Texas A&M Researchers Use 3D-Printed Biomaterials Laced With Stem Cells To Create Superior Bone Grafts – Texas A&M University Today

NICE ink developed by Texas A&M researchers can be used to 3D print customizable craniofacial implants.

Courtesy of Akhilesh Gaharwar

Subtle variations in the architecture of the 22 bones of the skull give each one of us a unique facial profile. So repairing the shape of skull defects, in the event of a fracture or a congenital deformity, calls for a technique that can be tailored to an individuals face or head structure.

In a new study, researchers at Texas A&M University have combined 3D printing, biomaterial engineering and stem cell biology to create superior, personalized bone grafts. When implanted at the site of repair, the researchers said these grafts will not only facilitate bone cells to regrow vigorously, but also serve as a sturdy platform for bone regeneration in a desired, custom shape.

Materials used for craniofacial bone implants are either biologically inactive and extremely hard, like titanium, or biologically active and too soft, like biopolymers, said Roland Kaunas, associate professor in the Department of Biomedical Engineering. In our study, we have developed a synthetic polymer that is both bioactive and mechanically strong. These materials are also 3D printable, allowing custom-shaped craniofacial implants to be made that are both aesthetically pleasing and functional.

A detailed report on the findings was published online in the journalAdvanced Healthcare Materialsin March.

Each year, about 200,000 injuries occur to bones of the jaw, face and head. For repair, physicians often hold these broken bones in place using titanium plates and screws so that surrounding bone cells can grow and form a cover around the metal implant. Despite its overall success in aiding bone repair, one of the major drawbacks of titanium is that it does not always integrate into bone tissue, which can then cause the implant to fail, requiring another surgery in advanced cases.

Thus, biocompatible polymers, particularly a type called hydrogels, offer a preferable alternative to metal implants. These squishy materials can be loaded with bone stems cells and then 3D printed to any desired shape. Also, unlike titanium plates, the body can degrade hydrogels over time. However, hydrogels also have a known weakness.

Although the pliability of hydrogel-based materials makes them good inks for 3D bioprinting, their softness compromises the mechanical integrity of the implant and the accuracy of printed parts, said Akhilesh Gaharwar, associate professor in the Department of Biomedical Engineering.

To increase the stiffness of the hydrogel, the researchers developed a nanoengineered ionic-covalent entanglement or NICE recipe containing just three main ingredients: an extract from seaweed called kappa carrageenan, gelatin and nanosilicate particles that both stimulate bone growth and mechanically reinforce the NICE hydrogel.

First, they uniformly mixed the gelatin and kappa carrageenan at microscopic scales and then added the nanosilicates. Gaharwar said the chemical bonds between these three items created a much stiffer hydrogel for 3D bioprinting with an almost eight-fold increase in strength compared to individual components of NICE bioink.

Next, they added adult stem cells to 3D parts printed with NICE ink and then chemically induced the stem cells to convert into bone cells. Within a couple of weeks, the researchers found that the cells had grown in numbers, producing high levels of bone-associated proteins, minerals and other molecules. In aggregate, these cell secretions formed a scaffold, known as an extracellular matrix, with a unique composition of biological materials needed for the growth and survival of developing bone cells.

When the scaffolds are fully developed, the researchers noted that the bone cells could be removed from the scaffold and the hydrogel-based implant can then be inserted into the site of skull injury where the surrounding, healthy bones initiate healing.Over time, the 3D printed scaffolds biodegrade, leaving behind a healed bone in the right shape.

The idea is to have the bodys own bone repair machinery participate in the repair process, Kaunas said. Our biomaterial is enriched with this regenerative extracellular matrix, providing a fertile environment to naturally trigger bone and tissue restoration.

The researchers said that the 3D-printed scaffolds provide a strong structural framework that facilitates the attachment and growth of healthy bone cells. Also, they found that developing bone cells penetrate through the synthetic material, thereby increasing the functionality of the implant.

Although our current work is focused on repairing skull bones, in the near future, we would like to expand this technology for not just craniomaxillofacial defects but also bone regeneration in cases of spinal fusions and other injuries, Kaunas said.

Other contributors to this study include Candice Sears, Eli Mondragon, Zachary Richards, Nick Sears and David Chimene from the Texas A&M Department of Biomedical Engineering; and Eoin McNeill and Carl A. Gregory from the Texas A&M Health Science Center.

This research is funded by the National Institutes of Health and the National Science Foundation.

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Latest Update 2020: Canine Stem Cell Therapy Market by COVID19 Impact Analysis And Top Manufacturers: VETSTEM BIOPHARMA, Cell Therapy Sciences,…

InForGrowth Market Research offers a most recent distributed report on Global Canine Stem Cell Therapy industry examination and figure 2019-2025 conveying key bits of knowledge and giving an upper hand to customers through a point by point report. The report contains XX pages which profoundly displays on current market investigation situation, up and coming just as future chances, income development, evaluating and gainfulness. The Global pandemic of COVID19 calls for redefining of business strategies. This Canine Stem Cell Therapy Market report includes the impact analysis necessary for the same

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By Product Type: Allogeneic Stem Cells, Autologous Stem cells

By Applications: Veterinary Hospitals, Veterinary Clinics, Veterinary Research Institutes

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Potential impact of coronavirus outbreak on Stem Cell Antibody Market: Opportunities and Forecast Assessment, 2019-2025 – 3rd Watch News

The research study presented in this report offers complete and intelligent analysis of the competition, segmentation, dynamics, and geographical advancement of the Global Stem Cell Antibody Market. The research study has been prepared with the use of in-depth qualitative and quantitative analyses of the global Stem Cell Antibody market. We have also provided absolute dollar opportunity and other types of market analysis on the global Stem Cell Antibody market.

It takes into account the CAGR, value, volume, revenue, production, consumption, sales, manufacturing cost, prices, and other key factors related to the global Stem Cell Antibody market. All findings and data on the global Stem Cell Antibody market provided in the report are calculated, gathered, and verified using advanced and reliable primary and secondary research sources. The regional analysis offered in the report will help you to identify key opportunities of the global Stem Cell Antibody market available in different regions and countries.

The report on the Stem Cell Antibody market provides a birds eye view of the current proceeding within the Stem Cell Antibody market. Further, the report also takes into account the impact of the novel COVID-19 pandemic on the Stem Cell Antibody market and offers a clear assessment of the projected market fluctuations during the forecast period.

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The authors of the report have segmented the global Stem Cell Antibody market as per product, application, and region. Segments of the global Stem Cell Antibody market are analyzed on the basis of market share, production, consumption, revenue, CAGR, market size, and more factors. The analysts have profiled leading players of the global Stem Cell Antibody market, keeping in view their recent developments, market share, sales, revenue, areas covered, product portfolios, and other aspects.

The following manufacturers are covered:Thermo Fisher Scientific, Inc. (U.S.)Merck Group (Germany), Abcam plc (U.K.)Becton, Dickinson and Company (U.S.)Bio-Rad Laboratories, Inc. (U.S.)Cell Signaling Technology, Inc. (U.S.)Agilent Technologies, Inc. (U.S.)F. Hoffmann-La Roche Ltd (Switzerland)Danaher Corporation (U.S.)GenScript (U.S.), PerkinElmer, Inc. (U.S.)Lonza (Switzerland), and BioLegend, Inc. (U.S.)

Segment by RegionsNorth AmericaEuropeChinaJapanSoutheast AsiaIndia

Segment by TypePrimary AntibodiesSecondary Antibodies

Segment by ApplicationProteomicsDrug DevelopmentGenomics

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Stem Cell Antibody Market Size and Forecast

In terms of region, this research report covers almost all the major regions across the globe such as North America, Europe, South America, the Middle East, and Africa and the Asia Pacific. Europe and North America regions are anticipated to show an upward growth in the years to come. While Stem Cell Antibody Market in Asia Pacific regions is likely to show remarkable growth during the forecasted period. Cutting edge technology and innovations are the most important traits of the North America region and thats the reason most of the time the US dominates the global markets. Stem Cell Antibody Market in South, America region is also expected to grow in near future.

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Canine Stem Cell Therapy Market Will Make a Huge Impact in Near Future – Cole of Duty

A synopsis of the global canine stem cell therapy market with reference to the global healthcare pharmaceutical industry

Despite the economic and political uncertainty in the recent past, the global healthcare industry has been receiving positive nudges from reformative and technological disruptions in medical devices, pharmaceuticals and biotech, in-vitro diagnostics, and medical imaging. Key markets across the world are facing a massive rise in demand for critical care services that are pushing global healthcare spending levels to unimaginable limits.

A rapidly multiplying geriatric population; increasing prevalence of chronic ailments such as cancer and cardiac disease; growing awareness among patients; and heavy investments in clinical innovation are just some of the factors that are impacting the performance of the global healthcare industry. Proactive measures such as healthcare cost containment, primary care delivery, innovation in medical procedures (3-D printing, blockchain, and robotic surgery to name a few), safe and effective drug delivery, and well-defined healthcare regulatory compliance models are targeted at placing the sector on a high growth trajectory across key regional markets.

Parent Indicators Healthcare Current expenditure on health, % of gross domestic product Current expenditure on health, per capita, US$ purchasing power parities (current prices, current PPPs) Annual growth rate of current expenditure on health, per capita, in real terms Out-of-pocket expenditure, % of current expenditure on health Out-of-pocket expenditure, per capita, US$ purchasing power parity (current prices, current PPPs) Physicians, Density per 1000 population (head counts) Nurses, Density per 1000 population (head counts) Total hospital beds, per 1000 population Curative (acute) care beds, per 1000 population Medical technology, Magnetic Resonance Imaging units, total, per million population Medical technology, Computed Tomography scanners, total, per million population

Research Methodology

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XploreMR utilizes a triangulation methodology that is primarily based on experimental techniques such as patient-level data, to obtain precise market estimations and insights on Molecule and Drug Classes, API Formulations and preferred modes of administration. Bottom-up approach is always used to obtain insightful data for the specific country/regions. The country specific data is again analysed to derive data at a global level. This methodology ensures high quality and accuracy of information.

Secondary research is used at the initial phase to identify the age specific disease epidemiology, diagnosis rate and treatment pattern, as per disease indications. Each piece of information is eventually analysed during the entire research project which builds a strong base for the primary research information.

Primary research participants include demand-side users such as key opinion leaders, physicians, surgeons, nursing managers, clinical specialists who provide valuable insights on trends and clinical application of the drugs, key treatment patterns, adoption rate, and compliance rate.

Quantitative and qualitative assessment of basic factors driving demand, economic factors/cycles and growth rates and strategies utilized by key players in the market is analysed in detail while forecasting, in order to project Year-on-Year growth rates. These Y-o-Y growth projections are checked and aligned as per industry/product lifecycle and further utilized to develop market numbers at a holistic level.

On the other hand, we also analyse various companies annual reports, investor presentations, SEC filings, 10k reports and press release operating in this market segment to fetch substantial information about the market size, trends, opportunity, drivers, restraints and to analyse key players and their market shares. Key companies are segmented at Tier level based on their revenues, product portfolio and presence.

Please note that these are the partial steps that are being followed while developing the market size. Besides this, forecasting will be done based on our internal proprietary model which also uses different macro-economic factors such as per capita healthcare expenditure, disposable income, industry based demand driving factors impacting the market and its forecast trends apart from disease related factors.

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Standard Report Structure Executive Summary Market Definition Macro-economic analysis Parent Market Analysis Market Overview Forecast Factors Segmental Analysis and Forecast Regional Analysis Competition Analysis

Target Audience Production Companies Suppliers Channel Partners Marketing Authorities Subject Matter Experts Research Institutions Financial Institutions Market Consultants Government Authorities

Market Taxonomy

The global canine stem cell therapy market has been segmented into:

Product Type: Allogeneic Stem Cells Autologous Stem cells

Application: Arthritis Dysplasia Tendonitis Lameness Others

End User: Veterinary Hospitals Veterinary Clinics Veterinary Research Institutes

Region: North America Latin America Europe Asia Pacific Japan Middle East & Africa

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Canine Stem Cell Therapy Market Will Make a Huge Impact in Near Future - Cole of Duty

BHU prepares to be amongst top 500 global universities – Hindustan Times

With an aim to be a part of top 500 universities of the world, Banaras Hindu University (BHU) is expanding its international hostel, building smart classrooms, upgrading graduate and postgraduate laboratories, and beautifying its campus under the institute of excellence (IoE) scheme, said BHU public relations officer Dr Rajesh Singh.

Giving details of achievements of BHU in last one year, Dr Singh said that the government had sanctioned Rs 1000 crore under IoE scheme a few months ago to the university for upgrading infrastructure, academic and research facilities, laboratories, central and departmental libraries within five years.

Work has already started for upgrading academic and research facilities. The international hostel of 110 rooms is almost ready. It will help the university attract more foreign students.

He said with the financial support of the ministry of human resource development and union ministry of health and family welfare, a super speciality block worth Rs 200 crore has been built in BHU.

After being inaugurated by Prime Minister Narendra Modi, it is already functional. At present, it is providing medical services to Covid-19 patients. It is equipped with operation theatres, and biochemistry lab and pathology.

Moreover, bone marrow transplant and stem cell research centre have also been set up, construction of regional eye centre with an estimated cost of Rs 38.5 crore is about to be completed.

Singh said that with the financial support of union human resource development ministry, a central discovery centre, equipped with state of the art facilities, for research in basic and practical science is also being set up.

A SATHI centre with an estimated cost of Rs 125 crore is being set up in BHU. Under one roof, there will be facilities for innovation, entrepreneurship and development of startups.

He said that a centre for Vedic science has been set up in the university for research and to establish a link between ancient Indian knowledge and modern science. The centre will also work for reestablishing the excellent sources of knowledge, Vedas and its wide area and will also study their effect in understanding modern science and technology.

BHU has also signed an MoU with solar energy corporation for setting up a solar energy centre and a green energy centre for study in this field.

Dr Singh said that 369 research projects worth over Rs 157 crore are underway in the university.

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Global Stem Cell Antibody Market Insights 2020 Demand Growing Rapidly with Major Player- Thermo Fisher Scientific, Merck Group, Abcam plc – Cole of…

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Global Cell Isolation Technology Market 2020 SWOT Analysis & Key Business Strategies by Leading Industry Players and Forecast 2025 – 3rd Watch…

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Leading manufacturers/companies operating at both regional and global levels: Thermo Fisher Scientific, Inc., Merck, Beckman Coulter, Inc., Terumo BCT, BD Biosciences, Bio-Rad Laboratories, Inc., GE Healthcare, Stemcell Technologies,

With the product, the market could be divided into: Centrifugation, Flow Cytometry, Cell Electrophoresis,

With users/application, the market can be split into: Stem cell research, Cancer research, Tissue regeneration, In-vitro diagnostics, Other

By Leading Regions:

Analysts have created this report by gathering information through primary through surveys and interviews and secondary included industry body databases, reputable paid sources, and trade journal methods of data collection. The report includes exhaustive qualitative and quantitative evaluation. Analysts have taken meticulous efforts to take a look at the right and valuable statistics and serve this intelligence document.

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Autologous Stem Cell Transplantation Market: COVID 19 Effect Will Take a Revenue Generation System in a New Level: ANTRIA (CRO), BIOHEART, BRAINSTORM…

(Jan 2020) WMR has released a report on Autologous Stem Cell Transplantation Market 2027. It provides key insights through details and gives customers a competitive advantage. Autologous Stem Cell Transplantation Industry Size, Market Share Value, Competitor Surveys, Industry Outlook and Analytics cover a variety of factors such as geographic analysis, Autologous Stem Cell Transplantation types, applications, and more.

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Following Key Players are Analysed in this Report: ANTRIA (CRO), BIOHEART, BRAINSTORM CELL THERAPEUTICS, CYTORI, DENDREON CORPORATION, FIBROCELL, GENESIS BIOPHARMA, GEORGIA HEALTH SCIENCES UNIVERSITY, NEOSTEM, OPEXA THERAPEUTICS, ORGENESIS, REGENEXX, REGENEUS, TENGION, TIGENIX, VIRXSYS

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Regional Insights of Autologous Stem Cell Transplantation Market

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Autologous Stem Cell Transplantation Market: COVID 19 Effect Will Take a Revenue Generation System in a New Level: ANTRIA (CRO), BIOHEART, BRAINSTORM...