Cell Separation Technology Market: Industry Development Scenario and Forecast to 2027 – Eurowire

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The report further sheds light on the various strategic business initiatives undertaken by the key market contenders to fortify their foothold in this business sector. These strategies majorly include mergers & acquisitions, partnerships & collaborations, joint ventures, government and corporate deals, brand promotions, new product launches, and numerous others. In the later part of the report, the major components of the Cell Separation Technology industry, such as product type, application gamut, end-use industries, and the solutions and services offered by the leading manufacturers, have been analyzed. Numerical data and subjective information pertaining to each market segment have been featured in the report for better understanding.

Therefore, the latest research document includes competitive analysis, key market players, crucial industry-related facts & figures, sales revenue, product prices, gross margins, market shares, business strategies, dominant regions, and key developments.

Cell Separation Technology Market, By Type

Density Gradient Centrifugation Immunodensity Cell Separation Microfluidic Cell Separation Immunomagnetic Cell Separation Fluorescence-activated Cell Sorting (FACS) Others

Cell Separation Technology Market, By Application

Stem Cell Research Immunology Neuroscience Cancer Research Others

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The report encompasses the significant effects of the coronavirus pandemic on the Cell Separation Technology market and its key segments. The report offers a vivid picture of the current market scenario, closely investigating the impact of the pandemic on this specific business sphere, its leading players, supply chains, distribution channels, and its global scenario. The pandemic has affected the global industry extensively, subsequently disrupting the Cell Separation Technology market mechanism. Furthermore, the research study examines the Cell Separation Technology market and the recent disruptive changes in the business setting that followed the outbreak. Also, the future effects of the pandemic on the market have been assessed in the report.

Key Geographies Encompassed in the Report:

North America (U.S., Canada) Europe (U.K., Germany, Italy, France, Rest of EU) Asia Pacific (India, Japan, China, Australia, Rest of APAC) Latin America (Brazil, Argentina, Rest of Latin America) Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of MEA)

Market Taxonomy:

Chapter 1: Methodology & Scope

Definition and forecast parameters Methodology and forecast parameters Data Sources

Chapter 2: Executive Summary

Business trends Regional trends Product trends

Chapter 3: Industry Insights

Industry segmentation Industry landscape Vendor matrix Technological and innovation landscape

Chapter 4: Regional Landscape

Chapter 5: Competitive Outlook

Company Profile Business Overview Financial Data Product Landscape Strategic Outlook

To read more about the report, visit @ https://www.verifiedmarketresearch.com/product/cell-separation-technology-market/

Advantages of the Cell Separation Technology Market Report:

The report offers a clear description of the global Cell Separation Technology market, containing the current market growth inclinations and future estimations to help businesses identify the potential investment areas.

The report covers the major market growth drivers, and constraints, alongside an extensive COVID-19 impact analysis.

The all-inclusive market feasibility reveals the profit-making trends to obtain a powerful foothold in the Cell Separation Technology industry.

The SWOT analysis and Porters Five Forces Analysis explicate the effectiveness of the customers and providers from a global perspective.

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Cell Separation Technology Market: Industry Development Scenario and Forecast to 2027 - Eurowire

Global Stem Cell Assay Market Expected to Reach Highest CAGR By 2026: GE Healthcare, Promega Corporation, Thermo Fisher Scientific, Merck KGaA,…

Regional Development: Detailed Analysis

The latest report presentation on Global Stem Cell Assay market portrays a detailed analytical review of the market spectrum across both historical and current timelines, complete with thorough details on prominent events, catastrophic implications as well as segment advancement and technological milestones that tend to have a lingering influence on unperturbed growth prognosis in global Stem Cell Assay market.

In-depth research delving into past developments and growth trends, besides significant analysis of current events and developments, suggest that holistic growth in global Stem Cell Assay market is touted to reach over xx million USD by the end of 2025, with CAGR amplification of xx% through the forecast span, 2019-25.

The study encompasses profiles of major companies operating in the Stem Cell Assay Market. Key players profiled in the report includes:

We Have Recent Updates of Stem Cell Assay Market in Sample [emailprotected] https://www.orbismarketreports.com/sample-request/142074?utm_source=PoojaM

The report spans across determining crucial developments for various lucrative growth hotspots such spread over 50 countries during the growth span, 2020-25. A clear analytical review of vital details such as supply and logistics outlook, segment development and investments as well as manufacturer and vendor activities favoring high end returns in a highly competitive landscape.

The report critically assesses the frontline players and their company positioning amidst staggering competition and lingering eventful milestones. Each of the profiled players mentioned in the report has been thoroughly evaluated to include a detailed overview of market segments inclusive of type and applications. The report also includes details in region wise advances and consumer behavior and activities across countries and regions.

Segment Stratification by Product: The report includes details on production, consumption, import and export developments along with sales volume and value-based projections are meticulously ingrained in the report. Developments in CAGR projections are also tagged in the report.

Segment Stratification by Application: The report also ropes in versatile details on end-use applicability user preferences and vendor participation that collectively steer tremendous growth potential in global Stem Cell Assay market.

Additionally, this intensive research report has also been deployed to adequately answer the queries of inquisitive report readers and market participants pertaining to COVID-19 pandemic analysis and corresponding recovery.

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One of the most relevant research inputs in global Stem Cell Assay market is COVID-19 impact analysis. The pre and post analytical developments in global Stem Cell Assay market have also been thoroughly included in the report to ensure reader understanding and subsequent investment discretion. Assessment of the market dynamics across both the timelines is integral to ensure accurate forecast analysis and growth projections.

Geographical Segmentation and Competition Analysis This section of the report proceeds further with divulging high end details on regional overview, highlighting chief growth hotspots, vendor participation as well as consumer expectations that collectively determine futuristic growth prognosis in global Stem Cell Assay market.

The following is a complete run-down of geography-based analysis of Stem Cell Assay market:

North America (U.S., Canada, Mexico) Europe (U.K., France, Germany, Spain, Italy, Central & Eastern Europe, CIS) Asia Pacific (China, Japan, South Korea, ASEAN, India, Rest of Asia Pacific) Latin America (Brazil, Rest of L.A.) Middle East and Africa (Turkey, GCC, Rest of Middle East)

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Details such as trend analysis, opportunity mapping and barrier analysis have all been thoroughly evaluated in the report to encourage high end growth and long-term sustainability. These report inputs are in complete alignment with growth objectives of the new entrants as well as market veterans holding legacy growth stance in global Stem Cell Assay market.

Why to Invest in the Report team of expert research professionals are committed to offer high end industry-specific critical reports inclusive of high accuracy insights for future-ready business discretion.

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Global Stem Cell Assay Market Expected to Reach Highest CAGR By 2026: GE Healthcare, Promega Corporation, Thermo Fisher Scientific, Merck KGaA,...

European Investment Bank provides Minoryx with up to 25 million to support development of breakthrough therapies in orphan neurodegenerative diseases…

EUROPEAN INVESTMENT BANK PROVIDES MINORYX WITH UP TO 25 MILLION TO SUPPORT DEVELOPMENT OF BREAKTHROUGH THERAPIES IN ORPHAN NEURODEGENERATIVE DISEASES

Matar, Barcelona, Spain and Gosselies, Belgium, October 30, 2020 Minoryx Therapeutics, a Phase 3 clinical stage biotech company focused on the development of differentiating treatment options in orphan central nervous system (CNS) disorders, today announces that the European Investment Bank (EIB) has approved a 25 million financing.

The EU bank will grant long-term financing to Minoryx to drive the companys research and development activities in orphan genetic diseases for which there are currently no approved drugs available. The EIB investments will specifically support the development of Minoryxs leriglitazone, a differentiated, disease-modifying PPAR-y agonist currently being evaluated in three late-stage clinical trials:

Estimates indicate that the investment in this research, development and innovation (RDI) project will help create over 50 jobs during the implementation phase.

EIB Vice-PresidentRicardo Mourinho Flix, who is responsible for the Banks operations inSpain, said: We are very happy to sign an agreement that reaffirms the EIBs commitment to fostering innovation in the healthcare sector by driving the development of new treatments that will have a positive impact on the quality of life of people affected by rare diseases of the central nervous system. Our support for the research programme of Minoryx, a Spanish biotech company, will also help to improve the competitiveness of the European pharmaceutical industry and create highly skilled jobs.

European Commissioner for the Economy, Paolo Gentiloni, said:This EU support will help Minoryx to develop breakthrough therapies for genetic diseases and treatments for diseases of the central nervous system. The coronavirus pandemic has shown how important it is to continue to push scientific boundaries and deliver medication for rare diseases. The European Commission will continue to support companies efforts in this sense at every opportunity.

The EIB brings Minoryx valuable financial resources, alongside our strong and supportive shareholders base, which, we believe, is a clear endorsement of the potential of leriglitazone to improve the lives of patients living with debilitating neurodegenerative disorders,saidDidier Le Normand, Group CFO and General Manager, Belgium.

The current clinical studies with leriglitazone continue to advance as planned and we remain on track to report topline data from the pivotal ADVANCE study before the end of the year,added Dr Marc Martinell, Co-Founder and CEO of Minoryx.

The EIB will provide funds for this RDI project by way of a venture debt operation under theEuropean Fund for Strategic Investments (EFSI), a financing instrument used by the EU bank to assist leading companies in innovative research sectors. Since it was launched by the EIB under the Juncker Plan in 2016, this initiative has granted over 2billion in financing for projects in sectors such as robotics, artificial intelligence and biomedicine. EIB venture debt financing targets European companies with up to 3,000 employees in the fields of biotechnology and health sciences, software and ICT, engineering and automation, and renewable energy and clean technology.

About the EIB

TheEIB Groupcomprises the European Investment Bank (EIB) andEuropean Investment Fund(EIF). The EIB is the European Unions long-term lending institution owned by its Member States. In 2019, the EIB provided 63.3billion for projects across the world, including investments for healthcare, SMEs and climate action. Spain was among the largest beneficiaries of this financing, receiving almost 9billion.

About EIB venture debt and Investment Plan for Europe

The EIBs venture debt product is a financing instrument that supports startup and fast-growing innovative companies in cutting-edge technology sectors. It combines the advantages of a long-term loan with a remuneration model based on the companys performance. Venture debt transactions help strengthen the borrowers economic capital without diluting the shares of existing investors. The product, developed four years ago in response to market needs, is backed by the European Fund for Strategic Investments (EFSI), the financial pillar of the Investment Plan for Europe. The European Fund for Strategic Investments (EFSI) is the main pillar of theInvestment Plan for Europe. It provides first-loss guarantees enabling the EIB to invest in more and often riskier projects. The projects and agreements approved for financing under the EFSI have mobilised 535.4 billion in investment so far, a quarter of which is supporting research, development and innovation projects.

About Minoryx

Minoryx is a clinical stage biotech company focusing on the development of novel therapies for orphan CNS diseases with high unmet medical needs. The companys lead program, leriglitazone (MIN-102), a novel, selective PPARy agonist, is currently being evaluated in X-ALD and Friedreichs Ataxia. The company is backed by a syndicate of experienced investors, which includes Caixa Capital Risc, Roche Venture Fund, Ysios Capital, Kurma Partners, Fund+, Chiesi Ventures, S.R.I.W, Idinvest, SFPI-FPIM, HealthEquity and Sambrinvest, and has support from a network of other organizations. Minoryx was founded in 2011, has operations in Spain and Belgium and has so far raised more than 60M.

http://www.minoryx.com

About leriglitazone

Leriglitazone (MIN-102) is a novel bioavailable and selective PPAR-? agonist with a potential best-in-class profile indicated for CNS diseases. It has demonstrated sufficient brain penetration and a favorable safety profile. It showed robust preclinical proof-of-concept in animal models of multiple diseases by modulating pathways leading to mitochondrial dysfunction, oxidative stress, neuroinflammation, demyelination and axonal degeneration. Leriglitazone has successfully completed a Phase 1 clinical trial showing good safety, tolerability and CNS engagement of PPAR-y receptors at levels equivalent to those required for efficacy in preclinical models. Leriglitazone has the potential to treat several CNS disorders, including orphan diseases, and is currently being evaluated in a registration enabling Phase 2/3 study in AMN, a registration enabling Phase 2 in cALD and in a Phase 2 in Friedreichs Ataxia.

About X-ALD

X-ALD (X-linked adrenoleukodystrophy) is an orphan neurodegenerative disease. AMN and cALD are the two most common phenotypes of X-ALD, which account for 45% and 35% respectively. The global incidence of X-ALD is approximately 6.2/100,000 live births.

The age of onset of cALD patients is typically 4-8 years old. Untreated patients progress quickly, as severe neurological function impairment appears 6-24 months after disease onset, leading to early death in 2-4 years.

AMN is characterized by progressive spastic paraparesis, sensory dysfunction and incontinence. This form progresses chronically with onset of symptoms typically in adulthood and poor prognosis.

There is currently no therapeutic treatment available for X-ALD. Several observational studies have demonstrated that hematopoietic stem cell transplantation (HSCT) may improve the five-year overall survival for cALD patients. However, there is no evidence that HSCT improves clinical outcomes of patients with AMN.

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European Investment Bank provides Minoryx with up to 25 million to support development of breakthrough therapies in orphan neurodegenerative diseases...

Global Stem Cells Market 2020 Industry Demand, Share, Global Trend, Top Key Players Update, Business Statistics And Research Methodology By Forecast…

The latest market report published by Reports and Data, titled Global Stem Cells Market, presents an accurate analysis of the estimated market size, share, revenue, and sales & distribution networks of the global Stem Cells market over the forecast period. The report offers an exhaustive overview of the market, along with a precise summary of the markets leading regions. Our team of analysts has studied the existing competitive landscape of the market inside out, focusing on the leading companies and their business expansion strategies. The report ends with conclusive data offering useful insights into the market growth on both regional and global levels.

The report covers extensive analysis of the key market players in the market, along with their business overview, expansion plans, and strategies. The key players studied in the report include:

Thermo Fisher Scientific, Agilent Technologies, Illumina, Inc., Qiagen, Oxford Nanopore Technologies, Eurofins Scientific, F. Hoffmann-La Roche, Danaher Corporation, Bio-Rad Laboratories, and GE Healthcare

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The report draws the focus of the reader on the grave impact of the ongoing COVID-19 pandemic on the Stem Cells industry and its vital segments and sub-segments. It elaborates on the adverse effects of the pandemic on the global economic scenario, as well as this particular business sphere. The report takes into account the key influencing factors influencing market performance in the present COVID-19 times. The market has been substantially affected by the pandemic, and significant changes have been observed in the market dynamics and demand trends. The report examines the major financial difficulties brought about by the pandemic and offers a future COVID-19 impact assessment.

The market intelligence study takes the reader through the key parameters of the Stem Cells market, including the strengths and weaknesses of the leading players, using analytical tools like the SWOT analysis and Porters Five Forces analysis. The report includes broad market segmentation based on the different product types, a wide application spectrum, the key regions, and the existing competition among players.

Product Outlook (Revenue, USD Billion; 2017-2027)

Technology Outlook (Revenue, USD Billion; 2017-2027)

Therapy Outlook (Revenue, USD Billion; 2017-2027)

Application Outlook (Revenue, USD Billion; 2017-2027)

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The investigative study further assesses the market on the basis of market reach and consumer base in the key geographical segments. Alongside reviewing the sales network, distribution channels, pricing analysis, profit margins, cost and demand volatility, import/export dynamics, gross revenue, and various other aspects of the market, the report studies several factors affecting market growth over the forecast period, such as drivers, restraints, limitations, growth prospects, and numerous macro- and micro-economic indicators.

Key Geographies Encompassed in the Report:

Key questions addressed in the report:

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Our in-house experts assist our clients with advice based on their proficiency in the market that helps them in creating a compendious database for the clients. Our team offers expert insights to clients to guide them through their business ventures. We put in rigorous efforts to keep our clientele satisfied and focus on fulfilling their demands to make sure that the end-product is what they desire. We excel in diverse fields of the market and with our services extending to competitive analysis, research and development analysis, and demand estimation among others, we can help you invest your funds in the most beneficial areas for research and development. You can rely on us to provide every significant detail you might need in your efforts to make your business flourish.

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Global Stem Cells Market 2020 Industry Demand, Share, Global Trend, Top Key Players Update, Business Statistics And Research Methodology By Forecast...

Contract Manufacturing Services Market for stem cells is expected to be worth over USD 2.5 billion by 2030, claims Roots Analysis – KYT24

Driven by a robust and growing pipeline of stem cell therapies, the demand for development and manufacturing services for such advanced product candidates is anticipated to increase beyond the capabilities of innovator companies alone

Roots Analysis has announced the addition of the Stem Cell Contract Manufacturing Market, 2019-2030 report to its list of offerings.

Owing to a highly regulated production environment and the need for state-of-the-art technologies and equipment, it is difficult for innovators to establish in-house expertise for the large-scale manufacturing of stem cell therapies. As a result, stem cell therapy developers are increasingly relying on contract manufacturing organizations (CMOs) for their product development and manufacturing needs.

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Over 80 CMOs presently claim to provide manufacturing services for stem cells therapies The market landscape is fragmented, featuring a mix of companies of all sizes; however, small and mid-sized companies represent 70% of the overall number of industry stakeholders. It is worth highlighting that over 50% of the CMOs claim to be capable of accommodating both clinical and commercial scales of operation.

100+ strategic alliances have been inked since 2015 In fact, nearly 60% of the abovementioned deals were established post 2016. Majority of these agreements were observed to be focused on the manufacturing of various types of stem cells. It is worth highlighting that the maximum number of partnerships related to stem cell therapies were reported in 2018.

More than 80,000+ patients were reported to have been enrolled in stem cell therapy related trials, since 2010 As a result, the manufacturing demand for such therapies can be anticipated to grow significantly over the next decade. The report features detailed projections of the future clinical and commercial demand for stem cell manufacturing, based on parameters, such as target patient population, dosing frequency, dose strength, source of stem cells, type of stem cells and key geographies.

Currently, there are more than 100 facilities dedicated to stem cell manufacturing The maximum share of the installed capacity belongs to large (more than 1,000 employees) and very large (more than 5,000 employees) companies. The report provides a detailed capacity analysis, taking into consideration the reported manufacturing capacities of industry stakeholders, and offering estimates on the distribution of the global contract manufacturing capacity for stem cell therapies, by company size, scale of operation and geography.

By 2030, North America and Europe are anticipated to capture over 70% of the market share Overall, the market is anticipated to witness an annualized growth rate of more than 20% over the next decade. In the long-term, the opportunity is expected to be well distributed across key stakeholder companies, which offer services for a diverse range of allogenic and autologous stem cell therapies.

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The USD 2.5 billion (by 2030) financial opportunity within the stem cells contract manufacturing market has been analyzed across the following segments:

The report features inputs from eminent industry stakeholders, according to whom the contract manufacturing opportunity related to stem cell therapies can be expected to witness substantial growth due to the rising demand for regenerative medicine across a number of therapeutic areas. The report includes detailed transcripts of discussions held with the following experts:

The research covers detailed profiles of key players (illustrative list provided below) from across key global markets (North America, Europe and Asia-Pacific); each profile provides an overview of the company, information on its service portfolio, manufacturing facilities, financial performance (if available), details on recent developments, as well as an informed future outlook.

For additional details, please visit https://www.rootsanalysis.com/reports/view_document/stem-cell-therapy-contract-manufacturing-market-2019-2030/271.html

or email [emailprotected]

Contact: Gaurav Chaudhary +1 (415) 800 3415 +44 (122) 391 1091 [emailprotected]

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Contract Manufacturing Services Market for stem cells is expected to be worth over USD 2.5 billion by 2030, claims Roots Analysis - KYT24

November 2020: Intramural Papers of the Month – Environmental Factor Newsletter

Intramural Papers

Intramural By Nicholas Alagna, Mimi Huang, Sanya Mehta, Prashant Rai, and Saniya Rattan

Assessing the potential carcinogenicity and toxicity of botanical dietary supplements, such as Ginkgo biloba extract (GbE), in rodent systems is challenging due to the variability in commercially available products. To address this issue, scientists at the NIEHS Divisions of the National Toxicology Program (NTP) and Intramural Research used several analytical chemistry and chemometric techniques to compare the composition of GbE used in recent NTP research with other GbE samples on the market, as well as with the National Institute of Standards and Technology (NIST) GbE standard reference materials. Their results suggested that a simple analysis for the presence, absence, or amount of compounds unique to GbE would be adequate to determine the authenticity of a GbE sample.

The scientists conducted chemometric analysis of chromatographic and spectrophotometric data to determine that GbE used in rodent experiments was most similar to the NIST reference materials and two unfinished products, as well as finished commercial products containing an authentic GbE extract, based on their constituent profiles. Because the team found its particular GbE was representative of other high quality GbE products, the results of the NTP carcinogenicity and toxicity study could be more broadly applied to other similar GbE products on the market. (NA)

Citation:Collins BJ, Kerns SP, Aillon K, Mueller G, Rider CV, DeRose EF, London RE, Harnly JM, Waidyanatha S. 2020. Comparison of phytochemical composition of Ginkgo biloba extracts using a combination of non-targeted and targeted analytical approaches. Anal Bioanal Chem 412(25):67896809.

Researchers from NIEHS and its Division of NTP found that subtle changes to mitochondrial function led to long-lasting epigenomic effects in the mouse. Scientists identified that mitochondrial inhibition during early development persistently altered DNA methylation and liver gene expression throughout the life of the mouse. The long-term effects observed in this study shed light on potential mechanisms involved with health outcomes under the developmental origins of health and disease paradigm.

To assess the effects of subtle alteration of mitochondrial function on epigenetics, researchers used the viable yellow agouti mouse, Avy, which reveals DNA methylation changes through changes in the coat color of the animals. Mice born from mothers fed with a mitochondrial inhibitor, rotenone, solely during gestation and lactation, showed an altered coat color distribution. The mice also showed altered DNA methylation and gene expression patterns in the liver, effects that were observed up to 18 months after rotenone exposure had ceased. Finally, the animals showed that prenatal rotenone exposure led to altered mitochondrial and antioxidant function later in life, demonstrating that early exposure influenced long-term health outcomes.

This study places mitochondria as players in controlling gene expression through epigenetic mechanisms and highlights how environmental toxicants could influence long-term health outcomes. (SR)

Citation:Lozoya OA, Xu F, Grenet D, Wang T, Grimm SA, Godfrey V, Waidyanatha S, Woychik RP, Santos JH. 2020. Single nucleotide resolution analysis reveals pervasive, long-lasting DNA methylation changes by developmental exposure to a mitochondrial toxicant. Cell Rep 32(11):108131.

To uncover novel deletion patterns in mitochondrial DNA (mtDNA), NIEHS researchers and their collaborators developed LostArc, an ultrasensitive method for quantifying deletions in circular mtDNA molecules. The team used the technique to reveal links between mitochondrial DNA replication, aging, and mitochondrial disease.

A mutation in POLG, a nuclear gene responsible for maintaining the mitochondrial genome, is known to be the most common cause of mitochondrial disease, a condition where the mitochondria fail to produce enough energy for the body to function properly.

The scientists analyzed mtDNA from skeletal muscle biopsies of 41 patients with mitochondrial disease with wild-type (WT) and mutated POLG. They used LostArc to detect loss of mtDNA segments by mapping split-reads in the samples to a normal mtDNA reference. Thirty-five million deletion segments were detected in the biopsies. They spanned more than 470,000 unique segments, 99% of which were novel. The scientists also found that ablation, or loss of mtDNA segments to deletion, significantly increased with age. Mutated POLG samples had higher ablation levels than WT. These changes in mtDNA ablation help explain some of the muscular symptoms of aging and disease. The additional potential applications of LostArc include genetic screening, diagnostic applications, and medical forensics. (SM)

Citation:Lujan SA, Longley MJ, Humble MH, Lavender CA, Burkholder A, Blakely EL, Alston CL, Gorman GS, Turnbull DM, McFarland R, Taylor RW, Kunkel TA, Copeland WC. 2020. Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging. Genome Biol 21(1):248.

The cellular signaling molecule InsP7 can modify the abundance of cytosolic, membrane-less condensates called P-bodies through a new epitranscriptomic process identified by NIEHS researchers and their collaborators. P-bodies contain structurally and metabolically stabilized mRNAs, which can subsequently be released to drive protein expression in response to environmental stress. The mRNA release can sometimes promote protein expression in a specific location within the cell and can also direct stem cell differentiation. The possible role of P-bodies in aging and neurodegenerative disease suggests potential therapeutic implications of these findings.

The relationship between InsP7 and P-bodies is centered on the enzyme NUDT3, a phosphate-cleaving enzyme that not only metabolizes InsP7 but also removes the structurally stabilizing cap from the mRNA. By competing with NUDT3-catalyzed mRNA cap removal, InsP7 increases mRNA transcript levels and P-body abundance. It appears that de-capping enzymes like NUDT3 each have specific mRNA targets, so this regulatory ability of InsP7 is likely specific to NUDT3. Thus, the authors study is a significant step forward in the understanding of how the cell can selectively regulate the fate and function of specific mRNA transcripts. (MH)

Citation:Sahu S, Wang Z, Jiao X, Gu C, Jork N, Wittwer C, Li X, Hostachy S, Fiedler D, Wang H, Jessen HJ, Kiledjian M, Shears SB. 2020. InsP7 is a small-molecule regulator of NUDT3-mediated nRNA decapping and processing-body dynamics. Proc Natl Acad Sci U S A 117(32):1924519253.

NIEHS scientists and their collaborators reported that spatial protein-DNA interaction between transcription factors and their specific binding sites in the genome is a key step to initiating the transcription of genetic code. The study was conducted on a transcription factor called GATA3, which can bind directly to the condensed structural units of the human genome, called nucleosomes, and drive transcription of genes necessary for cellular reprogramming and differentiation.

The study used high-resolution mapping to reveal that GATA3 binding near the central axis of the nucleosome coil was associated with remodeling of local DNA structure to facilitate a productive reading of genetic code. This binding was found to be independent of the genetic sequence of nucleosomes. The study used an in vitro model of a nucleosome and cryoelectron microscopy and found that nonproductive GATA3 binding, without any structural changes to the nucleosome, occurred efficiently at the periphery of the nucleosome coil.

Binding of a transcription factor, such as GATA3, in a specific spatial arrangement on the nucleosome surface affects the local genomic scaffolds and could determine the overall outcome of such binding in gene regulation. (PR)

Citation:Tanaka H, Takizawa Y, Takaku M, Kato D, Kumagawa Y, Grimm SA, Wade PA, Kurumizaka H. 2020. Interaction of the pioneer transcription factor GATA3 with nucleosomes. Nat Commun 11(1):4136. (Story)

(Nicholas Alagna is an Intramural Research Training Award [IRTA] fellow in the NIEHS Mechanisms of Mutation Group. Mimi Huang, Ph.D., is an IRTA fellow in the Division of the National Toxicology Program Systems Toxicology Group. Sanya Mehta is an IRTA postbaccalaureate fellow in the NIEHS Matrix Biology Group. Prashant Rai, Ph.D., is a visiting fellow in the NIEHS Clinical Investigation of Host Defense Group. Saniya Rattan, Ph.D., is an IRTA fellow in the NIEHS Reproductive Developmental Biology Group.)

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November 2020: Intramural Papers of the Month - Environmental Factor Newsletter

Cell Banking Outsourcing Market: High Demand for Stem Cell Therapies to Trigger Growth of the Market – BioSpace

Global Cell Banking Outsourcing Market: Overview

The global cell banking outsourcing market is likely to be driven by the rising demand for biopharmaceutical production targeting novel active sites, stem cell therapy, and gene therapy. A cell bank is a facility storing cells extracted from various organ tissue and body fluids so as to cater to the needs of the future. The cell banks make storage of cells with an elaborate characterization of the entire cell line as it reduces the possibilities of cross contamination. These benefits are estimated to fuel expansion of the global cell banking outsourcing market over the timeframe of assessment, from 2020 to 2030.

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Cell banking outsourcing industries engage testing, characterization, storage, and collection of tissues, cell lines, and the cells. These activities are done to assist in the production of biopharmaceuticals and in the research and development activities so as to ensure minimum adverse effects and high effectiveness. The procedure of the cell storage involves first proliferation of cells, which then multiplies in a huge number of identical cells and is then put inside cryovials safety for use in future. Cells are primarily utilized in the production of regenerative medicine. A surge in the number of cell banks together with the high demand for stem cell therapies is likely to work in favor of the global cell banking outsourcing market over the tenure of analysis, from 2020 to2030.

The global cell banking outsourcing market has been segmented on the basis of four important parameters, which are bank type, phase, cell type, and region.

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Global Cell Banking Outsourcing Market: Notable Developments

The global cell banking outsourcing market is considered a fairly competitive market and is marked with the presence of many leading market players. The companies in this market are forging mergers, partnerships, and collaborations so as to gain larger revenue and market share. The following development is expected to play an important role in the market:

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Global Cell Banking Outsourcing Market: Key Trends

The global cell banking outsourcing market is characterized by the presence of the following restraints, drivers, and opportunities.

High Demand for Stem Cell Therapies to Trigger Growth of the Market

The rising number of stem cell therapies across the globe primarily influences the global cell banking outsourcing market. According to a survey conducted by World Network for Blood and Marrow Transplantation (WBMN), nearly 1 million hematopoietic stem cell transplantation processes were conducted in between 2006 to 2014. These figure comprised removal of stem cells procedures from peripheral blood or bone marrow, proliferating, and then finally storing them cell banks for future use by patients. Stem cell therapies are able to multiple disease, such as amyotrophic lateral sclerosis, type 1 diabetes, cancer, Alzheimer's disease, Parkinson's disease, and so on. Ability to cure such a wide variety of diseases is expected to propel growth of the global cell banking outsourcing market in the years to come.

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Global Cell Banking Outsourcing Market: Geographical Analysis

North America is expected to dominate the global cell banking outsourcing market throughout the timeframe of analysis, from 2020 to 2030. Such high growth of the North America market is ascribed to the increased production of antibiotics, therapeutics protein, and vaccines. In addition, presence of several biopharmaceutical companies in the region is anticipated to foster growth of the cell banking outsourcing market in North America in the near future.

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Cell Banking Outsourcing Market: High Demand for Stem Cell Therapies to Trigger Growth of the Market - BioSpace

Autologous Stem Cell Based Therapies Market to Witness Increase in Revenues by 2020-2026 – PRnews Leader

Beathan Report has released the International report on The Autologous Stem Cell Based Therapies market, which is made up of advice about each of the essential parameters of this market like ingestion and the manufacturing patterns coupled with all the earnings patterns for the prediction period. Concerning creation aspect, the report provides complete detailed analysis about the manufacturing procedures combined with the gross financials accumulated by the very best most producers working within this business. The main facet of this Autologous Stem Cell Based Therapies market thats covered in the report helps the customers and the associations to better comprehend the company profile concerning drivers, restraints, challenges, and opportunities affecting and pertaining the market dynamics.

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Key market players

Major competitors identified in this market include Regeneus, Mesoblast, Pluristem Therapeutics Inc, US STEM CELL, INC., Brainstorm Cell Therapeutics, Tigenix, Med cell Europe, etc.

Based on the Region:

Asia-Pacific (China, Japan, South Korea, India and ASEAN)

North America (US and Canada)

Europe (Germany, France, UK and Italy)

Rest of World (Latin America, Middle East & Africa)

COVID-19 has affected the Overall worldwide companies and itll have a enormous time for the company recovery. Vast majority of the business sectors have realigned their company plans, priorities, and have amended their economic planning so as to stay in the company and keep their standing on the international platform. The thorough evaluation of this Autologous Stem Cell Based Therapies market will enable the brand new market entrants to acquire reliable market approaches and strategy powerful action plans for the prediction period.

Based on the Type:

Embryonic Stem Cell

Resident Cardiac Stem Cells

Umbilical Cord Blood Stem Cells

Based on the Application:

Neurodegenerative Disorders

Autoimmune Diseases

Cardiovascular Diseases

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Important highlights of this Autologous Stem Cell Based Therapies market report:

* COVID-19 effect on the earnings Streams of the Autologous Stem Cell Based Therapies market players.

* Statistics of the overall sales quantity And general market earnings.

* Business trends breakdowns.

* Estimated expansion rate of this Autologous Stem Cell Based Therapies Market.

* In-depth Information Regarding the important Distributors, traders, and dealers.

Key Benefits of the report:

-This report provides an extensive analysis of the current and emerging market trends and dynamics in the global Autologous Stem Cell Based Therapies market.

-In-depth analysis is conducted by constructing market estimations for the key market segments between 2020 and 2027.

-This report entails the detailed quantitative analysis of the current market and estimations through 2020-2027, which assists in identifying the prevailing market opportunities.

-Extensive analysis of the market is conducted by following key product positioning and monitoring the top competitors within the market framework

-Comprehensive analysis of all regions is provided that determines the prevailing opportunities in these geographies.

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Autologous Stem Cell Based Therapies Market to Witness Increase in Revenues by 2020-2026 - PRnews Leader

Checking Science On The Ballot – Science Friday

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Choosing the next U.S. president is not the only decision voters will make in the upcoming 2020 elections. Major science policies are also on the ballot. In some states, people will be casting votes on propositions that influence scientific research and the environment. While in other local elections, candidates with scientific backgrounds are in the running for public office. Jeffrey Mervis of Science Magazine talks about California stem cell research policies and Nevada renewable energy propositions, and how a science platform could help or harm candidates.

Invest in quality science journalism by making a donation to Science Friday.

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Jeffrey Mervis

Jeff Mervis is a senior correspondent for Science magazine and longtime reporter on science policy. Hes based in Washington, D.C.

Alexa Lim

Alexa Lim is a producer for Science Friday. Her favorite stories involve space, sound, and strange animal discoveries.

Ira Flatow

Ira Flatow is the host and executive producer of Science Friday.Hisgreen thumb has revived many an office plant at deaths door.

19 West 44th Street, Suite 412

New York, NY 10036

Science Friday is produced by the Science Friday Initiative, a 501(c)(3) nonprofit organization. Created by Bluecadet

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Checking Science On The Ballot - Science Friday

Stem Cell Manufacturing Market Size, Global Analytical Overview, Key Players, Regional Demand, Trends and Forecast To 2026 – Aerospace Journal

A recent market research report added to repository of Credible Markets is an in-depth analysis of Global Stem Cell Manufacturing Market. On the basis of historic growth analysis and current scenario of Stem Cell Manufacturing market place, the report intends to offer actionable insights on global market growth projections. Authenticated data presented in report is based on findings of extensive primary and secondary research. Insights drawn from data serve as excellent tools that facilitate deeper understanding of multiple aspects of global Stem Cell Manufacturing market.

This report examines all the key factors influencing growth of global Stem Cell Manufacturing market, including demand-supply scenario, pricing structure, profit margins, production and value chain analysis. Regional assessment of global Stem Cell Manufacturing market unlocks a plethora of untapped opportunities in regional and domestic market places. Detailed company profiling enables users to evaluate company shares analysis, emerging product lines, scope of NPD in new markets, pricing strategies, innovation possibilities and much more.

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Key Companies Thermo Fisher Scientific (US) Merck Group (Germany) Becton, Dickinson and Company (US) Bio-Rad Laboratories (US) Miltenyi Biotec (Germany) Takara Bio Group (Japan) STEMCELL Technologies (Canada) Pharmicell (South Korea) Osiris Therapeutics (US) Anterogen (South Korea) Cellular Dynamics International (US) MEDIPOST (South Korea) Lonza Group (Switzerland) Holostem Terapie Avanzate (Italy) Pluristem Therapeutics (Israel) Market by Type HSCs MSCs iPSCs ESCs Instruments Media Consumables Market by Application Research Target Identification Therapy (Autologous, Allogeneic) Cell Banks

By Region

Asia-Pacific[China, Southeast Asia, India, Japan, Korea, Western Asia]

Europe[Germany, UK, France, Italy, Russia, Spain, Netherlands, Turkey, Switzerland]

North America[United States, Canada, Mexico]

Middle East & Africa[GCC, North Africa, South Africa]

South America[Brazil, Argentina, Columbia, Chile, Peru]

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Some Points from Table of Content

Global Stem Cell Manufacturing Market Status (2015-2019) and Forecast (2020-2025) by Region, Product Type & End-Use

Chapter 1 Market Overview

Chapter 2 Key Companies

Chapter 3 Global Market Status and Future Forecast

Chapter 4 Asia-Pacific Market Status and Future Forecast

Chapter 5 Europe Market Status and Future Forecast

Chapter 6 North America Market Status and Future Forecast

Chapter 7 South America Market Status and Future Forecast

Chapter 8 Middle East & Africa Market Status and Future Forecast

Chapter 9 Market Features

9.1 Product Features

9.2 Price Features

9.3 Channel Features

9.4 Purchasing Features

Chapter 10 Investment Opportunity

10.1 Regional Investment Opportunity

10.2 Industry Investment Opportunity

Chapter 11 Coronavirus Impact

11.1 Impact on Industry Upstream

11.2 Impact on Industry Downstream

11.3 Impact on Industry Channels

11.4 Impact on Industry Competition

11.5 Impact on Industry Obtain Employment

Chapter 12 Conclusion

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Points Covered in the Report

The points that are discussed within the report are the major market players that are involved in the market such as market players, raw material suppliers, equipment suppliers, end users, traders, distributors and etc.

The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. This report analysed 12 years data history and forecast.

The growth factors of the market are discussed in detail wherein the different end users of the market are explained in detail.

Data and information by market player, by region, by type, by application and etc., and custom research can be added according to specific requirements.

The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.

Impact of Covid-19 in Stem Cell Manufacturing Market:Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost every country around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Stem Cell Manufacturing market in 2020. The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor/outdoor events restricted; over forty countries state of emergency declared; massive slowing of the supply chain; stock market volatility; falling business confidence, growing panic among the population, and uncertainty about future.

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Thanks for reading this article you can also get individual chapter wise section or region wise report version like North America, Europe, MEA or Asia Pacific.

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Stem Cell Manufacturing Market Size, Global Analytical Overview, Key Players, Regional Demand, Trends and Forecast To 2026 - Aerospace Journal