New insights in stem cell therapy – Research Matters

Undoubtedly, ageing is a medically relevant phenomenon far too complicated to understand under the given laboratory conditions. Despite the human genome being available now for almost two decades, even the remotest possibility to delay, let alone halt the ageing-related diseases has been hard to come by. Scientists around the world are trying to demystify this biological enigma, and one such attempt has been made by researchers at Savitribai Phule Pune University.

In a recent study led by Dr Geetanjali Tomar of Savitribai Phule Pune University, the researchers explored if mesenchymal stem cells derived from gingiva, or gum, tissues (Gingiva-derived Mesenchymal Stem Cells or GMSCs) of a human donor can be used to repair tissues or control the immune response in the human body. Mesenchymal stem cells are a type of stem cell that can potentially transform into any kind of cell in the body. One of the key challenges to using such tissues was how the donors age affects the growth, physical characteristics and their potential to form different types of body cells an important indicator of any stem cells. The researchers found that the donors age does not affect these factors.

The use of human gingival tissues as stem cells has gained traction over the past decade because they are easier to harvest, easy for a donor to donate and have a relatively high yield. But whether these tissues can function as stem cells for therapy involving tissue regeneration and immunoregulation was a question that has remained elusive so far.

The researchers divided the gingival tissues into three groups based on donor age: group A (1331 years), group B (3755 years), and group C (5980 years). Both quality and quantity of mesenchymal stem cells from other tissues, including bone marrow, fat tissue, and other supporting tissues surrounding the teeth, are known to be affected by the donors age. However, the researchers found that the donors age does not affect the quality or quantity of the GMSCs, a property that could be leveraged for treating diseases.

One of the important characteristics of stem cells is how they look physically, especially when taken outside the body and grown under laboratory conditions. The study indicated that donor age did not affect the physical property of these cells. All the harvested cells maintained their biological nature to form supporting tissues and efficiently formed colonies or aggregates of cells necessary for stem cell function.

Surface markers are special types of proteins expressed on the surface of cells that help identify and isolate particular groups of stem cells. The current study found that GMSCs from all age groups expressed these surface markers without contamination from other kinds of cells.

A key challenge in using stem cells is that the ageing of the donor depletes the pool of stem cells and results in a significant reduction in their function. This process is referred to as senescence. The current study found that the GMSCs from young donors tend to progress faster towards ageing, while adult GMSCs tend to have a reduced rate of ageing in the laboratory. These results were interesting in the sense that somehow the adult GMSCs have a built-in mechanism to get rid of senescent cells and maintain a healthy pool of stem cells. The researchers also saw an increased level of biological indicators that point to increased cell senescence by either cell death or cell self-destruction.

The findings related to senescence were further supported by increased expression of a gene responsible for preventing cell multiplication in the adult GMSCs (group C), indicating that the cell had an efficient mechanism of avoiding DNA damage and reduced chances of senescence-associated tumour formation. GMSCs also promote the expression of growth factors that compensates for the senescence-induced cell population decline or any other ageing-associated stress conditions. This is an efficient mechanism to maintain stable tissue conditions and a healthy stem pool in the gingival tissue.

This maintenance of tissue homeostasis is also aided by cell migration (directed movement of a single cell or cell population) to maintain a healthy stem cell pool. The study found that the donors age does not significantly affect the movement of cells to the site of damage, indicating that the growth and physical characteristics of GMSCs remained largely unaffected by the donors age.

The researchers then looked at the functional characterization of these GMSC in terms of whether these stem cells can grow into different cell types. The study showed that these GMSCs are favourably transformed into neuronal cells, but transformation into cells that could form fat cells or bone cells was less favoured. This ability to form different types of cells was not dependent on the age of the donor, though researchers did find that some stages of forming bone tissue, such as the formation of supporting tissue and mineralization, did decline with age.

To test the therapeutic potential of GMSCs, the researchers wanted to understand whether these cells exhibit any behaviour that can change the bodys immune system either activate or suppress it. They found that GMSCs can potentially change how the immune system behaves. However, the immunosuppressive behaviour of the GMSCs declined with their age. However, the results were not significant enough, so the GMSCs could still be said to modify the immune system.

GMSCs and SARS-CoV2

The researchers then tried to mimic the conditions of lungs when exposed to SARS-CoV-2, characterised mostly by lung inflammation, infiltration of neutrophils (a kind of blood cell that helps fight infection), and increased expression of inflammatory cytokines. Under such conditions, the researchers found that the administration of GMSCs significantly reduced neutrophils in induced acute lung infection, indicating their high immunosuppressive behaviour. These results also corroborated with the reduction of other potential markers of tissue inflammation necessary to prevent cell growth and tumour prevention.

The administration of GMSCs from all age groups of donors was found to improve almost all parameters of lung injury, indicating that if these GMSCs were implemented for stem cell therapy in human patients, it would significantly improve the overall lung conditions.

While a single dose of GMSCs administration was followed in the study, the researchers do suggest that multiple rounds of administration followed by more extended observation periods could provide better insights into the age-related immunoregulatory and regenerative behaviour of GMSCs. This immunomodulatory behaviour of GMSCs could be a potential treatment for SARS-CoV-2-induced lung damage, particularly in the aged population. However, to achieve such a realisation, more experiments followed by large-scale clinical trials would be needed.

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New insights in stem cell therapy - Research Matters

Secrets of Permanent Blindness Revealed by Stem-cell Research – The Epoch Times

Research into the retina and optic nerve using stem-cell models has unveiled specific genetic markers of glaucomathe worlds leading cause of permanent blindness possibly opening up new treatments for the condition.

Glaucoma is a blanket term describing a group of eye conditions that do damage to the retinal ganglion cellsneurons near the inner eye that make up the optic nerve. The optic nerve is the part of the eye that receives light and transmits it to the brain; thus, the damage that glaucoma does leads to permanent blindness. Thecondition is predicted to affect around 80 million people by 2040, yet treatments are extremely limited.

This study linked 97 genetic clusters to the damage done by the most common form of glaucoma, primary open-angle glaucoma or POAG, revealing important genetic components that control the way the condition attacks. POAG is a genetically complicated condition that is likely hereditary and, at the moment, cannot be stopped or reversed. The only treatment of POAG available involves releasing pressure on the eye, and this will only slow down the condition.

The research project was led jointly by the Garvan Institute of Medical Research, the University of Melbourne, and the Centre for Eye Research Glaucoma.

We saw how the genetic causes of glaucoma act in single cells, and how they vary in different people, said joint lead author of the study and Melbourne University academic, Prof. Joseph Powell, in a Garvan Institutemedia release.

Current treatments can only slow the loss of vision, but this understanding is the first step towards drugs that target individual cell types, Powell said.

The research behind the discoverywas published in the journalCell Genomicsand wasthe result of a lengthy collaboration between Australian medical research centres involving the investigation of complicated diseases and their underlying genetic causes, using stem-cell modelling; which the researchers said demonstrated the success of this study and the power of this approach.

Previously, glaucoma research was limited because samples of the optic nerve could not be obtained from participants in a non-invasive fashion. However, stem-cell modelling addressed this issue as it allowed researchers to develop optic nerve samples from skin, a much easier part of the body to extract.

The team administered skin biopsies on183 participants, 91 of whom had advanced primary open-angle glaucoma, to gather skin cells that they could reprogram to revert into stem cells and then guide into becoming retinal cells. Of the 183 samples collected, 110 samples, 54 from participants with POAG, were successfully converted from skin cells into retinal, and over 200,000 of these converted cells were sequenced to generate molecular signatures.

The researchers of this study employedsingle-cell RNA genetic sequencing in order to study individual cells. This form of sequencing creates an incredibly detailed genetic map, which looks for genetic variations that affect the expressionthe process of turning instructions from DNA into functional products like proteins of one or more genes. Through identifying these key genes, further deductions on the influence that genetic variations have on glaucoma can be made.

The signatures of those with and without glaucoma were compared to establish key genetic components that control the way that glaucoma attacks the retina.

The researchers first identified, using the signatures of both those with and without glaucoma,312 genetic variants associated with the ganglion cells that eventually degenerate in a person living with POAG. Further analysis of the genes associated with POAG linked the 97 clusters mentioned above to the damage done by glaucoma.

Another joint-lead author of the paper and Melbourne University professor, Alice Pebay, said that by studying glaucoma in retinal cells, a context-specific profile of the disease was created.

We wanted to see how glaucoma acts in retinal cells specificallyrather than in a blood sample, for instanceso we can identify the key genetic mechanisms to target, Pebay said.

Equally, we need to know which genetic variations are healthy and normal, so we can exclude them from a treatment.

To improve the understanding of complex conditions such as glaucoma, researchers noted it was important to establish a profile of the disease which promotesthe understanding of causes, risks and fundamental mechanisms of diseases. Furthermore, genetic investigations are critical to drug development and pre-clinical trials because they assist in constructing complete human models of diseases.

University of Tasmania professor and a third joint-lead author of the paper,Alex Hewitt said that the findings of this study set up future research into novel glaucoma treatments.

Not only can scientists develop more tailored drugs, but we could potentially use the stem-cell models to test hundreds of drugs in pre-clinical assays, said Hewitt.

This method could also be used to assess drug efficacy in a personalised manner to assess whether a glaucoma treatment would be effective for a specific patient.

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Secrets of Permanent Blindness Revealed by Stem-cell Research - The Epoch Times

Animal Stem Cell Therapy Market projected CAGR of 5.2% for the next ten years (2022-2032) Persistence Market Research – GlobeNewswire

New York, June 27, 2022 (GLOBE NEWSWIRE) -- The global animal stem cell therapy market recorded sales of around US$ 249.9 Mn in 2021 and the market is predicted to experience healthy growth over the years ahead at a CAGR of 5.2% (2022 to 2032).

Animal stem cell therapies are treatments for disorders such as arthritis, soft tissue injuries, traumatic fractures, tendonitis, inflammatory bowel disease, and others that are given to animals. Hematopoietic stem cells and mesenchymal stem cells are used in these treatment procedures.

As the focus on giving animals a better quality of life grows, so does the adoption of such therapies across the world. The market for animal stem cell therapy is predicted to continuously increase owing to the growing need for higher levels of veterinary care.

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Regulatory bodies are also encouraging veterinary regenerative medicine research & development.

The European Commission has approved a few stem cell-based products within the region.

The animal stem cell therapy market is moderately fragmented with a few key market players and presents numerous opportunities for new market entrants to create a foothold in the industry. Increased pet adoption rate can be a beneficial factor for manufacturers of stem cells to expand into emerging markets.

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Key Takeaways from Market Study

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With rising disposable incomes and higher adoption rate of pet animals, the global market for animal stem cell therapy is set to gain traction over the coming years, says an analyst of Persistence Market Research.

Market Competition

Key animal stem cell therapy providers are investing in innovating veterinary regenerative medicines and they are also coming up with new product launches for the well-being of animals.

Along with product innovation, market players are also aiming for various collaborations to strengthen their R&D in the field of animal stem cell therapy.

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What Does the Report Cover?

Persistence Market Research offers a unique perspective and actionable insights on the animal stem cell therapy market in its latest study, presenting historical demand assessment of 2012 2021 and projections for 2022 2032.

The research study is based on product type (hemopoietic stem cells and mesenchymal stem cells), source (allogeneic and autologous), indication (osteoarthritis, soft tissue injuries, traumatic fractures, tendonitis, inflammatory bowel disease, and others), species (canine, feline, and equine), and end user (veterinary hospitals, veterinary clinics, and veterinary research institutes), across seven key regions of the world.

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Animal Stem Cell Therapy Market projected CAGR of 5.2% for the next ten years (2022-2032) Persistence Market Research - GlobeNewswire

‘A new Alzheimer’s treatment is on the horizon’: Cell therapy reverses dementia-like syndrome in dogs – BioPharma-Reporter.com

The biotechs all new neurorestorative approach aims to rebuild and replace lost brain cells in Alzheimers that underlies clinical symptoms.

On the back of the trial, the company plans to launch a world-first human trial in 2024.

The veterinary trial, led by Skin2Neuron and published this month in Stem Cell Research and Therapy, reversed the dementia-like syndrome that strikes down many older pet dogs with Alzheimers.

Dementia was reversed in more than half of the canine patients, with a clinically meaningful improvement in 80%. Typically, improvement lasted around two years.

Skin2Neuron champions its new approach as a ray of hope for Alzheimers disease: championing a completely different approach to the amyloid hypothesis of Alzheimers disease.

Our target is the ultimate cause of dementia: lost neurons and synapses. We do this by microinjecting a patients own HFN cells directly into the hippocampus, the brains memory center and first area to be devastated by Alzheimers, explains the company.

While its lead therapeutic target is Alzheimers, it says its technology also has potential to treat neurodegenerative conditions such as Parkinsons disease, Amyotrophic Lateral Sclerosis and more.

A dogs thinking neocortex and hippocampus is similar to the human brain, says the company. Meanwhile, older dogs often develop a dementia syndrome similar to human dementia: becoming forgetful, irritable, lost, wandering around aimlessly, failing to recognize owners and experiencing disrupted sleep.

"Because of deep parallels between the canine brain and human brain, and canine Alzheimer's and human Alzheimer's, I started this trial 10 years ago with the assumption that if it's going to work in humans, then it needs to work in dogs first. And the results exceeded my wildest expectations, said co-founder Professor Michael Valenzuela.

"The hippocampus, the memory center of the brain, was packed with baby neurons and new synapses, precisely where we delivered the cells. Compared to untreated dogs, it was like night and day".

Microscopic analysis confirmed the dogs had classic Alzheimer pathology: meaning the cell therapy worked in the setting of natural disease, a first of its kind, according to the company.

"Given our doggie patients also had many of the same health issues that older people face, it gives me even greater confidence," said Valenzuela.

Study:Valenzuela, M., Duncan, T., Abey, A.et al.Autologous skin-derived neural precursor cell therapy reverses canine Alzheimer dementia-like syndrome in a proof of concept veterinary trial.Stem Cell Res Ther13,261 (2022). https://doi.org/10.1186/s13287-022-02933-w

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'A new Alzheimer's treatment is on the horizon': Cell therapy reverses dementia-like syndrome in dogs - BioPharma-Reporter.com

Satellos Bioscience pursues a revolutionary approach to treat muscle degeneration, give new hope to patients and parents – Financial Post

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The company is developing a pill that causes stem cells to regenerate muscle to battle debilitating Duchenne muscular dystrophy

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By Richard Dal Monte

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Raising children is full of surprises like the time your toddler takes their first step, or the day your preschooler starts speaking in rhyme. As pleasant as these moments might be, there are tragic and frightening surprises that parents never see coming.

Duchenne muscular dystrophy (DMD), is one such surprise.

A rare genetic disease afflicting boys its found in about six per 100,000 individuals in North America and Europe, and symptoms usually present between two and three years of age DMD causes progressive muscle degeneration and weakness due to a non-functional protein called dystrophin, which helps keep muscle cells intact.

While existing treatments have helped extend life expectancy for people with DMD from their teens into their 20s and 30s, they are only temporary and dont address a critical issue: the inability of the muscles to regenerate.

Satellos Bioscience Inc. (TSXV: MSCL), a Canadian biotechnology company, is advancing game-changing science in skeletal muscle regeneration to improve the quality and duration of patients lives.

Our notion is that if we can restore muscle repair, well significantly reduce the severity and the progression of the disease

Michael Rudnicki, OC, PhD, co-founder and chief scientific officer, Satellos Bioscience Inc.

The key to slowing the progression of DMD is muscle regeneration

Founded in 2018 by biotech entrepreneurs Frank Gleeson and Michael Rudnicki, Satellos work is based on the research of Rudnicki, a senior scientist and the director of the Regenerative Medicine Program and the Sprott Centre for Stem Cell Research at the Ottawa Hospital Research Institute as well as a professor in the Department of Medicine at the University of Ottawa and CEO and scientific director of the Canadian Stem Cell Network.

The companys vision is to invent and develop medicines that reset the bodys innate ability for self-repair, aiming to create a treatment to solve muscle disorders, starting with Duchenne muscular dystrophy.

Our notion is that if we can restore muscle repair, well significantly reduce the severity and the progression of the disease, Rudnicki says.

He explains that Satellos discovered that the loss of function in those who have DMD is the result of problems with how muscle stem cells divide, wherein a process known as cell polarity is defective.

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Satellos main program, then, is focused on developing a drug that would correct muscle stem cell polarity and restore the bodys innate muscle repair and regeneration process by sending a signal to the muscle stem cell.

Gleeson says, In our bodies, we have biochemical pathways of different kinds and these are essentially like communication towers or satellites that enable mobile phone users to talk to one another. Similarly, signals are relayed through proteins interacting with each other, sometimes through biochemical stimulation, sometimes through physical interaction and sometimes through a combination of the two. Weve identified communication pathways that signal to muscle stem cells to act in certain ways, and were identified errors in these signals that inhibit proper muscle stem cell function.

Were intervening in those biochemical pathways to correct the signalling and restore stem cell function. It is space-age stuff and at the same time, its grounded in elegant science and a deep understanding of the mechanisms in play.

End of 2023 could see human safety trials

Satellos identified these pathways using MyoReGenXTM, a proprietary discovery platform grounded in decades of pioneering muscle stem cell knowledge established by Rudnickis research lab. That platform allows Satellos to conduct research by removing muscle fibre from the body, preserved intact, and studying it for biochemical cues.

So far, researchers have done preclinical work on proof of concept by studying genetically engineered mice and have found no serious side effects from drug candidates. While they continue on that path, Satellos aims to proceed with human safety trials by the end of 2023 and, once its through the safety phase, Gleeson says its possible the company could approach the U.S. Food and Drug Administration for accelerated approval in 2025.

While this is early science, we dont believe were that far away from being able to offer something helpful to patients, he says. To the patients, of course, it seems another lifetime of waiting and were very sensitive to that. But, from where we are in the context of typical drug development of 10 years and a billion dollars, were not that far away. And were working every day to find safe ways to go there sooner.

We strongly believe that we offer to the community of DMD patients and their families the chance for a disease-modifying treatment, something that could meaningfully alter an individuals life.

Broad palette of potential treatments

Frank and I had a meeting of minds very early about the aim to develop small molecules that mobilize stem cells to stimulate regeneration in tissue as a way forward to treat diseases, as a way forward for regenerative medicine, Rudnicki says. Weve incubated that idea through many, many conversations over the years.

Thus, DMD isnt the only target for Satellos leading-edge science. Considering the possibilities for its treatments to address muscle regeneration opens up a spectrum of conditions that could be addressed.

Not only do we see this as a relevant to multiple wasting disorders, he says, we think that other stem cells in other parts of the body can be targeted in the retina, in the brain, in the gut, the blood systems.

Gleeson notes that there are about 30 different types of dystrophies alone, in addition to sports injuries, surgical recovery and aging concerns.

The palette is very, very broad, he says.

A smart investment while doing good

Because that palette is broad, so is the potential good Satellos research can do, and thats a key part of the companys attraction to investors.

As well, in addition to executing a reverse takeover with iCo Therapeutics Inc. as one step in a strategy to raise capital and build value for shareholders, Satellos was able to do a concurrent financing of $7.25 million, which allowed the company to ramp up its team and amplify its drug discovery and development efforts.

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David Bautz, a senior biotechnology analyst with Zacks Small Cap Research, says Satellos is way undervalued compared to other companies doing DMD research.

The gene therapy approach [of some other companies] is not working, so Satellos is trying something thats completely different, says Bautz, who has a PhD in biochemistry. The theory behind it is very exciting, in my opinion. Theyre seeing exciting things in preclinical models, which is a good start.

From that perspective, while still risky, I think a lot of that risk is taken away by the fact Satellos valuation currently is so low, he says. And clearly the market values companies that are doing DMD treatment.

Indeed, Gleeson says the companys strong leadership team has established relationships with advocacy groups such as Parent Project Muscular Dystrophy, which made a US$1 million investment in its research.

Adds Rudnicki, These patients really have a significant demand for help. If they can use their hands or limbs to be more self-sufficient, even for a couple more years, thats a huge improvement in quality of life And we are very hopeful we can do more.

This is about changing the lives of these children who are unable to walk and are going to die at a young age.

And the potential for Satellos and its MyoReGenX platform doesnt stop with DMD because there are dozens of other degenerative conditions in muscle tissues as well as other parts of the body that could prove good targets for Satellos technology, among them complications associated with aging.

Says Rudnicki: Not only do we see this as relevant to multiple wasting disorders, we think that other stem cells in other parts of the body can be targeted in the retina, for example, possibly even in the brain.

For more information on Satellos Bioscience, visit its website.

Make sure to follow Satellos on social media for the latest updates:

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There can be no guarantee that the Company will obtain the required regulatory authorization/s to commence clinical trials in humans on a timely basis, or at all. The Company may not be able to translate its novel discoveries into viable therapeutic treatments suitable for clinical development.

This story was provided by Market One Media Group for commercial purposes.

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Satellos Bioscience pursues a revolutionary approach to treat muscle degeneration, give new hope to patients and parents - Financial Post

Amendment added to PA budget bill would make Pitt, other universities stop fetal tissue research – WPXI Pittsburgh

Amendment added to Pennsylvania budget bill would make Pitt, other universities stop fetal tissue research

An amendment just added to the state budget bill would make the University of Pittsburgh promise that they would stop fetal tissue research.

Some politicians and doctors are differing on the topic.

On the heels of Roe v. Wade being overturned, State Representative Jerry Knowles is calling for several universities to stop doing fetal cell research.

Pitt is one of those universities, plus Temple, Lincoln and Penn State.

Pitt is expected to receive $155 million in the next year from grant money, and is known for their fetal cell research and work.

Rep. Knowles told Channel 11, I respect doctors. I dont claim to be a doctor, or a scientist. I dont think you need to be a doctor or a scientist to determine what is unethical, what is evil, and what is barbaric.

Its something local infectious disease physician Dr. Amesh Adalja disagrees with.

We have already seen benefits from stem cell research, and research that derives from fetus cells. Even some of the covid vaccines were developed. This is a life saving technology.

Pitt spokesperson Chuck Finder sent us a statement:

The University of Pittsburgh devotes every dollar of the general support appropriation it receives from the state to help support a tuition discount for Pennsylvania students and families. Were optimistic the legislature will preserve this investment in our students.

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Amendment added to PA budget bill would make Pitt, other universities stop fetal tissue research - WPXI Pittsburgh

Cell Expansion Market Projection By Top Key Players, Regional Analysis Revenue Forecast Till 2030 Designer Women – Designer Women

New York(United States):- According to Report Ocean research report Global Cell Expansion Market: Analysis By Product Type (Instruments, Consumables, Disposables), By Cell Type (Human Cell and Animal Cell), By Application (Regenerative Medicine & Stem Cell Research and Cancer & Cell Based Research), By Region (North America, Europe, Asia Pacific, South America, and Middle East & Africa), (U.S, Canada, Germany, France, U.K., Japan, China, India): Opportunities and Forecast (2019 Edition): Forecast to 2024-, the cell expansion market is projected to display a robust growth represented by a CAGR of 17.33% during 2019 2024.

A comprehensive research report created through extensive primary research (inputs from industry experts, companies, stakeholders) and secondary research, the report aims to present the analysis of cell expansion market. The report analyses the Global Cell Expansion Market: Analysis By Product Type (Instruments, Consumables, Disposables), By Cell Type (Human Cell and Animal Cell), By Application (Regenerative Medicine & Stem Cell Research and Cancer & Cell Based Research), By Region (North America, Europe, Asia Pacific, South America, and Middle East & Africa), (U.S, Canada, Germany, France, U.K., Japan, China, India): Opportunities and Forecast (2019 Edition): Forecast to 2024, for the historical period of 2018-2019 and the forecast period of 2019-2024.

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Over the recent years, cell expansion market has been witnessing considerable growth directly on the back of increasing prevalence of chronic diseases such as cancer, diabetes, osteoarthritis, etc. Moreover, factors such as increasing investment in healthcare research, growing government initiatives, increasing adoption rate of new and technically instruments, rapidly evolving applicable segment market has been providing momentum to the overall market growth of cell expansion.

In addition, increasing demand for technically advanced products such as automated cell expansion systems and increasing number of cell GMP-certified cell expansion facilities are anticipated to fuel the market growth in forecasted period. However, recalls due to product failures have been hindering the market growth.

The report titled Global Cell Expansion Market: Analysis By Product Type (Instruments, Consumables, Disposables), By Cell Type (Human Cell and Animal Cell), By Application (Regenerative Medicine & Stem Cell Research and Cancer & Cell Based Research), By Region (North America, Europe, Asia Pacific, South America, and Middle East & Africa), (U.S, Canada, Germany, France, U.K., Japan, China, India): Opportunities and Forecast (2019 Edition): Forecast to 2024:-has covered and analysed the potential of cell expansion market and provides statistics and information on market size, shares and growth factors. The report intends to provide cutting-edge market intelligence and help decision makers take sound investment evaluation. Besides, the report also identifies and analyses the emerging trends along with major drivers, challenges and opportunities. Additionally, the report also highlights market entry strategies for various companies.

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Global Cell Expansion Market (Actual Period: 2014-2018, Forecast Period: 2019-2024)

Cell Expansion Market Size, Growth, Forecast Analysis By Product Type:Instruments, Consumables, Disposables. Analysis By Cell Type:Human Cells and Animal Cells. Analysis By Application Type:Regenerative Medicine & Stem Cell Research and Cancer & Cell Based Research. Regional Cell Expansion Market North America, Europe, Asia Pacific, South America, and Middle East & Africa (Actual Period: 2014-2018, Forecast Period: 2019-2024)

Cell Expansion Market Size, Growth, Forecast Analysis By Product Type: Instruments, Consumables, Disposables. Analysis By Cell Type:Human Cells and Animal Cells. Analysis By Application Type:Regenerative Medicine & Stem Cell Research and Cancer & Cell Based Research. Country Cell Expansion Market U.S., Canada, Germany, U.K, France, China, Japan, India (Actual Period: 2014-2018, Forecast Period: 2019-2024)

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Cell Expansion Market Size, Growth, ForecastAnalysis By Product Type: Instruments, Consumables, Disposables. Analysis By Cell Type:Human Cells and Animal Cells. Analysis By Application Type:Regenerative Medicine & Stem Cell Research and Cancer & Cell Based Research.

Other Report HighlightsMarket Dynamics Drivers and Restraints. Market Trends. Porter Five Forces Analysis. SWOT Analysis.

Company Analysis Merck Millipore, Eppendorf, ThermoFisher Scientific, Becton Dickinson, Danaher Corporation, Corning Inc., Terumo Medical Corporation, CellGenix Technologie Transfer GmbH, Synthecon Inc., Stem Cell Technologies Inc.

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Cell Expansion Market Projection By Top Key Players, Regional Analysis Revenue Forecast Till 2030 Designer Women - Designer Women

Hematopoietic Stem Cell Transplantation Market Research by Size, Share, Trends, Business Opportunities and Top Manufacture and Forecast by 2029 …

Data Bridge Market Research analyses that the Hematopoietic stem cell transplantation market was valued at USD 2,337.43 million in 2021 and is expected to reach USD 5,664.54 million by 2029, registering a CAGR of 11.70% during the forecast period of 2022 to 2029. The market report curated by the Data Bridge Market Research team includes in-depth expert analysis, patient epidemiology, pipeline analysis, pricing analysis, and regulatory framework.

While designing a reliable Global Hematopoietic Stem Cell Transplantation Market market report, absolute industry insight, talent solutions, practical solutions and use of technology are merged together very well to advance user experience. Companies can accomplish an effectual business growth if they adopt market research report like this market report which seems to be very vital in this rapidly changing marketplace. The report brings to notice many aspects regarding HEALTHCARE industry and market. These are mainly covered with market definition, market segmentation, competitive analysis and research methodology as major topics of the winningGlobal Hematopoietic Stem Cell Transplantation Marketreport. It explains market drivers and market restraints in detail which aids businesses in guessing about reducing or increasing the production of specific product.

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The significantGlobal Hematopoietic Stem Cell Transplantation Marketmarket research report looks at the key aspects of the market including its market improvement, development, position and others. It highlights the global key manufacturers and analyzes the market competition landscape. The industry inquiries in this report provide an examination and data as specified by classes. What is more, this report conducts analysis on the sales (consumption) of market, focuses on the top players to assess their sales, price, revenue and market share with volume and value for each region.Global Hematopoietic Stem Cell Transplantation Marketreport also comprises of a bottomless knowledge on market definition, market drivers and market restraints, classifications, applications, and engagements.

TopCompaniesin Global Hematopoietic Stem Cell Transplantation Market Report:

Otsuka America Pharmaceutical, Inc. (US), Akari Therapeutics, Plc (US), Merck KGaA (Germany), Takeda Pharmaceutical Company Limited (Japan), Lonza (Switzerland), GlaxoSmithKline plc (UK), Novartis AG (Switzerland), Merck & Co., Inc. (US), Pfizer Inc. (US), Sanofi (France), FUJIFILM Holdings Corporation (Japan), bluebird bio, Inc. (US), Pluristem Therapeutics Inc. (Israel), Regen Biopharma Inc. (US), Kiadis Pharma (Netherlands), Taiga Biotechnologies, Inc. (US), CellGenix GmbH (Germany), Escape Therapeutics, Inc. (US), Marker Therapeutics, Inc. (US), Talaris Therapeutics (US)

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Regional Analysis

U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

The persuasive Global Hematopoietic Stem Cell Transplantation Market marketing report provides top to bottom examination of the market as far as income and developing business sector is concerned. This business report displays systemic company profiles which illustrate how the moves of several key players and brands are driving the market. It also covers predictions regarding reasonable arrangement of uncertainties and latest techniques. The report also performs study on the market drivers and market restraints which are derived from SWOT analysis. The large scaleGlobal Hematopoietic Stem Cell Transplantation Marketmarket report considers wide scope that takes into account market scenarios, comparative pricing between major players, expenditure and profit of the specified market regions.

Under the topic of market segmentation, research and analysis is carried out based on application, vertical, deployment model, end user, and geography. Besides, competitive analysis assists to get ideas about the strategies of key players in the market via theGlobal Hematopoietic Stem Cell Transplantation Marketmarket document. Few of these strategies can be listed as; new product launches, expansions, agreements, partnerships, joint ventures, acquisitions, and others that help to broaden their footprints in the HEALTHCARE industry. The market share of key competitors on worldwide level is studied where main regions such as Europe, North America, Asia Pacific and South America are tackled in the universalGlobal Hematopoietic Stem Cell Transplantation Marketmarket survey report.

Highlights of TOC: Global Global Hematopoietic Stem Cell Transplantation Market Market

1 Global Global Hematopoietic Stem Cell Transplantation Market Market Overview

2 Global Global Hematopoietic Stem Cell Transplantation Market Market Competitions by Manufacturers

3 Global Global Hematopoietic Stem Cell Transplantation Market Capacity, Production, Revenue (Value) by Region (2022-2029

4 Global Global Hematopoietic Stem Cell Transplantation Market Supply (Production), Consumption, Export, Import by Region (2022-2029)

5 Global Global Hematopoietic Stem Cell Transplantation Market Production, Revenue (Value), Price Trend by Type

6 Global Global Hematopoietic Stem Cell Transplantation Market Market Analysis by Application

7 Global Global Hematopoietic Stem Cell Transplantation Market Manufacturers Profiles/Analysis

8 Global Hematopoietic Stem Cell Transplantation Market Manufacturing Cost Analysis

9 Industrial Chain, Sourcing Strategy and Downstream Buyers

10 Marketing Strategy Analysis, Distributors/Traders

11 Market Effect Factors Analysis

12 Global Global Hematopoietic Stem Cell Transplantation Market Market Forecast (2022-2029)

13 Research Findings and Conclusion

14 Appendix

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Goals and objectives of the Global Hematopoietic Stem Cell Transplantation Market Market Study

This Global Hematopoietic Stem Cell Transplantation Market Market Research/analysis Report Focus on following important aspects:

Key questions answered in the report:

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Hematopoietic Stem Cell Transplantation Market Research by Size, Share, Trends, Business Opportunities and Top Manufacture and Forecast by 2029 ...

iTolerance, Inc. Awarded Industry Discovery and Development Partnership with JDRF for Advanced Pre-Clinical Development of iTOL-100 and iTOL-101 for…

Company advancing development of lead program, iTOL-101, as a potential breakthrough in curing Type 1 Diabetes with the potential to eliminate the need for chronic life-long immunosuppression

The up to $850,000 award issued to iTolerance was given in furtherance of JDRF's charitable mission to cure and mitigate the effects of Type 1 Diabetes

MIAMI, FL / ACCESSWIRE / June 28, 2022 / iTolerance, Inc. ("iTolerance" or the "Company"), an early-stage regenerative medicine company developing technology to enable tissue, organoid or cell therapy without the need for life-long immunosuppression, today announced it has been awarded an Industry Discovery and Development Partnership ("IDDP") of up to $850,000 from JDRF, a nonprofit organization that funds Type 1 Diabetes (T1D) research, provides a broad array of community and activist services to the T1D population and actively advocates for regulation favorable to medical research and approval of new and improved treatment modalities.

iTolerance, Inc., Tuesday, June 28, 2022, Press release picture

Anthony Japour, MD, Chief Executive Officer of iTolerance, commented, "We are incredibly pleased to expand and deepen our partnership with the JDRF. We are grateful for their continued support and dedication to the Type 1 Diabetes community. This funding provides us with the additional capital to support the translation of iTOL-100 production, iTolerance's proprietary biotechnology-derived fusion protein immunomodulator platform, from the academic research laboratories to commercial manufacturing. In addition, the partnership will support Good Laboratory Practice efficacy, safety, toxicology, and pharmacokinetic studies. This will put us a step closer toward a first in human Phase 1/2a clinical trial."

Dr. Japour continued, "The support that the JDRF has provided to our team thus far has been significantly valuable in enabling us to complete our pre-clinical non-human primate study which demonstrated long-term success of allogeneic islet implantation without chronic immunosuppression for the treatment of diabetes. The results from that landmark study were recently published[1] in the peer-reviewed journal, Science Advances. We believe the extension of their support with this IDDP is truly a natural next step as we collectively advance towards a potential breakthrough cure for T1D without the need for chronic immunosuppression."

Story continues

The JDRF award to iTolerance is in support of advancing the Company's platform technology, iTOL-100, which leverages the naturally occurring protein, Fas Ligand (FasL) which is present in all mammals and functions as a natural way for the body to establish local immune tolerance. In pre-clinical studies conducted to date, iTOL-100 has been shown to establish durable, localized immune tolerance, allowing the implanted tissue, organoid or cell therapy to function as a replacement for damaged native cells. Additionally, the award supports the advancement of pre-clinical studies evaluating iTolerance's lead program, iTOL-101, to support a first-in-human clinical study in Type 1 Diabetes.

"We enthusiastically support the iTolerance team's effort toward translating to the clinic the work of our JDRF-funded researchers. The recently published study demonstrates long-term glycemic control in a non-human primate model of diabetes by combining allogenic islets with the SA-FasL microgel. This work has the promise to provide a cell replacement therapy that cures T1D without the need for chronic immunosuppression. The advancement of pre-clinical development builds on the ongoing support from JDRF and we look forward to this next stage of development," added Esther Latres, Ph.D., JDRF Vice President of Research.

About JDRF

JDRF's mission is to accelerate life-changing breakthroughs to cure, prevent and treat T1D and its complications. To accomplish this, JDRF has invested more than $2.5 billion in research funding since our inception. We are an organization built on a grassroots model of people connecting in their local communities, collaborating regionally for efficiency and broader fundraising impact, and uniting on a national stage to pool resources, passion, and energy. We collaborate with academic institutions, policymakers, and corporate and industry partners to develop and deliver a pipeline of innovative therapies to people living with T1D. Our staff and volunteers throughout the United States and our five international affiliates are dedicated to advocacy, community engagement and our vision of a world without T1D. For more information, please visit jdrf.org or follow us on Twitter (@JDRF), Facebook (@myjdrf), and Instagram (@jdrfhq).

About iTOL-100

The Company's iTOL-100 platform technology is a biotechnology-derived Strepavidin-FasL fusion protein, a synthetic form of the naturally occurring protein FasL, mixed with a biotin-PEG microgel (SA-FasL microgel) that potentially allows convenient and effective co-administration with implanted cells or organoids to induce local immune tolerance without the need for life-long immunosuppression. In pre-clinical studies, iTOL-100 has been shown to establish durable, localized immune tolerance, allowing the implanted tissue, organoid or cell therapy to function as a replacement for damaged native cells. iTOL-100 has broad applicability and can be applied to both allogenic and stem cell-derived organoids across a number of diseases.

About iTolerance, Inc.

iTolerance is an early-stage privately held regenerative medicine company developing technology to enable tissue, organoid or cell therapy without the need for life-long immunosuppression. Leveraging its proprietary biotechnology-derived Strepavidin-FasL fusion protein/biotin-PEG microgel (SA-FasL microgel) platform technology, iTOL-100, iTolerance is advancing a pipeline of programs using both allogenic pancreatic islets and stem cells that have the potential to cure diseases. The Company's lead program, iTOL-101 is being developed for Type 1 Diabetes and in a pre-clinical non-human primate study, pancreatic islet cells co-implanted with iTOL-101 exhibited long-term function with control of blood glucose levels and restoration of insulin secretion without the use of chronic immune suppression. The Company's second lead candidate, iTOL-102, is leveraging significant advancements in stem cells to derive pancreatic islets which allows an inexhaustible supply of insulin-producing cells. Utilizing iTOL-100 to induce local immune tolerance, iTOL-102 has the potential to be a cure for Type 1 Diabetes without the need for life-long immunosuppression. Additionally, the Company is developing iTOL-201 for liver failure and iTOL-301 as a potential regenerative protein and cell therapy that leverages stem cell sources to produce proteins or hormones in the body in conditions of high unmet need without the need for life-long immunosuppression. For more information, please visit itolerance.com.

Forward-Looking Statements

This press release contains "forward-looking statements" within the meaning of the "safe-harbor" provisions of the Private Securities Litigation Reform Act of 1995. When used herein, words such as "anticipate", "being", "will", "plan", "may", "continue", and similar expressions are intended to identify forward-looking statements. In addition, any statements or information that refer to expectations, beliefs, plans, projections, objectives, performance or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking.

All forward-looking statements are based upon the Company's current expectations and various assumptions. The Company believes there is a reasonable basis for its expectations and beliefs, but they are inherently uncertain. The Company may not realize its expectations, and its beliefs may not prove correct. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various important factors, including, without limitation, anticipated levels of revenues, future national or regional economic and competitive conditions, and difficulties in developing the Company's platform technology. Consequently, forward-looking statements should be regarded solely as the Company's current plans, estimates and beliefs. Investors should not place undue reliance on forward-looking statements. The Company cannot guarantee future results, events, levels of activity, performance or achievements. The Company does not undertake and specifically declines any obligation to update, republish, or revise any forward-looking statements to reflect new information, future events or circumstances or to reflect the occurrences of unanticipated events, except as may be required by law.

[1] https://www.science.org/doi/abs/10.1126/sciadv.abm9881

Investor Contact:

Jenene Thomas Chief Executive Officer JTC Team, LLC T: 833.475.8247 iTolerance@jtcir.com

SOURCE: iTolerance, Inc.

View source version on accesswire.com: https://www.accesswire.com/706772/iTolerance-Inc-Awarded-Industry-Discovery-and-Development-Partnership-with-JDRF-for-Advanced-Pre-Clinical-Development-of-iTOL-100-and-iTOL-101-for-the-Treatment-of-Type-1-Diabetes

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iTolerance, Inc. Awarded Industry Discovery and Development Partnership with JDRF for Advanced Pre-Clinical Development of iTOL-100 and iTOL-101 for...

Beam Therapeutics to Present First Research Highlighting Approach to Develop Non-Genotoxic Conditioning Regimens for Patients with Sickle Cell Disease…

CAMBRIDGE, Mass., June 27, 2022 (GLOBE NEWSWIRE) -- Beam Therapeutics Inc. (Nasdaq: BEAM), a biotechnology company developing precision genetic medicines through base editing, today announced that new research highlighting the companys internal efforts to develop improved transplant conditioning regimens for patients with sickle cell disease (SCD) undergoing hematopoietic stem cell transplantation (HSCT) will be presented today, June 27, 2022, at 4:00 p.m. CEST at the Federation of American Societies for Experimental Biology (FASEB) Genome Engineering Conference by Nicole Gaudelli, Ph.D., director, head of gene editing at Beam. The conference is being held from June 26-30, 2022, in Lisbon, Portugal.

Beam is advancing two ex vivo base editing programs for SCD: BEAM-101, which incorporates base edits that are designed to mimic single nucleotide polymorphisms seen in individuals with hereditary persistence of fetal hemoglobin, and BEAM-102, which directly edits the causative HbS point mutation to recreate a naturally occurring normal human hemoglobin variant, HbG-Makassar. In the second half of 2022, Beam plans to initiate patient enrollment in its clinical trial with BEAM-101 and to submit an investigational new drug application for BEAM-102.

Beam has laid out a long-term strategy to support broad accessibility of base editing treatments for patients with SCD and other hematologic diseases. A key component of this strategy is focused on improving the safety of conditioning regimens, a required pretreatment for patients receiving ex vivo gene editing treatment via autologous transplant. Todays conditioning regimens rely on nonspecific chemotherapy or radiation, which are associated with significant toxicities, including genotoxicity, primary or secondary malignancy, and organ toxicities including infertility. With a goal of overcoming this, Beam has leveraged its base editing capabilities to develop a potentially non-genotoxic approach that combines antibody-based conditioning with multiplex gene edited hematopoietic stem cells (HSCs) called ESCAPE, or Engineered Stem Cell Antibody Paired Evasion.

As we execute on our long-term strategy to develop base editing treatments for SCD, we are excited to share new findings around our pre-clinical research to identify improved conditioning regimens for patients ahead of autologous transplant, said Giuseppe Ciaramella, Ph.D., president and chief scientific officer of Beam. The findings being presented today showcase the first data from our efforts to advance an improved non-genotoxic conditioning approach, coupling a monoclonal antibody with multiplex base edited HSCs that both ESCAPE antibody binding and contain disease-corrective edits to potentially ameliorate the clinical manifestations of SCD. By exploiting the unique multiplex capabilities of base editing in these next-generation conditioning and cell-engineering approaches, we aim to develop a curative treatment for patients with SCD that avoids the safety and fertility concerns associated with current conditioning regimens. These findings are a major step forward in our efforts to enable potentially highly efficacious conditioning options for patients with SCD and could significantly increase the probability of success of non-genotoxic conditioning, which is a key priority in the field. We look forward to rapidly advancing this work as part of our long-term strategy to bring safer and more effective options forward for patients with SCD.

New antibody-based conditioning agents have shown promise in targeting CD117, an optimal conditioning target for eliminating HSCs, but such antibodies generally cannot discriminate between host (disease-carrying) and transplanted (disease-corrected) cells, and therefore are designed with short half-life or dosed at low concentrations well before transplant. To potentially solve for this and other safety concerns associated with current conditioning regimens, Beam scientists developed ESCAPE, whereby an edit-antibody pair targeting CD117 was designed to enable edited HSCs to function normally but escape the binding of the conditioning antibody. This strategy is intended to allow the conditioning antibody to continue clearing older unedited host cells while selectively allowing new edited cells to proliferate in the body during engraftment.

The findings show that in vitro the ESCAPE antibodies bound to wild-type CD117, blocked binding of its ligand and led to depletion of unedited cells, while enriching for edited cells which were generally not bound by the antibody. High levels of editing efficiency were demonstrated with both a single CD117 edit and simultaneous CD117 and BEAM-101 edits (~85% multiplex editing). Beam has also developed a CD117 editing strategy with greater than 75% editing efficiency that is also compatible with an edit to correct the sickle mutation and generate HbG-Makassar, Beams strategy with its BEAM-102 program. Relative to a control, ESCAPE reduced cell viability of unedited cells while maintaining CD117 edited cellsin vitro,suggesting utility as a conditioning agent with a selective advantage to edited HSCs post-transplant.

About Beam Therapeutics Beam Therapeutics (Nasdaq: BEAM) is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beams suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.

Cautionary Note Regarding Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Investors are cautioned not to place undue reliance on these forward-looking statements, including, but not limited to, statements related to: our presentation at FASEB; our plans, and anticipated timing, to initiate patient enrollment in our BEAM-101 clinical trial and to submit an investigational new drug application for Beam-102; the therapeutic applications and potential of our technology, including with respect to improved conditioning regimens and sickle cell disease; and our ability to develop life-long, curative, precision genetic medicines for patients through base editing. Each forward-looking statement is subject to important risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statement, including, without limitation, risks and uncertainties related to: our ability to develop, obtain regulatory approval for, and commercialize our product candidates, which may take longer or cost more than planned; our ability to raise additional funding, which may not be available; our ability to obtain, maintain and enforce patent and other intellectual property protection for our product candidates; the potential impact of the COVID-19 pandemic; that preclinical testing of our product candidates and preliminary or interim data from preclinical studies and clinical trials may not be predictive of the results or success of ongoing or later clinical trials; that enrollment of our clinical trials may take longer than expected; that our product candidates may experience manufacturing or supply interruptions or failures; risks related to competitive products; and the other risks and uncertainties identified under the headings Risk Factors Summary and Risk Factors in our Annual Report on Form 10-K for the year ended December 31, 2021, under the heading Risk Factors in our Quarterly Report on Form 10-Q for the quarter ended March 31, 2022, and in any subsequent filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date of this press release. Factors or events that could cause our actual results to differ may emerge from time to time, and it is not possible for us to predict all of them. We undertake no obligation to update any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by applicable law.

Contacts:

Investors: Chelcie Lister THRUST Strategic Communications chelcie@thrustsc.com

Media: Dan Budwick 1AB dan@1abmedia.com

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Beam Therapeutics to Present First Research Highlighting Approach to Develop Non-Genotoxic Conditioning Regimens for Patients with Sickle Cell Disease...