Category Archives: Stell Cell Research


Stem Cell Characterization Kits Market Research Report and Outlook by 2018 to 2026 – Owned

Fact.MR, in a recently published report, offers valuable insights related to the key factors that are projected to influence the growth of the Stem Cell Characterization Kits market during the forecast period, 2019-2029. The current market trends, vast growth opportunities in different regional markets, market drivers, and restraining factors are thoroughly analyzed in the report on the Stem Cell Characterization Kits market.

The data enclosed in the report such as the Year-on-Year (Y-o-Y) market growth, supply chain analysis, value chain analysis and more will enable readers to assess the quantitative aspects of the Stem Cell Characterization Kits market with clarity. The presented study is a vital asset for stakeholders, investors, and market players involved in the Stem Cell Characterization Kits market who can leverage the information in the report to develop effective business strategies.

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Key Findings of the Report:

Stem Cell Characterization Kits Market Segmentation

The report on the Stem Cell Characterization Kits market provides vital analytical insights related to the key market segments including, region, application, and end-use. Further, the report discusses the current and future prospects of each market segment along with informative graphs, tables, and figures.

Segments of the Stem Cell Characterization Kits market assessed in the report:

Competitive landscape

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Stem Cell Characterization Kits Market Research Report and Outlook by 2018 to 2026 - Owned

Cell Expansion Market Set to Surpass US$XX Million by the end of 2017 2025 – Owned

Evaluation of the Global Cell Expansion Market

The presented study maps the growth trajectory of the global Cell Expansion market by thoroughly assessing the various factors that are expected to influence the future prospects of the Cell Expansion market. According to the report published by PMR, the Cell Expansion market is poised to attain a value of ~US$ XX Mn/Bn by the end of 2029 with a CAGR growth of ~XX% during the forecast period (2019-2029).

A complete evaluation of the trends, market drivers, opportunities, and challenges faced by market players operating in the Cell Expansion market is provided in the report. Further, an overview and introduction of the Cell Expansion market is included to ensure that the readers have a seamless experience while going through the contents of the report.

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Critical insights included in the report:

Competitive Outlook

The competitive outlook assessment provides an in-depth understanding related to the business proceeding of top-tier market players in the global Cell Expansion market. The product portfolio, sales strategy, marketing & promotional strategy, and sales footprint of each market player is scrutinized thoroughly in the report. Some of the leading players evaluated in the report include:

The report segments the global Cell Expansion market on the basis of region, product type, and end use.

Key Players

The major players in cell expansion market include Beckman Coulter, Inc, Thermo Fisher Scientific, Inc., Becton, Dickinson and Company, Terumo BCT, Inc., Corning, Inc., Stemcell Technologies, Inc., GE Healthcare, Merck KGaA (Sigma-Aldrich Co. LLC), Lonza, Miltenyi Biotec among others. Companies have several ongoing research for cell-based therapies and stem cell-based therapies; it has been found that companies are in the development of new products and systems which ensure market growth during the forecast period. Only a few manufacturing companies are involved in the manufacturing of cell expansion instruments.

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Regional Analysis

The market scenario in each region along with a comprehensive assessment of the micro and macro-economic factors that are forecasted to impact the market growth in these regions is included in the report.

End Use Assessment

The market study offers accurate and in-depth analysis of the various end uses of the Cell Expansion along with a yearly comparison of the market share and revenue growth of each end use.

Important queries addressed in the report:

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Cell Expansion Market Set to Surpass US$XX Million by the end of 2017 2025 - Owned

Global Multiple Myeloma Therapeutics Market 2020 | With Top Growing Companies & Coronavirus (COVID-19) Impact Analysis | Amgene, Inc., Celgene…

Global Multiple Myeloma Therapeutics Market 2020-2026 Global Industry Size, Supply Analysis, Price Analysis, Consumption and Production, Supplier and Cost Structure Analysis

The latest report on the globalMultiple Myeloma Therapeutics marketpublished by theMarket Research Storeincludes an exhaustive research details about the Multiple Myeloma Therapeutics market incorporating the global industrial conditions, value chain structure, market size, forecast details, along with other minute details about the market. In this latest report, the research analysts have tried to cover the current market scenario owing to the outbreak of the pandemic. Each and every market on the global platform has been affected due to COVID-19. Several big changes have been observed in the market conditions which all have been included in the report. Based on this the forecast analysis and future opportunities of the Multiple Myeloma Therapeutics market has been predicted.

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The Multiple Myeloma Therapeutics market has been categorized into{Drugs, Radiation, Stem Cell Transplant, Other Supportive Treatments}; {Hospitals, Clinics, Others}. The regional prominence of the market has been considered for regions such as North America, Europe, Latin America, Asia Pacific, and the Middle East and Africa. All the details regarding the market segments have been depicted through both qualitative and quantitative format. With the help of figures and tables the information has been represented for easy and clear understanding of the Multiple Myeloma Therapeutics market.

The report basically gives information about the Multiple Myeloma Therapeutics market trends, growth factors, limitations, opportunities, challenges, future forecasts, and details about all the key market players. Some of the major industry players that are listed within the report includeAmgene, Inc., Celgene Corporation, Juno Therapeutics, Bristol-Myers Squibb, Novartis AG, Kesios Therapeutics Limited, Bristol-Myers Squibb Company, Genzyme Corporation, Millennium Pharmaceuticals, Janssen Biotech, Inc..

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Multiple Myeloma Therapeutics Market Values:

The Multiple Myeloma Therapeutics market was valued at USD XX Million in 2019 and is estimated to have a CAGR of around XX% during the forecast period to reach USD XX million by 2026.

Regional Analysis:

North America (USA, Canada, and Mexico) Europe (Germany, France, the UK, and Rest of Europe) Asia Pacific (China, Japan, India, and Rest of Asia Pacific) Latin America (Brazil and Rest of Latin America) Middle East & Africa (Saudi Arabia, the UAE, South Africa, and Rest of Middle East & Africa)

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Global Multiple Myeloma Therapeutics Market 2020 | With Top Growing Companies & Coronavirus (COVID-19) Impact Analysis | Amgene, Inc., Celgene...

Biotechnology Reagents Market Analysis and Forecast by Rapid Growth Rate 2020 Value Share Analysis by Regions, Industry Size, Key Insights till 2024 -…

Waters Corp.

Report Highlights:

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Key Market Trends:

Chromatography is Expected to Hold Significant Market Share in the Type of Analytical Reagents

Chromatography is a separation technique mainly used in drug discovery to validate the specificity, sensitivity, and purity of drugs. Chromatographic procedures have been largely used for analytical procedures and methods validation for drugs and biologics. Chromatographic techniques provide accurate results to validate characters, such as specificity, linearity, accuracy, precision, range, quantitation limit, and detection limit of various drugs. Chromatography reagents are used in a variety of applications, including high-performance liquid chromatography (HPLC), ion chromatography, flash chromatography, and complexometric titration. These reagents provide more precise, cost-effective separations, superior reproducibility, and accurate results in all forms of analytical chromatography. Since the chromatography techniques are well-established across the world, the demand for their reagents are consistently high for various pathological and academic purposes.

North America Dominates the Market and is Expected to Dominate in the Forecast Period

North America dominates the biotechnology reagents market and incurs the highest expenditure for global R&D. The United States accounted for the largest share in 2018. The North American segment is on a rise, due to various ongoing research in biological sciences, considerable investments by various biotechnology companies, and the consistently increasing utilization of biotechnology reagents in the market. Owing to the ongoing research and outsourcing activities in the field of life science, Asia-Pacific also has lucrative opportunities for growth over the forecast period.

The Report Covers:

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Detailed TOC of Biotechnology Reagents Market Report 2020-2024:

1 INTRODUCTION 1.1 Study Deliverables 1.2 Study Assumptions 1.3 Scope of the Study

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS 4.1 Market Overview 4.2 Market Drivers 4.2.1 High Research and Development Expenditure by Biotechnology Companies 4.2.2 Increasing Interest in Stem Cell Research 4.2.3 Rise in Number of Biotechnology Firms 4.3 Market Restraints 4.3.1 Stringent Government Regulations for Approval of Reagents 4.3.2 High Price of Biopharmaceuticals 4.4 Porters Five Force Analysis 4.4.1 Threat of New Entrants 4.4.2 Bargaining Power of Buyers/Consumers 4.4.3 Bargaining Power of Suppliers 4.4.4 Threat of Substitute Products 4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION 5.1 Technology 5.1.1 Life Science Reagents 5.1.1.1 PCR 5.1.1.2 Cell Culture 5.1.1.3 Hematology 5.1.1.4 In-vitro Diagnostics 5.1.1.5 Others 5.1.2 Analytical Reagents 5.1.2.1 Chromatography 5.1.2.2 Mass Spectrometry 5.1.2.3 Electrophoresis 5.1.2.4 Flow Cytometry 5.1.2.5 Other Analytical Reagentss 5.2 Application 5.2.1 Protein Synthesis and Purification 5.2.2 Gene Expression 5.2.3 DNA and RNA Analysis 5.2.4 Drug Testing 5.2.5 Other Applications 5.3 Geography 5.3.1 North America 5.3.1.1 United States 5.3.1.2 Canada 5.3.1.3 Mexico 5.3.2 Europe 5.3.2.1 Germany 5.3.2.2 United Kingdom 5.3.2.3 France 5.3.2.4 Italy 5.3.2.5 Spain 5.3.2.6 Rest of Europe 5.3.3 Asia-Pacific 5.3.3.1 China 5.3.3.2 Japan 5.3.3.3 India 5.3.3.4 Australia 5.3.3.5 South Korea 5.3.3.6 Rest of Asia-Pacific 5.3.4 Middle East & Africa 5.3.4.1 GCC 5.3.4.2 South Africa 5.3.4.3 Rest of Middle East & Africa 5.3.5 South America 5.3.5.1 Brazil 5.3.5.2 Argentina 5.3.5.3 Rest of South America

6 COMPETITIVE LANDSCAPE 6.1 Company Profiles 6.1.1 Abbott Laboratories 6.1.2 Agilent Technologies 6.1.3 Beckman Coulter 6.1.4 Becton Dickinson & Company 6.1.5 Bio-Rad Laboratories 6.1.6 GE Healthcare 6.1.7 Siemens Healthcare 6.1.8 Sigma Aldrich Corporation 6.1.9 Thermo Fisher Scientific Inc. 6.1.10 Waters Corp.

7 MARKET OPPORTUNITIES AND FUTURE TRENDS

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Biotechnology Reagents Market Analysis and Forecast by Rapid Growth Rate 2020 Value Share Analysis by Regions, Industry Size, Key Insights till 2024 -...

Personalized Cell Therapies Market to Witness Astonishing Growth by 2025 – Owned

The selective research report on the GlobalPersonalized Cell Therapies Market2020 analyzes the market in detail alongside concentrating on huge market elements for the key players working in the market. Worldwide Personalized Cell Therapies Market Industry research report offers granulated at this point top to bottom examination of income share, advertise portions, income gauges and different areas over the globe.

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This report contains a total item outline and its extension in the market to characterize the key terms and give the customers a comprehensive thought of the market and its propensity. It completely assesses the worldwide Personalized Cell Therapies Market advertise with alternate points of view to give a nitty gritty, instructive, and precise investigation of local development, rivalry, showcase division, and other significant viewpoints.

The following players are covered in this report are:

PCT Cell Therapy Services, LLC (U.S) S. Stem Cell, Inc. (U.S) Bellicum Pharmaceuticals, Inc. (U.S) Saneron CCEL Therapeutics, Inc. (U.S) StemGenex (U.S) Vericel Corporation.(U.S) Cytori Therapeutics Inc.(U.S.) MolMed S.p.A. (Italy)

Personalized Cell Therapies Market segmentation by Types:

Hematopoietic Stem Cell Skeletal Muscle Stem Cell Mesenchymal Stem Cells Lymphocytes Others

Applications can be segmented as follows:

Cardiovascular Disorders Diabetes Neurological Disorders Cancer Others

The statistical surveying insight report on title Global Personalized Cell Therapies Market gives stick guide examination toward changing focused elements and a forward-looking viewpoint on changed variables driving or limiting industry development. The Personalized Cell Therapies Market industry report gives vital and helper information which is spoken to in pie-graphs, tables, methodical outline, and item charts.

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The Personalized Cell Therapies Market Report likewise decide the economic situations including the item value, particular, inquire about approach, money related and specialized subtleties which will extend the market activities. The Market research report gives the most recent industry information and industry future patterns, enabling you to distinguish the items and end clients driving income development and gainfulness.

Key Features of the Report: The report provides granular level information about the market size, regional market share, historic market (2014-2018) and forecast (2019-2025)

The report covers in-detail insights about the competitors overview, company share analysis, key market developments, and their key strategies

The report outlines drivers, restraints, unmet needs, and trends that are currently affecting the market

The report tracks recent innovations, key developments and startups details that are actively working in the market

The report provides plethora of information about market entry strategies, regulatory framework and reimbursement scenario

The report analyses the impact of socio-political environment through PESTLE Analysis and competition through Porters Five Force Analysis in addition to recent technology advancements and innovations in the market

About Us: Precision Business Insights is one of the leading market research and management consulting firm, run by a group of seasoned and highly dynamic market research professionals with a strong zeal to offer high-quality insights. We at Precision Business Insights are passionate about market research and love to do the things in an innovative way. Our team is a big asset for us and great differentiating factor. Our company motto is to address client requirements in the best possible way and want to be a part of our client success. We have a large pool of industry experts and consultants served a wide array of clients across different verticals. Relentless quest and continuous endeavor enable us to make new strides in market research and business consulting arena.

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Personalized Cell Therapies Market to Witness Astonishing Growth by 2025 - Owned

Why Superman 5 With Christopher Reeve Never Happened – Screen Rant

Despite Superman IV: The Quest for Peace's failure, there was a hope that Christopher Reeve would return for Superman V. Here's why it didn't happen.

Superman V never happened, and there are ample reasons why Christopher Reeve never performed as the Man of Steel again after the failure of 1987's Superman IV: The Quest for Peace. Christopher Reeve played Superman for a decade, starting with Richard Donner's 1978 Superman: The Movie and continuing on with Richard Lester's Superman II and Superman III. For a generation of fans, Reeve's earnest Superman is the definitive version and he remains the standard by which all other actors who have played the Man of Steel are judged.

The first two Superman movies, which were produced by Alexander and Ilya Salkind, were global blockbusters. Donner's original film innovated the special effects technology that made audiences believe Superman could really fly, and the first two films are wildlyimaginative and heartfelt adventures that pioneered the modern superhero movie. Unfortunately, Superman III, which co-starred the comedian Richard Pryor, was a disappointment; it was made with a slashed budget, grossed less than its predecessors, and the third film received mixed reviews from critics and audiences, despite novel ideas like an evil Superman fighting his good side, Clark Kent. After Superman III and the subsequent failure of the Supergirl spinoff in 1984 (which Reeve refused to appear in), the Salkinds decided the Superman movies had run their course and they sold the rights to Menahem Golan and Yoram Globus of Cannon Films.

Related: What Superman Returns 2 Was Supposed To Be About (& Why It Didn't Happen)

However, the Cannon Films-produced Superman IV: The Quest for Peace was a disaster. Cannon had numerous films under production and attempted to make Superman IV for even less money than Superman III, shortchanging everything from the sets to the obviously sub-par visual effects. Despite a socially-relevant story partly conceived by Reeve where Superman tries to rid the world of nuclear weapons, and the return of Gene Hackman as Lex Luthor, Superman IV was an embarrassment to everyone involved and grossed a paltry $36-million worldwide. With Superman IV crashing and burning, there was virtually no chance Reeve would agree to return for Superman V.

Despite their failure, Cannon Films did intend to make Superman V at one point and earmarked Reeve to return as the Man of Steel. Cannon's plan was to take an even cheaper route and cobble together 45 minutes of unused footage from Superman IV as the basis for a fifth movie. However, nothing came of it, and Cannon, which was in the red after numerous cinematic failures, folded in the early 1990s. The movie rights to Superman reverted back to the Salkinds, but they created a Superboy TV series instead of a movie.

Still, in 1991, screenwriter Cary Bates pitched an idea for Superman V to Alexander and Ilya Salkind, which would star Christopher Reeve once more. Bates' plan was to ignore Superman III and IV (something Bryan Singer also chose to do when he directed Superman Returns in 2006) and pit the Man of Steel against Brainiac in the Bottled City of Kandor. But at this point in the early '90s, the Salkinds were producing Christopher Columbus: The Discovery, which ran massively overbudget and ultimately lost the father-son producing team $40-million. The Salkinds quit the movie business afterward and the Superman movie rights reverted to Warner Bros. After Superman IV failed in 1987, it would take 19 years for the Man of Steel to return to the big screen in Superman Returns,despite an infamous attempt by Warners to make Superman Lives starring Nicolas Cage and directed by Tim Burton.

In 1995, Christopher Reeve suffered a tragic accident when he was thrown from his horse during an equestrian competition. The accident left Reeve a quadriplegic, although he heroically persevered. Following his rehabilitation, Reeve became a champion for stem cell research, spinal cord research, and people with disabilities, establishing the Christopher Reeve Foundation (which is now the Christopher and Dana Reeve Foundation). Reeve also returned to acting and he even appeared in season 2 of Smallville, where he passed the torch to the small screen's newest Man of Steel, Tom Welling. Christopher Reeve died on October 10, 2004, but the final years of his life proved the real-life man was more heroic than appearing in Superman V would ever allow him to be.

Next:Kingdom Come Superman Becomes [SPOILER] At The End Of Crisis on Infinite Earths

Scott Disick 'Flirting' with Kourtney Kardashian After Sofia Richie Split

John has been writing about what he likes - movies, TV, comics, etc. - for over a decade. He's worked in movies and rubbed shoulders with big names but somehow forgot to ask for money a lot of the time - hence, he is happy to be with Screen Rant. John can be found @BackoftheHead, counts a Black Canary and an Agent of S.H.I.E.L.D. among his friends, believes (correctly) that Superman is stronger than the Hulk, and he is a friend to all talking gorillas.

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Why Superman 5 With Christopher Reeve Never Happened - Screen Rant

Research On Global Stem Cell Cartilage Regeneration Market (impact of COVID-19), Analysis, Overview, Growth Forecast, Top key players Anika…

Global Stem Cell Cartilage Regeneration Market 2020 Research Report

The Global Stem Cell Cartilage Regeneration Market 2020 Research Report is a professional and in-depth study on the current state of Stem Cell Cartilage Regeneration Market.

This report provides pinpoint analysis for changing competitive dynamics. It offers a forward-looking perspective on different factors driving or limiting market growth. It provides a five-year forecast assessed on the basis of how they Stem Cell Cartilage Regeneration Market is predicted to grow. It helps in understanding the key product segments and their future and helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments.

The key manufacturers covered in this report are:Anika Therapeutics,Zimmer Biomet,BioTissue Technologies,DePuy (Johnson & Johnson),Genzyme,CellGenix,EMD Serono,Sanofi Aventis,Smith & Nephew.

The final report will add the analysis of the Impact of Covid-19 in this report Stem Cell Cartilage Regeneration industry.

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Key questions answered in the report include:

What will the market size and the growth rate be in 2027?

What are the key factors driving the Global Stem Cell Cartilage Regeneration Market?

What are the key market trends impacting the growth of the Global Stem Cell Cartilage Regeneration Market?

What are the challenges to market growth?

Who are the key vendors in the Global Stem Cell Cartilage Regeneration Market?

What are the market opportunities and threats faced by the vendors in the Global Stem Cell Cartilage Regeneration Market?

Trending factors influencing the market shares of the Americas, APAC, Europe, and MEA.

This unique market intelligence report from the author provides information not available from any other published source. The report includes diagnostics sales and market share estimates by product as well as a profile of the companys diagnostics business.

The report, focuses on the global Stem Cell Cartilage Regeneration market, and answers some of the most critical questions stakeholders are currently facing across the globe. Information about the size of the market (by the end of the forecast year), companies that are most likely to scale up their competitive abilities, leading segments, and challenges impeding the growth of the market are given.

Analysis tools such as SWOT analysis and Porters five force model have been inculcated in order to present a perfect in-depth knowledge about Stem Cell Cartilage Regeneration market. Ample graphs, tables, charts are added to help have an accurate understanding of this market. The Stem Cell Cartilage Regeneration market is also been analyzed in terms of value chain analysis and regulatory analysis.

The report includes six parts, dealing with:

1.) Basic information;

2.) The Asia Stem Cell Cartilage Regeneration Market;

3.) The North American Stem Cell Cartilage Regeneration Market;

4.) The European Stem Cell Cartilage Regeneration Market;

5.) Market entry and investment feasibility;

6.) The report conclusion.

Reasons for Buying this Report

This report provides pin-point analysis for changing competitive dynamics

It provides a forward looking perspective on different factors driving or restraining market growth

It provides a six-year forecast assessed on the basis of how the market is predicted to grow

It helps in understanding the key product segments and their future

It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors

It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments

TABLE OF CONTENT:

1 Report Overview

2 Global Growth Trends

3 Market Share by Key Players

4 Breakdown Data by Type and Application

5 United States

6 Europe

7 China

8 Japan

9 Southeast Asia

10 India

11 Central & South America

12 International Players Profiles

13 Market Forecast 2020-2027

14 Analysts Viewpoints/Conclusions

15 Appendix

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Research On Global Stem Cell Cartilage Regeneration Market (impact of COVID-19), Analysis, Overview, Growth Forecast, Top key players Anika...

Readers ask about antibody tests, chimeras and public health and privacy – Finance Brokerage

Antibody mysteries

Antibody tests can help reveal who has been infected with the coronavirus, but the tests dont say whether the antibodies protect against future infections, Erin Garcia de Jesus reported in So many questions on antibody testing (SN: 6/6/20, p. 22).

Reader Bob Reckers asked if antibodies for cold-causing coronaviruses, which are detectable by the coronavirus antibody tests, could bind to the coronavirus. This could explain the wide variations in severity of COVID19 infections, he wrote. People who recently had a (cold) might have some level of protection.

Antibodies produced in reaction to some colds certainly could bind to the coronavirus that causes COVID-19, says Garcia de Jesus. But those antibodies dont appear to last long. Its unclear whether antibodies from a recent cold would offer protection or worsen COVID-19 symptoms, she says. For dengue viruses, antibodies sometimes can lead to severe symptoms. When people who have had dengue are infected with a different strain, antibodies from the previous infection help the new virus invade cells, putting those people at higher risk for severe symptoms. Theres no evidence in people either way for COVID-19, and not enough time has passed for researchers to fully study this question, Garcia de Jesus says.

Cell phone apps that have helped South Korea and China get a grip on the coronavirus spread could help public health workers in the United States, Jonathan Lambert reported in A sprint to contact tracing (SN: 6/6/20, p. 19).

To comply with contact tracing apps, people in the United States must know that their privacy is protected, reader Cielo DeCastro noted. It must be made explicit that identification between devices is anonymized and securely stored in encrypted form to prevent violation of privacy. The application should not gather any other information or track ones geolocation, he wrote. DeCastro acknowledged that phone tracking may be necessary for public health, but the peoples right to privacy must not be overlooked.

Lambert agrees that privacy around contact tracing apps is a major issue. The TraceTogether app mentioned in the story uses anonymized data gained through proximity tracking, whereby a phone exchanges encrypted data via Bluetooth with nearby phones. This method is considered less invasive than the geolocation tracking used by many apps on our phones (SN: 2/3/18, p. 18).

In June, U.S. legislators introduced the Exposure Notification Privacy Act. This bill would require anyone who operates a contact tracing app to collaborate with public health officials, make app use voluntary and prevent commercial use of data collected by the apps.

Scientists coaxed human stem cells into populating various organs and blood of growing mouse embryos, Laura Sanders reported in Mouse embryos host human cells (SN: 6/6/20, p. 7).

The story made my skin crawl, reader Jerome Knies wrote. What kind of moral supervision governs such experimentation?heasked.

Little clarity exists, Sanders says. Individual countries have an array of guidelines for conducting human chimera experiments, and individual research institutions often have their own approval committees, she says. For what its worth, the International Society for Stem Cell Research highlights two potential concerns: chimeras with humanlike brains and chimeras that can pass human genes to offspring. The organization flagged those scenarios as ones that require careful ethical considerations, Sanders says.

Quantum computings error problem (SN: 6/20/20, p. 18) explained how two photons within a superconducting microwave cavity might represent a value of 0, with four qubits representing 1. This is incorrect. Four photons would represent 1.

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Readers ask about antibody tests, chimeras and public health and privacy - Finance Brokerage

Gene variants and susceptibility to schizophrenia – The Hindu

Schizophrenia is a constellation of symptoms such as hearing voices, false beliefs and trouble with thinking and concentration, and its cause is not exactly known. In that sense, schizophrenia is still an enigma.

Studies of schizophrenia among groups of varied ethnicities across the world have shown associations of the disease with alleles (variant genes) related to the human leukocyte antigen an important part of the immune system and related to a group of genes on chromosome six. However, the specific allele that was found to be associated with schizophrenia varied from group to group.

Recently, a pilot study on a south Indian, Tamil-speaking group consisting of 97 people with schizophrenia and 103 controls was carried out by Schizophrenia Research Foundation (SCARF) and Jeevan Stem Cell Foundation, in Chennai. The study, published in International Journal of Immunogenetics finds an association of specific alleles with the disease.

The paper shows an association between HLA variations and schizophrenia. HLA is important for proper functioning of immune system and its variations can lead to immunological abnormalities. When the immune system acts up, as in autoimmune disorders, generating anti-NMDA receptor antibodies, for example, it can lead to schizophrenia, says Dr Vijaya Raghavan, Consultant Psychiatrist, Research, SCARF.

Earlier studies indicate that different variants of specific genes (these variants are called alleles) may be involved in different ethnic groups.

Studies done in Saudi Arabia and Tunisia have shown a particular HLA allele (DRB1*03) to be a risk factor for schizophrenia but in [a study involving a] Japanese population it was a different allele (DRB1*01) which predisposed to the disease condition, says Dr S. Vani Laboratory Director, Jeenomics, Jeevan Stem cell Foundation, Chennai, in an email to The Hindu.She is a principal investigator of the present study along with Dr. Vijaya Raghavan.

The occurence of different variants itself is not a problem, as HLA genes are extremely variable and are very different across human populations, according to Prof. Sanjeev Jain, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, who was not involved in the study. The reasons are not entirely clear, but perhaps selection and memory of past selection pressures (infections) play a role, he adds.

In the present study, the researchers found that there was a higher frequency of HLA class I alleles ( HLA-A*01:01:01, -B*37:01:01 and -C*01:02:01) in individuals with schizophrenia as compared to the controls. Individuals carrying these alleles could be susceptible to schizophrenia.

They also found a negative correlation with some alleles (HLA-B*35:03:01 and HLA-DRB1*04:03:01) which were found in lower frequency in individuals with schizophrenia. These could be protective alleles in schizophrenia.

The paper adds a valuable piece of information, on the relation between immune response genes and schizophrenia, says Prof. Jain. It is a small sample, and the associations are observed only in a subset (often females only); correcting for multiple comparisons may reduce the significance of the findings he adds.

The researchers also studied the type of amino acid present in the peptide binding groove of HLA molecule and compared it among patients and controls, finding a significant difference. The amino acid level association study has not been reported earlier in schizophrenia, says Dr. Vani, adding that the results need to be strengthened further using a larger sample size.

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Gene variants and susceptibility to schizophrenia - The Hindu

How COVID-19 Pandemic Will Impact Australia & New Zealand Research Antibodies Market Business Opportunity, And Growth 2020-2026 Bulletin Line -…

Trusted Business Insights answers what are the scenarios for growth and recovery and whether there will be any lasting structural impact from the unfolding crisis for the Australia & New Zealand Research Antibodies market.

Trusted Business Insights presents an updated and Latest Study on Australia & New Zealand Research Antibodies Market 2019-2026. The report contains market predictions related to market size, revenue, production, CAGR, Consumption, gross margin, price, and other substantial factors. While emphasizing the key driving and restraining forces for this market, the report also offers a complete study of the future trends and developments of the market.The report further elaborates on the micro and macroeconomic aspects including the socio-political landscape that is anticipated to shape the demand of the Australia & New Zealand Research Antibodies market during the forecast period (2019-2029). It also examines the role of the leading market players involved in the industry including their corporate overview, financial summary, and SWOT analysis.

Get Sample Copy of this Report @ Australia & New Zealand Research Antibodies Market Size Report, 2026 (Includes Business Impact of COVID-19)

Industry Insights, Market Size, CAGR, High-Level Analysis: Australia & New Zealand Research Antibodies Market

The Australia & New Zealand research antibodies market size was valued at USD 98.4 million in 2018 and is anticipated to grow at a CAGR of 8.4% during the forecast period. Rise in the number of initiatives being undertaken by the Australian government to advance the biotechnology sector is expected to fuel the growth in the country. In May 2019, Federal Labor offered businesses an R&D tax offset for collaborating with science-based agencies and universities, such as The Commonwealth Scientific and Industrial Research Organisation (CSIRO), to promote innovation and knowledge in biotechnology sector. In addition, a 10% tax can be added to the calculated tax offset if a business is collaborating with any public institution. This plan would help in increasing R&D investments in Australia to 3% of GDP by 2030 and is expected to act as a key tool for fostering an alliance between research and industry, thereby improving industrial capabilities in Australia. R&D tax incentive in Australia has encouraged biotechnology companies in the region to conduct R&D. For instance, in 2018, Shape Pharmaceuticals, Inc. supported R&D investments in Australian biotechnology industry by conducting clinical trials to study the effect of SHP-141 on patients diagnosed with psoriasis. These tax incentives help companies achieve cost advantage while selecting clinical trial sites for R&D processes.

Rise in R&D investments by the government is also expected to boost the market. In 2018, the Victorian government allocated USD 1.5 million for establishment of an Advanced Biotechnology Manufacturing Platform to enhance production of antibodies, vaccines, stem cells, and growth factors, among others, for testing in human clinical trials. This facility would enable various Australian biotechnology companies to conduct R&D in the state, thereby generating jobs and propelling growth of various companies currently conducting clinical trials in Victoria. The government is also promoting development of the biotechnology sector through Future Industries Fund. Growth in stem cell and neurobiology-based research is expected to boost the market over the forecast period. The Center of Research Excellence in Neuromuscular Disorders Australia is a wide collaboration of neuromuscular experts, who use advanced technologies and approaches in science & medicine to improve diagnosis. In addition, it aims to transform treatment to effective therapy of neurological diseases from compassionate management. The Australian Neuromuscular Network was formed in the year 2010 by the Center of Research Excellence in Neuromuscular Disorders along with other neuromuscular specialists, scientists, and professionals across New Zealand and Australia. Rise in the prevalence of neurological disorders is expected to boost the market. According to the Neurological Foundation of New Zealand, by 2051, about one-third of the population in New Zealand will be 65 years and above. The prevalence of dementia is therefore expected to increase, leading to a rise in R&D pertaining to treatment for various neurological disorders. However, stringent government regulations that can limit research activities are expected to restrain market growth.

Product Insights of Australia & New Zealand Research Antibodies Market

On basis of product, Australia & New Zealand research antibodies market is segmented into primary and secondary antibodies. Primary antibodies held the largest share and is anticipated to witness the highest CAGR owing to rise in adoption of reagents developed using antibodies, due to the various benefits associated with them such as greater specificity, easy availability, and suitability in various research applications. Similarly, primary antibodies are anticipated to grow at a faster rate during the forecast period due to varied applications in research. In addition, rise in prevalence of chronic diseases, such as diabetes, cancer, and Alzheimers disease, is leading to an increase in adoption of primary antibodies. Increasing R&D in the country is further anticipated to boost the adoption of secondary antibodies as well. Thus, rising adoption of these antibodies in research for development of alternative therapies is anticipated to create significant demand for these products over the forecast period. End-use Insights Pharmaceutical & biotechnology companies held the largest share of the end-use segment in 2018, which can be attributed to increase in adoption of antibodies in drug development and research organizations. Contract research organizations are anticipated to grow at a lucrative CAGR during the forecast period owing to cost-effectiveness.

The academic & research institutes segment is expected to witness constant growth owing to the presence of various academic research groups that are involved in the study of complex biological systems using advanced reagents. Benefits such as greater understanding of biological processes and complex systems are anticipated to create growth opportunities in the segment. Contract research organizations are anticipated to grow at a lucrative CAGR during the forecast period. Majority of the companies prefer CROs owing to the various advantages associated with contract services. These benefits include cost advantage, increased efficiency of services, and enhanced productivity, which help a company focus on its core expertise.

Type Insights of Australia & New Zealand Research Antibodies Market

On the basis of antibody type, the market is segmented into monoclonal and polyclonal antibodies. Monoclonal antibodies held the largest market share due to increase in research on genomics and personalized medicine, which has led to increase in the use of these antibodies. As monoclonal antibodies are relatively cost-effective, they are anticipated to grow at a higher rate than polyclonal antibodies. Polyclonal antibodies have several advantages over monoclonal in various diagnostic settings. Polyclonal antibodies are often the most preferred option in routine laboratory tests such as Enzyme-Linked Immunosorbent Assay (ELISA), microarray assays, western blotting, flow cytometry, and immunohistochemistry. Their production does not require skilled professionals, and large batches can be produced as per client requirements. These antibodies can recognize multiple antigens on one epitope and can therefore be utilized in the study of various diseases ranging from cancer to metabolic Polyclonal antibodies are relatively inexpensive in comparison with monoclonal antibodies, which may fuel their demand in low-budget and non-funded research projects. However, polyclonal antibodies can differ from batch to batch depending upon manufacturing and quality control process. These antibodies can recognize multiple epitopes, thus increasing the probability of nonspecific antigen binding.

Technology Insights of Australia & New Zealand Research Antibodies Market

On the basis of technology, the Australia & New Zealand research antibodies market is segmented into western blotting, immunoprecipitation, immunochemistry, ELISA, immunofluorescence, flow cytometry, and other technologies. Western blotting held the largest share of the technology segment in 2018 owing to rising demand for rapid diagnostic methods. On the other hand, technical upgradation is anticipated to create growth prospects for technologies in pipeline. ELISA is anticipated to witness the highest CAGR during the forecast period owing to conventional use of polyclonal antibodies in sandwich ELISA. ELISA is an analytical test that essentially uses antibodies to identify substances in samples. These tests are most often used to accurately diagnose diseases, such as AIDS, Lyme disease, syphilis, pernicious anemia, Rocky Mountain spotted fever, squamous cell carcinoma, chickenpox, shingles, and other bacterial & viral infections. Western blotting held the largest share in 2018 owing to rise in prevalence of diseases with limited number of treatment options. Western blotting offers high accuracy and sensitivity and is considered a gold standard for testing. In addition, increase in government initiatives to fund research activities is one of the factors contributing to the highest market share held by this segment, as it is conventionally used in research laboratories. Source Insights The mouse segment held the largest share in 2018 as mice are convenient to use during production of antibodies for research purposes and have wide range of applications. Others segment is expected to grow exponentially, as it has a wide range of applications. The use of murine monoclonal antibodies is increasing in various end-use settings, which is expected to positively impact market growth. Mice have been predominantly used in production of antibodies. The structural similarities in mice and human antibodies is a prime factor responsible for high adoption. Cost-effectiveness and the ability to multiply quickly are among the factors fueling growth of this segment. Moreover, mouse-derived monoclonal and polyclonal antibodies are relatively easier to produce and possess greater specificity. Technological advancements in the development processes of these products, such as hybridoma technology that aids in production of monoclonal antibodies in specialized cells, are further augmenting demand for mouse antibodies. Rabbits are also extensively used for production of antibodies, owing to various advantages such as higher affinity and specificity in comparison with antisera obtained from other animal hosts. Higher specificity of these products makes them ideal for use in detection of small molecules, such as pollutants; toxins; hormones; drugs; nonprotein targets, such as carbohydrates & lipids; and post-translational alterations such as phosphorylation.

Application Insights of Australia & New Zealand Research Antibodies Market

Oncology held the largest share of the application segment in 2018. The largest share can be attributed to growing prevalence of cancer, which leads to an increase in the need for R&D pertaining to advanced therapeutics. On the other hand, stem cell is anticipated to witness lucrative CAGR during the forecast period owing to significant increase in stem cells research. Rising prevalence of infectious diseases, growing geriatric population, decreasing immunity levels, and rising awareness among people about communicable diseases are some of the high impact-rendering drivers of the market. Growing incidence of autoimmune diseases coupled with limited presence of advanced therapeutics is predominantly driving segment growth. Significant advancements in immunology research have boosted adoption of research antibodies in the recent years. Oncology accounted for the largest share of research antibodies in 2018.The segment is also anticipated to grow at a considerable CAGR owing to increasing incidence of cancer. According to WHO, the number of new cancer cases is anticipated to increase by approximately 70.0% in the next two decades. Monoclonal antibodies are also used for diagnosis of lymphoid & myeloid malignancies, tissue typing, and immunological intervention using passive antibody. Owing to the steady increase in the demand for transplantable tissues and low-quality donor cells, stem cell research segment is expected to grow. Moreover, increasing adoption of cell isolation and culture, which involves use of research antibodies, is further anticipated to broaden segment growth prospects.

Market Share Insights of Australia & New Zealand Research Antibodies Market

Some major players in this market are PerkinElmer, Inc.; F.Hoffmann La Roche Ltd.; Thermo Fisher Scientific; Merck Millipore; Bio-Rad Laboratories; Abcam PLC; BD; Lonza Group; Cell Signaling Technology, Inc.; and Agilent Technologies. Increase in the number of products launched by market players is expected to fuel market growth. For instance, in April 2019, Bio-Rad launched a range of isotype-specific secondary antibodies-IgG1, IgG2a, and IgG2b. These products are used to offer specificity when used in ELISA, imaging, western blotting, and flow cytometry, among others, as well as for improved signaling. Mergers & acquisitions and collaborations are some of the other strategic initiatives undertaken by leading players to gain market share, for instance, Abcam Plc acquired Calico Biolabs. This initiative helped the company expand its product portfolio through the addition of high-quality recombinant rabbit monoclonal antibodies for immunohistochemistry. As per the agreement, Abcam was to also expand its custom rabbit monoclonal antibody production. These factors are further anticipated to aid growth during the forecast period.

Segmentations, Sub Segmentations, CAGR, & High-Level Analysis overview of Australia & New Zealand Research Antibodies Market Research Report This report forecasts revenue growth at country level and provides an analysis on the latest industry trends in each of the sub-segments from 2015 to 2026. For the purpose of this study, this market research report has segmented the Australia & New Zealand research antibodies market report on the basis of product, type, technology, source application, end use, and country:

Product Outlook (Revenue, USD Million, 2019 2030)

Primary

Secondary

Type Outlook (Revenue, USD Million, 2019 2030)

Monoclonal Antibodies

Polyclonal Antibodies

Technology Outlook (Revenue, USD Million, 2019 2030)

Immunohistochemistry

Immunofluorescence

Western Blotting

Flow Cytometry

Immunoprecipitation

ELISA

Others

Source Outlook (Revenue, USD Million, 2019 2030)

Mouse

Rabbit

Goat

Others

Application Outlook (Revenue, USD Million, 2019 2030)

Infectious Diseases

Immunology

Oncology

Stem Cells

Neurobiology

Others

End-use Outlook (Revenue, USD Million, 2019 2030)

Academic & Research Institutes

Contract Research Organizations

Pharmaceutical & Biotechnology Companies

Quick Read Table of Contents of this Report @ Australia & New Zealand Research Antibodies Market Size Report, 2026 (Includes Business Impact of COVID-19)

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