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Stem Cell Cartilage Regeneration Market Size, Share, Growth-Trends, Emerging-Technologies, Software-Platforms, 2020 Global Development,…

arcognizance.com has added latest research report on Global Stem Cell Cartilage Regeneration Market, this report helps to analyze top manufacturers, regions, revenue, price, and also covers Industry sales channel, distributors, traders, dealers, research findings, conclusion, appendix and data source.

HNY Research projects that the Stem Cell Cartilage Regeneration market size will grow from XXX in 2019 to XXX by 2025, at an estimated CAGR of XX. The base year considered for the study is 2019, and the market size is projected from 2020 to 2025.

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By Market Players: Anika Therapeutics, Zimmer Biomet, BioTissue Technologies, DePuy (Johnson & Johnson), Genzyme, CellGenix, EMD Serono, Sanofi Aventis, Smith & Nephew

By Application Hyaline Cartilage, Fibrocartilage, Other

By Type Cell Based Approaches, Non-cell Based Approaches

The prime objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing. Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts. The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

Brief about Stem Cell Cartilage Regeneration Market Report with TOC @ https://www.arcognizance.com/report/2020-2025-global-and-regional-stem-cell-cartilage-regeneration-industry-production-sales-and-consumption-status-and-prospects-professional-market-research-report

Points Covered in The Report: The points that are discussed within the report are the major market players that are involved in the market such as manufacturers, raw material suppliers, equipment suppliers, end users, traders, distributors and etc. The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. The historical data from 2014 to 2019 and forecast data from 2020 to 2025. The growth factors of the market is discussed in detail wherein the different end users of the market are explained in detail. Data and information by manufacturer, by region, by type, by application and etc, and custom research can be added according to specific requirements. The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.

Key Reasons to Purchase To gain insightful analyses of the market and have comprehensive understanding of the global market and its commercial landscape. Assess the production processes, major issues, and solutions to mitigate the development risk. To understand the most affecting driving and restraining forces in the market and its impact in the global market. Learn about the market strategies that are being adopted by leading respective organizations. To understand the future outlook and prospects for the market. Besides the standard structure reports, we also provide custom research according to specific requirements.

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Table of Content

Chapter One: Industry Overview

Chapter Two: Major Segmentation (Classification, Application and etc.) Analysis

Chapter Three: Production Market Analysis

Chapter Four: Sales Market Analysis

Chapter Five: Consumption Market Analysis

Chapter Six: Production, Sales and Consumption Market Comparison Analysis

Chapter Seven: Major Manufacturers Production and Sales Market Comparison Analysis

Chapter Eight: Competition Analysis by Players

Chapter Nine: Marketing Channel Analysis

Chapter Ten: New Project Investment Feasibility Analysis

Chapter Eleven: Manufacturing Cost Analysis

Chapter Twelve: Industrial Chain, Sourcing Strategy and Downstream Buyers

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List of Table and Figure

Figure Product Picture Table 2014-2019 Major Types Market Sales Volume And Market Share Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Table 2014-2019 Capacity, Production, Capacity Utilization Rate, Ex-Factory Price, Revenue, Cost, Gross And Gross Margin Figure 2014-2019 Capacity, Production And Growth Rate Figure 2014-2019 Capacity, Production And Capacity Utilization Rate continued

Note:

Due to the ongoing COVID-19 pandemic around the world, the figures in the report study represented in the study might differ along with production capacities and other mentioned aspects. Also, note that there is a possibility of a cooldown period after the pandemic that the data might differ as the world economy aims to catch on.

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Stem Cell Cartilage Regeneration Market Size, Share, Growth-Trends, Emerging-Technologies, Software-Platforms, 2020 Global Development,...

Flow Cytometry Market Report Extensive Analysis 2020 | Specified by Production, Technology, Competition, and Revenue Forecast till 2024 – 3rd Watch…

Agilent Technologies

Scope of the Report:

Flow cytometry is a laser or an impedance-based technology, which is used in cell counting, detecting biomarker, cell sorting, and protein engineering, by suspending the cell in a stream of fluid and then passing them through a detection apparatus. It is the ideal tool to identify, characterize, and isolate stem and progenitor cells, for research and potential clinical use.

The Report Covers:

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Key Market Trends:

Stem Cell Therapy is Expected to Hold the Largest Market Share, by Application

The stem cell therapy segment is believed to have the largest market size and is expected to witness a CAGR of 8.4% during the forecast period.

The key reasons for the large market share include the extensive use of flow cytometry for effective diagnosis and early detection of numerous diseases that have helped the market to gain immense shares. There has been a growing market penetration in stem cell research, adoption of recombinant DNA technology for antibody production, and the evolution of tandem flow cytometry technologies that are expected to offer growth opportunities for the players operating in the flow cytometry market during the forecast period.

Though flow cytometry has also found many applications in several stages of drug discovery, its routine widespread use for high throughput drug screening has been limited. This is unlike analogous technology, automated high content imaging (HCI), which, in terms of drug screening, is an established technology that is common in screening laboratories.

North America Dominates the Market and is Expected to Continue its Lead over the Forecast Period

North America holds a major share of the flow cytometry market and is projected to continue over the next few years. An increasing prevalence of diseases and the rising contribution from the US market are expected to help the market grow. In addition, there has also been a rise in the expansion of novel products that are anticipated to offer new growth opportunities in the coming years.

Key Questions Answered in This Report:

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Detailed TOC of Flow Cytometry Market 2019-2024:

1 INTRODUCTION 1.1 Study Deliverables 1.2 Study Assumptions 1.3 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS 4.1 Market Overview 4.2 Market Drivers 4.2.1 Use of Flow Cytometry in Stem Cell Research 4.2.2 Emergence and Commercial Applications of New Technologies in the Field of Flow Cytometry 4.2.3 Increasing Applications of Flow Cytometry in Clinical Research 4.3 Market Restraints 4.3.1 Lack of Awareness about the Potential Benefits of Flow Cytometry Techniques 4.3.2 Expensive Equipment 4.4 Industry Attractiveness Porters Five Forces Analysis 4.4.1 Threat of New Entrants 4.4.2 Bargaining Power of Buyers/Consumers 4.4.3 Bargaining Power of Suppliers 4.4.4 Threat of Substitute Products 4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION 5.1 Product Type 5.1.1 Instrument 5.1.2 Fluorophore 5.1.3 Kit and Reagent 5.1.4 Software 5.1.5 Other Product Types 5.2 Technology 5.2.1 Cell-based Flow Cytometry 5.2.2 Bead-based Flow Cytometry 5.3 Application 5.3.1 Oncology 5.3.2 Drug Discovery 5.3.3 Disease Diagnosis 5.3.4 Stem Cell Therapy 5.3.5 Organ Transplantation 5.3.6 Hematology 5.3.7 Other Applications 5.4 By End User 5.4.1 Hospitals and Clinics 5.4.2 Academia and Research Institutes 5.4.3 Pharmaceutical and Biotechnology Companies 5.4.4 Other End Users 5.5 Geography 5.5.1 North America 5.5.1.1 US 5.5.1.2 Canada 5.5.1.3 Mexico 5.5.2 Europe 5.5.2.1 Germany 5.5.2.2 UK 5.5.2.3 France 5.5.2.4 Italy 5.5.2.5 Spain 5.5.2.6 Rest of Europe 5.5.3 Asia-Pacific 5.5.3.1 China 5.5.3.2 Japan 5.5.3.3 India 5.5.3.4 Australia 5.5.3.5 South Korea 5.5.3.6 Rest of Asia-Pacific 5.5.4 Middle East & Africa 5.5.4.1 GCC 5.5.4.2 South Africa 5.5.4.3 Rest of Middle East & Africa 5.5.5 South America 5.5.5.1 Brazil 5.5.5.2 Argentina 5.5.5.3 Rest of South America

6 COMPETITIVE LANDSCAPE 6.1 Company Profiles 6.1.1 Becton, Dickinson and Company 6.1.2 Beckman Coulter 6.1.3 EMD Millipore (Merck KGaA) 6.1.4 Bio-Rad Laboratories 6.1.5 Luminex Corporation 6.1.6 Life Technologies 6.1.7 Miltenyi Biotech 6.1.8 Sysmex Partec GmbH 6.1.9 Agilent Technologies

7 MARKET OPPORTUNITIES AND FUTURE TRENDS

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Flow Cytometry Market Report Extensive Analysis 2020 | Specified by Production, Technology, Competition, and Revenue Forecast till 2024 - 3rd Watch...

Global Form and Surface Measuring Machine Market 2026 Size, Key Companies, Trends, Growth And Regional Forecasts Research – Cole of Duty

Form and Surface Measuring Machine Market

DataIntelo, 17-07-2020: The research report on the Form and Surface Measuring Machine Market is a deep analysis of the market. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. Experts have studied the historical data and compared it with the changing market situations. The report covers all the necessary information required by new entrants as well as the existing players to gain deeper insight.

Furthermore, the statistical survey in the report focuses on product specifications, costs, production capacities, marketing channels, and market players. Upstream raw materials, downstream demand analysis, and a list of end-user industries have been studied systematically, along with the suppliers in this market. The product flow and distribution channel have also been presented in this research report.

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The Major Manufacturers Covered in this Report: KLA-Tencor Mitutoyo ACCRETECH Mahr Carl Zeiss Taylor Hobson Keyence Zygo Jenoptik Bruker Nano Surfaces Kosaka Laboratory Chotest Alicona Polytec Wale Guangzhou Wilson

The Research Study Focuses on:

By Types: Contact Contour and Surface Measuring Machine Non-Contact Contour and Surface Measuring Machine

By Applications: Automotive Mechanical Products Electronic Products Others

By Regions:

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The Form and Surface Measuring Machine Market Report Consists of the Following Points:

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In conclusion, the Form and Surface Measuring Machine Market report is a reliable source for accessing the research data that is projected to exponentially accelerate your business. The report provides information such as economic scenarios, benefits, limits, trends, market growth rate, and figures. SWOT analysis is also incorporated in the report along with speculation attainability investigation and venture return investigation.

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Global Form and Surface Measuring Machine Market 2026 Size, Key Companies, Trends, Growth And Regional Forecasts Research - Cole of Duty

Biotechnology Reagents Market To Witness Massive Growth Worldwide | Global Players Abbott, Agilent Technologies Inc., Danaher, Bd, Bio-Rad…

Wide ranging Biotechnology Reagents Market report provides better ideas and solutions in terms of product trends, marketing strategy, future products, new geographical markets, future events, sales strategies, customer actions or behaviours. Statistical data mentioned in this market document is symbolized with the help of graphs which simplifies the understanding of facts and figures. With the precise and high-tech information, about Healthcare industry, businesses can know about the types of consumers, consumers demands and preferences, their perspectives about the product, their buying intentions, their response to particular product, and their varying tastes about the specific product already existing in the market through this Biotechnology Reagents Market report.

Biotechnology Reagents Market analysis report helps in growing sales with new thinking, new skills, and innovative programs and tools. With the study of competitor analysis, Healthcare industry can get knowhow of the strategies of key players in the market that includes but are not limited to new product launches, expansions, agreements, joint ventures, partnerships, and acquisitions. An all-inclusive data and information provided in the report can be utilized by Healthcare industry to be acquainted with the present and upcoming opportunities and clarify the future investment in the market. The Biotechnology Reagents Market report will act as a sure shot solution to the challenges and problems faced by Healthcare industry.

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Market Analysis: Global Biotechnology Reagents Market

Global biotechnology reagents market is expected to rise from its initial estimated value of USD 65.82 billion in 2018 to an estimated value of USD 118.53 billion by 2026, registering a CAGR of 7.63% in the forecast period of 2019-2026. This rise in market value can be attributed to the significant investments by private players in biotechnology.

Key Market Competitors:

Few of the major competitors currently working in thebiotechnology reagents marketareAbbott, Agilent Technologies Inc., Danaher, BD, Bio-Rad Laboratories Inc., General Electric, bioMrieux SA, LONZA, F. Hoffmann-La Roche Ltd., Thermo Fisher Scientific Inc., Hoefer, Inc., Meridian Bioscience, Inc., PerkinElmer Inc., Merck KGaA, Promega Corporation, Quality Biological, Siemens AG, Bio-Techne, TAKARA HOLDINGS INC., Sysmex Corporation, Tosoh Corporation, WATERS, W. R. Grace & Co.-Conn., Ortho Clinical Diagnostics, Olympus Corporation and Fitzgerald Industries International among others.

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Market Definition: Global Biotechnology Reagents Market

Biotechnology reagents are the substances or compounds used to detect or synthesize another substance in order to provide a test reading. These reagents are used in the field of research, genetics, molecular biology, diagnosis, immunology and bioscience. Biotechnology reagents comprises of technologies such as cell culture, spectrometry, IVD, PCR, chromatography, expression and transfection, flow cytometry, and electrophoresis, and find their application in areas such as immune phenotyping, fluorescent microscopy, DNA analysis and cell cycle analysis.

According to the Innovative Research, in U.S., around 65% of biotech companies are involved in drug developed with an intention to serve them for medical purposes and pharmaceuticals. Growing number of biotechnology firms in various countries is expected to act as a driver for the market growth.

Biotechnology Reagents Market Drivers :

Biotechnology Reagents Market Restraints :

Segmentation: Global Biotechnology Reagents Market

Biotechnology Reagents Market : By Technology

Biotechnology Reagents Market : By Applications

Biotechnology Reagents Market : By Geography

Key Developments in the Biotechnology Reagents Market :

Competitive Analysis:

Global biotechnology reagents market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of biotechnology reagents market for global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

Research Methodology: Global Biotechnology Reagents Market

Data collection and base year analysis is done using data collection modules with large sample sizes. The market data is analysed and forecasted using market statistical and coherent models. Also market share analysis and key trend analysis are the major success factors in the market report. To know more pleaseRequest an Analyst Callor can drop down your inquiry.

The key research methodology used byDBMR Researchteam is data triangulation which involves data mining, analysis of the impact of data variables on the market, and primary (industry expert) validation. Apart from this, other data models include Vendor Positioning Grid, Market Time Line Analysis, Market Overview and Guide, Company Positioning Grid, Company Market Share Analysis, Standards of Measurement, Top to Bottom Analysis and Vendor Share Analysis. To know more about the research methodology, drop in an inquiry to speak to our industry experts.

Primary Respondents :

Demand Side: Doctors, Surgeons, Medical Consultants, Nurses, Hospital Buyers, Group Purchasing Organizations, Associations, Insurers, Medical Payers, Healthcare Authorities, Universities, Technological Writers, Scientists, Promoters, and Investors among others.

Supply Side: Product Managers, Marketing Managers, C-Level Executives, Distributors, Market Intelligence, and Regulatory Affairs Managers among others.

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Biotechnology Reagents Market To Witness Massive Growth Worldwide | Global Players Abbott, Agilent Technologies Inc., Danaher, Bd, Bio-Rad...

Self Care Revolution, Mayor Asks Advisory Board Member to Resign, Nebraska Files Lawsuit Against Stem Cell Clinics and more Top Local News for Friday,…

7/17/20 Day 26 ofPhase IIINationwide case trends

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New Legal Options Coming for Protestors Arrested for Breaking Curfew

What are we saying about Omaha if we begin to criminalize the act of expressing a constitutional right? says activist, JaKeen Fox.

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Good morning,

Today we have stories self care being a revolutionary act forindividuals resisting oppression, Mayor Jean Stothert asking a member of the citys LGBTQ+AdvisoryBoard to resign and Nebraskasattorney general filing a lawsuit against Omaha stem cell therapy clinics.

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Self Care Revolution, Mayor Asks Advisory Board Member to Resign, Nebraska Files Lawsuit Against Stem Cell Clinics and more Top Local News for Friday,...

COVID-19 Impact on Cell Therapy Industry 2020: Global Market Size, Share, Emerging Trends, Business Growth Applications, SWOT Analysis by Top Key…

TheGlobal Cell Therapy Marketwas estimated to be valued at USD XX million in 2018 and is projected to reach USD XX million by 2026, at a CAGR of XX% during 2019 to 2026. Growing aging patient population, the rise in cell therapy transplantations globally, and rising disease awareness drive the growth of the market.

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What you can expect from our report: Total Addressable Market [ Present Market Size forecasted to 2026 with CAGR ] Regional level split [North America, Europe, Asia Pacific, South America, Middle East & Africa] Country wise Market Size Split [Important countries with major market share] Market Size Breakdown by Product/ Service Types [ ] Market Size by Application/Industry verticals/ End Users [ ] Market Share and Revenue/Sales of 10-15 Leading Players in the Market Production Capacity of Leading Players whenever applicable Market Trends Emerging Technologies/products/start-ups, PESTEL Analysis, SWOT Analysis, Porters Five Forces, etc. Pricing Trend Analysis Average Pricing across regions Brandwise Ranking of Major Market Players globally

Cell therapyinvolves the administration of somatic cell preparations for the treatment of diseases or traumatic damages. The objective of this study is to provide long term treatment through a single injection of therapeutic cells.

However, stringent regulatory policies may restrain growth of the market in the forecast period.

The global Cell Therapy Market is primarily segmented based on different type, technique, cell source, technology, end users and region.

On the basis of type, the market is split into: * Allogenic Therapies * Autologous Therapies

On the basis of technique, the market is split into: * Stem Cell Therapy * Cell Vaccine * Adoptive Cell Transfer (ACT) * Fibroblast Cell Therapy * Chondrocyte Cell Therapy * Other Technique

On the basis of cell source, the market is split into: * Bone Marrow * Adipose Tissue * Umbilical Cord Blood-Derived Cells

On the basis of technology, the market is split into: * Viral Vector Technology * Cell Immortalization Technology * Genome Editing Technology

On the basis of end user, the market is split into: * Hospitals & Clinics * Regenerative Medicine Centers * Other End Users

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Moreover, the market is classified based on regions and countries as follows: * North America- U.S., Canada * Europe- U.K., France, Germany, Italy and Rest of Europe * Asia-Pacific- China, Japan, India and Rest of Asia Pacific * South America- Brazil, Mexico and Rest of South America * Middle East & Africa- South Africa, Saudi Arabia and Rest of Middle East & Africa

Key Market Players: The key players profiled in the market include: * Kolon TissueGene, Inc. * JCR Pharmaceuticals Co. Ltd. * Osiris Therapeutics, Inc. * Stemedica Cell Technologies, Inc. * Fibrocell Science, Inc. * Vericel Corporation * Pharmicell Co., Ltd * Anterogen.CO.,LTD. * Baxter Healthcare Corporation. * Arteriocyte Medical Systems

These enterprises are focusing on growth strategies, such as new product launches, expansions, acquisitions, and agreements & partnerships to expand their operations across the globe.

Key Benefits of the Report: * Global, regional, country, type, technique, cell source, technology, end users market size and their forecast from 2018-2026 * Identification and detailed analysis on key market dynamics, such as, drivers, restraints, opportunities, and challenges influencing growth of the market * Detailed analysis on industry outlook with market specific PESTLE, and supply chain to better understand the market and build expansion strategies * Identification of key market players and comprehensively analyze their market share and core competencies, detailed financial positions, key product, and unique selling points * Analysis on key players strategic initiatives and competitive developments, such as joint ventures, mergers, and new product launches in the market * Expert interviews and their insights on market shift, current and future outlook, and factors impacting vendors short term and long term strategies * Detailed insights on emerging regions, type, technique, cell source, technology and end users with qualitative and quantitative information and facts

Target Audience: * Cell Therapy Manufactures * Traders, Importers, and Exporters * Raw Material Suppliers and Distributors * Research and Consulting Firms * Government and Research Organizations * Associations and Industry Bodies

Research Methodology: The market is derived through extensive use of secondary, primary, in-house research follows by expert validation and third party perspective, such as, analyst reports of investment banks. The secondary research is the primary base of our study wherein we conducted extensive data mining, referring to verified data products, such as, white papers, government and regulatory published articles, technical journals, trade magazines, and paid data products.

For forecasting, regional demand & supply factors, recent investments, market dynamics including technical growth scenario, consumer behavior, and end use trends and dynamics, and production capacity were taken into consideration. Different weightages have been assigned to these parameters and quantified their market impacts using the weighted average analysis to derive the market growth rate.

The market estimates and forecasts have been verified through exhaustive primary research with the Key Industry Participants (KIPs), which typically include: * Manufacturers * Suppliers * Distributors * Government Body & Associations * Research Institutes

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Table of Content 1. Introduction 2. Research Methodology 3. Executive Summary 4. Global Cell Therapy Market Overview 4.1. Market Segmentation & Scope 4.2. Market Trends 4.2.1. Drivers 4.2.2. Restraints 4.2.3. Opportunities 4.2.4. Supply Chain Analysis 4.3. Global Cell Therapy Market Porters Five Forces Analysis 4.4. Global Cell Therapy Market PESTEL Analysis 5. Global Cell Therapy Market, by Type 5.1. Global Cell Therapy Market, Size and Forecast, 2015-2026 5.2. Global Cell Therapy Market, by Allogenic Therapies, 2015-2026 5.2.1. Key driving factors, trends and opportunities 5.2.2. Market size and forecast, 2015-2026 5.3. Global Cell Therapy Market, by Autologous Therapies, 2015-2026 5.3.1. Key driving factors, trends and opportunities 5.3.2. Market size and forecast, 2015-2026 6. Global Cell Therapy Market, by Technique 6.1. Global Cell Therapy Market, Size and Forecast, 2015-2026 6.2. Global Cell Therapy Market, by Stem Cell Therapy, 2015-2026 6.2.1. Key driving factors, trends and opportunities 6.2.2. Market size and forecast, 2015-2026 6.3. Global Cell Therapy Market, by Cell Vaccine, 2015-2026 6.3.1. Key driving factors, trends and opportunities 6.3.2. Market size and forecast, 2015-2026

..Continued

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COVID-19 Impact on Cell Therapy Industry 2020: Global Market Size, Share, Emerging Trends, Business Growth Applications, SWOT Analysis by Top Key...

Attorney General Peterson Files Lawsuit Against Stem Cell …

Attorney General Expresses Concern About Stem Cell Clinics Advertisements and Cure-All Claims

LINCOLN Attorney General Doug Peterson filed a Complaint today in the District Court of Douglas County against Omaha Stem Cells, LLC, Regenerative Medicine and Anti-Aging Institutes of Omaha, LLC, Stem Cell Centers, LLC and Travis and Emily Autor (collectively the Defendants). The case relates to the Defendants marketing and sale of stem cell therapy to consumers, often following aggressive marketing through local media and in-person seminars throughout Nebraska and Iowa. The Defendants operated a clinic until recently in Omaha. The Attorney General conducted his investigation in cooperation with Iowa Attorney General Tom Miller, who filed a similar lawsuit today in Iowa.

The Attorney General alleges the Defendants made over $2 million by making deceptive and misleading statements to consumers regarding the ability of their stem cell therapy to treat specific diseases and health conditions, including joint pain, back pain, osteoarthritis, neuropathy, and COPD. The lawsuit also alleges the Defendants misrepresented that stem cell therapy is safe and that larger doses are more effective, without possessing the necessary evidence to make these types of claims.

In his lawsuit, the Attorney General acknowledges prior statements by the FDA that stem cells have the potential to repair, restore, replace and regenerate cells, and in the future could possibly be used to treat many medical conditions and diseases. However, stem cell use for most medical conditions remains unproven and, therefore, unapproved by the FDA. In September 2019, the FDA warned consumers that the unapproved use of stem cell treatments can be particularly unsafe, and may lead to adverse reactions, such as the failure of cells to function as expected and tumor growth.

Unfortunately, this warning may have come too late for some consumers in Nebraska. In December 2019, the FDA issued a more specific Public Safety Notification regarding multiple reports of serious adverse events experienced by patients in Nebraska who were treated with unapproved products marketed as containing exosomes. According to the Attorney Generals lawsuit, the Defendants were advertising and administering unapproved exosome products to consumers.

Attorney General Peterson stated, Consumers are entitled to accurate and truthful information about any product or service, but especially those products that affect their health and wellbeing. With todays filing, we remind all healthcare providers and other businesses that they will be held accountable for the representations they make to consumers.

Consumers in Nebraska, and across the country, need to heed these warnings when it comes to stem cell products. According to the Attorney General, Travis and Emily Autor operate a network of companies across the country that advertise and sell stem cell therapy directly to consumers. In addition to their clinic in Omaha, the Autors have been affiliated with clinics located in Arizona, Florida, Idaho, Montana, Vermont, Virginia, and Washington.

According to the FDA, those considering whether to undergo treatment with stem cell products, including exosomes, should:

Ask if the FDA has reviewed the treatment before getting treatmenteven if the stem cells are their own. Ask their health care provider to confirm this information.

Make sure they understand the entire process and known risks before consenting to participate in a clinical trial. To participate in a clinical trial that requires an Investigational New Drug Application (IND), the consumer must sign a consent form that explains the experimental procedure. The consent form also identifies the Institutional Review Board (IRB) that assures the protection of the rights and welfare of human subjects.

Be cautious when considering treatment in another country. Know that the FDA does not have oversight of treatments done in other countries.

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Attorney General Peterson Files Lawsuit Against Stem Cell ...

Upper Cervical Ligament Stem Cell Injection: Restores Hope …

The car accident was at low speed and you hit your head on the headrest. You are left with constant headaches, dizziness, and mental fog that is all new. Regrettably, your doctors are all baffled and think it may be psychological or post-traumatic stress disorder. What is craniocervical instability? What causes craniocervical instability? How is craniocervical instability treated? Are there non-surgical treatment options? Whats an upper cervical ligament stem cell injection? Lets dig in.

First, some basic anatomy and terminology are required. Your head is also referred to as the cranium. The neck is also known as the cervical spine. The craniocervical junction is simply where your head meets the neck. The head is connected to the cervical spine by important ligaments. These ligaments provide important stability that keep your head, brain, and spinal cord snugly attached to your neck. Damage to the ligaments can cause excessive movement between the head and neck which is called craniocervical instability (1).

Trauma, degeneration, and genetic disorders that affect collagen and ligament strength all can cause craniocervical instability (2). The most common symptoms associated with CCI include

Severe Headache: Unlike the garden variety headache this is a headache that is constant, involves most of the head, and stops you in your tracks.

Dizziness/Balance Dysfunction: Simple tasks like walking down the hall or across the street are impossible at times due to the dizziness (3).

Brain Fog: Mental fog and delayed mental processing that prevent completion of simple tasks such as domestic chores and self-care.

Other symptoms may include increased heart rate, changes in GI function, visual problems, irritability and mood swings

The severity of the craniocervical instability dictates treatment. Conservative care is the first-line treatment when appropriate and includes chiropractic care and cervical stabilization. When these fail many patients are referred for surgery. The surgery is significant and involves a fusion of the back of the head (occiput) and cervical spine. It involves screws that are placed in the skull and cervical spine and rods that connect the two. The goal of surgery is to stabilize the head/neck junction. The surgery is extensive, fraught with risks, and forever changes a patients ability to move the neck and head. The x-ray in the featured image is an occipital cervical fusion used to treat CCI.

Surgical fusion was the standard treatment of CCI until 2015 when the Centeno-Schultz Clinic developed the first nonsurgical treatment. The procedure involves the placement of a patients own bone marrow-derived stem cells into the damaged ligaments that stabilize the craniocervical junction. The stem cells are injected through a needle that is placed in the back of the mouth and carefully advanced into the damaged ligaments using x-ray guidance. The procedure is called the PICL which stands for the Percutaneous Injection of Cervical Ligaments. It is an extremely demanding procedure given the spinal cord and other important structures are only millimeters from the injected ligaments. Orthopedic surgeons and neurosurgeons are not able to perform this procedure. In fact, the Centeno-Schultz Clinic is the only place in the world that performs the PICL procedure. The Craniocervical Joint (CCJ) Instability Institute provides an in-depth opportunity to learn more about CCI and regenerative options. To learn more about the PICL procedure please watch the video below.

Treatment results to date have been transformative and in many cases life-changing for many patients. Today I had the pleasure of seeing one of my patients who underwent the PICL procedure. Meet Mike.

Craniocervical instability involves excessive movement between the head and neck. Ligaments are thick bands of connective tissue that connect one bone to another. Cervical ligaments provide stability for the head-neck junction. Damage, wear and tear, and genetic disorders can compromise these ligaments leading to instability. Vital structures such as the brain, brainstem, spinal cord, and nerves are irritated during this excessive movement. Traditional treatment for symptomatic cases of CCI that failed conservative care involves the fusion of the head to the spine. The PICL is an effective, non-surgical treatment option for patients with craniocervical instability. This unique upper cervical ligament stem cell injection procedure allows patients to use their own bone marrow-derived stem cells to accelerate healing of the damaged or weakened ligaments and avoid the complications of surgery.

1.Offiah CE, Day E. The craniocervical junction: embryology, anatomy, biomechanics and imaging in blunt trauma.Insights Imaging. 2017;8(1):2947. doi:10.1007/s13244-016-0530-5

2.Klein GN, Mannion AF, Panjabi MM, Dvorak J. Trapped in the neutral zone: another symptom of whiplash-associated disorder?.Eur Spine J. 2001;10(2):141148. doi:10.1007/s005860100248

3 Thompson-Harvey A, Hain TC. Symptoms in cervical vertigo. Laryngoscope Investig Otolaryngol. 2018;4(1):109115. Published 2018 Nov 28. doi:10.1002/lio2.227.

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Upper Cervical Ligament Stem Cell Injection: Restores Hope ...

Stem Cell Therapy for Neuropathy | Mayo Clinic Connect

Hi @jlsoerens One of the focus areas on Mayo Clinic's Regenerative Medicine Program is in neuroregeneration. You can read more here: https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/focus-areas/neuroregeneration Scroll down the page and you can read clinical research being done specifically for peripheral nerve regeneration and repair.

Unfortunately, because of the complexity of the brain and spinal cord, little spontaneous regeneration, repair or healing occurs. Therefore, brain damage, paralysis from spinal cord injury and peripheral nerve damage are often permanent and incapacitating.

To learn more, you may wish to contact Mayo Clinics Regenerative Medicine free Consult Service. If you call them, you will talk to a live person who will provide more information, research, and advice on seeking stem cell therapy from reputable providers, even if that provider is not Mayo Clinic. Their primary goal is to educate and help you find effective treatment. Furthermore, you can add your name to a database to be notified when additional studies and information become available. Heres more information about the stem cell Consult Service http://www.mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/clinical-services/regenerative-medicine-consult-service. Or simply call 1-844-276-2003 to speak with one of our experts.

I also feel it important to add it is so important to do your homework and due diligence when researching new treatment options. Stem cells offer a lot of hope. But where these is hope, there is hype and charlatans. FDA acts to remove unproven, potentially harmful treatment used in stem cell centers targeting vulnerable patients https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm573427.htm

You can read more about stem cells on the FDAs website here: https://www.fda.gov/AboutFDA/Transparency/Basics/ucm194655.htm

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Stem Cell Therapy for Neuropathy | Mayo Clinic Connect

Comparison of Early and Late Transplant-Associated Thrombotic Microangiopathy – Hematology Advisor

Transplant-associated thrombotic microangiopathy (TA-TMA) is generally regarded as an early complication of hematopoietic stem-cell transplantation (HSCT); however, late TA-TMA appears to be nearly as common as early TA-TMA and both have similarly poor outcomes, according to findings published in the American Journal of Hematology.

In this retrospective study, the investigators aimed to characterize the risk factors and outcomes associated with early and late TA-TMA among patients receiving allogeneic HSCT. The researchers reviewed electronic medical records of adult patients who received allogeneic HSCT at the Mayo Clinic in Rochester, Minnesota, from January 2000 to June 2019. Patients were diagnosed with either early (before or on day 100 post-HSCT) or late (after day 100 post-HSCT) TA-TMA based on laboratory criteria.

Of 1451 HSCT recipients, 84 (5.8%) were diagnosed with TA-TMA at a median of 80 (range, 3-2595) days post-HCST: 45 patients (3.1%) were diagnosed with early TA-TMA at a median of 28 (range, 3-91) days and 39 patients (2.7%) were diagnosed with late TA-TMA at a median of 303 (range, 122-2595) days.

Of evaluated risk factors, patients with early TA-TMA were more likely to have calcineurin-inhibitor toxicity (66.7% vs 30.8%; P <0.001), acute graph-vs-host disease (GVHD; 66.7% vs 28.2%; P <.001), and prior HSCT (28.9% vs 5.1%; P =.005) compared with patients with late TA-TMA. Patients with late TA-TMA were more likely to have chronic GVHD during TMA than those with early TA-TMA (84.6% vs 0.0%; P <.001).

The median follow up was 6 months (range, 0-132). The overall mortality rate was 34.5% at 3 months and 66.7% at the end of follow up. The estimated median overall survival (OS) was 6 months. After 1 year and 3 years, no differences were observed in survival of patients with early and late TA-TMA (1-year, 36.4% vs 48.9%; 3-year, 33.9% vs 32.9%, respectively). The estimated median OS was not reached in patients who had improvement of TA-TMA, whereas in patients with no improvement, it was 2 months (P <.001).

In a multivariate analysis, older age (for every 10 years, hazard ratio [HR], 1.40; 95% CI, 1.00-1.94; P =.049) and bacterial infection (HR, 2.42; 95% CI, 0.98-6.00; P =.056) were positively associated with mortality in the early TA-TMA group. Conversely, switching from calcineurin-inhibitor to mycophenolate mofetil treatment (HR, 0.40; 95% CI, 0.16-0.99; P =.047) and improvement of TMA (HR, 0.08; 95% CI, 0.03-0.25; P <.001) were negatively associated with mortality in the early TMA group. Only 1 independent predictor, improvement of TA-TMA, was associated with a lower risk of death in the late TMA group (HR, 0.05; 95% CI, 0.02-0.19; P <.001).

Limitations of the study included its retrospective design and variable patient management; additionally, some patients may have been undiagnosed or diagnosed later than the onset of TA-TMA.

In conclusion, the characteristics and etiologies of early and late TMA may be different, but outcomes are similarly unfavorable. Future studies are needed to shed light on methods for a timely diagnosis, better definition of triggers of TMA, and to bring more targeted treatment options, concluded the authors.

Disclosures: Some authors have declared affiliations with the pharmaceutical industry. Please refer to the original study for a full list of disclosures.

Heybeli C, Sridharan M, Alkhateeb HB, et al. Characteristics of late transplantassociated thrombotic microangiopahy (TATMA) in patients who underwent allogeneic hematopoietic stem cell transplantation [published July 2, 2020]. Am J Hematol. doi: 10.1002/ajh.25922

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Comparison of Early and Late Transplant-Associated Thrombotic Microangiopathy - Hematology Advisor