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Restorative therapies for erectile dysfunction: Where are we at in 2020? – Urology Times

By Stem Cell Medicine

Restorative therapies are an exciting area of potential treatments for patients with erectile dysfunction (ED); however, there is a paucity of clinical data regarding their efficacy and safety, according to Trinity Bivalacqua, MD, PhD.1

The goal of restorative therapies in ED is to reestablish whole-organ function and reverse penile dysfunction using regenerative medicine technology, Bivalacqua explained in a presentation during the 2020 AUA Virtual Experience. The restorative therapies for ED include platelet rich plasma (PRP), stromal vascular fraction (SVF), amniotic fluid (AF), and stem cells (mesenchymal cells, adipose derived stem cells, amniotic stem cells, and cord blood stem cells).

Restorative therapies are particularly relevant for patients who have had radical prostatectomies and have post-prostectomy ED, as well as for patients with severe ED as it relates to peripheral vascular disease and diabetes, said Bivalacqua, director of Urologic Oncology at Johns Hopkins Univsersity.

Although the potential of restorative therapy to treat ED itself, and not just its symptoms, has created a lot of buzz in the urology community, Bivalacqua said the lack of data in the literature backing the efficacy and safety of the technology means it should currently be reserved for clinical trials. Accordingly, this is the current position of the Sexual Medicine Society of North America (SMSNA), which sponsored Bivalacquas discussion:

Given the lack of regulatory agency approval for any restorative (regenerative) therapies for the treatment of ED and until such time as approval is granted, SMSNA believes that the use of shock waves or stem cells or platelet rich plasma is experimental and should be conducted under research protocols (clinical trials) in compliance with Institutional Review Board approval.

In his discussion during the AUA online platform, Bivalacqua discussed the limited available evidence in the literature for each ED-focused restorative therapy and the next steps for this technology.

PRP is the most common restorative therapy used for ED. This treatment can be applied through intracavernous injection. Although he did not make a recommendation for its use outside of clinical trials, Bivalacqua said PRP Falls under the HCT/P 361 exemption proposed by the FDA. This means in clinical practice you can usePRPwithout gaining FDA approval. As long as the tissue/biospecimen is not manipulated once its removed from the patient, it is then exempt from FDA approval and clinical trials.

With PRP, a clinician can use a normal centrifuge to isolate the PRP, which can then be injected. It does not have a specific CPT billing code, but can be categorized under a nonspecific code for blood transfusion and reinfection. For the most part, it is not covered by insurance or Medicare, with the post common payment form being cash, said Bivalacqua. Regarding clinical evidence, there have been no randomized clinical trials of PRP.

Bivalacqua said there is 1 peer-reviewed trial2 of PRP in the literature, but it only had safety results. The study assessed PRP in 17 patients with various urological diseases, including 4 patients with ED. The results showed that PRP injections were safe overall, with some mild bruising, but no serious adverse events.

Autologous SVF involves the removal of adipose tissues, often through liposuction. The removed tissues are then separated into individual components, with the key components, such as adipose-derived stemcells(ADSCs)and endothelial precursorcells(EPCs), being reinjected into the patient. ADSCs and EPCs release beneficial cytokines and growth hormones, which promote tissue survival, angiogenesis, and further stem cell recruitment, said Bivalacqua.

Since SVF involves the patient specimens being manipulated, unlike with PRP, this procedure does not fall under the FDA HCT/P 361 exemption and no SVF devices are currently FDA approved. There is also no clinical trial data in the literature supporting the efficacy of SVF.

Some trials have been published showing promise for low-intensity shockwave therapy as a treatment for patients with ED. One study3 looked at the long-term efficacy of low-intensity shockwave therapy using an electrohydraulic device in 156 patients who initially had a successful outcome according to the minimal clinically important difference on the International Index of Erectile Function-Erectile Function (IIEF-EF). Patients were assessed per the IIEF-EF at 6, 12, 18, and 24 months.

Although the treatment was successful in 63.5% (n = 99) of patients at 1 month after treatment, efficacy gradually decreased over time. Among the 99 patients who initially responded, only 53 (53.5%) were still experiencing a beneficial treatment effect at 2 years follow-up.

They found that there was very little durability of the shock-wave therapy in patients with severe ED. Whatever effect was seen was then mitigated at 24 months, said Bivalacqua. Those patients with non-severe EDthose who would typically respond to PDE-5 inhibitorshad a more efficacious response.

Another study4 of low-intensity shockwave therapy used an electromagnetic device to treat patients with ED. There were 87 evaluable patients who were randomized to receive 1 of 2 shockwave regimens: Group A (n= 45) received 3600 shocks (720/day) over 5 days and Group B (n = 42) received 3600 shocks over 2 weeks (600 over 3 days each week). The was a statistically significant improvement in IIEF-EF score for both groups, with a mean increase of 2.7 in both group A and group B (P <.05). There was also a statistically significant improvement in Erectile Hardness Scale score in both arms at 0.6 points in group A and 0.5 points in group B.

Although the improvements were statistically significant, the benefits were minor, leaving Bivalacqua to ask, The question is, Is this clinically significant? My perspective on this is that this did not include a sham group and the improvement was in patients who were typically PDE-5inhibitorresponders. But I do think we have to acknowledge that using the electromagnetic probe, which causes a lower peak energy, may be safer for patients.

While it is an exciting field, Bivalacqua noted that there is an ugly side to restorative therapies for ED

The global use of PRP, especially in North America, is very high, despite the lack of any clinical evidence that it is effective or safe, said Bivalacqua, adding, Some practitioners are cashing in on the hype of shockwave therapy even though the treatments are not FDA approved.

To combat these issues, Bivalacqua said several questions need to be answered in the literature. The next steps with restorative therapies are determining optimal dosing regimens; assessing the total power and number of shocks with shockwave devices; determining the optimal device choiceelectromagnetic versus electrohydraulic; and evaluating the duration of studies and role of maintenance therapy. But more importantly, we need to have a sham in randomized controlled trials.

Bivalacqua also provided several suggestions on how the efficacy of the available restorative therapies could be improved.

The future is combination therapy, where we include low-intensity shockwave therapy with the injection of either SVF or stem cells. And we have to include a maintenance phase. Other protein- and gene-based therapies, such as SDF-1, which hone stem cells, are obviously an important next step. And neurotrophic factors placed at the time of radical prostatectomy are the only way that we are going to be able to regenerate nerves post prostatectomy.

References

1. Bivalacqua T. State-of-the-Art Lecture: Update on Clinical Trials on Restorative Therapies for Erectile Dysfunction. Presented during 2020 AUA Virtual Experience. June 27-28, 2020.

2. Matz EL, Pearlman AM, Terlecki RP, et al. Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions. Investig Clin Urol. 2018;59(1):61-65. doi: 10.4111/icu.2018.59.1.61

3. Kitrey ND, Vardi Y, Appel B, et al. Low intensity shock wave treatment for erectile dysfunction-how long does the effect last? J Urol 2018;200(1):167-170.doi: 10.1016/j.juro.2018.02.070

4. Patel P, Katz J, Lokeshwar SD, et al. Phase II randomized, clinical trial evaluating 2 schedules of low-intensity shockwave therapy for the treatment of erectile dysfunction. Sex Med. 2020 Jun; 8(2): 214222. doi: 10.1016/j.esxm.2020.01.010

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Restorative therapies for erectile dysfunction: Where are we at in 2020? - Urology Times

Local scientists create ‘mini livers’ to trial therapies for liver diseases – The Straits Times

By Adult Stem Cells

Local scientists here have successfully created human liver organoids, or "mini livers", to help them develop and trial therapies for various liver diseases.

This is part of a research collaboration between the Agency for Science, Technology and Research's Genome Institute of Singapore (GIS) and the National University of Singapore (NUS). The liver organoids, each with a diameter of around 0.5mm, are able to capture the functional and structural features of the human liver.

Cultivated in vitro in a petri dish, the organoids are grown outside the body from stem cells, which are initially reprogrammed from human skin cells over a three-month period.

To better understand the effects of non-alcoholic fatty liver disease (NAFLD) on the organ, the liver organoid cells are supplemented with a fatty acid-rich nutrient, to replicate the effect of high carbohydrate and fatty food intake, which is said to be the primary cause of the disease.

Characterised by the building up of fat in the livers of people who consume little to no alcohol, the disease is often associated with obesity and Type 2 diabetes, affecting up to a third of the local adult population.

When fatty food is consumed, hepatocytes, which make up around 80 per cent of the cells within the liver, help to store and process excess fats.

Cholesterol from these fats are then secreted into liver canals known as the bile canaliculi, before reaching the gastrointestinal system where it is absorbed into the blood.

However, too much fat being accumulated in the liver may result in disruptions to the structure and function of the hepatocyte cells, while the bile canaliculi may end up being shortened or diminished.

When combined, this could lead to liver injury, eventually hampering the organ's function over time.

In more severe cases, the disease could lead to liver cancer and liver cirrhosis, where the liver no longer functions properly, owing to long-term damage.

Liver organoids developing in a dish (far left) and a visualisation of different cell types and liver structures in the organoids, including hepatocyte cells and bile canaliculi (both in green). PHOTO: GENOME INSTITUTE OF SINGAPORE

Associate Professor Dan Yock Young of NUS' Yong Loo Lin School of Medicine said: "Patients with early stage NAFLD remain largely asymptomatic, and the disease progresses silently over the years.

"What drives the disease progression and liver injury remains largely unknown. The development of advanced human liver models of the disease will provide a critical tool for researchers to identify molecular drivers of the disease."

Through the liver organoid model, scientists can observe and capture molecular and structural changes of the liver as the disease progresses - all within the course of a week.

In addition, the organoid model could also serve as a useful tool for drug testing and screening, given that there are currently no approved therapies for NAFLD.

As the disease is closely associated with obesity, the treatment recommendations for patients with liver disease are often dietary and lifestyle changes.

Professor Ng Huck Hui, senior group leader at GIS, said: "The increase in prevalence of liver disease and the lack of therapeutics place a huge burden on healthcare systems worldwide.

"There is a dire need to better understand liver biology in order to develop advanced cellular models of disease, and novel therapies."

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Local scientists create 'mini livers' to trial therapies for liver diseases - The Straits Times

Out-of-Pocket Costs Often Higher Than Expected for Patients with Cancer Participating on Clinical Trials – Curetoday.com

By Stem Cell Doctors

According to the lead study investigator, work needs to be done to ensure financial toxicity is not a deterrent to clinical trial enrollment and that trial sponsors and payers should consider trial expense reimbursement.

Clinical trials have additional visits and costs compared to the standard of care, Dr. Ryan W. Huey, an assistant professor in the department of gastrointestinal medical oncology at The University of Texas MD Anderson Cancer Center in Houston, said during a pre-recorded presentation of the data. And while financial toxicity has been well described for patients with cancer, it is less well established for patients who enroll in clinical trials.

To evaluate financial toxicity, which is the direct and indirect impact of health care costs that lead to significant financial burden, and out of-of-pocket costs for patients with cancer enrolled in early phase clinical trials, Huey and colleagues surveyed patients who were on a trial for more than a month. The goal, Huey said during the presentation, was to talk to patients who accurately understood what their monthly expenses were while on their respective trial.

The researchers collected data regarding patient demographics, including, but not limited to, patient and disease characteristics, as well as insurance status.

Using the 12-question COmprehensive Score for Financial Toxicity (COST)Functional Assessment of Chronic Illness Therapy (FACIT) survey, the researchers assessed the financial toxicity that 213 patients (with a median age of 59 years) in early-phase clinical trials experienced. More than half of the trial participants surveyed were female (59%) and more than three-fourths (79%) were non-Hispanic white. Other characteristics patients were grouped by included yearly household income, type of insurance, employment status and length of time spent on current trial.

More than half of the participants (55%) had employer-provided insurance, 38% had Medicare, 11% had personally purchased insurance and the remaining participants had either Medicaid (2%), VA-provided insurance (4%), personally purchased supplemental insurance (9%) or other (1%).

Forty percent of the patients were employed either full- or part-time, while 37% were retired and 15% were unemployed.

Half of the participants traveled more than 300 miles to receive their cancer care. The other half either traveled less than 100 miles (23%) for their cancer care or traveled 101 to 300 miles (27%).

Thirty percent of the participants were either fully (6%) or partially (24%) reimbursed for their travel.

Out-of-pocket, patients spent a median of $1,075 a month on non-medical expenses. Expenses attributed to medical costs accounted for $475 out-of-pocket per month. The survey demonstrated that more than half (55%) of patients felt that their expenses attributed to medical costs were higher than expected. Sixty-four percent of patients also reported that they felt their non-medical expenses were higher than expected.

Factors associated with a worse financial burden included an annual household income of less than $60,000, participating on at least one previous phase 1 clinical trial and living more than 100 miles away from the clinical trial site.

Huey concluded his presentation noting that the economic burden patients participating on clinical trials experience is high, and that most of the costs are related to nonmedical expenses.

Financial toxicity disproportionately affects patients with lower income and those who travel far to receive their care, he said. And costs are often higher than expected. Work needs to be done to ensure this financial toxicity is not a deterrent to enrollment. And sponsors and payers should consider the role of trial expense reimbursement.

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Out-of-Pocket Costs Often Higher Than Expected for Patients with Cancer Participating on Clinical Trials - Curetoday.com

Cancer Stem Cells (Cscs) Market Breaking new Grounds and touch new Level in Upcoming Year by Janssen, Qiagen, Advanced Cell Diagnostics, ApoCell,…

By Stem Cell Treatment

Cancer Stem Cells Marketresearch is an intelligence report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. Business strategies of the key players and the new entering market industries are studied in detail. Well explained SWOT analysis, revenue share and contact information are shared in this report analysis.

Cancer Stem Cells Market is growing at a High CAGR during the forecast period 2020-2026. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market.

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Top Key Players Profiled in This Report:

Janssen, Qiagen, Advanced Cell Diagnostics, ApoCell, Biofluidica, Clearbridge Biomedics, CytoTrack, Celsee, Fluxion, Gilupi, Cynvenio, On-chip, YZY Bio, BioView, Creatv MicroTech, Fluidigm, Ikonisys, AdnaGen, IVDiagnostics, Miltenyi Biotec, Aviva Biosciences Corporation, ScreenCell, Silicon Biosystems.

The key questions answered in this report:

Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Cancer Stem Cells market. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market. The influence of the latest government guidelines is also analyzed in detail in the report. It studies the Cancer Stem Cells markets trajectory between forecast periods.

Global Cancer Stem Cells Market Segmentation:

Market Segmentation: By Type

CellSearch Others

Market Segmentation: By Application

Breast Cancer Diagnosis and Treatment Prostate Cancer Diagnosis and Treatment Colorectal Cancer Diagnosis and Treatment Lung Cancer Diagnosis and Treatment Other Cancers Diagnosis and Treatment

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Table of Contents

Global Cancer Stem Cells Market Research Report 2020 2026

Chapter 1 Cancer Stem Cells Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Cancer Stem Cells Market Forecast

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Cancer Stem Cells (Cscs) Market Breaking new Grounds and touch new Level in Upcoming Year by Janssen, Qiagen, Advanced Cell Diagnostics, ApoCell,...

Stem Cell Therapy Market Key Opportunities & Development the COVID-19 – Kentucky Journal 24

By Stem Cell Medicine

Stem cells are most vital cells found in both humans and non-human animals. Stem cells are also known as centerpiece of regenerative medicine. Regenerative medicines have capability to grow new cells and replace damaged and dead cells. Stem cell is the precursors of all cells in the human body. It has the ability to replicate itself and repair and replace other damaged tissues in the human body. In addition, stem cell based therapies are used in the treatment of several chronic diseases such as cancer and blood disorders.

The global stem cell therapy market is categorized based on various modes of treatment and by therapeutic applications. The treatment segment is further sub-segmented into autologous stem cell therapy and allogeneic stem cell therapy. The application segment includes metabolic diseases, eye diseases, immune system diseases, musculoskeletal disorders, central nervous system disorders, cardiovascular diseases and wounds and injuries.

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Stem Cell Therapy Market, By Treatments:

Allogeneic Stem Cell Therapy Autologous Stem Cell Therapy

Stem Cell Therapy Market, By End Users:

Hospitals Ambulatory Surgical Centers

Stem Cell Therapy Market, By Application:

Oncology Central Nervous System Diseases Eye Diseases Musculoskeletal Diseases Wound & Injuries Metabolic Disorders Cardiovascular Disorders Immune System Disorders

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Stem Cell Therapy Market, By Geography:

North America Europe Asia Pacific Middle East & Africa Latin America

In terms of geographic, North America dominates the global stem cell therapy market due to increased research activities on stem cells. The U.S. represents the largest market for stem cell therapy followed by Canada in North America. However, Asia is expected to show high growth rates in the next five years in global stem cell therapy market due to increasing population. In addition, increasing government support by providing funds is also supporting in growth of the stem cell therapy market in Asia. China and India are expected to be the fastest growing stem cell therapy markets in Asia.

Key Players in the Stem Cell Therapy Market are:

Chiesi Farmaceutici S.P.A Are: Gamida Cell ReNeuron Group, plc Osiris Therapeutics, Inc. Stem Cells, Inc. Vericel Corporation. Mesoblast, Ltd.

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Stem Cell Therapy Market Key Opportunities & Development the COVID-19 - Kentucky Journal 24

Comprehensive Study on Regenerative Medicine Market 2020 | Trends, Drivers, Strategies, Applications and Competitive Landscape Forecast to 2024 – Cole…

By Stem Cell Medicine

Becton Dickinson and Company

Scope of the Report:

As per the , regenerative medicines are used to repair, replace, and regenerate the tissues and organs affected by injury, disease, or the natural aging process. These medicines restore the functionality of cells and tissues and are used in several degenerative disorders, such as dermatology, neurodegenerative diseases, cardiovascular, and orthopedic applications.

The Report Covers:

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Key Market Trends:

Dermatology is the Segment by Application that is Expected to be the Largest During the Forecast Period

Dermatology is estimated to have the largest share in revenue generation, and this high contribution is attributive to the presence of easy grafting techniques for dermatological wounds and diseases. Skin, being an organ with great cell replication characteristics, provides various types of stem cells from its different layers. Therefore, there are a broad range of products present, from patches to cure small injuries to matrix and grafts for chronic wounds and burns. Thus, the segment is expected to continue to dominate the market through to the forecast period.

The increasing number of accidents and bone defects is also expected to drive the regenerative medicine market. There are also several research studies that are being conducted on tissue engineering for the development of bone graft substitutes, with the help of regenerative medicine. So, with the new advances in bone graft, the market is expected to grow over the forecast period.

North America Holds the Largest Share and is Expected to Follow the Same Trend Over the Forecast Period

North America is estimated to have the largest share, in terms of revenue, owing to the presence of major players and rapid advances in technology, along with high investments in stem cell and oncology research. There is also an increasing prevalence of diseases, such as cancer and diabetes, which can now be cured by various stem cell therapies. Additionally, the awareness regarding the available stem cell procedures and therapies among people is rising, which in turn, is increasing the demand for the overall market.

Key Questions Answered in This Report:

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Detailed TOC of Regenerative Medicine Market 2019-2024:

1 INTRODUCTION 1.1 Study Deliverables 1.2 Study Assumptions 1.3 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS 4.1 Market Overview 4.2 Market Drivers 4.2.1 Increasing Adoption of Stem Cell Technology 4.2.2 Technological Advancements in Regenerative Medicine 4.3 Market Restraints 4.3.1 Regulatory and Ethical Issues 4.3.2 High Cost of Treatments 4.4 Porters Five Forces Analysis 4.4.1 Threat of New Entrants 4.4.2 Bargaining Power of Buyers/Consumers 4.4.3 Bargaining Power of Suppliers 4.4.4 Threat of Substitute Products 4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION 5.1 By Type of Technology 5.1.1 Stem Cell Therapy 5.1.2 Biomaterial 5.1.3 Tissue Engineering 5.1.4 Other Types of Technologies 5.2 By Application 5.2.1 Bone Graft Substitutes 5.2.2 Osteoarticular Diseases 5.2.3 Dermatology 5.2.4 Cardiovascular 5.2.5 Central Nervous System 5.2.6 Other Applications 5.3 Geography 5.3.1 North America 5.3.1.1 United States 5.3.1.2 Canada 5.3.1.3 Mexico 5.3.2 Europe 5.3.2.1 Germany 5.3.2.2 United Kingdom 5.3.2.3 France 5.3.2.4 Italy 5.3.2.5 Spain 5.3.2.6 Rest of Europe 5.3.3 Asia-Pacific 5.3.3.1 China 5.3.3.2 Japan 5.3.3.3 India 5.3.3.4 Australia 5.3.3.5 South Korea 5.3.3.6 Rest of Asia-Pacific 5.3.4 Middle East & Africa 5.3.4.1 GCC 5.3.4.2 South Africa 5.3.4.3 Rest of Middle East & Africa 5.3.5 South America 5.3.5.1 Brazil 5.3.5.2 Argentina 5.3.5.3 Rest of South America

6 COMPETITIVE LANDSCAPE 6.1 Company Profiles 6.1.1 Allergan 6.1.2 Osiris Therapeutics 6.1.3 Integra Lifesciences 6.1.4 Cook Biotech Incorporated 6.1.5 Organogenesis Inc. 6.1.6 Baxter 6.1.7 Medtronic 6.1.8 Thermo Fisher Scientific 6.1.9 Sigma-Aldrich Co. 6.1.10 Becton Dickinson and Company

7 MARKET OPPORTUNITIES AND FUTURE TRENDS

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Biobanks Market Research Report 2020-2024 | Analysis by Key Regions, Manufacturing Technology and Development Forecast Industry Research.co – 3rd…

By Stem Cell Medicine

VWR International LLC

Biobanks Market Report Highlights:

Scope of the Report:

As per the , biobank is a biorepository, where various biomaterials (usually human specimens) are stored for research purpose. This study targets gaining a detailed overview of the market dynamics of the contemporary biobank market during the forecast period. It focuses on the need to develop strategic insights into the global and country-level markets, taking into consideration the demand for services and equipment in biobanks. The growth of this market is largely fueled by the increasing applications, increasing investments in R&D, technological advancements, and growing demand in the developing countries (China and India) of Asia-Pacific.

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Key Market Trends:

Cryogenic Storage Segment by Equipment is Expected to Account for the Largest Market Share During the Forecast Period

In biobanks, the cryogenic storage systems are basically used to store different life sciences materials at a very low temperature. The low temperature storage increases the longevity of the cells, while at the same time reducing the intensity of freezing damage. Various cryogenic storage devices are available that have been designed to allow storage of both liquid and vapor phase materials. The temperature in the cryogenic storage system is required to be maintained continuously. Currently, all demand is for automated cryogenic storage devices. This segment is further divided into refrigerators, ice machines, and freezers. With advanced storage and automated devices propelling the growth of the market, steady growth in the North American and European markets is expected.

North America Accounted for the Largest Share in the Global Market

North America is holds a major share in the global biobanks market, and it is expected to show a similar trend over the forecast period, without significant fluctuations. The United States has the largest expenditure for R&D and better healthcare infrastructure in the world. Different pharmaceutical/ biotech companies, academia, and research institutes are utilizing biobanks for the storage of DNA, RNA, tissue, serum, blood, plasma, cells, etc. According to the Hastings Center, a non-profit organization, 300 million biospecimens have been stored in the United States in various public and private biobanks. The market is in demand for the most advanced automated systems, and there is also a high adoption rate for new technology.

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Detailed TOC of Biobanks Market Report 2019-2024:

1 INTRODUCTION 1.1 Study Deliverables 1.2 Study Assumptions 1.3 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS 4.1 Market Overview 4.2 Market Drivers 4.2.1 Innovations in Regenerative Medicine 4.2.2 Growing Incidences of Chronic Diseases 4.2.3 Advances in Drug Discovery and Development 4.2.4 R&D Funding and Investments by Government and Non-governmental Organizations 4.3 Market Restraints 4.3.1 Regulatory Issues 4.3.2 Cost Constraints 4.4 Porters Five Forces Analysis 4.4.1 Threat of New Entrants 4.4.2 Bargaining Power of Buyers/Consumers 4.4.3 Bargaining Power of Suppliers 4.4.4 Threat of Substitute Products 4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION 5.1 Equipment 5.1.1 Cryogenic Storage Systems 5.1.1.1 Refrigerators 5.1.1.2 Ice Machines 5.1.1.3 Freezers 5.1.2 Alarm Monitoring Systems 5.1.3 Other Equipment 5.2 Media 5.2.1 Optimized Media 5.2.2 Non-optimized Media 5.3 Services 5.3.1 Human Tissue Biobanking 5.3.2 Stem Cell Biobanking 5.3.3 Cord Banking 5.3.4 DNA/RNA Biobanking 5.3.5 Other Services 5.4 Application 5.4.1 Regenerative Medicine 5.4.2 Drug Discovery 5.4.3 Disease Research 5.5 Geography 5.5.1 North America 5.5.1.1 United States 5.5.1.2 Canada 5.5.1.3 Mexico 5.5.2 Europe 5.5.2.1 Germany 5.5.2.2 United Kingdom 5.5.2.3 France 5.5.2.4 Italy 5.5.2.5 Spain 5.5.2.6 Rest of Europe 5.5.3 Asia-Pacific 5.5.3.1 China 5.5.3.2 Japan 5.5.3.3 India 5.5.3.4 Australia 5.5.3.5 South Korea 5.5.3.6 Rest of Asia-Pacific 5.5.4 Middle East & Africa 5.5.4.1 GCC 5.5.4.2 South Africa 5.5.4.3 Rest of Middle East & Africa 5.5.5 South America 5.5.5.1 Brazil 5.5.5.2 Argentina 5.5.5.3 Rest of South America

6 COMPETITIVE LANDSCAPE 6.1 Company Profiles 6.1.1 Atlanta Biologicals Inc. 6.1.2 Becton, Dickinson and Company 6.1.3 BioLifeSolutions Inc. 6.1.4 Chart Industries Inc. 6.1.5 Hamilton Company 6.1.6 Qiagen NV 6.1.7 Sigma-Aldrich Inc. (Merck KGaA) 6.1.8 STEMCELL Technologies Inc. 6.1.9 Thermo Fisher Scientific Inc. 6.1.10 VWR International LLC

7 MARKET OPPORTUNITIES AND FUTURE TRENDS

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Biobanks Market Research Report 2020-2024 | Analysis by Key Regions, Manufacturing Technology and Development Forecast Industry Research.co - 3rd...

Autologous Stem Cell & Non-Stem Cell Based Therapies Market Research Report – Global Forecast to 2025 – Cumulative Impact of COVID-19 – Yahoo…

By Stell Cell Research

Autologous Stem Cell & Non-Stem Cell Based Therapies Market Research Report - Global Forecast to 2025 - Cumulative Impact of COVID-19 The Global Autologous Stem Cell & Non-Stem Cell Based Therapies Market is expected to grow from USD 4,207.

New York, July 16, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Autologous Stem Cell & Non-Stem Cell Based Therapies Market Research Report - Global Forecast to 2025 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p05913303/?utm_source=GNW 55 Million in 2019 to USD 9,109.64 Million by the end of 2025 at a Compound Annual Growth Rate (CAGR) of 13.73%.

Market Segmentation & Coverage: This research report categorizes the Autologous Stem Cell & Non-Stem Cell Based Therapies to forecast the revenues and analyze the trends in each of the following sub-markets:

On the basis of Geography, the Autologous Stem Cell & Non-Stem Cell Based Therapies Market is studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas region is studied across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific region is studied across Australia, China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa region is studied across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Company Usability Profiles: The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Autologous Stem Cell & Non-Stem Cell Based Therapies Market including Antria, Bioheart, Brainstorm Cell Therapeutics, Cytori, Dendreon Corporation, Fibrocell, Genesis Biopharma, Georgia Health Sciences University, Neostem, Opexa Therapeutics, Orgenesis, Regeneus, Regenexx, and Tengion.

FPNV Positioning Matrix: The FPNV Positioning Matrix evaluates and categorizes the vendors in the Autologous Stem Cell & Non-Stem Cell Based Therapies Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Competitive Strategic Window: The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth.

Cumulative Impact of COVID-19: COVID-19 is an incomparable global public health emergency that has affected almost every industry, so for and, the long-term effects projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlaying COVID-19 issues and potential paths forward. The report is delivering insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecast, considering the COVID-19 impact on the market.

The report provides insights on the following pointers: 1. Market Penetration: Provides comprehensive information on sulfuric acid offered by the key players 2. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets 3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments 4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players 5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments

The report answers questions such as: 1. What is the market size and forecast of the Global Autologous Stem Cell & Non-Stem Cell Based Therapies Market? 2. What are the inhibiting factors and impact of COVID-19 shaping the Global Autologous Stem Cell & Non-Stem Cell Based Therapies Market during the forecast period? 3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Autologous Stem Cell & Non-Stem Cell Based Therapies Market? 4. What is the competitive strategic window for opportunities in the Global Autologous Stem Cell & Non-Stem Cell Based Therapies Market? 5. What are the technology trends and regulatory frameworks in the Global Autologous Stem Cell & Non-Stem Cell Based Therapies Market? 6. What are the modes and strategic moves considered suitable for entering the Global Autologous Stem Cell & Non-Stem Cell Based Therapies Market? Read the full report: https://www.reportlinker.com/p05913303/?utm_source=GNW

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Autologous Stem Cell & Non-Stem Cell Based Therapies Market Research Report - Global Forecast to 2025 - Cumulative Impact of COVID-19 - Yahoo...

Stem Cell Cartilage Regeneration Market Size, Share, Growth-Trends, Emerging-Technologies, Software-Platforms, 2020 Global Development,…

By Stell Cell Research

arcognizance.com has added latest research report on Global Stem Cell Cartilage Regeneration Market, this report helps to analyze top manufacturers, regions, revenue, price, and also covers Industry sales channel, distributors, traders, dealers, research findings, conclusion, appendix and data source.

HNY Research projects that the Stem Cell Cartilage Regeneration market size will grow from XXX in 2019 to XXX by 2025, at an estimated CAGR of XX. The base year considered for the study is 2019, and the market size is projected from 2020 to 2025.

Download PDF Sample of Stem Cell Cartilage Regeneration Market report @ https://www.arcognizance.com/enquiry-sample/998763

By Market Players: Anika Therapeutics, Zimmer Biomet, BioTissue Technologies, DePuy (Johnson & Johnson), Genzyme, CellGenix, EMD Serono, Sanofi Aventis, Smith & Nephew

By Application Hyaline Cartilage, Fibrocartilage, Other

By Type Cell Based Approaches, Non-cell Based Approaches

The prime objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing. Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts. The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

Brief about Stem Cell Cartilage Regeneration Market Report with TOC @ https://www.arcognizance.com/report/2020-2025-global-and-regional-stem-cell-cartilage-regeneration-industry-production-sales-and-consumption-status-and-prospects-professional-market-research-report

Points Covered in The Report: The points that are discussed within the report are the major market players that are involved in the market such as manufacturers, raw material suppliers, equipment suppliers, end users, traders, distributors and etc. The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. The historical data from 2014 to 2019 and forecast data from 2020 to 2025. The growth factors of the market is discussed in detail wherein the different end users of the market are explained in detail. Data and information by manufacturer, by region, by type, by application and etc, and custom research can be added according to specific requirements. The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.

Key Reasons to Purchase To gain insightful analyses of the market and have comprehensive understanding of the global market and its commercial landscape. Assess the production processes, major issues, and solutions to mitigate the development risk. To understand the most affecting driving and restraining forces in the market and its impact in the global market. Learn about the market strategies that are being adopted by leading respective organizations. To understand the future outlook and prospects for the market. Besides the standard structure reports, we also provide custom research according to specific requirements.

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Table of Content

Chapter One: Industry Overview

Chapter Two: Major Segmentation (Classification, Application and etc.) Analysis

Chapter Three: Production Market Analysis

Chapter Four: Sales Market Analysis

Chapter Five: Consumption Market Analysis

Chapter Six: Production, Sales and Consumption Market Comparison Analysis

Chapter Seven: Major Manufacturers Production and Sales Market Comparison Analysis

Chapter Eight: Competition Analysis by Players

Chapter Nine: Marketing Channel Analysis

Chapter Ten: New Project Investment Feasibility Analysis

Chapter Eleven: Manufacturing Cost Analysis

Chapter Twelve: Industrial Chain, Sourcing Strategy and Downstream Buyers

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List of Table and Figure

Figure Product Picture Table 2014-2019 Major Types Market Sales Volume And Market Share Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Figure 2014-2019 Sales Volume And Growth Rate Table 2014-2019 Capacity, Production, Capacity Utilization Rate, Ex-Factory Price, Revenue, Cost, Gross And Gross Margin Figure 2014-2019 Capacity, Production And Growth Rate Figure 2014-2019 Capacity, Production And Capacity Utilization Rate continued

Note:

Due to the ongoing COVID-19 pandemic around the world, the figures in the report study represented in the study might differ along with production capacities and other mentioned aspects. Also, note that there is a possibility of a cooldown period after the pandemic that the data might differ as the world economy aims to catch on.

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Flow Cytometry Market Report Extensive Analysis 2020 | Specified by Production, Technology, Competition, and Revenue Forecast till 2024 – 3rd Watch…

By Stell Cell Research

Agilent Technologies

Scope of the Report:

Flow cytometry is a laser or an impedance-based technology, which is used in cell counting, detecting biomarker, cell sorting, and protein engineering, by suspending the cell in a stream of fluid and then passing them through a detection apparatus. It is the ideal tool to identify, characterize, and isolate stem and progenitor cells, for research and potential clinical use.

The Report Covers:

For More Information or Query or Customization Before Buying, Visit at https://www.industryresearch.co/enquiry/pre-order-enquiry/13999638

Key Market Trends:

Stem Cell Therapy is Expected to Hold the Largest Market Share, by Application

The stem cell therapy segment is believed to have the largest market size and is expected to witness a CAGR of 8.4% during the forecast period.

The key reasons for the large market share include the extensive use of flow cytometry for effective diagnosis and early detection of numerous diseases that have helped the market to gain immense shares. There has been a growing market penetration in stem cell research, adoption of recombinant DNA technology for antibody production, and the evolution of tandem flow cytometry technologies that are expected to offer growth opportunities for the players operating in the flow cytometry market during the forecast period.

Though flow cytometry has also found many applications in several stages of drug discovery, its routine widespread use for high throughput drug screening has been limited. This is unlike analogous technology, automated high content imaging (HCI), which, in terms of drug screening, is an established technology that is common in screening laboratories.

North America Dominates the Market and is Expected to Continue its Lead over the Forecast Period

North America holds a major share of the flow cytometry market and is projected to continue over the next few years. An increasing prevalence of diseases and the rising contribution from the US market are expected to help the market grow. In addition, there has also been a rise in the expansion of novel products that are anticipated to offer new growth opportunities in the coming years.

Key Questions Answered in This Report:

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Detailed TOC of Flow Cytometry Market 2019-2024:

1 INTRODUCTION 1.1 Study Deliverables 1.2 Study Assumptions 1.3 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS 4.1 Market Overview 4.2 Market Drivers 4.2.1 Use of Flow Cytometry in Stem Cell Research 4.2.2 Emergence and Commercial Applications of New Technologies in the Field of Flow Cytometry 4.2.3 Increasing Applications of Flow Cytometry in Clinical Research 4.3 Market Restraints 4.3.1 Lack of Awareness about the Potential Benefits of Flow Cytometry Techniques 4.3.2 Expensive Equipment 4.4 Industry Attractiveness Porters Five Forces Analysis 4.4.1 Threat of New Entrants 4.4.2 Bargaining Power of Buyers/Consumers 4.4.3 Bargaining Power of Suppliers 4.4.4 Threat of Substitute Products 4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION 5.1 Product Type 5.1.1 Instrument 5.1.2 Fluorophore 5.1.3 Kit and Reagent 5.1.4 Software 5.1.5 Other Product Types 5.2 Technology 5.2.1 Cell-based Flow Cytometry 5.2.2 Bead-based Flow Cytometry 5.3 Application 5.3.1 Oncology 5.3.2 Drug Discovery 5.3.3 Disease Diagnosis 5.3.4 Stem Cell Therapy 5.3.5 Organ Transplantation 5.3.6 Hematology 5.3.7 Other Applications 5.4 By End User 5.4.1 Hospitals and Clinics 5.4.2 Academia and Research Institutes 5.4.3 Pharmaceutical and Biotechnology Companies 5.4.4 Other End Users 5.5 Geography 5.5.1 North America 5.5.1.1 US 5.5.1.2 Canada 5.5.1.3 Mexico 5.5.2 Europe 5.5.2.1 Germany 5.5.2.2 UK 5.5.2.3 France 5.5.2.4 Italy 5.5.2.5 Spain 5.5.2.6 Rest of Europe 5.5.3 Asia-Pacific 5.5.3.1 China 5.5.3.2 Japan 5.5.3.3 India 5.5.3.4 Australia 5.5.3.5 South Korea 5.5.3.6 Rest of Asia-Pacific 5.5.4 Middle East & Africa 5.5.4.1 GCC 5.5.4.2 South Africa 5.5.4.3 Rest of Middle East & Africa 5.5.5 South America 5.5.5.1 Brazil 5.5.5.2 Argentina 5.5.5.3 Rest of South America

6 COMPETITIVE LANDSCAPE 6.1 Company Profiles 6.1.1 Becton, Dickinson and Company 6.1.2 Beckman Coulter 6.1.3 EMD Millipore (Merck KGaA) 6.1.4 Bio-Rad Laboratories 6.1.5 Luminex Corporation 6.1.6 Life Technologies 6.1.7 Miltenyi Biotech 6.1.8 Sysmex Partec GmbH 6.1.9 Agilent Technologies

7 MARKET OPPORTUNITIES AND FUTURE TRENDS

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Flow Cytometry Market Report Extensive Analysis 2020 | Specified by Production, Technology, Competition, and Revenue Forecast till 2024 - 3rd Watch...

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