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ElevateBio reels in $170M to push 6 cell, gene therapy programs – FierceBiotech

Barely a year after launching with $150 million to build cell and gene therapy companies, ElevateBio is at it again. This time, its picking up another $170 million to propel six programs into the clinic and get its centralized R&D and manufacturing hub up and running.

ElevateBio co-founders David Hallal, Mitchell Finer, Ph.D., and Vikas Sinha set up shop to tackle a bottleneck in cell and gene therapy: manufacturing. The holding company provides a centralized R&D and manufacturing site dubbed ElevateBio BaseCamp for its portfolio companies to bring cell and gene therapies from bench to bedside.

Since launch, ElevateBio has inked a 10-year deal with Massachusetts General Hospital to manufacture cell and gene therapies as well as to build cell and gene therapy biotechs. It has also unveiled two companies: AlloVir, which is developing a T-cell therapy that targets multiple viruses, and HighPassBio, which is working on a T-cell receptor treatment for leukemia.

RELATED: ElevateBio uncloaks with $150M to build cell and gene therapy biotechs

The new financing will bankroll the clinical development of six programs in 2020 and 2021, including treatments from AlloVir and HighPassBio as well as those being developed by companies ElevateBio has not yet made public.

[This] represents at least three additional new cell and gene therapies from not yet disclosed ElevateBio portfolio companies that include AAV-gene based technology as well as T-cell based therapeutics and we will launch these companies in the months to come, Hallal, ElevateBios CEO, told FierceBiotech via email.

It plans to start several phase 2 and phase 3 studies for AlloVirs Viralym-M program, which targets six viruses that commonly affect patients who receive stem cell transplants, and move a second program in diseases caused by community-acquired respiratory viruses into the clinic this year, Hallal added.

RELATED: ElevateBio founds HighPassBio to develop Fred Hutch cell therapy

The capital will also fund technology development and get ElevateBio BaseCamp fully operational.

We will continue to build our capabilities at ElevateBio BaseCamp that will increase our leadership position in the space as we have a unique integrated approach for cell and gene manufacturing, enabling technologies, and broad range of therapeutics all under one roof. At BaseCamp we expect to be performing cGMP manufacturing as early as next year, Hallal said.

All of ElevateBios backers returned for the series B round, including F2 Ventures, MPM Capital, EcoR1 Capital, Redmile Group, and Samsara BioCapital. Newcomers The Invus Group, Surveyor Capital, EDBI and Vertex Ventures joined in.

AlloVir, which was founded on technology from the Center for Cell and Gene Therapy at Baylor College of Medicine, has also jumped into the hunt for treatments against the new coronavirus, SARS-CoV-2. It expanded its partnership with Baylor earlier this month to include work on off-the-shelf T-cell treatments that target the virus.

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ElevateBio reels in $170M to push 6 cell, gene therapy programs - FierceBiotech

Stem Cells, Nerves Found to Interact in Cancer Progression – Pharmacy Times

Researchers at the Institute of Oral Biology of the University of Zurich have released 2 studies that examine how stem cells promote neuronal growth in tissue regeneration and in cancer progression.

Their findings demonstrate that different stem cell populations are innervated in distinct ways and that innervation may be crucial for proper tissue regeneration, according to the study. They also demonstrate that cancer steam cells likewise establish contacts with nerves.

Stem cells can generate a variety of specific tissues that are increasingly being used for clinical application, such as the replacement of bone or cartilage, but are present in cancerous tissues and are involved in cancer progression and metastasis. Nerves are therefore fundamental for regulating the physiological and regenerative processes involving stem cells.

Using organ-on-a-chip technology, which relies on small 3-dimensional devices mimicking the basic function of human organs and tissues, the researchers demonstrated that both types of stem cells promoted neuronal growth. The dental pulp stem cells, however, yielded better results compared with bone marrow stem cells. They induced more elongated neurons, formed dense neuronal networks, and established close contacts with nerves.

Dental stem cells produce specific molecules that are fundamental for the growth and attraction of neurons. Therefore, stem cells are abundantly innervated, according to the study authors. The formation of such extended networks and the establishment of numerous contacts suggest that dental stem cells create functional connections with nerves of the face. Therefore, these cells could represent an attractive choice for the regeneration of functional, properly innervated facial tissue.

In the second study, the researchers examined the interaction between nerves and cancer stem cells found in ameloblastoma, an aggressive tumor of the mouth. They first demonstrated that ameloblastomas have stem cell properties and are innervated by facial neurons. When ameloblastoma cells were isolated and placed in the organ-on-a-chip devices, they retained not only their stem cell properties, but also attracted nerves and established contact with them.

Nerves appear to be fundamental for the survival and function of cancer stem cells. These results create new possibilities for cancer treatment using drugs that modify the communication between neurons and cancer stem cells. The researchers hope this opens unforeseen paths toward effective therapies against cancer.

The combination of advanced molecular and imaging tools and organ-on-a-chip technology offers an opportunity to reveal the hidden functions of neurons and their interactions with various stem cell types, in both healthy and pathological conditions.

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Stem Cells, Nerves Found to Interact in Cancer Progression - Pharmacy Times

Canine Stem Cell Therapy Market by Players, Types and Applications with In-Depth Research On Industry Size … – The Financial News Daily

The Canine Stem Cell Therapy Market 2020 Research report provides information regarding Canine Stem Cell Therapy market share, size, trends, growth, cost structure, capacity, revenue and forecast 2026. This report also includes the overall and comprehensive study of the Canine Stem Cell Therapy Market with all its aspects influencing the growth of the market. This report is exhaustive quantitative analyses of the Canine Stem Cell Therapy industry and provides data for making strategies to increase market growth and effectiveness.

Final Report will add the analysis of the impact of COVID-19 on this industry.

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The Canine Stem Cell Therapy market 2020 research provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Canine Stem Cell Therapy market research is provided for the international markets as well as development trends, competitive landscape analysis, and key regions development status. Canine Stem Cell Therapy Market Report is spread across 185 pages and provides exclusive vital statistics, data, information, trends and competitive landscape details in this niche sector.

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Market segmentation, by Product Types:

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With tables and figures helping analyse worldwide Global Canine Stem Cell Therapy market, this research provides key statistics on the state of the industry and is a valuable source of guidance and direction for companies and individuals interested in the market.

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1 Industry Overview of Canine Stem Cell Therapy2 Major Manufacturers Analysis of Canine Stem Cell Therapy3 Global Price, Sales and Revenue Analysis of Canine Stem Cell Therapy by Regions 5 Europe Sales and Revenue Analysis of Canine Stem Cell Therapy by Countries6 Asia Pacific Sales and Revenue Analysis of Canine Stem Cell Therapy by Countries7 Latin America Sales and Revenue Analysis of Canine Stem Cell Therapy by Countries8 Middle East & Africa Sales and Revenue Analysis of Canine Stem Cell Therapy by Countries9 Global Market Forecast of Canine Stem Cell Therapy by Regions, Countries, Manufacturers, Types and Applications10 Industry Chain Analysis of Canine Stem Cell Therapy11 New Project Investment Feasibility Analysis of Canine Stem Cell Therapy12 Conclusion of the Global Canine Stem Cell Therapy Industry Market Professional Survey 2020

Continued

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Canine Stem Cell Therapy Market by Players, Types and Applications with In-Depth Research On Industry Size ... - The Financial News Daily

Global Stem Cell Banking Storage Market 2019 Present Status and Future Opportunities by Major Companies Typs and Applications 2024 – Skyline Gazette

The report on the Global Stem Cell Banking Storage Market has been prepared after conducting a comprehensive research through a systematized methodology. These skills are useful for scrutinizing the market on the terms of outlined research guidelines. Mainly, global Stem Cell Banking Storage market research report covers all the information about the target audience, manufactures, vendors, research papers, products and many more.

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Keeping a focus on the overall market aspects, and perceptions, this report vastly covers profiles of the companies who have made it big in this particular field along with their sales data and other data. It also suggests the business models, innovations, growth and every information about the big manufacturers that will be present the future market estimates. Every market consists of set of manufacturers, vendors and consumers that gives a definition to the market, its each and every move, achievements. All these are the important subjects required to study the analysis of the global Stem Cell Banking Storage market. It also includes the major market conditions across the globe such as the product profit, price, production, capacity, demand, supply, as well as market growth structure. In addition, this report offers significant data through the SWOT analysis, investment return data, and investment feasibility analysis.

Top Companies Analysis:

CCBCCBRViaCordEsperiteVcanbioBoyalifeLifeCellCrioestaminalRMS RegrowCordlife GroupPBKM FamiCordcells4lifeBeikebiotechStemCyteCryo-cellCellsafe Biotech GroupPacifiCordAmericordKrioFamilycordCryo Stemcell

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Segmentation by Type:

Umbilical Cord Blood Stem CellEmbryonic Stem CellOther

Segmentation by Application:

Diseases TherapyHealthcare

Moreover, the report comprises the analysis of opportunities available in the Stem Cell Banking Storage market on the global level. It also includes the major market conditions across the globe such as the product profit, price, production, capacity, demand, supply, as well as market growth structure.The annual progression for the global Stem Cell Banking Storage market in different regions cannot always be listed down as it will keep changing, thus studying and reviewing markets occasionally becomes vital. In addition, the Stem Cell Banking Storage market report provides a detailed information about the key market players along with the strategies they implemented to gain market existence and develop themselves. The report includes precise market estimations depending on current market status and future market forecasts.

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Global Stem Cell Banking Storage Market 2019 Present Status and Future Opportunities by Major Companies Typs and Applications 2024 - Skyline Gazette

Induced Pluripotent Stem Cell Market: Analysis and In-depth study on market Size Trends, Emerging Growth Factors and Regional Forecast to 2028 -…

The global Induced Pluripotent Stem Cell market was valued at $XX million in 2019, and our analysts predict the global market size will reach $XX million by the end of 2025, growing at a CAGR of XX% between 2019 and 2025.

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This report studies the global Induced Pluripotent Stem Cell Market status and forecast, categorizes the global Induced Pluripotent Stem Cell Market size (value & volume), revenue (Million USD), product price by manufacturers, type, application, and region. Induced Pluripotent Stem Cell Market Report by Material, Application, and Geography-Global Forecast to 2024 is an expert and far-reaching research provide details regarding the worlds major provincial economic situations, Concentrating on the principle districts (North America, Europe, and Asia-Pacific) and the fundamental nations (United States, Germany, United Kingdom, Japan, South Korea, and China).

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Overview of the chapters analysing the global Induced Pluripotent Stem Cell Market in detail:

Chapter 1 details the information relating to Induced Pluripotent Stem Cell introduction, Scope of the product, market overview, Market risks, driving forces of the market, etc

Chapter 2 analyses the top manufacturers of the Induced Pluripotent Stem Cell Market by sales, revenue etc for the Forecast period 2019 to 2024

Chapter 3 throws light on the competition landscape amongst the top manufacturers based on sales, revenue, market share etc for the period 2019 to 2024.

Chapter 4 analyses the global market by regions and their market share, sales, revenue etc for the period 2019 to 2024.

Chapters 5 to 9 analyse the Induced Pluripotent Stem Cell regions with Induced Pluripotent Stem Cell countries based on market share, revenue, sales etc.

Chapter 10 and 11 contain the information regarding market basis types and application, sales market share, growth rate etc for forecast period 2019 to 2024.

Chapter 12 focuses on the market forecast for 2019 to 2024 for the Induced Pluripotent Stem Cell Market by regions, type and application, sales and revenue.

Chapter 13 to 15 contain the details related to sales channels, distributors, traders, dealers, research findings, research findings, and conclusion etc for the Induced Pluripotent Stem Cell Market.

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Induced Pluripotent Stem Cell Market: Analysis and In-depth study on market Size Trends, Emerging Growth Factors and Regional Forecast to 2028 -...

GoBroad Healthcare Group Commences Construction of its Research Hospital in Beijing – PRNewswire

The 100,000-square meter, 500-bed, GoBroad Research Hospital, upon completion, will provide a cutting-edge space designed for the implementation of translational medicine research and reduce the time to market for new drugs through international relationships, collaborative research, personalized clinical services, and technology empowerment.

The facility will provide pharmaceutical producers with a full-cycle service system from early clinical trials to drug registration and availability, effectively solving the bottlenecks they face, including long cycles and the high cost of clinical research.

The research-oriented facility is scheduled to come online in 2023 following three years of construction.

Despite the severe challenges brought about by the COVID-19 epidemic, it took only 124 days for GoBroad Healthcare Groupto go from the signing the strategic cooperation framework agreement to construction, including all the necessary procedures associated with planning, land acquisition, government approval and development.

Building a research-oriented innovative medical group

GoBroadResearch Hospital aims to become a research-oriented international-grade healthcare facility centred on translational science.

The hospital will addressthe unmet needsin the industry, including a lack of institutional capability for conducting clinical trials and investment in resources, such as experts and hospital beds.

The investment into the GoBroadResearch Hospital project marks the completion of Hillhouse Capital's closed-loop investment in the pharmaceutical and healthcare sectors. With Hillhouse Capital's extensive portfolio in the sector, GoBroadHealthcareGroupis uniquely positioned to create an innovative drug ecosystem. It has become a pioneer in terms of promoting industrial transformation.

In 2019, GoBroad Healthcare Group established the Industrial Transformation Research Institute, bringing global top scientific research institutions and clinical specialists together to create a collaborative R&D across multiple locations.

GoBroad Healthcare Group operates five research-oriented medical institutions and a phase I ward lead by specialists in the fields of medical diagnosis, treatment and research that can support the development of the hospital. In addition, the company's team of clinical professionals has, in the aggregate, conducted over a hundred trials.

The project represents the latest investment by GoBroad Healthcare Group in the research hospital field following the opening of Shanghai Artemed Hospital in mid-2019.

GoBroad Healthcare is a medical platform wholly owned by Hillhouse Capital. The commencement of construction of the new hospital is an important step in the company's strategy to transform itself into a research-oriented medical group driven by innovation. Hillhouse Capital and GoBroad Healthcare Group plan to create a medical service and technological innovation platform integrating production and research by taking full advantage of their respective strengths in biopharmaceutical investment and the management of research-oriented healthcare industry translational projects, as well as in global resources and capital investments in the sector.

About GoBroad Healthcare Group

GoBroad Healthcare Group is dedicated to creating a medical service and technological innovation platform integrating pharmaceutical production and research, with a focus on blood diseases and tumors, among other medical fields. Its medical ecosystem covers the entire hospital supply chain. From clinical laboratories, a medical imaging facility, and big data centers to biotherapy Research and treatment. Currently, the group has three homoeopathy R&D centers and five hospitals in Beijing, Shanghai and Guangzhou, with a total of 800 beds and 88 hematopoietic stem cell transplantation wards.

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GoBroad Healthcare Group Commences Construction of its Research Hospital in Beijing - PRNewswire

Cell Banking Outsourcing Market With Economic Growth And Five Forces Analysis By 2021 – Lake Shore Gazette

A cell bank refers to a facility that store cells derived from various body fluids and organ tissue for future needs. The bank store the cells with detailed characterization of the cell line hence decrease the chances of cross contamination. Cell banking outsourcing industry involves collection, storage, characterization, and testing of cells, cell lines, and tissues. Cell banks provide cells, cell lines, and tissues for R&D, production of biopharmaceuticals with maximum effectiveness and minimal adverse events. The process for storage of cells includes first proliferation of cells that multiplied in large number of identical cells and then stored into cryovials for future use. Cells mainly used in the regenerative medicine production. Increasing demand of stem cell therapies and number of cell banks expected to boost the global market.

Global cell banking outsourcing market segmented based on bank type, cell type, phase, and geography. Based on bank type market is further segmented into master cell banking, working cell banking, and viral cell banking. Cell type segment further divided based on stem cell banking and non-stem cell banking. Stem cell banking includes dental, adult, cord, embryonic, and IPS stem cell banking.

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Based on phase, the global cell banking outsourcing market segmented into preparation, storage, testing, and characterization. Geographically, market divided into North America, Europe, Asia Pacific, Latin America, and Middle East Africa. By considering bank type master cell banking accounted largest share owing to longer duration of preservation that would attract the researcher. Stem cell banking accounted larger share than non-stem cell banking due to lower risk of contamination.

In stem cell banking cord stem cell banking accounted larger share by revenue in 2014 due to increasing number of cord blood banks, and services globally. Additionally, donor convenience, immediate availability, lower risk of viral contamination is major driving factors for cord stem cell banking. In bank phase, segment storage phase accounted largest share and expected to maintain its share due to development of sophisticated preservation technologies such as cryopreservation technique. Geographically, North America accounted largest share due to high number of ongoing research projects. However, Asia Pacific expected to show significant growth during forecast period owing to supportive government initiatives coupled with increasing awareness about cell therapies.

The global cell banking outsourcing market is witnessing lucrative growth during forecast period due to increased research in cell line development owing to rise in incidence of infectious chronic disorder, and cancer. Additionally, development of advanced preservation techniques, increasing adoption to the stem cell therapies, rise in cell bank facilities across globe, and moving focus of researcher towards stem cell therapies would drive the market. However, high cost of therapies, availability of right donors, and legal and changing ethical issues during collection across the globe are major restraint of the market. Risk associated with cell line banking is contamination of cell lines by manual errors or environmental conditions hence care should be taken during storing and handling of cells.

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Major player in cell banking outsourcing market include BioOutsource (Sartorious), BioReliance, BSL Bioservice, Charles River Laboratories, Cleancells, CordLife, Covance, Cryobanks International India, Cryo-Cell International Inc., GlobalStem Inc., Goodwin Biotechnology Inc., LifeCell International Pvt. Ltd., and Lonza. Additionally, PXTherapeutics SA, Reliance Life Sciences, SGS Life Sciences, Texcell, Toxikon Corporation, Tran-Scell Biologics, Pvt. Ltd., and Wuxi Apptec are other companies in global cell banking outsourcing market.

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Cell Banking Outsourcing Market With Economic Growth And Five Forces Analysis By 2021 - Lake Shore Gazette

Q&A: Covid-19 and impact on people with cancer – The Irish Times

Why is Covid-19 a big risk for people with cancer?

The Covid-19 pandemic is immensely challenging and distressing for people with cancer, but also for those not sure if they have the disease not to mention their families.

This is greatly added to because cancer patients undergoing treatment often have weakened immune systems. Evidence from China shows their vulnerability is heightened if they become infected by coronavirus. While those with cancer have a heightened risk of death in such circumstances, it should be stressed the great majority survive.

People with weakened immune systems are at greater risk of getting infections such as the common cold, flu and pneumonia as well as Covid-19. That is why people with cancer are classified in the most at-risk group and subjected to severe restrictions.

The short answer is yes. The Irish Cancer Society (ICS) outlines key categories that must cocoon, including people who are being treated with chemotherapy, those undergoing radical radiotherapy for lung cancer and patients with cancers of the blood or bone marrow such as leukaemia, lymphoma or myeloma at any stage of treatment.

It includes people having immunotherapy or other antibody treatments for cancer and those undergoing targeted cancer treatments which can affect the immune system. People with bone-marrow or stem-cell transplants in the past six months, or who are still taking immunosuppression drugs, are also included.

Those who have had cancer in the past are advised to take precautions, factoring in their age and if they have other conditions.

The Irish health system has had to radically redirect services to brace itself for a surge in Covid-19 cases. This had huge implications for those with cancer whose treatment has in many instances been curtailed or postponed.

That reality was summarised by oncologist Prof John Crown: Many cancer operations and clinic appointments are being cancelled or postponed. Radiotherapy services are being scaled back. Drug treatments are being delayed, discontinued or altered. Patients who have just received the distressing news of a cancer diagnosis have on occasions been left wondering when their own treatment can start. Others who are already on treatment wonder if it is safe to continue.

According to the World Health Organisation, risk may be higher for those with blood cancers like leukaemia as opposed to solid tumours ie breast, prostate or pancreatic cancer.

Some specialist services are no longer able to process referrals from GP patients with lumps and other symptoms suggestive of potential cancer. Delayed diagnosis and treatment adds to risk but many cancers advance slowly.

The bottom line is cancer patients must avoid infection and cocooning is best to ensure this doesnt happen.

Unlike Italy, quality cancer services and diagnostics are still in place in Ireland, according to ICS head of research Dr Robert OConnor. Patients with active cancers are being seen and getting treatment once Covid-19 risk is minimised.

Oncologists, however, have to weigh up the benefits of treatment against the risk of what might happen if someone gets the virus during that treatment.

For this reason, certain scans, procedures, treatments or surgery may be postponed. Everyones cancer treatment is individual and decisions on treatment are being made on a case-by-case basis.

This is complicated by having a cardiovascular condition; diabetes or an autoimmune disease. Some difficult conversations have to be had on additional adjuvant treatments and on palliative care.

They are advised to contact their GP, who often can provide assurance symptoms dont indicate cancer. Those with overt symptoms are getting treatment.

The ICS has set up remote counselling for adults and children with cancer and their carers. It is targeted at those who cannot access face-to-face counselling due to coronavirus restrictions. Its available through its Nurseline service (Freephone 1800-200700) or via email cancernurseline@irishcancer.ieIt also offers help for patients who may be finished treatment but unsure how Covid-19 affects them.

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Q&A: Covid-19 and impact on people with cancer - The Irish Times

COVID-19 and Cancer: What You Need to Know – Everyday Health

The outbreak of the novel coronavirus COVID-19 has officially become a pandemic, according to the World Health Organization. The new classification emphasizes the likelihood that the disease will be a problem in your community. If youre being treated for cancer, what should you do to protect yourself from this coronavirus? We asked five experts to answer the most pressing questions.

Which cancer patients are at highest risk for infection or complications?

Those most vulnerable are people with blood cancers, such as leukemia or lymphoma, and those receiving heavy-duty chemotherapy or undergoing bone marrow or stem cell transplants, according to Brandon Hayes-Lattin, MD, medical director of the division of hematology and medical oncology at Oregon Health and Science University in Portland.

There is a bit of clinical judgment in figuring out which patients are in the highest risk category, Dr. Hayes-Lattin says. Those with low white blood cell counts are particularly high risk, whereas patients who have a history of cancer or are on endocrine or targeted therapies are not.

Its best to talk with your oncologist or medical team about your particular risk since it depends on your cancer type and treatment type. For some individuals, the cancer and treatment together are a double whammy.

Those with leukemia and lymphomas are already high risk because those diseases are immunocompromising, and then were hitting them with the heaviest duty chemotherapy we have, explains Gregory Poland, MD, a professor of medicine at the Mayo Clinic in Rochester, Minnesota, and director of the Mayo Clinic's vaccine research group.

Your risk also depends on factors besides your cancer and treatment types, explains David Quinn, MD, medical director of the University of Southern California Norris Comprehensive Cancer Center and an associate professor of medicine at Keck Medicine of USC in Los Angeles.

The other issue is what the other health issues of our cancer patients are, Dr. Quinn says. Those who smoke or have lung conditions such as COPD have greater risk for complications, he says. Older adults, especially those who are already medically frail or living in skilled nursing facilities, are also higher risk.

RELATED: What People With Heart Disease Need to Know About COVID-19

What should patients be doing to protect themselves from the virus?

By this time, wash your hands sounds like a broken record, but it really is the single most important piece of advice public health experts have to offer. The trick is doing it well. Dr. Poland recommends a video in which he teaches late night personality Jimmy Kimmel how to wash your hands correctly and many on set were surprised how poorly they had cleaned their hands.

The key points are to use warm water and soap and to scrub all of your hands and lower arms for at least 20 seconds before rinsing.

In addition, avoiding crowds, large gatherings, and sick people in general is an important strategy, Hayes-Lattin says.

The other piece of advice for everyone, including cancer patients, is staying healthy, getting good sleep, maintaining good nutrition, maintaining exercise, and avoiding smoking, Hayes-Lattin says. The healthier your body is to start with, the stronger it will be if it needs to fight an infection.

What about hand sanitizer?

Nothing can replace the benefits of washing hands, but hand sanitizer is a distant second best, Poland says. If your hands are visibly soiled, or if you actually have mucus on them, hand sanitizer cannot penetrate that and neutralize the virus, he says. Plus, people dont use hand sanitizer properly and often dont use enough of it.

But if you dont have access to soap and water, hand sanitizer containing at least 60 percent alcohol offers some protection if you use a half dollarsized amountnot just a dime-sized amountand ensure it covers all areas of your hands and fingers.

RELATED: Can You Get Coronavirus From Your Dog? Plus More Pet-Related Questions Answered

What about wearing a mask?

While the average healthy person does not benefit from a face mask and this does not appear to be an airborne virus (the mask may merely help protect you from droplets from other peoples coughs and sneezes) wearing a standard surgical mask while out and about can serve two purposes for high-risk patients, Poland says. First, it can serve as a behavioral cue to remind you to practice good hygiene and to distance yourself from others. Others also may be more likely to stay away from you while youre wearing a mask.

Ideally, though, for somebody who is significantly immunosuppressed during a pandemic, its a good idea to stay indoors and away from people, Poland says. If they are older in age or have other conditions, theyre layering risk upon risk.

And what about the N95 respirators you may have read about? All the experts interviewed recommended against it. You cant buy an N95 mask off the shelf and fit it properly yourself if you dont have training, Poland says.

What should friends, family and household members do to protect you?

Number one, they should all get their flu shots if they havent already done so, Poland says. Next, all household members and visitors need to practice respiratory etiquette: sneezing or coughing into a tissue or the crook of their arm and then immediately washing their hands.

Third, if possible, the immune-compromised person should have their own room with an open window, Poland says. Finally, any frequently touched surfaces, such as doorknobs or countertops, should be regularly wiped down.

An additional strategy is that you dont want people coming into the home who are sick in any way or who havent gotten a flu vaccine, Poland says. And as hard as it may be, you want to maintain a no-handshake, no-hugging, no-kissing, policy, he says.

If children live in the home, theres no getting around the fact that they are more likely to transmit any infections, especially ones they bring home from school, Poland says. Although COVID-19 does not seem to affect children as much as adults, scientists do not yet know if children transmit it as much as adults. But children can still bring home other illnesses, particularly influenza, so its helpful to take the time to regularly teach and reteach them proper hand-washing and respiratory etiquette.

If no children live with you, avoiding visits might be worth considering. These are value judgements, Poland says, but in a patient who just had a heavy dose of chemotherapy, I probably wouldnt let, for example, grandkids into the house during [the next two weeks] because of the risk.

RELATED: Life With MS in the Time of COVID-19

What should I do if I develop respiratory symptoms?

For very high-risk patients, any infection, COVID-19 or otherwise, may be life-threatening, so Poland recommends these patients take their temperature every day. If you notice even a mild fever, thats a reason to call your doctor and be evaluated, he says.

Developing a dry cough is another red flag, Quinn says. Anyone who has a fever or cough should put on a mask to protect others and call their primary care office if they suspect they might have a respiratory illness.

Do not just show up at a cancer center, Quinn says, because you risk exposing others there to your illness. If youre severely ill, you may need to go to the emergency department or call for an ambulance, but the majority of coronavirus patients, including those with cancer, can be managed at home, he says.

Do I need to avoid all travel and only stay at home?

Whether you travel or go out into the community depends on several factors, including your own risk level and possibly where you live.

If youre in Boston or Seattle, you need more layers of protection than you do in [a small town in] Kansas because your risk is quantifiably higher, Poland says. Your risk is also higher if you go to mass gatherings or anywhere people touch many surfaces.

Its difficult to tell people to stay completely shut in at home and keep out all visitors, and only extremely high-risk patients likely need to consider doing so. You should talk to your oncologist and medical team about whether you need such isolation.

RELATED: 4 Misconceptions About the Coronavirus

Should I continue my cancer treatment?

Yes. If you have appointments, keep them, Quinn says. However, if youre sick or have respiratory symptoms, call your oncologist or treatment centers office first and notify them of your symptoms so they can give you instructions and be prepared for your visit. Quinn says his clinic, for example, is using extra wipes on chemotherapy chairs between patients and paying extra attention to surfaces such as door handles that get touched more often.

Where can people go for the best information, to learn more, or monitor the situation?

The experts interviewed recommended the following sources: The Centers for Disease Control and Prevention page on the coronavirus, the patient site Cancer.net from the American Society of Clinical Oncology, the pages for your local county and state health department, and the World Health Organization.

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COVID-19 and Cancer: What You Need to Know - Everyday Health

Working Together Working Together: Indianapolis couple offers Airbnb to healthcare workers Nicole Griffin 1:41 PM – WRTV Indianapolis

Working Together is a new WRTV initiative that focuses on telling impactful stories highlighting the wide range of cultures, areas and people that make central Indiana the place that it is. Through our Working Together initiative, we will share the stories of our communities and carry their voices forward. Were Working for You by Working Together.

INDIANAPOLIS The coronavirus outbreak is causing a major impact on those who host Airbnbs. What could have been an busy month is ending with virtually no business for an Indianapolis couple.

Jacks Von Liria and his husband Michael Hoster estimate they are out around $2,000 this month, so instead of letting their Holy Cross apartment sit empty, they wrote a Facebook post saying they know there are doctors and nurses that are busy saving lives and they want to offer their apartment to any healthcare worker who needs a place to stay for free.

"The business has been wiped out because there was no traveling no events, no restaurants," Von Liria said. "The stories they were telling us we're so heartbreaking we got overwhelmed. There are nurses sleeping in their cars because they can't go see their children."

Alison Isenhour, an X-ray technician for IU Health, said on Tuesday she was informed she was exposed to a person who had contact with a positive coronavirus patient. Her son, Adam, has leukemia and had a stem cell transplant in June 2019, and she has been advised to not go home.

"I was planning on just staying at the hospital for the weekend," Isenhour said. "It was nice to be able to get out and go somewhere else and decompress. I can't mess that up if I were to go home and said they were to happen to him whether it was my fault or not I would never let myself let it down.

While her husbands takes care of the kids, Isenhour now has a safe place to spend the weekend before returning to work Monday.

"I'm really glad that others will be able to have this moment as well. It's needed. I was tired when I got here yesterday. My legs hurt, I was mentally worn out, I was just fried from being there all week," Isenhour said.

Airbnb is currently helping 100,000 COVID-19 responders by connecting healthcare providers, relief workers and first responders with clean, convenient places to stay.

"Especially all the stories we've heard and knowing they need out there," Hoster said. "I'm hoping someone will watch this and want to help, too."

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Working Together Working Together: Indianapolis couple offers Airbnb to healthcare workers Nicole Griffin 1:41 PM - WRTV Indianapolis