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CAR T-Cell Therapy Offers Potential Solution for Relapse in MCL, But With Toxicity Risk – Targeted Oncology

By Stem Cell Medical Center

Mantle cell lymphoma (MCL) accounts for 5% to 10% of all non-Hodgkin lymphomas (NHLs) and is commonly diagnosed when a patients disease is in an advanced stage with extranodal involvement, commonly including gastrointestinal mucosa and central nervous system involvement with blastoid variant. Disease relapse among patients with MCL is known to occur after prolonged remission, which leaves an unanswered question among oncologists in the field of how to approach treatment of relapsed MCL.1

In a presentation during the 2020 Debates and Didactics in Hematology and Oncology conference, Amelia A. Langston, MD, professor and executive vice chair, Department of Hematology and Medical Oncology; director, Bone Marrow and Stem Cell Transplant Program; and medical director, Winship Cancer Network, at Winship Cancer Institute of Emory University, explained the issues with treating patients with relapsed MCL and how the integration of chimeric antigen receptor (CAR) T-cell therapy can be a solution to the problem.

Langston noted that MCL has multiple morphologic variants, including classical disease, aggressive or blastoid disease, and indolent disease. Although it is common for oncologists to treat patients with indolent tumors right after diagnosis, Langston highlighted that a small proportion of those patients do not require immediate treatment.

One method for understanding when to start treatment and to predict how patients with MCL will respond to treatment, is utilizing the MIPIc (Mantle Cell Lymphoma International Prognostic Index) prognostic score. Another method, Langston explained, is through gene expression profiles, karyotype, and mutation analysis, which can identify p53 mutations, NOTCH-1 mutations, complex karyotype, and overall poor prognosis.

The primary treatment for MCL is aggressive induction followed by autologous stem cell transplantation (ASCT), which has been shown to prolong survival in patients with MCL who are fit for aggressive treatment.

Research by Martin Dreyling, MD, PhD, et al presented in 2005 demonstrated the feasibility of early consolidation with myeloablative radiochemotherapy followed by ASCT. In the study, 62 patients underwent ASCT, and 122 patients received interferon (IFN) alpha. With ASCT, the median progression-free survival (PFS) was 39 months with ASCT versus 17 months with IFN-alpha (P = .0108). The 3-year overall survival (OS) rate with ASCT was 83% versus 77% with IFN-alpha (P = .18).2

Data presented at the American Society of Hematology Annual Meeting in 2009 showed a median OS of 90 months with ASCT compared with 54 months with IFN (P = .034).3

Once patients with MCL relapse, the treatment landscape includes FDA-approved targeted therapies, chemotherapy/immunotherapy combinations, and allogeneic hematopoietic stem cell transplant. The targeted therapies include Brutons tyrosine kinase (BTK) inhibitors, proteasome inhibitors, immunomodulatory drugs, mTOR inhibitors, venetoclax (Venclexta), as well as combination regimens.

The BTK inhibitor ibrutinib (Imbruvica) at a 560-mg daily dose level has led to an objective response rate (ORR) of 66% with a complete response (CR) rate of 20%, according to a pooled analysis of 3 open-label clinical trials, which were the PCYC1104 (NCT01236391), SPARK (NCT01599949), and RAY (NCT01646021) studies. The analysis included 370 patients with MCL who had a median of 2 prior lines of therapy before receiving ibrutinib. This analysis also showed that more than 1 line of prior therapy, p53 mutations, and blastoid histology were all predictors of poor response to ibrutinib.4,5

Acalabrutinib (Calquence), another BTK inhibitor, at a dose of 100 mg twice daily demonstrated efficacy in a single-arm multicenter, phase 2 clinical trial (ACE-LY-004, NCT02213926). The ACE-LY-004 study included 124 patients with a median 2 prior lines of therapy. The ORR achieved with acalabrutinib was 81% (95% CI, 73%-87%) per investigator assessment. The CR rate was 40% (95% CI, 31%-49%).6

In terms of survival, the 12-month PFS rate observed with acalabrutinib was 67% (range, 58%-75%) and the 12-months OS rate was 87% (range, 79%-92%).

The adverse events observed in ACE-LY-004 were considered tolerable and only led to treatment discontinuation in 6% of the study population.

Investigators led by Michael Wang, MD, of The University of Texas MD Anderson Cancer Center, concluded from this study that acalabrutinib holds an important place in the treatment landscape of MCL and induces a high rate of durable responses with tolerable safety.

For combination therapies in the MCL paradigm, ibrutinib plus venetoclax was investigated in a single-arm, multicenter, phase 2 study (AIM, NCT02471391), which enrolled 24 patients with MCL, 23 of whom had relapsed or refractory disease and 1 patient with a p53 mutation who was ineligible for chemotherapy. The median number of prior lines of therapy for this study population was 2, and 46% of patients had a p53 mutation and/or deletion. Ibrutinib was administered at 560 mg per day for 4 weeks and then venetoclax was added with a gradual dose escalation up to 400 mg per day.7

The combination of ibrutinib and venetoclax achieved a CR rate of 42% at 16 weeks, which surpassed the historical result of ibrutinib monotherapy (9%; P < .001). In addition, the CR rate among patients who were negative for minimal residual disease was 38%, and for patients with a p53 mutation, the CR rate was 50%. Ibrutinib plus venetoclax also achieved a PFS rate of 78% at 15 months.

The safety analysis did reveal 2 cases of tumor lysis syndrome in patients, however, but overall, the combination was well tolerated.

CAR T-cell therapy has already been integrated into the treatment landscape of many hematologic malignancies and is now being considered as a treatment for different solid tumors. CAR T-cell therapy is also a valid option for treatment of R/R MCL, and one agent, KTE-X19 has been granted Priority Review by the FDA for this indication based on results from the phase 2 ZUMA-2 trial.1

The multicenter study enrolled 74 patients and 68 of them received the CAR T-cell product. Among the MCL subjects, the subgroups included patients who relapsed after ASCT, relapsed after their most recent previous therapy, were refractory to BTK inhibition, relapsed during or after BTK inhibition, and could not receive BTK inhibition.8

In terms of efficacy, 85% of patients achieved an objective response, which included CRs in 59% of patients. In the various subgroups of patients with MCL included in the study, high rates of objective response were also observed. There were also 2 patients with stable disease and 2 with progressive disease.

Neither the median PFS nor OS were reached at the time of data cutoff, but the PFS rate at 1 year was estimated to be 61% in the study, and the OS rate was estimated to be 83% at 1 year.

The CAR T-cell agent led to grade 3 or higher AEs, the majority of which were cytopenias (94%); additionally, 32% were infections, 31% were neurologic events, 15% of patients had cytokine release syndrome, and 32% had hypogammaglobulinemia. The treatment-related mortality rate in this study was 3%, which was due to infections.

These data led to the conclusion that although KTE-X19 can induce durable remissions in patients with MCL, it causes serious toxicities that are common for CAR T-cell therapy. Thus, Langston noted in her presentation that CAR T-cell therapy for relapsed disease should only be considered for select patients.

Overall, BTK inhibition will likely remain a standard of care for R/R MCL, Langston stated, but CAR T-cell therapy should be carefully integrated into the landscape, once the first agent is granted FDA approval and depending on the indications of that approval. Finally, healthier patients with R/R MCL can continue to be considered for ASCT, which, she noted, has curative ability for heavily pretreated patients.1

References:

1. Langston AA. Integrating CAR t cell therapy into the management of relapsed mantle cell lymphoma. Presented at: 2020 Debates and Didactics in Hematology and Oncology; July 16-18, 2020; Sea Island, GA.

2. Dreyling M, Lenz G, Hoster E, et al. Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network. Blood. 2005;105(7):2677-2684. doi:10.1182/blood-2004-10-3883

3. Hoster E, Metzner B, Forstpointner R, et al. Autologous Stem Cell Transplantation and Addition of Rituximab Independently Prolong Response Duration in Advanced Stage Mantle Cell Lymphoma. Blood. 2009;114(22):880. doi:10.1182/blood.V114.22.880.880

4. Rule S, Dreyling M, Goy A, et al. Outcomes in 370 patients with mantle cell lymphoma treated with ibrutinib: a pooled analysis from three open-label studies. Br J Haematol. 2019;179(3):430-438. doi:10.1111/bjh.14870

5. Rule S, Dreyling M, Goy A, et al. Ibrutinib for the treatment of relapsed/refractory mantle cell lymphoma: extended 3.5-year follow up from a pooled analysis. Haematologica. 2019;104(5):e211-e214. doi:10.3324/haematol.2018.205229

6. Wang M, Rule S, Zinzani PL, et al. Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial. Lancet. 2017;391(10121):659-667. doi:10.1016/S0140-6736(17)33108-2

7. Tam CS, Andeson MA, Pott C, et al. Ibrutinib plus venetoclax for the treatment of mantle-cell lymphoma. N Engl J Med. 2018;378(13):1211-1223. doi:10.1056/NEJMoa1715519

8. Wang M, Munoz J, Goy A, et al. KTE-X19 CAR t-cell therapy in relapsed or refractory mantle-cell lymphoma. N Engl J Med. 2020;382(14):1331-1342. doi:10.1056/NEJMoa1914347

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CAR T-Cell Therapy Offers Potential Solution for Relapse in MCL, But With Toxicity Risk - Targeted Oncology

2 immunotherapies merged into single, more effective treatment – Washington University School of Medicine in St. Louis

By Stem Cell Clinic

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Mouse study suggests strategy may work against variety of cancers

Researchers at Washington University School of Medicine in St. Louis have combined two types of immunotherapy into a single treatment that may be more effective and possibly safer than current immunotherapies for blood cancers. Shown is a type of immune cell called a memory-like natural killer cell (right) attacking a leukemia cell (left). In the new study, the researchers modified the natural killer cells to help them find the leukemia cells more effectively.

Some of the most promising advances in cancer treatment have centered on immunotherapies that rev up a patients immune system to attack cancer. But immunotherapies dont work in all patients, and researchers have been searching for ways to increase their effectiveness.

Now, researchers at Washington University School of Medicine in St. Louis have combined two immunotherapy strategies into a single therapy and found, in studies in human cells and in mice, that the two together are more effective than either alone in treating certain blood cancers, such as leukemia. Evidence also suggests that the new approach could be safer than one of the most recent cellular immunotherapies to be approved by the FDA, called CAR-T cell therapy, in which the immune systems T cells are engineered to target tumor cells. Cell-based immunotherapies are most commonly used against blood cancers but can be harnessed against some solid tumors as well, such as prostate and lung tumors and melanoma.

The study appears online in the journal Blood.

In the new research, the scientists have harnessed the technology used to engineer CAR-T cells and, instead of modifying specialized immune cells called T cells, they have used similar technology to alter different immune cells called natural killer (NK) cells. The resulting immunotherapy combines the benefits of both strategies and may reduce the side effects that are sometimes seen in CAR-T cell therapy. In some patients, for example, CAR-T cell therapy causes a cytokine storm, a life-threatening overreaction of the immune system.

Immunotherapies show great promise for cancer therapy, but we need to make them more effective and more safe for more patients, said co-senior author Todd A. Fehniger, MD, PhD, a professor of medicine. This combined approach builds on the treatment strategy that we developed for leukemia patients using natural killer cells. We can supercharge natural killer cells to enhance their ability to attack cancer cells. And at the same time, we can use the genetic engineering approaches of CAR cell therapy to direct the natural killer cells to a tumor target that would normally be overlooked by NK cells. It fundamentally changes the types of cancer that NK cells could be used to treat, both additional blood cancers and potentially solid tumors as well.

In past work, Fehniger and his colleagues showed that they could collect a patients own NK cells, expose the cells to a specific recipe of chemical signals that prime the cells to attack tumors, and then return the primed cells to patients for therapy. This chemical exposure is a sort of basic training for the cells, according to the investigators, preparing the NK cells to fight the cancer. When the cells are then returned to the body, they remember their training, so to speak, and are more effective at targeting the tumor cells. Because their training has given the NK cells a memory of what to do when they encounter tumor cells, the researchers dubbed them memory-like NK cells.

In small clinical trials conducted at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, such cells were effective in putting some patients with leukemia into a lasting remission, but they didnt work for everyone. Some tumor cells still evaded the memory-like NK cells, despite the cells basic training. To help the cells find the tumor cells, so their basic training can kick in and kill the correct target, the researchers modified the memory-like NK cells with the same CAR (chimeric antigen receptor) molecule that is typically used to target T cells to tumor cells. The CAR molecule is flexible and can be modified to direct the cells to different tumor types, depending on the proteins on the surfaces of the cancer cells.

The resulting hybrid cells were more effective in treating mice with leukemia than memory-like NK cells alone, leading to longer survival for mice treated with CAR memory-like NK cells. The researchers also found the therapy to be effective despite the fact that the mice were given relatively low doses of the cells.

One aspect of this study I find most exciting is how nicely these hybrid NK cells expand in the mice to respond to their tumors, said co-senior author Melissa Berrien-Elliott, PhD, an instructor in medicine. We can provide a tiny dose and see an incredible amount of tumor control. To me, this highlights the potency of these cells, as well as their potential to expand once in the body, which is critical for translating these findings to the clinic.

Fehniger also pointed out that an advantage of NK cells in general and for biological reasons that the scientists are still working to understand NK cells dont trigger a dangerous immune response or the long-term side effects that T-cell therapy can cause in attacking the patients healthy tissues, a condition called graft-versus-host disease.

In all of the clinical trials exploring any type of NK cells, we dont see the troublesome side effects of cytokine release syndrome or neurotoxicity that we see with CAR-T cells that can profoundly affect patients, Fehniger said. These side effects can be life-threatening and require intensive care. Were still working to understand how NK cells are different. But if you can get the benefits of CAR-T cells with few if any of the side effects, thats a reasonable line of research to pursue. Another benefit of this safer therapy is the potential to give these cells to patients at an earlier stage in their disease, rather than using them as a last resort.

Other groups have developed CAR-NK cells, but a major difference is that other groups NK cells came from donated cord blood or induced stem cells, rather than adult donors or the patients themselves.

The other groups have artificially differentiated stem cells into something that resembles an NK cell, Fehniger said. With that strategy, theres no guarantee that those cells will have all the properties of typical mature NK cells. In contrast, were starting with adult NK cells, so were more confident that they will have all the inherent properties and behavior of adult NK cells, which we have already shown to be effective in certain types of cancer patients, especially those with leukemia. Inducing memory properties adds to their persistence and effectiveness against many cancer types.

Over the next several years, we would like to be able to scale up this process to produce enough cells for a first-in-human clinical trial, and investigate their effectiveness in different types of human blood cancers, he said.

This work was supported by the Howard Hughes Medical Institute; the National Institutes of Health (NIH), grant numbers F32CA200253, T32HL00708843, K12CA167540 and R01CA205239; and a NIH SPORE in Leukemia, grant number P50CA171063. Additional funding was provided by the Siteman Cancer Center through NIH grant number P30CA091842; the Leukemia and Lymphoma Society; the V Foundation for Cancer Research; the Childrens Discovery Institute at Washington University School of Medicine; the Jamie Erin Follicular Lymphoma Research Fund; and the Steinback Fund.

Berrien-Elliott and Fehniger are inventors on patents related to this study that have been filed by Washington University. Fehniger has received research support from ImmunityBio, Compass Therapeutics, and HCW Biologics, and advises Kiadis, Nkarta, Indapta, and Orca Biosystems. Other authors report serving as a consultant for Kiowa Hakka Kirin and C4 Therapeutics; receiving research funding from Bristol Myers-Squibb, Verastem Pharmaceuticals, Innate Pharmaceuticals, Genentech/Roche, Celgene, and Corvus Pharmaceuticals; having direct ownership of equity in and a consultancy with Wugen; serving on the consulting/advisory committee for Rivervest, Bioline, Amphivena and Bluebird, Celegene, Incyte, NeoImuneTech, and Macrogenics and ownership investment in Magenta and WUGEN.

Gang M, Marin ND, Wong P, Neal CC, Marsala L, Foster M, Schappe T, Meng W, Tran J, Schaettler M, Davila M, Gao F, Cashen AF, Bartlett NL, Mehta-Shah N, Kahl BS, Kim MY, Cooper ML, DiPersio JF, Berrien-Elliott MM, Fehniger TA. CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas. Blood. July 2, 2020.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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2 immunotherapies merged into single, more effective treatment - Washington University School of Medicine in St. Louis

Can fully shutting down the estrogen receptor make a difference in breast cancer? Olema scores $54M to find out in the clinic – Endpoints News

By Stem Cell Clinic

From tamoxifen to aromatase inhibitors to fulvestrant, theres been no lack of endocrine treatments targeted at estrogen receptor-positive breast cancer. But Olema Oncology believes theres room for more.

The San Francisco-based biotech has convinced investors to pour in $54 million to prove it.

We saw the need for a drug that could more fully shut down the estrogen receptor, Cyrus Harmon told Endpoints News. We call it a complete estrogen antagonist to distinguish from other compounds.

After iterating through multiple generations of candidates for more than a decade funded by the founders themselves, angel investors and a now-defunct pharma collaboration Olema closed its first venture round in 2018 from BVF Partners.

BVF returned to co-lead the Series B alongside Logos Capital and Janus Henderson Investors, while new investors Cormorant Asset Management, RA Capital Management, Wellington Management Company, Surveyor Capital, Venrock Healthcare Capital Partners, and Foresite Capital joined.

We were attracted to Olema by its excellent science, robust preclinical data, experienced management team, and potential to make a significant impact on what remains a large unmet need among patients with breast and other hormone-positive cancers, Gorjan Hrustanovic, principal at BVF Partners, said.

The new cash will bankroll the program Phase I/II for OP-1250, evaluating the oral pill as a single agent for patients with ER+, HER2- who have seen their cancer come back despite treatment.

If the drug does what Olema wants it to do in the first-in-human testing, the next step will be to study it as a potential backbone therapy in combinations with others.

Thereve been a number of targeted therapies for breast cancer that have been developed in the last decade or so, such as the CDK4/6 inhibitors and PI3 kinase alpha inhibitors, Harmon said.

Whereas endocrine therapy was originally always used just by itself, it appears to pair well with these new classes of drugs.

That would require more money and likely a larger team than the current 12 to run bigger studies perhaps even an IPO that Harmon says is too early to discuss. But first, they need to get into the clinic.

One step at a time, he said.

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Can fully shutting down the estrogen receptor make a difference in breast cancer? Olema scores $54M to find out in the clinic - Endpoints News

Kubota Vision Announces Research Agreement with The Research Foundation for the State University of New York for a Wearable Myopia Control Device -…

By Gene Therapy Clinics

SEATTLE--(BUSINESS WIRE)--Kubota Vision Inc. (Kubota Vision), a clinical-stage ophthalmology company and wholly-owned subsidiary of Kubota Pharmaceutical Holdings Co., Ltd. (Tokyo 4596), today announced that the company and The Research Foundation for the State University of New York (Foundation) have entered into a research agreement to conduct and carry out the testing and characterization of our investigational, wearable myopia-control device based on Kubota Glasses technology to further evaluate its effects on choroidal thickness and axial length.

Kubota Vision conducted a clinical study in early 2020 with an electronic tabletop optical projection device that embodied Kubota Glasses technology. The results of the study demonstrated that axial length decreases with the application of projected myopically-defocused images in the test eye compared to the control eye, which has not been reported in the literature. The company initiated a proof-of-concept (POC) clinical study to validate the concept of a wearable myopia-control device based on Kubota Glasses technology in June 2020. A wearable prototype is expected to be available by the end of 2020.

The Research Foundation for the State University of New York (SUNY) is the largest comprehensive university-connected research foundation in the country. SUNY is the nations largest comprehensive system of higher education with over 7,000 degree and certificate programs at 64 unique campuses serving over 400,000 students. This project will be carried out by Dr. Sharon Park Keh, an Assistant Clinical Professor at the SUNY College of Optometry, as the Principal Investigator. She has acted as a clinical investigator on various contact lens and myopia control studies and is a preceptor and instructor in the University Eye Clinics contact lens clinics.

Ryo Kubota, MD, PhD, Chairman, President and CEO of Kubota Vision Inc., stated, We are excited to collaborate with one of the historic and yet highly prestigious vision centers. The Foundations global network will provide expertise to our Kubota Glasses technology to enhance and improve its development. We are looking forward to the exciting time ahead.

Dr. Sharon Park Keh, OD, FAAO, Assistant Clinical Professor of the State University of New York, stated, I am excited to be involved in this research using such a promising and revolutionary technology for the suppression of myopia. I look forward to seeing positive results from this partnership.

About Kubota Glasses Technology

Kubota Glasses technology works to reduce the increase in axial length associated with myopia by projecting myopically-defocused virtual images generated using micro-LEDS on the peripheral visual field to actively stimulate the retina. Using this method, a clinical study utilizing a bench top device demonstrated that axial length decreases in the test eye compared to the control eye as the stimulus is applied. Passive stimulation using myopic defocus is already in use in an FDA-approved contact lens. Kubota Glasses technology leverages nanotechnology in its electronic glasses-based device and seeks to reduce the progression of myopia by actively stimulating the retina for shorter periods while maintaining central vision and not affecting daily activities. The company is planning to submit the full data for scientific publication.

About Kubota Vision Inc.

Kubota Vision Inc. is a wholly-owned subsidiary of Kubota Pharmaceutical Holdings Co., Ltd. (Tokyo 4596) committed to translating innovation into a diverse portfolio of drugs and devices to preserve and restore vision for millions of people worldwide. Kubota Pharmaceutical groups development pipeline include drug candidates for the treatment of diabetic retinopathy, Stargardt disease, and optogenetics-based gene therapy for the treatment of retinitis pigmentosa. The company is also developing a handheld OCT device for the monitoring of neovascular retinal diseases, to be used directly by patients, and wearable device for myopia control. https://www.kubotavision.com/; https://www.kubotaholdings.co.jp/en/

Cautionary Statements

Certain statements contained in this press release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements include statements regarding our expectations related to our development plans and ability to successfully develop and commercialize our product candidates and the potential efficacy, future development plans and commercial potential of our product candidates. These statements are based on current assumptions that involve risks, uncertainties and other factors that could cause the actual results, events or developments to differ materially from those expressed or implied by such forward-looking statements. These risks and uncertainties, many of which are beyond our control, include, but are not limited to: our investigational product candidates may not demonstrate the expected safety and efficacy; our pre-clinical development efforts may not yield additional product candidates; any of our or our collaborators' product candidates may fail in development, may not receive required regulatory approvals, or may be delayed to a point where they are not commercially viable; our clinical trials could be delayed; new developments in the intensely competitive ophthalmic pharmaceutical market may require changes in our clinical trial plans or limit the potential benefits of our investigational product candidates; the impact of expanded product development and clinical activities on operating expenses; adverse conditions in the general domestic and global economic markets; as well as the other risks identified in our filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date hereof and we assume no obligation to update these forward-looking statements, and readers are cautioned not to place undue reliance on such forward-looking statements. For a detailed discussion of the foregoing risks and other risk factors, please refer to our filings with the Securities and Exchange Commission, which are available on Kubota Pharmaceutical Holdings (Kubota Visions parent company) investor relations website (https://www.kubotaholdings.co.jp/en/ir/) and on the SECs website (http://www.sec.gov).

Kubota Vision, the Kubota Vision logo and Kubota are registered trademarks or trademarks of Kubota Vision Inc. or Kubota Pharmaceutical Holdings in various jurisdictions.

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Kubota Vision Announces Research Agreement with The Research Foundation for the State University of New York for a Wearable Myopia Control Device -...

Fine-tuning adoptive cell therapy for advanced cancers – Newswise

By Stem Cell Medical Center

FINDINGS

Newswise Adoptive cell transfer immunotherapy is one of the most promising new treatments for people with hard-to-treat cancers. However, the process is complex and needs fine-tuning in order to develop more treatment strategies that will work for more people.

In a new study looking at adoptive cell transfer products bearing a transgenic T-cell receptor (TCR), researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a discordant phenomenon in which a subset of patients displayed profoundly decreased expression of the transgenic TCR over time, despite the transgenic TCR being present at the DNA level. This gave rise to the observation that structural changes to the DNA via DNA methylation make it inaccessible for transcription and translation, which is an influential step in the flow of genetic information from DNA to RNA. This can be one clue into why some patients stop responding to this type of immunotherapy.

The issue is this phenomenon happens over time, said lead author Theodore Scott Nowicki, MD, PhD, clinical instructor of pediatrics and hematology/oncology at the David Geffen School of Medicine at UCLA. Were hoping this can help inform the design of future generations of these types of therapies and pinpoint different vectors that might be more or less vulnerable to this phenomenon.

JOURNAL

The study waspublished onlinein Cancer Discovery, a journal of the American Association for Cancer Research.

BACKGROUND

Adoptive cell transfer immunotherapy works by taking a patients own T cells, which are one of the components of the immune system, and genetically modifying them in the laboratory to target tumor-specific antigens on the surface of the tumor. The new army of tumor-specific T cells are then reinfused back into the patient to help attack the cancer.

A key component of adoptive cell transfer therapy requires genetically modifying T cells to target cancer cells. This is often done with viral transduction agents with either lentivirus- or retrovirus-based products to express either a cancer antigen-specific TCR or chimeric antigen receptor (CAR).

In order to develop more efficient cell therapies, Nowicki and colleagues are studying the genetic mutations of T cells to understand the structural changes to DNA over time. This could reveal why adoptive cell transfer therapy is more likely to work in some patients versus others and help inform the future design of next-generations of the therapy.

METHOD

The team analyzed 16 clinical transgenic adoptive cell therapy samples collected before and during treatment from patients with melanoma and sarcoma. This allowed the team to look at the expression of the transgenic TCR at the DNA and protein level. It gave them insight into what proportion of the cells displayed impaired expression of the transgenic TCR. They were then able to assess the degree of DNA methylation present in the retroviral vectors promoter region over time, and correlate this degree of DNA methylation with repression of the transgenic TCR.

IMPACT

The study can help researchers in the design of future generations of cellular immunotherapies to help treat people with advanced cancers.

AUTHORS

The studys lead and senior author is Dr. Nowicki. The study was conducted under the mentorship of Dr. Antoni Ribas, professor of medicine and director of the tumor immunology program at the UCLA Jonsson Comprehensive Cancer Center. Both Dr. Nowicki and Dr. Ribas are members of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research. Other authors include Colin Farrell, Marco Morselli, Liudmilla Rubbi, Katie Campbell, Mignonette Macabali, Beata Berent-Maoz, Begona Comin-Anduix and Matteo Pellegrini, all of UCLA.

FUNDING

The research was funded in part by grants from the National Institutes of Health, the Tower Cancer Research Foundation, the Hyundai Hope on Wheels foundation, the Parker Institute for Cancer Immunotherapy and the Ressler Family Fund.

***

The UCLA Jonsson Comprehensive Cancer Center has more than 500 researchers and clinicians engaged in cancer research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the UCLA Jonsson Comprehensive Cancer Center is dedicated to promoting research and translating basic science into leading-edge clinical studies.

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Ascentage Pharma Announces First Patient Dosed in the Phase Ib Study of MDM2-p53 Inhibitor APG-115 as Single Agent and in Combinations for the…

By Stem Cell Treatment

SUZHOU, China and ROCKVILLE, Md., July 22, 2020 /PRNewswire/ -- Ascentage Pharma (6855.HK), a globally focused, clinical-stage biotechnology company engaged in developing novel therapies for cancers, chronic hepatitis B (CHB), and age-related diseases, today announced that the Phase Ib study of the company's novel MDM2-p53 inhibitor candidate APG-115 as a single agent or in combinations for the treatment of Chinese patients with relapsed/refractory acute myeloid leukemia (r/r AML), or relapsed/progressed high/very high risk myelodysplastic syndrome (MDS) has dosed its first patient in China. As the first MDM2-p53 inhibitor entering clinical studies for the treatment of solid tumors in China, this is the first study of APG-115 in patients with hematologic malignancies.

This multicenter Phase Ib clinical study in China is designed to evaluate the safety, pharmacokinetics, and pharmacodynamics of APG-115 as a single agent or in combination with azacitidine or cytarabine in patients with hematologic malignancies, including r/r AML and relapsed/progressed high/very high risk MDS.

AML is a clonal proliferative disease of the bone marrow, of which the incidence rate increases with age. AML is the most common type of leukemia in China, with an incidence rate of 1.62-2.32 cases per 100,000[1]. The standard induction therapy for AML comprises the "7+3" regimen (7 days of cytarabine plus 3 days of anthracycline drugs), but up to 40% of newly diagnosed AML patients do not achieve complete response (CR) during initial induction therapy, which is considered as refractory, or relapse within 6 months after achieving CR[2].

MDS is a heterogeneous hematopoietic disease caused by abnormal pluripotent stem cells, and the condition is characterized by poor hematopoietic function, bone marrow failure, reduction in peripheral blood cells, and reduced survival rates. The incidence rate of MDS in China is approximately 5 cases per 100,000. Although hypomethylating agents can produce a high response rate in patients with MDS, many patients eventually develop drug resistance to hypomethylating agents. Patients who have developed the acquired drug resistance commonly face a very poor prognosis. In patients with high-risk MDS, treatment failure with hypomethylating agents is associated with an average survival of less than 6 months[3]. As a result, both refractory/progressed AML and MDS represent an urgent medical need for more effective therapies.

APG-115 is an orally administered, selective, small-molecule inhibitor of the MDM2-p53 protein-protein interaction (PPI). APG-115 has strong binding affinity to MDM2 and is designed to activate tumor suppression activity of p53 by blocking the MDM2-p53 PPI. APG-115 is the first MDM2-p53 inhibitor entering clinical development in China, with multiple ongoing clinical studies in solid tumors in China and the US. At present, APG-115 is being investigated in a range of hematologic malignancies globally.

"Currently, there remains to be significant unmet medical needs in the treatment of hematologic malignancies, including AML and MDS," said Dr. Yifan Zhai, Chief Medical Officer of Ascentage Pharma. "We have also noticed that drug development targeting the MDM2-p53 pathway has received growing interest. As the first MDM2-p53 inhibitor entering clinical study in China, APG-115 has already demonstrated favorable safety profiles and preliminary efficacy in solid tumors. We will actively explore APG-115's therapeutic potential in hematologic malignancies, to hopefully provide more options of AML and MDS treatment to patients in China and around the world."

References:

1.Chang R, Wu S, Chen W, et al. Analysis on epidemiological characteristics of leukemia in Gansu Province from 2003 to 2012 [Article in Chinese]. Modern Preventive Med. 2014;41(21):3841-04.

2.Thol F, Schlenk RF, Heuser M, Ganser A. 2015. How I treat refractory and early relapsed acute myeloid leukemia. Blood 126: 319-27

3.Prebet T, Gore SD, Esterni B, Gardin C, Itzykson R, et al. 2011. Outcome of high-risk myelodysplastic syndrome after Azacitidine treatment failure. J Clin Oncol 29: 3322-7

About APG-115

APG-115 is an orally administered, selective, small-molecule inhibitor of the MDM2-p53 PPI. APG-115 has strong binding affinity to MDM2 and is designed to activate p53 tumor suppression activity by blocking the MDM2-p53 PPI. Ascentage Pharma has previously commenced three clinical trials of APG-115 in the US, including a Phase I study as single agent, a Phase Ib/II study in combination with pembrolizumab for treatment of metastatic melanoma and other advanced solid tumors, and a Phase I/II study as a single agent or in combination with chemotherapy for treatment of salivary gland cancer. APG-115 is the first MDM2-p53 inhibitor to enter clinical studies in China. A Phase I study as a single agent, and a Phase Ib study as a single agent or in combination with chemotherapy for treatment of AML (acute myeloid leukemia) or MDS (myelodysplastic syndrome) are ongoing in China.

About Ascentage Pharma

Ascentage Pharma (6855.HK) is a globally, clinical-stage biotechnology company engaged in developing novel therapies for cancers, CHB, and senesce diseases. On October 28, 2019, Ascentage Pharma was listed on the Main Board of the Stock Exchange of Hong Kong Limited with the stock code: 6855.HK.

Ascentage Pharma focuses on developing therapeutics that inhibit protein-protein interactions to restore apoptosis, or programmed cell death. The company has built a pipeline of eight clinical drug candidates, including novel, highly potent Bcl-2, and dual Bcl-2/Bcl-xL inhibitors, as well as candidates aimed at IAP and MDM2-p53 pathways, and next-generation tyrosine kinase inhibitors. Ascentage Pharma is also the only company in the world with active clinical programs targeting all three known classes of key apoptosis regulators. The company is conducting more than 30 Phase I/II clinical trials in the US, Australia, and China. The company's core drug candidate HQP1351 was recently granted orphan drug and fast-track designations by the US Food and Drug Administration (FDA), and a New Drug Application for HQP1351 has been submitted in China. APG-2575, another key drug candidate of the company, was recently granted orphan drug designation by the FDA.

Forward-Looking Statements

The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events, or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development.

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Ascentage Pharma Announces First Patient Dosed in the Phase Ib Study of MDM2-p53 Inhibitor APG-115 as Single Agent and in Combinations for the...

Latest News On the Covid-19 impact on Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Trade Overview, Industry Demand and…

By Stem Cell Treatment

The global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market is carefully researched in the report while largely concentrating on top players and their business tactics, geographical expansion, market segments, competitive landscape, manufacturing, and pricing and cost structures. Each section of the research study is specially prepared to explore key aspects of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market. For instance, the market dynamics section digs deep into the drivers, restraints, trends, and opportunities of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market. With qualitative and quantitative analysis, we help you with thorough and comprehensive research on the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market. We have also focused on SWOT, PESTLE, and Porters Five Forces analyses of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market.

Leading players of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market are analyzed taking into account their market share, recent developments, new product launches, partnerships, mergers or acquisitions, and markets served. We also provide an exhaustive analysis of their product portfolios to explore the products and applications they concentrate on when operating in the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market. Furthermore, the report offers two separate market forecasts one for the production side and another for the consumption side of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market. It also provides useful recommendations for new as well as established players of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market.

Final Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Report will add the analysis of the impact of COVID-19 on this Market.

Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market competition by top manufacturers/Key player Profiled: Janssen, Qiagen, Advanced Cell Diagnostics, ApoCell, Biofluidica, Clearbridge Biomedics, CytoTrack, Celsee, Fluxion, Gilupi, Cynvenio, On-chip, YZY Bio, BioView, Fluidigm, Ikonisys, AdnaGen, IVDiagnostics, Miltenyi Biotec, ScreenCell, Silicon Biosystems

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The global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) market was valued at $XX million in 2019, and Research analysts predict the global market size will reach $XX million by the end of 2029, growing at a CAGR of XX% between 2019 and 2029.

Since the COVID-19 virus outbreak in December 2019, the disease has spread to over 210 countries and territories around the world and 2 international conveyances. The global impacts of COVID-19 are already starting to be felt, and will significantly affect this industry in 2020.

This report analyses the impact of COVID-19 on this industry. COVID-19 can affect the global market in 3 ways: by directly affecting production and demand, by creating supply chain and market disruption, and by its financial impact on enterprises and financial markets.

This report provides detailed historical analysis of global market for Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) from 2014-2019, and provides extensive market forecasts from 2020-2029 by region/country and subsectors. It covers the sales volume, price, revenue, gross margin, historical growth and future perspectives in the Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) market.

Segmentation by Product:

CellSearch Others

Segmentation by Application:

Breast Cancer Diagnosis and Treatment Prostate Cancer Diagnosis and Treatment Colorectal Cancer Diagnosis and Treatment Lung Cancer Diagnosis and Treatment Other Cancers Diagnosis and Treatment

Competitive Analysis:

Global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market for Global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

Scope of the Report: The all-encompassing research weighs up on various aspects including but not limited to important industry definition, product applications, and product types. The pro-active approach towards analysis of investment feasibility, significant return on investment, supply chain management, import and export status, consumption volume and end-use offers more value to the overall statistics on the Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market. All factors that help business owners identify the next leg for growth are presented through self-explanatory resources such as charts, tables, and graphic images.

The report offers in-depth assessment of the growth and other aspects of the Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) market in important countries (regions), including:

North America(United States, Canada and Mexico)

Europe (Germany, France, UK, Russia and Italy)

Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia)

South America (Brazil, Argentina, Colombia)

Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

Our industry professionals are working reluctantly to understand, assemble and timely deliver assessment on impact of COVID-19 disaster on many corporations and their clients to help them in taking excellent business decisions. We acknowledge everyone who is doing their part in this financial and healthcare crisis.

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Table of Contents

Report Overview:It includes major players of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market covered in the research study, research scope, and Market segments by type, market segments by application, years considered for the research study, and objectives of the report.

Global Growth Trends:This section focuses on industry trends where market drivers and top market trends are shed light upon. It also provides growth rates of key producers operating in the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market. Furthermore, it offers production and capacity analysis where marketing pricing trends, capacity, production, and production value of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market are discussed.

Market Share by Manufacturers:Here, the report provides details about revenue by manufacturers, production and capacity by manufacturers, price by manufacturers, expansion plans, mergers and acquisitions, and products, market entry dates, distribution, and market areas of key manufacturers.

Market Size by Type:This section concentrates on product type segments where production value market share, price, and production market share by product type are discussed.

Market Size by Application:Besides an overview of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market by application, it gives a study on the consumption in the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market by application.

Production by Region:Here, the production value growth rate, production growth rate, import and export, and key players of each regional market are provided.

Consumption by Region:This section provides information on the consumption in each regional market studied in the report. The consumption is discussed on the basis of country, application, and product type.

Company Profiles:Almost all leading players of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market are profiled in this section. The analysts have provided information about their recent developments in the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market, products, revenue, production, business, and company.

Market Forecast by Production:The production and production value forecasts included in this section are for the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market as well as for key regional markets.

Market Forecast by Consumption:The consumption and consumption value forecasts included in this section are for the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market as well as for key regional markets.

Value Chain and Sales Analysis:It deeply analyzes customers, distributors, sales channels, and value chain of the global Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market.

Key Findings: This section gives a quick look at important findings of the research study.

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Latest News On the Covid-19 impact on Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Trade Overview, Industry Demand and...

The global cell expansion market size is estimated to be USD 14.9 billion in 2020 and projected to reach USD 30.1 billion by 2025, at a CAGR of 15.1%…

By Adult Stem Cells

Increasing incidence of chronic diseases, and government investments for cell-based research are set to drive the cell expansion market.

NEW YORK, July 22, 2020 /PRNewswire/ --

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The global cell expansion market size is estimated to be USD 14.9 billion in 2020 and projected to reach USD 30.1 billion by 2025, at a CAGR of 15.1%. Growth in this market is largely driven by the increasing incidence of chronic diseases, government investments for cell-based research, growing focus on personalized medicine, increasing focus on R&D for cell-based therapies, and increasing GMP certifications for cell therapy production facilities. On the other hand, ethical concerns regarding research in cell biology are expected to limit market growth to a certain extent in the coming years.

By instruments type, the cell expansion supporting equipment accounted for the fasted growing product segment of the cell expansion market The instruments segment includes cell expansion supporting equipment, bioreactors, and automated cell expansion systems.The cell expansion supporting equipment market includes flow cytometers, cell counters and hemocytometers, centrifuges, and other supporting equipment.

They are used in cell culture processes for isolating, culturing, scaling-up, and extracting biological products. These instruments are essential in laboratories and institutes for conducting research and analyzing the cell structure and function for cell therapy research. By cell type, the human cells segment accounted for the largest share of the cell expansion market

Based on cell type, the cell expansion market is segmented into human cells and animal cells.The human cells segment includes stem cells and differentiated cells.

The stem cells segment is further classified into adult stem cells, ESCs, and iPSCs. The human cells segment accounted for the larger share of the cell expansion market majorly due to the increasing investments by public and private organizations for research on human cells, growing application areas of human stem cells, and the growing incidence of diseases such as cancer.

Asia Pacific: The fastest-growing region in the cell expansion market. The Asia Pacific market is projected to grow at the highest CAGR during the forecast period, mainly due to the increasing focus of players on emerging Asian markets, increasing incidence of chronic and infectious diseases, rising geriatric population, and government initiatives for infrastructural improvements of healthcare facilities are driving the growth of the cell expansion market in this region.

North America: the largest share of the cell expansion market North America accounted for the largest share of the cell expansion market. The large share of this segment can primarily be attributed to the rising incidence of cancer, increasing government funding, rising research activates on stem cell therapies, growing awareness regarding advanced treatment methods, growing geriatric population, and the strong presence of industry players in the region.

Breakdown of primaries The study contains insights from various industry experts, ranging from component suppliers to Tier 1 companies and OEMs. The break-up of the primaries is as follows: By Company Type Tier 1- 70%, Tier 2- 20% and Tier 3 - 10% By Designation C level Executives- 30%, Directors- 20%, Others - 50% By Region North America - 35%, Europe - 24%, APAC 25%, RoW- 16%

The cell expansion market is dominated by a few globally established players such as Thermo Fisher Scientific, Inc. (US), Danaher (US), Becton, Dickinson and Company (US), Lonza (Switzerland), Corning, Inc. (US), Merck KGaA (Germany), Sartorius Stedim Biotech (France), Getinge AB (Sweden) Terumo Corporation (Japan), Miltenyi Biotec (Germany), PromoCell GmbH (Germany), Takara Bio Inc. (Japan), Solida Biotech GmBH (Germany), HiMedia Laboratories (India), Getinge AB, REPROCELL Inc. (Japan), Kohjin-Bio (Japan), Pierre Gurin (France), Cellexus Ltd.(UK), Eppendorf AG (Germany), CellGenix GmbH (Germany), iXCells Biotechnologies (US), Neuromics (US), Celltainer Biotech B.V. (Netherlands), and G&G Technologies (US).

Research Coverage: The report segments the cell expansion market based on region (Asia Pacific, Europe, North America, and RoW), product (consumables and instruments), cell type (human cells and animal cells), application (regenerative medicine and stem cell research, cancer and cell-based research and other applications), and end user (research institutes, biotechnology and biopharmaceutical companies, cell banks, and other end users). The report also provides a comprehensive review of market drivers, restraints, and opportunities in the cell expansion market.

Key Benefits of Buying the Report: The report will help the leaders/new entrants in this market with information on the closest approximations of the revenue numbers for the overall market and the sub-segments.This report will help stakeholders understand the competitive landscape and gain more insights to better position their businesses and plan suitable go-to-market strategies.

The report also helps stakeholders understand the pulse of the cell expansion market and provides them information on key market drivers, restraints, challenges, and opportunities.

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The global cell expansion market size is estimated to be USD 14.9 billion in 2020 and projected to reach USD 30.1 billion by 2025, at a CAGR of 15.1%...

Global Induced Pluripotent Stem Cells (iPSCs) Market Evenly Poised To Reach A Market Value of USD 2610.10 million By Share, Size and Leading Players…

By Induced Pluripotent Stem Cells

Few of the major competitors currently working in global induced pluripotent stem cells market areFUJIFILM Holdings Corporation, Astellas Pharma Inc, Fate Therapeutics, Bristol-Myers Squibb Company, ViaCyte, Inc., CELGENE CORPORATION, Vericel Corporation, KCI Licensing, Inc, STEMCELL Technologies Inc., Japan Tissue Engineering Co., Ltd., Organogenesis Holdings Inc, Lonza, Takara Bio Inc., Horizon Discovery Group plc, Thermo Fisher Scientific.

How does this market Insights help?

Key Developments in the Market:

In March 2018, Kaneka Corporation announced that they have acquired a patent in the Japan for the creation of the method to mass-culture pluripotent stem cells including iPS cells and ES cells. This will help the company to use the technology to produce high quality pluripotent stem cells which can be used in the drug and cell therapy.

In March 2015, Fujifilm announced that they have acquired Cellular Dynamics International. The main aim of the acquisition is to expand their business in the iPS cell-based drug discovery support service with the use of CDS technology. It will help them to product high- quality automatic human cells with the help of the induced pluripotent stem cells. This will help the company to be more competitive in the drug discovery and regenerative medicine.

Key questions answered in the Global Induced Pluripotent Stem Cells (iPSCs) Market report include:

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Breakdown Of Global Induced Pluripotent Stem Cells (iPSCs) Market

By Cell Type

Hepatocytes

Fibroblasts

Keratinocytes

Amniotic Cells

Neurons

Others

By Application

Drug Development

Regenerative Medicine

Toxicity Testing

Academic Research

By End-User

Academic and Research Institutes

Biotechnology Companies

Others

By Geography

North America

South America

Europe

Asia-Pacific

Middle East & Africa

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Global Induced Pluripotent Stem Cells (iPSCs) Market Evenly Poised To Reach A Market Value of USD 2610.10 million By Share, Size and Leading Players...

Global Induced Pluripotent Stem Cells Market 2020 Segmentation Trend, CAGR Status, Growth, Analysis and Forecast to 2026 – Cole of Duty

By Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells Market Production by Regions:

The analyzed data on the Induced Pluripotent Stem Cells market help you put up a brand within the industry while competing with the giants. This report provides insights into a dynamic competitive environment. It also offers a progressive viewpoint on different factors driving or restricting market growth.

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In this study, the years considered to estimate the market size of Induced Pluripotent Stem Cells Market:

Questions Answered in the Induced Pluripotent Stem Cells Market Report:

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Detailed TOC of Global Induced Pluripotent Stem Cells Market Trends, Status and Forecast 2020-2026

1 Induced Pluripotent Stem Cells Market Overview

1.1 Product Overview and Scope of Induced Pluripotent Stem Cells

1.2 Covid-19 Impact on Induced Pluripotent Stem Cells Market Production Growth Rate Segment by Type

1.3 Covid-19 Impact on Induced Pluripotent Stem Cells Segment by Application

1.4 Covid-19 Impact on Global Induced Pluripotent Stem Cells Market Size Estimates and Forecast by Region

1.5 Covid-19 Impact on Global Induced Pluripotent Stem Cells Market Growth Prospects

1.5.1 Global Induced Pluripotent Stem Cells Revenue Estimates and Forecasts (2015-2026)

1.5.2 Global Induced Pluripotent Stem Cells Production Capacity Estimates and Forecasts (2015-2026)

1.5.3 Global Induced Pluripotent Stem Cells Production Estimates and Forecasts (2015-2026)

1.6 Coronavirus Disease 2019 (Covid-19) Impact Will Have a Severe Impact on Global Growth

1.6.1 Covid-19 Impact: Global GDP Growth, 2019, 2020 and 2021 Projections

1.6.2 Covid-19 Impact: Commodity Prices Indices

1.6.3 Covid-19 Impact: Global Major Government Policy

1.7 The Covid-19 Impact on Induced Pluripotent Stem Cells Industry

1.8 COVID-19 Impact: Induced Pluripotent Stem Cells Market Trends

2 Covid-19 Impact on Market Competition by Manufacturers

2.1 Global Induced Pluripotent Stem Cells Market Share by Manufacturers (2015-2020)

2.2 Global Induced Pluripotent Stem Cells Revenue Share by Manufacturers (2015-2020)

2.3 Market Share by Company Type (Tier 1, Tier 2 and Tier 3)

2.4 Global Induced Pluripotent Stem Cells Average Price by Manufacturers (2015-2020)

2.5 Manufacturers Induced Pluripotent Stem Cells Production Sites, Area Served, Product Types

2.6 Induced Pluripotent Stem Cells Market Competitive Situation and Trends

2.6.1 Induced Pluripotent Stem Cells Market Concentration Rate

2.6.2 Global Top 3 and Top 5 Players Market Share by Revenue

2.6.3 Mergers & Acquisitions, Expansion

3 Covid-19 Impact on Production and Capacity by Region

3.1 Global Induced Pluripotent Stem Cells Market Share by Regions (2015-2020)

3.2 Global Induced Pluripotent Stem Cells Revenue Market Share by Regions (2015-2020)

3.3 Global Induced Pluripotent Stem Cells Production Capacity, Revenue, Price and Gross Margin (2015-2020)

3.4 North America Induced Pluripotent Stem Cells Production

3.4.1 North America Induced Pluripotent Stem Cells Production Growth Rate (2015-2020)

3.4.2 North America Induced Pluripotent Stem Cells Production Capacity, Revenue, Price and Gross Margin (2015-2020)

3.5 Europe Induced Pluripotent Stem Cells Production

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