Global Cell Expansion Market, Forecast to 2025 – Increasing Incidence of Chronic Diseases and Government Investments for Cell-based Research – Yahoo…

DUBLIN, July 30, 2020 /PRNewswire/ -- The "Cell Expansion Market by Product (Reagent, Media, Flow Cytometer, Centrifuge, Bioreactor), Cell Type (Human, Animal), Application (Regenerative Medicine & Stem Cell Research, Cancer & Cell-based Research), End-User, and Region - Global Forecast to 2025" report has been added to ResearchAndMarkets.com's offering.

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The global cell expansion market is projected to reach USD 30.06 billion by 2025 from an estimated USD 14.91 billion in 2020, at a CAGR of 15.1%.

The report segments the cell expansion market based on region (Asia Pacific, Europe, North America, and RoW), product (consumables and instruments), cell type (human cells and animal cells), application (regenerative medicine and stem cell research, cancer and cell-based research and other applications), and end user (research institutes, biotechnology and biopharmaceutical companies, cell banks, and other end users). The report also provides a comprehensive review of market drivers, restraints, and opportunities in the cell expansion market.

Increasing incidence of chronic diseases and government investments for cell-based research are set to drive the cell expansion market

Growth in this market is largely driven by the increasing incidence of chronic diseases, government investments for cell-based research, growing focus on personalized medicine, increasing focus on R&D for cell-based therapies, and increasing GMP certifications for cell therapy production facilities. On the other hand, ethical concerns regarding research in cell biology are expected to limit market growth to a certain extent in the coming years.

By instruments type, the cell expansion supporting equipment accounted for the fasted growing product segment of the cell expansion market

The instruments segment includes cell expansion supporting equipment, bioreactors, and automated cell expansion systems. The cell expansion supporting equipment market includes flow cytometers, cell counters and hemocytometers, centrifuges, and other supporting equipment. They are used in cell culture processes for isolating, culturing, scaling-up, and extracting biological products. These instruments are essential in laboratories and institutes for conducting research and analyzing the cell structure and function for cell therapy research.

By cell type, the human cells segment accounted for the largest share of the cell expansion market

Based on cell type, the cell expansion market is segmented into human cells and animal cells. The human cells segment includes stem cells and differentiated cells. The stem cells segment is further classified into adult stem cells, ESCs, and iPSCs. The human cells segment accounted for the larger share of the cell expansion market majorly due to the increasing investments by public and private organizations for research on human cells, growing application areas of human stem cells, and the growing incidence of diseases such as cancer.

Asia Pacific: The fastest-growing region in the cell expansion market

The Asia Pacific market is projected to grow at the highest CAGR during the forecast period, mainly due to the increasing focus of players on emerging Asian markets, increasing incidence of chronic and infectious diseases, rising geriatric population, and government initiatives for infrastructural improvements of healthcare facilities are driving the growth of the cell expansion market in this region.

North America: the largest share of the cell expansion market

North America accounted for the largest share of the cell expansion market. The large share of this segment can primarily be attributed to the rising incidence of cancer, increasing government funding, rising research activates on stem cell therapies, growing awareness regarding advanced treatment methods, growing geriatric population, and the strong presence of industry players in the region.

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Global Cell Expansion Market, Forecast to 2025 - Increasing Incidence of Chronic Diseases and Government Investments for Cell-based Research - Yahoo...

UW researchers devise approach to treat rare, incurable form of blindness – University of Wisconsin-Madison

Scientists at the University of WisconsinMadison have published a proof-of-concept method to correct an inherited form of macular degeneration that causes blindness, and that is currently untreatable.

Andrew Hellpap 608-225-5024 ahellpap@uwhealth.org

The researchers were able to correct the disease in stem cells from patients with BEST1 mutations by overwhelming broken copies of the gene with many functional copies of BEST1. This approach worked for most, but not all, of the BEST1 mutations that they tested. As an alternative approach for mutations that did not respond to this gene augmentation method, the team used CRISPR-Cas9 gene editing to target and correct the mutations.

A paper chronicling the research, co-led by David Gamm, MD, PhD, professor of ophthalmology and visual sciences in the School of Medicine and Public Health, was published online July 23 in the American Journal of Human Genetics. The study was also led by Kris Saha, PhD, associate professor of biomedical engineering and Wisconsin Institute for Discovery, and Bikash Pattnaik, PhD, assistant professor of pediatrics.

This BEST1 gene encodes a protein that regulates the movement of chloride across a layer of the retina called the retinal pigment epithelium (RPE). Best disease is dominant, meaning that people who inherit only one faulty copy of the BEST1 gene from either their mother or their father will develop the disorder. Mutations in BEST1 cause the retinal layer to break down, resulting in blurred central vision that progresses to irreversible vision loss.

People with Best disease have a wide range of mutations that can affect different parts of the protein, all of which were thought to require complex, individualized gene therapies to fix them, Gamm said. We found that many of these mutations were actually very sensitive to a broader gene therapy method that is already established for other retinal diseases.

Fixing a dominant genetic disease via gene therapy typically requires precise removal or repair of the nonfunctional gene without causing harm to the functional gene a difficult task that is frequently unsuccessful. In contrast, recessive genetic diseases that arise when a person inherits two nonfunctional genes one from each parent can be corrected by a technique called gene augmentation. This well-established process introduces a functional copy of the gene to fill the void.

To use another analogy, dominant mutations produce workers that actively look to sabotage the efforts of their capable coworkers, whereas recessive mutations produce proteins that never show up for work at all, Gamm said. As it turns out, the latter situation is usually simpler to treat than the former.

A team of researchers at the McPherson Eye Research Institute, which Gamm directs, hypothesized that it may be possible to adequately dilute the influence of the nonfunctional BEST1 protein by counter-balancing it with many functional copies of BEST1 protein through gene augmentation.

In the lab, the approach worked in RPE cells derived from induced pluripotent stem cells of patients with most, but not all, of the BEST1 gene mutations they tested. Where gene augmentation did not succeed, the team was able to correct the dysfunction using CRISPR-Cas9 gene editing.

The research was carried out in large part by Divya Sinha, PhD, an assistant scientist in Gamms lab, Ben Steyer, a former MD-PhD student in Sahas lab, and Pawan Shahi, PhD, postdoctoral research associate in Pattnaiks lab. The research team also included Sushmita Roy, PhD, associate professor of biostatics and medical informatics at the UW School of Medicine and Public Health and Wisconsin Institute for Discovery.

The scientists demonstrated that their two-pronged gene therapy strategy may hold potential to treat all Best disease mutations in a highly effective manner.

We were able to reverse the disease in all the cell lines using one method or the other, Gamm said. We were also able to determine which mutations were likely to respond to the first-line gene augmentation strategy, and which would be better served with the second-line gene editing approach.

An additional benefit came into focus as this research progressed, according to Gamm.

Our findings also could be applicable to some dominant genetic mutations that affect tissues elsewhere in the body, he said. Its very exciting.

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UW researchers devise approach to treat rare, incurable form of blindness - University of Wisconsin-Madison

A Year After Getting Gene Therapy, Boys With Muscular Dystrophy Are Healthier and Stronger – Singularity Hub

Two and a half years ago, a study published in Science Advances detailed how the gene editing tool CRISPR/Cas-9 repaired genetic mutations related to Duchenne Muscular Dystrophy (DMD). The study was a proof of concept, and used induced pluripotent stem cells (iPSCs).

But now a similar treatment has not only been administered to real people, it has worked and made a difference in their quality of life and the progression of their disorder. Nine boys aged 6 to 12 who have been living with DMD since birth received a gene therapy treatment from pharmaceutical giant Pfizer, and a year later, 7 of the boys show significant improvement in muscle strength and function.

Though the treatments positive results are limited to a small group, theyre an important breakthrough for gene therapy, and encouraging not just for muscular dystrophy but for many other genetic diseases that could soon see similar treatments developed.

DMD is a genetic disorder that causes muscles to progressively degenerate and weaken. Its caused by mutations in the gene that makes dystrophin, a protein that serves to rebuild and strengthen muscle fibers in skeletal and cardiac muscles. As the gene is carried on the X chromosome, the disorder primarily affects boys. Many people with DMD end up in wheelchairs, on respirators, or both, and while advances in cardiac and respiratory care have increased life expectancy into the early 30s, theres no cure for the condition.

The gene therapy given to the nine boys by Pfizer was actually developed by a research team at the UNC Chapel Hill School of Medicineand it took over 30 years.

The team was led by Jude Samulski, a longtime gene therapy researcher and professor of pharmacology at UNC. As a grad student in 1984, Samulski was part of the first team to clone an adeno-associated virus, which ended up becoming a leading method of gene delivery and thus crucial to gene therapy.

Adeno-associated viruses (AAVs) are small viruses whose genome is made up of single-stranded DNA. Like other viruses, AAVs can break through cells outer membranesespecially eye and muscle cellsget inside, and infect them (and their human hosts). But AAVs are non-pathogenic, meaning they dont cause disease or harm; the bodies of most people treated with AAVs dont launch an immune response, because their systems detect that the virus is harmless.

Samulskis gene therapy treatment for DMD used an adeno-associated virus to carry a healthy copy of the dystrophin gene; the virus was injected into boys with DMD, broke into their muscle cells, and replaced their non-working gene.

Samulski said of the adeno-associated virus, Its a molecular FedEx truck. It carries a genetic payload and its delivering it to its target. The company Samulski founded sold the DMD treatment to Pfizer in 2016 so as to scale it and make it accessible to more boys suffering from the condition.

A year after receiving the gene therapy, seven of nine boys are showing positive results. As reported by NPR, the first boy to be treated, a nine-year old from Connecticut, saw results that were not only dramatic, but fast. Before treatment he couldnt walk up more than four stairs without needing to stop, but within three weeks of treatment he was able to run up the full flight of stairs. I can run faster. I stand better. And I can walk [] more than two miles and I couldnt do that before, he said.

The muscle cells already lost to DMD wont grow back, but the treatment appears to have restored normal function of the protein that fixes muscle fibers and helps them grow, meaning no further degeneration should take place.

Gene therapy trials are underway for several different genetic diseases, including sickle cell anemia, at least two different forms of inherited blindness, and Alzheimers, among others. Its even been used as part of cancer treatment.

Its only been a year, we dont yet know whether these treatments may have some sort of detrimental effect in the longer term, and the treatment itself can still be improved. But all of that considered, signs point to the DMD treatment being a big win for gene therapy.

Before it can be hailed as a resounding success, though, scientists feel that a more extensive trial of the therapy is needed, and are working to launch such a trial later this year.

Image Credit: pixelRaw from Pixabay

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A Year After Getting Gene Therapy, Boys With Muscular Dystrophy Are Healthier and Stronger - Singularity Hub

Qkine bolsters top team in first phase of scale-up – Business Weekly

Qkine a Cambridge-based specialist developer and manufacturer of proteins for stem cell, organoid and regenerative medicine applications has begun scaling following its recent fundraising round.

It has made key hires with the appointments of Rob Nixon as head of Commercial to its management team and Dr Cassie Doherty, investment director at Parkwalk, to its board.

With years of experience working with fast-growing biotechs and life science reagent suppliers, these appointments will be key to supporting the scale-up of Qkines commercial operations globally and expansion of its product development pipeline.

Nixon will implement the scale-up of the companys commercial strategy globally whilst building and leading Qkines growing commercial team. He has extensive commercial experience in the life science sector, having worked for world-leading global life science reagent companies Merck Millipore and GE Healthcare Life Science, as well as emerging, fast-growing startup Jellagen.

His experience in building and coaching highly successful sales teams, implementing go-to-market strategies and developing global distributor networks across the stem cell, organoid and regenerative medicine markets will accelerate the expansion of Qkines commercial operations across both existing and new markets.

Nixon said: There is a clear need in the stem cell culture and organoid research space for innovation. Customers are looking for expertise to improve growth factor biochemical quality, allowing for more reproducible and scalable manufacture of these core proteins to address the tremendous growth of these areas of research.

Dr Doherty becomes a non-executive director following Q Kines 1.5m series A investment round in June, which was led by Parkwalk. Her background in biochemistry and molecular biology, combined with over 10 years of extensive experience in life science investment, will be key to Qkine moving forwards as will her active style when it comes to supporting portfolio companies; advising on strategy, technical and commercial plans as Qkine continues to scale.

To date, companies Dr Doherty has worked with have cumulatively raised over 50 million in investment and she has been involved in many M & A and licensing deals.

She said: Qkines products fill a market need for high-quality protein reagents and clearly address problems that I have seen in companies working in the regenerative medicine, organoid and stem cell space.

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Qkine bolsters top team in first phase of scale-up - Business Weekly

Global Regenerative Medicine Market 2020| Industry Demand, Share, Global Trend, Industry News, Business Growth, Top Key Players Update, Business…

Global Regenerative Medicine Market industry is anticipated to an extensive growth during the forecast period 2018-2023. Regenerative Medicine Market report provides in detail analysis of market with revenue growth and upcoming trends. report contains the forecasts, market size, share estimates and profiles of the leading industry Players.

Regenerative Medicine Market research report provides derived key statistics, based on the market status of the manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the Regenerative Medicine industry. The report is a reliable analysis of current scenario of the market, which covers several market dynamics.

Get a Sample Copy Of The Report At https://www.absolutereports.com/enquiry/request-sample/13100563

The global regenerative medicine market has been estimated to reach USD 4.23 billion in 2023. The market is expected to register a CAGR of 14% during the forecast period 2018 to 2023. North America dominates the market due to the increasing technological advancements.

Increasing adoption of stem cell technology

Increasing adoption of stem cell technology, increasing prevalence of chronic diseases, emerging applications of gene therapy in regenerative medicine are some of the driving factors for Global Regenerative Medicine market. Technological advances in regenerative medicine (stem cell, tissue engineering, and nanotechnology) and high investment & funding to support development of regenerative medicine are also fuelling the market growth.

Regulatory and ethical issues

Regulatory and ethical issues pertaining stem cell, tissues engineering and regenerative medicine are acting as a restraint for Regenerative Medicine market. High cost of treatments and less awareness about the regenerative medicine among people is further restraining the market.

North America to Dominate the Market

The Regenerative Medicine market is segmented by type of treatment and geography. By geography it is segmented into North America, Europe, Asia-Pacific, the Middle East and Africa and South America. North America dominates the Regenerative Medicine market due to the increasing technological advancements and high investment & funding to support development of regenerative medicine. Asia-Pacific is also expected to propel the Regenerative Medicine market owing to factors, such as increasing accessibility to healthcare facilities in the region, and increasing economic growth.

Key Developments in the market

In January, 2018: Medeor Therapeutics Awarded $18.8 Million From the California Institute for Regenerative Medicine In January, 2018: RepliCel Life Sciences Inc. formed a partnership with the private firm, China-based Yofoto Health Industry Co. Ltd for regenerative medicine

Major Key Players: ACELITY, OSIRIS THERAPEUTICS, INC., INTEGRA LIFESCIENCES CORPORATION, ASTRAZENECA, COOK BIOTECH INCORPORATED, ORGANOGENESIS INC. and MERCK & CO., INC. etc.

Major Regions: US, Canada, Rest of North America, China, Japan, India, Rest of Asia-Pacific, Germany, UK, France, Rest of Europe, Brazil, South Africa, Rest of the World,

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Major Points Covered in Table of Content of Regenerative Medicine Market forecast 2023

1. Introduction of Regenerative Medicine Market Report

1.1 Study Deliverables

1.2 General Study Assumptions

2. Research Methodology

2.1 Introduction

2.2 Analysis Methodology

2.3 Study Phases

2.4 Econometric Modelling

3. Executive Summary

4. Market Overview and Regenerative Medicine Market Trends

4.1 Introduction

4.2 Market Trends

4.3 Porters Five Force Framework

4.3.1 Bargaining Power of Suppliers

4.3.2 Bargaining Power of Consumers

4.3.3 Threat of New Entrants

4.3.4 Threat of Substitute Products and Services

4.3.5 Competitive Rivalry within the Industry

5. Regenerative Medicine Market Dynamics

5.1 Drivers

5.2 Restraints

5.3 Opportunities

6. Global Regenerative Medicine Market, Segmented by Size

7. Global Regenerative Medicine Market, Segmented by Technology Type

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8. Global Regenerative Medicine Market, Segmented by Geography

8.1 North America

8.1.1 United States

8.1.2 Canada

8.1.3 Mexico

8.1.4 Others

8.2 South America

8.2.1 Brazil

8.2.2 Argentina

8.2.3 Others

8.3 Asia-Pacific

8.3.1 China

8.3.2 Japan

8.3.3 India

8.3.4 Others

8.4 Europe

8.4.1 United Kingdom

8.4.2 Germany

8.4.3 France

8.4.4 Others

8.5 Africa and Middle East

8.5.1 UAE

8.5.2 South Africa

8.5.3 Saudi Arabia

8.5.4 Others

9. Competitive Landscape

9.1 Introduction

9.2 Market Share Analysis

9.3 Developments of Key Players

10. Key Vendor Analysis (Overview, Products & Services, Strategies)

11. Future Outlook of the Market

12. Disclaimer

And Many More.

For Detail TOC Click Here

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$30+ Billion Cell Expansion Market by Product, Cell Type, Application, End-user and Region – Forecast to 2025 – ResearchAndMarkets.com – Business Wire

DUBLIN--(BUSINESS WIRE)--The "Cell Expansion Market by Product (Reagent, Media, Flow Cytometer, Centrifuge, Bioreactor), Cell Type (Human, Animal), Application (Regenerative Medicine & Stem Cell Research, Cancer & Cell-based Research), End-User, and Region - Global Forecast to 2025" report has been added to ResearchAndMarkets.com's offering.

The global cell expansion market is projected to reach USD 30.06 billion by 2025 from an estimated USD 14.91 billion in 2020, at a CAGR of 15.1%.

The report segments the cell expansion market based on region (Asia Pacific, Europe, North America, and RoW), product (consumables and instruments), cell type (human cells and animal cells), application (regenerative medicine and stem cell research, cancer and cell-based research and other applications), and end user (research institutes, biotechnology and biopharmaceutical companies, cell banks, and other end users). The report also provides a comprehensive review of market drivers, restraints, and opportunities in the cell expansion market.

Increasing incidence of chronic diseases and government investments for cell-based research are set to drive the cell expansion market

Growth in this market is largely driven by the increasing incidence of chronic diseases, government investments for cell-based research, growing focus on personalized medicine, increasing focus on R&D for cell-based therapies, and increasing GMP certifications for cell therapy production facilities. On the other hand, ethical concerns regarding research in cell biology are expected to limit market growth to a certain extent in the coming years.

By instruments type, the cell expansion supporting equipment accounted for the fasted growing product segment of the cell expansion market

The instruments segment includes cell expansion supporting equipment, bioreactors, and automated cell expansion systems. The cell expansion supporting equipment market includes flow cytometers, cell counters and hemocytometers, centrifuges, and other supporting equipment. They are used in cell culture processes for isolating, culturing, scaling-up, and extracting biological products. These instruments are essential in laboratories and institutes for conducting research and analyzing the cell structure and function for cell therapy research.

By cell type, the human cells segment accounted for the largest share of the cell expansion market

Based on cell type, the cell expansion market is segmented into human cells and animal cells. The human cells segment includes stem cells and differentiated cells. The stem cells segment is further classified into adult stem cells, ESCs, and iPSCs. The human cells segment accounted for the larger share of the cell expansion market majorly due to the increasing investments by public and private organizations for research on human cells, growing application areas of human stem cells, and the growing incidence of diseases such as cancer.

Asia Pacific: The fastest-growing region in the cell expansion market

The Asia Pacific market is projected to grow at the highest CAGR during the forecast period, mainly due to the increasing focus of players on emerging Asian markets, increasing incidence of chronic and infectious diseases, rising geriatric population, and government initiatives for infrastructural improvements of healthcare facilities are driving the growth of the cell expansion market in this region.

North America: the largest share of the cell expansion market

North America accounted for the largest share of the cell expansion market. The large share of this segment can primarily be attributed to the rising incidence of cancer, increasing government funding, rising research activates on stem cell therapies, growing awareness regarding advanced treatment methods, growing geriatric population, and the strong presence of industry players in the region.

Company Profiles

Established Companies

Start-up Companies

For more information about this report visit https://www.researchandmarkets.com/r/y35ufs

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$30+ Billion Cell Expansion Market by Product, Cell Type, Application, End-user and Region - Forecast to 2025 - ResearchAndMarkets.com - Business Wire