Category Archives: Stell Cell Research


New Link Discovered Between Cells That Burn Fat and Colon Cancer – Clinical OMICs News

A new study by Rutgers University researchers suggests that two genes expressed in the intestinal cells that line the inside of the colon may also be involved in cancer development.

Recent studies have shown that intestinal stem cells can increase in animals on a high fat Western diet, potentially explaining an elevated cancer risk from such a diet.Diet being able to control cell proliferation is an interesting research development, particularly the convergence of dietary factors and dysregulated gene signaling driving malignant transformations and promoting an adenoma-to-adenocarcinoma progression.

This new study suggests a novel connection between HNF4A and HNF4G genes, diet and cancer.Genetic expression of HNF4 has previously been shown by to be heavily influenced by the gut microbiota, which in turn can influence a multitude of intestinal disorders.

Non-host gene regulation was further explored in this study by using a high fat diet to test how these genes work, and the researchers discovered they help co-regulate stem cell proliferation, as well as help intestine cells burn dietary fat. This was done by isolating cells from knockout and control mice and observing intestine stem cell proliferation under conditions of high fat and control. Mice that had both HNF4A and HNF4G knocked out were unable to have their stem cells proliferate under high fat conditions.

Intestinal stem cells undergo constant renewal and fuel the continuous turnover of the lining of the intestine. People naturally lose millions of intestinal cells daily, much like they lose skin cells. If this rate of replication is not closely controlled, it can quickly lead to malignancy. Lack of proliferation can be very problematic for the colon and damaging to lower layers of cells.

This [research] is important because scientists have shown that when theres too much dietary fat in the intestine, stem cell numbers increase, boosting susceptibility to colon cancer, said senior author Michael Verzi, an associate professor in the Department of Genetics in the School of Arts and Sciences at Rutgers UniversityNew Brunswick.

Rutgers scientists believe HNF4A and HNF4G help stem cells burn fat, providing them energy. By linking gene activation, cell replication number, diet and cancer risk, scientists might be able to better understand the cancer development process in high risk patients. Going forward, the researchers plan to continue studying whether these two genes alter stem cell numbers and cancer risk alongside a high fat diet, said Verzi.

Colorectal cancer (of the colon or rectum) is the third most common cancer diagnosed in both men and women in the United States. According to the American Cancer Society, over 100,000 Americans will be diagnosed with colon cancer this year. This cancer is also the second most deadliest in the United States, but due to a combination of increased screening and heightened awareness the death rate has been dropping. However, in patients under the age of 55, the death rate of colon cancer has increased each year by 1% since 2007. Approximately 50,000 colon cancer patients are expected to die in 2019.

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New Link Discovered Between Cells That Burn Fat and Colon Cancer - Clinical OMICs News

Systematic analysis and evaluation of Mesenchymal Stem Cells Market with share, growth rate, Forecasts to 2026 – WindStreetz

This Mesenchymal Stem Cells research study consists of the historical data from and forecasts till 2026. The report is created keeping in mind to make it a valuable source of information for market specialists in readily accessible documents. The documents are curated with clearly presented graphs and figures.

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The global mesenchymal stem cells market size to reach USD 2,518.5 Million by 2026, growing at a CAGR of 7.0% during forecast period, according to a new research report published by Alexa Reports Research. The report Mesenchymal Stem Cells Market, [By Source (Bone Marrow, Umbilical Cord Blood, Peripheral Blood, Lung Tissue, Synovial Tissues, Amniotic Fluids, Adipose Tissues); By Application (Injuries, Drug Discovery, Cardiovascular Infraction, Others); By Region]: Market Size & Forecast, 2018 2026 provides an extensive analysis of present market dynamics and predicted future trends. The market was valued at USD 1,335.1 million in 2017. In 2017, the drug discovery application dominated the market, in terms of revenue. North America region is observed to be the leading contributor in the global market revenue in 2017.

are adult stem cells, which are traditionally found in the bone marrow. However, they can also be parted from other available tissues including peripheral blood, cord blood, fallopian tube. These stem cells mainly function for the replacement of damaged cell and tissues. The potential of these cell is to heal the damaged tissue with no pain to the individual. Scientists are majorly focusing on developing new and innovative treatment options for the various chronic diseases like cancer. Additionally, the local governments have also taken various steps for promoting the use of these stem cells.

The significant aspects that are increasing the development in market for mesenchymal stem cells consist of enhancing need for these stem cells as an efficient therapy option for knee replacement. Raising senior populace throughout the world, as well as increasing frequency of numerous persistent conditions consisting of cancer cells, autoimmune illness, bone and cartilage diseases are elements anticipated to enhance the market development throughout the forecast period. The mesenchymal stem cells market is obtaining favorable assistance by the reliable federal government policies, as well as funding for R&D activities which is anticipated to influence the market growth over coming years. According to the reports released by world health organization (WHO), by 2050 individuals aged over 60 will certainly make up greater than 20% of the globes population. Of that 20%, a traditional quote of 15% is estimated to have symptomatic OA, as well as one-third of these individuals are expected to be influenced by extreme specials needs. Taking into consideration all these aspects, the market for mesenchymal stem cells will certainly witness a substantial development in the future.

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Increasing demand for better healthcare facilities, rising geriatric population across the globe, and continuous research and development activities in this area by the key players is expected to have a positive impact on the growth of Mesenchymal Stem Cells market. North America generated the highest revenue in 2017, and is expected to be the leading region globally during the forecast period. The Asia Pacific market is also expected to witness significant market growth in coming years. Developing healthcare infrastructure among countries such as China, India in this region is observed to be the major factor promoting the growth of this market during the forecast period.

The major key players operating in the industry are Cell Applications, Inc., Cyagen Biosciences Inc. Axol Bioscience Ltd., Cytori Therapeutics Inc., Stem cell technologies Inc., Celprogen, Inc. BrainStorm Cell Therapeutics, Stemedica Cell Technologies, Inc. These companies launch new products and undertake strategic collaboration and partnerships with other companies in this market to expand presence and to meet the increasing needs and requirements of consumers.

Alexa Reports Research has segmented the global mesenchymal stem cells market on the basis of source type, application and region:

Mesenchymal Stem Cells Source Type Outlook (Revenue, USD Million, 2015 2026)

Bone MarrowUmbilical Cord BloodPeripheral BloodLung TissueSynovial TissuesAmniotic FluidsAdipose Tissues

Mesenchymal Stem Cells Application Outlook (Revenue, USD Million, 2015 2026)

InjuriesDrug DiscoveryCardiovascular InfractionOthers

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About Us:Alexa Reports is a globally celebrated premium market research service provider, with a strong legacy of empowering business with years of experience. We help our clients by implementing decision support system through progressive statistical surveying, in-depth market analysis, and reliable forecast data. Alexa Reports is a globally celebrated premium market research service provider, with a strong legacy of empowering business with years of experience. We help our clients by implementing decision support system through progressive statistical surveying, in-depth market analysis, and reliable forecast data.

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Systematic analysis and evaluation of Mesenchymal Stem Cells Market with share, growth rate, Forecasts to 2026 - WindStreetz

New Device Permits a Closer Look at Previously Inaccessible Areas of the Genome – Technology Networks

Expansions of DNA repeats are very hard to analyze. A method developed by researchers at the Max Planck Institute for Molecular Genetics in Berlin allows for a detailed look at these previously inaccessible regions of the genome. It combines nanopore sequencing, stem cell, and CRISPR-Cas technologies. The method could improve the diagnosis of various congenital diseases and cancers in the future.

Large parts of the genome consist of monotonous regions where short sections of the genome repeat hundreds or thousands of times. But expansions of these "DNA repeats" in the wrong places can have dramatic consequences, like in patients with Fragile X syndrome, one of the most commonly identifiable hereditary causes of cognitive disability in humans. However, these repetitive regions are still regarded as an unknown territory that cannot be examined appropriately, even with modern methods.

A research team led by Franz-Josef Mller at the Max Planck Institute for Molecular Genetics in Berlin and the University Hospital of Schleswig-Holstein in Kiel recently shed light on this inaccessible region of the genome. Mller's team was the first to successfully determine the length of genomic tandem repeats in patient-derived stem cell cultures. The researchers additionally obtained data on the epigenetic state of the repeats by scanning individual DNA molecules. The method, which is based on nanopore sequencing and CRISPR-Cas technologies, opens the door for research into repetitive genomic regions, and the rapid and accurate diagnosis of a range of diseases.A gene defect on the X chromosomeIn Fragile X syndrome, a repeat sequence has expanded in a gene called FMR1 on the X chromosome. "The cell recognizes the repetitive region and switches it off by attaching methyl groups to the DNA," says Mller. These small chemical changes have an epigenetic effect because they leave the underlying genetic information intact. "Unfortunately, the epigenetic marks spread over to the entire gene, which is then completely shut down," explains Mller. The gene is known to be essential for normal brain development. He states: "Without the FMR1 gene, we see severe delays in development leading to varying degrees of intellectual disability or autism."

Female individuals are, in most cases, less affected by the disease, since the repeat region is usually located on only one of the two X chromosomes. Since the unchanged second copy of the gene is not epigenetically altered, it is able to compensate for the genetic defect. In contrast, males have only one X chromosome and one copy of the affected gene and display the full range of clinical symptoms. The syndrome is one of about 30 diseases that are caused by expanding short tandem repeats.

First precise mapping of short tandem repeats

In this study, Mller and his team investigated the genome of stem cells that were derived from patient tissue. They were able to determine the length of the repeat regions and their epigenetic signature, a feat that had not been possible with conventional sequencing methods. The researchers also discovered that the length of the repetitive region could vary to a large degree, even among the cells of a single patient.

The researchers also tested their process with cells derived from patients that contained an expanded repeat in one of the two copies of the C9orf72 gene. This mutation leads to one of the most common monogenic causes of frontotemporal dementia and amyotrophic lateral sclerosis. "We were the first to map the entire epigenetics of extended and unchanged repeat regions in a single experiment," says Mller. Furthermore, the region of interest on the DNA molecule remained physically wholly unaltered. "We developed a unique method for the analysis of single molecules and for the darkest regions of our genome - that's what makes this so exciting for me."

Tiny pores scan single molecules

"Conventional methods are limited when it comes to highly repetitive DNA sequences. Not to mention the inability to simultaneously detect the epigenetic properties of repeats," says Bjrn Brndl, one of the first authors of the publication. That's why the scientists used Nanopore sequencing technology, which is capable of analyzing these regions. The DNA is fragmented, and each strand is threaded through one of a hundred tiny holes ("nanopores") on a silicon chip. At the same time, electrically charged particles flow through the pores and generate a current. When a DNA molecule moves through one of these pores, the current varies depending on the chemical properties of the DNA. These fluctuations of the electrical signal are enough for the computer to reconstruct the genetic sequence and the epigenetic chemical labels. This process takes place at each pore and, thus, each strand of DNA.

Genome editing tools and bioinformatics illuminate "dark matter"Conventional sequencing methods analyze the entire genome of a patient. Now, the scientists designed a process to look at specific regions selectively. Brndl used the CRISPR-Cas system to cut DNA segments from the genome that contained the repeat region. These segments went through a few intermediate processing steps and were then funneled into the pores on the sequencing chip.

"If we had not pre-sorted the molecules in this way, their signal would have been drowned in the noise of the rest of the genome," says bioinformatician Pay Giesselmann. He had to develop an algorithm specifically for the interpretation of the electrical signals generated by the repeats: "Most algorithms fail because they do not expect the regular patterns of repetitive sequences." While Giesselmann's program "STRique" does not determine the genetic sequence itself, it counts the number of sequence repetitions with high precision. The program is freely available on the internet.

Numerous potential applications in research and the clinic"With the CRISPR-Cas system and our algorithms, we can scrutinize any section of the genome - especially those regions that are particularly difficult to examine using conventional methods," says Mller, who is heading the project. "We created the tools that enable every researcher to explore the dark matter of the genome," says Mller. He sees great potential for basic research. "There is evidence that the repeats grow during the development of the nervous system, and we would like to take a closer look at this."

The physician also envisions numerous applications in clinical diagnostics. After all, repetitive regions are involved in the development of cancer, and the new method is relatively inexpensive and fast. Mller is determined to take the procedure to the next level: "We are very close to clinical application."

Reference: Giesselmann et al. 2019.Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing. Nature Biotechnology.DOI: https://doi.org/10.1038/s41587-019-0293-x.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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New Device Permits a Closer Look at Previously Inaccessible Areas of the Genome - Technology Networks

Omega 3 Fatty Acid Health Welfare Connected To Stem Cell Regulation Researchers Discover – News Raise

Omega 3 fatty acid health welfare connected to stem cell regulation researchers discover. For years researchers have acknowledged that imperfections in a former cellular antenna known as the primary cilium are connected to obesity and insulin aversion. Presently researchers at the Stanford University School of Medicine have found that the peculiar minuscule cellular attachment is discerning omega 3 fatty acids in the food and that this gesticulation is in a beeline impacting how stem cells in fat tissue splinter and convert into fat cells.

The discovery constitutes an absent connection between two worlds that of dietary science and that of molecular and cellular biology. Dietary studies have long ago discovered that the expending of omega 3 fatty acids crucial fatty acids customary in fish and nuts is linked with lesser of heart disease, stroke, arthritis, and even depression.

Researchers in Jacksons lab was not observing omega 3s when they commenced their research. They were observing the gesturing molecule that fat stem cells were discerning. The molecule could have been anything gesturing trail in cellular biology frequently include esoteric molecules handful of people have listened to. They were aware of the fact that uncommon illnesses including a deficiency in the primary cilium, people are often hungry and cannot put a halt to consuming and thereby become obese and insulin unaffected by. So they were taken aback when the signal flipped out to be omega 3 fatty acids.

Steve Lopez is the Editorial Page Editor for News Raise. He covers Health. He has won more than a dozen national journalism awards for his reporting and column writing at seven newspapers and four news magazines.

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Omega 3 Fatty Acid Health Welfare Connected To Stem Cell Regulation Researchers Discover - News Raise

Tokyo’s Heartseed reaps $26M to test its stem cell injections for heart failure – FierceBiotech

Tokyo-based Heartseed has raised 2.8 billion yen, or about $26 million U.S., to help develop its stem cell-based treatment for heart failure.

The company has its eyes on two clinical trials, set to start in the next year: an investigator-initiated study through its research partner Keio University in dilated cardiomyopathy, followed by a phase 1/2 trial in late 2020 for heart failure with reduced left ventricular ejection fraction.

Heartseeds treatment differs in approach from other, similar therapies using induced pluripotent stem cells (iPSCs), where sheets of cells are grafted onto the surface of the heart to improve vascularization and blood flow.

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Instead, the company forms spherical clusters of heart cells from purified, allogeneic iPSCs, which are injected directly into the heart muscle wall. As they grow and electrically sync with other cells within the myocardium, Heartseed expects to see improvements in the strength of contractions.

The companys series B round included new investors SBI Investment, JMDC, Gene Techno Science, Nissay Capital and SMBC Capital as well as Astellas Venture Management, returning from Heartseeds series A raise. The latest proceeds bring its total funding to 3.8 billion yen, or about $35 million.

RELATED: Growing transplantable arteries from stem cells

Heartseed was founded in 2015 through the research of its CEO, Keiichi Fukuda, a professor in the department of cardiology at Keio University, and his teams work in regenerative medicine and cell production, purification and delivery.

We are grateful for the support of our investors, which I believe is a reflection of their expectation and confidence that our lead pipeline HS-001 can be a curative therapy for severe HF, with the mechanism that transplanted ventricular-specific highly-purified cardiomyocytes engraft to patients heart and retain for a long-term, Fukuda said in a statement.

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Tokyo's Heartseed reaps $26M to test its stem cell injections for heart failure - FierceBiotech

Junior Research Fellow for Stem Cell-Based Neural Tissue Engineering Project job with VELLORE INSTITUTE OF TECHNOLOGY | 187070 – Times Higher…

Job Description

Junior Research Fellow (JRF)for Translational Research - Stem Cell-based Neural Tissue Engineering Project:

Title of the Project: Human dental pulp stem cells as a multifaceted tool for accelerating neural regenerationDuration: 3 YearsLocation: Vellore Institute of Technology, Vellore

Qualification:

M.Sc/ M. Tech (Biomaterials, Tissue Engineering, Biotechnology, Biology, and Biomedical Sciences) with a minimum of 55% marks.

Skill set required:

Candidate with work experience in biomaterial synthesis, scaffold fabrication and stem cell culture is desirable.

Stipend: Rs.20,000/- per month (consolidated)

Work functions of the JRF: The JRF will be required to do full time research related to this specific project, in particular biomaterial synthesis and characterization, scaffold fabrication, biological assays, dental stem cell culture.

Principal Investigator:

Dr.Murugan RamalingamCentre for Biomaterials, Cellular and Molecular Theranostics (CBCMT)School of Mechanical EngineeringVellore Institute of Technology (VIT),Vellore 632014

Send your resume along with relevant documents pertaining to the details of qualifications, experience and latest passport size photo on or before (30/11/2019) through online http://careers.vit.ac.in.

No TA and DA will be paid for appearing for the interview.

Shortlisted candidates will be called for an interview at a later date which will be intimated by email.

Salary:Not Disclosed by RecruiterIndustry:Education / Teaching / TrainingFunctional Area:Teaching, Education, Training, CounsellingRole:Trainee

Keyskills

stem cellsbiotechnologybiologybiomaterials

Desired Candidate Profile

Please refer to the Job description above

Education-

UG:B.Tech/B.E. - Bio-Chemistry/Bio-Technology, Biomedical, B.Sc - BiologyPG:M.Tech - Bio-Chemistry/Bio-Technology, Biomedical, MS/M.Sc(Science) - Biotechnology, Biology

Company Profile

Vellore Institute of Technology

VIT was established with the aim of providing quality higher education on par with international standards. It persistently seeks and adopts innovative methods to improve the quality of higher education on a consistent basis.The campus has a cosmopolitan atmosphere with students from all corners of the globe. Experienced and learned teachers are strongly encouraged to nurture the students.

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Junior Research Fellow for Stem Cell-Based Neural Tissue Engineering Project job with VELLORE INSTITUTE OF TECHNOLOGY | 187070 - Times Higher...

CRISPR Therapeutics and Vertex: Promising Gene Therapy Data for Sickle Cell Disease and Beta Thalassemia – BioSpace

CRISPR Therapeutics and Vertex Pharmaceuticals announced positive interim data from the first two patients in the companies ongoing Phase I/II clinical trials of its CRISPR/Cas9 gene-editing therapy CTX001.

One of the patients with transfusion-dependent beta thalassemia (TDT) was treated with CTX001 in the first quarter of 2019. The data reflects nine months of safety and efficacy follow-up.

The second patient has severe sickle cell disease (SCD) and received CTZX001 in mid-2019. The interim data is for four months of safety and efficacy follow-up.

For the treatment, patients have hematopoietic stem and progenitor cells collected from their peripheral blood. The cells are then edited using CRISPR/Cas9. The edited cells, which are called CTX001, are then infused back into the patient as part of a stem cell transplant.

The TDT patient prior to the treatment required 16.5 transfusions per year. After treatment, the patient achieved neutrophil engraftment 33 days after CTX001 infusion and platelet engraftment 37 days after infusion. There were two serious adverse events, but the principal investigator did not believe they were related to CTX001. One was pneumonia in the presence of neutropenia and veno-occlusive liver disease associated to busulfan conditioning, which is part of a stem cell transplant used to destroy the original bone marrow that has the mutation in it.

Nine months after CTX001 infusion, the patient was transfusion independent. Total hemoglobin levels were 11.9 g/dL, 10.1 g/dL fetal hemoglobin, and 99.8% F-cells.

The SCD patient had seven vaso-occlusive crises (VOCs) annually. Thirty days after CTX001 infusion, the patient reached neutrophil and platelet engraftment. This patient had three severe adverse events, none of which the principal investigator believed were related to CTX001. They were sepsis in the presence of neutropenia, cholelithiasis, and abdominal pain. All resolved. Four months after treatment, the patient was free of VOCs and had total hemoglobin levels of 11.3 g/dL, 46.6% fetal hemoglobin, and 94.7% F-cells.

The data we announced today are remarkable and demonstrate that CTX001 has the potential to be a curative CRISPR/Cas9-based gene-editing therapy for people with sickle cell disease and beta thalassemia, said Jeffrey Leiden, chairman, president and chief executive officer of Vertex. While the data are exciting, we are still in the early phase of this clinical program. We look forward to continuing to work with physicians, patients, caregivers and families over the coming months and years to bring forward the best possible therapy for these two serious diseases and to continue to accelerate our gene-editing programs for other serious diseases such as Duchenne muscular dystrophy and myotonic dystrophy type 1.

These data are very strong evidence of the promise of CRISPR treatments that could potentially cure diseases. CRISPR and Vertex are not the first, however. Bluebird Bio received approval in Europe for its gene therapy, Zynteglo, for transfusion-dependent beta-thalassemia. It uses a different approach than Vertex and CRISPR Therapeutics, and it does not work in all patients. A decision by the U.S. Food and Drug Administration (FDA) is expected in 2020. The therapy has a price tag of about $1.75 million spread over a five-year installment plan.

Mitchell Weiss of St. Jude Childrens Research Hospital, told STAT, that after years of sickle cell research neglect, these new approaches represented a perform storm. For decades, we knew about the sickle cell disease mutations, but we didnt know about other genes [involved in the disease] and we didnt have the necessary tools for genetic correction of blood-making stem cells. Now we have a confluence of scientific understanding and technology that can come together to make things happen.

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CRISPR Therapeutics and Vertex: Promising Gene Therapy Data for Sickle Cell Disease and Beta Thalassemia - BioSpace

Europe Stem Cell Assay Market to Witness a Pronounce Growth in Coming Years | Insights, Trends, Growth, Industry Drivers with Cellular Dynamics…

The Europe stem cell assay market is expected to grow US$793 million by 2027. The market growth is expected at the CAGR of +22% in the forecast period.

Stem cells have a remarkable potential to develop into different types of cells and are involved in the internal repair system of the body. Stem cell assays are the techniques for analyzing the living cells on the parameters of shape, size, besides others with the aim to measure the biochemical and cellular functioning of the cells. Such properties make the stem cell assays to be extensively utilized in industrial practices of drug development. The growing biotechnology sector and increasing global burden of diseases like cancer, diabetes, and others are estimated to be the major drivers for the Europe Stem Cell Assay Market growth during the forecast period.

The latest report entitled Europe Stem Cell Assay Market from 2019 to 2027 has been recently added to the repository of report consultants. It encircles the evaluation made on the basis of key competitors who are showing active participation in determining how the market actually works. They have achieved great success in understanding what the expectations of their applications are and what the anticipated trends that may show up in the future.

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Top Key Players Covered in Europe Stem Cell Assay Market:

Cellular Dynamics International (Holding Company Fujifilm), Cell Bio Labs, Inc., Corning Inc., Hemogenix Inc., Promega Corporation, Thermo Fisher, Stem Cell Technologies, Fibrocell Science Inc., Becton Dickinson, Stryker Corporation, Takara Holdings Inc., R&D Systems, Bio-Rad, GE Healthcare and Merck Millipore (holding company is Merck KGaA).

The Europe stem cell assay market by geography is segmented into the UK, France, Germany, Spain, Italy and Rest of Europe. Increasing Adoption of Stem Cell Assay, improvement in the Technology, high expense in Stem Cell Research is the major drivers for the market growth in the Europe region. The rise in the adoption of stem cell assay for drug screening & testing is one of the major reasons driving the industry research

Market Segmentation:

Europe Stem Cell Assay Market by Type:

Europe Stem Cell Assay Market by Application:

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Key highlights of the Europe Stem Cell Assay Market for the forecast years 2019-2026:

It has been accumulated through a couple of research methodologies such as primary and secondary research. The Europe Stem Cell Assay Market data has been observed through industry-specific analysis tools like SWOT and Porters five techniques. This informative data has been gathered through reliable sources such as press releases, websites, interviews, and statistical surveys.

In This Study, The Years Considered To Estimate The Size Of Europe Stem Cell Assay Market Are As Follows:

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Stem Cell And Regenerative Therapy Market Value Share, Analysis and Segments 2018-2024 – Crypto News Byte

The globalstem cell and regenerative medicines marketshould grow from $21.8 billion in 2019 to reach $55.0 billion by 2024 at a compound annual growth rate (CAGR) of 20.4% for the period of 2019-2024.

Report Scope:

The scope of this report is broad and covers various type of product available in the stem cell and regenerative medicines market and potential application sectors across various industries. The current report offers a detailed analysis of the stem cell and regenerative medicines market.

The report highlights the current and future market potential of stem cell and regenerative medicines and provides a detailed analysis of the competitive environment, recent development, merger and acquisition, drivers, restraints, and technology background in the market. The report also covers market projections through 2024.

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The report details market shares of stem cell and regenerative medicines based on products, application, and geography. Based on product the market is segmented into therapeutic products, cell banking, tools and reagents. The therapeutics products segments include cell therapy, tissue engineering and gene therapy. By application, the market is segmented into oncology, cardiovascular disorders, dermatology, orthopedic applications, central nervous system disorders, diabetes, others

The market is segmented by geography into the following regions: North America, Europe, Asia-Pacific, South America, and the Middle East and Africa. The report presents detailed analyses of major countries such as the U.S., Canada, Mexico, Germany, the U.K. France, Japan, China and India. For market estimates, data is provided for 2018 as the base year, with forecasts for 2019 through 2024. Estimated values are based on product manufacturers total revenues. Projected and forecasted revenue values are in constant U.S. dollars, unadjusted for inflation.

Report Includes:

28 data tables An overview of global markets for stem cell and regenerative medicines Analyses of global market trends, with data from 2018, estimates for 2019, and projections of compound annual growth rates (CAGRs) through 2024 Details of historic background and description of embryonic and adult stem cells Information on stem cell banking and stem cell research A look at the growing research & development activities in regenerative medicine Coverage of ethical issues in stem cell research & regulatory constraints on biopharmaceuticals Comprehensive company profiles of key players in the market, including Aldagen Inc., Caladrius Biosciences Inc., Daiichi Sankyo Co. Ltd., Gamida Cell Ltd. and Novartis AG

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Summary

The global market for stem cell and regenerative medicines was valued at REDACTED billion in 2018. The market is expected to grow at a compound annual growth rate (CAGR) of REDACTED to reach approximately REDACTED billion by 2024. Growth of the global market is attributed to the factors such as growingprevalence of cancer, technological advancement in product, growing adoption of novel therapeuticssuch as cell therapy, gene therapy in treatment of chronic diseases and increasing investment fromprivate players in cell-based therapies.

In the global market, North America held the highest market share in 2018. The Asia-Pacific region is anticipated to grow at the highest CAGR during the forecast period. The growing government funding for regenerative medicines in research institutes along with the growing number of clinical trials based on cell-based therapy and investment in R&D activities is expected to supplement the growth of the stem cell and regenerative market in Asia-Pacific region during the forecast period.

Reasons for Doing This Study

Global stem cell and regenerative medicines market comprises of various products for novel therapeutics that are adopted across various applications. New advancement and product launches have influenced the stem cell and regenerative medicines market and it is expected to grow in the near future. The biopharmaceutical companies are investing significantly in cell-based therapeutics. The government organizations are funding research and development activities related to stem cell research. These factors are impacting the stem cell and regenerative medicines market positively and augmenting the demand of stem cell and regenerative therapy among different application segments. The market is impacted through adoption of stem cell therapy. The key players in the market are investing in development of innovative products. The stem cell therapy market is likely to grow during the forecast period owing to growing investment from private companies, increasing in regulatory approval of stem cell-based therapeutics for treatment of chronic diseases and growth in commercial applications of regenerative medicine.

Products based on stem cells do not yet form an established market, but unlike some other potential applications of bioscience, stem cell technology has already produced many significant products in important therapeutic areas. The potential scope of the stem cell market is now becoming clear, and it is appropriate to review the technology, see its current practical applications, evaluate the participating companies and look to its future.

The report provides the reader with a background on stem cell and regenerative therapy, analyzes the current factors influencing the market, provides decision-makers the tools that inform decisions about expansion and penetration in this market.

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Stem Cell And Regenerative Therapy Market Value Share, Analysis and Segments 2018-2024 - Crypto News Byte

Global Stem Cell Antibody Market: Key companies Profile, their market Share and other important parameters – Market Research Reporting

The global Stem Cell Antibody market is valued at million US$ in 2018 is expected to reach million US$ by the end of 2025, growing at a CAGR of during 2019-2025.

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This report focuses on Stem Cell Antibody volume and value at global level, regional level and company level. From a global perspective, this report represents overall Stem Cell Antibody market size by analyzing historical data and future prospect. Regionally, this report focuses on several key regions: North America, Europe, China and Japan.

Key companies profiled in Stem Cell Antibody Market report are Thermo Fisher Scientific, Inc. (U.S.), Merck Group (Germany), Abcamplc (U.K.), Becton, Dickinson and Company (U.S.), Bio-Rad Laboratories, Inc. (U.S.), Cell Signaling Technology, Inc. (U.S.), Agilent Technologies, Inc. (U.S.), F. Hoffmann-La Roche Ltd (Switzerland), Danaher Corporation (U.S.), GenScript (U.S.), PerkinElmer, Inc. (U.S.), Lonza (Switzerland), and BioLegend, Inc. (U.S.) and more in term of company basic information, Product Introduction, Application, Specification, Production, Revenue, Price and Gross Margin (2014-2019), etc.

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Table of Content

1 Stem Cell Antibody Market Overview

2 Global Stem Cell Antibody Market Competition by Manufacturers

3 Global Stem Cell Antibody Production Market Share by Regions

4 Global Stem Cell Antibody Consumption by Regions

5 Global Stem Cell AntibodyProduction, Revenue, Price Trend by Type

6 Global Stem Cell Antibody Market Analysis by Applications

7 Company Profiles and Key Figures in Stem Cell Antibody Business

8 Stem Cell Antibody Manufacturing Cost Analysis

9 Marketing Channel, Distributors and Customers

10 Market Dynamics

11 Global Stem Cell Antibody Market Forecast

12 Research Findings and Conclusion

13 Methodology and Data Source

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Global Stem Cell Antibody Market: Key companies Profile, their market Share and other important parameters - Market Research Reporting