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Fate Therapeutics Announces FDA Clearance of IND Application for First-ever iPSC-derived CAR T-Cell Therapy | 2020-07-09 | Press Releases – Stockhouse

By adminJuly 10, 2020Induced Pluripotent Stem Cells

FT819 CAR T-cell Product Candidate Derived from Clonal Master iPSC Line with Novel CD19-specific 1XX CAR Integrated into TRAC Locus

Phase 1 Clinical Study will Evaluate FT819 for Patients with Advanced B-cell Leukemias and Lymphomas

SAN DIEGO, July 09, 2020 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for cancer and immune disorders, announced today that the U.S. Food and Drug Administration (FDA) has cleared the Company’s Investigational New Drug (IND) application for FT819, an off-the-shelf allogeneic chimeric antigen receptor (CAR) T-cell therapy targeting CD19+ malignancies. FT819 is the first-ever CAR T-cell therapy derived from a clonal master induced pluripotent stem cell (iPSC) line, and is engineered with several first-of-kind features designed to improve the safety and efficacy of CAR T-cell therapy. The Company plans to initiate clinical investigation of FT819 for the treatment of patients with relapsed / refractory B-cell malignancies, including chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), and non-Hodgkin lymphoma (NHL).

The clearance of our IND application for FT819 is a ground-breaking milestone in the field of cell-based cancer immunotherapy. Our unique ability to produce CAR T cells from a clonal master engineered iPSC line creates a pathway for more patients to gain timely access to therapies with curative potential,” said Scott Wolchko, President and Chief Executive Officer of Fate Therapeutics. Four years ago, we first set out under our partnership with Memorial Sloan Kettering led by Dr. Michel Sadelain to improve on the revolutionary success of patient-derived CAR T-cell therapy and bring an off-the-shelf paradigm to patients, and we are very excited to advance FT819 into clinical development.”

FT819 was designed to specifically address several limitations associated with the current generation of patient- and donor-derived CAR T-cell therapies. Under a collaboration with Memorial Sloan Kettering Cancer Center (MSK) led by Michel Sadelain, M.D., Ph.D., Director, Center for Cell Engineering, and Head, Gene Expression and Gene Transfer Laboratory at MSK, the Company incorporated several first-of-kind features into FT819 including:

The multi-center Phase 1 clinical trial of FT819 is designed to determine the maximum tolerated dose of FT819 and assess its safety and clinical activity in up to 297 adult patients across three types of B-cell malignancies (CLL, ALL, and NHL). Each indication will enroll independently and evaluate three dose-escalating treatment regimens: Regimen A as a single dose of FT819; Regimen B as a single dose of FT819 with IL-2 cytokine support; and Regimen C as three fractionated doses of FT819. For each indication and regimen, dose-expansion cohorts of up to 15 patients may be enrolled to further evaluate the clinical activity of FT819.

At the American Association for Cancer Research (AACR) Virtual 2020 Meeting, the Company presented preclinical data demonstrating FT819 is comprised of CD8a T cells with uniform 1XX CAR expression and complete elimination of endogenous TCR expression. Additionally, data from functional assessments showed FT819 has antigen-specific cytolytic activity in vitro against CD19-expressing leukemia and lymphoma cell lines that is comparable to that of healthy donor-derived CAR T cells, and persists and maintains tumor clearance in the bone marrow in an in vivo disseminated xenograft model of lymphoblastic leukemia.

Fate Therapeutics has an exclusive license for all human therapeutic use to U.S. Patent No. 10,370,452 pursuant to its license agreement with MSK1, which patent covers compositions and uses of effector T cells expressing a CAR, where such T cells are derived from a pluripotent stem cell including an iPSC. In addition to the patent rights licensed from MSK, the Company owns an extensive intellectual property portfolio that broadly covers compositions and methods for the genome editing of iPSCs using CRISPR and other nucleases, including the use of CRISPR to insert a CAR in the TRAC locus for endogenous transcriptional control.

1 Fate Therapeutics has licensed intellectual property from MSK on which Dr. Sadelain is an inventor. As a result of the licensing arrangement, MSK has financial interests related to Fate Therapeutics.

About Fate Therapeutics’ iPSC Product Platform The Company’s proprietary induced pluripotent stem cell (iPSC) product platform enables mass production of off-the-shelf, engineered, homogeneous cell products that can be administered with multiple doses to deliver more effective pharmacologic activity, including in combination with cycles of other cancer treatments. Human iPSCs possess the unique dual properties of unlimited self-renewal and differentiation potential into all cell types of the body. The Company’s first-of-kind approach involves engineering human iPSCs in a one-time genetic modification event and selecting a single engineered iPSC for maintenance as a clonal master iPSC line. Analogous to master cell lines used to manufacture biopharmaceutical drug products such as monoclonal antibodies, clonal master iPSC lines are a renewable source for manufacturing cell therapy products which are well-defined and uniform in composition, can be mass produced at significant scale in a cost-effective manner, and can be delivered off-the-shelf for patient treatment. As a result, the Company’s platform is uniquely capable of overcoming numerous limitations associated with the production of cell therapies using patient- or donor-sourced cells, which is logistically complex and expensive and is subject to batch-to-batch and cell-to-cell variability that can affect clinical safety and efficacy. Fate Therapeutics’ iPSC product platform is supported by an intellectual property portfolio of over 300 issued patents and 150 pending patent applications.

About Fate Therapeutics, Inc. Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for cancer and immune disorders. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Company’s immuno-oncology product candidates include natural killer (NK) cell and T-cell cancer immunotherapies, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens with chimeric antigen receptors (CARs). The Company’s immuno-regulatory product candidates include ProTmune, a pharmacologically modulated, donor cell graft that is currently being evaluated in a Phase 2 clinical trial for the prevention of graft-versus-host disease, and a myeloid-derived suppressor cell immunotherapy for promoting immune tolerance in patients with immune disorders. Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit http://www.fatetherapeutics.com.

Forward-Looking Statements This release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 including statements regarding the advancement of and plans related to the Company's product candidates and clinical studies, the Company’s progress, plans and timelines for the clinical investigation of its product candidates, the therapeutic potential of the Company’s product candidates including FT819, and the Company’s clinical development strategy for FT819. These and any other forward-looking statements in this release are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk of difficulties or delay in the initiation of any planned clinical studies, or in the enrollment or evaluation of subjects in any ongoing or future clinical studies, the risk that the Company may cease or delay preclinical or clinical development of any of its product candidates for a variety of reasons (including requirements that may be imposed by regulatory authorities on the initiation or conduct of clinical trials or to support regulatory approval, difficulties in manufacturing or supplying the Company’s product candidates for clinical testing, and any adverse events or other negative results that may be observed during preclinical or clinical development), the risk that results observed in preclinical studies of FT819 may not be replicated in ongoing or future clinical trials or studies, and the risk that FT819 may not produce therapeutic benefits or may cause other unanticipated adverse effects. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the Company’s actual results to differ from those contained in the forward-looking statements, see the risks and uncertainties detailed in the Company’s periodic filings with the Securities and Exchange Commission, including but not limited to the Company’s most recently filed periodic report, and from time to time in the Company’s press releases and other investor communications. Fate Therapeutics is providing the information in this release as of this date and does not undertake any obligation to update any forward-looking statements contained in this release as a result of new information, future events or otherwise.

Contact: Christina Tartaglia Stern Investor Relations, Inc. 212.362.1200 christina@sternir.com

Original post:
Fate Therapeutics Announces FDA Clearance of IND Application for First-ever iPSC-derived CAR T-Cell Therapy | 2020-07-09 | Press Releases - Stockhouse

Coronavirus updates: California to release 8,000 inmates; masks ‘only way’ to prevent another shutdown, Texas Gov. says – USA TODAY

By adminJuly 10, 2020Stem Cell Medical Center

If you thought COVID-19 symptoms couldn't get worse, doctors say a new symptom has emerged. Hallucinations. USA TODAY

A spiking COVID-19 case countis straining Florida's hospital system as nearly half of its intensive care units are at least 90% full, state data shows.

On Thursday, Florida recorded aone-day record of 120 deaths. More than 4,000 people have died there since the start of the pandemic.

Mississippi has also seen a recent strain on its hospitals. Five of the largest medical centers have no ICU bed space for new patients COVID-19 or otherwise and are being forced to turn patients away.

Meanwhile, some states are scaling back reopening guidelines or adding new requirements: Some bars in Nevada will be closing again Friday and restaurants can no longer serve parties more than six people.Kentucky will join the growing list of states that require face coverings in public, too.

In New Mexico, indoor dining at restaurants and breweries will be restricted again starting Monday, and Gov. Michelle Lujan Grisham halted high school sports and said state parks will be closed to out-of-state residents.

Here are some recent developments:

Today's stats:The U.S. has surpassed 3.1 million confirmed cases of COVID-19, the disease caused by the novel coronavirus. More than133,000deaths have been confirmed, according toJohn Hopkins University data. Globally, there have been 12.3 million cases and over 556,000deaths.

What we're reading:ThreeArizona teachers shared a classroom for summer school.They thought they were being "very careful."All threecontracted COVID-19, and one died.The teachers who survived say their colleague's death is a stark reminder of the risks teachers will face if school reopens too soon.

Our live blog will be updated throughout the day. For first-in-the-morning updates,sign upfor The Daily Briefing.

R-0 may be the most important scientific term youve never heard of when it comes to stopping the coronavirus pandemic. USA TODAY

Schools should prioritize safety and rely on local authorities inschool reopening plans, ajoint statementfrom associations of pediatricians, educators and superintendents says.

"Returning to school is important for the healthy development and well-being of children, but we must pursue re-opening in a way that is safe for all students, teachers and staff," the statement says. "Science should drive decision-making on safely reopening schools."

The statement follows a push fromTrump to open schools across the nation andamid a nationwide debate over whether children should return to the classroom.

The statement says the organizations The American Academy of Pediatrics, American Federation of Teachers, the National Education AssociationandThe School Superintendents Association favor a localized approach driven by re experts over a "one-size-fits-all" approach.

In an effort to prevent the spread of COVID-19 in Californiastate prisons, upto 8,000 currently incarcerated people could be released by the end of August, the state's Department of Corrections and Rehabilitation announced Friday.

"Too many people are incarcerated for too long in facilities that spread poor health. Supporting the health and safety of all Californians means releasing people unnecessarily incarcerated and transforming our justice system,"Jay Jordan, Executive Director ofCalifornians for Safety and Justice, said in a press release.

Since the start of the pandemic, the state has releasedabout 10,000 people, according to the state'sDepartment of Corrections.

Activists have repeatedly called on the governor to address the outbreak atSan Quentin prison, where more than 200 staff and more than 1,300 prisoners have active cases, and at least six inmates have died, according to local news reports.

Amid a resurgence of COVID-19 in Georgia, Gov. Brian Kemp announced Friday that the state will reactivate its makeshift coronavirus hospital at a convention center in Atlanta.

The 200-bed temporary hospital at theGeorgia World Congress Centerwas constructed in April but wound down operations at the end of May.

Nearly 3,000 people have died and more than 111,000 people have tested positive for the virus in the state.

At least 47 students at UC Berkeley tested positive for the coronavirus in just one week, and most of the new cases stem from a series of Greek life parties, university officials said.

In a message to the campus community, UniversityHealth Services Medical Director Anna Harte and Assistant Vice Chancellor Guy Nicolette said it was "becoming harder to imagine bringing our campus community back in the way we are envisioning."

"Generally, these infections are directly related to social events where students have not followed basic safety measures such as physical distancing, wearing face coverings, limiting event size, and gathering outside," the officials wrote.

Texas Gov. Greg Abbott begged Texans to mask up in a Friday interview with eastern Texas TV station CBS19, saying face coverings were "the only way"businesses could stay open.

"Its disappointing"that some local officials are refusing to enforce the states mask order, Abbott said. "If we do not all join together and unite in this one cause for a short period of time it will lead to the necessity of having to close Texas back down."

Abbott's ordereffective July 3 requires face masksin public spaces in counties with 20 or more active COVID-19 cases.The order does not apply to people eating,drinking, swimming orexercising or those under 10 years old.

Joel Shannon

West Virginia is among states with the fewest COVID-19 cases, but the state now has the highest coronavirus transmission rate in the country, the head of the state's coronavirus response said Friday.

"The virus is spreading faster person to person in West Virginia right now than in any other state in the country,"Dr. Clay Marsh.The state's "RT value" the average number of people who become infected by an infectious personis the highest in the nation, at 1.37, Marsh said. "We can see that COVID is starting in that logarithmic phase, that compounding phase."

The state has doubled its number of active cases in the last 10-14 days.

Gov. Gretchen Whitmer on Friday expanded Michigan's mask-wearing requirements, effective Monday, saying that wearing masks is the best way to reverse an increase in coronavirus cases.

The order requires the use of face coverings in crowded outdoor spaces and reiterates that individuals are required to wear a face covering whenever they are in an indoor public space. The mandate also requires any business that is open to the public to refuse entry or service to people who refuse to wear a face covering, with limited exceptions.

Paul Egan, Detroit Free Press

Shutting down states in the early days of the US COVID-19 outbreak prevented at least 250,000 deaths and as many as 750,000-840,000 hospitalizations, a new study found. Shelter-in-place orders took about two weeks to show an effect on hospitalizations and three weeks to limit the number of deaths, according to the study by researchers at the University of Iowa and National Bureau of Economic Research.

The authors, who published their results in the journal Health Affairs, also found that deaths from causes other than COVID-19 might have increased if hospitals had become overwhelmed; slowing cases saved those lives, as well, they said.

"These estimates indicate that [stay in place orders] played a key role in flattening the curves not only for cases, but also for deaths and hospitalizations, and eased pressure on hospitals from avoided COVID-19 admissions," the authors conclude.

Karen Weintraub

All 50 states had visitors from Floridathis week, according to data that 15 million U.S. mobile device users provided to the data company Cuebiq. Applying Cuebiqs sample to the whole population, approximately 1.5 million Floridians are now setting up shop in other states.

Residents have left the state in increasing numbers at a time when the crisis there got worse. In early June, just 5% of the states residents appeared in other states. That number has ticked up every week.

Cuebiqs data, which is based on cell phone locations, shows that most interstate visitors from Florida appeared in other parts of the South. About 38% of the states travelers were in Georgia at least once during the week, for example. Alabama, North Carolina, South Carolina and Tennessee also topped the list of destinations for visitors from the hard-struck state.

States outside the region saw big Florida influxes as well. New York, Texas, Pennsylvania and Ohio all had more than 50,000 visits from Florida residents in the most recent week of data, based on an extrapolation of the cell phone location data.

Matt Wynn

New data on the experimental drug remdesivir confirms it can shorten the course of COVID-19 infections and suggests it also can save lives.

Gilead Sciences, Inc., a California pharmaceutical company that makes the drug, revealed data Friday about nearly 400 patients in its late-stage clinical trial.

According to the results, 74% of patients treated with remdesivir had recovered by their 14th day of hospitalization, compared to 59% of those who did not get the drug. Nearly 8% of the patients on remdesivir had died by day 14, versus more than 12% of patients who did not receive it.

The study also found patients who took the drug hydroxychloroquine along with remdesivir fared worse than those on remdesivir alone. The company recommended against using the drugs in combination.

Remdesivir, an antiviral initially developed to treat Ebola, has not yet been approved for widespread use by the U.S. Food and Drug Administration, but it has been given emergency use authorization to treat COVID-19 patients.

Karen Weintraub

Congestion, runny nose, nausea and diarrhea are the four most recent COVID-19 symptoms that the Centers for Disease Control and Prevention added to its growing list of potential signs of the novel coronavirus.

The CDC previously said symptoms include chills, fever, muscle pain, headache, sore throat and a new loss of taste or smell. The agency now lists 11 symptoms on its website.

The additions come as health experts continue to learn more about the disease, and care for very ill COVID-19 patients is improving. Even so, the CDC states the current list doesn't include all possible symptoms for the virus.

Wyatte Grantham-Philips

Fifty-eight Major League Baseball players tested positive for the coronavirus upon reporting to their team, while an additional 13 tested positive after workouts began, according to data released by MLB on Friday.

Perhaps most disconcerting is that 10 teams reported positive test results during what MLB is calling "monitoring testing," meaning one-third of the league's teams had an infected player or staff member after workouts began last week.

Several teams have had workouts halted or curtailed while awaiting test results, and besides those testing positive, players who have come in contact with those testing positive have been temporarily sidelined, as well.

Gabe Lacques

As COVID-19 cases spikeacross, multiple states have taken measures to scale back their reopening plans. Here are some of the last moves:

Read more about states that arepause reopening or take new steps to slow the spread.

A Los Angeles Times report says that researchers are working on an upper-arm injection that would deliverantibody-rich blood plasma of COVID-19 survivors to provide potentially months of protection from the virus.

The approach is similar to one used for other diseases likehepatitis A and could be widely available across the United States, the Times reported.

However, the proposal has received push back from the federal government and pharmaceutical companies, who argue efforts in plasma-based therapy should focus on treating sick people rather than preventing infection, the Times report says.

Dr. Anthony Fauci told the newspaper that the research was promising but more work is needed to show thatcoronavirus antibodies work.

Dr. Anthony Fauci, the nation's top infectious disease expert, said Friday he has not briefed President Donald Trump in at least two months and not seen him in person at the White House since June 2, despite a coronavirus resurgence that has strained hospitals and led several states to pause reopenings.

Fauci told the Financial Times he was "sure" his messages were sent to the president even though the two have not been in close contact in the past several weeks.

The comments from the Trump administration's director of the National Institute of Allergy and Infectious Diseases came as Trump has been critical of Fauci and spoken openly about issues on which they disagree.

In a Thursday interview with Fox News' Sean Hannity, Trump said Fauci had "made a lot of mistakes" but called him a "nice man." Trump also said "most cases" of coronavirus would "automatically cure. They automatically get better."

Fauci also in the FT interview said Trump was incorrect in claiming 99% of coronavirus cases were "harmless" and may have conflated some statistics.

Nicholas Wu

COVID survivors' main symptoms can linger for weeks or even months, causing pain, trouble breathing, nightmares and even organ failure. USA TODAY

Two scientists from the World Health Organization are traveling toBeijing on Friday to lay the groundwork for an investigation into the origins of the new coronavirus.

The researchers,an animal health expert and an epidemiologist, will work with counterparts in China to "look at whether or not it jumped from species to humanand what species it jumped from," WHO spokesperson Dr. Margaret Harris said.

The team will determine the logistics, locations and participantsfor a WHO-led international mission.

The virus was first detected in the central Chinese city of Wuhan late last year. Scientists believe the novel virusoriginated in bats, transferred to another mammal then jumpedto humans.

The Trump administration this week officially began withdrawing the United Statesfrom the WHO, of which President Donald Trump and his advisers have been sharply critical.

Americans are three times as likely to know someone in their community who has been sick with the coronavirus than they did in March, according to a new survey.

More than one-third of Americans (36%) say someone they know outside of their immediate family or work has been sick with the coronavirus, according to a new survey from the Democracy Fund + UCLA Nationscape Project. That number is more than triple the number in mid-March, when it was 11%.

The survey also showed Black (11%) and Latino (11%) Americans are more likely than white Americans (7%) to have had an immediate family member get sick, according to the survey. These racial differences were not apparent in the survey from March.

Rebecca Morin

Nearly half of Florida's intensive-care units are at least 90% full, and more than 1 in 5 are completely full, according to state data.

Hospitals are increasingly strained under COVID-19, andhospitalizations across the state have jumped more than 13% just since July 1. More than 17,100 Floridians have been hospitalized for COVID-19 since the start of the pandemic.

A total of 95 hospital ICUs were at least 90% full Thursday, according to the Florida Agency for Health Care Administration. That's nearly half the 207 ICUs that the agency is tracking. At least 45 hospital ICUs were at capacity, and 46 others had only one bed available in the units.

At least 4,111 people in Florida have died from the virus, according to the state a figure that would have made it the ninth leading cause of death in Florida last year, according to Florida Department of Health statistics. Florida set a one-day record Thursday with 120 deaths. The previous high, 83, was in late April.

Frank Gluck, Fort Myers News-Press

The five largest medical centers in Mississippi have no ICU bed space for new patients coronavirus or otherwise and are being forced to turn patients away, even as COVID-19 continue to surge.

In some cases, patients are being sent to facilities out of state and as far away as New Orleans. In many hospitals, patients admitted to the ER are being forced to spend the night before they receive treatment.

"(Wednesday), five of our biggest hospitals in the state had zero ICU beds. Zero," State Health Officer Dr. Thomas Dobbs said. "Our biggest medical institutions who take care of our sickest patients have no room."

The transition from shelter-in-place to where we currently stand, with the highest number of hospitalizations since the first reported case of the coronavirus virus on March 11, has left the state "wide open," said Dr. Louann Woodward, UMMC vice chancellor for health affairs.

Justin Vicory, Mississippi Clarion Ledger

California is set to become the first state to file a lawsuit against the Trump administration over anew policy that prevents international students from staying in the U.S. if their college or university switches to online-only classes in the fall because of the coronavirus pandemic.

The announcement comes a day after some colleges and universities filed similar lawsuits or announced plans to do so.

The Trump administration revealed its new guidelines in a memo issued by Immigration and Customs Enforcement on Monday. It says that international students will have to leave the country, or face possible deportation, if their schools switch to remote learning, which many have planned to do amid the pandemic.

President Donald Trumps attack on his own health experts guidance for safely reopening schools cracked open for public display a power strugglewithin the administration that has been building for months.

Trump blasted the guidance issued by the Centers for Disease Control and Prevention on Wednesday as very tough & expensive and asking schools to do very impractical things.

But CDC Director Dr. Robert Redfield said on Thursday the guidance would stand, and his staff would provide some new documents to clarify the recommendations.

Theflare-up punctuates a conflict escalating for months, with the nations top scientists publicly sidelined in the Trump administrations initial coronavirus response. Earlier disagreements delayed the release of the reopening guidance for schools and businesses.

Public health leaders who worked at the CDC under prior presidents said they had never seen anything like this weeks open discord."It underminesleadership for everyone involved, said Dr.JeffreyKoplan, a former CDC director."It's public health malpractice to say, 'Open without worrying about anything.'"

Brett Murphy and Letitia Stein

What's actually in the CDC school guidelines?These are the highlights.

Stem Cell Cartilage Regeneration Market | Global Industry Analysis By Trends, Size, Share, Company Overview, Growth And Forecast By 2026 – Sports…

By adminJuly 10, 2020Stell Cell Research

Stem Cell Cartilage Regeneration Market

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Cancer Stem Cell Therapeutics Market Provides in-depth analysis of the Cancer Stem Cell Therapeutics Industry, with current trends and future…

By adminJuly 10, 2020Stell Cell Research

The Cancer Stem Cell Therapeutics market report by Reports and Data provides an extensive overview of the vital elements of the Cancer Stem Cell Therapeutics market and factors such as drivers, restraints, latest trends, regulatory scenario, competitive landscape, technological advancements, and others. An in-depth analysis of these factors is offered to understand the future growth prospects of the global Cancer Stem Cell Therapeutics market.

Cancer Stem Cell Therapeutics Market Size USD 8463.9 Million in 2020, Market Growth CAGR of 9%. Market Trends Product launches and research for cancer stem cell therapeutics.

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Cancer Stem Cell Therapeutics Market has maintained a steady growth rate in the past decade and is predicted to grow at a higher growth rate during the forecast period. The analysis offers an industry-wide evaluation of the market by looking at vital aspects like growth trends, drivers, constraints, opinions of industry experts, facts and figures, historical information, and statistically-backed and trade valid market information to predict the future market growth.

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Cancer Stem Cell Therapeutics Market Provides in-depth analysis of the Cancer Stem Cell Therapeutics Industry, with current trends and future...

Cell Proliferation Kit Market in the Rear-View Mirror | Overcome Challenges with In-depth insights on Historical Facts & Influencing Factors -…

By adminJuly 10, 2020Stell Cell Research

AMA Research added a comprehensive research document of 200+ pages on Cell Proliferation Kit market with detailed insights on growth factors and strategies. The study segments key regions that includes North America, Europe, Asia-Pacific with country level break-up and provide volume* and value related cross segmented information by each country. Some of the important players from a wide list of coverage used under bottom-up approach are Bio-Rad Laboratories (United States), F. Hoffmann-La Roche (Switzerland), GENERAL ELECTRIC (United Kingdom), Merck (Germany), PerkinElmer (United States), Thermo Fisher Scientific (United States), Biological Industries (Israel), BD Biosciences (United States), Biotium (United States), Mindray Medical (China).

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Cell proliferation kits are known as assays which deliver the deep and quick quantification of cell proliferation and viability. They are basically used to analyze pharmaceutical compounds and agents which are toxic and quantify cell proliferation in the context of the growth factors, mitogens, and nutrients. It is a colorimetric assay for quantification of nonradioactive cellular proliferation, cytotoxicity, and viability. The sample material is either suspension or adherent cells cultured in the 96-well microplates.

Market Segmentation & Scope

Study by Type (Colorimetric Detection Method, Fluorescent Detection Method, Other), Application (Clinical, Industrial & Applied Science, Stem Cell Research), Cell (Human Cells, Animal Cells, Microbial Cells)

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A View on Influencing Trends: Increasing importance of promotional activities

Introduction of technologically advanced products

Growth Drivers in Limelight: Rise in applications of cell proliferation kits

Increase in awareness regarding benefits of cell proliferation kits over traditional treatments Major Roadblocks Worthy Attention: Dearth of skilled professionals

High cost of cell analysis systems

Check Complete Table of Content @ https://www.advancemarketanalytics.com/reports/631-global-cell-proliferation-kit-market

Country level Break-up includes: North America (United States, Canada and Mexico) Europe (Germany, France, United Kingdom, Spain, Italy, Netherlands, Switzerland, Nordic, Others) Asia-Pacific (Japan, China, Australia, India, Taiwan, South Korea, Middle East & Africa, Others)

Limited scope research document specific to Country or Region meeting your business objective.

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Some Strategic Points Covered in Table of Content of Global Cell Proliferation Kit Market:

Chapter 1: Introduction, market driving force product Objective of Study and Research Scope the Cell Proliferation Kit market

Chapter 2: Exclusive Summary the basic information of the Cell Proliferation Kit Market.

Chapter 3: Displaying the Market Dynamics- Drivers, Trends and Challenges of the Cell Proliferation Kit

Chapter 4: Presenting the Cell Proliferation Kit Market Factor Analysis Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis.

Chapter 5-7: Displaying the by Type, End User and Region 2014-2019. Evaluating the leading manufacturers of the Cell Proliferation Kit market which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix & Company Profile. Market Estimates by segments, by countries and by manufacturers with revenue share and sales by key countries in these various countries (2020-2025).

Chapter 8 & 9: Displaying the Appendix, Methodology and Data Source Finally, Cell Proliferation Kit Market is a valuable source of guidance for individuals and companies.

How Research Study of AMA helps clients in their decision making:

Opportunity That Market Giants are Watching: Lucrative opportunities in emerging markets

Growing APAC market

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Thanks for reading this article, you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.

About Author:

Advance Market Analytics is Global leaders of Market Research Industry provides the quantified B2B research to Fortune 500 companies on high growth emerging opportunities which will impact more than 80% of worldwide companies revenues.

Our Analyst is tracking high growth study with detailed statistical and in-depth analysis of market trends & dynamics that provide a complete overview of the industry. We follow an extensive research methodology coupled with critical insights related industry factors and market forces to generate the best value for our clients. We Provides reliable primary and secondary data sources, our analysts and consultants derive informative and usable data suited for our clients business needs. The research study enable clients to meet varied market objectives a from global footprint expansion to supply chain optimization and from competitor profiling to M&As.

Contact Us: Craig Francis (PR & Marketing Manager) AMA Research & Media LLP Unit No. 429, Parsonage Road Edison, NJ New Jersey USA 08837 Phone: +1 (206) 317 1218 [emailprotected]

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Cell Proliferation Kit Market in the Rear-View Mirror | Overcome Challenges with In-depth insights on Historical Facts & Influencing Factors -...

3D Cell Culture Market Provides in-depth analysis of the 3D Cell Culture Industry, with current trends and future estimations to elucidate the…

By adminJuly 10, 2020Stell Cell Research

Reports and Data sheds light on the market scope, potential, and performance perspective of the Global 3D Cell Culture Market by carrying out an extensive market analysis. The global 3D Cell Culture market report is designed to offer a holistic understanding of the market structure including the historical, existing, and predictions for the estimated growth of the market in the forecast period. The study offers precise assessments and projections for the market value, share, production capacity, demand, and growth of the industry in the forecast period by the year 2027.

This is the latest report, covering the current COVID-19 scenario. The Coronavirus pandemic has greatly affected the global industry. It has brought along various changes in market conditions. The rapidly changing market scenario and the initial and future assessment of the impact are covered in the research report. The report discusses all major aspects of the market with expert opinions on the current status along with a historical analysis.

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The report also emphasizes the initiatives undertaken by the companies operating in the market including product innovation, product launches, and technological development to help their organization offer more effective products in the market. It also studies notable business events, including corporate deals, mergers and acquisitions, joint ventures, partnerships, product launches, and brand promotions.

In market segmentation by manufacturers, the report covers the following companies-

Advanced Biomatrix, 3D Biotek, corning Incorporated, Becton and Dickinson Company (BD), Thermo Fisher scientific Inc., Global cell solutions Inc., Nanofiber solutions, VWR Corporation, Synthecon incorporated, Lonza Group Ltd., and Tecan Trading AG., among others.

3D Cell Culture product types, applications, geographies, and end-user industries are the key market segments that are comprised in this study. The report speculates the prospective growth of the different market segments by studying the current market standing, performance, demand, production, sales, and growth prospects existing in the market.

In market segmentation by applications of the 3D Cell Culture , the report covers the following uses-

End users Outlook (Revenue, USD Billion; 2018-2026)

The regional segmentation includes the present and forecast demand for the 3D Cell Culture Market in North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. It covers the individual application segments of the market in each region.

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Get to know the business better:The global 3D Cell Culture market research is carried out at the different stages of the business lifecycle from the production of a product, cost, launch, application, consumption volume and sale. The research offers valuable insights into the marketplace from the beginning including some sound business plans chalked out by prominent market leaders to establish a strong foothold and expand their products into one thats better than others.

The global 3D Cell Culture market report answers some important questions for you:

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The research report by Reports and Data analyzes and forecasts the 3D Cell Culture Market at the global and regional levels. The market has been projected in terms of volume and price for the forecast period. The report also sheds light on the various opportunities within the market.

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3D Cell Culture Market Provides in-depth analysis of the 3D Cell Culture Industry, with current trends and future estimations to elucidate the...

Research Report and Overview on Canine Arthritis Treatment Market, 2019-2026 – Cole of Duty

By adminJuly 10, 2020Stell Cell Research

The Canine Arthritis Treatment Market research report added by Market Study Report, LLC, provides a succinct analysis on the recent market trends. In addition, the report offers a thorough abstract on the statistics, market estimates and revenue forecasts, which further highlights its position in the industry, in tandem with the growth strategies adopted by leading industry players.

The Canine Arthritis Treatment market study is a well-researched report encompassing a detailed analysis of this industry with respect to certain parameters such as the product capacity as well as the overall market remuneration. The report enumerates details about production and consumption patterns in the business as well, in addition to the current scenario of the Canine Arthritis Treatment market and the trends that will prevail in this industry.

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What pointers are covered in the Canine Arthritis Treatment market research study?

The Canine Arthritis Treatment market report Elucidated with regards to the regional landscape of the industry:

The geographical reach of the Canine Arthritis Treatment market has been meticulously segmented into United States, China, Europe, Japan, Southeast Asia & India, according to the report.

The research enumerates the consumption market share of every region in minute detail, in conjunction with the production market share and revenue.

Also, the report is inclusive of the growth rate that each region is projected to register over the estimated period.

The Canine Arthritis Treatment market report Elucidated with regards to the competitive landscape of the industry:

The second dominant market in canine arthritis treatment is Germany owing to the rise in prevalence of chronic diseases in animals, particularly dogs. It has been found that with growing age of pets, the prevalence of diseases such as allergies, lower appetite, reduced energy, arthritis, lameness, dysplasia and behavioural anxieties increases, especially in dogs and cats. This growth in terms of pet adoption in European countries and increasing number of pets suffering from arthritis is likely to boost the growth of canine arthritis treatment in Europe. This has been driving the demand for innovative therapies and drugs in Canine Arthritis Treatment, such as stem cell Canine Arthritis Treatment and arthritis drugs NSAIDs and opioids. Canine arthritis treatment/drugs in Germany have taken initiatives to incentivize innovation in the field of veterinary treatment in order to address the urgent need of better veterinary care and to combat rapid growing prevalence of animal diseases. Additionally, increasing expenditure on vet care in high economic European countries such as Germany, France and the U.K. also boosts the growth of the market for canine arthritis treatment. As per the American Pet Products Association, about US$ 6.1 Bn was spent on vet care in 2017 in Europe.

Increasing pet adoption in China and India is expected to drive the growth of the canine arthritis treatment market in Asia-Pacific. In Japan and the Middle East and Africa, the population of dogs is decreasing due to poor vet care facilities, which is expected to hamper the growth of canine arthritis treatment market to some extent.

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Exclusive details pertaining to the contribution that every firm has made to the industry have been outlined in the study. Not to mention, a brief gist of the company description has been provided as well.

Substantial information subject to the production patterns of each firm and the area that is catered to, has been elucidated.

The valuation that each company holds, in tandem with the description as well as substantial specifications of the manufactured products have been enumerated in the study as well.

The Canine Arthritis Treatment market research study conscientiously mentions a separate section that enumerates details with regards to major parameters like the price fads of key raw material and industrial chain analysis, not to mention, details about the suppliers of the raw material. That said, it is pivotal to mention that the Canine Arthritis Treatment market report also expounds an analysis of the industry distribution chain, further advancing on aspects such as important distributors and the customer pool.

The Canine Arthritis Treatment market report enumerates information about the industry in terms of market share, market size, revenue forecasts, and regional outlook. The report further illustrates competitive insights of key players in the business vertical followed by an overview of their diverse portfolios and growth strategies.

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Some of the Major Highlights of TOC covers:

CIRM Alpha Stem Cell Clinic | UC San Diego Health

By adminJuly 10, 2020Stem Cell Medicine

An overview of the CIRM Alpha Stem Cell Clinic at UC San Diego Health

The mission of the Alpha Stem Cell Clinic at UC San Diego Health is to accelerate the development, implementation and administration of safe and effective stem cell-based human therapies.

The Alpha Stem Cell Clinic at UC San Diego Health is one of five alpha clinics in a network designated by the California Institute for Regenerative Medicine (CIRM), the states stem cell agency. It is the cell therapy arm of the Sanford Stem Cell Clinical Center that specializes in early phase, first-in-human trials. Visit the Sanford Stem Cell Clinical Center's website.

The alpha clinics are intended to create the long-term, networked infrastructure needed to launch and conduct numerous, extensive clinical trials of stem cell-related drugs and therapies in humans, including those developed by independent California-based investigators and companies. These trials are requisite before any new drug or treatment can be approved for clinical use.

The clinics will emphasize public education to raise awareness and understanding of stem cell science. This will combat stem cell tourism and the marketing of unproven, unregulated and potentially dangerous therapies. The clinics will also help establish sustainable business models for future, approved stem cell treatments.

To learn more about participating Alpha Clinics, please visit each clinic's dedicated webpage:

Our current clinical trials include:

Breast Cancer

Chronic Heart Failure

Degenerative Disc Disease

Gastrointestinal

Glioblastoma

Myelodysplastic Syndrome

Find other clinical trials at UC San Diego Health

Learn about how clinical trials work

The Alpha Stem Cell Clinic at UC San Diego Health can provide administrative and other relevant support to scientists and physicians at various stages of development and implementation of clinical trials using stem cell-related therapies.

The Division of Regenerative Medicine at UC San Diego School of Medicine is dedicated to delivering superb state-of-the-art clinical care and bringing the advancement of scientific research in regenerative medicine to the forefront of public and scientific spheres both locally and globally.

The UC San Diego Health / Sharp HealthCare Joint Blood and Marrow Program is the largest blood and marrow transplant (BMT) program in San Diego, one of the largest in California, and a national leader in physician expertise and state-of-the-art treatment.

The Sanford Surgical Training Center supports pre-clinical studies and hands-on training of neurosurgical techniques. Experimental models of spinal and peripheral nerve injury are available for testing pre-clinical cell replacement therapies, clinical immunosuppression protocols in allogeneic and syngeneic cell grafting designs, and organ experimentation and cell grafting. Qualified investigators may be trained on the use of FDA-approved spinal and brain injection devices. The Sanford Surgical Training Center is also working to partner with local contract research organizations (CROs) to develop the infrastructure and administrative support needed to conduct good laboratory practice (GLP) studies.

The UC San Diego Division of Regenerative Medicine will hold its Fifth Annual Symposium on March 15, 2019 at Sanford Consortium for Regenerative Medicine.

This symposium brings together stakeholders from academia, industry, government and the public to discuss developments needed to turn stem cell-based therapies into approved products for patients in need. The program highlights stem cell regeneration in different disease areas and developments with industry partners. An interactive panel will discuss the pitfalls and successes of current stem cell clinical trials.

See the agenda and register for the event

Watch talks from the 2019 symposium on YouTube

Current Enrollment Period: Spring 2019 The UC San Diego CIRM Alpha Stem Cell Clinic is committed to educating patients and professionals, including study staff. We are pleased to invite all clinical research professionals, from coordinators to physicians, to enroll in Translating Stem Cells (CLRE-237).

This 20-hour course is offered via CTRI CREST program. The course may also count as an elective in the MAS program, but applicants do not necessarily need to be enrolled in either the CREST or MAS program to take this course!

The enrollment period is currently closed. Please contact CTRI CREST program with questions, and apply here.

See this downloadable flyer for more information.

Contact

Betty Cabrera, MPH, CCRC Clinical Operations Manager, UC San Diego CIRM Alpha Stem Cell Clinic Phone: 858-534-5932 blcabrera@ucsd.edu

For more information about the program, please contact:

Betty Cabrera, MPH ClinicalOperations Manager, CIRM AlphaStem Cell Clinic

To view the Alpha Clinic's full multidisciplinary team, please see Leadership and Staff.

Meet our stem cell experts in this video playlist

We all have stem cells and they are necessary for our survival. For example, skin stem cells renew and repair our skin. Cells in our bone marrow generate the different cell types in our blood. The stem cells in our bodies are adult stem cells - unspecialized cells found in a tissue or organ that can yield all the specialized types of cells of that tissue or organ.

The term adult stem cells can be misleading because babies and children have them as well. Adult stem cells are also referred to as multipotent stem cells. Multipotent means that they can only generate the cell types in the particular organ in which they are found. However, some studies suggest that under certain conditions, adult stem cells may be able to give rise to cell types of other tissues as well. Another source of multipotent stem cells is umbilical cord blood.

Stem cells that have the potential to generate the cell types in any organ or tissue in the body are called pluripotent stem cells. Embryonic stem cells are pluripotent. Embryonic stem cells come from a blastocyst- a small sphere of cells that results from cell division in a fertilized egg. For research purposes, cells are harvested from the inner cell mass of the blastocyst when it is approximately six days old and consists of around 200 cells. Recently, cells with properties similar to embryonic stem cells, referred to as induced pluripotent stem cells or iPS cells, have been engineered from specialized cells such as skin cells.

Given their unique abilities to renew themselves, researchers are exploring different avenues for using stem cells to treat disease, including:

Stem cells offer tremendous potential to advance medicine; however, current applications may be sometimes exaggerated by the media and others who may not fully understand the science or limitations. Treatments based on stem cells are largely new and there is much we still need to learn. Researchers believe it may take many years, possibly decades in some cases, to realize the full potential of stem cells to treat disease.

UC San Diego Health doctors, researchers and ethicists advise that it is unethical to charge patients for treatments that have not been validated. Unfortunately, there are people who have taken advantage of stem cell publicity to charge fees for treatments that have not been adequately tested for safety and effectiveness. Alleged treatments are offered for a variety of conditions. The Sanford Stem Cell Clinical Center believes that companies often inaccurately portray treatments as safe and effective for a broad range of injury and disease. Potential side effects are downplayed and testimonials are presented instead of evidence from research articles in reputable scientific journals.

The International Society for Stem Cell Research (ISSCR) has expressed concerns about disreputable clinics.

Numerous clinics around the world are exploiting patients hopes by purporting to offer new and effective stem cell therapies for seriously ill patients, typically for large sums of money and without credible scientific rationale, transparency, oversight, or patient protections. The ISSCR is deeply concerned about the potential physical, psychological, and financial harm to those who pursue unproven stem cell therapies and the general lack of scientific transparency and professional accountability of those engaged in these activities.

See"Nine Things To Know About Stem Cell Treatments" for more information.

You can search for new clinical trials, and changes in existing trials at the U.S. National Institutes of Health database:

If you see trials that are of interest to you, we recommend that you read about them carefully, and then print the trial descriptions out for discussion with your doctor. Please keep in touch with respected physicians whom you know and trust for all aspects of your health care.

The rest is here:
CIRM Alpha Stem Cell Clinic | UC San Diego Health

Stem Cell Assay Industry 2020 Includes The Major Application Segments And Size In The Global Market To 2026 – Sports Skylark

By adminJuly 10, 2020Stem Cell Medicine

Dataintelo offers a latest published report on Global Stem Cell Assay Market industry analysis and forecast 20192025 delivering key insights and providing a competitive advantage to clients through a detailed report. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. The report contains XX pages which highly exhibits on current market analysis scenario, upcoming as well as future opportunities, revenue growth, pricing and profitability.

Stem Cell Assay Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments and geographical analysis. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report. The report contains basic, secondary and advanced information pertaining to the Stem Cell Assay global status and trend, market size, share, growth, trends analysis, segment and forecasts from 20192025.

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The scope of the report extends from market scenarios to comparative pricing between major players, cost and profit of the specified market regions. The numerical data is backed up by statistical tools such as SWOT analysis, BCG matrix, SCOT analysis, and PESTLE analysis. The statistics are represented in graphical format for a clear understanding on facts and figures.

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The generated report is firmly based on primary research, interviews with top executives, news sources and information insiders. Secondary research techniques are implemented for better understanding and clarity for data analysis.

The Report Segments for Stem Cell Assay Market Analysis & Forecast 20192025 are as: Global Stem Cell Assay Market, by Products Viability Purification Identification

Global Stem Cell Assay Market, by Applications Regenerative Medicine Clinical Research

The Major Players Reported in the Market Include: GE Healthcare Promega Corporation Thermo Fisher Scientific Merck KGaA Cell Biolabs Hemogenix

The Global Stem Cell Assay Market industry Analysis and Forecast 20192025 helps the clients with customized and syndicated reports holding a key importance for professionals entailing data and market analytics. The report also calls for market driven results deriving feasibility studies for client needs. Dataintelo ensures qualified and verifiable aspects of market data operating in the real time scenario. The analytical studies are conducted ensuring client needs with a thorough understanding of market capacities in the real time scenario.

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Stem Cell Assay Industry 2020 Includes The Major Application Segments And Size In The Global Market To 2026 - Sports Skylark

Jennifer Aydin Gets PRP Scalp Injections for Thinning Hair – Bravo

By adminJuly 10, 2020Platelet Rich Plasma Injections

July 10, 2020, 2:42 PM ET

The RHONJ mom captured her recent visit to her husband's plastic surgery practice.

Jennifer Aydin has always been open about the cosmetic procedures she has undergone in the past, including a tummy tuck and a breast reduction surgery. Now, shes sharing how shes dealing with thinning hair, thanks to a little help from her plastic surgeon husband, Bill Aydin.

On July 10, The Real Housewives of New Jersey cast member took to her Instagram Stories to capture her recent visit to her husband's practice, Aydin Plastic Surgery. As she revealed in the clip, the mom of five was there to receive PRP injections, or platelet-rich plasma therapy, which uses the patient's own platelets to speed up healing in affected areas.

We are getting PRP injections in my head scalp, she can be heard explaining.

Jennifer noted that she has been noticing some hair thinning in the front of her head along her hairline. My thinning hair only in my crown, she captioned one clip.

This isnt the first time that Jennifer has opened up about coping with hair loss. Last fall, she also underwent PRP treatment after the use of extensions and tight ponytails led to thinning hair.

Those extensions on my hair last season were brutal, she said of the procedure at the time. And I took them out this summer and my hair's actually getting back to the thickness that it was, which is great but I need a little extra help."

Bravos Style & Living is your window to the fabulous lifestyles of Bravolebrities. Be the first to know about all the best fashion and beauty looks, the breathtaking homes Bravo stars live in, everything theyre eating and drinking, and so much more. Sign up to become a Bravo Insider and get exclusive extras.

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Jennifer Aydin Gets PRP Scalp Injections for Thinning Hair - Bravo