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Morning Update: Canadas data gaps are hurting our ability to fight the pandemic – The Globe and Mail

By Adult Stem Cells

Good morning,

Crucial data gaps are hurting Canadas ability to fight the COVID-19 pandemic, leaving Canadians in the dark about who is being infected or struggling with the devastated economy.

Canada has a long-standing problem of information gaps, The Globe and Mail found in a year-long series, and that has left us vulnerable during public health crises before. But now, these blind spots could blunt the federal economic rescue effort, hide inequities in deaths from the disease and slow our emergence from self-isolation in the months ahead.

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Father Victor Fernandes puts on personal protection equipment prior to visiting with a patient in the COVID-19 intensive care unit at St. Paul's hospital in downtown Vancouver on April 21, 2020.

JONATHAN HAYWARD/The Canadian Press

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Nova Scotia shooting: Premier Stephen McNeil is urging his mourning province to help investigators unravel questions around a gunmans weekend rampage. A new tip line was created specifically for the killings. He acknowledged there is anger over the RCMPs decision not to use the provincial emergency alert system during the 12-hour manhunt, but he asked people to be patient, and wait for answers.

New details are emerging about the chaos that ensued as police tried to capture the killer disguised as an RCMP officer. Audio recordings of first responders communicating on two-way radios provide a glimpse of frantic attempts to help the first victims in the village of Portapique.

A couple pays their respects at a memorial in Portapique, N.S., on April 22, 2020.

Andrew Vaughan/The Canadian Press

Economy: Saskatchewan has laid out a detailed, comprehensive plan to reopen its economy, and is the first province in the country to do so. On May 4, the five phases will begin, opening non-essential medical procedures, and the reopening of provincial parks, campgrounds and golf courses.

In Quebec, Premier Franois Legault is preparing to lay the groundwork next week for a plan to gradually restart the provinces economy and get children back to school.

Rent: Ottawa is proposing to offer commercial rent relief, in the form of loans for landlords of small and medium-sized businesses, that would cover up to 75 per cent of tenants payments for three months, according to sources familiar with the negotiations.

When it comes to investment properties, small landlords across Canada might not qualify for government assistance and are scrambling to figure out how to accommodate rent reductions while making their mortgage payments.

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World news:

Researchers at the University of Oxford are racing to develop a vaccine for COVID-19 and plan to make a million doses of it this summer. The team has been working since January, and clinical trials involving more than 500 volunteers began yesterday. The testing is expected to take several months, but the researchers have already teamed up with manufacturers globally to produce the doses September and millions more by the end of the year. The Globes Paul Waldie reports.

An aerial view of people queuing outside a bank in downtown Quito, Ecuador, on April 22, 2020.

RODRIGO BUENDIA/AFP/Getty Images

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Scheer, Tories refrain from criticizing MP accused of racist comments: People of Asian descent have faced a spike in hate crimes and slurs since the COVID-19 pandemic began in China last year and experts say the comments from an elected official give licence for the attacks to continue.

Child protection organizations seeing significant uptick in predators: In dark-web forums, sexual predators are increasingly discussing the COVID-19 pandemic as an opportunity to exploit children online as they spend more time out of school and on the internet.

Ontarios Serious Fraud Office investigates Bondfield: A special unit of Ontario police officers and prosecutors launched the investigation in 2019, looking into allegations of wrongdoing by a major builder of hospitals, transit stations and other public infrastructure across the province.

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Parents of teen girls killed by Paul Bernardo seek to obtain his file with the parole board: The two families filed for judicial review this month after their requests for the documents under access to information legislation were denied.

MPs seek to overcome hurdle in getting WHO adviser to testify: A parliamentary committee scrutinizing the response to the pandemic is working to get key World Health Organization adviser Bruce Aylward to testify. The WHOs legal counsel has said that Dr. Aylward cannot testify unless he receives authorization from WHO Director-General Tedros Adhanom Ghebreyesus.

World stocks fall on worries over EU stimulus details, coronavirus drug: Global shares fell on Friday, spurred by delays to an agreement on divisive details of the European Unions stimulus package and doubts about progress in the development of drugs to treat COVID-19. In Europe, Britains FTSE 100 was down 0.93 per cent around 6 a.m. ET. Germanys DAX and Frances CAC 40 fell 1.07 per cent and 1.03 per cent, respectively. In Asia, Japans Nikkei fell 0.86 per cent. Hong Kongs Hang Seng fell 0.61 per cent. New York futures were flat. The Canadian dollar was trading at 71.05 U.S. cents.

Canada must protect itself from Americas response to COVID-19

Robyn Urback: It is not implausible that Mr. Trump would retaliate in some sort of petty but potentially grave economic way on supply lines for essential goods, for example if Canada refuses to lift restrictions on non-essential travel if and when the President decides that time is up.

This Ramadan, in solitude, will be more meaningful than ever

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Fatima Al Fahim: But the pandemic need not dampen Ramadan spirits. Physical distancing gives us a reminder of the true meaning of the holy month.

The world has a big China problem now

Campbell Clark: We dont know precisely what happened in China in the early days of COVID-19, but we know some whistle-blowers were stifled and, for whatever reason, officials waited for days to tell the world after learning they faced a serious epidemic.

By Brian Gable

Brian Gable/The Globe and Mail

What you really need is a room edit, not a reno

Especially while in isolation, you may be looking for curatorial guidance, but are keen to avoid the expense of a full interiors overhaul. Some people would rather rip out a wall or buy a bigger house, when all it often takes is reimaging and reworking what you already have, says Joanna Teplin, the Nashville co-founder of the Home Edit. If you want to remodel, read about how you might be able to make the change with what you already have.

Snuppy, right, the first male dog cloned from adult cells by somatic nuclear cell transfer, and the male Afghan hound from which an adult skin cell was taken to clone Snuppy, are seen in this handout photo released in Seoul on Aug. 3, 2005.

Seoul National University via Reuters

Snuppy worlds first cloned dog is born

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If he were born today, Snuppy would be dubbed, in internet lingo, a very good pupper or an excellent doggo. Instead, Snuppy, the first successful clone of a dog, had to settle for merely being hailed as a breakthrough in biotechnology. A team of 45 South Korean researchers, led by stem-cell researcher Hwang Woo-suk, produced the pup using a process called somatic cell nuclear transfer with a cell from the ear of a male Afghan dog, Tai. Snuppy was named for Seoul National University (SNU) and puppy. While other mammals had been cloned successfully starting with Dolly the sheep in 1996 cloning mans best friend proved more challenging. The achievement suggested that, given time and expertise, almost any mammal could be reproduced. Defying concerns that clones would be rife with ailments, Snuppy was generally healthy. He fathered 10 pups by artificial insemination and produced, by stem-cell clone, a litter with three surviving pups. Snuppy died of cancer, a common fate in dogs, just days after his 10th birthday in 2015. Jessie Willms

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Morning Update: Canadas data gaps are hurting our ability to fight the pandemic - The Globe and Mail

Induced pluripotent stem cells and CRISPR reversed diabetes in mice – Drug Target Review

By Induced Pluripotent Stem Cells

Induced pluripotent stem cells made to produce insulin and CRISPR, used to correct a genetic defect, cured Wolfram syndrome in mice.

Using induced pluripotent stem cells (iPSCs) produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used CRISPR-Cas9 to correct a genetic defect that had caused the syndrome. They then implanted the cells into lab mice and cured the unrelenting diabetes in those models.

The findings, from researchers at Washington University School of Medicine in St. Louis, US, suggest this CRISPR-Cas9 technique may hold promise as a treatment for diabetes, particularly the forms caused by a single gene mutation and it also may be useful one day in some patients with the more common forms of diabetes, such as type 1 and type 2.

This is the first time CRISPR has been used to fix a patients diabetes-causing genetic defect and successfully reverse diabetes, said co-senior investigator Dr Jeffrey Millman, an assistant professor of medicine and of biomedical engineering at Washington University. For this study, we used cells from a patient with Wolfram syndrome because, conceptually, we knew it would be easier to correct a defect caused by a single gene. But we see this as a stepping stone toward applying gene therapy to a broader population of patients with diabetes.

Wolfram syndrome is caused by mutations to a single gene, providing the researchers an opportunity to determine whether combining stem cell technology with CRISPR to correct the genetic error also might correct the diabetes caused by the mutation.

Researchers at Washington University School of Medicine in St. Louis have transformed stem cells into insulin-producing cells. They used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals. Shown is a microscopic image of insulin-secreting beta cells (insulin is green) that were made from stem cells produced from the skin of a patient with Wolfram syndrome [credit: Millman lab Washington University].

Millman and his colleagues had previously discovered how to convert human stem cells into pancreatic beta cells. When such cells encounter blood sugar, they secrete insulin. Recently, these researchers developed a new technique to more efficiently convert human stem cells into beta cells that are considerably better at controlling blood sugar.

In this study, they took the additional steps of deriving these cells from patients and using the CRISPR-Cas9 gene-editing tool on those cells to correct a mutation to the gene that causes Wolfram syndrome (WFS1). Then, the researchers compared the gene-edited cells to insulin-secreting beta cells from the same batch of stem cells that had not undergone editing with CRISPR.

In the test tube and in mice with a severe form of diabetes, the newly grown beta cells that were edited with CRISPR more efficiently secreted insulin in response to glucose. Diabetes disappeared in mice with the CRISPR-edited cells implanted beneath the skin and the animals blood sugar levels remained in normal range for the entire six months they were monitored. Animals receiving unedited beta cells remained diabetic. Although their newly implanted beta cells could produce insulin, it was not enough to reverse their diabetes.

We basically were able to use these cells to cure the problem, making normal beta cells by correcting this mutation, said co-senior investigator Dr Fumihiko Urano, the Samuel E. Schechter Professor of Medicine and a professor of pathology and immunology. Its a proof of concept demonstrating that correcting gene defects that cause or contribute to diabetes in this case, in the Wolfram syndrome gene we can make beta cells that more effectively control blood sugar. Its also possible that by correcting the genetic defects in these cells, we may correct other problems Wolfram syndrome patients experience, such as visual impairment and neurodegeneration.

Were excited about the fact that we were able to combine these two technologies growing beta cells from induced pluripotent stem cells and using CRISPR to correct genetic defects, Millman said. In fact, we found that corrected beta cells were indistinguishable from beta cells made from the stem cells of healthy people without diabetes.

Moving forward, the process of making beta cells from stem cells should get easier, the researchers said. For example, the scientists have developed less intrusive methods, making iPSCs from blood and they are working on developing stem cells from urine samples.

The study is published in Science Translational Medicine.

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Induced pluripotent stem cells and CRISPR reversed diabetes in mice - Drug Target Review

Reversing diabetes with CRISPR and patient-derived stem cells – FierceBiotech

By Induced Pluripotent Stem Cells

Insulin injections cancontrol diabetes, but patients still experience serious complications such as kidney disease and skin infections. Transplanting pancreatic tissues containing functional insulin-producing beta cells is of limited use, because donors are scarce and patients must take immunosuppressant drugs afterward.

Now, scientists atWashington University in St. Louis havedeveloped a way to use gene editing system CRISPR-Cas9 to edit a mutation in human-induced pluripotent stem cells (iPSCs) and then turnthem into beta cells. When transplanted into mice, the cells reversed preexisting diabetes in a lasting way, according to results published in the journal Science Translational Medicine.

While the researchers used cells from patients with Wolfram syndromea rare childhood diabetes caused by mutations in the WFS1 genethey argue that the combination of a gene therapy with stem cells could potentially treat other forms of diabetes as well.

Virtual Clinical Trials Online

This virtual event will bring together industry experts to discuss the increasing pace of pharmaceutical innovation, the need to maintain data quality and integrity as new technologies are implemented and understand regulatory challenges to ensure compliance.

One of the biggest challenges we faced was differentiating our patient cells into beta cells. Previous approaches do not allow for this robust differentiation. We use our new differentiation protocol targeting different development and signaling pathways to generate our cells, the studys lead author, Kristina Maxwell, explained in a video statement.

Making pancreatic beta cells from patient-derived stem cells requires precise activation and repression of specific pathways, and atthe right times, to guide the development process. In a recent Nature Biotechnology study, the team described a successful method that leverages the link between a complex known as actin cytoskeleton and the expression of transcription factors that drive pancreatic cell differentiation.

This time, the researchers applied the technology to iPSCs from two patients with Wolfram syndrome. They used CRISPR to correct the mutated WFS1 gene in the cells and differentiated the edited iPSCs into fully functional beta cells.

After transplanting the corrected beta cells into diabetic mice, the animals saw their blood glucose drop quickly, suggesting the disease had been reversed. The effect lasted for the entire six-month observation period, the scientists reported. By comparison, those receiving unedited cells from patients were unable to achieve glycemic control.

RELATED:CRISPR Therapeutics, ViaCyte team up on gene-edited diabetes treatment

The idea of editing stem cells with CRISPR has already attracted interest in the biopharma industry. Back in 2018, CRISPR Therapeutics penned a deal with ViaCyte to develop off-the-shelf, gene-editing stem cell therapies for diabetes. Rather than editing iPSCs from particular patients themselves to correct a faulty gene, the pairs lead project used CRISPR to edit healthy cells so that they lackedthe B2M gene and expressed PD-L1 to protect against immune attack. The two companies unveiled positive preclinical data inSeptember.

Other research groups working on gene therapy or stem cells for diabetes include a Harvard University scientist and his startup Semma Therapeutics, whichdeveloped a method for selecting beta cells out of a mixture of cells developed from PSCs. Scientists at the University of Wisconsin-Madison recently proposed that removing the IRE1-alpha gene in beta cells could prevent immune T cells from attacking them in mice with Type 1 diabetes.

The Washington University team hopes its technology may help Type 1 diabetes patients whose disease is caused by multiple genetic and environmental factors as well as the Type 2 form linked to obesity and insulin resistance.

We can generate a virtually unlimited number of beta cells from patients with diabetes to test and discover new drugs to hopefully stop or even reverse this disease, Jeffrey Millman, the studys co-senior author, said in the video statement. Perhaps most importantly, this technology now allows for the potential use of gene therapy in combination with the patients own cells to treat their own diabetes by transplantation of lab-grown beta cells.

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Reversing diabetes with CRISPR and patient-derived stem cells - FierceBiotech

The integrated stress response: From mechanism to disease – Science Magazine

By Induced Pluripotent Stem Cells

Proteostasis dISRupted

Despite their importance, many crucial networks for protein quality control within cells diminish with age. The resulting loss of proteostasis, the process by which the health of a cell's proteins is monitored and maintained, is associated with a wide range of age-related human diseases. Costa-Mattioli and Walter review the integrated stress response (ISR), a central signaling network that responds to proteostasis defects by tuning protein synthesis. The ISR is activated in a wide range of pathological conditions, so a mechanistic understanding of its pathway may help in the development of therapeutic tools through which it can be modulated.

Science, this issue p. eaat5314

The integrated stress response (ISR) is an evolutionarily conserved intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable environment and maintain health. In response to different environmental and pathological conditions, including protein homeostasis (proteostasis) defects, nutrient deprivation, viral infection, and oxidative stress, the ISR restores balance by reprogramming gene expression. The various stresses are sensed by four specialized kinases (PERK, GCN2, PKR and HRI) that converge on phosphorylation of a single serine on the eukaryotic translation initiation factor eIF2. eIF2 phosphorylation blocks the action of eIF2s guanine nucleotide exchange factor termed eIF2B, resulting in a general reduction in protein synthesis. Paradoxically, phosphorylation of eIF2 also triggers the translation of specific mRNAs, including key transcription factors, such as ATF4. These mRNAs contain short inhibitory upstream open reading frames in their 5-untranslated regions that prevent translation initiation at their canonical AUGs. By tuning down general mRNA translation and up-regulating the synthesis of a few proteins that drive a new transcriptional program, the ISR aims to maintain or reestablish physiological homeostasis. However, if the stress cannot be mitigated, the ISR triggers apoptosis to eliminate the damaged cell.

Our understanding of the central mechanisms that govern the ISR has advanced vastly. The ISRs central regulatory hub lies in the eIF2eIF2B complex, which controls the formation of the eIF2GTPmethionyl-intiator tRNA ternary complex (TC), a prerequisite for initiating new protein synthesis. Assembly of functional TC is inhibited by eIF2-P, which blocks eIF2B noncompetitively. In mammalian cells, the phosphorylation of eIF2 is a tightly regulated process. In addition to the four specialized eIF2 kinases that phosphorylate eIF2, two dedicated phosphatases antagonize this reaction. Both phosphatases contain a common catalytic core subunit, the protein phosphatase 1 (PP1), and a regulatory subunit (GADD34 or CReP), which render the phosphatase specific to eIF2. Structural and biophysical approaches have elucidated the mechanism of action of eIF2B and its modulation by ISR inhibitors and activators. Gene expression analyses have revealed complex ISR-driven reprogramming. Although it has been long recognized that, in the brain, long-term memory formation requires new protein synthesis, recent causal and convergent evidence across different species and model systems has shown that the ISR serves as a universal regulator of this process. Briefly, inhibition of the ISR enhances long-term memory formation, whereas activation of the ISR prevents it. Consistent with this notion, unbiased genome-wide association studies have identified mutations in key components of the ISR in humans with intellectual disability. Furthermore, age-related cognitive disorders are commonly associated with the activation of the ISR. Most notably, oxidative stress, misfolded proteins, and other stressors induce the ISR in several neurodegenerative disorders, including Alzheimers disease. Recent genetic and pharmacological evidence suggest that tuning the ISR reverses cognitive dysfunction as well as neurodegeneration in a wide range of memory disorders that result from protein homeostasis defects. Thus, long-term memory deficits may primarily result as a consequence of ISR activation rather than from the particular proteostasis defects that lead to its induction. Finally, the ISR is also implicated in the pathogenesis of a plethora of other complex diseases, including cancer, diabetes, and metabolic disorders.

The ISR is emerging as a central regulator of protein homeostasis at both the cellular and organismal level. Mechanistically, much remains to be understood regarding additional inputs into the eIF2BeIF2 regulatory hub controlling TC concentration, as well as the IRSs connectivity to other intracellular signaling networks. As yet, little is known about the role of the specific proteins whose synthesis is altered during acute and persistent ISR activation and how these effectors collaborate to compute the life or death decisions cells make upon ISR activation. ISR gene expression signatures and functional consequences will need to be mapped across different tissues, cell types, and developmental stages. In addition, it will be invaluable to generate additional genetic and molecular tools that permit the direct temporal and spatial manipulation of ISR pathway in specific cells and circuits to determine their function. From a medical perspective, the ISR is implicated in the etiology of several disorders, and manipulation of the ISR is emerging as a promising therapeutic avenue for the treatment of a variety of diseases. The use of innovative mouse models, patient-derived induced pluripotent stem cells, and human organoids will greatly enhance our ability to explore the ISRs clinical relevance further and help define therapeutic windows in which ISR modulation may prove beneficial. Identifying additional specific small-molecule inhibitors and activators of the ISR will offer valuable opportunities to dissect the role of the ISR pharmacologically in health and disease. Finally, discovery and mechanistic understanding of additional ISR modulators will increase the repertoire of therapeutic targets and may further enable clinical development in a wide range of age-related human diseases.

Diverse deviations from homeostasis activate the ISR. The resulting dysregulation of translation contributes to numerous diseases.

Protein quality control is essential for the proper function of cells and the organisms that they make up. The resulting loss of proteostasis, the processes by which the health of the cells proteins is monitored and maintained at homeostasis, is associated with a wide range of age-related human diseases. Here, we highlight how the integrated stress response (ISR), a central signaling network that responds to proteostasis defects by tuning protein synthesis rates, impedes the formation of long-term memory. In addition, we address how dysregulated ISR signaling contributes to the pathogenesis of complex diseases, including cognitive disorders, neurodegeneration, cancer, diabetes, and metabolic disorders. The development of tools through which the ISR can be modulated promises to uncover new avenues to diminish pathologies resulting from it for clinical benefit.

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The integrated stress response: From mechanism to disease - Science Magazine

Here’s Why Pluristem Therapeutics Jumped Over 28% Today – Motley Fool

By Stem Cell Treatment

What happened

Shares of Pluristem Therapeutics (NASDAQ:PSTI) rose as much as 28.3% today after the company announced it had secured non-dilutive financing from the European Investment Bank (EIB) to support the development of treatments for COVID-19. The stem cell developer is eligible to receive up to $54 million (50 million Euros) in funding in three tranches, with the first $21.5 million expected to be distributed before the end of April.

Pluristem Therapeutics can receive the second and third installments by achieving certain clinical, regulatory, and manufacturing milestones. It won't have to begin repaying the loan until April 2025.

As of 1:08 a.m. EDT, the small-cap stock had settled to a 22.9% gain.

Image source: Getty Images.

Today's financing announcement means Pluristem Therapeutics can hit the ground running to develop stem-cell based treatments for COVID-19. Importantly, it also means the company can limit dilutive fundraising transactions to support research and development (R&D) efforts. But investors might still expect a public stock offering to be conducted soon.

Pluristem Therapeutics expects the $54 million financing from EIB to cover up to 50% of R&D expenses related to its COVID-19 project. The business reported only $16 million in cash on its balance sheet at the end of 2019, which means it will need additional funding -- likely raised from public offerings of common stock -- if the project progresses.

To be blunt, Pluristem Therapeutics is a stem cell stock that doesn't belong in your portfolio. The company sported a market valuation of only $60 million just a few weeks ago, but has climbed to $225 million on recent announcements that it was developing treatments for COVID-19. While fellow stem-cell developer Mesoblast reported promising results today from a small clinical trial, investors cannot extrapolate that to Pluristem Therapeutics. This remains a very risky stock.

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Here's Why Pluristem Therapeutics Jumped Over 28% Today - Motley Fool

Global Animal Stem Cell Therapy Market 2020 Future Scenario, Industry Growth Insights and Production Analysis 2025 – Bandera County Courier

By Stem Cell Treatment

Mrinsights.bizhas published a new report titled GlobalAnimal Stem Cell TherapyMarketGrowth 2020-2025 which comprises new statistical data on the changing market scenario and initial and future assessment of the market. The report covers a wide range of business aspects global Animal Stem Cell Therapy trends, future forecasts, growth opportunities, key end-user industries, and market players. The report analyzes the recent developments, investment opportunities, and probable threats in the market. It closely looks at the markets all-purpose evaluation and depicts the important data associated with the global market.

DOWNLOAD FREE SAMPLE REPORT:https://www.mrinsights.biz/report-detail/232664/request-sample

The report assesses the demand-side and supply-side trends in the global Animal Stem Cell Therapy market. Various segments are scrutinized that involve end-users, regions, and players on the basis of demand patterns, and prospect for 2020 to 2025 time-period. The research report contains a comprehensive database on future market estimation based on historical data analysis. Key players are listed with major collaborations, mergers & acquisitions and upcoming and trending innovation. Primary research involves interviews, news sources and information booths. Secondary research techniques add more in clear and concise understanding with regards to placing of data in the report.

Understanding The Competitive Scenario:

Competitive landscape analysis is presented which involves the global Animal Stem Cell Therapy market share of major players, along with the new projects and strategies adopted by players in the past five years. Comprehensive company profiles comprise the product offerings, key financial information, recent developments, SWOT analysis, capacity, production, price, revenue, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, and strategies employed by the major market players. Additionally, the report covers insights into the production and capacities in terms of manufacturing with price fluctuations of raw materials, process in-flow rate product cost, and production value.

Considering market analysis, the profiled list of companies in the report is:Medivet Biologics LLC, Animal Cell Therapies, VETSTEM BIOPHARMA, U.S. Stem Cell, Inc, VetCell Therapeutics, J-ARM, Kintaro Cells Power, Celavet Inc., Animal Stem Care, Magellan Stem Cells, Cell Therapy Sciences, Animacel

Currently, the research report gives special attention and focus on the following regions:Americas (United States, Canada, Mexico, Brazil), APAC (China, Japan, Korea, Southeast Asia, India, Australia), Europe (Germany, France, UK, Italy, Russia, Spain), Middle East & Africa (Egypt, South Africa, Israel, Turkey, GCC Countries).

Moreover, the report identifies potential customers and suppliers as well as gives an analysis of the companys business structure, operations, major products and services, and business strategy. The study helps you understand the companys core strengths, weaknesses, opportunities, and threats. The report shows factual data about the global Animal Stem Cell Therapy market in the worldwide area, for example, production chain, manufacturing capacity, sales volume, and revenue.

ACCESS FULL REPORT:https://www.mrinsights.biz/report/global-animal-stem-cell-therapy-market-growth-2020-2025-232664.html

The Scope of The Global Animal Stem Cell Therapy Report:

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team (sales@mrinsights.biz), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Global Animal Stem Cell Therapy Market 2020 Future Scenario, Industry Growth Insights and Production Analysis 2025 - Bandera County Courier

FTC Sends 21 Letters Warning Marketers to Stop Making Unsupported Claims That Their Products and Therapies Can Effectively Treat Coronavirus – Sierra…

By Stem Cell Treatment

Supposed therapies range from stem cell infusions to acupuncture and ozone treatments

April 24, 2020 - The Federal Trade Commission announced it has sent 21 additional letters warning marketers throughout the United States to stop making unsubstantiated claims that their products and therapies can treat or prevent coronavirus (COVID-19). This is third set of warning letters the FTC has sent to sellers of such products as part of its ongoing efforts to protect consumers from COVID-19 related scams.

The FTCpreviously sent warning lettersto the sellers of supplements including colloidal silver, teas, essential oils, and other products pitched as scientifically proven coronavirus treatments. The letters announced today, however, address a wider range of products and supposed treatments, including some that may appear more medically sophisticated to consumers, such as acupuncture, intravenous (IV) therapies with high doses of Vitamin C, ozone therapy, and purported stem cell treatments. However, there is currently no scientific evidence that these products or services can treat or cure coronavirus.

The FTC sent the letters announced today to the companies and individuals listed below. The recipients are grouped based on the type of therapy, product, or service they pitched to supposedly prevent or treat coronavirus disease.

General Therapy Products, Vitamins, and Supplements:

IV Therapy and Related Treatments:

Ozone Therapy:

Stem Cell Therapy:

In the letters, the FTC states that one or more of the efficacy claims made by the marketers are unsubstantiated because they are not supported by scientific evidence, and therefore violate the FTC Act. The letters advise the recipients to immediately cease making all claims that their products can treat or cure coronavirus and to notify the FTC within 48 hours about the specific actions they have taken to address the agencys concerns.

The letters note that if the false claims do not cease, the Commission may seek a federal court injunction and an order requiring money to be refunded to consumers.

The letters announced today are the latest round of warnings the FTC has sent to sellers of products pitched as able treat or prevent coronavirus. The Commission also has sentletters to several Voice over Internet Protocol (VoIP) service providers, warning them that it is illegal to aid or facilitate the transmission of pre-recorded telemarketing robocalls pitching supposed coronavirus-related products or services.

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FTC Sends 21 Letters Warning Marketers to Stop Making Unsupported Claims That Their Products and Therapies Can Effectively Treat Coronavirus - Sierra...

Animal Stem Cell Therapy Market Is Set To Experience Revolutionary Growth By 2025 – Cole of Duty

By Stem Cell Treatment

The Animal Stem Cell Therapy report provides independent information about the Animal Stem Cell Therapy industry supported by extensive research on factors such as industry segments size & trends, inhibitors, dynamics, drivers, opportunities & challenges, environment & policy, cost overview, porters five force analysis, and key companies profiles including business overview and recent development.

Animal Stem Cell Therapy MarketLatest Research Report 2020:

Download Premium Sample Copy Of This Report: Download FREE Sample PDF!

In this report, our team offers a thorough investigation of Animal Stem Cell Therapy Market, SWOT examination of the most prominent players right now. Alongside an industrial chain, market measurements regarding revenue, sales, value, capacity, regional market examination, section insightful information, and market forecast are offered in the full investigation, and so forth.

Scope of Animal Stem Cell Therapy Market: Products in the Animal Stem Cell Therapy classification furnish clients with assets to get ready for tests, tests, and evaluations.

Animal Stem Cell Therapy Market Report Covers the Following Segments:

Segment1: By Type, Dogs, Horses, Others, By Application, Veterinary Hospitals, Research Organizations

Market Overview:The report begins with this section where product overview and highlights of product and application segments of the global Animal Stem Cell Therapy Market are provided. Highlights of the segmentation study include price, revenue, sales, sales growth rate, and market share by product.

Competition by Company:Here, the competition in the Worldwide Animal Stem Cell Therapy Market is analyzed, By price, revenue, sales, and market share by company, market rate, competitive situations Landscape, and latest trends, merger, expansion, acquisition, and market shares of top companies.

Company Profiles and Sales Data:As the name suggests, this section gives the sales data of key players of the global Animal Stem Cell Therapy Market as well as some useful information on their business. It talks about the gross margin, price, revenue, products, and their specifications, type, applications, competitors, manufacturing base, and the main business of key players operating in the global Animal Stem Cell Therapy Market.

Market Status and Outlook by Region:In this section, the report discusses about gross margin, sales, revenue, production, market share, CAGR, and market size by region. Here, the global Animal Stem Cell Therapy Market is deeply analyzed on the basis of regions and countries such as North America, Europe, China, India, Japan, and the MEA.

Application or End User:This section of the research study shows how different end-user/application segments contribute to the global Animal Stem Cell Therapy Market.

Market Forecast:Here, the report offers a complete forecast of the global Animal Stem Cell Therapy Market by product, application, and region. It also offers global sales and revenue forecast for all years of the forecast period.

Research Findings and Conclusion:This is one of the last sections of the report where the findings of the analysts and the conclusion of the research study are provided.

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Animal Stem Cell Therapy Market Is Set To Experience Revolutionary Growth By 2025 - Cole of Duty

Stem Cell Therapy Market Overview by 2026: Verified Market Research – Cole of Duty

By Stem Cell Treatment

Allosource

Global Stem Cell Therapy Market Segmentation

This market was divided into types, applications and regions. The growth of each segment provides an accurate calculation and forecast of sales by type and application in terms of volume and value for the period between 2020 and 2026. This analysis can help you develop your business by targeting niche markets. Market share data are available at global and regional levels. The regions covered by the report are North America, Europe, the Asia-Pacific region, the Middle East, and Africa and Latin America. Research analysts understand the competitive forces and provide competitive analysis for each competitor separately.

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Global Stem Cell Therapy Market Regions and Countries Level Analysis

The regional analysis is a very complete part of this report. This segmentation highlights Stem Cell Therapy sales at regional and national levels. This data provides a detailed and accurate analysis of volume by country and an analysis of market size by region of the world market.

The report provides an in-depth assessment of growth and other aspects of the market in key countries such as the United States, Canada, Mexico, Germany, France, the United Kingdom, Russia and the United States Italy, China, Japan, South Korea, India, Australia, Brazil and Saudi Arabia. The chapter on the competitive landscape of the global market report contains important information on market participants such as business overview, total sales (financial data), market potential, global presence, Stem Cell Therapy sales and earnings, market share, prices, production locations and facilities, products offered and applied strategies. This study provides Stem Cell Therapy sales, revenue, and market share for each player covered in this report for a period between 2016 and 2020.

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We offer state of the art critical reports with accurate information about the future of the market.

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We provide a full graphical representation of information, strategic recommendations and analysis tool results to provide a sophisticated landscape and highlight key market players. This detailed market assessment will help the company increase its efficiency.

The dynamics of supply and demand shown in the report offer a 360-degree view of the market.

Our report helps readers decipher the current and future constraints of the Stem Cell Therapy market and formulate optimal business strategies to maximize market growth.

Table of Contents:

Study Coverage: It includes study objectives, years considered for the research study, growth rate and Stem Cell Therapy market size of type and application segments, key manufacturers covered, product scope, and highlights of segmental analysis.

Executive Summary: In this section, the report focuses on analysis of macroscopic indicators, market issues, drivers, and trends, competitive landscape, CAGR of the global Stem Cell Therapy market, and global production. Under the global production chapter, the authors of the report have included market pricing and trends, global capacity, global production, and global revenue forecasts.

Stem Cell Therapy Market Size by Manufacturer: Here, the report concentrates on revenue and production shares of manufacturers for all the years of the forecast period. It also focuses on price by manufacturer and expansion plans and mergers and acquisitions of companies.

Production by Region: It shows how the revenue and production in the global market are distributed among different regions. Each regional market is extensively studied here on the basis of import and export, key players, revenue, and production.

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Tags: Stem Cell Therapy Market Size, Stem Cell Therapy Market Trends, Stem Cell Therapy Market Forecast, Stem Cell Therapy Market Growth, Stem Cell Therapy Market Analysis

Original post:
Stem Cell Therapy Market Overview by 2026: Verified Market Research - Cole of Duty

Researcher says stem cell activation could lie at root of health effects of many natural products – NutraIngredients-usa.com

By Stem Cell Medicine

Gitte Jensen, PhD, is the principal of NIS Labs, a contract research organization based in Klamath Falls, OR. For several decades, starting with a postdoc stint at the Cross Cancer Institute at the University of Alberta, then running her own lab at McGill University in Montreal and at NIS Labs, which she founded in 1999, Jensen has studied how the human body activates and employs stem cells. These initially undifferentiated cells are the foundation of the bodys repair machinery and also play a key role in a healthy immune system response.

Jensen has done research which has explored the effects of compounds found in microalgae. As it turns out, Upper Klamath Lake, which abuts the city of Klamath Falls, plays host every year to abundant blooms of a particular strain of blue green algae long touted for its health benefits. Jensens expertise in algae research has also been employed in the study of astaxanthin-rich Haematococcus pluvialis.

Recently Jensens attention has been focused on compounds found in sea buckthorn berries. Sea buckthorn is a thorny, perennial shrub native to many parts of Asia as well as Northwestern Europe. The best berries with the most bioactives are harvested in various high altitude locations in the Himalayan region.

The plant has long been revered for its medicinal properties. Legend has it that during his push into Asia Alexander the Great released horses injured in battle to fare as they might in an area with many of the shrubs. The horses not only survived but prospered and when the Greeks next looked in on them they found a herd notable for their shiny coats, an outward sign of health. Thus the name of the plant: Hippophae, which combines the Greek words for horse and shiny.

Similar legends hold that Genghis Khan instructed his troops to carry the berries to speed recovery from war wounds. Jensen said the berries of the plant have been an ingredient in Chinese, Tibetan and Mongolian herbal medicine traditions for more than a thousand years.

Jensen conducted a small scale, randomized double-blind, placebo-controlled crossover study to look into how the proanthocyanidins found in the berry affected stem cell activation. The study was published last year in the journal Clinical Interventions in Aging. The study recruited 12 subjects, eight women and four men, who ranged in age an in body composition from slender to borderline obese. The subjects consumed 500 mg of a proanthocyanidin-rich sea buckthorn extract or a placebo at two separate visits to the testing facility. Subjects remained calm and at rest for three hours during the administration of the test material (or the placebo). Blood was drawn at one hour for a baseline measurement, and then one hour and two hours after ingestion of the test material. Participants were also screened for confounding factors such as a high state of anxiety or being short on sleep, which could have skewed the results, in which case visits were rescheduled.

Jensen and her co authors found that the sea buckthorn extract significantly increased the level of some specific endothelial stem cells, but not others. The CD45dim CD34+ CD309- cells, CD45dim CD34+ CD309+ cells, and the CD45- CD31+ CD309+ endothelial stem cells showed significant mobilization above placebo within 2 hours, they wrote.

Regardless of the stem cell type, just having more has been shown to be important, Jensen and her coauthors stated. While pluripotential stems cells are the most important type, there are indications that other kinds of stem cellsendothelial, mesenchymal, and hematopoieticcan revert to the pluripotential state and be available for additional repair processes.

When the number of circulating endothelial progenitor cells was quantified in the blood of 509 individuals at risk for cardiovascular disease and the incidence of cardiovascular events in these individuals was monitored for 1 year, a significantly greater number of events took place in the individuals having fewer circulating stem cells, they said.

By documenting the ability of SBB-PE (sea buckthorn berries proanthycyanidin-rich extract) to support stem cell mobilization and to increase the number of circulating stem cells, we have uncovered a new mechanism of action behind many of the health benefits that have been historically associated with SBB, they concluded.

Jensen said looking more closely at stem cell activation could change how researchers design their studies and help bring forth more trials that show significant results because there is a better understanding of the underlying mechanisms of action.

When we look at plants that have health properties, we look at whether an underlying protective mechanism might be at work. Every time you take a concentrated dose of sea buckthorn extract you make a concerted effortto boost the number of stem cells in your circulation. You kick them into action to go in search of things that need repair, Jensen said.

Jensen said future avenues of research could delver deeper into how this rapid mobilization of stem cells takes place. She said its quite likely that the gut/brain connection is involved, as stem cell levels start to rise before significant amounts of the contents of the berry extract could be digested and cross the blood/gut barrier.

If you are consuming a natural product that works fast it is likely due ot a signal from the gut to the brain likely because of the vagus nerve or other pathways, she said.

Im advocating for a deeper understandingin our industryhow the many natural products we are working with are tapping into and supportingnatural physiological processes, Jensen said.

Source: Clinical Interventions in AgingDOI: 10.2147/CIA.S186893Rapid and Selective Mobilization of Specific Stem Cell Types After Consumption of a Polyphenol-Rich Extract From Sea Buckthorn Berries ( Hippophae) in Healthy Human SubjectsAuthors: Drapeau C, Benson KF, Jensen GS

Original post:
Researcher says stem cell activation could lie at root of health effects of many natural products - NutraIngredients-usa.com

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