Animal Stem Cell Therapy Market forecasted to surpass the value of ~US$ XX Mn/Bn by 2017 – 2025 – The Market Expedition

Assessment of the Animal Stem Cell Therapy Market

Persistence Market Research recently published a report which provides a deep understanding of the various factors that are likely to influence the prospects of the Animal Stem Cell Therapy market in the forecast period 2017 2025. The study takes into account the historical and current market trends to predict the course of the Animal Stem Cell Therapy Market in the upcoming years. Further, the growth opportunities, drivers, and major challenges faced by market players in the Animal Stem Cell Therapy Market are discussed in detail.

The team of analysts at PMR, track the major developments within the Animal Stem Cell Therapy sphere in various geographies. The market share, size, and value of each region are discussed in the report along with explanatory graphs, tables, and figures.

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As per the findings of the report, the Animal Stem Cell Therapy Market is slated to grow at a CAGR of ~XX% during the forecast period and attain a market value of ~US$XX by the end of 2029. The report introspects the various factors that are anticipated to have a significant impact on the growth of the Animal Stem Cell Therapy market over the assessment period 2017 2025.

This chapter of the report discusses the ongoing developments of leading companies operating in the Animal Stem Cell Therapy Market. The product portfolio, pricing strategy, the regional and global presence of each company is thoroughly discussed in the report.

Critical Market Information Enclosed in the Report:

Doubts Related to the Animal Stem Cell Therapy Market Catered to in the Report:

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Key Participants

The key participants in the animal stem cell therapy market are Magellan Stem Cells, ANIMAL CELL THERAPIES, Abbott Animal Hospital, VETSTEM BIOPHARMA, Veterinary Hospital and Clinic Frisco, CO, etc. The companies are entering into the collaboration and partnership to keep up the pace of the innovations.

The report covers exhaustive analysis on:

Regional analysis for Market includes

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Animal Stem Cell Therapy Market forecasted to surpass the value of ~US$ XX Mn/Bn by 2017 - 2025 - The Market Expedition

Stem Cell Assay Market Estimated to Record Highest CAGR by 2017 – 2025 – The Market Expedition

Assessment of the Stem Cell Assay Market

Persistence Market Research recently published a report which provides a deep understanding of the various factors that are likely to influence the prospects of the Stem Cell Assay market in the forecast period 2017 2025. The study takes into account the historical and current market trends to predict the course of the Stem Cell Assay Market in the upcoming years. Further, the growth opportunities, drivers, and major challenges faced by market players in the Stem Cell Assay Market are discussed in detail.

The team of analysts at PMR, track the major developments within the Stem Cell Assay sphere in various geographies. The market share, size, and value of each region are discussed in the report along with explanatory graphs, tables, and figures.

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As per the findings of the report, the Stem Cell Assay Market is slated to grow at a CAGR of ~XX% during the forecast period and attain a market value of ~US$XX by the end of 2029. The report introspects the various factors that are anticipated to have a significant impact on the growth of the Stem Cell Assay market over the assessment period 2017 2025.

This chapter of the report discusses the ongoing developments of leading companies operating in the Stem Cell Assay Market. The product portfolio, pricing strategy, the regional and global presence of each company is thoroughly discussed in the report.

Critical Market Information Enclosed in the Report:

Doubts Related to the Stem Cell Assay Market Catered to in the Report:

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The major players in the global stem cell assay market include GE Healthcare, Promega Corporation, Thermo Fisher Scientific Inc., Merck KGaA, Cell Biolabs, Inc., Hemogenix Inc., Stemcell Technologies Inc., Bio-Rad Laboratories Inc., R&D Systems Inc., and Cellular Dynamics International Inc.

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Stem Cell Assay Market Estimated to Record Highest CAGR by 2017 - 2025 - The Market Expedition

Autologous Stem Cell and Non Stem Based therapies Market Size SWOT Analysis of Top Key Player Forecasts To 2025 – Markets Gazette 24

Autologous Stem Cell and Non Stem Based therapies Market research now available at Brand Essence Research encompasses an exhaustive Study of this business space with regards to pivotal industry drivers, market share analysis, and the latest trends characterizing the Autologous Stem Cell and Non Stem Based therapies industry landscape. This report also covers details of market size, growth spectrum, and the competitive scenario of Autologous Stem Cell and Non Stem Based therapies market in the forecast timeline.

The Autologous Stem Cell and Non Stem Based therapies Market Report provides key strategies followed by leading Autologous Stem Cell and Non Stem Based therapies industry manufactures and Sections of Market like- product specifications, volume, production value, Feasibility Analysis, Classification based on types and end user application areas with geographic growth and upcoming advancement. The Autologous Stem Cell and Non Stem Based therapies market report provides comprehensive outline of Invention, Industry Requirement, technology and production analysis considering major factors such as Revenue, investments and business growth.

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The well-established players in the market are:

Compnies 1, Compnies 2, Compnies 3

This report for Autologous Stem Cell and Non Stem Based therapies Market discovers diverse topics such as regional market scope, product market various applications, market size according to specific product, sales and revenue by region, manufacturing cost analysis, Industrial Chain, Market Effect Factors Analysis, market size forecast, and more.

Drivers & Hindrances of the Autologous Stem Cell and Non Stem Based therapies market: How does the report explicate on the same

The report unveils the driving parameters affecting the commercialization chart of this industry.

The Autologous Stem Cell and Non Stem Based therapies market research report further illustrates the various challenges that this market is prone to as well as its impact on the market trends.

An important aspect that the report sets focus on is the market concentration ratio for the predicted timeframe.

The geographical spectrum of the business and its consequence on the Autologous Stem Cell and Non Stem Based therapies market:

The report segments the Autologous Stem Cell and Non Stem Based therapies market into USA, Europe, Japan, China, India, South East Asia depending on the regional scope of this business

Extensive data about the product consumption across innumerable sections as well as the valuation developed by these regions is also explained in the report.

The study puts emphasis on data concerning the consumption market share across these regions, as well as the market share attained by every region and product consumption growth rate.

Market segment by Type, the product can be split into

XXXX

Market segment by Application, split into

YYYY

Market segment by Regions/Countries, this report covers

North America (United States, Canada and Mexico)

Europe (Germany, UK, France, Italy, Russia and Turkey etc.)

Asia-Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Malaysia and Vietnam)

South America (Brazil etc.)

Middle East and Africa (Egypt and GCC Countries)

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Key highlights and essential features of the report:

1) Which major players are presently listed in the report?Here are the companies that are presently listed in the report:Compnies 1, Compnies 2, Compnies 3

**List of the firms stated above might differ in the final report dependent on a merger, name change, and other factors.

2) Can you list or add new firms as per our requirement?Yes,we can list or add new firm as per the requirement by client in the report. The final confirmation regarding the same must be provided by the research team subject to difficulty of survey.

**Availability of data will be confirmed after research in case of a privately held firm. Maximum 3 companies can be included at no additional charge.

3) Which all regional categorization are covered? Is it possible to add any specific country?Presently, our research report offers special focus and attention on the following areas:Europe, United States, Japan, China, India, Southeast Asia, and Central & South America

**Maximum one country of specific interest can be added at no extra charge. Charges will be applied for the addition of extra countries or regions.

4) Can the addition of extra Market breakdown or segmentation is possible?Yes, the addition of extra Market breakdown or segmentation is possibly dependent on the difficulty of survey and availability of data. On the other hand, detailed sharing of the requirements with our research team is a must before providing final confirmation to the client.

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Table of Content:

Market Overview:The report begins with this section where product overview and highlights of product and application segments of the global Autologous Stem Cell and Non Stem Based therapies Market are provided. Highlights of the segmentation study include price, revenue, sales, sales growth rate, and market share by product.

Competition by Company:Here, the competition in the Worldwide Autologous Stem Cell and Non Stem Based therapies Market is analyzed, By price, revenue, sales, and market share by company, market rate, competitive situations Landscape, and latest trends, merger, expansion, acquisition, and market shares of top companies.

Company Profiles and Sales Data:As the name suggests, this section gives the sales data of key players of the global Autologous Stem Cell and Non Stem Based therapies Market as well as some useful information on their business. It talks about the gross margin, price, revenue, products, and their specifications, type, applications, competitors, manufacturing base, and the main business of key players operating in the global Autologous Stem Cell and Non Stem Based therapies Market.

Market Status and Outlook by Region:In this section, the report discusses about gross margin, sales, revenue, production, market share, CAGR, and market size by region. Here, the global Autologous Stem Cell and Non Stem Based therapies Market is deeply analyzed on the basis of regions and countries such as North America, Europe, China, India, Japan, and the MEA.

Application or End User:This section of the research study shows how different end-user/application segments contribute to the global Autologous Stem Cell and Non Stem Based therapies Market.

Market Forecast:Here, the report offers a complete forecast of the global Autologous Stem Cell and Non Stem Based therapies Market by product, application, and region. It also offers global sales and revenue forecast for all years of the forecast period.

Research Findings and Conclusion:This is one of the last sections of the report where the findings of the analysts and the conclusion of the research study are provided.

Appendix:Here, we have provided a disclaimer, our data sources, data triangulation, research programs, market breakdown and design, and our research approach.

https://www.marketwatch.com/press-release/trends-of-thermoplastic-polyolefin-market-size-reviewed-for-2019-with-outlook-to-2025-2019-12-03

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Autologous Stem Cell and Non Stem Based therapies Market Size SWOT Analysis of Top Key Player Forecasts To 2025 - Markets Gazette 24

Global Stem Cell Banking Storage Market 2019 by Company, Regions, Type and Application, Forecast to 2025 – Industry News Info

The Stem Cell Banking Storage Market report gives a purposeful depiction of the area by the practice for research, amalgamation, and review of data taken from various sources. The market analysts have displayed the different sidelines of the area with a point on recognizing the top players (CCBC, CBR, ViaCord, Esperite, Vcanbio, Boyalife, LifeCell, Crioestaminal, RMS Regrow, Cordlife Group, PBKM FamiCord, cells4life, Beikebiotech, StemCyte, Cryo-cell, Cellsafe Biotech Group, PacifiCord, Americord, Krio, Familycord, Cryo Stemcell) of the industry. The Stem Cell Banking Storage market report correspondingly joins a predefined business market from a SWOT investigation of the real players. Thus, the data summarized out is, no matter how you look at it is, reliable and the result of expansive research.

This report mulls over Stem Cell Banking Storage showcase on the classification, for instance, application, concords, innovations, income, improvement rate, import, and others (Diseases Therapy, Healthcare) in the estimated time from 20192025 on a global stage. In like manner, the overall Stem Cell Banking Storage market report reveals knowledge identified with the type of product, its applications, customers, prime players, and various components agreeing with the account. This first data demonstrates critical contenders and their definite picture of the general Stem Cell Banking Storage market. Other than this, the report further demonstrates expected market power, challenges, and prospects in the Stem Cell Banking Storage market.

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Types Segment:Umbilical Cord Blood Stem Cell, Embryonic Stem Cell, Adult Stem Cell, Other

Key Market Features:

The scope of the report extends from market eventualities to a comparative rating between major players, price, and profit of the required market regions. This makes available the holistic view on competitive analysis of the market. Some of the top players involved in the market are profiled completely in a systematic manner. In the end, the report concludes the new project, key development areas, business overview, product/services specification, SWOT analysis, investment feasibility analysis, return analysis and development trends. The study also presents a round-up of vulnerabilities in which companies operating in the market and must be avoided in order to enjoy sustainable growth through the course of the forecast period.

The study provides a comprehensive analysis of the key market factors and their latest trends, along with relevant market segments and sub-segments. Market size is calculable in terms of revenue (USD Million) production volume during the forecast period.

Global Stem Cell Banking Storage Market report provides a valuable source of insightful data for business strategists. It provides the industry overview with growth analysis and historical & futuristic cost, revenue, demand and supply data (as applicable). The research analysts provide an elaborate description of the value chain and its distributor analysis. The report also looks at the influential factors that are affecting the development of the Global Automotive Bumpers Market. This statistical report also offers various internal and external driving as well as restraining factors for this research report.

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Essential application areas of Stem Cell Banking Storage are also measured on the basis of their performance. Market forecasts along with the statistical nuances presented in the report render an insightful view of the Stem Cell Banking Storage market. The market study on report studies present as well as coming aspects of the Stem Cell Banking Storage Market mainly based upon factors on which the companies contribute to the market evolution, key trends, and segmentation analysis.

The scope of the report extends from market eventualities to a comparative rating between major players, price, and profit of the required market regions. This makes available the holistic view on competitive analysis of the market. Some of the top players involved in the market are profiled completely in a systematic manner.

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Global Stem Cell Banking Storage Market 2019 by Company, Regions, Type and Application, Forecast to 2025 - Industry News Info

Stem Cell Banking Market to Witness an Outstanding Growth by 2018 – 2026 – Weekly Spy

Assessment of the Stem Cell Banking Market

Persistence Market Research recently published a report which provides a deep understanding of the various factors that are likely to influence the prospects of the Stem Cell Banking market in the forecast period 2018 2026. The study takes into account the historical and current market trends to predict the course of the Stem Cell Banking Market in the upcoming years. Further, the growth opportunities, drivers, and major challenges faced by market players in the Stem Cell Banking Market are discussed in detail.

The team of analysts at PMR, track the major developments within the Stem Cell Banking sphere in various geographies. The market share, size, and value of each region are discussed in the report along with explanatory graphs, tables, and figures.

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As per the findings of the report, the Stem Cell Banking Market is slated to grow at a CAGR of ~XX% during the forecast period and attain a market value of ~US$XX by the end of 2029. The report introspects the various factors that are anticipated to have a significant impact on the growth of the Stem Cell Banking market over the assessment period 2018 2026.

This chapter of the report discusses the ongoing developments of leading companies operating in the Stem Cell Banking Market. The product portfolio, pricing strategy, the regional and global presence of each company is thoroughly discussed in the report.

Critical Market Information Enclosed in the Report:

Doubts Related to the Stem Cell Banking Market Catered to in the Report:

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key players of the global stem cell banking market are NeoStem, Esperite, Smart Cells International, StemCyte, ViaCord, Capricor, CordCare, Cryo Stemcell, Cellartis and Aldagen. The key players from the North America and Europe are contributing major share to the global stem cells banking market.

Overall, the global stem cell banking market has expected to register the significant growth over the forecast period.

The report covers exhaustive analysis on:

Regional analysis includes

Report Highlights:

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Stem Cell Banking Market to Witness an Outstanding Growth by 2018 - 2026 - Weekly Spy

Stem Cell Banking Market Advanced technologies & growth opportunities in global Industry by 2018 – 2026 – Markets Gazette 24

Stem Cell Banking market research study in brief

The business intelligence study for the Stem Cell Banking market provides an extensive synopsis of essential aspects involving the product classification, important definitions, and other industry-specific parameters. The report also covers the key factors associated with the current events such as alliances, mergers & acquisitions, and new product launches.

Additionally, the Stem Cell Banking market study puts forth a rigid basis for collecting a cluster of insights that potential customers can use to enhance their revenues and reduce costs. The illustration of data on Stem Cell Banking market segmentation by type, application, and geography offers a critical viewpoint of, what manufacturers are eyeing for the stipulated timeframe, 2019 2026.

This article will help the Stem Cell Banking vendors understand the volume expansion outlook with impacting trends.

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All of the segments covered in the research study are examined on the basis of BPS, market share, revenue, and other crucial factors. Our business study presents how various segments are adding to the growth of the global Stem Cell Banking market. It also offers information on key trends with regards to the segments studied in the report. This supports market players to focus on promising regions of the global Stem Cell Banking market. The research study also delivers independent analysis on the segments as per absolute dollar opportunity.

Market segments and sub-segments

The regional analysis covers:

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industrys value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

Highlights of the report:

Note:Although care has been taken to maintain the highest levels of accuracy in TMRs reports, recent market/vendor-specific changes may take time to reflect in the analysis.

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Stem Cell Banking Market Advanced technologies & growth opportunities in global Industry by 2018 - 2026 - Markets Gazette 24

Global Stem Cell Banking Market with Geographic Segmentation, Demand by Regions, Statistical Forecast and Competitive Landscape Research upto…

The Latest forecast study by the Global Markerters.biz has publicized a new report on Global Stem Cell Banking Market, forecasting the analysis from 2019-2026. The report embraces various factors including the overall growth dynamics, market estimation, development prospects across different geographies, and competitive analysis. The preliminary part of the report give a syntactic representation of the market summary, specification, product definition, and objectives.

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Key Players of Stem Cell Banking Report are:

CrioestaminalRMS RegrowLifeCellBoyalifeVcanbioKrioEsperiteBeikebiotechCryo-cellPacifiCordCryo StemcellCells4lifePBKM FamiCordStemade BiotechCellsafe Biotech GroupAmericordViaCordCordlife GroupCCBCFamilycordCBRStemCyte

The surveys and interviews get conducted to obtain the newest financial information on Stem Cell Banking are calculated and estimated through various paid secondary sources and hence they are further validated by primary respondents.

We follow a strict research tactics so that our customers should get reliable and accurate information which would help them to make sound business decisions.

Market segments and sub-segments

The geographical analysis covers the following regions:

North America (Canada & U.S.) & Latin America (Mexico, Brazil, Peru, Chile, and others)

Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg) & Eastern Europe (Poland and Russia)

Asia-Pacific (China, India, Japan, ASEAN, Australia, and New Zealand)

Middle-East & Africa (GCC, Southern Africa, and North Africa)

Important aspects of the report

The report is comprised of leading market players information for analyzing the market such as company mug shot, contact details, product collection, production and consumption statistics, sales, revenue, market positions, etc.

A SWOT analysis covers various fundamental facets of the market involving its strengths, weaknesses as well as its external opportunities and threats.

Historic, Current, and forecast of Stem Cell Banking market assessment across various regions for major and evolving market contestants.

Inspects the growth plans, industry policies, market size, value and sales of top Stem Cell Banking players.

Studies crucial factors like market risks, drivers, and maturity analysis.Provides a detailed understanding about the new product inauguration events, mergers, and acquisitions, and competitive growth.

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The market is segmented into below points:

Global Stem Cell Banking Market by Type/Products:

Placental Stem Cells (PSCs)Human Embryo-derived Stem Cells (HESCs)Bone Marrow-derived Stem Cells (BMSCs)Adipose Tissue-derived Stem Cells (ADSCs)Dental Pulp-derived Stem Cells (DPSCs)Other Stem Cell Sources

Global Stem Cell Banking Market by Application/End-Use:

Personalized Banking ApplicationsClinical ApplicationsHematopoietic DisordersAutoimmune DisordersOther DiseasesResearch ApplicationsDisease Treatment StudiesLife Science ResearchDrug Discovery

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How Flight Feathers Evolved: Study of Chickens, Ostriches, Penguins, Ducks and Eagles – SciTechDaily

This picture shows a spirited flying Taiwan Blue Magpie displaying a full array of flight feathers in action. Credit: Shao Huan Lang

If you took a careful look at the feathers on a chicken, youd find many different forms within the same birdeven within a single feather. The diversity of feather shapes and functions expands vastly when you consider the feathers of birds ranging from ostriches to penguins to hummingbirds. Now, researchers reporting in the journal Cell on November 27, 2019, have taken a multidisciplinary approach to understanding how all those feathers get made.

We always wonder how birds can fly and in different ways, says corresponding author Cheng-Ming Chuong of the University of Southern California, Los Angeles. Some soar like eagles, while others require rapid flapping of wings like hummingbirds. Some birds, including ostriches and penguins, dont fly at all.

This picture shows a the asymmetric vane and tapering main shaft of a single flight feather from a goshawk. Credit: Hao Howard Wu and Wen Tau Juan

Such differences in flight styles are largely due to the characteristics of their flight feathers, Chuong adds. We wanted to learn how flight feathers are made so we can understand nature better and learn principles of bioinspired architecture.

In the new study, the researchers put together a multidisciplinary team to look at feathers in many different ways, from their biophysical properties to the underlying molecular biology that allows their formation from stem cells in the skin. They examined the feathers of flightless ostriches, short-distance flying chickens, soaring ducks and eagles, and high-frequency flying sparrows. They studied the extremes by including hummingbirds and penguins. To better understand how feathers have evolved and changed over evolutionary time, the team also looked to feathers that are nearly 100 million years old, found embedded and preserved in amber in Myanmar.

Based on their findings, the researchers explain that feathers modular structure allowed birds to adapt over evolutionary time, helping them to succeed in the many different environments in which birds live today. Their structure also allows for the specialization of feathers in different parts of an individual birds body.

The flight feather is made of two highly adaptable architectural modules: the central shaft, or rachis, and the peripheral vane. The rachis is a composite beam made of a porous medulla that keeps feathers light surrounded by a rigid cortex that adds strength. Their studies show that these two components of the rachis allow for highly flexible designs that enabled to fly or otherwise get around in different ways. The researchers also revealed the underlying molecular signals, including Bmp and Ski, that guide the development of those design features.

Attached to the rachis is the feather vane. The vane is the part of the feather made up of many soft barbs that zip together. The researchers report that the vane develops using principles akin to paper cutting. As such, a single epithelial sheet produces a series of diverse, branched designs with individual barbs, each bearing many tiny hooklets that hold the vane together into a plane using a Velcro-like mechanism. Their studies show that gradients in another signaling pathway (Wnt2b) play an important role in the formation of those barbs.

To look back in time, the researchers studied recently discovered amber fossils, allowing them to explore delicate, three-dimensional feather structures. Their studies show that ancient feathers had the same basic architecture but with more primitive characteristics. For instance, adjacent barbs formed the vane with overlapping barbules, without the Velcro-like, hooklet mechanism found in living birds.

Weve learned how a simple skin can be transformed into a feather, how a prototypic feather structure can be transformed into downy, contour, or flight feathers, and how a flight feather can be modulated to adapt to different flight modes required for different living environments, Chuong says. In every corner and at different morphological scales, we were amazed at how the elegant adaption of the prototype architecture can help different birds to adapt to different new environments.

The researchers say that, in addition to helping to understand how birds have adapted over time, they hope these bioinspired architectural principles theyve uncovered can be useful in future technology design. They note that composite materials of the future could contribute toward the construction of light but robust flying drones, durable and resilient wind turbines, or better medical implants and prosthetic devices.

Team co-leader and biophysicist Wen Tau Juan of the Integrative Stem Cell Center of China Medical University Hospital, Taiwan, has already begun to explore the application of feather-inspired architectural principles in bio-material design. The team also hopes to learn even more about the molecular signals that allow the formation of such complex feather structures from epidermal stem cells that all start out the same.

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Reference: The Making of a Flight Feather: Bio-architectural Principles and Adaptation by Wei-Ling Chang, Hao Wu, Yu-Kun Chiu, Shuo Wang, Ting-Xin Jiang, Zhong-Lai Luo, Yen-Cheng Lin, Ang Li, Jui-Ting Hsu, Heng-Li Huang, How-Jen Gu, Tse-Yu Lin, Shun-Min Yang, Tsung-Tse Lee, Yung-Chi Lai, Mingxing Lei, Ming-You Shie, Cheng-Te Yao, Yi-Wen Chen, J.C. Tsai, Shyh-Jou Shieh, Yeu-Kuang Hwu, Hsu-Chen Cheng, Pin-Chi Tang, Shih-Chieh Hung, Chih-Feng Chen, Michael Habib, Randall B. Widelitz, Ping Wu, Wen-Tau Juan and Cheng-Ming Chuong, 27 November 2019, Cell.DOI: 10.1016/j.cell.2019.11.008

This work was supported by the ISCC, CMUH, Taiwan, the Drug Development Center, CMU, Higher Education Sprout Project, Ministry of Education (HESP-MOE), and grants from the National Institutes of Health, Ministry of Science and Technology, Taiwan, iEGG/Avian Genetic Resource/ABC supported by HESP-MOE, the Human Frontier Science Program, the National Natural Science Foundation of China, NSFC, Academia Sinica Research Program on Nanoscience and Nanotechnology, Top Notch Project, NCKU, and a University Advancement grant by MOE, Taiwan.

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How Flight Feathers Evolved: Study of Chickens, Ostriches, Penguins, Ducks and Eagles - SciTechDaily

Researchers discover a stem cell therapy that can help heal injured heart – ANI News

ANI | Updated: Nov 29, 2019 20:58 IST

Washington D.C. [USA], Nov 29 (ANI): Researchers have discovered a stem cell therapy that might help the heart recuperate from an attack.This study published in the journal Nature reported that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.Mediated by macrophage cells of the immune system, the secondary healing process provided a modest benefit to heart function after a heart attack, according to the principal investigator Jeffery Molkentin, PhD, director of Molecular Cardiovascular Microbiology a Cincinnati Children's Hospital Medical Center and a professor of the Howard Hughes Medical Institute (HHMI)."The innate immune response acutely altered cellular activity around the injured area of the heart so that it healed with a more optimized scar and improved contractile properties," Molkentin said.The findings build on a 2014 study published by the same research team. As in that earlier study, the current paper shows that injecting c-kit positive heart stem cells into damaged hearts as a strategy to regenerate cardiomyocytes doesn't work.The findings prompted Molkentin and his colleagues to conclude that there is a need to "re-evaluate the current planned cell therapy based clinical trials to ask how this therapy might really work."Researchers worked with two types of heart stem cells currently used in the clinical trials -- bone marrow mononuclear cells and cardiac progenitor cells.As they went through the process of testing and re-verifying their data under different conditions, they were surprised to discover that in addition to the two types of stem cells, injecting dead cells or even an inert chemical called zymosan also provided benefit to the heart by optimizing the healing process. Zymosan is a substance designed to induce an innate immune response.They reported that stem cells or zymosan therapies tested in this study altered immune cell responses that significantly decreased the formation of extracellular matrix connective tissue in the injury areas, while also improving the mechanical properties of the scar itself.Researchers also found that stem cells and other therapeutic substances like zymosan have to be injected directly into the hearts surrounding the area of infarction injury."Most of the current trials were also incorrectly designed because they infuse cells into the vasculature. Our results show that the injected material has to go directly into the heart tissue flanking the infarct region. This is where the healing is occurring and where the macrophages can work their magic," Molkentin explained. (ANI)

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Researchers discover a stem cell therapy that can help heal injured heart - ANI News

Revolutionizing Injury Recovery With Tendon Stem Cells – Technology Networks

The buildup of scar tissue makes recovery from torn rotator cuffs, jumpers knee, and other tendon injuries a painful, challenging process, often leading to secondary tendon ruptures. New research led by Carnegies Chen-Ming Fan and published inNature Cell Biologyreveals the existence of tendon stem cells that could potentially be harnessed to improve tendon healing and even to avoid surgery.

Tendons are connective tissue that tether our muscles to our bones, Fan explained. They improve our stability and facilitate the transfer of force that allows us to move. But they are also particularly susceptible to injury and damage.

Unfortunately, once tendons are injured, they rarely fully recover, which can result in limited mobility and require long-term pain management or even surgery. The culprit is fibrous scars, which disrupt the tissue structure of the tendon.

Working with Carnegies Tyler Harvey and Sara Flamenco, Fan revealed all of the cell types present in the Patellar tendon, found below the kneecap, including previously undefined tendon stem cells.

Because tendon injuries rarely heal completely, it was thought that tendon stem cells might not exist, said lead author Harvey. Many searched for them to no avail, but our work defined them for the first time.

Stem cells are blank cells associated with nearly every type of tissue, which have not fully differentiated into a specific functionality. They can also self-renew, creating a pool from which newly differentiated cell types can form to support a specific tissues function. For example, muscle stem cells can differentiate into muscle cells. But until now, stem cells for the tendon were unknown.

Surprisingly, the teams research showed that both fibrous scar tissue cells and tendon stem cells originate in the same spacethe protective cells that surround a tendon. Whats more, these tendon stem cells are part of a competitive system with precursors of fibrous scars, which explains why tendon healing is such a challenge.

The team demonstrated that both tendon stem cells and scar tissue precursor cells are stimulated into action by a protein called platelet-derived growth factor-A. When tendon stem cells are altered so that they dont respond to this growth factor, then only scar tissue and no new tendon cells form after an injury.

Tendon stem cells exist, but they must outcompete the scar tissue precursors in order to prevent the formation of difficult, fibrous scars, Fan explained. Finding a therapeutic way to block the scar-forming cells and enhance the tendon stem cells could be a game-changer when it comes to treating tendon injuries.

Reference: Harvey, Flamenco and Fan. 2019.A Tppp3+Pdgfra+ tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis. Nature Cell Biology.DOI: https://doi.org/10.1038/s41556-019-0417-z.

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Revolutionizing Injury Recovery With Tendon Stem Cells - Technology Networks