS Law Firm

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CarthroniX President/Chairman of the Board R. Rex Parris and Carrol Parris Donate $50,000 in Support of Life Extension Research - PRNewswire

UPDATE – Cytovia Therapeutics Acquires Worldwide Rights to CytoImmune Therapeutics’ First-In-Class EGFR Dual-targeting CAR for NK Cell Treatment of…

August 03, 2020 15:36 ET | Source: Cytovia Therapeutics

NEW YORK and MONROVIA, Calif., Aug. 03, 2020 (GLOBE NEWSWIRE) -- Cytovia Therapeutics, Inc (Cytovia), an emerging biopharmaceutical company developing natural killer (NK) immunotherapies for cancer, today announces that it has acquired worldwide rights from CytoImmune Therapeutics for its novel EGFR Dual-targeting CAR to be used for NK cell therapy. Cytovia will conduct and finance all future development and will apply the EGFR Dual-targeting CAR to its iPSC CAR NK technology. CytoImmune will receive an upfront equity grant in Cytovia, future development milestones, and royalties.

Dr. Daniel Teper, Chairman and CEO of Cytovia added: We are honored to collaborate with Dr. Caligiuri, a pioneer in translating biological research on NK cells into impactful therapeutics. He has published solid data with intracranial injection of EGFR CAR NK cells to support their clinical development in glioblastoma. Additionally, EGFR is a clinically validated target which will allow us to expand the use of NK cellular therapy in multiple solid tumors.

Pre-clinical proof of concept data with intracranial administration of the EGFR Dual-targeting CAR-NK cells for the treatment of glioblastoma has been published in Nature Scientific Reports. The EGFR Dual-targeting CAR targets glioblastoma cells expressing EGFR wild-type and/or the mutant EGFR vIII. A single intracranial injection of EGFR CAR NK cells reduced the growth of glioblastoma and showed a statistically significant improvement in survival in animal models. The intracranial injection of the EGFR CAR NK cells remained localized in the brain without entering the systemic circulation or infiltrating extracranial organs or tissues, thus limiting toxicity.

Michael A. Caligiuri, MD, the scientific founder of CytoImmune, has been invited and is planning to join the Cytovia Scientific Advisory Board. Dr Caligiuri is the Deana and Steve Campbell Physician in Chief Distinguished Chair and President of the City of Hope National Medical Center in Duarte, CA. Dr. Caligiuri is a world-renowned physician, scientist, builder, innovator, leader and visionary. He was elected a Member of the National Academy of Medicine for his work on NK cell biology and its clinical applications. He is a past President of the American Association for Cancer Research (AACR).

Dr Caligiuri commented: CAR NK cell therapy has the potential to transform cancer outcomes. We are excited to partner with Cytovia to rapidly bring EGFR Dual-targeting CAR NK cells, a next generation therapy, to patients with the ultimate goal of curing glioblastoma. Cytovias off-the-shelf iPSC CAR NK cell technology should increase the access to precision immunotherapy for many cancer patients.

ABOUT CAR NK CELL THERAPYChimeric Antigen Receptors (CAR) are fusion proteins that combine an extracellular antigen recognition domain with an intracellular co-stimulatory signaling domain. Natural Killer (NK) cells are modified genetically to allow insertion of a CAR. CAR NK cell therapy has demonstrated initial clinical relevance without the limitations of CAR-T, such as Cytokine Release Syndrome, neurotoxicity or Graft vs Host Disease (GVHD). Induced Pluripotent Stem Cells (iPSC) - derived CAR NKs are naturally allogeneic, available off-the-shelf and may be able to be administered on an outpatient basis. Recent developments with iPSC, an innovative technology, allow large quantities of homogeneous genetically modified CAR NK cells to be produced from a master cell bank, and thus hold promise to expand access of cell therapy for many patients.

ABOUT GLIOBLASTOMAGlioblastoma affects 290,000 new patients every year worldwide. Chemotherapy and radiotherapy lack specificity and provide limited efficacy along with high toxicity. The median overall survival from the time of diagnosis is only 14.6 months. Systemic and particularly intracranial or intratumoral immunotherapy, which can target localized and infiltrating cells, has shown initial promise in early clinical trials.

ABOUT CYTOVIA THERAPEUTICS, INC Cytovia Therapeutics Inc is an emerging biotechnology company that aims to accelerate patient access to transformational immunotherapies, addressing several of the most challenging unmet medical needs in cancer and severe acute infectious diseases. Cytovia focuses on Natural Killer (NK) cell biology and is leveraging multiple advanced patented technologies, including an induced pluripotent stem cell (iPSC) platform for CAR (Chimeric Antigen Receptors) NK cell therapy, next-generation precision gene-editing to enhance targeting of NK cells, and NK engager multi-functional antibodies. Our initial product portfolio focuses on both hematological malignancies such as multiple myeloma and solid tumors including hepatocellular carcinoma and glioblastoma. The company partners with the University of California San Francisco (UCSF), the New York Stem Cell Foundation (NYSCF) and the Hebrew University of Jerusalem. Learn more atwww.cytoviatx.com

ABOUT CYTOIMMUNE THERAPEUTICS CytoImmune Therapeutics (CytoImmune) is biotechnology company focused on the application of proprietary chimeric antigen receptors (CAR) for use in both off-the-shelf human natural killer (NK) cells and autologous cytotoxic effector T cells in the treatment of liquid and solid tumors. Our CoalesceNT platform harnesses the power of both a specific CAR and a different secretory bispecific antibody in a single construct to coordinate an immune response with CAR NK cells, cytolytic effector T cells, NK-T cells and g/d T cells. This combination of NK- and T-cell therapy expedites time-to-treatment and delivers a dynamic response that reflects both innate and adaptive immunity in an effort to reduce tumor evasion and the incidence of cancer recurrence.

Learn more at http://www.cytoimmune.com

Contact for media enquiries Sophie Badr Vice President, Corporate Affairs Sophie.badre@cytoviatx.com 1(929) 317 1565

Will Rossellini President will@cytoimmune.com 1(469) 222 2350

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UPDATE - Cytovia Therapeutics Acquires Worldwide Rights to CytoImmune Therapeutics' First-In-Class EGFR Dual-targeting CAR for NK Cell Treatment of...

FDA-approved treatment puts rare cancer with skin manifestations on the map – Dermatology Times

A small group of scientists and clinicians are trying to build awareness of this cancer, and how to diagnose and treat it. While this rare and aggressive hematologic malignancy hasnt had a standardized therapeutic approach in the past, that is also changing. The FDA approved tagraxofusp (Elzonris, Stemline) in 2019 as the first medication indicated to treat BPDCN, according to a drug review published June 24, 2020 in the journal Expert Review of Anticancer Therapy.1

Progress aside, theres still a long way to go in creating awareness among dermatologists, primary care physicians, emergency department providers and pediatricians all of whom are most likely to encounter people with possible BPDCN, says Naveen Pemmaraju,M.D., associate professor in the department of leukemia at The University of Texas MD Anderson Cancer Center. Dr. Pemmaraju is senior author on the recent Expert Review of Anticancer Therapy paper, and he led the pivotal study published in April 2019 in the New England Journal of Medicine that led to the FDAs approval of tagraxofusp for the treatment of BPDCN.2

Having the clinical trial is great, but now that the drug is commercially available there was a call for what are the practical considerations for Tagraxofusp in BPDCN? Dr. Pemmaraju says. Thats why we wrote this paper.

Dermatologists, take noteDr. Pemmaraju points to three stand-out practical considerations for providers.

One is that most people in medicine have yet to even hear about the disease, he says. When people on the frontlines see skin lesions, the only way theyre going to know whether its BPDCN is with a biopsy. Tissue is the issue, as they say. If something looks irregular, abnormal and if its clinically indicated to do a biopsy, do a biopsy. A lot of these patients get mistaken for other diseases, infections, other cancers. So, I think the biopsy is important.

The need for expert review goes along with the first practical consideration.

CD123 (interleukin-3 receptor alpha unit) is overexpressed in 100% of BPDCN patients. But thats not the only way to differentiate this cancer on biopsy. CD123, CD4, CD56 as the golden triad of BPDCN, according to Dr. Pemmaraju.

Now we know there are other markers, TCL1, TCF 4, CD303 and others. When you put together these three to six markers, it helps you distinguish BPDCN, which is extraordinarily rare compared to the more common cancers like acute myeloid leukemia (AML), cutis, cutaneous t-cell lymphoma. Obviously, this differentiates completely from skin infections and all these other noncancer entities, Dr. Pemmaraju says.

The second practical consideration is that, although rare diseases commonly have limited-to-no treatment options, a therapy for BPDCN exists and more are being investigated. Studies suggest that BPDCN incidence is as low as 0.44% of all hematologic cancers and 0.7% of cutaneous lymphomas, according to the paper. Despite the low numbers, BPDCN treatment is available with tagraxofusp. Researchers are also conducting multiple clinical trials for BPDCN drugs in development, including the B-cell lymphoma-2 (BCL-2) inhibitor, venetoclax, and a chimeric antigen receptor (CAR) T-cell therapy.

The third consideration: The significance of dermatologists and dermatopathologists roles in BPDCN diagnosis.

As we educate our fellow hematologists/oncologists, we must continue to educate dermatologists, many of whom are going to see this disease for the very first time in the clinic before anybody else. I believe BPDCN will soon appear on dermatology and derm-path board exams, Dr. Pemmaraju says.

BPDCN skin lesions usually present as dark and purplish and can be maculopapular.

I would say clinically there is a somewhat distinct look, although I would add the caveat that these lesions act heterogeneously, he says.

Focusing on TagraxofuspResearchers reported that tagraxofusp, aCD123-directed cytotox, demonstrated efficacy in BPDCN patients along with an overall manageable safety profile, according to the NEJM study.

A historically deadly disease, BPDCNs median overall survival after chemotherapy had been 8 to 14 months, according to Dr. Pemmaraju. Hematopoietic stem cell transplant might prolong survival in patients healthy enough to have the stem cell transplant.

Among the 29 previously untreated patients, the survival rates of 59% at 18 months and 52% at 24 months rates that were influenced by the number of patients who went into remission after tagraxofusp therapy and could thus undergo hematopoietic stem-cell transplantation represent an improvement over rates in historically published data. We also observed a 67% overall response rate among previously treated patients. Notably, we report a meaningful survival with tagraxofusp among patients with relapsed or refractory disease (median overall survival, 8.5 months), Dr. Pemmaraju and colleagues report in the NEJM.

Interestingly, patients skin lesions went away rapidly in the vast majority of people treated with tagraxofusp, according to Dr. Pemmaraju.

Capillary leak syndrome emerged as the most drug-associated serious adverse, manifested by edema, tachycardia, hypoalbuminemia and hypotension.

There also is the issue of drug resistance. Researchers have found, in vivo, that resistance to tagraxofusp in cell lines is associated with decreased DPH1 expression and azacitadine might reverse tagraxofusp resistance.

More research is needed to study how combining tagraxofusp with other targeted therapies may improve outcomes. Research also is needed to study tagraxofusp use in pediatric patients. The FDAs approval is for tagraxofusp is as first-line therapy for BPDCN for adults and children ages 2 years and older. But only a small number of pediatric patients have been treated so far, the authors report.

DisclosureMD Anderson funded the study. Dr. Pemmaraju has received research funding/clinical trials support from Affymetrix, SagerStrong Foundation, Novaris, Stemline, Samus, AbbVie, Cellectis, Daiichi Sankyo, and Plexxikon.

References

1. Lee SS, Mccue D, Pemmaraju N. Tagraxofusp as treatment for patients with blastic plasmacytoid dendritic cell neoplasm. Expert Rev Anticancer Ther. 2020;:1-8.

2. Pemmaraju N, Lane AA, Sweet KL, et al. Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm. N Engl J Med. 2019;380(17):1628-1637.

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FDA-approved treatment puts rare cancer with skin manifestations on the map - Dermatology Times

Stem Cell Assay Market To 2026: Growth Analysis By Manufacturers, Regions, Types And Applications – Research Newspaper

The Stem Cell Assay Market report includes overview, which interprets value chain structure, industrial environment, regional analysis, applications, market size, and forecast. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. The report provides an overall analysis of the market based on types, applications, regions, and for the forecast period from 2020 to 2026. It also offers investment opportunities and probable threats in the market based on an intelligent analysis.

This report focuses on the Global Stem Cell Assay Market trends, future forecasts, growth opportunities, key end-user industries, and market players. The objectives of the study are to present the key developments of the market across the globe.

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Key List Market Participants in the Market: GE Healthcare Promega Corporation Thermo Fisher Scientific Merck KGaA Cell Biolabs Hemogenix

By Types: Viability Purification Identification

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By Regions: North America (The USA, Canada, and Mexico) Europe (Germany, France, the UK, and Rest of Europe) Asia Pacific (China, Japan, India, and Rest of Asia Pacific) Latin America (Brazil and Rest of Latin America.) Middle East &Africa (Saudi Arabia, the UAE, South Africa, and Rest of Middle East & Africa).

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About DataIntelo: DATAINTELO has set its benchmark in the market research industry by providing syndicated and customized research report to the clients. The database of the company is updated on a daily basis to prompt the clients with the latest trends and in-depth analysis of the industry. Our pool of database contains various industry verticals that include: IT & Telecom, Food Beverage, Automotive, Healthcare, Chemicals and Energy, Consumer foods, Food and beverages, and many more. Each and every report goes through the proper research methodology, validated from the professionals and analysts to ensure the eminent quality reports.

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More on the language of immunity – Cosmos

This continues the process from last week (the I essay) of introducing terms that will be encountered as we engage with the complexities of immunity. Ive bolded a few words and phrases that, while some may be commonplace, will be used in an unfamiliar context. Repertoire is in that category.

Repertoire is mainly owned by the entertainment and performance cultures. The repertoires of: an opera singer or solo instrumentalist; amazing strokes from a top tennis player; tricky moves by a spin bowler; and the playlist that defines the repertoires of both actors and a theatrical company like Bell Shakespeare or the fictional Good Companions in JB Priestleys novel. What were discussing here is a diversity of selected repertoires, with that selection being made first by the performers on the basis of their specific abilities and interests, then by those who care to engage by listening, buying tickets and attending an event as part of their target audience. The audience for, say, the latest Opera Australia production of Don Giovanni at Sydney Opera House will, though there may be some crossover, be largely different from that enjoying live music at a Kings Cross night club.

Immunologists use repertoire in discussing the extraordinary diversity of the adaptive immune system (See Immuno and the Red and the white essays) that has evolved to limit the damage caused by pathogens as different as measles virus and malaria. When it comes to any individual infection, what we are talking about is, in fact, three quite distinct repertoires that incorporate a diversity of highly specific recognition molecules, or receptors, expressed on three very distinct categories of immune white blood cells (WBCs) that do very different jobs in protecting us. Each cell, or lymphocyte (the terms are interchangeable here), within these populations of immune performers expresses only one highly specific receptor that, with its feet anchored firmly in the outer membrane of the cell, is made up of two protein chains. At the outer tip of these molecules, we find individually unique but enormously varied structural motifs (styles?) that bind to one or other target induced by the infectious process, in this case by SARS-CoV-2.

Taking the human performer analogy, it is these targets (we call them antigens in immunology) that are the audience selecting a high-performance repertoire from the enormous pool of possible candidates that live within each and every one of us, just as the nine billion or so human beings on our planet are the precursor pool for the top musicians and sports people selected by target audiences. Fans pay money to see them because they have great regard, or affinity for what they do. The central principle of specific immunity is that high affinity binding of an individual cell surface receptor to a particular target antigen leads to its incorporation in a selected response repertoire.

The three categories of immune lymphocytes that concern us here are the B cells, the CD4+ helper T cells and the CD8+ killer T cells. The B refers to a weird organ in birds called the Bursa of Fabricius where nave, or precursor, B cells first develop and start to express their surface receptors, the B cell receptors (BCRs). Mammals like us dont have that bursa (which has nothing to do with bursitis,) but we think that the same type of process goes on in our bone marrow (BM).

The T refers to the thymus, the organ in the neck that is large in children and gets smaller (involutes) as we age. BM stem cells travel to the thymus via the blood, where they multiply, differentiate and express the T cell receptors (TCRs) that direct the attention of the CD4+ T helpers and CD8+ T killers. After exiting the thymus into the blood, these nave T cell pools provide the narrow, antigen-selected repertoires that coalesce after infection or vaccination.

The CD of CD4 and CD8 is short for cluster of differentiation and is just part of a classification scheme for molecules on the surface of immune cells. Currently, there are 371 members in this molecular club some of which are differentially expressed on the surface of antigen-selected immune T cells (and B cells) as they multiply, then go down different functional pathways. These CD activation markers allow us to characterise distinct CD4+ and CD8+ T cell subsets.

The BCRs on naive B cells are an early form of the immunoglobulin (Ig), or antibody molecules that we met last week. By the time the Igs are being secreted by the B cell descendants, the large protein factory plasma cells, the BCRs will have been refined and changed by a process called affinity maturation that is unique for the B cell/plasma cell lineage and does not happen for the T cells. More of that later.

The CD4+ T helpers are, if you use the performer analogy, the agents and promotors of immunity. The CD8+ T killers are the assassins, the killers within that sounds a bit dangerous, but they are very important. Enough for now!

This article is the latest in theSetting it Straightseries written by Laureate ProfessorPeter Dohertyfrom Australias University of Melbourne and Doherty Institute to explain aspects of the evolving COVID-19 pandemic. You can read them allhere.

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More on the language of immunity - Cosmos