Scientists have made an important discovery for the treatment of male infertility – The Saxon
Valery LEBOVKA, FACTS
Scientists from the U.S. made the discovery, which could subsequently solve the problem of male infertility, which may cause including disease coronavirus.
In particular, researchers have proposed of stem cells to grow a large number of blanks male sexual Taurus, which can be used for the treatment of infertility.
Description of the study published the scientific journal Proceedings of the National Academy of Sciences.
Now we are able to support the livelihoods of these cells for two to four weeks. The next task is to figure out how to get them to breed and live longer, you need to apply them in practice, said one of the authors, Professor University of California, San Diego (USA), miles Wilkinson.
According to the world health organization (who), about 10% of couples in developed and developing countries are unable to have children due to disorders in the reproductive system. As observations show doctors among men and women in the proportion of infertile are approximately equal, and most of them lose the ability to conceive a child at the age of 40-55 years.
Mechanisms of development of infertility in most cases remain unknown because of the complexity and poorly known genetic factors that control the production of ova and spermatozoa, as well as the first phases of development of the embryo. Now scientists are trying to figure out these mechanisms, trying to turn stem cells into analogs of the germ cells and various forms of embryos.
Wilkinson and his colleagues have solved one of these problems. They learned how to grow the so-called spermatogonia A-type one of types of stem cells that live in the male sex glands. They constantly multiply and serve as a kind of reservoirfrom which are constantly replenished stocks of spermatocytes stub future sperm.
As shown by experiments on animals with transplantation of these cells can be eliminated from the many forms of infertility. The problem, however, was the fact that scientists did not know how to distinguish these cells from other cell types that live in the testes, as well as to cultivate them by artificial means using reprogrammed stem cells.
Recently, as noted by Wilkinson, his team solved this problem. Scientists have developed a technique, which can be used to determine the type of each individual cellbased on unique sets of RNA, characteristic only for them. Using this technique, scientists tried to isolate pure culture of spermatogonia A-type and to understand which genes were active within them.
After analyzing three dozen samples of similar cells obtained from healthy donors, the researchers came to the conclusion that the main obstacle to their growth is a chain of genes AKT, which causes a stem cell to turn into a blank sperm.
Locking her job, Wilkinson and his colleagues were able to grow a large number of spermatogonia A-type and to maintain their existence for several weeks. Further experiments with these cells, as scientists hope will pave the way for the creation of the first effective techniques for using stem cells to treat male infertility.
Earlier, the FACTS wrote that during the communication with the readers of our publication, the medic answered questions about what types of infertility are the most common; it is difficult if full the woman is harder to get pregnant; how to prepare for pregnancy and several others.
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Scientists have made an important discovery for the treatment of male infertility - The Saxon